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市川 家國  イチカワ イエクニ

教員組織電話番号
教育組織医学部FAX番号
職名客員教授メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

更新日:2023/06/12

プロフィール

現在の研究課題
糸球体硬化症の急展開
キーワード:ポドサイト , 先天性腎尿路奇形 , 腎疾患の病態生理
所属学会
所属学会
日本腎臓学会
日本小児腎臓病学会
日本小児科学会
日本小児保健協会
American Society of Nephrology
American Federation for Clinical Research
American Physiological Society
Society for Pediatric Research
American Society of Pediatric Nephrology
American Society for Clinical Investigation
American Association of Physicians
学歴
出身学校・専攻等(大学院を除く)
1972 , 慶應義塾大学

取得学位
医学 , 北里大学
受賞学術賞
2007 , Top American Pediatricians
2000 , 日本腎臓財団学術賞

研究活動業績

研究業績(著書・
発表論文等)
論文
Doping Doctors: The Influence of the Marketing Departments of Pharmaceutical Companies on Physician and Researcher Behavior in Japan.
Account Res,23(4):245-53 2016
Author:Ichikawa I, Clayton EW.


Genome-wide association study of IgA nephropathy using 23 465 microsatellite markers in a Japanese population.
J Hum Genet,60(10):573-80 2015(Oct.)
Author:Saka S, Hirawa N, Oka A, Yatsu K, Hirukawa T, Yamamoto R, Matsusaka T, Imai E, Narita I, Endoh M, Ichikawa I, Umemura S, Inoko H.


Unilateral ureteral obstruction attenuates intrarenal angiotensin II generation induced by podocyte injury.
Am J Physiol Renal Physiol,308(8):F932-7 2015(Apr.)
Author:Okabe M, Miyazaki Y, Niimura F, Pastan I, Nishiyama A, Yokoo T, Ichikawa I, Matsusaka T.


Authorship guidelines and actual practice: are they harmonized in different research systems?
J Microbiol Biol Educ,15(2):155-158 2014(Dec.)
Author:Vasconcelos S, Vasgird D, Ichikawa I, Plemmons D


Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensin II generation
Kidney Int,85(5):1068-1077 2014(May)
Author:Matsusaka T, Niimura F, Pastan I, Shintani A, Nishiyama A, Ichikawa I


Mice are unable to endogenously regenerate podocytes during the repair of immunotoxin-induced glomerular injury
Nephrol Dial Transplant,29(5):1005-1012 2014(May)
Author:Miyazaki Y, Shimizu A, Ichikawa I, Hosoya T, Pastan I, Matsusaka T


Kidney Diseases Enhance Expression of Tetraspanin-8: A Possible Protective Effect against Tubular Injury
Nephron Extra,4(1):70-81 2014(Apr.)
Author:Hirukawa T, Wu Q, Sawada K, Matsusaka T, Saka S, Oka A, Hirawa N, Umemura S, Kakuta T, Endoh M, Inoko H, Ichikawa I, Fukagawa M


Foxc1 gene null mutation causes ectopic budding and kidney hypoplasia but not dysplasia
Cells Tissues Organs,198(1):22-27 2013
Author:Komaki F, Miyazaki Y, Niimura F, Matsusaka T, Ichikawa I, Motojima M


Liver Angiotensinogen Is the Primary Source of Renal Angiotensin II
Journal of the American Society of Nephrology,23(7):1181-9 2012(Apr. 19)
Author:Matsusaka T, Niimura F, Shimizu A, Pastan I, Saito A, Kobori H, Nishiyama A, Ichikawa I.
Keywords:angiotensin II/proteinuria/angiotensinogen


Podocyte injury damages other podocytes. Study of genetically engineered chimeric glomeruli.
J Am Soc Nephrol.,22:1275-1285 2011
Author:Matsusaka T, Sandgren E, Shintani A, Kon V, Pastan I, Fogo AB, Ichikawa I.


Glomerular sclerosis is prevented during urinary tract obstruction due to podocyte protection.
Am J Physiol Renal Physiol,300:F792-800 2011
Author:Matsusaka T, Kobayashi K, Kon V, Pastan I, Fogo AB, Ichikawa I.


Induction of podocyte-derived VEGF ameliorates podocyte injury and subsequent abnormal glomerular development caused by puromycin aminonucleoside.
Ped Res,70:83-89 2011
Author:Ma J, Matsusaka T, Yang H-C, Zhong J, Takagi N, Fogo AB, Kon V, Ichikawa I.


Plasma Macromolecules Activate Toll-like receptor 2 and 4 that May Promote Podocyte Injury.
Nephron Exp Nephrol,114:e39-e 2010
Author:Motojima M, Matsusaka T, Ichikawa I.


Angiotensin receptor blocker protection against podocyte-induced sclerosis is podocyte angiotensin II type 1 receptor-Independent.
Hypertension,55:967-973 2010
Author:Matsusaka T, Asano T, Niimura F, Kinomura M, Shimizu A, Shintani A, Pastan I, Fogo AB, Ichikawa I.


Genetic Podocyte Lineage Reveals Progressive Podocytopenia withParietal Cell Hyperplasia in a Murine Model of Cellular/Collapsing Focal Segmental Glomerulosclerosis
Am. J. Pathol.,174(5):1675 - 1682 2009(May 01)
Author:Suzuki T, Matsusaka T, Nakayama M, Asano T, Watanabe T, Ichikawa I, and Nagata M.


The impact of recent revisions in the Japanese ethical guidelines for clinical research.
Asian Bioethics Review 1,1:329-341 2009
Author:Motojima M, Ichikawa I.


Bmp4 podocytes is essential for normal glomerular capillary formation.
J Am Soc Nephrol,19:685-694 2008
Author:Ueda H, Miyazaki Y, Matsusaka T, Utsunomiya Y, Kawamura T, Hosoya T, Ichikawa I.


Megalin participates in the early injury of proximal tubule cells via reabsorption of filtered macromolecules in glomerular disease with non-selective proteinuria.
Kidney Int,74:1262-1269 2008
Author:Motoyoshi Y, Matsusaka T, Saito A, Pastan I, Willnow TE, Mizutani S, Ichikawa I.


Effects of Podocyte Injury on Glomerular Development.
Ped Res,62(4):417-421 2007
Author:Ma J, Rossini M, Yang HC, Zuo Y, Fogo AB, Ichikawa I.


Angiotensin inhibition decreases progression of advanced atherosclerosis and stabilizes established atherosclerotic plaques.
J Am Soc Nephrol.,18:2311-2319 2007
Author:Suganuma E, Babaev VR, Motojima M, Zuo Y, Ayabe N, Fogo AB, Ichikawa I, Linton MF, Fazio S, Kon V.


Inhibition of endogenous BMP in the glomerulus leads to mesangial matrix expansion.
Biochem Biophys Res Commun.,340(2):681-688 2006(Feb. 10)
Author:Miyazaki Y, Ueda H, Yokoo T, Utsunomiya Y, Kawamura T, Matsusaka T, Ichikawa I, Hosoya T


Antiatherogenic effects of angiotensin receptor antagonism in mild renal dysfunction.
J Am Soc Nephrol.,17(2):433-441 2006(Feb.)
Author:Suganuma E, Zuo Y, Ayabe N, Ma J, Babaev VR, Linton MF, Fazio S, Ichikawa I, Fogo AB, Kon V


Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice.
Atherosclerosis.,184(2):312-321 2006(Feb.)
Author:Ayabe N, Babaev VR, Tang Y, Tanizawa T, Fogo AB, Linton MF, Ichikawa I, Fazio S, Kon V


HIV-1 Genes, vpr and nef, synergistically damage podocytes leading to glomerulosclerosis.
J Am Soc Nephrol.,17:2832-2843 2006
Author:Zuo Y, Matsusaka T, Zhong J, Ma J, Ma L, Hanna Z, Jolicoeur P, Fogo AB, Ichikawa I.


Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy.
Kidney Int.,68(3):1048-106 2005(Sep.)
Author:Zhong J, Zuo Y, Ma J, Fogo AB, Jolicoeur P, Ichikawa I, Matsusaka T


Permanent genetic tagging of podocytes: fate of injured podocytes in a mouse model of glomerular sclerosis.
J Am Soc Nephrol.,16(8):2257-2262 2005(Aug.)
Author:Asano T, Niimura F, Pastan I, Fogo AB, Ichikawa I, Matsusaka T


Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury.
J Am Soc Nephrol,16:1013-1023 2005
Author:Matsusaka T, Xin J, Niwa S, Kobayashi K, Akatsuka A, Hashizume H, Wang Q, Pastan I, Fogo AB, Ichikawa I.


Rapid downregulation of beta-actin-based CAG promoter and filamentous actin in injured podocytes.
J Med Dent Sci,52(2):129-134 2005
Author:Asano T, Matsusaka T, Mizutani S, Ichikawa I.


講演・口頭発表等
Toward Global Standardization of Conducting Fair Investigations of Allegations of Research Misconduct
4th 2021 Seoul APR 2021(Feb. 25)
Presenter:市川家國


研究倫理(研究不正の現状と対策)および医療安全 ボトムアップの研究倫理教育 CITI Japanプロジェクトの取組
日本内分泌学会雑誌 92 1 136 2016(Apr.)
Presenter:福嶋義光, 市川家國


グローバルな研究者倫理教育を全ての研究者に
臨床薬理 46 Suppl. S71 2015(Nov.)
Presenter:市川家國

研究費
受託事業
2019 - 2021 , 「医生命学系学会の学会員研究倫理素養の均てん化に向けた学修機会の提供」

教育活動実績

授業等
2012 , 前期 , 臨床決断・社会医学
2012 , 前期 , 生命倫理・医学概論