博士（医学）, 京都大学

医化学, 血管生理学、ペプチド化学

2022年
信州大学学術研究院（医学系）［准教授］

2020年
和歌山県立医科大学医学部［非常勤講師］

2018年
北海道大学大学院総合化学院［客員教授］

2010年 - 2021年
国立循環器病研究センター研究所再生医療部［室長］

2005年 - 2010年
国立循環器病研究センター研究所生化学部［特任研究員]

2004年 - 2006年
慶応義塾大学医学部総合医科学研究センター［特別研究助手］

2002年 - 2004年
京都大学医学部附属病院探索医療センター[助手］

2001年 - 2002年
国立循環器病センター病院内科［専門修練医］

1998年 - 2001年
国立循環器病センター研究所生化学部［レジデント］

1994年 - 1998年
三井記念病院外科［研修医］

1993年 - 1994年
日本医科大学附属病院高度救命救急センター［研修医］

2002年, 京都大学大学院医学研究科

1993年, 宮崎医科大学

2000年
日本内分泌学会学術総会・若手学術奨励賞

Abnormal microscopic findings in the placenta correlate with the severity of fetal heart failure.
Miyoshi T, Matsuyama TA, Nakai M, Miyazato M, Yoshimatsu J, Hatakeyama K, Hosoda H.
Circ J, 87(4), 560-568, 2023年
最終著者, 責任著者

NanoSPECT imaging reveals the uptake of 123I-labeled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36.
Hosomi, K., Kawashima, H., Nakano, A., Kakino, A., Okamatsu-Ogura, Y., Yamashita, Y., Sasaoka, M., Masuda, D., Yamashita, S., Chen, C.H., Yuzuriha, S., Hosoda, H., Iida, H. and Sawamura, T.
Cardiovasc Res, 119(4), 1008-1020, 2023年, 査読有り
責任著者

Effect of ghrelin on the cardiovascular system.
Hosoda H.
Biology, 11(8), 1190, 2022年, 査読有り
筆頭著者, 最終著者, 責任著者

Plasma clearance of intravenous infused adrenomedullin in rats with acute renal failure.
Hosoda H, Nakamura T, Yoshihara F.
BIOMOLECULES, 12(9), 1281, 2022年, 査読有り
筆頭著者, 責任著者

Decreased plasma ghrelin in male ALS patients is associated with poor prognosis.
Nagaoka U, Shimizu T, Uchihara T, Komori T, Hosoda H, Takahashi K.
Neurosci Res, 177, 111-117, 2022年, 査読有り

Utility of perinatal natriuretic peptide for predicting neonatal heart failure.
Miyoshi T, Hosoda H, Miyake A, Sakaguchi H, Kitano M, Kurosaki KI, Shiraishi I, Nakai M, Nishimura K, Miyazato M, Kangawa K, Yoshimatsu J, Minamino N.
Pediatr Int, 64(1), e15231, 2022年, 査読有り

Angiotensin II promotes primary tumor growth and metastasis formation of murine TNBC 4T1 cells through the fibroblasts around cancer cells.
Takiguchi T, Takahashi-Yanaga F, Ishikane S, Tetsuo F, Hosoda H, Arioka M, Kitazono T, Sasaguri T.
Eur J Pharmacol, 909, 174415, 2021年, 査読有り

Combined evaluation of plasma B‑type natriuretic peptide and urinary liver‑type fatty acid‑binding protein/creatinine ratio is related to worsening renal function in patients undergoing elective percutaneous coronary intervention.
Yoshihara F, Hosoda H, Doi T, Yoshida M, Kitamura K, Yamamoto H, Asaumi Y, Ishibashi-Ueda H, Kishida M, Arisato T, Matsuo M, Miyazato M, Yasuda S.
Clin Exp Nephrol, 25(12), 1319-1328, 2021年, 査読有り

Local Action of Neprilysin Exacerbates Pressure Overload Induced Cardiac Remodeling.
Nakagawa H, Kumazawa T, Onoue K, Nakada Y, Nakano T, Ishihara S, Minamino N, Hosoda H, Iwata N, Ueda T, Seno A, Nishida T, Soeda T, Okayama S, Watanabe M, Kawakami R, Saito Y.
Hypertension, 77(6), 1931-1939, 2021年, 査読有り

Plasma natriuretic peptide levels reflect the status of the heart failure in fetuses with arrhythmia.
Miyoshi T, Hosoda H, Kurosaki KI, Shiraishi I, Nakai M, Nishimura K, Miyazato M, Kangawa K, Yoshimatsu J, Minamino N.
J Matern Fetal Neonatal Med, 34(12), 1883-1889, 2021年, 査読有り

Importance of plasma ghrelin levels with special reference to nutritional metabolism and energy expenditure in pediatric patients with severe motor and intellectual disabilities.
Zenitani M, Hosoda H, Nose S, Kangawa K, Kawahara H, Oue Y.
Clin Nutr ESPEN, 42, 180-187, 2021年, 査読有り

Inhibition of fibrotic changes in infrapatellar fat pad alleviates persistent pain and articular cartilage degeneration in monoiodoacetic acid-induced rat arthritis model.
An JS, Tsuji K, Onuma H, Araya N, Isono M, Hoshino T, Inomata K, Hino J, Miyazato M, Hosoda H, Kangawa K, Nakagawa Y, Katagiri H, Miyatake K, Sekiya I, Muneta T, Koga H.
Osteoarthritis Cartilage, 29(3), 380-388, 2021年, 査読有り

Significance of atrial and brain natriuretic peptide measurements in fetuses with heart failure.
Miyoshi T, Hosoda H, Minamino N.
Front Physiol, 12, 654356, 2021年, 査読有り
責任著者

Cancer treatment-related cardiovascular disease: Current status and future research priorities.
Nonaka M, Hosoda H, Uezono Y.
Biochem Pharmacol, 190, 114599, 2021年, 査読有り

Induction of immune tolerance towards allogeneic cells using fetal directed placental injection in a murine model.
Shimazu Y, Endo M, Tamai K, Takahashi K, Miyoshi T, Hosoda H, Flake AW, Kimura T, Yoshimatsu J.
Journal of Stem Cell Research & Therapy, 9(6), 456, 2020年, 査読有り

Maternal administration of tadalafil improves fetal ventricular systolic function in a Hey2 knockout mouse model of fetal heart failure.
Miyoshi T, Hisamitsu T, Ishibashi-Ueda H, Ikemura K, Ikeda T, Miyazato M, Kangawa K, Watanabe Y, Nakagawa O, Hosoda H.
Int J Cardiol, 302, 110-116, 2020年, 査読有り

Dysregulation of ghrelin in diabetes impairs the vascular reparative response to hindlimb ischemia in a mouse model; clinical relevance to peripheral artery disease.
Neale JPH, Pearson JT, Thomas KN, Tsuchimochi H, Hosoda H, Kojima M, Sato T, Jones GT, Denny AP, Daniels LJ, Chandrasekera D, Liu P, van Rij AM, Katare R, Schwenke DO.
Sci Rep, 10(1), 13651, 2020年

Maternal biomarkers for fetal heart failure in fetuses with congenital heart defects or arrhythmias.
Miyoshi T, Hosoda H, Nakai M, Nishimura K, Miyazato M, Kangawa K, Ikeda T, Yoshimatsu J, Minamino N.
Am J Obstet Gynecol, 220(1), 104e1-104e15, 2019年, 査読有り

Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions.
Tachibana R, Umekawa T, Yoshikawa K, Owa T, Magawa S, Furuhashi F, Tsuji M, Maki S, Shimada K, Kaneda MK, Nii M, Tanaka H, Tanaka K, Kamimoto Y, Kondo E, Kato I, Ikemura K, Okuda M, Ma N, Miyoshi T, Hosoda H, Endoh M, Kimura T, Ikeda T.
Sci Rep, 9(1), 234, 2019年, 査読有り

Postoperative decrease in plasma acyl ghrelin levels after pediatric living donor liver transplantation in association with hepatic damage due to ischemia and reperfusion injury.
Zenitani M, Hosoda H, Kodama T, Saka R, Takama Y, Ueno T, Tazuke Y, Kangawa K, Oue T, Okuyama H.
Pediatr Surg Int, 83, 26-32, 2019年, 査読有り

Metabolism of atrial and brain natriuretic peptides in the fetoplacental circulation of fetuses with congenital heart diseases.
Miyoshi T, Hosoda H, Miyazato M, Kangawa K, Yoshimatsu J, Minamino N.
PLACENTA, 83, 26-32, 2019年, 査読有り

Adipocyte-specific expression of C-type natriuretic peptide suppresses lipid metabolism and adipocyte hypertrophy in adipose tissues in mice fed high-fat diet.
Bae CR, Hino J, Hosoda H, Son C, Makino H, Tokudome T, Tomita T, Hosoda K, Miyazato M, Kangawa K.
Sci Rep, 8(1), 2093, 2018年, 査読有り

Ghrelin pre-treatment attenuates local oxidative stress and end organ damage during cardiopulmonary bypass in anesthetized rats.
Sukumaran V, Tsuchimochi H, Fujii Y, Hosoda H, Kangawa K, Akiyama T, Shirai M, Tatsumi E, Pearson JT.
Front Physiol, 9, 196, 2018年, 査読有り

Amniotic fluid natriuretic peptide levels in fetuses with congenital heart defects or arrhythmias.
Miyoshi T, Hosoda H, Umekawa T, Asada T, Fujiwara A, Kurosaki KI, Shiraishi I, Nakai M, Nishimura K, Miyazato M, Kangawa K, Ikeda T, Yoshimatsu J, Minamino N.
Circ J, 82(10), 2619-2626, 2018年, 査読有り

C-type natriuretic peptide (CNP) in endothelial cells attenuates hepatic fibrosis and inflammation in non-alcoholic steatohepatitis.
Bae CR, Hino J, Hosoda H, Miyazato M, Kangawa K.
Life Sci, 209, 349-356, 2018年, 査読有り

Plasma natriuretic peptide levels in fetuses with congenital heart defect and/or arrhythmia.
Miyoshi T, Hosoda H, Umekawa T, Asada T, Fujiwara A, Kurosaki KI, Shiraishi I, Nakai M, Nishimura K, Miyazato M, Kangawa K, Ikeda T, Yoshimatsu J, Minamino N.
Ultrasound Obstet Gynecol, 52(5), 609-616, 2018年, 査読有り

Therapeutic potential of ghrelin and des-acyl ghrelin against chemotherapy-induced cardiotoxicity.
Nonaka M, Kurebayashi N, Murayama T, Sugihara M, Terawaki K, Shiraishi S, Miyano K, Hosoda H, Kishida S, Kangawa K, Sakurai T, Uezono Y..
Endocr J, 64, S35-S39, 2017年, 査読有り

Tadalafil improves L-NG-nitroarginine methyl ester-Induced preeclampsia with fetal growth restriction-Like Symptoms in pregnant mice.
Yoshikawa K, Umekawa T, Maki S, Kubo M, Nii M, Tanaka K, Tanaka H, Osato K, Kamimoto Y, Kondo E, Ikemura K, Okuda M, Katayama K, Miyoshi T, Hosoda H, Ma N, Yoshida T, Ikeda T.
Am J Hypertens, 31(1), 89-96, 2017年, 査読有り

Association of baseline plasma des-acyl ghrelin level with the response to rikkunshito in patients with functional dyspepsia.
Togawa K, Matsuzaki J, Kobayakawa M, Fukushima Y, Suzaki F, Kasugai K, Nishizawa T, Naito Y, Hayakawa T, Kamiya T, Andoh T, Yoshida H, Tokura Y, Nagata H, Mori M, Kato K, Hosoda H, Takebayashi T, Miura S, Uemura N, Joh T, Hibi T, Suzuki H.
J Gastroenterol Hepatol, 31(2), 334-341, 2016年, 査読有り

Comprehensive profiling of GPCR expression in ghrelin-producing cells.
Koyama H, Iwakura H, Dote K, Bando M, Hosoda H, Ariyasu H, Kusakabe T, Son C, Hosoda K, Akamizu T, Kangawa K, Nakao K.
Endocrinology, 157(2), 692-704, 2016年, 査読有り

High incorporation of long-chain fatty acids contributes to the efficient production of acylated ghrelin in ghrelin-producing cells.
Bando M, Iwakura H, Koyama H, Hosoda H, Shigematsu Y, Ariyasu H, Akamizu T, Kangawa K, Nakao K.
FEBS Lett, 590(7), 992-1001, 2016年, 査読有り

Improvement of cisplatin-related renal dysfunction by synthetic ghrelin: a prospective randomised phase II trial.
Yanagimoto Y, Takiguchi S, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Hosoda H, Kangawa K, Mori M, Doki Y.
Br J Cancer, 114(12), 1318-1325, 2016年, 査読有り

Effect of basal insulin therapy on vascular endothelial function and adipokine profiles in people with Type 2 diabetes.
Makino H, Tanaka A, Hosoda H, Koezuka R, Tochiya M, Ohata Y, Tamanaha T, Miyamoto Y, Kangawa K, Kishimoto I.
Diabet Med, 33(12), 1737-1743, 2016年, 査読有り

Impact of synthetic ghrelin administration for patients with severe body weight reduction more than 1 year after gastrectomy: a phase II clinical trial.
Takiguchi S, Miyazaki Y, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Miyata H, Hosoda H, Kangawa K, Mori M, Doki Y.
Surg Today, 46(3), 379-385, 2016年, 査読有り

Identification of activated protein C as a ghrelin endopeptidase in bovine plasma.
Satou M, Nishi Y, Hishinuma A, Hosoda H, Kangawa K, Sugimoto H.
J Endocrinol, 224(1), 61-73, 2015年, 査読有り

Moderate maternal food restriction in mice impairs physical growth, behavior, and neurodevelopment of offspring.
Akitake Y, Katsuragi S, Hosokawa M, Mishima K, Ikeda T, Miyazato M, Hosoda H.
Nutr Res, 35(1), 76-87, 2015年, 査読有り

Immune tolerance induction using fetal directed placental injection in rodent models: a murine model.
Takahashi K, Endo M, Miyoshi T, Tsuritani M, Shimazu Y, Hosoda H, Saga K, Tamai K, Flake AW, Yoshimatsu J, Kimura T.
PLOS ONE, 10(4), e0123712, 2015年, 査読有り

Postnatal weight gain induced by overfeeding pups and maternal high-fat diet during the lactation period modulates glucose metabolism and the production of pancreatic and gastrointestinal peptides.
Du Q, Hosoda H, Umekawa T, Kinouchi T, Ito N, Miyazato M, Kangawa K, Ikeda T.
PEPTIDES, 70, 23-31, 2015年, 査読有り

Establishment and characterization of a novel orthotopic mouse model for human uterine sarcoma with different metastatic potentials.
Kawabe S, Mizutani T, Ishikane S, Martinez ME, Kiyono Y, Miura K, Hosoda H, Imamichi Y, Kangawa K, Miyamoto K, Yoshida Y.
Cancer Lett, 366(2), 182-190, 2015年, 査読有り

Randomized clinical trial: rikkunshito in the treatment of functional dyspepsia--a multicenter, double-blind, randomized, placebo-controlled study.
Suzuki H, Matsuzaki J, Fukushima Y, Suzaki F, Kasugai K, Nishizawa T, Naito Y, Hayakawa T, Kamiya T, Andoh T, Yoshida H, Tokura Y, Nagata H, Kobayakawa M, Mori M, Kato K, Hosoda H, Takebayashi T, Miura S, Uemura N, Joh T, Hibi T, Tack J; Rikkunshito study group.
Neurogastroenterol Motil, 24(7), 950-961, 2014年, 査読有り

Relation between circulating levels of GH, IGF-1, ghrelin and somatic growth in Rett syndrome.
Hara M, Nishi Y, Yamashita Y, Hirata R, Takahashi S, Nagamitsu S, Hosoda H, Kangawa K, Kojima M, Matsuishi T.
Brain Dev, 36(9), 794-800, 2014年, 査読有り

Survival benefit of ghrelin in the heart failure due to dilated cardiomyopathy.
Du CK, Zhan DY, Morimoto S, Akiyama T, Schwenke DO, Hosoda H, Kangawa K, Shirai M.
Pharmacol Res Perspect, 2(5), e00064, 2014年, 査読有り

Serum ghrelin levels partially recover with the recovery of appetite and food intake after total gastrectomy.
Koizumi M, Hosoya Y, Dezaki K, Yada T, Hosoda H, Kangawa K, Nagai H, Lefor AT, Sata N, Yasuda Y.
Surg Today, 44(11), 2131-2137, 2014年, 査読有り

Effect of rikkunshito, a Japanese herbal medicine, on gastrointestinal symptoms and ghrelin levels in gastric cancer patients after gastrectomy.
Takiguchi S, Hiura Y, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Miyata H, Mori M, Hosoda H, Kangawa K, Doki Y.
Gastric Cancer, 16(2), 167-174, 2013年

Changes in subcellular distribution of n-octanoyl or n-decanoyl ghrelin in ghrelin-producing cells.
Nishi Y, Mifune H, Yabuki A, Tajiri Y, Hirata R, Tanaka E, Hosoda H, Kangawa K, Kojima M.
Front Endocrinol (Lausanne), 4, 84, 2013年

Hexarelin treatment in male ghrelin knockout mice after myocardial infarction.
Mao Y, Tokudome T, Kishimoto I, Otani K, Hosoda H, Nagai C, Minamino N, Miyazato M, Kangawa K.
Endocrinology, 154(10), 3847-3854, 2013年

Allogeneic transplantation of fetal membrane-derived mesenchymal stem cell sheets increases neovascularization and improves cardiac function after myocardial infarction in rats.
Ishikane S, Hosoda H, Yamahara K, Akitake Y, Kyoungsook J, Mishima K, Iwasaki K, Fujiwara M, Miyazato M, Kangawa K, Ikeda T.
TRANSPLANTATION, 96(8), 697-706, 2013年

Decreased serum ghrelin levels in patients with acute myocardial infarction.
Matsumoto M, Yasuda S, Miyazaki S, Kataoka Y, Hosoda H, Nagaya N, Noguchi T, Morii I, Ogawa H, Kangawa K.
Tohoku J Exp Med, 231(3), 235-242, 2013年, 査読有り

Analysis of plasma ghrelin in patients with medium-chain acyl-CoA dehydrogenase deficiency and glutaric aciduria type II.
Akamizu T, Sakura N, Shigematsu Y, Tajima G, Ohtake A, Hosoda H, Iwakura H, Ariyasu H, Kangawa K.
Eur J Endocrinol, 166(2), 235-240, 2012年

Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivo.
Bando M, Iwakura H, Ariyasu H, Hosoda H, Yamada G, Hosoda K, Adachi S, Nakao K, Kangawa K, Akamizu T.
Am J Physiol Endocrinol Metab, 302(4), E403-408, 2012年

Increased production of active ghrelin is relevant to hyperphagia in nonobese spontaneously diabetic Torii rats.
Mifune H, Nishi Y, Tajiri Y, Masuyama T, Hosoda H, Kangawa K, Kojima M.
Metabolism, 61(4), 491-495, 2012年

Enhanced gastric ghrelin production and secretion in rats with gastric outlet obstruction.
Iwasaki E, Suzuki H, Masaoka T, Nishizawa T, Hosoda H, Kangawa K, Hibi T.
Dig Dis Sci, 57(4), 858-864, 2012年

Disrupted regulation of ghrelin production under antihypertensive treatment in spontaneously hypertensive rats.
Hamada N, Nishi Y, Tajiri Y, Setoyama K, Kamimura R, Miyahara K, Nuruki N, Hosoda H, Kangawa K, Kojima M, Mifune H.
Circ J, 76(6), 1423-1429, 2012年

Ghrelin prevents incidence of malignant arrhythmia after acute myocardial infarction through vagal afferent nerves.
Mao Y, Tokudome T, Otani K, Kishimoto I, Nakanishi M, Hosoda H, Miyazato M, Kangawa K.
Endocrinology, 153(7), 3426-3434, 2012年

Plasma levels of n-decanoyl ghrelin, another acyl- and active-form of ghrelin, in human subjects and the effect of glucose- or meal-ingestion on its dynamics.
Yoh J, Nishi Y, Hosoda H, Tajiri Y, Yamada K, Yanase T, Doi R, Yonemoto K, Kangawa K, Kojima M, Tanaka E, Kusukawa J.
J. Regul Pept, 167(1), 140-148, 2011年

Postoperative weight loss does not resolve after esophagectomy despite normal serum ghrelin levels.
Koizumi M, Hosoya Y, Dezaki K, Yada T, Hosoda H, Kangawa K, Nagai H, Lefor AT, Sata N, Yasuda Y.
Ann Thorac Surg, 91(4), 1032-1037, 2011年

PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure.
Cao Y, Nakata M, Okamoto S, Takano E, Yada T, Minokoshi Y, Hirata Y, Nakajima K, Iskandar K, Hayashi Y, Ogawa W, Barsh GS, Hosoda H, Kangawa K, Itoh H, Noda T, Kasuga M, Nakae J.
PLOS ONE, 6(4), e18324, 2011年

Oxytocin and dopamine stimulate ghrelin secretion by the ghrelin-producing cell line, MGN3-1 in vitro.
Iwakura H, Ariyasu H, Hosoda H, Yamada G, Hosoda K, Nakao K, Kangawa K, Akamizu T.
Endocrinology, 152(7), 2619-2625, 2011年

Centrally administered ghrelin activates cardiac vagal nerve in anesthetized rabbits.
Shimizu S, Akiyama T, Kawada T, Sonobe T, Kamiya A, Shishido T, Tokudome T, Hosoda H, Shirai M, Kangawa K, Sugimachi M.
Auton Neurosci, 162(1-2), 60-65, 2011年

Correlation between plasma or mucosal ghrelin levels and chronic gastritis.
Ikeda K, Chiba T, Sugai T, Kangawa K, Hosoda H, Suzuki K.
Hepatogastroenterology, 58(110-111), 1622-1627, 2011年

Ghrelin levels are reduced in Rett syndrome patients with eating difficulties.
Hara M, Nishi Y, Yamashita Y, Yoh J, Takahashi S, Nagamitsu S, Kakuma T, Hosoda H, Kangawa K, Kojima M, Matsuishi T.
Int J Dev Neurosci, 29(8), 899-902, 2011年

Establishment of a novel ghrelin-producing cell line.
Iwakura H, Li Y, Ariyasu H, Hosoda H, Kanamoto N, Bando M, Yamada G, Hosoda K, Nakao K, Kangawa K, Akamizu T.
Endocrinology, 151(6), 2940-2945, 2010年

Effects of ghrelin administration after total gastrectomy: a prospective, randomized, placebo-controlled phase II study.
Adachi S, Takiguchi S, Okada K, Yamamoto K, Yamasaki M, Miyata H, Nakajima K, Fujiwara Y, Hosoda H, Kangawa K, Mori M, Doki Y.
GASTROENTEROLOGY, 138(4), 1312-1320, 2010年

Dynamics of placental ghrelin production and its receptor expression in a Dahl salt-sensitive rat model of intrauterine growth restriction.
Nonoshita A, Nishi Y, Takushima S, Oshima M, Hosoda H, Kangawa K, Kojima M, Mifune H, Tanaka E, Hori D, Kamura T.
PLACENTA, 31(5), 358-364, 2010年

Reconstruction-dependent recovery from anorexia and time-related recovery of regulatory ghrelin system in gastrectomized rats.
Koizumi M, Dezaki K, Hosoda H, Damdindorj B, Sone H, Ming L, Hosoya Y, Sata N, Kobayashi E, Kangawa K, Nagai H, Yasuda Y, Yada T.
Int J Pept, 2010, 365416, 2010年

Allogenic fetal membrane-derived mesenchymal stem cells contribute to renal repair in experimental glomerulonephritis.
Tsuda H, Yamahara K, Ishikane S, Otani K, Nakamura A, Sawai K, Ichimaru N, Sada M, Taguchi A, Hosoda H, Tsuji M, Kawachi H, Horio M, Isaka Y, Kangawa K, Takahara S, Ikeda T.
Am J Physiol Renal Physiol, 299(5), F1004-1013, 2010年

Generation of transgenic mice overexpressing a ghrelin analog.
Yamada G, Ariyasu H, Iwakura H, Hosoda H, Akamizu T, Nakao K, Kangawa K.
Endocrinology, 151(12), 5935-5940, 2010年

Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents.
Hiejima H, Nishi Y, Hosoda H, Yoh J, Mifune H, Satou M, Sugimoto H, Chiba S, Kawahara Y, Tanaka E, Yoshimatsu H, Uchimura N, Kangawa K, Kojima M.
Regul Pept, 156(1-3), 47-56, 2009年

Suppression of experimental autoimmune encephalomyelitis by ghrelin.
Theil MM, Miyake S, Mizuno M, Tomi C, Croxford JL, Hosoda H, Theil J, von Hörsten S, Yokote H, Chiba A, Lin Y, Oki S, Akamizu T, Kangawa K, Yamamura T.
J Immunol, 183(4), 2859-2866, 2009年

A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance.
Iwakura H, Ariyasu H, Li Y, Kanamoto N, Bando M, Yamada G, Hosoda H, Hosoda K, Shimatsu A, Nakao K, Kangawa K, Akamizu T.
Am J Physiol Endocrinol Metab, 297(3), E802-811, 2009年

Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats.
Schwenke DO, Tokudome T, Shirai M, Hosoda H, Horio T, Kishimoto I, Kangawa K.
Endocrinology, 149(1), 237-244, 2008年

Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction.
Soeki T, Kishimoto I, Schwenke DO, Tokudome T, Horio T, Yoshida M, Hosoda H, Kangawa K.
Am J Physiol Heart Circ Physiol, 294(1), H426-432, 2008年

The autonomic nervous system regulates gastric ghrelin secretion in rats.
Hosoda H, Kangawa K.
Regul Pept, 146(1-3), 12-18, 2008年

Ghrelin stimulates milk intake by affecting adult type feeding behaviour in postnatal rats.
Piao H, Hosoda H, Kangawa K, Murata T, Narita K, Higuchi T.
J Neuroendocrinol, 20(3), 330-334, 2008年

Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite.
Akamizu T, Iwakura H, Ariyasu H, Hosoda H, Murayama T, Yokode M, Teramukai S, Seno H, Chiba T, Noma S, Nakai Y, Fukunaga M, Nakai Y, Kangawa K; FD Clinical Study Team.
Eur J Endocrinol, 158(4), 491-498, 2008年

Decreased levels of ghrelin, cortisol, and fasting blood sugar, but not n-octanoylated ghrelin, in Japanese schizophrenic inpatients treated with olanzapine.
Tanaka K, Morinobu S, Ichimura M, Asakawa A, Inui A, Hosoda H, Kangawa K, Yamawaki S.
Prog Neuropsychopharmacol Biol Psychiatry, 32(6), 1527-1532, 2008年

Decreased levels of adiponectin in obese patients with gastroesophageal reflux evaluated by videoesophagography: possible relationship between gastroesophageal reflux and metabolic syndrome.
Iwasaki E, Suzuki H, Sugino Y, Iida T, Nishizawa T, Masaoka T, Hosoda H, Kangawa K, Hibi T.
J Gastroenterol Hepatol, 2(S216), 221, 2008年

Glucose and lipid metabolism of long-term risperidone monotherapy in patients with schizophrenia.
Murashita M, Inoue T, Kusumi I, Nakagawa S, Itoh K, Tanaka T, Izumi T, Hosoda H, Kangawa K, Koyama T.
Psychiatry Clin Neurosci, 61(1), 54-58, 2007年

Identification of a ghrelin-like peptide in two species of shark, Sphyrna lewini and Carcharhinus melanopterus.
Kawakoshi A, Kaiya H, Riley LG, Hirano T, Grau EG, Miyazato M, Hosoda H, Kangawa K.
Gen Comp Endocrinol, 151(3), 259-268, 2007年

Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH.
Kawamata T, Inui A, Hosoda H, Kangawa K, Hori T.
Clin Endocrinol (Oxf), 67(1), 140-144, 2007年

Acute administration of clozapine concurrently increases blood glucose and circulating plasma ghrelin levels in rats.
Murashita M, Kusumi I, Hosoda H, Kangawa K, Koyama T.
Psychoneuroendocrinology, 32(7), 777-784, 2007年

Enhanced ghrelin expression and subsequent acid secretion in mice with genetic H(2)-receptor knockout.
Arakawa M, Suzuki H, Minegishi Y, Fukushima Y, Masaoka T, Ishikawa T, Hosoda H, Kangawa K, Hibi T.
J Gastroenterol, 42(9), 711-718, 2007年

Postoperative ghrelin levels and delayed recovery from body weight loss after distal or total gastrectomy.
Takachi K, Doki Y, Ishikawa O, Miyashiro I, Sasaki Y, Ohigashi H, Murata K, Nakajima H, Hosoda H, Kangawa K, Sasakuma F, Imaoka S.
J Surg Res, 130(1), 1-7, 2006年

Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure.
Akamizu T, Murayama T, Teramukai S, Miura K, Bando I, Irako T, Iwakura H, Ariyasu H, Hosoda H, Tada H, Matsuyama A, Kojima S, Wada T, Wakatsuki Y, Matsubayashi K, Kawakita T, Shimizu A, Fukushima M, Yokode M, Kangawa K.
J Endocrinol, 188(2), 333-344, 2006年

Maternal ghrelin plays an important role in rat fetal development during pregnancy.
Nakahara K, Nakagawa M, Baba Y, Sato M, Toshinai K, Date Y, Nakazato M, Kojima M, Miyazato M, Kaiya H, Hosoda H, Kangawa K, Murakami N.
Endocrinology, 147(3), 1333-1342, 2006年

Ghrelin prevents development of diabetes at adult age in streptozotocin-treated newborn rats.
Irako T, Akamizu T, Hosoda H, Iwakura H, Ariyasu H, Tojo K, Tajima N, Kangawa K.
DIABETOLOGIA, 49(6), 1264-1273, 2006年

Ghrelin reduction after esophageal substitution and its correlation to postoperative body weight loss in esophageal cancer patients.
Doki Y, Takachi K, Ishikawa O, Miyashiro I, Sasaki Y, Ohigashi H, Nakajima H, Hosoda H, Kangawa K, Sasakuma F, Motoori M, Imaoka S.
SURGERY, 39(6), 797-805, 2006年

A role of the histaminergic system for the control of feeding by orexigenic peptides.
Ishizuka T, Nomura S, Hosoda H, Kangawa K, Watanabe T, Yamatodani A.
Physiol Behav, 89(3), 295-300, 2006年

Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance.
Dezaki K, Sone H, Koizumi M, Nakata M, Kakei M, Nagai H, Hosoda H, Kangawa K, Yada T.
DIABETES, 55(12), 3486-3493, 2006年

Transgenic mice overexpressing des-acyl ghrelin show small phenotype.
Ariyasu H, Takaya K, Iwakura H, Hosoda H, Akamizu T, Arai Y, Kangawa K, Nakao K.
Endocrinology, 146(1), 355-364, 2005年

Influencing the between-feeding and endocrine responses of plasma ghrelin in healthy dogs.
Yokoyama M, Nakahara K, Kojima M, Hosoda H, Kangawa K, Murakami N.
Eur J Endocrinol, 152(1), 155-160, 2005年

Olanzapine increases plasma ghrelin level in patients with schizophrenia.
Murashita M, Kusumi I, Inoue T, Takahashi Y, Hosoda H, Kangawa K, Koyama T.
Psychoneuroendocrinology, 30(1), 106-110, 2005年

Long-term strict monitoring of plasma ghrelin and other serological markers of gastric diseases after Helicobacter pylori eradication.
Masaoka T, Suzuki H, Imaeda H, Hosoda H, Ohara T, Morishita T, Ishii H, Kangawa K, Hibi T.
Hepatogastroenterology, 52(61), 1-4, 2005年

Plasma concentrations of adrenomedullin and ghrelin in hemodialysis patients with sustained and episodic hypotension.
Iwanaga K, Takamura N, Abe Y, Zhaojia Y, Shinzato K, Hosoda H, Kangawa K, Ohtsuru A, Kohno S, Yamashita S, Aoyagi K.
Endocr J, 52(1), 23-28, 2005年

Effects of ghrelin on growth hormone secretion in vivo in ruminants.
Hashizume T, Horiuchi M, Nonaka S, Kasuya E, Kojima M, Hosoda H, Kangawa K.
Regul Pept, 126(1-2), 61-65, 2005年

Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice.
Iwakura H, Hosoda K, Son C, Fujikura J, Tomita T, Noguchi M, Ariyasu H, Takaya K, Masuzaki H, Ogawa Y, Hayashi T, Inoue G, Akamizu T, Hosoda H, Kojima M, Itoh H, Toyokuni S, Kangawa K, Nakao K.
J Biol Chem, 280(15), 15247-15256, 2005年

Different effects of peripheral and central ghrelin on regulation of food intake in the Japanese quail.
Shousha S, Nakahara K, Kojima M, Miyazato M, Hosoda H, Kangawa K, Murakami N.
Gen Comp Endocrinol, 141(2), 178-183, 2005年

Concentration of the n-octanoylated active form of ghrelin in fetal and neonatal circulation.
Yokota I, Kitamura S, Hosoda H, Kotani Y, Kangawa K.
Endocr J, 52(2), 271-276, 2005年

Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin.
Nishi Y, Hiejima H, Hosoda H, Kaiya H, Mori K, Fukue Y, Yanase T, Nawata H, Kangawa K, Kojima M.
Endocrinology, 146(5), 2255-2264, 2005年

Enhanced ghrelin secretion in rats with cysteamine-induced duodenal ulcers.
Fukuhara S, Suzuki H, Masaoka T, Arakawa M, Hosoda H, Minegishi Y, Kangawa K, Ishii H, Kitajima M, Hibi T.
Am J Physiol Gastrointest Liver Physiol, 289(1), G138-145, 2005年

Enhanced plasma ghrelin levels in Helicobacter pylori-colonized, interleukin-1-receptor type 1-homozygous knockout (IL-1R1-/-) mice.
Abiko Y, Suzuki H, Masaoka T, Nomura S, Kurabayashi K, Hosoda H, Kangawa K, Hibi T.
World J Gastroenterol, 11(27), 4148-4153, 2005年

Purification, cDNA cloning, and characterization of ghrelin in channel catfish, Ictalurus punctatus.
Kaiya H, Small BC, Bilodeau AL, Shepherd BS, Kojima M, Hosoda H, Kangawa K.
Gen Comp Endocrinol, 143(3), 2005年

Short-term secretory regulation of ghrelin during growth hormone provocative tests in prepubertal children with various growth hormone secretory capacities.
Matsuoka H, Hosoda H, Sugawara H, Iwama S, Kim HS, Kangawa K, Sugihara S.
Horm Res, 64(6), 274-279, 2005年

Relationship between growth and plasma concentrations of ghrelin and growth hormone in juvenile beagle dogs.
Yokoyama M, Murakami N, Naganobu K, Hosoda H, Kangawa K, Nakahara K.
J Vet Med Sci, 67(11), 1189-1192, 2005年

Regulation of ghrelin secretion during pregnancy and lactation in the rat: possible involvement of hypothalamus.
Shibata K, Hosoda H, Kojima M, Kangawa K, Makino Y, Makino I, Kawarabayashi T, Futagami K, Gomita Y.
PEPTIDES, 25(2), 279-287, 2004年

Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects.
Akamizu T, Takaya K, Irako T, Hosoda H, Teramukai S, Matsuyama A, Tada H, Miura K, Shimizu A, Fukushima M, Yokode M, Tanaka K, Kangawa K.
Eur J Endocrinol, 150(4), 447-455, 2004年

Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples.
Hosoda H, Doi K, Nagaya N, Okumura H, Nakagawa E, Enomoto M, Ono F, Kangawa K.
Clin Chem, 50(6), 1077-1080, 2004年

Short-term secretory regulation of the active form of ghrelin and total ghrelin during an oral glucose tolerance test in patients with anorexia nervosa.
Nakai Y, Hosoda H, Nin K, Ooya C, Hayashi H, Akamizu T, Kangawa K.
Eur J Endocrinol, 150(6), 913-914, 2004年

Structural determination and histochemical localization of ghrelin in the red-eared slider turtle, Trachemys scripta elegans.
Kaiya H, Sakata I, Kojima M, Hosoda H, Sakai T, Kangawa K.
Gen Comp Endocrinol, 138(1), 50-57, 2004年

Genomic structure and characterization of the 5'-flanking region of the human ghrelin gene.
Kanamoto N, Akamizu T, Tagami T, Hataya Y, Moriyama K, Takaya K, Hosoda H, Kojima M, Kangawa K, Nakao K.
Endocrinology, 145(9), 4144-4153, 2004年

Plasma ghrelin concentration correlates with the levels of serum pepsinogen I and pepsinogen I/II ratio--a possible novel and non-invasive marker for gastric atrophy.
Suzuki H, Masaoka T, Hosoda H, Nomura S, Ohara T, Kangawa K, Ishii H, Hibi T.
Hepatogastroenterology, 51(59), 1249-1254, 2004年

Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease.
Itoh T, Nagaya N, Yoshikawa M, Fukuoka A, Takenaka H, Shimizu Y, Haruta Y, Oya H, Yamagishi M, Hosoda H, Kangawa K, Kimura H.
Am J Respir Crit Care Med, 170(8), 879-882, 2004年

Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway.
Hanada R, Teranishi H, Pearson JT, Kurokawa M, Hosoda H, Fukushima N, Fukue Y, Serino R, Fujihara H, Ueta Y, Ikawa M, Okabe M, Murakami N, Shirai M, Yoshimatsu H, Kangawa K, Kojima M.
Nat Med, 10(10), 1067-1073, 2004年

Intravenous administration of ghrelin stimulates growth hormone secretion in vagotomized patients as well as normal subjects.
Takeno R, Okimura Y, Iguchi G, Kishimoto M, Kudo T, Takahashi K, Takahashi Y, Kaji H, Ohno M, Ikuta H, Kuroda Y, Obara T, Hosoda H, Kangawa K, Chihara K.
Eur J Endocrinol, 151(4), 447-450, 2004年

Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents.
Dezaki K, Hosoda H, Kakei M, Hashiguchi S, Watanabe M, Kangawa K, Yada T.
DIABETES, 53(12), 3142-3151, 2004年

Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing.
Hosoda H, Kojima M, Mizushima T, Shimizu S, Kangawa K.
J Biol Chem, 278(1), 64-70, 2003年

Circulating ghrelin concentrations are reduced in healthy offspring of Type 2 diabetic subjects, and are increased in women independent of a family history of Type 2 diabetes.
Østergård T, Hansen TK, Nyholm B, Gravholt CH, Djurhuus CB, Hosoda H, Kangawa K, Schmitz O.
DIABETOLOGIA, 46(1), 134-136, 2003年

Increased plasma ghrelin level in lung cancer cachexia
Shimizu Y, Nagaya N, Isobe T, Imazu M, Okumura H, Hosoda H, Kojima M, Kangawa K, Kohno N.
Clin Cancer Res, 9(2), 774-778, 2003年

Amidated fish ghrelin: purification, cDNA cloning in the Japanese eel and its biological activity.
Kaiya H, Kojima M, Hosoda H, Riley LG, Hirano T, Grau EG, Kangawa K.
J Endocrinol, 176(3), 2003年

The role of circulating ghrelin in growth hormone (GH) secretion in freely moving male rats.
Okimura Y, Ukai K, Hosoda H, Murata M, Iguchi G, Iida K, Kaji H, Kojima M, Kangawa K, Chihara K.
Life Sci, 72(22), 2517-2524, 2003年

Effect of chronic treatments with ghrelin on milk secretion in lactating rats.
Nakahara K, Hayashida T, Nakazato M, Kojima M, Hosoda H, Kangawa K, Murakami N.
Biochem Biophys Res Commun, 303(3), 751-755, 2003年

Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes.
Masaoka T, Suzuki H, Hosoda H, Ota T, Minegishi Y, Nagata H, Kangawa K, Ishii H.
FEBS Lett, 541(1-3), 64-68, 2003年

Effects of ghrelin on growth hormone secretion from cultured adenohypophysial cells in cattle.
Hashizume T, Horiuchi M, Tate N, Nonaka S, Kojima M, Hosoda H, Kangawa K.
Endocr J, 50(3), 289-295, 2003年

Identification of tilapia ghrelin and its effects on growth hormone and prolactin release in the tilapia, Oreochromis mossambicus.
Kaiya H, Kojima M, Hosoda H, Riley LG, Hirano T, Grau EG, Kangawa K.
Comp Biochem Physiol B Biochem Mol Biol., 135(3), 421-429, 2003年

Cardiovascular and hormonal effects of subcutaneous administration of ghrelin, a novel growth hormone-releasing peptide, in healthy humans.
Enomoto M, Nagaya N, Uematsu M, Okumura H, Nakagawa E, Ono F, Hosoda H, Oya H, Kojima M, Kanmatsuse K, Kangawa K.
Clin Sci (Lond), 105(4), 431-435, 2003年

Ghrelin concentration in cord and neonatal blood: relation to fetal growth and energy balance.
Kitamura S, Yokota I, Hosoda H, Kotani Y, Matsuda J, Naito E, Ito M, Kangawa K, Kuroda Y.
J Clin Endocrinol Metab, 88(11), 5473-5477, 2003年

Alterations of plasma ghrelin levels in rats with lipopolysaccharide-induced wasting syndrome and effects of ghrelin treatment on the syndrome.
Hataya Y, Akamizu T, Hosoda H, Kanamoto N, Moriyama K, Kangawa K, Takaya K, Nakao K.
Endocrinology, 144(12), 5365-5371, 2003年

Peptide purification, complementary deoxyribonucleic acid (DNA) and genomic DNA cloning, and functional characterization of ghrelin in rainbow trout.
Kaiya H, Kojima M, Hosoda H, Moriyama S, Takahashi A, Kawauchi H, Kangawa K.
Endocrinology, 144(12), 5215-5226, 2003年

Plasma levels of active form of ghrelin during oral glucose tolerance test in patients with anorexia nervosa.
Nakai Y, Hosoda H, Nin K, Ooya C, Hayashi H, Akamizu T, Kangawa K.
Eur J Endocrinol, 149(1), R1-3, 2003年

Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion.
Date Y, Nakazato M, Hashiguchi S, Dezaki K, Mondal MS, Hosoda H, Kojima M, Kangawa K, Arima T, Matsuo H, Yada T, Matsukura S.
DIABETES, 51(1), 124-129, 2002年

Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion.
Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, Nozoe S, Hosoda H, Kangawa K, Matsukura S.
J Clin Endocrinol Metab, 87(1), 240-244, 2002年

Weight loss increases circulating levels of ghrelin in human obesity.
Hansen TK, Dall R, Hosoda H, Kojima M, Kangawa K, Christiansen JS, Jørgensen JO.
Clin Endocrinol (Oxf), 56(2), 203-206, 2002年

Alteration of plasma ghrelin levels associated with the blood pressure in pregnancy.
Makino Y, Hosoda H, Shibata K, Makino I, Kojima M, Kangawa K, Kawarabayashi T.
Hypertension, 39(3), 781-784, 2002年

Plasma ghrelin levels during exercise in healthy subjects and in growth hormone-deficient patients.
Dall R, Kanaley J, Hansen TK, Møller N, Christiansen JS, Hosoda H, Kangawa K, Jørgensen JO.
Eur J Endocrinol, 147(1), 65-70, 2002年

Circulating levels of ghrelin and GLP-1 are inversely related during glucose ingestion.
Djurhuus CB, Hansen TK, Gravholt C, Ørskov L, Hosoda H, Kangawa K, Jørgensen JO, Holst JJ, Schmitz O.
Horm Metab Res, 34(7), 411-413, 2002年

Hyperglycaemia suppresses the secretion of ghrelin, a novel growth-hormone-releasing peptide: responses to the intravenous and oral administration of glucose.
Nakagawa E, Nagaya N, Okumura H, Enomoto M, Oya H, Ono F, Hosoda H, Kojima M, Kangawa K.
Clin Sci (Lond), 103(3), 325-328, 2002年

Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin.
Ariyasu H, Takaya K, Hosoda H, Iwakura H, Ebihara K, Mori K, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K.
Endocrinology, 143(9), 3341-3350, 2002年

Chicken ghrelin: purification, cDNA cloning, and biological activity.
Kaiya H, Van Der Geyten S, Kojima M, Hosoda H, Kitajima Y, Matsumoto M, Geelissen S, Darras VM, Kangawa K.
Endocrinology, 143(9), 3454-3463, 2002年

Ghrelin immunoreactivity in human plasma is suppressed by somatostatin.
Nørrelund H, Hansen TK, Ørskov H, Hosoda H, Kojima M, Kangawa K, Weeke J, Møller N, Christiansen JS, Jørgensen JO.
Clin Endocrinol (Oxf), 57(4), 539-546, 2002年

Plasma ghrelin and desacyl ghrelin concentrations in renal failure.
Yoshimoto A, Mori K, Sugawara A, Mukoyama M, Yahata K, Suganami T, Takaya K, Hosoda H, Kojima M, Kangawa K, Nakao K.
J Am Soc Nephrol, 13(11), 2748-2752, 2002年

Ghrelin expression in islet cell tumors: augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I.
Iwakura H, Hosoda K, Doi R, Komoto I, Nishimura H, Son C, Fujikura J, Tomita T, Takaya K, Ogawa Y, Hayashi T, Inoue G, Akamizu T, Hosoda H, Kojima M, Kangawa K, Imamura M, Nakao K.
J Clin Endocrinol Metab, 87(11), 4885-4888, 2002年

Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents.
Ikezaki A, Hosoda H, Ito K, Iwama S, Miura N, Matsuoka H, Kondo C, Kojima M, Kangawa K, Sugihara S.
DIABETES, 51(12), 3408-3411, 2002年

Hemodynamic and hormonal effects of human ghrelin in healthy volunteers.
Nagaya N, Kojima M, Uematsu M, Yamagishi M, Hosoda H, Oya H, Hayashi Y, Kangawa K.
Am J Physiol Regul Integr Comp Physiol, 280(5), R1483-1487, 2001年

Structural similarity of ghrelin derivatives to peptidyl growth hormone secretagogues.
Matsumoto M, Kitajima Y, Iwanami T, Hayashi Y, Tanaka S, Minamitake Y, Hosoda H, Kojima M, Matsuo H, Kangawa K.
Biochem Biophys Res Commun, 284(3), 655-659, 2001年

Structure-activity relationship of ghrelin: pharmacological study of ghrelin peptides.
Matsumoto M, Hosoda H, Kitajima Y, Morozumi N, Minamitake Y, Tanaka S, Matsuo H, Kojima M, Hayashi Y, Kangawa K.
Biochem Biophys Res Commun, 287(1), 142-146, 2001年

Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans.
Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, Suda M, Koh T, Natsui K, Toyooka S, Shirakami G, Usui T, Shimatsu A, Doi K, Hosoda H, Kojima M, Kangawa K, Nakao K.
J Clin Endocrinol Metab, 86(10), 4753-4758, 2001年

Substantial production of ghrelin by a human medullary thyroid carcinoma cell line.
Kanamoto N, Akamizu T, Hosoda H, Hataya Y, Ariyasu H, Takaya K, Hosoda K, Saijo M, Moriyama K, Shimatsu A, Kojima M, Kangawa K, Nakao K.
J Clin Endocrinol Metab, 86(10), 4984-4990, 2001年

Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors.
Nagaya N, Uematsu M, Kojima M, Date Y, Nakazato M, Okumura H, Hosoda H, Shimizu W, Yamagishi M, Oya H, Koh H, Yutani C, Kangawa K.
Circulation, 104(17), 2034-2038, 2001年

Enhanced exercise-induced GH secretion in subjects with Pro7 substitution in the prepro-NPY.
Kallio J, Pesonen U, Karvonen MK, Kojima M, Hosoda H, Kangawa K, Koulu M.
J Clin Endocrinol Metab, 86(11), 5348-5352, 2001年

Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue.
Kaiya H, Kojima M, Hosoda H, Koda A, Yamamoto K, Kitajima Y, Matsumoto M, Minamitake Y, Kikuyama S, Kangawa K.
J Biol Chem, 276(44), 40441-40448, 2001年

Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure.
Nagaya N, Miyatake K, Uematsu M, Oya H, Shimizu W, Hosoda H, Kojima M, Nakanishi N, Mori H, Kangawa K.
J Clin Endocrinol Metab, 86(12), 5854-5859, 2001年

Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure.
Nagaya N, Uematsu M, Kojima M, Ikeda Y, Yoshihara F, Shimizu W, Hosoda H, Hirota Y, Ishida H, Mori H, Kangawa K.
Circulation, 104(12), 1430-1435, 2001年

Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor.
Hosoda H, Kojima M, Matsuo H, Kangawa K.
J Biol Chem, 275(29), 21995-2000, 2000年

Ghrelin stimulates gastric acid secretion and motility in rats.
Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z, Hosoda H, Kojima M, Kangawa K.
Biochem Biophys Res Commun, 276(3), 905-908, 2000年

Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.
Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M.
Endocrinology, 141(11), 4255-4261, 2000年

Kidney produces a novel acylated peptide, ghrelin.
Mori K, Yoshimoto A, Takaya K, Hosoda K, Ariyasu H, Yahata K, Mukoyama M, Sugawara A, Hosoda H, Kojima M, Kangawa K, Nakao K.
FEBS Lett, 486(3), 213-216, 2000年

Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue.
Hosoda H, Kojima M, Matsuo H, Kangawa K.
Biochem Biophys Res Commun, 279(3), 909-913, 2000年

Ghrelin is a growth-hormone-releasing acylated peptide from stomach.
Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K.
Nature, 402(6762), 656-660, 1999年

Ghrelin measurement: present and perspectives.
GhigoE, Benso A, Brogli F., 分担執筆
Springer, 225-236 2004年

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1993年