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松田 和之  マツダ カズユキ

教員組織学術研究院(保健学系)電話番号0263-37-2365
教育組織医学部 保健学科 生体情報検査学FAX番号0263-37-2370
職名教授メールアドレスkmatsuda@shinshu-u.ac.jp
住所〒390-8621 松本市旭 3-1-1ホームページURL

プロフィール

研究分野
病態検査学
病態医科学
現在の研究課題
共培養系を用いた線維化機構の解析
キーワード:線維化
若年性骨髄単球性白血病由来iPS細胞を用いた病態解析
キーワード:若年性骨髄単球性白血病 , iPS細胞
所属学会
所属学会
日本人類遺伝学会
日本臨床衛生検査技師会
日本臨床検査医学会

所属学会役職担当
2019- , 日本人類遺伝学会 , 教育推進委員会 委員
2017- , 日本人類遺伝学会 , 臨床細胞遺伝学認定士制度認定施設(信州大学医学部・医学部附属病院)責任指導士
2014- , 長野県臨床検査技師会  , 遺伝子研究班 班長
2016-2019 , 日本臨床検査医学会 , 遺伝子委員会 委員
2008-2011 , 長野県臨床検査技師会  , 遺伝子研究班 副班長
2006-2010 , 日本染色体遺伝子検査学会 , 理事
2002-2005 , 長野県臨床検査技師会 , 中信支部 幹事
学歴
出身大学院
2007 , 信州大学大学院 , 医学研究科
2001 , 東京医科歯科大学大学院 , 医学研究科保健衛生学専攻

出身学校・専攻等(大学院を除く)
1999 , 東京医科歯科大学 , 医学部 , 保健衛生学科・検査技術学専攻

取得学位
医学博士 , 信州大学
保健学修士 , 東京医科歯科大学

免許・資格等
2017 , 日本食品安全協会 健康食品管理士
2010 , 日本人類遺伝学会 臨床細胞遺伝学 指導士
2003 , 日本人類遺伝学会 臨床細胞遺伝学認定士
1999 , 臨床検査技師免許
受賞学術賞
2017 , 第52回小島三郎記念技術賞
2013 , 日本臨床検査医学会 学会賞(検査・技術賞)
2012 , 信州大学医学部病態解析診断学講座・同附属病院臨床検査部同門会賞
2011 , 公益信託日本白血病研究基金 一般研究賞
2011 , 小児血液・がん学会 学術賞
2007 , 信州大学医学部松医会 奨励賞
2006 , 日本臨床検査医学会 学会賞(奨励賞)
2002 , 長野県臨床検査学会 学術賞
研究職歴等
研究職歴以外の職歴
2018- , 信州大学医学部保健学科 教授
2012-2018 , 信州大学医学部附属病院臨床検査部 副臨床検査技師長
2006-2012 , 信州大学医学部附属病院臨床検査部 主任臨床検査技師
2001-2006 , 信州大学医学部附属病院臨床検査部 臨床検査技師

研究活動業績

研究業績(著書・
発表論文等)
書籍等出版物
最新 臨床検査学講座 遺伝子・染色体検査学第2版 第2章 染色体の基礎、第4章 染色体検査の基礎、第6章 染色体検査の実践
医歯薬出版株式会社 2021(Feb. 10)
Author:松田和之


「臨床検査技師のための研究入門」:2章「研究の進めかた」研究と論文の種類, 検査と技術 増刊号 48 9, 862-868
医学書院 2020(Sep. 15)
Author:松田和之


「臨床検査技師のための研究入門」:4章「知っておくべき研究TIPS」医学研究者(Biomedical Laboratory Scientist)を目指すには, 検査と技術 増刊号 48 9, 946-950
医学書院 2020(Sep. 15)
Author:松田和之


2020年版 臨床検査ポケット資料集 「遺伝子・染色体検査」
ポケット資料集作製委員会 2020
Author:松田和之


スタンダード検査血液学 第4版 6.蛍光 in situ ハイブリダイゼーション(FISH)法 , 151-152
医歯薬出版株式会社 東京 2020
Author:松田和之


遺伝子・染色体検査技術教本 (JAMT技術教本シリーズ) 第6章 先天異常 6.1 染色体異常症候群, 日本臨床衛生検査技師会 監修: 遺伝子・染色体検査技術教本 (JAMT技術教本シリーズ)
丸善出版(東京) 2019(May 31)
Author:松田和之


異常値の出るメカニズム 第7版 第16章 遺伝学的検査
医学書院(東京) 2018(Mar. 31)
Author:松田和之


Methods in Molecular Biology vol 1310: Molecular Typing of Blood Cell Antigens 「High-speed droplet-allele specific-polymerase chain reaction for genotyping of single nucleotide polymorphisms」
Springer 2015
Author:Matsuda K


臨床検査法提要改訂第34版 第4章 「臨床血液検査 III. 造血器腫瘍の臨床検査 C. 染色体検査」、第10章 「輸血・移植関連検査, IV. キメリズム検査」、第12章 「染色体検査・遺伝子関連検査 II. 染色体検査 5. 核型記載 b. 腫瘍細胞の染色体核型記載法」
金原出版(東京) 2014(Jun.)
Author:松田和之


若葉マーク 臨床検査学エッセンス・ノート 4 臨床病因・生体防御検査 chapter 4 「遺伝子・染色体検査」
メジカルビュー社(東京) 2013(Nov.)
Author:松田和之


検査診断学への展望-臨床検査指針:測定とデータ判読のポイント- 「白血病における移植後キメリズム検査-遺伝子・染色体検査からのアプローチ-」
南江堂(東京) 2013(Jun.)
Author:松田和之


「最新 染色法のすべて」「VII. 染色体検査」
医歯薬出版(東京) 2011(Mar.)
Author:松田和之


遺伝子検査技術-遺伝子分析科学認定士テキスト 「1. 応用編 5. 染色体検査の実践 A. 細胞培養法」
宇宙堂八木書店(東京) 2007(Mar.)
Author:松田和之


論文
Mutated GM-CSF-based CAR-T cells targeting CD116/CD131 complexes exhibit enhanced anti-tumor effects against acute myeloid leukaemia
Clin Transl Immunology.,10(5):e1282 2021(May 06)
Author:Hasegawa A, Saito S, Narimatsu S, Nakano S, Nagai M, Ohnota H, Inada Y, Morokawa H, Nakashima I, Morita D, Ide Y, Matsuda K, Tashiro H, Yagyu S, Tanaka M, Nakazawa Y.


Colitis-associated colorectal adenocarcinomas frequently express claudin 18 isoform 2: Implications for claudin 18.2 monoclonal antibody therapy
Histopathology 2021(Feb. 16)
Author:Iwaya M, Hayashi H, Nakajima T, Matsuda K, Kinugawa Y, Tobe Y, Tateishi Y, Iwaya Y, Uehara T, Ota H


Relationship between allergic sensitisation-associated single-nucleotide polymorphisms and allergic transfusion reactions and febrile non-haemolytic transfusion reactions in paediatric cases
Blood Transfus 2021(Feb. 03)
Author:Ide Y, Yanagisawa R, Kobayashi J, Komori K, Matsuda K, Amano Y, Nakazawa Y, Takeshita T, Sakashita K, Tozuka M.


Direct Delivery of piggyBac CD19 CAR T Cells Has Potent Anti-tumor Activity against ALL Cells in CNS in a Xenograft Mouse Model.
Mol Ther Oncolytics 2020(May 26)
Author:Tanaka K, Kato I, Tanaka M, Morita D, Matsuda K, Takahashi Y, Nakahata T, Umeda K, Hiramatsu H, Adachi S, Takita J, Nakazawa Y.


Osteopontin enhances the migration of lung fibroblasts via upregulation of interleukin-6 through the ERK pathway
Biological chemistry 2020(Apr. 28)
Author:Yu Fujisawa, Kazuyuki Matsuda, Takeshi Uehara


Complete measurable residual disease response after combination chemotherapy with AML-type and ALL-type regimens in pediatric B/myeloid acute bilineal leukemia
LEUKEMIA & LYMPHOMA,61(4):967-970 2020
Author:Saito, Shoji; Taira, Chiaki; Matsuda, Kazuyuki; Yanagisawa, Ryu; Morita, Daisuke; Shigemura, Tomonari; Yoshikawa, Kentaro; Tanaka, Miyuki; Sakashita, Kazuo; Mukai, Saki; Shimodaira, Shigetaka; Koike, Kenichi; Nakazawa, Yozo;


NLRP3 upregulation in A549 cells co-cultured with THP-1 macrophages under hypoxia via deregulated TGF-beta signaling
EXPERIMENTAL CELL RESEARCH,383(1):111506 2019(Oct. 01)
Author:Furukawa, Satomi; Matsuda, Kazuyuki; Sugano, Mitsutoshi; Uehara, Takeshi; Honda, Takayuki;


Essential role of PTPN11 mutation in enhanced haematopoietic differentiation potential of induced pluripotent stem cells of juvenile myelomonocytic leukaemia
BRITISH JOURNAL OF HAEMATOLOGY,187(2):163-173 2019(Oct.)
Author:Shigemura, Tomonari; Matsuda, Kazuyuki; Kurata, Takashi; Sakashita, Kazuo; Okuno, Yusuke; Muramatsu, Hideki; Yue, Fengming; Ebihara, Yasuhiro; Tsuji, Kohichiro; Sasaki, Katsunori; Nakahata, Tatsutoshi; Nakazawa, Yozo; Koike, Kenichi;


Significance of Molecular Monitoring of T Cells for the Decision of Treatment Strategy for Epstein-Barr Virus-associated Hemophagocytic Lymphohistiocytosis
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY,41(5):407-409 2019(Jul.)
Author:Saito, Takamasa; Tanaka, Miyuki; Matsuda, Kazuyuki; Honma, Hitoshi; Komori, Kazutoshi; Morita, Daisuke; Nakazawa, Hideyuki; Yanagisawa, Ryu; Nakazawa, Yozo;


Factors predicting the recurrence of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children after treatment using the HLH-2004 protocol
Int J Hematol,109(5):612-617 2019(May)
Author:Ryu, Yanagaisawa; Kazuyuki, Matsuda; Shouichi, Ohga; Hirokazu, Kanegane; Akira, Morimoto; Yasuhiro, Okamoto; Akira, Ohara; Keitaro, Fukushima; Manabu, Sotomatsu; Keiko, Nomura; Akiko M, Saito; Keizo, Horibe; Eiichi, Ishii; Yozo, Nakazawa


FGA1238bp欠失を有する無フィブリノゲン血症3例のハプロタイプ解析
医学検査,68(3):589-595 2019(Mar.)
Author:平千明, 竹澤由夏, 新井慎平, 松田和之, 上條途夢, 樋口由美子, 奥村伸生


Outcomes in children with hemophagocytic lymphohistiocytosis treated using HLH-2004 protocol in Japan
INTERNATIONAL JOURNAL OF HEMATOLOGY,109(2):206-213 2019(Feb.)
Author:Yanagisawa, Ryu; Nakazawa, Yozo; Matsuda, Kazuyuki; Yasumi, Takahiro; Kanegane, Hirokazu; Ohga, Shouichi; Morimoto, Akira; Hashii, Yoshiko; Imaizumi, Masue; Okamoto, Yasuhiro; Saito, Akiko M.; Horibe, Keizo; Ishii, Eiichi; HLH LCH Comm; Japan Children's Canc Grp;


Panobinostat inhibits the proliferation of CD34(+)CD38(-)cells under stimulation of hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia
PEDIATRIC BLOOD & CANCER,65(11):ARTN e27261 2018(Nov.)
Author:Kurata, Takashi; Matsuda, Kazuyuki; Hirabayashi, Koichi; Shigemura, Tomonari; Sakashita, Kazuo; Nakahata, Tatsutoshi; Koike, Kenichi;


Upregulation of osteopontin expression via the interaction of macrophages and fibroblasts under IL-1b stimulation
CYTOKINE,110:63-69 2018(Oct.)
Author:Shimodaira, Takahiro; Matsuda, Kazuyuki; Uchibori, Takaaki; Sugano, Mitsutoshi; Uehara, Takeshi; Honda, Takayuki;


Rapid point-of-care testing for epidermal growth factor receptor gene mutations in patients with lung cancer using cell-free DNA from cytology specimen supernatants
INTERNATIONAL JOURNAL OF ONCOLOGY,52(6):2110-2118 2018(Jun.)
Author:Asaka, Shiho; Yoshizawa, Akihiko; Saito, Kazusa; Kobayashi, Yukihiro; Yamamoto, Hiroshi; Negishi, Tatsuya; Nakata, Rie; Matsuda, Kazuyuki; Yamaguchi, Akemi; Honda, Takayuki;


Myelodysplastic syndrome in an infant with constitutional pure duplication 1q41-qter
Hum Genome Var.,5(6) 2018(May 21)
Author:Morokawa, Hirokazu; Kamiya, Motoko; Wakui, Keiko; Kobayashi, Mikiko; Kurata, Takashi; Matsuda, Kazuyuki; Kawamura, Rie; Kanno, Hiroyuki; Fukushima, Yoshimitsu; Nakazawa, Yozo; Kosho, Tomoki


Promoter hypomethylation of SKI in autoimmune pancreatitis
PATHOLOGY RESEARCH AND PRACTICE,214(4):492-497 2018(Apr.)
Author:Kinugawa, Yasuhiro; Uehara, Takeshi; Matsuda, Kazuyuki; Kobayashi, Yukihiro; Nakajima, Tomoyuki; Hamano, Hideaki; Kawa, Shigeyuki; Higuchi, Kayoko; Hosaka, Noriko; Shiozawa, Satoshi; Ishigame, Hiroki; Nakamura, Toshitsugu; Maruyama, Yasuhiro; Nakazawa, Koh; Nakaguro, Masato; Sano, Kenji; Ota, Hiroyoshi;


Enhanced Expression of Anti-CD19 Chimeric Antigen Receptor in piggyBac Transposon-Engineered T Cells
Mol Ther Methods Clin Dev,8:131-140 2018(Mar. 16)
Author:Daisuke, Morita; Nobuhiro, Nishio; Shoji, Saito; Miyuki,Tanaka: Nozomu, Kawashima; Yusuke, Okuno; Satoshi, Suzuki; Kazuyuki, Matsuda; Yasuhiro, Maeda; Matthew H, Wilson; Gianpietro, Dotti; Cliona M, Rooney; Yoshiyuki, Takahashi; Yozo, Nakazawa


Utility of bronchial lavage fluids for epithelial growth factor receptor mutation assay in lung cancer patients: Comparison between cell pellets, cell blocks and matching tissue specimens.
Oncol Lett,15(2):1469-1474 2018(Feb. 15)
Author:Asaka, Sshiho; Yoshizawa, Akihiko; Nakata, Rie; Negishi, Tatsuya; Yamamoto, Hiroshi; Shiina, Takayuki; Shigeto, Shohei; Matsuda, Kazuyuki; Kobayashi, Yukihiro; Honda, Takayuki


Rapid ABO genotyping by high-speed droplet allele-specific PCR using crude samples
JOURNAL OF CLINICAL LABORATORY ANALYSIS,32(1) 2018(Jan.)
Author:Taira, Chiaki; Matsuda, Kazuyuki; Takeichi, Naoya; Furukawa, Satomi; Sugano, Mitsutoshi; Uehara, Takeshi; Okumura, Nobuo; Honda, Takayuki;


Frequent STAT3 Mutations in CD8(+) T Cells from Patients with Pure Red Cell Aplasia
BLOOD,132 2018
Author:Kawakami, Toru; Sekiguchi, Nodoka; Kobayashi, Jun; Imi, Tatsuya; Matsuda, Kazuyuki; Yamane, Taku; Nishina, Sayaka; Senoo, Yasushi; Sakai, Hitoshi; Ito, Toshiro; Koizumi, Tomonobu; Hirokawa, Makoto; Nakao, Shinji; Nakazawa, Hideyuki; Ishida, Fumihiro;


Acute Myeloid Leukemia in a Patient With X-linked Severe Combined Immunodeficiency
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY,39(8):E470-E472 2017(Nov.)
Author:Shigemura, Tomonari; Motobayashi, Mitsuo; Matsuda, Kazuyuki; Shimodaira, Takahiro; Kurata, Takashi; Kobayashi, Norimoto; Agematsu, Kazunaga; Nakazawa, Yozo;


A Novel Mutation in the Fibrinogen B Chain (c.490G > A; End of Exon 3) Causes a Splicing Abnormality and Ultimately Leads to Congenital Hypofibrinogenemia
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(11) 2017(Nov.)
Author:Taira, Chiaki; Matsuda, Kazuyuki; Arai, Shinpei; Sugano, Mitsutoshi; Uehara, Takeshi; Okumura, Nobuo;


Myelomonocytic differentiation associated with NPM1-RARA rearrangement
BRITISH JOURNAL OF HAEMATOLOGY,179(2):183-183 2017(Oct.)
Author:Yanagisawa, Ryu; Ogiso, Yoshifumi; Yoshikawa, Kentaro; Tanaka, Miyuki; Matsuda, Kazuyuki; Ishii, Eizaburo;


Efficacy and safety of anagrelide in childhood essential thrombocythemia
PEDIATRICS INTERNATIONAL,59(9):1017-1018 2017(Sep.)
Author:Kanai, Ayako; Morokawa, Hirokazu; Matsuda, Kazuyuki; Shimazaki, Ei; Nakazawa, Yozo;


A novel, rapid point-of-care test for lung cancer patients to detect epidermal growth factor receptor gene mutations by using real-time droplet-PCR and fresh liquid cytology specimens
ONCOLOGY REPORTS,37(2):1020-1026 2017(Feb.)
Author:Asaka, Shiho; Yoshizawa, Akihiko; Matsuda, Kazuyuki; Yamaguchi, Akemi; Yamamoto, Hiroshi; Shiina, Takayuki; Nakata, Rie; Ogawa, Kaoru; Zhang, Meng; Honda, Takayuki;


IL-6 trans-signaling is another pathway to upregulate Osteopontin
CYTOKINE,90:88-95 2017(Feb.)
Author:Uchibori, Takaaki; Matsuda, Kazuyuki; Shimodaira, Takahiro; Sugano, Mitsutoshi; Uehara, Takeshi; Honda, Takayuki;


A screening method with lymphocyte percentage and proportion of granular lymphocytes in the peripheral blood for large granular lymphocyte (LGL) leukemia
INTERNATIONAL JOURNAL OF HEMATOLOGY,105(1):87-91 2017(Jan.)
Author:Tanahashi, Takahiro; Sekiguchi, Nodoka; Matsuda, Kazuyuki; Matsumoto, Akihiro; Ito, Toshiro; Nakazawa, Hideyuki; Ishida, Fumihiro;


多項目自動血球分析装置XE2100(シスメックス)のDIFFスキャタグラムにおける側方蛍光低値から発見された異常ヘモグロビン症の4例
医学検査,66(2):96-102 2017
Author:中越 りつこ;向井 早紀;松田 和之;竹澤 由夏;新井 慎平;菅野 光俊;本田 孝行;奥村 伸生
Keywords:多項目自動血球分析装置XE2100;DIFFスキャタグラム;異常ヘモグロビン;HbJ-Calabria;Hb-Yamagata


PCR-Based Detection Methods for Single-Nucleotide Polymorphism or Mutation: Real-Time PCR and Its Substantial Contribution Toward Technological Refinement
ADVANCES IN CLINICAL CHEMISTRY, VOL 80,80:45-72 2017
Author:Matsuda, Kazuyuki;


Methylation of Tumor Suppressor Genes in Autoimmune Pancreatitis
PANCREAS,46(5):614-618 2017
Author:Kinugawa, Yasuhiro; Uehara, Takeshi; Sano, Kenji; Matsuda, Kazuyuki; Maruyama, Yasuhiro; Kobayashi, Yukihiro; Nakajima, Tomoyuki; Hamano, Hideaki; Kawa, Shigeyuki; Higuchi, Kayoko; Hosaka, Noriko; Shiozawa, Satoshi; Ishigame, Hiroki; Ota, Hiroyoshi;


Diagnosis and treatment of juvenile myelomonocytic leukemia
PEDIATRICS INTERNATIONAL,58(8):681-690 2016(Aug.)
Author:Sakashita, Kazuo; Matsuda, Kazuyuki; Koike, Kenichi;


Cell size variations of large granular lymphocyte leukemia: Implication of a small cell subtype of granular lymphocyte leukemia with STAT3 mutations
LEUKEMIA RESEARCH,45:8-13 2016(Jun.)
Author:Tanahashi, Takahiro; Sekiguchi, Nodoka; Matsuda, Kazuyuki; Takezawa, Yuka; Ito, Toshiro; Kobayashi, Hikaru; Ichikawa, Naoaki; Nishina, Sayaka; Senoo, Noriko; Sakai, Hitoshi; Nakazawa, Hideyuki; Ishida, Fumihiro;


Loss of Mismatched HLA on the Leukemic Blasts of Patients With Relapsed Lymphoid Malignancies Following Bone Marrow Transplantation From Related Donors With HLA Class II Mismatches in the Graft Versus Host Direction
PEDIATRIC BLOOD & CANCER,63(4):709-711 2016(Apr.)
Author:Hirabayashi, Koichi; Kurata, Takashi; Horiuchi, Kazuki; Saito, Shoji; Shigemura, Tomonari; Tanaka, Miyuki; Yanagisawa, Ryu; Matsuda, Kazuyuki; Sakashita, Kazuo; Koike, Kenichi; Nakazawa, Yozo;


Early detection of Rhizopus DNA in the serum of a patient with rhino-orbital-cerebral mucormycosis following allogeneic hematopoietic stem cell transplantation
INTERNATIONAL JOURNAL OF HEMATOLOGY,103(3):354-355 2016(Mar.)
Author:Shigemura, Tomonari; Nishina, Sayaka; Nakazawa, Hideyuki; Matsuda, Kazuyuki; Yaguchi, Takashi; Nakazawa, Yozo;


Evaluation of saliva as diagnostic materials for influenza virus infection by PCR-based assays
CLINICA CHIMICA ACTA,453:71-74 2016
Author:Sueki, Akane; Matsuda, Kazuyuki; Yamaguchi, Akemi; Uehara, Masayuki; Sugano, Mitsutoshi; Uehara, Takeshi; Honda, Takayuki;


Rapid diagnosis of acute promyelocytic leukemia with the PML-RARA fusion gene using a combination of droplet-reverse transcription-polymerase chain reaction and instant-quality fluorescence in situ hybridization
CLINICA CHIMICA ACTA,453:38-41 2016
Author:Shigeto, Shohei; Matsuda, Kazuyuki; Yamaguchi, Akemi; Sueki, Akane; Uehara, Masayuki; Sugano, Mitsutoshi; Uehara, Takeshi; Honda, Takayuki;


A novel automated device for rapid nucleic acid extraction utilizing a zigzag motion of magnetic silica beads
ANALYTICA CHIMICA ACTA,906:1-6 2016
Author:Yamaguchi, Akemi; Matsuda, Kazuyuki; Uehara, Masayuki; Honda, Takayuki; Saito, Yasunori;


Anti-proliferative effects of T cells expressing a ligand-based chimeric antigen receptor against CD116 on CD34(+) cells of juvenile myelomonocytic leukemia
JOURNAL OF HEMATOLOGY & ONCOLOGY,9 2016
Author:Nakazawa, Yozo; Matsuda, Kazuyuki; Kurata, Takashi; Sueki, Akane; Tanaka, Miyuki; Sakashita, Kazuo; Imai, Chihaya; Wilson, Matthew H.; Koike, Kenichi;


High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia
BLOOD,128(20):2465-2468 2016
Author:Andersson, Emma I.; Tanahashi, Takahiro; Sekiguchi, Nodoka; Gasparini, Vanessa Rebecca; Bortoluzzi, Sabrina; Kawakami, Toru; Matsuda, Kazuyuki; Mitsui, Takeki; Eldfors, Samuli; Bortoluzzi, Stefania; Coppe, Alessandro; Binatti, Andrea; Lagstrom, Sonja; Ellonen, Pekka; Fukushima, Noriyasu; Nishina, Sayaka; Senoo, Noriko; Sakai, Hitoshi; Nakazawa, Hideyuki; Kwong, Yok-Lam; Loughran, Thomas P.; Maciejewski, Jaroslaw P.; Mustjoki, Satu; Ishida, Fumihiro;


Analysis of KRAS and NRAS Gene Mutations in Arab Asian Children With Acute Leukemia: High Frequency of RAS Mutations in Acute Lymphoblastic Leukemia
PEDIATRIC BLOOD & CANCER,62(12):2157-2161 2015(Dec.)
Author:Al-Kzayer, Lika'a Fasih Y.; Sakashita, Kazuo; Al-Jadiry, Mazin Faisal; Al-Hadad, Salma Abbas; Ghali, Hasanein Habeeb; Uyen, Le T. N.; Liu, Tingting; Matsuda, Kazuyuki; Abdulkadhim, Jaafar M. H.; Al-Shujairi, Tariq Abadi; Matti, Zead Ismael I. K.; Sughayer, Maher A.; Rihani, Rawad; Madanat, Faris F.; Inoshita, Toshi; Kamata, Minoru; Koike, Kenichi;


EBV核酸増幅検査用第一次国際標準品(1st WHO International Standard)に基づく二次標準物質を用いた末梢血中Epstein-Barr virus(EBV)DNA量の評価
医学検査,64(1):48-53 2015
Author:岩下 千奈美;末木 茜;松田 和之;井出 裕一郎;菅野 光俊;石田 文宏;本田 孝行
Keywords:EBウイルス;リアルタイムPCR;第一次国際標準品;移植後リンパ球増殖性疾患;EBV関連血球貪食性リンパ組織球症


Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) as a Useful Immunohistochemical Marker for the Diagnosis of Adenocarcinoma of Small Intestine
ACTA HISTOCHEMICA ET CYTOCHEMICA,48(6):193-204 2015
Author:Daikuhara, Seiichi; Uehara, Takeshi; Higuchi, Kayoko; Hosaka, Noriko; Iwaya, Mai; Maruyama, Yasuhiro; Matsuda, Kazuyuki; Arakura, Norikazu; Tanaka, Eiji; Ota, Hiroyoshi;


Rapid single nucleotide polymorphism based method for hematopoietic chimerism analysis and monitoring using high-speed droplet allele-specific PCR and allele-specific quantitative PCR
CLINICA CHIMICA ACTA,445:101-106 2015
Author:Taira, Chiaki; Matsuda, Kazuyuki; Yamaguchi, Akemi; Uehara, Masayuki; Sugano, Mitsutoshi; Okumura, Nobuo; Honda, Takayuki;


Development of a rapid and sensitive one-step reverse transcription-nested polymerase chain reaction in a single tube using the droplet-polymerase chain reaction machine
CLINICA CHIMICA ACTA,448:150-154 2015
Author:Yamaguchi, Akemi; Matsuda, Kazuyuki; Sueki, Akane; Taira, Chiaki; Uehara, Masayuki; Saito, Yasunori; Honda, Takayuki;


FISH法により末梢血中にドナーリンパ球を同定した脳死肝移植後溶血性貧血の1例
移植,50(4):429-433 2015
Author:山本 悠太;中澤 勇一;小林 聡;池上 俊彦;宮川 眞一;増田 雄一;井出 裕一郎;松田 和之;小嶋 俊介;石川 伸介;大野 康成;三田 篤義;浦田 浩一
Keywords:hemolytic anemia;deceased donor liver transplantation;passenger lymphocytes;fluorescence in situ hybridization


Evaluation of Mucorales DNA load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin B
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,29:200-202 2014(Dec.)
Author:Shigemura, Tomonari; Nakazawa, Yozo; Matsuda, Kazuyuki; Motobayashi, Mitsuo; Saito, Shoji; Koike, Kenichi;


Frequent Coexistence of RAS Mutations in RUNX1-Mutated Acute Myeloid Leukemia in Arab Asian Children
PEDIATRIC BLOOD & CANCER,61(11):1980-1985 2014(Nov.)
Author:Al-Kzayer, Lika'a Fasih Y.; Sakashita, Kazuo; Al-Jadiry, Mazin Faisal; Al-Hadad, Salma Abbas; Uyen, Le T. N.; Liu, Tingting; Matsuda, Kazuyuki; Abdulkadhim, Jaafar M. H.; Al-Shujairi, Tariq Abadi; Matti, Zead Ismael I. K.; Hasan, Janan Ghalib; Al-Abdullah, Hussam M. Salih; Inoshita, Toshi; Kamata, Minoru; Sughayer, Maher A.; Madanat, Faris F.; Koike, Kenichi;


Anti-leukemic potency of piggyBac-mediated CD 19-specific T cells against refractory Philadelphia chromosome-positive acute lymphoblastic leukemia
CYTOTHERAPY,16(9):1257-1269 2014(Sep.)
Author:Saito, Shoji; Nakazawa, Yozo; Sueki, Akane; Matsuda, Kazuyuki; Tanaka, Miyuki; Yanagisawa, Ryu; Maeda, Yasuhiro; Sato, Yuko; Okabe, Seiichi; Inukai, Takeshi; Sugita, Kanji; Wilson, Matthew H.; Rooney, Cliona M.; Koike, Kenichi;


Serial monitoring of Mucorales DNA load in serum samples of a patient with disseminated mucormycosis after allogeneic bone marrow transplantation
INTERNATIONAL JOURNAL OF HEMATOLOGY,100(2):206-209 2014(Aug.)
Author:Shigemura, Tomonari; Nakazawa, Yozo; Matsuda, Kazuyuki; Sano, Kenji; Yaguchi, Takashi; Motobayashi, Mitsuo; Saito, Shoji; Noda, Shunsuke; Kobayashi, Norimoto; Agematsu, Kazunaga; Honda, Takayuki; Koike, Kenichi;


N-homocysteinylation of apolipoprotein A-I impairs the protein's antioxidant ability but not its cholesterol efflux capacity
BIOLOGICAL CHEMISTRY,395(6):641-648 2014(Jun.)
Author:Miyazaki, Akari; Sagae, Nozomi; Usami, Yoko; Sato, Megumi; Kameda, Takahiro; Yoshimoto, Akira; Ishimine, Nau; Matsuda, Kazuyuki; Sugano, Mitsutoshi; Hara, Masayuki; Honda, Takayuki; Tozuka, Minoru;


Analysis of class I and II aberrations in Iraqi childhood acute myeloid leukemia using filter paper cards
ANNALS OF HEMATOLOGY,93(6):949-955 2014(Jun.)
Author:Al-Kzayer, Lika'a Fasih Y.; Uyen, Le Thanh N.; Al-Jadiry, Mazin Faisal; Al-Hadad, Salma Abbas; Al-Badri, Safaa A. Faraj; Ghali, Hasanein Habeeb; Ameen, Najiha Ahmed; Liu, Tingting; Matsuda, Kazuyuki; Abdulkadhim, Jaafar M. H.; Al-Shujairi, Tariq Abadi; Matti, Zead Ismael I. K.; Hasan, Janan Ghalib; Al-Abdullah, Hussam M. Salih; Al-Ani, Mouroge H.; Saber, Paiman Ali I.; Khalil, Hisham Maree; Inoshita, Toshi; Kamata, Minoru; Koike, Kenichi; Sakashita, Kazuo;


変異特異的PCR法による微小残存病変評価
臨床病理,62(6):552-559 2014(Jun.)
Author:松田和之


STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia
CANCER SCIENCE,105(3):342-346 2014(Mar.)
Author:Ishida, Fumihiro; Matsuda, Kazuyuki; Sekiguchi, Nodoka; Makishima, Hideki; Taira, Chiaki; Momose, Kayoko; Nishina, Sayaka; Senoo, Noriko; Sakai, Hitoshi; Ito, Toshiro; Kwong, Yok-Lam;


A New High-Speed Droplet-Real-Time Polymerase Chain Reaction Method Can Detect Bovine Respiratory Syncytial Virus in Less than 10 Min
JOURNAL OF VETERINARY MEDICAL SCIENCE,76(3):477-480 2014(Mar.)
Author:Uehara, Masayuki; Matsuda, Kazuyuki; Sugano, Mitsutoshi; Honda, Takayuki;


リンパ腫細胞における過剰マーカー染色体の形成機序-胸水ギムザ染色標本からの形態学的推測-
日本検査血液学会雑誌,15(1):71-77 2014(Feb.)
Author:徳竹孝好, 野崎美智江, 松田和之, 中田昭平, 北谷陽平, 馬場ひさみ, 武田 航, 清水郁夫


Cytokine production profiles in chronic relapsing-remitting experimental autoimmune encephalomyelitis: IFN-gamma and TNF-alpha are important participants in the first attack but not in the relapse
JOURNAL OF THE NEUROLOGICAL SCIENCES,340(1-2):117-122 2014
Author:Hidaka, Yoshihiko; Inaba, Yuji; Matsuda, Kazuyuki; Itoh, Makoto; Kaneyama, Tomoki; Nakazawa, Yozo; Koh, Chang-Sung; Ichikawa, Motoki;


Epithelial-mesenchymal transition of A549 cells is enhanced by co-cultured with THP-1 macrophages under hypoxic conditions
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,453(4):804-809 2014
Author:Sueki, Akane; Matsuda, Kazuyuki; Iwashita, Chinami; Taira, Chiaki; Ishimine, Nau; Shigeto, Shohei; Kawasaki, Kenji; Sugano, Mitsutoshi; Yamamoto, Hiroshi; Honda, Takayuki;


STAT5b Gene Mutations and Their Association with a Unique Immunophenotype of CD4+CD56+TCR alpha beta Type LGL Leukemia
BLOOD,124(21) 2014
Author:Tanahashi, Takahiro; Matsuda, Kazuyuki; Sekiguchi, Nodoka; Nishina, Sayaka; Senoo, Noriko; Sakai, Kaoko; Sakai, Hitoshi; Ito, Toshiro; Mitsui, Takeki; Kwong, Yok Lam; Ishida, Fumihiro;


若年性骨髄単球性白血病の分子病態と治療の進歩
臨床血液,54(6):538-544 2013(Jun. 30)
Author:小池 健一;松田 和之
Keywords:JMML;RAS mutation;CBL mutation;Hematologic improvement


siRNA down-regulation of FGA mRNA in HepG2 cells demonstrated that heterozygous abnormality of the A alpha-chain gene does not affect the plasma fibrinogen level
THROMBOSIS RESEARCH,131(4):342-348 2013(Apr.)
Author:Takezawa, Yuka; Matsuda, Kazuyuki; Terasawa, Fumiko; Sugano, Mitsutoshi; Honda, Takayuki; Okumura, Nobuo;


Identification of sites in apolipoprotein A-I susceptible to chymase and carboxypeptidase A digestion
BIOSCIENCE REPORTS,33:49-56 2013
Author:Usami, Yoko; Kobayashi, Yukihiro; Kameda, Takahiro; Miyazaki, Akari; Matsuda, Kazuyuki; Sugano, Mitsutoshi; Kawasaki, Kenji; Kurihara, Yuriko; Kasama, Takeshi; Tozuka, Minoru;


Rapid detection of PML-RARA fusion gene by novel high-speed droplet-reverse transcriptase-polymerase chain reaction: Possibility for molecular diagnosis without lagging behind the morphological analyses
CLINICA CHIMICA ACTA,415:276-278 2013
Author:Sueki, Akane; Matsuda, Kazuyuki; Taira, Chiaki; Yamaguchi, Akemi; Koeda, Hiroshi; Takagi, Fumio; Kobayashi, Yukihiro; Sugano, Mitsutoshi; Honda, Takayuki;


Novel high-speed droplet-allele specific-polymerase chain reaction: Application in the rapid genotyping of single nucleotide polymorphisms
CLINICA CHIMICA ACTA,424:39-46 2013
Author:Taira, Chiaki; Matsuda, Kazuyuki; Yamaguchi, Akemi; Sueki, Akane; Koeda, Hiroshi; Takagi, Fumio; Kobayashi, Yukihiro; Sugano, Mitsutoshi; Honda, Takayuki;


Spliceosome-related gene mutations in myelodysplastic syndrome can be used as stable markers for monitoring minimal residual disease during follow-up
LEUKEMIA RESEARCH,36(11):1393-1397 2012(Nov.)
Author:Matsuda, Kazuyuki; Ishida, Fumihiro; Ito, Toshiro; Nakazawa, Hideyuki; Miura, Shuhei; Taira, Chiaki; Sueki, Akane; Kobayashi, Yukihiro; Honda, Takayuki;


Genetic evaluation of childhood acute lymphoblastic leukemia in Iraq using FTA cards
PEDIATRIC BLOOD & CANCER,59(3):461-467 2012(Sep.)
Author:Al-Kzayer, Lika'a Fasih Y.; Sakashita, Kazuo; Matsuda, Kazuyuki; Al-Hadad, Salma Abbas; Al-Jadiry, Mazin Faisal; Abed, Wisam Majeed; Abdulkadhim, Jaafar M. H.; Al-Shujairi, Tariq Abadi; Hasan, Janan Ghalib; Al-Abdullah, Hussam M. Salih; Al-Ani, Mouroge H.; Saber, Paiman Ali I.; Inoshita, Toshi; Kamata, Minoru; Koike, Kenichi;


Molecular analysis of afibrinogenemic mutations caused by a homozygous FGA1238 bp deletion, and a compound heterozygous FGA1238 bp deletion and novel FGA c.54+3A > C substitution
INTERNATIONAL JOURNAL OF HEMATOLOGY,96(1):39-46 2012(Jul.)
Author:Takezawa, Yuka; Terasawa, Fumiko; Matsuda, Kazuyuki; Sugano, Mitsutoshi; Tanaka, Aiko; Fujiwara, Mitsuhiro; Kainuma, Keigo; Okumura, Nobuo;


マルチプレックスPCR法およびGeneScan法を用いたEBウィルス関連血液貪食症候群におけるT細胞受容体遺伝子再構成の解析
臨床化学,41(3):259-264 2012(Jul.)
Author:松田和之, 菅野光俊, 本田孝行


Long-term haematological improvement after non-intensive or no chemotherapy in juvenile myelomonocytic leukaemia and poor correlation with adult myelodysplasia spliceosome-related mutations
BRITISH JOURNAL OF HAEMATOLOGY,157(5):647-650 2012(Jun.)
Author:Matsuda, Kazuyuki; Yoshida, Nao; Miura, Shuhei; Nakazawa, Yozo; Sakashita, Kazuo; Hyakuna, Nobuyuki; Saito, Masahiro; Kato, Fumiyo; Ogawa, Atsushi; Watanabe, Akihiro; Sotomatsu, Manabu; Kobayashi, Chie; Ito, Toshiro; Ishida, Fumihiro; Manabe, Atsushi; Kojima, Seiji; Koike, Kenichi;


ミスマッチPCR法を用いたSNPs解析による母体血中の胎児DNA検出の検討
臨床病理,60(1):19-26 2012(Jan. 25)
Author:小林 美和;松田 和之;寺澤 文子;奥村 伸生;本田 孝行;吉川 文彦;根津 八紘
Keywords:一塩基多型;胎児 DNA;ミスマッチプライマー;ジーンスキャン解析;リアルタイムPCR


子宮内胎児死亡の原因検索に頬粘膜細胞による間期核FISH法が有用であった1症例
臨床病理,60(1):32-36 2012(Jan. 25)
Author:竹澤 由夏;古庄 知己;松田 和之;平 千明;伊藤 友里花;日高 惠以子;菅野 光俊;鳴海 洋子;水内 麻子;小原 久典;涌井 敬子;奥村 伸生;福嶋 義光;本田 孝行
Keywords:螢光 in situ ハイブリダイゼーション;頬粘膜細胞;子宮内胎児死亡;トリプロイディー症候群


A Case of Mikulicz's Disease Complicated by Malignant Lymphoma: A Postmortem Histopathological Finding
INTERNAL MEDICINE,51(4):419-423 2012
Author:Uehara, Takeshi; Ikeda, Shu-ichi; Hamano, Hideaki; Kawa, Shigeyuki; Moteki, Hideaki; Matsuda, Kazuyuki; Kaneko, Yasunori; Hara, Eiji;


PCR for monitoring of minimal residual disease in hematologic malignancy
CLINICA CHIMICA ACTA,413(1-2):74-80 2012
Author:Matsuda, Kazuyuki; Sugano, Mitsutoshi; Honda, Takayuki;


Application of allele-specific quantitative PCR using genomic DNA to monitor minimal residual disease based on mutant gene levels following allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies: Comparison of mutant levels with autologous DNA percentage by short tandem repeat-PCR
CLINICA CHIMICA ACTA,413(3-4):516-519 2012
Author:Taira, Chiaki; Matsuda, Kazuyuki; Saito, Shoji; Sakashita, Kazuo; Sugano, Mitsutoshi; Okumura, Nobuo; Honda, Takayuki;


Determination of Myeloperoxidase-Induced apoAI-apoAII Heterodimers in High-Density Lipoprotein
ANNALS OF CLINICAL AND LABORATORY SCIENCE,42(4):384-391 2012
Author:Kameda, Takahiro; Usami, Yoko; Shimada, Saki; Haraguchi, Go; Matsuda, Kazuyuki; Sugano, Mitsutoshi; Kurihara, Yuriko; Isobe, Mitsuaki; Tozuka, Minoru;


A novel high-speed droplet-polymerase chain reaction can detect human influenza virus in less than 30 min
CLINICA CHIMICA ACTA,413(21-22):1742-1745 2012
Author:Matsuda, Kazuyuki; Yamaguchi, Akemi; Taira, Chiaki; Sueki, Akane; Koeda, Hiroshi; Takagi, Fumio; Sugano, Mitsutoshi; Honda, Takayuki;


Genetic analysis of TP53 in childhood myelodysplastic syndrome and juvenile myelomonocytic leukemia
LEUKEMIA RESEARCH,35(12):1578-1584 2011(Dec.)
Author:Saito, Shoji; Matsuda, Kazuyuki; Taira, Chiaki; Sano, Kenji; Tanaka-Yanagisawa, Miyuki; Yanagisawa, Ryu; Nakazawa, Yozo; Sakashita, Kazuo; Shiohara, Masaaki; Koike, Kenichi;


A case of Behcet's disease associated with myelodysplastic syndrome involving trisomy 8 and a gain-of-function mutation in SHP-2
RHEUMATOLOGY,50(7):1342-1344 2011(Jul.)
Author:Shigemura, Tomonari; Agematsu, Kazunaga; Yamazaki, Takashi; Sakashita, Kazuo; Nakayama, Yoshiko; Higuchi, Yumiko; Matsuda, Kazuyuki; Koike, Kenichi;


Disappearance of Minimal Residual Disease After the Early Withdrawal of Immunosuppressants in a Patient With Juvenile Myelomonocytic Leukemia
PEDIATRIC BLOOD & CANCER,56(3):501-502 2011(Mar.)
Author:Yanagisawa, Ryu; Matsuda, Kazuyuki; Sakashita, Kazuo; Nakazawa, Yozo; Tanaka, Miyuki; Saito, Shoji; Yoshikawa, Kentaro; Kamijo, Takehiko; Shiohara, Masaaki; Koike, Kenichi;


Clinicopathological features of hepatitis C virus disease after living donor liver transplantation: relationship with in situ hybridisation data
PATHOLOGY,43(2):156-160 2011(Feb.)
Author:Masuda, Yuichi; Nakazawa, Yuichi; Matsuda, Kazuyuki; Sano, Kenji; Mita, Atsuyshi; Ohno, Yasunari; Urata, Koichi; Ikegami, Toshihiko; Miwa, Shiro; Miyagawa, Shinichi;


キメリズム解析における multiplex short tandem repeat(STR)-PCR 法の検討と検査材料の評価
臨床病理,59(1):24-30 2011(Jan. 25)
Author:平 千明;松田 和之;竹澤 由夏;伊藤 俊朗;石田 文宏;日高 惠以子;熊谷 俊子;本田 孝行
Keywords:マイクロサテライトPCR;造血幹細胞移植;完全キメラ;混合キメラ


Quantitative monitoring of single nucleotide mutations by allele-specific quantitative PCR can be used for the assessment of minimal residual disease in patients with hematological malignancies throughout their clinical course
CLINICA CHIMICA ACTA,412(1-2):53-58 2011
Author:Taira, Chiaki; Matsuda, Kazuyuki; Kamijyo, Yuka; Sakashita, Kazuo; Ishida, Fumihiro; Kumagai, Toshiko; Yamauchi, Kazuyoshi; Okumura, Nobuo; Honda, Takayuki;


Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation
BLOOD,117(10):2887-2890 2011
Author:Takagi, Masatoshi; Shinoda, Kunihiro; Piao, Jinhua; Mitsuiki, Noriko; Takagi, Mari; Matsuda, Kazuyuki; Muramatsu, Hideki; Doisaki, Sayoko; Nagasawa, Masayuki; Morio, Tomohiro; Kasahara, Yoshihito; Koike, Kenichi; Kojima, Seiji; Takao, Akira; Mizutani, Shuki;


Detection of chymase-digested C-terminally truncated apolipoprotein A-I in normal human serum
JOURNAL OF IMMUNOLOGICAL METHODS,369(1-2):51-58 2011
Author:Usami, Yoko; Matsuda, Kazuyuki; Sugano, Mitsutoshi; Ishimine, Nau; Kurihara, Yuriko; Sumida, Tamaki; Yamauchi, Kazuyoshi; Tozuka, Minoru;


Detection of T-cell receptor gene rearrangement in children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis using the BIOMED-2 multiplex polymerase chain reaction combined with GeneScan analysis
CLINICA CHIMICA ACTA,412(17-18):1554-1558 2011
Author:Matsuda, Kazuyuki; Nakazawa, Yozo; Yanagisawa, Ryu; Honda, Takayuki; Ishii, Eiichi; Koike, Kenichi;


Factor H gene variants in Japanese: Its relation to atypical hemolytic uremic syndrome
MOLECULAR IMMUNOLOGY,49(1-2):48-55 2011
Author:Mukai, Saki; Hidaka, Yoshihiko; Hirota-Kawadobora, Masako; Matsuda, Kazuyuki; Fujihara, Noriko; Takezawa, Yuka; Kubota, Seiko; Koike, Kenichi; Honda, Takayuki; Yamauchi, Kazuyoshi;


Induction of High Endothelial Venule-like Vessels Expressing GlcNAc6ST-1-mediated L-selectin Ligand Carbohydrate and Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM-1) in a Mouse Model of "Candidatus Helicobacter heilmannii"-induced Gastritis and Gastric Mucosa-associated Lymphoid Tissue (MALT) Lymphoma
HELICOBACTER,15(6):538-548 2010(Dec.)
Author:Suzuki, Akira; Kobayashi, Motohiro; Matsuda, Kazuyuki; Matsumoto, Takeshi; Kawakubo, Masatomo; Kumazawa, Shigeyuki; Koide, Naohiko; Miyagawa, Shinichi; Ota, Hiroyoshi;


Multicenter evaluation of prototype real-time PCR assays for Epstein-Barr virus and cytomegalovirus DNA in whole blood samples from transplant recipients
MICROBIOLOGY AND IMMUNOLOGY,54(9):516-522 2010(Sep.)
Author:Ito, Yoshinori; Takakura, Shunji; Ichiyama, Satoshi; Ueda, Mitsuharu; Ando, Yukio; Matsuda, Kazuyuki; Hidaka, Eiko; Nakatani, Kaname; Nishioka, Junji; Nobori, Tsutomu; Kajiyama, Naoki; Kimura, Hiroshi;


Identification of N-homocysteinylated apolipoprotein AI in normal human serum
Ann Clin Biochem,47(Pt 5):453-459 2010(Sep.)
Author:Ishimine N, Usami Y, Nogi S, Sumida T, Kurihara Y, Matsuda K, Nakamura K, Yamauchi K, Okumura N, Tozuka M.


SMARCB1 gene with a 27-base pair (bp) deletion is not a mutation
CANCER GENETICS AND CYTOGENETICS,199(1):65-65 2010(May)
Author:Sano, Kenji; Matsuda, Kazuyuki; Yoichi, Kohara;


Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia
BRITISH JOURNAL OF HAEMATOLOGY,148(4):593-599 2010(Feb.)
Author:Matsuda, Kazuyuki; Sakashita, Kazuo; Taira, Chiaki; Tanaka-Yanagisawa, Miyuki; Yanagisawa, Ryu; Shiohara, Masaaki; Kanegane, Hirokazu; Hasegawa, Daiichiro; Kawasaki, Keiichiro; Endo, Mikiya; Yajima, Shuhei; Sasaki, Shinya; Kato, Keisuke; Koike, Kazutoshi; Kikuchi, Akira; Ogawa, Atsushi; Watanabe, Akihiro; Sotomatsu, Manabu; Nonoyama, Shigeaki; Koike, Kenichi;


ホルマリン固定時間, 材料に適したHER-2 FISH法の検討 : 2種類のキットを用いた操作法の簡便性とシグナル検出の比較
臨床病理,58(1):25-29 2010(Jan. 25)
Author:宇原 美帆;松田 和之;下條 康代;日高 惠以子;熊谷 俊子;上原 剛;佐野 健司;本田 孝行
Keywords:ヒト上皮成長因子受容体2;ホルマリン固定パラフィン包埋組織;螢光 in situ ハイブリダイゼーション


Long-term survival after nonintensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of healthy persons with the mutations
BLOOD,115(26):5429-5431 2010
Author:Matsuda, Kazuyuki; Taira, Chiaki; Sakashita, Kazuo; Saito, Shoji; Tanaka-Yanagisawa, Miyuki; Yanagisawa, Ryu; Nakazawa, Yozo; Shiohara, Masaaki; Fukushima, Keitaro; Oda, Megumi; Honda, Takayuki; Nakahata, Tatsutoshi; Koike, Kenichi;


「i-チップ」マイクロチップ電気泳動システムを用いた ESBL Multiplex PCR の解析
生物物理化學,53(3) 2009(Aug. 10)
Author:鈴木 剛史;春日 恵理子;松本 竹久;松田 和之;山内 一由;熊谷 俊子;本田 孝行


異常フィブリノゲンヘテロ接合体γ鎖Arg 275Cys 2家系とγ鎖Arg275His 3家系のフィブリノゲン機能比較とハプロタイプ解析
臨床病理,57(7):651-658 2009(Jul. 25)
Author:上條 由夏;廣田 川戸洞 雅子;藤原 祝子;若林 早紀;松田 和之;山内 一由;寺澤 文子;奥村 伸生;本田 孝行
Keywords:フィブリノゲン異常症;フィブリン重合反応;第XIII因子によるフィブリン架橋反応;一塩基多型;ショートタンデムリピート


若年性骨髄単球性白血病の病態解析と治療の進歩
日本小児血液学会雑誌,23(3):183-191 2009(Jun.)
Author:小池健一, 松田和之


Correlation of Clinical Features With the Mutational Status of GM-CSF Signaling Pathway-Related Genes in Juvenile Myelomonocytic Leukemia
PEDIATRIC RESEARCH,65(3):334-340 2009(Mar.)
Author:Yoshida, Nao; Yagasaki, Hiroshi; Xu, Yinyan; Matsuda, Kazuyuki; Yoshimi, Ayami; Takahashi, Yoshiyuki; Hama, Asahito; Nishio, Nobuhiro; Muramatsu, Hideki; Watanabe, Nobuhiro; Matsumoto, Kimikazu; Kato, Koji; Ueyama, Junichi; Inada, Hiroko; Goto, Hiroaki; Yabe, Miharu; Kudo, Kazuko; Mimaya, Junichi; Kikuchi, Akira; Manabe, Atsushi; Koike, Kenichi; Kojima, Seiji;


Simple polymerase chain reaction for the detection of mutations and deletions in the epidermal growth factor receptor gene: Applications of this method for the diagnosis of non-small-cell lung cancer
Clin Chim Acta,401(1-2):68-72 2009(Mar.)
Author:Uhara, Miho; Matsuda, Kazuyuki; Taira, Chiaki; Higuchi, Yumiko; Okumura, Nobuo; Yamauchi, Kazuyoshi;


Cryptic insertion into 11q23 of MLLT10 not involved in t(1;15;11;10)(p36;q11;q23;q24) in infant acute biphenotypic leukemia
CANCER GENETICS AND CYTOGENETICS,190(2):113-120 2009
Author:Matsuda, Kazuyuki; Tanaka, Miyuki; Araki, Sachiko; Yanagisawa, Ryu; Yamauchi, Kazuyoshi; Koike, Kenichi;


Promising approach for aggressive NK cell leukaemia with allogeneic haematopoietic cell transplantation
EUROPEAN JOURNAL OF HAEMATOLOGY,81(2):107-111 2008(Aug.)
Author:Ito, Toshiro; Makishima, Hideki; Nakazawa, Hideyuki; Kobayashi, Hikaru; Shimodaira, Shigetaka; Nakazawa, Yozo; Kitano, Kiyoshi; Matsuda, Kazuyuki; Hidaka, Eiko; Ishida, Fumihiro;


Recent advances in the pathogenesis and management of juvenile myelomonocytic leukaemia
BRITISH JOURNAL OF HAEMATOLOGY,141(5):567-575 2008(Jun.)
Author:Koike, Kenichi; Matsuda, Kazuyuki;


骨髄移植後のキメリズム解析を不可能にした再発時付加染色体異常
臨床血液 = The Japanese Journal of Clinical Hematology,49(2):109-114 2008(Feb. 29)
Author:樋口 由美子;伊藤 俊朗;松田 和之;樋口 司;日高 惠以子;今川 英里;宇原 美帆;中澤 英之;石田 文宏;山内 一由;佐野 健司;勝山 努
Keywords:Hematopoietic stem cell transplantation;Chimerism;Fluorescence in situ hybridization;FISH;Short tandem repeats;STR


Quantitative analysis of the effect of Helicobacter pylori on the expressions of SOX2, CDX2, MUC2, MUC5AC, MUC6, TFF1, TFF2, and TFF3 mRNAs in human gastric carcinoma cells
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY,43(1):25-33 2008
Author:Matsuda, Kazuyuki; Yamauchi, Kazuyoshi; Matsumoto, Takehisa; Sano, Kenji; Yamaoka, Yoshio; Ota, Hiroyoshi;


De novo autoimmune hepatitis following living-donor liver transplantation for primary biliary cirrhosis
CLINICAL TRANSPLANTATION,22(3):385-390 2008
Author:Yoshizawa, Kaname; Shirakawa, Haruaki; Ichijo, Tetsuya; Umemura, Takeji; Tanaka, Eiji; Kiyosawa, Kendo; Imagawa, Eri; Matsuda, Kazuyuki; Hidaka, Eiko; Sano, Kenji; Nakazawa, Yuichi; Ikegami, Toshihiko; Hashikura, Yasuhiko; Miyagawa, Shinichi; Ota, Masao; Nakano, Masayuki;


FISH法で診断しえた myeloid sarcoma の1例
臨床病理,55(12):1084-1087 2007(Dec.)
Author:今川英里, 松田和之, 日高惠以子, 宇原美帆, 上原 剛, 佐野健司, 山内一由


Acquisition of loss of the wild-type NRAS locus with aggressive disease progression in a patient with juvenile myelomonocytic leukemia and a heterozygous NRAS mutation
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL,92(11):1576-1578 2007(Nov.)
Author:Matsuda, Kazuyuki; Nakazawa, Yozo; Sakashita, Kazuo; Shiohara, Masaaki; Yamauchi, Kazuyoshi; Koike, Kenichi;


Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations
BLOOD,109(12):5477-5480 2007
Author:Matsuda, Kazuyuki; Shimada, Akira; Yoshida, Nao; Ogawa, Atsushi; Watanabe, Akihiro; Yajima, Shuhei; Iizuka, Susumu; Koike, Kazutoshi; Yanai, Fumio; Kawasaki, Keiichiro; Yanagimachi, Masakatsu; Kikuchi, Akira; Ohtsuka, Yoshitoshi; Hidaka, Eiko; Yamauchi, Kazuyoshi; Tanaka, Miyuki; Yanagisawa, Ryu; Nakazawa, Yozo; Shiohara, Masaaki; Manabe, Atsushi; Kojima, Seiji; Koike, Kenichi;


A complex karyotype, including a three-way translocation generating a NUP98-HOXD13 transcript, in an infant with acute myeloid leukemia
CANCER GENETICS AND CYTOGENETICS,176(2):137-143 2007
Author:Hidaka, Eiko; Tanaka, Miyuki; Matsuda, Kazuyuki; Ishikawa-Matsumura, Masayo; Yamauchi, Kazuyoshi; Sano, Kenji; Honda, Takayuki; Wakui, Keiko; Yanagisawa, Ryu; Nakazawa, Yozo; Sakashita, Kazuo; Shiohara, Masaaki; Ishii, Eizaburo; Koike, Kenichi;


A case of acute myelogenous leukemia with MLL-AF10 fusion caused by insertion of 5 ' MLL into 10p12, with concurrent 3 ' MLL deletion
CANCER GENETICS AND CYTOGENETICS,171(1):24-30 2006(Nov.)
Author:Matsuda, Kazuyuki; Hidaka, Eiko; Ishida, Futnihiro; Yamauchi, Kazuyoshi; Makishima, Hideki; Ito, Toshiro; Suzuki, Takefumi; Imagawa, Eri; Sano, Kenji; Katsuyama, Tsutomu; Ota, Hiroyoshi;


Co-localization of TFF2 with gland mucous cell mucin in gastric mucous cells and in extracellular mucous gel adherent to normal and damaged gastric mucosa
Histochem Cell Biol,126(5):617-625 2006(Nov.)
Author:Ota, Hiroyoshi; Hayama, Masayoshi; Momose, Masanobu; El-Zimaity HM, Matsuda, Kazuyuki; Sano, Kenji; Maruta, Fukuto; Okumura, Nobuo; Katsuyama, Tsutomu;


Chromosomal change during 6-mercaptopurine (6-MP) therapy in juvenile myelomonocytic leukemia: the growth of a 6-MP-refractory clone that already exists at onset
Leukemia,20(3):485-490 2006(Mar.)
Author:Matsuda, Kazuyuki; Matsuzaki, Satoshi; Miki, Jun; Hidaka, Eiko; Yanagisawa, Ryu; Nakazawa, Yozo; Sakashita, Kazuo; Kamijo, Takehiko; Asami, Keiko; Sano, Kenji; Koike, Kenichi;


腫瘍性疾患の診断とモニタリングのための有効な遺伝的マーカーの選択
臨床病理 = THE OFFICIAL JOURNAL OF JAPANESE SOCIETY OF LABORATORY MEDICINE,54(2):132-136 2006(Feb. 25)
Author:佐野 健司;松田 和之;鈴木 剛史;今川 英理;日高 惠以子;川久保 雅友;上原 剛
Keywords:遺伝的マーカー;キメラ遺伝子;FISH;マルチプレックスPCR;定量PCR


Regulation of the ASC expression in response to LPS stimulation is related to IL-8 secretion in the human intestinal mucosa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,346(3):968-973 2006
Author:Masumoto, Junya; Kobayashi, Hitoshi; Nakamura, Takamichi; Kaneko, Yasunori; Ota, Hiroyoshi; Hasegawa, Mizuho; Kobayashi, Yukihiro; Suzuki, Takefumi; Matsuda, Kazuyuki; Sano, Kenji; Katsuyama, Tsutomu; Inohara, Naohiro;


間期核 FISH 法における BCR/ABL 融合遺伝子の判定基準の確立
医学検査,54(12):1485-1489 2005(Dec.)
Author:曽根美智子, 清水雅代, 竹本賢一, 佐藤悦子, 大神明子, 藤澤真一, 松田和之, 坂場幸治


Development of two cytogenetically abnormal clones from multipotential hematopoietic stem cells in a patient with juvenile myelomonocytic leukemia
Leukemia Research,29(9):1069-1072 2005(Sep.)
Author:Matsuzaki, Satoshi; Matsuda, Kazuyuki; Miki, Jun; Nakazawa, Yozo; Sakashita, Kazuo; Kamijo, Takehiko; Hidaka, Eiko; Koike, Kenichi;


Monitoring of Hematopoietic Chimerism by Short Tandem Repeats, and the Effect of CD Selection on Its Sensitivity
Clin Chem,50(12):2411-2414 2004(Dec.)
Author:Matsuda, Kazuyuki; Yamauchi, Kazuyohsi; Tozuka, Minoru; Suzuki, Takefumi; Sugano, Mitsutoshi; Hidaka, Eiko; Sano, Kenji; Katsuyama, Tsutomu;


Bilineage acute leukemia of T-lymphoid and myeloid lineages
Haematologica,89(9):1139-1141 2004(Sep.)
Author:Kobayashi, Norimoto; Matsuda, Kazuyuki; Sakashita, Kazuo; Matsuzaki, Satoshi; Iwasaki, Ryu; Koike, Kenichi;


Analysis of an expanded width of albumin fraction by cellulose acetate membrane electrophoresis in IgA nephropathy urine before treatment
J Clin Lab Anal,17(2):37-43 2003(Mar.)
Author:Machii, Ryoko; Matsuda, Kazuyuki; Hiratsuka, Nobuo; Sugimoto, Kayo; Hotta, Osamu; Itoh, Yoshihisa; Yoshida, Hiroshi; Shiba, Kiyoko;


Internalization of beta-amyloid causes downregulation of apolipoprotein E mRNA expression in neuroblastoma cells
Ann Clin Lab Sci,33(1):68-78 2003(Jan.)
Author:Yamauchi, Kazuyoshi; Tozuka, Minoru; Hidaka, Eiko; Ueno, Ichiro; Matsuda, Kazuyuki; Katsuyama, Tsutomu;


Semiquantitative analysis of urinary low protein levels using silver dot blot assay
J Clin Lab Anal,15(4):171-174 2001(Jun.)
Author:Matsuda, Kazuyuki; Hiratsuka, Nobuo; Kurihara, Yuriko; Shiba, Kiyoko;


Sensitive method for detection and semiquantification of Bence Jones protein by cellulose acetate membrane electrophoresis using colloidal silver staining
Clin Chem,47(4):763-766 2001(Apr.)
Author:Matsuda, Kazuyuki; Hiratsuka, Nobuo; Koyama, Takahiro; Kurihara, Yuriko; Hotta, Osamu; Itoh, Yoshihisa; Shiba, K;


MISC
ワンポイントアドバイス:リアルタイムPCRに用いられるクエンチャーの種類と使い分け
検査と技術,50(6):638 2022(Jun. 01)
Author:松田和之


PTPN11遺伝子変異によるJMMLの単球分化異常
血液内科,82(1):30 2021(Jan. 28)
Author:松田和之、中沢洋三


検査レポート作成指南第18回 遺伝子・染色体検査編
臨床検査,61(2):194 2017(Feb.)
Author:松田和之


Topics 身近な話題・世界の話題 (152).ゲノム編集技術を用いたキメラ抗原受容体T細胞療法
血液フロンティア ,26(11):86 2016(Nov.)


はじめて出会う検査画像 第2章 血液学 CMLと言えばフィラデルフィア染色体~歴史的発見から学ぶ異常を見逃さない観察眼
検査と技術,44(10):858 2016(Oct.)


技術講座 シリーズ:造血器腫瘍の診療を支える遺伝子・染色体検査・3:移植後生着確認に利用されるキメリズム検査について
検査と技術,43(9):768 2015(Sep.)


技術講座 シリーズ:造血器腫瘍の診療を支える遺伝子・染色体検査・2 治療効果判定に必要な微小残存病変評価法について
検査と技術,43(8):680 2015(Aug.)
Author:松田和之


技術講座 シリーズ:造血器腫瘍の診療を支える遺伝子・染色体検査・1白血病・リンパ腫の診断に利用される遺伝子・染色体検査法
検査と技術,43(7):594 2015(Jul.)


臨床検査のピットフォール 「移植後生着評価法であるキメリズム検査のピットフォール」
検査と技術,43(3):246 2015(Mar.)
Author:松田和之


臨床医からの質問に答える「これは遺伝子検査?それとも染色体検査?」
検査と技術,43(2):146 2015(Feb.)
Author:松田和之


個別化医療を担う検査―コンパニオン診断 造血器腫瘍治療とコンパニオン診断
臨床検査 ,58(8):908 2014(Aug.)


今日から役立つ遺伝子検査 実践マニュアル「おもな遺伝子関連検査における実際の流れやポイント 5) 悪性リンパ腫における遺伝子・染色体検査」
メディカルテクノロジー,40(13):1603 2012(Dec.)
Author:松田和之


技術講座 遺伝子 染色体検査 fluorescence in situ hybridization (FISH) 法の有用性
検査と技術,37(12):1371 2009(Dec.)
Author:松田和之, 日高惠以子, 本田孝行


特集・小児の血液疾患~新たに明らかになった病態~「4. 若年性骨髄単球性白血病にみられるRAS/MAPK関連遺伝子の変異」
血液フロンティア,18(4):53 2008(Apr.)
Author:松田和之, 小池健一


遺伝子検査-診断とリスクファクター「解析技術 c. 染色体・ゲノムレベル 1) 染色体検査, 遺伝子検査-診断とリスクファクター」
臨床検査,51(12):1319 2007(Nov.)
Author:松田和之

特許等知的財産
登録済特許
遺伝子改変細胞及びその作製方法(米国)
遺伝子改変細胞及びその作製方法(日本)
研究費
共同研究
2020 - 2021 , 高速・簡便な核酸抽出装置の開発
2020 - 2021 , ポータブルPCR装置(myHMPCR)の臨床検査適合性に関する研究
2019 - 2020 , 小型リアルタイムPCRの実用化に向けた要素技術開発

科学研究費補助金(研究代表者)
2021 - 2023 , 若年性骨髄単球性白血病におけるPTPN11遺伝子変異によるメチル化調節機構の解明 , 基盤研究(C)
2018 - 2020 , 「若年性骨髄単球性白血病に対する改変T細胞と分子標的薬による複合治療法の開発」 , 基盤研究(C)
2015 - 2016 , 「患者iPS細胞の遺伝子変異修復と導入による若年性骨髄単球性白血病発症機構の解析」 , 若手研究(B)
2013 - 2014 , 「若年性骨髄単球性白血病患者のiPS細胞を用いた疾患特異的マーカーと治療薬の同定」 , 若手研究(B)
2012 - 2012 , 「糖鎖抗原を標的としたキメラ抗原受容体発現T細胞の構築と抗腫瘍効果の検討」 , 奨励研究
2011 - 2011 , 「GM-CSF受容体に対するキメラ抗原受容体発現T細胞の構築と抗白血病効果の検討」 , 奨励研究
2009 - 2009 , 「末梢血中の微量白血病細胞定量検出に有用なエマルジョンPCR法の確立と臨床応用」 , 奨励研究
2008 - 2008 , 「白血病治療中や移植後の微小残存病変追跡に有用な遺伝子変異特異的PCR法の確立」 , 奨励研究

科学研究費補助金(研究分担者)
2020 - 2022 , 自己免疫性膵炎発症に関与するサイトカインのメチル化異常の解析と病理診断への応用 , 基盤研究(C)
2018 - 2020 , 老化のエピジェネティックメカニズムの解明と運動による予防法の開発 , 基盤研究(B)

奨学寄附金
2019 , アステラス製薬 奨学寄附金 脂肪酸刺激が惹起するインターロイキン 11 およびオステオポンチン産生亢進を介した肝線維化の新たなメカニズム

その他
2019 - , 第34回基礎医学医療研究助成金 ゲノム改変を行った若年性骨髄単球性白血病(JMML)由来 iPS細胞を用いた遺伝子異常とメチル化の細胞増殖への影響の解析
2020 - 2020 , 公益財団法人 中谷医工計測技術振興財団 新型コロナウイルスに対する簡便・迅速な 磁気揺動核酸抽出装置・試薬キットの開発
2019 - 2019 , ノバルティスファーマ 研究助成 喫煙に起因する酸化ストレスによるCOPD発症メカニズムの解明~長期低酸素刺激によるサイトカイン調節機構の異常と線維化との関連性
2018 - 2018 , 平成29年度(第50回)公益財団がん研究振興財団がん研究助成金「遺伝子変異特異的定量PCR法を用いた若年性骨髄単球性白血病に対する分子標的薬効果の検証」
2013 - 2014 , 公益財団法人 東京生化学研究会 研究奨励金 「がん抗原特異的NK細胞活性化キメラ蛋白を用いた次世代がん免疫療法の開発」
2012 - 2012 , 公益信託 永尾武難病研究基金 第14回 研究助成「難治性小児骨髄異形成症候群と骨髄増殖性腫瘍を対象とした疾患特異的iPS細胞の樹立-白血病性幹細胞を標的とする治療薬候補のスクニーニングへの応用」
2011 - 2011 , 公益財団法人 黒住医学研究振興財団 第19回研究助成金「白血病症例における遺伝子変異特異的定量 PCR法を用いた新たな微小残存病変の定量的評価と再発リスクに関する研究」
2010 - 2011 , 公益信託 日本白血病研究基金一般研究賞(学会推薦臨床学研究賞)「遺伝子変異定量解析に基づく若年性骨髄単球性白血病に対する造血幹細胞移植成績の向上」
2010 - 2011 , ホクト生物科学振興財団研究奨励賞「新たな微小残存白血病細胞検査法である遺伝子変異特異的定量 PCR法の確立と臨床応用」
2009 - 2009 , 公益信託臨床検査医学研究振興基金「遺伝子変異特異的定量PCR法を用いた微小残存病変追跡法の臨床応用」
研究諸活動
その他研究活動
2019- , 一般社団法人 日本人類遺伝学会 教育推進委員会 委員
2019- , 学術専門雑誌等編集 , 日本臨床検査学教育協議会 (編集委員)

教育活動実績

授業等
2021 , 前期 , RI検査学
2021 , 前期 , 病態化学検査学
2021 , 前期 , 生化学
2021 , 後期 , 遺伝子検査技術学実習
2020 , 前期 , 生化学
2020 , 前期 , RI 検査学
2020 , 前期 , 病態化学検査学
2020 , 前期 , 臨床検査総論 I
2020 , 後期 , 遺伝子検査技術学実習
2020 , 後期 , 遺伝子検査学
2019 , 前期 , RI検査学
2019 , 前期 , 生化学
2018 , 後期 , 分子細胞生物学
2018 , 後期 , 遺伝と病気
2018 , 後期 , 遺伝子検査学実習

社会活動実績

社会活動等
公開講座
20210904 - , 丸子中央病院オンライン市民公開講座:ニュースでよく聞く「PCR検査」と「抗原検査」