信州大学HOMEENGLISH交通・キャンパス案内

研究者総覧研究者総覧

研究者、研究内容などで検索
項目別検索はこちら

宮原 大貴  ミヤハラ ヒロキ

教員組織電話番号
教育組織先鋭領域融合研究群 バイオメディカル研究所 ニューロヘルスイノベーションFAX番号
職名助教(特定雇用)メールアドレス12mh207j@shinshu-u.ac.jp
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

プロフィール

研究分野
分子生物学
バイオインフォマティクス
キーワード:アミロイドーシス
現在の研究課題
アミロイドーシス発症機構の分子生物学的研究

所属学会
所属学会
国際アミロイドーシス学会
日本アミロイドーシス研究会
老化促進モデルマウス学会
学歴
出身大学院
2017 , 信州大学 , 医学
2012 , 金沢大学 , 工学

出身学校・専攻等(大学院を除く)
2010 , 金沢大学 , 工学部

取得学位
博士(医学) , 信州大学
研究職歴等
研究職歴
2018- , 信州大学医学部医学科 助教(特定雇用)

研究活動業績

研究業績(著書・
発表論文等)
論文
Glavonoid-rich oil supplementation reduces stearoyl-coenzyme A desaturase 1 expression and improves systemic metabolism in diabetic, obese KK-A mice
Biomedicine & Pharmacotherapy 2021
Author:Yuichi Igarashi, Shiho Iida, Jian Dai, Jia Huo, Xiaoran Cui, Jinko Sawashita, Masayuki Mori, Hiroki Miyahara, Keiichi Higuchi


Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway
Elife 2020
Author:Jian Dai, Ying Li, Fuyuki Kametani, Xiaoran Cui, Yuichi Igarashi, Jia Huo, Hiroki Miyahara, Masayuki Mori,Keiichi Higuchi


Suppression of Mouse AApoAII Amyloidosis Progression by Daily Supplementation with Oxidative Stress Inhibitors
Oxid Med Cell Longev,Volume 2019:1263274 2019
Author:Dai J, Ding X, Miyahara H, Xu Z, Cui X, Igarashi Y, Sawashita J, Mori M, Higuchi K


Coenzyme Q10 prevents senescence and dysfunction caused by oxidative stress in vascular endothelial cells
Oxid Med Cell Longev,:3181759 2018
Author:Huo J, Xu Z, Hosoe K, Kubo H, Miyahara H, Dai J, Mori M, Sawashita J, Higuchi K


Amyloidosis-inducing activity of blood cells in mouse AApoAII amyloidosis
Exp Anim,67((2)):105-115 2018
Author:Ding X, Liu Y, Yang M, Li L, Miyahara H, Dai J, Xu Z, Matsumoto, Mori M, Higuchi k, Sawashita J


Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure
Sci Rep,(8):5620 2018
Author:Yang M, Liu Y, Dai J, Li L, Ding X, Xu Z, Mori M, Miyahara H, Sawashita J, Higuchi K


Comprehensive proteomic profiles of mouse AApoAII amyloid fibrils provide insights into the involvement of lipoproteins in the pathology of amyloidosis
J Proteomics,(172):111-121 2018
Author:Miyahara H, Sawashita J, Ishikawa E, Yang M, Ding X, Liu Y, Hachiya N, Kametani F, Yazaki M, Mori M, Higuchi K


Apolipoprotein A-II accelerates reactive AA amyloidosis
Amyloid,24((sup1)):147-148 2017
Author:Yang M, Liu Y, Li L, Miyahara H, Ding X, Dai J, Sawashita J, Mori M, Higuchi K


Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis
PLoS ONE,12((2)):e0172402 2017
Author:Li L, Sawashita J, Ding X, Yang M, Xu Z, Miyahara H, Mori M, Higuchi K


Distribution of transmissible amyloid proteins in the liver with apolipoprotein A-II amyloidosis
Shinshu Med J,64((4)):183-194 2016
Author:Liu Y, Sawashita J, Wang Y, Li L, Miyahara H, Ding X, Yang M, Higuchi K


Factors to preserve CpG-rich sequences in methylated CpG islands
BMC Genomics,(16):144 2015
Author:Miyahara H, Hirose O, Satou K, Yamada Y


Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart
Lab Invest,95((3)):320-33 2015
Author:Luo H, Sawashita J, Tian G, Liu Y, Li L, Ding X, Xu Z, Yang M, Miyahara H, Mori M, Qian J, Wang Y, Higuchi K


講演・口頭発表等
CURCUMIN PROMOTES PROGRESSION OF AApoAII AMYLOIDOSIS IN MICE BY ACTIVATING THE PPARα SIGNALING PATHWAY
The XVII International Symposium of Amyloidosis 2020
Presenter:Dai Jian, Cui Xiaoran, Igarashi Yuichi, Li Ying, Miyahara Hiroki, Mori Masayuki, Higuchi Keiichi


A cellular model of amyloid degradation using macrophages cultured with mouse AApoAII amyloid fibrils
The XVII International Symposium of Amyloidosis 2020
Presenter:Hiroki Miyahara, Xiaoran Cui, Yuichi Igarashi, Ying Li, Jian Dai, Masayuki Mori, Keiichi Higuchi


Proteomic Analysis of Mouse AApoAII Amyloidosis
The 10th Institute for Biomedical Sciences International Symposium 2018
Presenter:Miyahara H


Comprehensive proteomic analysis of Mouse AApoAII amyloidosis
Asian Pacific Prion Symposium 2018 (APPS2018) 2018
Presenter:Miyahara H, Mori M, Higuchi K


Proteomic Profiles of Mouse AApoAII Amyloid Fibrils Provide Insights into the Involvement of Lipoproteins in the Pathology of Amyloidosis
第18回日本蛋白科学会年会 2018
Presenter:Miyahara H, Mori M, Higuchi K