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下島 恭弘  シモジマ ヤスヒロ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 内科学第三FAX番号
職名准教授メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

プロフィール

研究分野
膠原病学
臨床免疫学
学歴
取得学位
博士(医学) , 信州大学大学院

研究活動業績

研究業績(著書・
発表論文等)
論文
Circulating regulatory T cells in adult-onset Still's disease: Focusing on their plasticity and stability
CLINICAL AND EXPERIMENTAL IMMUNOLOGY,206(2):184-195 2021(Nov.)
Author:Shimojima, Yasuhiro; Ichikawa, Takanori; Kishida, Dai; Takamatsu, Ryota; Sekijima, Yoshiki;
Keywords:adult-onset Still's disease; effector cytokines; helper T cell-related cytokines; plasticity; regulatory T cells;


The implication of interferon-gamma-producing immunocompetent cells for evaluating disease activity and severity in adult-onset Still's disease
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES,24(9):1176-1185 2021(Sep.)
Author:Ichikawa, Takanori; Shimojima, Yasuhiro; Kishida, Dai; Ueno, Ken-ichi; Sekijima, Yoshiki;
Keywords:adult-onset Still's disease; CD4+cells; interferon-gamma; interleukin-12; interleukin-18; NK cells;


Oxidative Stress Promotes Instability of Regulatory T Cells in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
FRONTIERS IN IMMUNOLOGY,12:789740 2021
Author:Shimojima, Yasuhiro; Kishida, Dai; Ichikawa, Takanori; Takamatsu, Ryota; Nomura, Shun; Sekijima, Yoshiki;
Keywords:regulatory T cells; reactive oxygen species; FoxP3; ANCA-associated vasculitis; effector cytokines; plasticity; mTOR; resveratrol;


Cerebrospinal fluid levels of BAFF and APRIL as direct indicators of disease activity in anti-neutrophil cytoplasmic antibody-related hypertrophic pachymeningitis
CLINICAL RHEUMATOLOGY,39(10):3145-3148 2020(Oct.)
Author:Shimojima, Yasuhiro; Kishida, Dai; Nomura, Shun; Sekijima, Yoshiki;


Clinical characteristics of patients with myalgia as the initial manifestation of small and medium-sized vasculitis: a retrospective study
RHEUMATOLOGY INTERNATIONAL,40(10):1667-1674 2020(Oct.)
Author:Ushiyama, Satoru; Shimojima, Yasuhiro; Ueno, Ken-ichi; Kishida, Dai; Miyazaki, Daigo; Sekijima, Yoshiki;
Keywords:Myalgia; ANCA-associated vasculitis; Polyarteritis nodosa; Microscopic polyangiitis;


Cerebrospinal fluid biomarkers implicated in the pathogenesis of anti-neutrophil cytoplasmic antibody-related hypertrophic pachymeningitis
CLINICAL RHEUMATOLOGY,39(6):1803-1811 2020(Jun.)
Author:Ikeda, Junji; Shimojima, Yasuhiro; Usami, Yoko; Ueno, Ken-ichi; Kishida, Dai; Sekijima, Yoshiki;


Clinical characteristics in patients with myalgia as the initial manifestation of small and medium-sized vasculitis: a retrospective study.
Rheumatol Int,40:1667-1674 2020
Author:Ushiyama S, Shimojima Y, Ueno KI, Kishida D, Miyazaki D, Sekijima Y.


Characteristics of Circulating Natural Killer Cells and Their Interferon-gamma Production in Active Adult-onset Still Disease
JOURNAL OF RHEUMATOLOGY,46(10):1268-1276 2019
Author:Shimojima, Yasuhiro; Kishida, Dai; Ueno, Ken-ichi; Ushiyama, Satoru; Ichikawa, Takanori; Sekijima, Yoshiki;


Imbalanced expression of dysfunctional regulatory T cells and T-helper cells relates to immunopathogenesis in polyarteritis nodosa
MODERN RHEUMATOLOGY,27(1):102-109 2017
Author:Shimojima, Yasuhiro; Ishii, Wataru; Kishida, Dai; Fukushima, Kazuhiro; Ikeda, Shu-ichi;


T-cell receptor-mediated characteristic signaling pathway of peripheral blood T cells in dermatomyositis and polymyositis
AUTOIMMUNITY,50(8):481-490 2017
Author:Shimojima, Yasuhiro; Matsuda, Masayuki; Ishii, Wataru; Kishida, Dai; Sekijima, Yoshiki;


Effective Use of Calcineurin Inhibitor in Combination Therapy for Interstitial Lung Disease in Patients With Dermatomyositis and Polymyositis
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY,23(2):87-93 2017
Author:Shimojima, Yasuhiro; Ishii, Wataru; Matsuda, Masayuki; Kishida, Dai; Ikeda, Shu-ichi;


Hypertrophic pachymeningitis is a characteristic manifestation of granulomatosis with polyangiitis: A retrospective study of anti-neutrophil cytoplasmic antibody-associated vasculitis
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES,20(4):489-496 2017
Author:Shimojima, Yasuhiro; Kishida, Dai; Hineno, Akiyo; Yazaki, Masahide; Sekijima, Yoshiki; Ikeda, Shu-ichi;


Increased BAFF and APRIL levels in the cerebrospinal fluid of patients with anti-neutrophilcytoplasmic antibody-related hypertrophic pachymeningitis
CYTOKINE,99:305-309 2017
Author:Shimojima, Yasuhiro; Kishida, Dai; Sekijima, Yoshiki;


NADPH oxidase deficiency underlies dysfunction of aged CD8(+) Tregs
JOURNAL OF CLINICAL INVESTIGATION,126(5):1953-1967 2016(May)
Author:Wen, Zhenke; Shimojima, Yasuhiro; Shirai, Tsuyoshi; Li, Yinyin; Ju, Jihang; Yang, Zhen; Tian, Lu; Goronzy, Jorg J.; Weyand, Cornelia M.;


Advantage of administering tacrolimus for improving prognosis of patients with polymyositis and dermatomyositis
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES,19(12):1322-1330 2016
Author:Ueno, Ken-ichi; Shimojima, Yasuhiro; Kishida, Dai; Sekijima, Yoshiki; Ikeda, Shu-ichi;


Regulatory T Cells and the Immune Aging Process: A Mini-Review
GERONTOLOGY,60(2):130-137 2014
Author:Jagger, Ann; Shimojima, Yasuhiro; Goronzy, Jorg J.; Weyand, Cornelia M.;