中田 勉 (ナカダ ツトム)
学術研究院（総合人間科学系）
基盤研究支援センター
准教授
研究者情報
研究活動情報
論文
- Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart
Kawagishi, Hiroyuki; Nakada, Tsutomu; Numaga-Tomita, Takuro; Larranaga, Maite; Guo, Ang; Song, Long-Sheng; Yamada, Mitsuhiko;
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 323(1), H103-H120, 2022年07月
- NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis
Inazumi, Hideaki; Kuwahara, Koichiro; Nakagawa, Yasuaki; Kuwabara, Yoshihiro; Numaga-Tomita, Takuro; Kashihara, Toshihide; Nakada, Tsutomu; Kurebayashi, Nagomi; Oya, Miku; Nonaka, Miki; Sugihara, Masami; Kinoshita, Hideyuki; Moriuchi, Kenji; Yanagisawa, Hiromu; Nishikimi, Toshio; Motoki, Hirohiko; Yamada, Mitsuhiko; Morimoto, Sachio; Otsu, Kinya; Mortensen, Richard M.; Nakao, Kazuwa; Kimura, Takeshi;
Circulation Research, 130(2), 234-248, 2022年 - Adrenomedullin-RAMP2 and -RAMP3 Systems Regulate Cardiac Homeostasis during Cardiovascular Stress
Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T.
Endocrinology., 162(3), bqab001, 2021年03月 - β-Arrestin-Biased AT 1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate
Kashihara T, Kawagishi H, Nakada T, Numaga-Tomita T, Kadota S, Wolf EE, Du CK, Shiba Y, Morimoto S, Yamada M.
JACC Basic Transl Sci., 5(11), 1057-1069, 2020年11月 - Prostanoid EP4 Receptor-Mediated Augmentation of I-h Currents in A beta Dorsal Root Ganglion Neurons Underlies Neuropathic Pain
Zhang, Hao; Kashihara, Toshihide; Nakada, Tsutomu; Tanaka, Satoshi; Ishida, Kumiko; Fuseya, Satoshi; Kawagishi, Hiroyuki; Kiyosawa, Kenkichi; Kawamata, Mikito; Yamada, Mitsuhiko;
Journal of Pharmacology and Experimental Therapeutics, 368(1), 50-58, 2019年 - Increase in phospholamban content in mouse skeletal muscle after denervation
Komatsu, Masatoshi; Nakada, Tsutomu; Kawagishi, Hiroyuki; Kato, Hiroyuki; Yamada, Mitsuhiko;
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 39(5-6), 163-173, 2018年12月 - PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length Ca(V)1.2 C-terminus
Guo, Xiaoguang; Kashihara, Toshihide; Nakada, Tsutomu; Aoyama, Toshifumi; Yamada, Mitsuhiko;
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 470(6), 909-921, 2018年06月, 査読有り - Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction
Nakada, Tsutomu; Kashihara, Toshihide; Komatsu, Masatoshi; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;
Proceedings of the National Academy of Sciences of the United States of America, 115(17), 4507-4512, 2018年04月, 査読有り - Angiotensin II activates Ca(V) 1.2 Ca(2+) channels through β-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes.
Kashihara T, Nakada T, Kojima K, Takeshita T, Yamada M.
J Physiol, 595(13), 4207-4225, 2017年07月, 査読有り - Ammonia exposure affects the mRNA and protein expression levels of certain Rhesus glycoproteins in the gills of climbing perch
Chen, Xiu L.; Zhang, Biyan; Chng, You R.; Ong, Jasmine L. Y.; Chew, Shit F.; Wong, Wai P.; Lam, Siew H.; Nakada, Tsutomu; Ip, Yuen K.;
JOURNAL OF EXPERIMENTAL BIOLOGY, 220(16), 2916-2931, 2017年, 査読有り - マイクロRNAを標的とした核酸医薬による骨格筋サルコペニア予防・治療法の開発
中田勉
医科学応用研究財団研究報告, 33, 296-300, 2016年02月 - β(2)-Adrenergic and M(2)-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure
Kashihara, T; Hirose, M; Shimojo, H; Nakada, T; Gomi, S; Hongo, M; Yamada, M
European Journal of Pharmacology, 724, 122-131, 2014年02月, 査読有り
- 横紋筋L型カルシウムチャネルの結合膜局在化機構
中田勉，山田充彦
日本薬理学雑誌, 144, 217-221, 2014年 - TRPM4 channels mediate hypertonicity-induced, Ca2+-impermeable, Non-selective cation currents in a cervical cancer cell line, HeLa cells
Gomi S, Nakada T, Kashihara T, Ikeda U, Yamada M
shinshu med J, 62, 33-44, 2014年, 査読有り - Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts
Hirose M, Shibazaki T, Nakada T, Kashihara T, Yano S, Okamoto Y, Isaji M, Matsushita N, Taira E, Yamada M
Biol Pharm Bull, 37(7), 1168-1176, 2014年, 査読有り - Cardiac overexpression of constitutively active Gαq causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice
Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M
PLOS ONE, 9(8), e106354, 2014年, 査読有り - Expression of a novel isoform of Na(+)/H(+) exchanger 3 in the kidney and intestine of banded houndshark, Triakis scyllium.
Li S, Kato A, Takabe S, Chen AP, Romero MF, Umezawa T, Nakada T, Hyodo S, Hirose S
American journal of physiology. Regulatory, integrative and comparative physiology, 304(10), R865-76, 2013年05月, 査読有り - Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system.
Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T
Hypertension (Dallas, Tex. : 1979), 61(2), 341-351, 2013年02月, 査読有り - The proximal C-terminus of alpha(1C) subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels
Nakada, Tsutomu; Flucher, Bernhard E.; Kashihara, Toshihide; Sheng, Xiaona; Shibazaki, Toshihide; Horiuchi-Hirose, Miwa; Gomi, Simmon; Hirose, Masamichi; Yamada, Mitsuhiko
Biochemical Journal, 448(2), 221-231, 2012年12月, 査読有り - Two mechanistically distinct effects of dihydropyridine nifedipine on Ca(V)1.2 L-type Ca(2+) channels revealed by Timothy syndrome mutation
Xiaona Sheng, Tsutomu Nakada, Motohiro Kobayashi, Toshihide Kashihara, Toshihide Shibazaki, Miwa Horiuchi-Hirose, Simmon Gomi, Masamichi Hirose, Toshifumi Aoyama, and Mitsuhiko Yamada
Eur J Pharmacol, 685(1-3), 15-23, 2012年06月15日, 査読有り - Expression of long-form N-acetylglucosamine-6-O-sulfotransferase 1 in human high endothelial venules
Maiko Fujiwara, Motohiro Kobayashi, Hitomi Hoshino, Kenji Uchimura, Tsutomu Nakada, Junya Masumoto, Yasuhiro Sakai, Minoru Fukuda, and Jun Nakayama
J Histochem Cytochem, 60(5), 397-407, 2012年04月25日, 査読有り - Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca²⁺ channel activity through phosphatases in heart failure
Toshihide Kashihara, Tsutomu Nakada, Hisashi Shimojo, Miwa Horiuchi-Hirose, Simmon Gomi, Toshihide Shibazaki, Xiaona Sheng, Masamichi Hirose, Minoru Hongo, and Mitsuhiko Yamada
Am J Physiol Heart Circ Physiol, 302(8), H1645-1654, 2012年04月15日, 査読有り - Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice.
Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Sato F, Yamada M
PLOS ONE, 7(12), e52667, 2012年, 査読有り - Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes
Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, Ueda H, Yamada M
Am. J. Physiol. Heart Circ. Physiol., 300(3), H978–H988, 2011年03月, 査読有り - Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure: Roles of canonical transient receptor potential (TRPC) channels.
Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kubota I, Mende U, Yamada M.
Circ. J., 75(10), 2333–2342, 2011年, 査読有り - Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M
Int. J. Cardiol., 146(1), 37–43, 2011年, 査読有り - Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammonia exposure.
Nawata CM, Hirose S, Nakada T, Wood CM, Kato A.
J. Exp. Biol., 213(Pt 18), 3150-3160, 2010年09月, 査読有り - Selective α1A-adrenoceptor stimulation induces Mueller’s smooth muscle contraction in an isolated canine upper eyelid preparation.
Yano S, Hirose M, Nakada T, Nakayama J, Matsuo K, Yamada M.
Curr. Eye Res., 35(5), 363–369, 2010年05月, 査読有り - From blood typing to a transport metabolon at a crossroad. Focus on "Ammonium-dependent sodium uptake in mitochondrion-rich cells of medaka (Oryzias latipes) larvae".
Hirose S, Nakada T
American journal of physiology. Cell physiology, 298(2), C209-10, 2010年02月, 査読有り - Rhesus glycoprotein p2 (Rhp2) is a novel member of the Rh family of ammonia transporters highly expressed in shark kidney.
Nakada T, Westhoff CM, Yamaguchi Y, Hyodo S, Li X, Muro T, Kato A, Nakamura N, Hirose S
J. Biol. Chem., 285(4), 2653-2664, 2010年01月, 査読有り - Identification of renal transporters involved in sulfate excretion in marine teleost fish.
Kato A, Chang MH, Kurita Y, Nakada T, Ogoshi M, Nakazato T, Doi H, Hirose S, Romero MF.
American journal of physiology. Cell physiology, 297(6), R1647–R1659, 2009年12月, 査読有り - Diacylglycerol kinase ζ inhibits Gαq-induced atrial remodeling in transgenic mice.
Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M.
Heart Rhythm, 6(1), 78-84, 2009年01月, 査読有り - Mechanisms of preventive effect of nicorandil on ischemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular.
Hirose M, Tsujino N, Nakada T, Yano S, Imamura H, Yamada M.
Basic Clin. Pharmacol. Toxiocol., 102(6), 504-514, 2008年06月, 査読有り - Contribution of L-type Ca2+ channels to early afterdepolarizations induced by IKr and IKs channel suppression in guinea-pig ventricular myocytes.
Yamada M, Ohta K, Niwa A, Tsujino N, Nakada T, Hirose M.
J. Membr. Biol., 222(3), 151-166, 2008年04月, 査読有り - Identification of intestinal bicarbonate transporters involved in formation of carbonate precipitates to stimulate water absorption in marine teleost fish.
Kurita Y, Nakada T, Kato A, Doi H, Mistry AC, Chang MH, Romero MF, Hirose S.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 294(4), R1402-R1412, 2008年04月, 査読有り - Localization of ammonia transporter Rhcg1 in mitochondrion-rich cells of yolk sac, gill, and kidney of zebrafish and its ionic strength-dependent expression.
Nakada T, Hoshijima K, Esaki M, Nagayoshi S, Kawakami K, Hirose S.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 293, 1743-1753, 2007年10月, 査読有り - Ammonia secretion from fish gill depends on a set of Rh glycoproteins.
NakadaT, Westhoff CM, Kato A, Hirose S.
FASEB J., 21(4), 1067-1074, 2007年04月, 査読有り - Molecular and functional characterization of adrenomedullin receptors in pufferfish.
Nag K, Kato A, Nakada T, Hoshijima K, Mistry AC, Takei Y, Hirose S.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 290(2), R467-R478, 2006年02月, 査読有り - Takifugu obscurus is a euryhaline fugu species very close to Takifugu rubripes and suitable for studying osmoregulation.
Kato A, Doi H, Nakada T, Sakai H, Hirose S
BMC physiology, 5, 18, 2005年12月, 査読有り - Roles of Slc13a1 and Slc26a1 sulfate transporters of eel kidney in sulfate homeostasis and osmoregulation in freshwater.
Nakada T, Zandi-Nejad K, Kurita Y, Kudo H, Broumand V, Kwon CY, Mercado A, Mount DB, Hirose S
American journal of physiology. Regulatory, integrative and comparative physiology, 289(2), R575-R585, 2005年08月, 査読有り - Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis.
Ishizuka M, Ohshima H, Tamura N, Nakada T, Inoue A, Hirose S, Hagiwara H
Biochemical and biophysical research communications, 301(4), 1079-1085, 2003年02月, 査読有り
講演・口頭発表等
