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瀧 伸介  タキ シンスケ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 免疫制御学FAX番号
職名教授メールアドレス
住所〒390-8621 松本市旭3-1-1ホームページURL

更新日:2021/07/19

プロフィール

研究分野
免疫学
現在の研究課題
好塩基球におけるIL-4産生シグナルの伝達機構
キーワード:サイトカインシグナル伝達 , 好塩基球 , IL-4 , IL-3受容体
自然免疫系細胞、特に樹状細胞やNK細胞分化発生の分子機構
キーワード:自然免疫 , 自然リンパ球 , 樹状細胞 , 粘膜免疫
炎症性皮膚疾患の発症機構とその遺伝子制御

所属学会
所属学会
日本免疫学会

所属学会役職担当
2001- , 日本免疫学会 , 評議員
2008-2018 , 日本免疫学会 , 理事
2008-2012 , 日本免疫学会 , 財務委員長
学歴
出身大学院
1983 , 大阪大学 , 理学研究科 , 生理学専攻

出身学校・専攻等(大学院を除く)
1981 , 大阪大学 , 理学部 , 生物学科

取得学位
博士(医学) , 大阪大学
研究職歴等
研究職歴
2012- , 信州大学医学部・教授
2002- , 信州大学大学院医学系研究科・教授
2000-2002 , 千葉大学大学院医学研究院・助教授
1995-2000 , 東京大学医学部・講師
1994-1994 , 東京大学医学部・助手

研究職歴以外の職歴
1983-1994 , 味の素(株)中央研究所・研究員

留学歴
1990-1993 , ケルン大学遺伝学研究所

研究活動業績

研究業績(著書・
発表論文等)
論文
Generation of a common innate lymphoid cell progenitor requires interferon regulatory factor 2
INTERNATIONAL IMMUNOLOGY,31(8):489-498 2019(Aug.)
Author:Okubo, Yohei; Tokumaru, Shigeo; Yamamoto, Yuta; Miyagawa, Shin-ichi; Sanjo, Hideki; Taki, Shinsuke;


Water intake increases mesenteric lymph flow and the total flux of albumin, long-chain fatty acids, and IL-22 in rats: new concept of absorption in jejunum.
Am J Physiol Gastrointest Liver Physiol,316:G155-G165 2019(Jan. 01)
Author:Nagashio S, Ajima K, Maejima D, Sanjo H, Kajihara R, Hayashi M, Watanabe-Asaka T, Kaidoh M, Yokoyama Y, Taki S, Kawai Y, Ohhashi T


Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death
JOURNAL OF IMMUNOLOGY,203(4):783-788 2019
Author:Sanjo, Hideki; Nakayama, Jun; Yoshizawa, Takahiro; Fehling, Hans Joerg; Akira, Shizuo; Taki, Shinsuke;


Staphylococcal alpha-hemolysin does not induce cell damage in murine mast cells but it augments the degranulation induced by Fc epsilon RI cross-linking and ionomycin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,508(1):263-269 2019
Author:Hayashi, Kazuhito; Itoh, Saotomo; Morikawa, Arisa; Onozaki, Kikuo; Taki, Shinsuke; Tsuji, Tsutomu; Hida, Shigeaki;


Staphylococcal superantigen-like 12 activates murine bone marrow derived mast cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,511(2):350-355 2019
Author:Kobayashi, Masato; Kitano, Takuma; Nishiyama, Saishi; Sanjo, Hideki; Onozaki, Kikuo; Taki, Shinsuke; Itoh, Saotomo; Hida, Shigeaki;


転写因子IRF-2の自然リンパ球分化への関与
臨床免疫・アレルギー科,72(5):480-485 2019
Author:瀧伸介


Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCR alpha beta(+) Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis
PLOS ONE,10(7) 2015
Author:Sanjo, Hideki; Tokumaru, Shigeo; Akira, Shizuo; Taki, Shinsuke;


IL-15とNK細胞の発生・分化・ホメオスタシス
臨床免疫・アレルギー科,59:140-146 2013
Author:瀧 伸介


IRF-2 regulates B-cell proliferation and antibody production through distinct mechanisms
INTERNATIONAL IMMUNOLOGY,24(9):573-581 2012(Sep.)
Author:Minamino, Kento; Takahara, Kazuhiko; Adachi, Takumi; Nagaoka, Koji; Iyoda, Tomonori; Taki, Shinsuke; Inaba, Kayo;


Differential Requirements for IRF-2 in Generation of CD1d-Independent T Cells Bearing NK Cell Receptors
JOURNAL OF IMMUNOLOGY,188(10):4838-4845 2012
Author:Notake, Tsuyoshi; Horisawa, Shin; Sanjo, Hideki; Miyagawa, Shin-ichi; Hida, Shigeaki; Taki, Shinsuke;


Critical role of Th17 cells in inflammation and neovascularization after ischaemia
CARDIOVASCULAR RESEARCH,90(2):364-372 2011(May)
Author:Hata, Takeki; Takahashi, Masafumi; Hida, Shigeaki; Kawaguchi, Masanori; Kashima, Yuichiro; Usui, Fumitake; Morimoto, Hajime; Nishiyama, Akiyo; Izawa, Atsushi; Koyama, Jun; Iwakura, Yoichiro; Taki, Shinsuke; Ikeda, Uichi;


IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice
JOURNAL OF IMMUNOLOGY,187(10):5162-5169 2011
Author:Yoshizawa, Katsumi; Nakajima, Shinsuke; Notake, Tsuyoshi; Miyagawa, Shin-Ichi; Hida, Shigeaki; Taki, Shinsuke;


活性化T細胞におけるNKレセプターの発現
臨床免疫・アレルギー科,55:475-482 2011
Author:野竹剛、瀧 伸介


Potentiation of TLR9 responses for human naive B-cell growth through RP105 signaling
CLINICAL IMMUNOLOGY,135(1):125-136 2010(Apr.)
Author:Yamazaki, Kazuko; Yamazaki, Takashi; Taki, Shinsuke; Miyake, Kensuke; Hayashi, Takuma; Ochs, Hans D.; Agematsu, Kazunaga;


好塩基球におけるIL-4産生誘導シグナル伝達機構とTh2分化
臨床免疫・アレルギー科,54:546-553 2010
Author:小田朗永、瀧伸介


好塩基球からのIL-4産生誘導機序
炎症と免疫,18:9-13 2010
Author:肥田重明、瀧 伸介


Th2分化と好塩基球
実験医学,28:1879-1884 2010
Author:肥田重明、瀧 伸介


STAT6 signalling is important in CD8(+) T-cell activation and defence against Toxoplasma gondii infection in the brain
IMMUNOLOGY,127(2):187-195 2009(Jun.)
Author:Jin, Donghao; Takamoto, Masaya; Hu, Tao; Taki, Shinsuke; Sugane, Kazuo;


Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils
NATURE IMMUNOLOGY,10(2):214-222 2009(Feb.)
Author:Hida, Shigeaki; Yamasaki, Sho; Sakamoto, Yuzuru; Takamoto, Masaya; Obata, Kazushige; Takai, Toshiyuki; Karasuyama, Hajime; Sugane, Kazuo; Saito, Takashi; Taki, Shinsuke;


Distinct response in maintenance of human naive and memory B cells via IL-21 receptor and TCL1/Akt pathways
CELLULAR IMMUNOLOGY,256(1-2):56-63 2009
Author:Nagumo, Haruo; Abe, Jun; Kano, Hirotsugu; Taki, Shinsuke; Yamazaki, Kazuko; Yamazaki, Takashi; Kobayashi, Norimoto; Koike, Kenichi; Sugane, Kazuo; Saito, Hirohisa; Agematsu, Kazunaga;


Contribution of Th17 Cells, a New Subset of CD4(+) T Cells, to Angiogenic Response to Hindlimb Ischemia
CIRCULATION,120(18):S1052-S1052 2009
Author:Hata, Takeki; Takahashi, Masafumi; Kawaguchi, Masanori; Kashima, Yu-ichiro; Izawa, Atsushi; Hida, Shigeaki; Iwakura, Yo-ichiro; Taki, Shinsuke; Ikeda, U-ichi;


IL-3レセプターシグナルによる好塩基球のサイトカイン産生制御の解明
医学のあゆみ,230(4):303 2009
Author:肥田重明、瀧 伸介


好塩基球のIL-4産生における細胞内シグナル伝達
実験医学,27:3271-3278 2009
Author:瀧 伸介


Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling
EXPERIMENTAL HEMATOLOGY,36(3):255-264 2008
Author:Mizutani, Tatsuaki; Tsuji, Kohichiro; Ebihara, Yasuhiro; Taki, Shinsuke; Ohba, Yusuke; Taniguchi, Tadatsugu; Honda, Kenya;


IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1(+)B220(+) NK cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,369(4):1139-1143 2008
Author:Nakajima, S; Hida, S; Taki, S


Genetic control directed toward spontaneous IFN-alpha/IFN-beta responses and downstream IFN-gamma expression influences the pathogenesis of a murine psoriasis-like skin disease
JOURNAL OF IMMUNOLOGY,179(5):3249-3257 2007
Author:Arakura, Fuyuko; Hida, Shigeaki; Ichikawa, Eri; Yajima, Chihiro; Nakajima, Shinsuke; Saida, Toshiaki; Taki, Shinsuke;


Inhibitory NK receptor Ly49Q is expressed on subsets of dendritic cells in a cellular maturation- and cytokine stimulation-dependent manner
J Immunol,174(8):4621-4629 2005
Author:Toyama-Sorimachi, N; Omatsu, Y; Onoda, A; Tsujimura, Y; Iyoda, T; Kikuchi-Maki, A; Sorimachi, H; Dohi, T; Taki, S; Inaba, K; Karasuyama, H


Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance
Blood,106(6):2011-2017 2005
Author:Hida S, Tadachi M, Saito T, Taki S


IFN regulatory factor-2 deficiencyrevealed a novel checkpoint critical for the generation of peripheral NK cells
J Immunol,174(10):6005-6012 2005
Author:Taki S, Nakajima S, Ichikawa E, Saito T, Hida S


IRFファミリー転写因子による免疫系の制御
信州医学雑誌,52(3):163-170 2004(Jun.)
Author:瀧 伸介
Keywords:natural immunity, dendritic cells, NK cells, gene expression, interferon, 自然免疫, 樹状細胞, NK 細胞, 遺伝子発現, インターフェロン


Defective development of splenic and epidermal CD4(+) dendritic cells in mice deficient for IFN regulatory factor-2
Proc Natl Acad Sci USA,101(11):3909-3914 2004
Author:Ichikawa E, Hida S, Omatsu Y, Shimoyama S, Takahara K, Miyagawa S, Inaba K, Taki S


Overexpression of human acyl CoA thioesterase upregulates peroxisome biogenesis
Exp Cell Res,297:127-141 2004
Author:Ishizuka M, Toyama Y, Watanabe H, Fujiki Y, Takeuchi A, Yamasaki S, Yuasa S, Miyazaki M, Nakajima N, Taki S, Saito T


Prostaglandin D-2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine
J Exp Med,198(4):533-543 2003
Author:Honda, K; Arima, M; Cheng, G; Taki, S; Hirata, H; Eda, F; Fukushima, F; Yamaguchi, B; Hatano, M; Tokuhisa, T; Fukuda, T


Predominant role of T cell receptor (TCR)-alpha chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system
J Exp Med,195:991-1001 2002
Author:Yokosuka T, Takase K, Suzuki M, Nakagawa Y, Taki S, Takahashi H, Fujisawa T, Arase H, Saito T


Type I interferons and autoimmunity: lessons from the clinic and from IRF-2-deficient mice
Cytokine Growth Factor Rev,13(4-5):379-391 2002
Author:Taki S


C1q regulatory region polymorphism down-regulating murine C1q protein levels with linkage to lupus nephritis
J Immunol,169(3):1334-1339 2002
Author:Miura-Shimura Y, Nakamura K, Ohtsuji M, Tomita H, JiangY, Abe M, Zhang D, Hamano Y, Tsuda H, Hashimoto H, Nishimura H, Taki S, Shirai T, Hirose S


Role for Bcl-6in generation and maintenance of memory CD8+ T cells
Nat Immunol,3:558-563 2002
Author:Ichii H, Sakamoto A, Hatano M, Okada S, Toyama H, Taki S, Arima M, Kuroda Y, Tokuhisa T


CD8+ T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-a/b signaling.
Immunity,13:643-655 2000
Author:Hida, S., Ogasawara, K., Sato, K., Takayanagi, H., Yokochi, T., Sato, T., Hirose, S.,Shirai, T., Taki, S., Taniguchi, T.


Functional dissection of the cytoplasmic subregions of the IL-2 receptor bc chain in primary lymphocyte population.
EMBO J.,17:6551-6557 1998
Author:Fujii, H., Ogasawara, K., Otsuka, H., Suzuki, M., Yamamura, K.-I., Yokochi, T., Miyazaki, T., Suzuki, H., Mak, T.W., Taki, S., Taniguchi, T.


Requirement for IRF-1 in the microenvironment supporting development of natural killer cells.
Nature,391:700-703 1998
Author:Ogasawara, K., Hida, S., Azimi, N., Tagaya, Y., Sato, T., Yokochi-Fukuda, T.,Waldmann, T.A., Taniguchi, T., Taki, S.


The Iga/Igb heterodimer on m-negative proB cells is component for transducing signals to induce early B cell differentiation
Immunity,7:559-570 1997
Author:Nagata, K., Nakamura, T., Kitamura, F., Kuramochi, S., Taki, S., Campbell, K.S. and Karasuyama, H.


Multi-stage regulation of Th1-type immune responses by the transcriptionfactor IRF-1
Immunity,6:673-679 1997
Author:Taki, S., Sato, T., Ogasawara, K., Fukuda, T., Sato, M., Hida, H., Suzuki, G., Mitsuyama, M., Shin, E.-H., Kojima, K., Taniguchi, T., Asano, Y.


B cell development under the condition of allelic inclusion.
Immunity,6:225-233 1997
Author:Sonoda, E., Pewzner-Jung, Y., Schwers, S., Taki, S., Jung, S., Eilat, D., Rajewsky, K.


An IRF-1 dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes.
Nature,376:596-599 1995
Author:Tamura, T., Ishihara, M., Lamphier, M.S., Tanaka, N., Oishi, I., Aizawa, S., T.,Mak, T.W., Taki, S., Taniguchi, T.


Rearrangement of upstream DH and VH region genes into a rearranged immunoglobulin variable region gene inserted into the immunoglobulin heavychain locus.
Eur. J. Immunol.,25:1888-1896 1995
Author:Taki, S., Schwenk, F., Rajewsky, K.


Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus.
Science,262:1268-1271 1993
Author:Taki, S., Meiering, M., Rajewsky, K.


T cell-dependent antibody production by Ly-1 B cells
Ann. N.Y. Acad. Sci.,651:328-335 1992
Author:Taki, S., Shmitt, M., Tarlinton, D., Förster, I, Rajewsky, K


Somatically mutated IgG anti-DNA antibody clonally related to germ-line encoded IgM anti-DNA antibody
Eur. J. Immunol.,22:987-992 1992
Author:Taki S, Hirose S, Kinoshita K, Nishimura H, Shimamura T, Hamuro J, Shirai T


Retroviral expression of the human IL-2 gene in a murine T cell line results in cell growth autonomy and tumorigenicity.
EMBO J.,6:2705-2709 1987
Author:Yamada G, Kitamura Y, Sonoda H, Harada H, Taki S, Mulligan RC, Osawa H, Diamanstein T, Yokoyama S, Taniguchi T


Unique structure of murine interleukin-2 as deduced from cloned cDNAs
Nature,313:402-404 1985
Author:Kashima N, Nishi-Kataoka C, Fujita T, Taki S, Yamada G, Hamuro J, Taniguchi T


MISC
組織と臓器の移植
Peter Parham著 笹月健彦監訳 エッセンシャル免疫学 第2版,:447-480 2010
Author:瀧 伸介 (訳)

教育活動実績

授業等
2010 , 後期 , 免疫学演習・実習
2010 , 後期 , ユニット講義・免疫アレルギー
2009 , 後期 , 免疫学演習・実習
2009 , 後期 , ユニット講義・免疫アレルギー
2008 , 後期 , 免疫学演習・実習
2008 , 後期 , ユニット講義・免疫アレルギー
2007 , 後期 , 免疫学演習・実習
2007 , 後期 , ユニット講義・免疫アレルギー
2006 , 後期 , 免疫学演習・実習
2006 , 後期 , ユニット講義・免疫アレルギー
2005 , 後期 , 免疫学演習・実習
2004 , 前期 , 免疫学演習・実習
2004 , 後期 , 免疫学演習・実習
2003 , 前期 , 免疫学演習・実習
2003 , 後期 , 免疫学演習・実習