冨田 拓郎 (トミタ タクロウ)
学術研究院（医学系）
医学部 医学科 分子薬理学
准教授
研究者情報
研究活動情報
受賞
論文
- A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery.
Takashi Murayama; Nagomi Kurebayashi; Takuro Numaga-Tomita; Takuya Kobayashi; Satoru Okazaki; Kyosuke Yamashiro; Tsutomu Nakada; Shuichi Mori; Ryosuke Ishida; Hiroyuki Kagechika; Mitsuhiko Yamada; Takashi Sakurai
The Journal of general physiology, 154(12), 2022年12月
- Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors.
Sayaka Oda; Kazuhiro Nishiyama; Yuka Furumoto; Yohei Yamaguchi; Akiyuki Nishimura; Xiaokang Tang; Yuri Kato; Takuro Numaga-Tomita; Toshiyuki Kaneko; Supachoke Mangmool; Takuya Kuroda; Reishin Okubo; Makoto Sanbo; Masumi Hirabayashi; Yoji Sato; Yasuaki Nakagawa; Koichiro Kuwahara; Ryu Nagata; Gentaro Iribe; Yasuo Mori; Motohiro Nishida
Nature communications, 13(1), 6374-6374, 2022年10月 - Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post-ischaemic blood flow recovery.
Takuro Numaga-Tomita; Tsukasa Shimauchi; Yuri Kato; Kazuhiro Nishiyama; Akiyuki Nishimura; Kosuke Sakata; Hiroyuki Inada; Satomi Kita; Takahiro Iwamoto; Junichi Nabekura; Lutz Birnbaumer; Yasuo Mori; Motohiro Nishida
British journal of pharmacology, 180(1), 94-110, 2022年09月 - A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.
Tsukasa Shimauchi; Takuro Numaga-Tomita; Yuri Kato; Hiroyuki Morimoto; Kosuke Sakata; Ryosuke Matsukane; Akiyuki Nishimura; Kazuhiro Nishiyama; Atsushi Shibuta; Yutoku Horiuchi; Hitoshi Kurose; Sang Geon Kim; Yasuteru Urano; Takashi Ohshima; Motohiro Nishida
Cells, 11(13), 2022年06月 - Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart
Hiroyuki Kawagishi; Tsutomu Nakada; Takuro Numaga-Tomita; Maite Larrañaga; Ang Guo; Long-Sheng Song; Mitsuhiko Yamada
American Journal of Physiology-Heart and Circulatory Physiology, 2022年05月, 査読有り, 招待無し - NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis.
Hideaki Inazumi; Koichiro Kuwahara; Yasuaki Nakagawa; Yoshihiro Kuwabara; Takuro Numaga-Tomita; Toshihide Kashihara; Tsutomu Nakada; Nagomi Kurebayashi; Miku Oya; Miki Nonaka; Masami Sugihara; Hideyuki Kinoshita; Kenji Moriuchi; Hiromu Yanagisawa; Toshio Nishikimi; Hirohiko Motoki; Mitsuhiko Yamada; Sachio Morimoto; Kinya Otsu; Richard M Mortensen; Kazuwa Nakao; Takeshi Kimura
Circulation research, 130(2), 234-248, 2021年12月 - Gravity sensing in plant and animal cells
Ken Takahashi; Hideyuki Takahashi; Takuya Furuichi; Masatsugu Toyota; Makoto Furutani-Seiki; Takeshi Kobayashi; Haruko Watanabe-Takano; Masahiro Shinohara; Takuro Numaga-Tomita; Asako Sakaue-Sawano; Atsushi Miyawaki; Keiji Naruse
npj Microgravity, 7(1), 2021年12月 - β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate.
Toshihide Kashihara; Hiroyuki Kawagishi; Tsutomu Nakada; Takuro Numaga-Tomita; Shin Kadota; Elena E Wolf; Cheng-Kun Du; Yuji Shiba; Sachio Morimoto; Mitsuhiko Yamada
JACC. Basic to translational science, 5(11), 1057-1069, 2020年11月 - TRPC Channels in Cardiac Plasticity
Numaga-Tomita T, Nishida M.
., 9, 454, 2020年02月 - TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN.
Numaga-Tomita T; Shimauchi T; Oda S; Tanaka T; Nishiyama K; Nishimura A; Birnbaumer L; Mori Y; Nishida M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(9), 9785-9796, 2019年09月, 査読有り, 招待無し - Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3-Nox2 protein complex.
Nishiyama K; Numaga-Tomita T; Fujimoto Y; Tanaka T; Toyama C; Nishimura A; Yamashita T; Matsunaga N; Koyanagi S; Azuma YT; Ibuki Y; Uchida K; Ohdo S; Nishida M
British journal of pharmacology, 176(18), 3723-3738, 2019年09月, 査読有り, 招待無し - TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy.
Sudi SB; Tanaka T; Oda S; Nishiyama K; Nishimura A; Sunggip C; Mangmool S; Numaga-Tomita T; Nishida M
Scientific reports, 9(1), 9785-9785, 2019年07月, 査読有り, 招待無し - Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload.
Nishimura A; Shimoda K; Tanaka T; Toyama T; Nishiyama K; Shinkai Y; Numaga-Tomita T; Yamazaki D; Kanda Y; Akaike T; Kumagai Y; Nishida M
Science signaling, 12(587), 2019年06月, 査読有り, 招待無し - TRPC channels in exercise-mimetic therapy.
Takuro Numaga-Tomita; Sayaka Oda; Kazuhiro Nishiyama; Tomohiro Tanaka; Akiyuki Nishimura; Motohiro Nishida
Pflugers Archiv : European journal of physiology, 471(3), 507-517, 2019年03月, 査読有り, 招待無し - Mitochondrial dynamics in exercise physiology.
Tanaka T; Nishimura A; Nishiyama K; Goto T; Numaga-Tomita T; Nishida M
Pflugers Archiv : European journal of physiology, 2019年02月, 査読有り, 招待無し - Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.
Nishimura A; Shimauchi T; Tanaka T; Shimoda K; Toyama T; Kitajima N; Ishikawa T; Shindo N; Numaga-Tomita T; Yasuda S; Sato Y; Kuwahara K; Kumagai Y; Akaike T; Ide T; Ojida A; Mori Y; Nishida M
Science Signaling, 11(556), eaat5185, 2018年11月, 査読有り, 招待無し
- TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice.
Oda S, Numaga-Tomita T, Kitajima N, Toyama T, Harada E, Shimauchi T, Nishimura A, Ishikawa T, Kumagai Y, Birnbaumer L, Nishida M.
Sci Rep, 7, 7511, 2018年08月 - TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes
Yohei Yamaguchi; Gentaro Iribe; Toshiyuki Kaneko; Ken Takahashi; Takuro Numaga-Tomita; Motohiro Nishida; Lutz Birnbaumer; Keiji Naruse
Journal of Physiological Sciences, 68(2), 153-164, 2018年03月, 査読有り, 招待無し - TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy.
Caroline Sunggip; Kakeru Shimoda; Sayaka Oda; Tomohiro Tanaka; Kazuhiro Nishiyama; Supachoke Mangmool; Akiyuki Nishimura; Takuro Numaga-Tomita; Motohiro Nishida
Frontiers in pharmacology, 9, 523-523, 2018年, 査読有り, 招待無し - [New Strategies for Exercise-Mimetic Medication].
Oda S; Numaga-Tomita T; Nishida M
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 138(10), 1257-1262, 2018年, 査読有り, 招待無し - Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases
Akiyuki Nishimura; Caroline Sunggip; Sayaka Oda; Takuro Numaga-Tomita; Makoto Tsuda; Motohiro Nishida
PHARMACOLOGY & THERAPEUTICS, 180, 113-128, 2017年12月, 査読有り, 招待無し - TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.
Shimauchi T; Numaga-Tomita T; Ito T; Nishimura A; Matsukane R; Oda S; Hoka S; Ide T; Koitabashi N; Uchida K; Sumimoto H; Mori Y; Nishida M
JCI insight, 2(15), 2017年08月, 査読有り, 招待無し - TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice
Sayaka Oda; Takuro Numaga-Tomita; Naoyuki Kitajima; Takashi Toyama; Eri Harada; Tsukasa Shimauchi; Akiyuki Nishimura; Tatsuya Ishikawa; Yoshito Kumagai; Lutz Birnbaumer; Motohiro Nishida
SCIENTIFIC REPORTS, 7(1), 7511, 2017年08月, 査読有り, 招待無し - The functions of store-operated calcium channels
James W. Putney; Natacha Steinckwich-Besancon; Takuro Numaga-Tomita; Felicity M. Davis; Pooja N. Desai; Diane M. D'Agostin; Shilan Wu; Gary S. Bird
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1864(6), 900-906, 2017年06月, 査読有り, 招待無し - Purinergic P2Y(6) receptors: A new therapeutic target of age-dependent hypertension
Caroline Sunggip; Akiyuki Nishimura; Kakeru Shimoda; Takuro Numaga-Tomita; Makoto Tsuda; Motohiro Nishida
PHARMACOLOGICAL RESEARCH, 120, 51-59, 2017年06月, 査読有り, 招待無し - TRPC3 Channels in Cardiac Fibrosis.
Numaga-Tomita T; Oda S; Shimauchi T; Nishimura A; Mangmool S; Nishida M
Frontiers in cardiovascular medicine, 4, 56, 2017年, 査読有り, 招待無し - TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis
Takuro Numaga-Tomita; Naoyuki Kitajima; Takuya Kuroda; Akiyuki Nishimura; Kei Miyano; Satoshi Yasuda; Koichiro Kuwahara; Yoji Sato; Tomomi Ide; Lutz Birnbaumer; Hideki Sumimoto; Yasuo Mori; Motohiro Nishida
SCIENTIFIC REPORTS, 6, 39383, 2016年12月, 査読有り, 招待無し - TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling
Naoyuki Kitajima; Takuro Numaga-Tomita; Masahiko Watanabe; Takuya Kuroda; Akiyuki Nishimura; Kei Miyano; Satoshi Yasuda; Koichiro Kuwahara; Yoji Sato; Tomomi Ide; Lutz Birnbaumer; Hideki Sumimoto; Yasuo Mori; Motohiro Nishida
SCIENTIFIC REPORTS, 6, 37001, 2016年11月, 査読有り, 招待無し - TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation
Takuro Numaga-Tomita; Motohiro Nishida; James W. Putney; Yasuo Mori
BIOCHEMICAL JOURNAL, 473(2), 201-210, 2016年01月, 査読有り, 招待無し - Purinergic P2Y(6) receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension
Akiyuki Nishimura; Caroline Sunggip; Hidetoshi Tozaki-Saitoh; Tsukasa Shimauchi; Takuro Numaga-Tomita; Katsuya Hirano; Tomomi Ide; Jean-Marie Boeynaems; Hitoshi Kurose; Makoto Tsuda; Bernard Robaye; Kazuhide Inoue; Motohiro Nishida
SCIENCE SIGNALING, 9(411), ra7, 2016年01月, 査読有り, 招待無し - Establishment of a Novel Therapeutic Strategy for Heart Failure Based on the Mechanism Underlying Maintenance of Redox Homeostasis by Reactive Sulfur Species
Motohiro Nishida; Takashi Toyama; Yoshito Kumagai; Takuro Numaga-Tomita
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 134(12), 1239-1243, 2014年12月, 査読有り, 招待無し - Role of STIM1-and Orai1-mediated Ca2+ entry in Ca2+-induced epidermal keratinocyte differentiation
Takuro Numaga-Tomita; James W. Putney
JOURNAL OF CELL SCIENCE, 126(2), 605-612, 2013年01月, 査読有り, 招待無し - Deletion of Orai1 alters expression of multiple genes during osteoclast and osteoblast maturation
Sung-Yong Hwang; Julie Foley; Takuro Numaga-Tomita; John G. Petranka; Gary S. Bird; James W. Putney
CELL CALCIUM, 52(6), 488-500, 2012年12月, 査読有り, 招待無し - Alternative translation initiation gives rise to two isoforms of Orai1 with distinct plasma membrane mobilities
Miwako Fukushima; Takuro Tomita; Agnes Janoshazi; James W. Putney
JOURNAL OF CELL SCIENCE, 125(18), 4354-4361, 2012年09月, 査読有り, 招待無し - Direct Observation of Protein Microcrystals in Crystallization Buffer by Atmospheric Scanning Electron Microscopy
Yuusuke Maruyama; Tatsuhiko Ebihara; Hidetoshi Nishiyama; Yuji Konyuba; Miki Senda; Takuro Numaga-Tomita; Toshiya Senda; Mitsuo Suga; Chikara Sato
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 13(8), 10553-10567, 2012年08月, 査読有り, 招待無し - Phospholipase C signaling and calcium influx.
Putney JW; Tomita T
Advances in biological regulation, 52(1), 152-164, 2012年01月, 査読有り, 招待無し - Activation and regulation of store-operated calcium entry
Jeremy T. Smyth; Sung-Yong Hwang; Takuro Tomita; Wayne I. DeHaven; Jason C. Mercer; James W. Putney
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 14(10), 2337-2349, 2010年10月, 査読有り, 招待無し - Ca2+ influx and protein scaffolding via TRPC3 sustain PKC beta and ERK activation in B cells
Takuro Numaga; Motohiro Nishida; Shigeki Kiyonaka; Kenta Kato; Masahiro Katano; Emiko Mori; Tomohiro Kurosaki; Ryuji Inoue; Masaki Hikida; James W. Putney; Yasuo Mori
JOURNAL OF CELL SCIENCE, 123(6), 927-938, 2010年03月, 査読有り, 招待無し - Store operated calcium entry in NIH-3T3 cells.
Tomita T; Bird GS; Putney JW
Journal of Medical Investigation, 56, 381-382, 2009年12月, 招待無し - A Pathogenic C Terminus-truncated Polycystin-2 Mutant Enhances Receptor-activated Ca2+ Entry via Association with TRPC3 and TRPC7
Kyoko Miyagi; Shigeki Kiyonaka; Kazunori Yamada; Takafumi Miki; Emiko Mori; Kenta Kato; Tomohiro Numata; Yuichi Sawaguchi; Takuro Numaga; Toru Kimura; Yoshikatsu Kanai; Mitsuhiro Kawano; Minoru Wakamori; Hideki Nomura; Ichiro Koni; Masakazu Yamagishi; Yasuo Mori
JOURNAL OF BIOLOGICAL CHEMISTRY, 284(49), 34400-34412, 2009年12月, 査読有り, 招待無し - TRPC channels function independently of STIM1 and Orai1
Wayne I. DeHaven; Bertina F. Jones; John G. Petranka; Jeremy T. Smyth; Takuro Tomita; Gary S. Bird; James W. Putney
JOURNAL OF PHYSIOLOGY-LONDON, 587(10), 2275-2298, 2009年05月, 査読有り, 招待無し - Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound
Shigeki Kiyonaka; Kenta Kato; Motohiro Nishida; Kazuhiro Mio; Takuro Numaga; Yuichi Sawaguchi; Takashi Yoshida; Minoru Wakamori; Emiko Mori; Tomohiro Numata; Masakazu Ishii; Hiroki Takemoto; Akio Ojida; Kenta Watanabe; Aya Uemura; Hitoshi Kurose; Takashi Morii; Tsutomu Kobayashi; Yoji Sato; Chikara Sato; Itaru Hamachi; Yasuo Mori
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(13), 5400-5405, 2009年03月, 査読有り, 招待無し - Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum
Yoshihiro Baba; Kenji Hayashit; Yoko Fujii; Akiko Mizushima; Hiroshi Watarai; Minoru Wakamori; Takuro Numaga; Yasuo Mori; Masamitsu Iino; Masaki Hikida; Tomohiro Kurosaki
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(45), 16704-16709, 2006年11月, 査読有り, 招待無し - The role of canonical transient receptor potential 7 in B-cell receptor-activated channels
JP Lievremont; T Numaga; G Vazquez; L Lemonnier; Y Hara; E Mori; M Trebak; SE Moss; GS Bird; Y Mori; JW Putney
JOURNAL OF BIOLOGICAL CHEMISTRY, 280(42), 35346-35351, 2005年10月, 査読有り, 招待無し - Arabidopsis TOBAMOVIRUS MULTIPLICATION (TOM) 2 locus encodes a transmembrane protein that interacts with TOM1
Y Tsujimoto; T Numaga; K Ohshima; M Yano; R Ohsawa; DB Goto; S Niato; M Ishikawa
EMBO JOURNAL, 22(2), 335-343, 2003年01月, 査読有り, 招待無し - Activation and regulation of store-operated calcium entry
Jeremy T. Smyth; Sung-Yong Hwang; Takuro Tomita; Wayne I. DeHaven; Jason C. Mercer; James W. Putney
MISC
講演・口頭発表等
- 交感神経除神経が新生児・乳児の心臓発達に与える影響の解析
Takuro Numaga-Tomita; Hiroyuki Kawagshi; Tsutomu Nakada; Mitsuhiko Yamada
第100回日本生理学会大会, 2023年03月 - CaV1.2のC末端チロシンリン酸化の動脈硬化における重要性の解明
冨田(沼賀) 拓郎
第96回日本薬理学会年会, 2022年12月, 招待無し - 心室アクションポテンシャルに惹起されるCaV1.2電流の制御機構
Takuro Numaga-Tomita
第99回日本生理学会大会, 2022年03月, 招待無し - 交感神経除神経が新生児・乳児の心臓発達に与える影響の解析
冨田(沼賀)拓郎
第31回日本循環薬理学会, 2021年12月, 招待無し, - 交感神経除神経が新生児・乳児の心臓発達に与える影響の解析
冨田(沼賀) 拓郎
第94回日本薬理学会年会, 2021年03月, 招待無し - 血管平滑筋細胞におけるL型電位依存性カルシウムチャネルとストア作動性カルシウムチャネルの 関係性解明
冨田(沼賀) 拓郎
第30回日本循環薬理学会, 2020年11月, 招待無し - 血管平滑筋の表現型スイッチにおけるTRPC6チャネルの重要性の解明
冨田(沼賀) 拓郎
第29回日本循環薬理学会, 2019年11月, 招待無し, - Importance of TRPC3-Nox2 Coupling in Cardiac Stiffness
Takuro Numaga-Tomita
8th International Workshop Cardiac Mechano-Electric Coupling and Arrhythmias, 2019年09月, 招待有り - 病的心臓リモデリングにおけるTRPC3-Nox2の 機能連関の重要性の解明
冨田拓郎
第95回日本生理学会大会, 2018年03月, 招待無し - 筋組織恒常性維持を目指したTRPC-Nox機能連関を標的とする創薬研究
冨田拓郎
日本薬学会第138年会, 2018年03月, 招待有り - Ca2+ signaling:Positive regulation of Nox2 by TRPC3 channel mediates mechanical stress-induced cardiac fibrosis
冨田拓郎
KSC symposium 2017, 2017年04月, 招待有り - Functional and physical coupling between TRPC3 and Nox2 underlies maladaptive cardiac fibrosis.
Takuro Numata-Tomita
第94回日本生理学会大会, 2017年03月, 招待無し - Improvement of peripheral circulation after hindlimb ischemia by TRPC channel inhibition.
Takuro Numata-Tomita
第90回日本薬理学会年会, 2017年03月, 招待無し
共同研究・競争的資金等の研究課題
- 動脈硬化におけるCaV1.2のC末端リン酸化の重要性解明と創薬展開
鈴木健三記念医科学応用研究財団
2022年12月 - 2023年12月 - CaV1.2のY1709リン酸化の動脈硬化における重要性解明
アイバワークス医学研究者支援事業
2022年09月 - 2023年03月 - 出生後心臓の冠血管・交感神経ネットワーク形成の原理と心臓発達における重要性の解明
科学研究費補助金, 日本学術振興会, 基盤研究(C)
2022年04月01日 - 2025年03月31日 - 発達期心臓におけるNGF産生機構と交感神経支配の時空間的相関解析
金原一郎記念医学医療振興財団
2020年09月 - 2021年09月 - 成体における新生血管の成熟を決定する分子機構の解明と創薬応用
科学研究費補助金, 日本学術振興会, 基盤研究(C)
2019年04月 - 2022年03月 - 骨格筋および末梢循環における力学的負荷の重要性の解明
科学研究費補助金, 文部科学省, 新学術領域研究(研究領域提案型)
2018年04月 - 2020年03月 - 継続的運動負荷に対する心臓の順応とその維持による心保護効果獲得機構の解明
科学研究費補助金, 文部科学省, 若手研究(B)
2017年04月 - 2019年03月 - 宇宙生活での健康リスク低減を目指した運動による生体恒常性の頑健性獲得機構の解明
科学研究費補助金, 文部科学省, 新学術領域研究(研究領域提案型)
2016年04月 - 2018年03月 - 多次元共培養系構築を通した細胞外微小環境ダイナミクスの血管再構築への寄与の解明
科学研究費補助金, 文部科学省, 挑戦的萌芽研究
2014年 - 2015年 - 皮膚表皮カルシウムホメオスタシスの創傷治癒における生理的意義の解明
科学研究費補助金, 文部科学省, 研究活動スタート支援
2013年 - 2014年 - 循環器組織におけるL型カルシウムチャネルの新規制御機構の探索とその生理的意義の解明
