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田中 直樹  タナカ ナオキ

教員組織学術研究院(医学系)電話番号0263-37-2354
教育組織大学院 国際医学研究推進学FAX番号0263-37-2354
職名教授メールアドレスnaopi@shinshu-u.ac.jp
住所〒390-8621 長野県松本市旭 3-1-1ホームページURL

更新日:2023/11/17

プロフィール

COE・クラスタ・
研究グループ
信州大学 社会基盤研究所
研究分野
国際医学研究
肥満・糖尿病・脂肪肝・脂肪肝炎
病態栄養学
肝臓病学
消化器病学
病態医化学
キーワード:非アルコール性脂肪性肝疾患・脂肪肝炎 , NASH , NAFLD , 核内受容体、PPAR , メタボリックシンドローム , 脂肪細胞 , 肝臓病学 , 病態栄養 , 肥満 , 糖尿病
現在の研究課題
国際医学研究・教育
キーワード:オンライン国際共修
非アルコール性脂肪肝炎の病態解析と治療法の開発
キーワード:メタボロミクス , 脂質代謝
栄養素と消化器病
キーワード:トランス脂肪酸、飽和脂肪酸、脂肪肝、メチオニン欠乏食、脂肪肝炎、肝癌、炎症性腸疾患、糖尿病
肥満や脂肪肝を予防する機能性食品
キーワード:肥満 , インスリン抵抗性 , 脂肪肝 , メタボリック症候群
脂肪肝・脂肪肝炎に起因する肝発癌機構の解明と治療法の開発
キーワード:脂質代謝 , 肝線維化 , 肝細胞膨化変性 , p62 , βカテニン
脂質代謝と核内受容体
キーワード:胆汁酸
肝臓と脂肪細胞の相互関係
キーワード:脂肪分解
メタボロミクス
キーワード:メタボロミクス
所属学会
所属学会
日本内科学会
日本消化器病学会
日本肝臓学会
日本病態栄養学会
日本生化学会
日本糖尿病学会
日本医学教育学会

所属学会役職担当
日本肝臓学会 , 評議員
日本消化器病学会 , 評議員
日本病態栄養学会 , 評議員、NSTコーディネーター
学歴
出身大学院
2002 , 信州大学大学院医学系研究科 , 代謝制御学講座

出身学校・専攻等(大学院を除く)
1995 , 信州大学医学部

取得学位
医学博士 , 信州大学大学院医学系研究科

免許・資格等
199505 , 医師免許
受賞学術賞
2020 , 第23回日本病態栄養学会年次学術集会 若手研究会長賞
2015 , The Fellows Award for Research Excellence in NIH
2014 , The Fellows Award for Research Excellence in NIH
2013 , The Fellows Award for Research Excellence in NIH
2010 , 第23回日本消化器病学会奨励賞
2009 , 信州大学医学部松医会賞基礎分野
2008 , 日本肝臓学会第7回Schering-Plough Award基礎分野優秀賞
2007 , ウイルス肝炎研究財団 研究助成
研究職歴等
研究職歴
2014- , 信州大学大学院医学系研究科代謝制御学講座 准教授
2009-2012 , 信州大学大学院医学系研究科代謝制御学講座 助教(留学に伴う休職)
2006-2009 , 信州大学大学院医学系研究科代謝制御学講座 助教
2005-2006 , 信州大学医学部消化器内科 医員
2003-2005 , 昭和伊南総合病院内科
2002-2003 , 信州大学医学部消化器内科 医員
1995-1996 , 信州大学医学部内科 研修医

留学歴
2009-2014 , 米国国立衛生研究所 癌研究施設 代謝研究部門 客員研究員

研究活動業績

研究業績(著書・
発表論文等)
論文
多機能性分子・硫酸化糖脂質の機能と制御
信州医学雑誌,71(3):137-147 2023(Jun.)
Author:中嶌岳郎, 田中直樹


2-Step PLT16-AST44 method: Simplified liver fibrosis detection system in patients with non-alcoholic fatty liver disease
HEPATOLOGY RESEARCH,52(4):352-363 2022(Apr.)
Author:Fujimori, Naoyuki; Kimura, Takefumi; Tanaka, Naoki; Yamazaki, Tomoo; Okumura, Taiki; Kobayashi, Hiroyuki; Wakabayashi, Shun-Ichi; Yamashita, Yuki; Sugiura, Ayumi; Pham, Jonathan; Pydi, Sai P.; Sano, Kenji; Joshita, Satoru; Umemura, Takeji;
Keywords:APRI; AST; aspartate aminotransferase; biomarker; FIB-4; general practice; hyaluronic acid; MAFLD; metabolic dysfunction-associated fatty liver disease; NAFLD; NASH; non-alcoholic steatohepatitis; PLT; platelet; type 4 collagen 7S;


Serum Sulfatide Levels as a Biomarker of Active Glomerular Lesion in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single Center Pilot Study
JOURNAL OF CLINICAL MEDICINE,11(3):762 2022(Feb.)
Author:Harada, Makoto; Nakajima, Takero; Yamada, Yosuke; Aomura, Daiki; Yamaguchi, Akinori; Sonoda, Kosuke; Tanaka, Naoki; Hashimoto, Koji; Kamijo, Yuji;
Keywords:serum sulfatides; anti-neutrophil cytoplasmic antibody-associated vasculitis; crescentic glomerulonephritis;


Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice
ENGINEERING,7(12):1797-1805 2021(Dec.)
Author:Diao, Pan; Jia, Fangping; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakajima, Takero; Aoyama, Toshifumi; Moriya, Kyoji; Koike, Kazuhiko; Tanaka, Naoki;
Keywords:Steatosis; Hepatocellular carcinoma; Trans fatty acid; Saturated fatty acid; Dietary restriction; HCV core protein;


Mucosal defect size predicts the adequacy of resection of <= 10 mm nonpedunculated colorectal polyps using a new cold snare polypectomy technique
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY,33:E484-E489 2021(Dec.)
Author:Kudo, Takahiro; Horiuchi, Akira; Kyodo, Reiko; Tokita, Kazuhide; Tanaka, Naoki; Horiuchi, Ichitaro; Sano, Kenji;
Keywords:cold snare polypectomy; colorectal polyp; mucosal layer;


Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,22(19):10303 2021(Oct.)
Author:Jia, Fangping; Hu, Xiao; Kimura, Takefumi; Tanaka, Naoki;
Keywords:fatty liver; NASH; dietary fat; cholesterol; saturated fatty acid; trans fatty acid;


Linked colour imaging versus white-light colonoscopy for the detection of flat colorectal lesions: A randomized controlled trial
COLORECTAL DISEASE,23(6):1414-1420 2021(Jun.)
Author:Kudo, Takahiro; Horiuchi, Akira; Kyodo, Reiko; Horiuchi, Ichitaro; Arai, Nobuyasu; Kajiyama, Masashi; Tanaka, Naoki;
Keywords:colonoscopy; colorectal adenoma; colorectal polyp; adenoma detection rate; linked colour imaging;


Pemafibrate Protects against Fatty Acid-Induced Nephropathy by Maintaining Renal Fatty Acid Metabolism
METABOLITES,11(6):372 2021(Jun.)
Author:Aomura, Daiki; Harada, Makoto; Yamada, Yosuke; Nakajima, Takero; Hashimoto, Koji; Tanaka, Naoki; Kamijo, Yuji;
Keywords:pemafibrate; peroxisomal proliferator-activated receptor alpha; renal fatty acid metabolism; lipotoxicity; nephrology;


Serum thrombospondin 2 is a novel predictor for the severity in the patients with NAFLD
LIVER INTERNATIONAL,41(3):505-514 2021(Mar.)
Author:Kimura, Takefumi; Tanaka, Naoki; Fujimori, Naoyuki; Yamazaki, Tomoo; Katsuyama, Takahito; Iwashita, Yuichi; Pham, Jonathan; Joshita, Satoru; Pydi, Sai P.; Umemura, Takeji;
Keywords:ballooning; biomarker; fibrosis; MAFLD; NAFLD; NAS; NASH; thrombospondin 2;


Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment of Non-Alcoholic Fatty Liver Disease
FRONTIERS IN ENDOCRINOLOGY,12:773432 2021
Author:Kimura, Takefumi; Singh, Simran; Tanaka, Naoki; Umemura, Takeji;
Keywords:hepatic stellate cells (HSC); GPCR (G protein coupled receptor); NAFLD (non-alcoholic fatty liver disease); non-alcoholic steatohepatitis (NASH); liver; fibrosis; metabolism;


A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice
JOURNAL OF NUTRITIONAL BIOCHEMISTRY,85 2020(Nov.)
Author:Diao, Pan; Wang, Xiaojing; Jia, Fangping; Kimura, Takefumi; Hu, Xiao; Shirotori, Saki; Nakamura, Ibuki; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifumi; Tanaka, Naoki;
Keywords:Lipogenesis; NF-kappa B; Cydin D1; p62; JNK; HCC;


Metabolic Functions of G Protein-Coupled Receptors in Hepatocytes-Potential Applications for Diabetes and NAFLD
BIOMOLECULES,10(10) 2020(Oct.)
Author:Kimura, Takefumi; Pydi, Sai P.; Pham, Jonathan; Tanaka, Naoki;
Keywords:G protein-coupled receptor; GPCR; hepatocyte; liver; metabolism; diabetes; NAFLD; NASH;


Invasive liver abscess syndrome accompanied by spondylodiscitis: a case report and review of the literature
Clin J Gastroenterol,13(5):927-934 2020(Oct.)
Author:Wakabayashi SI, Kimura T, Tanaka N, Pham J, Tanaka T, Higuchi S, Kobayashi J, Umemura T, Iijima A.


Non-alcoholic fatty liver disease later diagnosed as myotonic dystrophy
World J Hepatol. 2020 Sep 27;12(9):685-692. doi: 10.4254/wjh.v12.i9.685.,12(9):685-692 2020(Sep.)
Author:Tanaka N, Kimura T, Fujimori N, Ichise Y, Sano K, Horiuchi A.


Acute liver failure with severe steatosis induced by mushroom
LIVER INTERNATIONAL,40(9):2291-2292 2020(Sep.)
Author:Wakabayashi, Shun-ichi; Kimura, Takefumi; Tanaka, Naoki;


Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice
LIVER CANCER,9(5):529-548 2020(Sep.)
Author:Jia, Fangping; Diao, Pan; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakamuta, Makoto; Nakamura, Ibuki; Shirotori, Saki; Sato, Yoshiko; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Nakayama, Jun; Aoyama, Toshifumi; Tanaka, Naoki;
Keywords:NF-kappa B; STAT3; Cyclin D1; p62/SQSTM1; Senescence;


Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation
FASEB JOURNAL,34(7):9594-9614 2020(Jul.)
Author:Wang, Yaping; Nakajima, Takero; Diao, Pan; Yamada, Yosuke; Nakamura, Kozo; Nakayama, Jun; Tanaka, Naoki; Aoyama, Toshifumi; Kamijo, Yuji;


Congestive hepatopathy and acute pancreatitis as severe complications of mixed connective tissue disease
Clin J Gastroenterol,13(3):434-442 2020(Jun.)
Author:Kurihara S, Kimura T, Tanaka N, Yanagisawa T, Kobayashi H, Kanai K, Umemura T, Kobayashi M, Mori H, Wada S.


PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(6) 2020(Mar.)
Author:Wang, Yaping; Nakajima, Takero; Gonzalez, Frank J.; Tanaka, Naoki;


A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice
CARCINOGENESIS,41(2):159-170 2020(Feb.)
Author:Hu, Xiao; Wang, Xiaojing; Jia, Fangping; Tanaka, Naoki; Kimura, Takefumi; Nakajima, Takero; Sato, Yoshiko; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Nakayama, Jun; Aoyama, Toshifumi;


Long-term luseogliflozin therapy improves histological activity of non-alcoholic steatohepatitis accompanied by type 2 diabetes mellitus
Clin J Gastroenterol,13(1):83-89 2020(Feb.)
Author:Fujimori N, Tanaka N, Kimura T, Sano K, Horiuchi A, Kato N, Takahashi Y, Kuribayashi N, Sugiura A, Yamazaki T, Joshita S, Umemura T, Matsumoto A, Tanaka E.


Cold snare polypectomy: Indications, devices, techniques, outcomes and future
DIGESTIVE ENDOSCOPY,31(4):372-377 2019(Jul.)
Author:Horiuchi, Akira; Ikuse, Tamaki; Tanaka, Naoki;


A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice
ARCHIVES OF TOXICOLOGY,93(6):1713-1725 2019(Jun.)
Author:Wang, Xiaojing; Tanaka, Naoki; Hu, Xiao; Kimura, Takefumi; Lu, Yu; Jia, Fangping; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Aoyama, Toshifumi;


Safety and Effectiveness of Nurse-Administered Propofol Sedation in Outpatients Undergoing Gastrointestinal Endoscopy
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY,17(6):1098-+ 2019(May)
Author:Sato, Masamichi; Horiuchi, Akira; Tamaki, Michio; Ichise, Yasuyuki; Kajiyama, Masashi; Yamamoto, Yuta; Tanaka, Naoki;


Red plasma and ascites under ultraviolet A
LANCET GASTROENTEROLOGY & HEPATOLOGY,4(4):324-324 2019(Apr.)
Author:Wakabayashi, Shun-ichi; Kimura, Takefumi; Tanaka, Naoki; Komatsu, Michiharu; Tanaka, Eiji;


Peroxisome proliferator-activated receptor attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice
ARCHIVES OF TOXICOLOGY,93(1):149-161 2019(Jan.)
Author:Lu, Yu; Harada, Makoto; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kyogashima, Mamoru; Gonzalez, Frank J.; Aoyama, Toshifumi;


Current status, problems, and perspectives of non-alcoholic fatty liver disease research
WORLD JOURNAL OF GASTROENTEROLOGY,25(2):163-177 2019
Author:Tanaka, Naoki; Kimura, Takefumi; Fujimori, Naoyuki; Nagaya, Tadanobu; Komatsu, Michiharu; Tanaka, Eiji;


Gastric Emptying of Elemental Liquid Diets Versus Semisolid Diets in Bedridden Gastrostomy-fed Patients
JOURNAL OF CLINICAL GASTROENTEROLOGY,53(5):373-378 2019
Author:Horiuchi, Akira; Sakai, Ryosei; Tamaki, Michio; Kajiyama, Masashi; Tanaka, Naoki; Morikawa, Akio;


Miglitol attenuates non-alcoholic steatohepatitis in diabetic patients
HEPATOLOGY RESEARCH,48(13):1092-1098 2018(Dec.)
Author:Komatsu, Michiharu; Tanaka, Naoki; Kimura, Takefumi; Fujimori, Naoyuki; Sano, Kenji; Horiuchi, Akira; Sugiura, Ayumi; Yamazaki, Tomoo; Shibata, Soichiro; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji;


Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.
Hepatol Commun,2(12):1567-1582 2018(Oct.)
Author:Takahashi S, Tanaka N, Fukami T, Xie C, Yagai T, Kim D, Velenosi TJ, Yan T, Krausz KW, Levi M, Gonzalez FJ.


Emergence of anti-mitochondrial M2 antibody in patient with angioimmunoblastic T-cell lymphoma.
Clin J Gastroenterol,11(4):302-308 2018(Aug.)
Author:Wakabayashi SI, Kimura T, Tanaka N, Joshita S, Kawata K, Umemura T, Hiroshima Y, Mori H, Kobayashi H, Wada S, Tanaka E.


Delayed Bleeding Following Cold Snare Polypectomy for Small Colorectal Polyps in Patients Taking Antithrombotic Agents
JOURNAL OF CLINICAL GASTROENTEROLOGY,52(6):502-507 2018(Jul.)
Author:Makino, Toshiyuki; Horiuchi, Akira; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Maetani, Iruru;


Salmonella Enteritidis cholecystitis with chronic granulomatous disease.
IDCases,12:12:49-52 2018(May)
Author:Yamashita Y, Kimura T, Tanaka N, Yazaki M, Itagaki T, Joshita S, Umemura T, Matsumoto A, Mori H, Wada S, Tanaka E.


Mild drinking habit is a risk factor for hepatocarcinogenesis in non-alcoholic fatty liver disease with advanced fibrosis
WORLD JOURNAL OF GASTROENTEROLOGY,24(13):1440-1450 2018(Apr.)
Author:Kimura, Takefumi; Tanaka, Naoki; Fujimori, Naoyuki; Sugiura, Ayumi; Yamazaki, Tomoo; Joshita, Satoru; Komatsu, Michiharu; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji;


Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease
WORLD JOURNAL OF GASTROENTEROLOGY,24(11):1239-1249 2018(Mar.)
Author:Fujimori, Naoyuki; Umemura, Takeji; Kimura, Takefumi; Tanaka, Naoki; Sugiura, Ayumi; Yamazaki, Tomoo; Joshita, Satoru; Komatsu, Michiharu; Usami, Yoko; Sano, Kenji; Igarashi, Koji; Matsumoto, Akihiro; Tanaka, Eiji;


Hepatic Angiosarcoma with Kasabach-Merritt Phenomenon: A Case Report and Review of the Literature
ANNALS OF HEPATOLOGY,17(4):655-660 2018
Author:Fujii, Fumika; Kimura, Takefumi; Tanaka, Naoki; Kubota, Daisuke; Sugiura, Ayumi; Umemura, Takeji; Wada, Shuichi; Tanaka, Eiji;


Growth arrest and DNA damage-inducible 45 alpha protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,1863(12):3170-3182 2017(Dec.)
Author:Tanaka, Naoki; Takahashi, Shogo; Hu, Xiao; Lu, Yu; Fujimori, Naoyuki; Golla, Srujana; Fang, Zhong-Ze; Aoyama, Toshifumi; Krausz, Kristopher W.; Gonzalez, Frank J.;


Targeting nuclear receptors for the treatment of fatty liver disease
PHARMACOLOGY & THERAPEUTICS,179:142-157 2017(Nov.)
Author:Tanaka, Naoki; Aoyama, Toshifumi; Kimura, Shioko; Gonzalez, Frank J.;


Association between lower air pressure and the onset of ischemic colitis: a case-control study
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY,29(9):1071-1078 2017(Sep.)
Author:Kimura, Takefumi; Shinji, Akihiro; Tanaka, Naoki; Koinuma, Masayoshi; Yamaura, Maki; Nagaya, Tadanobu; Joshita, Satoru; Komatsu, Michiharu; Umemura, Takeji; Horiuchi, Akira; Wada, Shuichi; Tanaka, Eiji;


Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway
TOXICOLOGICAL SCIENCES,158(2):334-346 2017(Aug.)
Author:Takahashi, Shogo; Tanaka, Naoki; Golla, Srujana; Fukami, Tatsuki; Krausz, Kristopher W.; Polunas, Marianne A.; Weig, Blair C.; Masuo, Yusuke; Xie, Cen; Jiang, Changtao; Gonzalez, Frank J.;


Decreased Fatty Acid beta-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE,242(3):229-239 2017(Jul.)
Author:Nakajima, Takero; Yang, Yang; Lu, Yu; Kamijo, Yuji; Yamada, Yosuke; Nakamura, Kozo; Koyama, Masahiro; Yamaguchi, Shohei; Sugiyama, Eiko; Tanaka, Naoki; Aoyama, Toshifumi;


Role of the lipid-regulated NF-kappa B/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury
ARCHIVES OF TOXICOLOGY,91(5):2235-2244 2017(May)
Author:Fang, Zhong-Ze; Tanaka, Naoki; Lu, Dan; Jiang, Chang-Tao; Zhang, Wei-Hua; Zhang, Chunze; Du, Zuo; Fu, Zhi-Wei; Gao, Peng; Cao, Yun-Feng; Sun, Hong-Zhi; Zhu, Zhi-Tu; Cai, Yan; Krausz, Kristopher W.; Yao, Zhi; Gonzalez, Frank J.;


Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection
HEPATOLOGY RESEARCH,47(5):405-418 2017(Apr.)
Author:Kimura, Takefumi; Kobayashi, Akira; Tanaka, Naoki; Sano, Kenji; Komatsu, Michiharu; Fujimori, Naoyuki; Yamazaki, Tomoo; Shibata, Soichiro; Ichikawa, Yuki; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Horiuchi, Akira; Mori, Hiromitsu; Wada, Shuichi; Kiyosawa, Kendo; Miyagawa, Shin-ichi; Tanaka, Eiji;


PPAR alpha protects against trans-fatty-acid-containing diet-induced steatohepatitis
JOURNAL OF NUTRITIONAL BIOCHEMISTRY,39:77-85 2017(Jan.)
Author:Hu, Xiao; Tanaka, Naoki; Guo, Ran; Lu, Yu; Nakajima, Takero; Gonzalez, Frank J.; Aoyama, Toshifumi;


Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 2017
Author:Maruyama, Masafumi; Tanaka, Naoki; Kubota, Daisuke; Miyajima, Masayuki; Kimura, Takefumi; Tokutake, Koujiro; Imai, Ryujiro; Fujisawa, Toru; Mori, Hiromitsu; Matsuda, Yoshiaki; Wada, Shuichi; Horiuchi, Akira; Kiyosawa, Kendo;


Association between endotoxemia and histological features of nonalcoholic fatty liver disease
WORLD JOURNAL OF GASTROENTEROLOGY,23(4):712-722 2017
Author:Kitabatake, Hiroyuki; Tanaka, Naoki; Fujimori, Naoyuki; Komatsu, Michiharu; Okubo, Ayaka; Kakegawa, Kyogo; Kimura, Takefumi; Sugiura, Ayumi; Yamazaki, Tomoo; Shibata, Soichiro; Ichikawa, Yuki; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Koinuma, Masayoshi; Sano, Kenji; Aoyama, Toshifumi; Tanaka, Eiji;


Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption
TOXICOLOGY,386:133-142 2017
Author:Wang, Haina; Fang, Zhong-Ze; Meng, Ran; Cao, Yun-Feng; Tanaka, Naoki; Krausz, Kristopher W.; Gonzalez, Frank J.;


PPAR alpha-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice
ARCHIVES OF TOXICOLOGY,90(12):3061-3071 2016(Dec.)
Author:Harada, Yukiko; Tanaka, Naoki; Ichikawa, Motoki; Kamijo, Yuji; Sugiyama, Eiko; Gonzalez, Frank J.; Aoyama, Toshifumi;


Age-dependent PPAR alpha activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene
GLYCOCONJUGATE JOURNAL,33(6):927-936 2016(Dec.)
Author:Tian, Yangyang; Yang, Yang; Zhang, Xiaowei; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Lu, Yu; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifumi;


Activation of PPAR alpha by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE,240(2):113-122 2016(Oct.)
Author:Yang, Yang; Feng, Yuyao; Zhang, Xiaowei; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Aoyama, Toshifumi;


Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non-alcoholic fatty liver disease with none-to-mild obesity and liver fibrosis
HEPATOLOGY RESEARCH,46(10):1019-1027 2016(Sep.)
Author:Fujimori, Naoyuki; Tanaka, Naoki; Shibata, Soichiro; Sano, Kenji; Yamazaki, Tomoo; Sekiguchi, Tomohiro; Kitabatake, Hiroyuki; Ichikawa, Yuki; Kimura, Takefumi; Komatsu, Michiharu; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji;


Comparison between endoscopic mucosal resection and hot snare resection of large nonpedunculated colorectal polyps: a randomized trial
ENDOSCOPY,48(7):646-651 2016(Jul.)
Author:Horiuchi, Akira; Makino, Toshiyuki; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Graham, David Y.;


Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression
TOXICOLOGY AND APPLIED PHARMACOLOGY,291:21-27 2016
Author:Fang, Zhong-Ze; Zhang, Dunfang; Cao, Yun-Feng; Xie, Cen; Lu, Dan; Sun, Dong-Xue; Tanaka, Naoki; Jiang, Changtao; Chen, Qianming; Chen, Yu; Wang, Haina; Gonzalez, Frank J.;


Prospective, randomized comparison of 2 methods of cold snare polypectomy for small colorectal polyps
GASTROINTESTINAL ENDOSCOPY,82(4):686-692 2015(Oct.)
Author:Horiuchi, Akira; Hosoi, Kenji; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Graham, David Y.;


Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans
GASTROENTEROLOGY,149(4):1030-U367 2015(Oct.)
Author:Xu, Ming-Jiang; Cai, Yan; Wang, Hua; Altamirano, Jose; Chang, Binxia; Bertola, Adeline; Odena, Gemma; Lu, Jim; Tanaka, Naoki; Matsusue, Kimihiko; Matsubara, Tsutomu; Mukhopadhyay, Partha; Kimura, Shioko; Pacher, Pal; Gonzalez, Frank J.; Bataller, Ramon; Gao, Bin;


St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
CANCER PREVENTION RESEARCH,8(9):786-795 2015(Sep.)
Author:Manna, Soumen K.; Golla, Srujana; Golla, Jaya Prakash; Tanaka, Naoki; Cai, Yan; Takahashi, Shogo; Krausz, Kristopher W.; Matsubara, Tsutomu; Korboukh, Ilia; Gonzalez, Frank J.;


Primary hepatocellular carcinoma in a patient with neurofibromatosis type I
LIVER INTERNATIONAL,35(8):2057-2058 2015(Aug.)
Author:Kimura, Takefumi; Tanaka, Naoki; Umemura, Takeji; Tanaka, Eiji;


Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation
ENVIRONMENTAL HEALTH PERSPECTIVES,123(7):679-688 2015(Jul.)
Author:Zhang, Limin; Nichols, Robert G.; Correll, Jared; Murray, Iain A.; Tanaka, Naoki; Smith, Philip B.; Hubbard, Troy D.; Sebastian, Aswathy; Albert, Istvan; Hatzakis, Emmanuel; Gonzalez, Frank J.; Perdew, Gary H.; Patterson, Andrew D.;


Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,1852(7):1242-1252 2015(Jul.)
Author:Tanaka, Naoki; Takahashi, Shogo; Zhang, Yuan; Krausz, Kristopher W.; Smith, Philip B.; Patterson, Andrew D.; Gonzalez, Frank J.;


Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPAR alpha
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,1852(3):473-481 2015(Mar.)
Author:Komatsu, Michiharu; Kimura, Takefumi; Yazaki, Masahide; Tanaka, Naoki; Yang, Yang; Nakajima, Takero; Horiuchi, Akira; Fang, Zhong-Ze; Joshita, Satoru; Matsumoto, Akihiro; Umemura, Takeji; Tanaka, Eiji; Gonzalez, Frank J.; Ikeda, Shu-Ichi; Aoyama, Toshifumi;


Helicobacter pylori-negative Differentiated Adenocarcinoma of the Stomach
INTERNAL MEDICINE,54(22):2857-2862 2015
Author:Nagaya, Tadanobu; Tanaka, Naoki; Iwaya, Yugo; Jimbo, Yoko; Tatai, Toshiharu; Ito, Tetsuya; Seki, Ayako; Suzawa, Kenichi; Ochi, Yasuhide; Hara, Etsuo; Takata, Manabu; Otsuki, Toshiaki; Iwaya, Mai; Hosaka, Noriko; Arakura, Norikazu; Tanaka, Eiji; Hasebe, Osamu;


Adipocyte-specific Disruption of Fat-specific Protein 27 Causes Hepatosteatosis and Insulin Resistance in High-fat Diet-fed Mice
JOURNAL OF BIOLOGICAL CHEMISTRY,290(5):3092-3105 2015
Author:Tanaka, Naoki; Takahashi, Shogo; Matsubara, Tsutomu; Jiang, Changtao; Sakamoto, Wataru; Chanturiya, Tatyana; Teng, Ruifeng; Gavrilova, Oksana; Gonzalez, Frank J.;


Metabolic mapping of A(3) adenosine receptor agonist MRS5980
BIOCHEMICAL PHARMACOLOGY,97(2):215-223 2015
Author:Fang, Zhong-Ze; Tosh, Dilip K.; Tanaka, Naoki; Wang, Haina; Krausz, Kristopher W.; O'Connor, Robert; Jacobson, Kenneth A.; Gonzalez, Frank J.;


Comparison of newly found polyps after removal of small colorectal polyps with cold or hot snare polypectomy
ACTA GASTRO-ENTEROLOGICA BELGICA,78(4):406-410 2015
Author:Horiuchi, Akira; Makino, Toshiyuki; Ichise, Yasuyuki; Kajiyama, Masashi; Kato, Naoyuki; Tanaka, Naoki;


Activation of Intestinal Human Pregnane X Receptor Protects against Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,351(3):559-567 2014(Dec.)
Author:Cheng, Jie; Fang, Zhong-Ze; Nagaoka, Kenjiro; Okamoto, Minoru; Qu, Aijuan; Tanaka, Naoki; Kimura, Shioko; Gonzalez, Frank J.;


Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,1841(11):1596-1607 2014(Nov.)
Author:Tanaka, Naoki; Takahashi, Shogo; Fang, Zhong-Ze; Matsubara, Tsutomu; Krausz, Kristopher W.; Qu, Aijuan; Gonzalez, Frank J.;


Biliary stenting as alternative therapy to stone clearance in elderly patients with bile duct stones
ACTA GASTRO-ENTEROLOGICA BELGICA,77(3):297-301 2014(Sep.)
Author:Horiuchi, Akira; Kajiyama, Masashi; Ichise, Yasuyuki; Tada, Haruyo; Fujiwara, Naoyuki; Tanaka, Naoki;


Laparoscopic findings of congenital hepatic fibrosis: A case report and review of the published work
HEPATOLOGY RESEARCH,44(7):818-824 2014(Jul.)
Author:Komatsu, Michiharu; Tanaka, Naoki; Shibata, So-Ichirou; Kimura, Takefumi; Ichikawa, Yuki; Morita, Susumu; Joshita, Satoru; Nagaya, Tadanobu; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Tanaka, Eiji;


Biomarkers of Coordinate Metabolic Reprogramming in Colorectal Tumors in Mice and Humans
GASTROENTEROLOGY,146(5):1313-1324 2014(May)
Author:Manna, Soumen K.; Tanaka, Naoki; Krausz, Kristopher W.; Haznadar, Majda; Xue, Xiang; Matsubara, Tsutomu; Bowman, Elise D.; Fearon, Eric R.; Harris, Curtis C.; Shah, Yatrik M.; Gonzalez, Frank J.;


In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract
BRITISH JOURNAL OF PHARMACOLOGY,171(7):1735-1746 2014(Apr.)
Author:Fang, Zhong-Ze; Krausz, Kristopher W.; Nagaoka, Kenjiro; Tanaka, Naoki; Gowda, Krishne; Amin, Shantu G.; Perdew, Gary H.; Gonzalez, Frank J.;


Removal of small colorectal polyps in anticoagulated patients: a prospective randomized comparison of cold snare and conventional polypectomy
GASTROINTESTINAL ENDOSCOPY,79(3):417-423 2014(Mar.)
Author:Horiuchi, Akira; Nakayama, Yoshiko; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Graham, David Y.;


Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice
JOURNAL OF LIPID RESEARCH,55(3):455-465 2014(Mar.)
Author:Cheng, Jie; Fang, Zhong-Ze; Kim, Jung-Hwan; Krausz, Kristopher W.; Tanaka, Naoki; Chiang, John Y. L.; Gonzalez, Frank J.;


Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice
ARCHIVES OF TOXICOLOGY,88(2):367-379 2014(Feb.)
Author:Kanbe, Hiroki; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Wang, Lixuan; Fang, Zhong-Ze; Hara, Atsushi; Gonzalez, Frank J.; Aoyama, Toshifumi;


Role of Myc in hepatocellular proliferation and hepatocarcinogenesis
JOURNAL OF HEPATOLOGY,60(2):331-338 2014(Feb.)
Author:Qu, Aijuan; Jiang, Changtao; Cai, Yan; Kim, Jung-Hwan; Tanaka, Naoki; Ward, Jerrold M.; Shah, Yatrik M.; Gonzalez, Frank J.;


Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7
TOXICOLOGY AND APPLIED PHARMACOLOGY,277(1):86-94 2014
Author:Ma, Hai-Ying; Sun, Dong-Xue; Cao, Yun-Feng; Ai, Chun-Zhi; Qu, Yan-Qing; Hu, Cui-Min; Jiang, Changtao; Dong, Pei-Pei; Sun, Xiao-Yu; Hong, Mo; Tanaka, Naoki; Gonzalez, Frank J.; Ma, Xiao-Chi; Fang, Zhong-Ze;


PPAR alpha-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY,307(5):G564-G573 2014
Author:Qi, Yunpeng; Jiang, Changtao; Tanaka, Naoki; Krausz, Kristopher W.; Brocker, Chad N.; Fang, Zhong-Ze; Bredell, Bryce X.; Shah, Yatrik M.; Gonzalez, Frank J.;


Improving quality measures in colonoscopy and its therapeutic intervention
WORLD JOURNAL OF GASTROENTEROLOGY,20(36):13027-13034 2014
Author:Horiuchi, Akira; Tanaka, Naoki;


Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-kappa B and STAT3 signaling
CHEMICO-BIOLOGICAL INTERACTIONS,223:80-86 2014
Author:Liu, Aiming; Tanaka, Naoki; Sun, Lu; Guo, Bin; Kim, Jung-Hwan; Krausz, Kristopher W.; Fang, Zhongze; Jiang, Changtao; Yang, Julin; Gonzalez, Frank J.;


A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders
JOURNAL OF LIPID RESEARCH,54(12):3334-3344 2013(Dec.)
Author:Fang, Zhong-Ze; He, Rong-Rong; Cao, Yun-Feng; Tanaka, Naoki; Jiang, Changtao; Krausz, Kristopher W.; Qi, Yunpeng; Dong, Pei-Pei; Ai, Chun-Zhi; Sun, Xiao-Yu; Hong, Mo; Ge, Guang-Bo; Gonzalez, Frank J.; Ma, Xiao-Chi; Sun, Hong-Zhi;


Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum
ARCHIVES OF TOXICOLOGY,87(11):1975-1987 2013(Nov.)
Author:Fang, Zhong-Ze; Krausz, Kristopher W.; Tanaka, Naoki; Li, Fei; Qu, Aijuan; Idle, Jeffrey R.; Gonzalez, Frank J.


Peroxisome proliferator-activated receptor alpha mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
GLYCOCONJUGATE JOURNAL,30(6):553-560 2013(Aug.)
Author:Nakajima, Takero; Kamijo, Yuji; Huang Yuzhe; Kimura, Takefumi; Tanaka, Naoki; Sugiyama, Eiko; Nakamura, Kozo; Kyogashima, Mamoru; Hara, Atsushi; Aoyama, Toshifumi;


Safety and Effectiveness of Low-Dose Propofol Sedation During and After Esophagogastroduodenoscopy in Child A and B Cirrhotic Patients
DIGESTIVE DISEASES AND SCIENCES,58(5):1383-1389 2013(May)
Author:Tanaka, Naoki; Horiuchi, Akira; Nakayama, Yoshiko; Katsuyama, Yoshihiko; Isobe, Masatsugu; Aoyama, Toshifumi; Tanaka, Eiji; Ohmori, Shigeru


TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury
JOURNAL OF LIPID RESEARCH,53(12):2698-2707 2012(Dec.)
Author:Matsubara, Tsutomu; Tanaka, Naoki; Sato, Misako; Kang, Dong Wook; Krausz, Kristopher W.; Flanders, Kathleen C.; Ikeda, Kazuo; Luecke, Hans; Wakefield, Lalage M.; Gonzalez, Frank J.


Metabolomics Identifies an Inflammatory Cascade Involved in Dioxin- and Diet-Induced Steatohepatitis
CELL METABOLISM,16(5):634-644 2012(Nov. 07)
Author:Matsubara, Tsutomu; Tanaka, Naoki; Krausz, Kristopher W.; Manna, Soumen K.; Kang, Dong Wook; Anderson, Erik R.; Luecke, Hans; Patterson, Andrew D.; Shah, Yatrik M.; Gonzalez, Frank J.


Metabolomics reveals an essential role for peroxisome proliferator-activated receptor alpha in bile acid homeostasis
JOURNAL OF LIPID RESEARCH,53(8):1625-1635 2012(Aug.)
Author:Li, Fei; Patterson, Andrew D.; Krausz, Kristopher W.; Tanaka, Naoki; Gonzalez, Frank J.


Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
HEPATOLOGY,56(1):118-129 2012(Jul.)
Author:Tanaka, Naoki; Matsubara, Tsutomu; Krausz, Kristopher W.; Patterson, Andrew D.; Gonzalez, Frank J.


Clinical Characteristics of Young-Onset Ischemic Colitis
DIGESTIVE DISEASES AND SCIENCES,57(6):1652-1659 2012(Jun.)
Author:Kimura, Takefumi; Shinji, Akihiro; Horiuchi, Akira; Tanaka, Naoki; Nagaya, Tadanobu; Shigeno, Takashi; Nakamura, Naoshi; Komatsu, Michiharu; Umemura, Takeji; Arakura, Norikazu; Matsumoto, Akihiro; Tanaka, Eiji


PPAR alpha is down-regulated following liver transplantation in mice
JOURNAL OF HEPATOLOGY,56(3):586-594 2012(Mar.)
Author:Nakagawa, Kan; Tanaka, Naoki; Morita, Miwa; Sugioka, Atsushi; Miyagawa, Shin-ichi; Gonzalez, Frank J.; Aoyama, Toshifumi


Clinical characteristics of de novo nonalcoholic fatty liver disease following pancreaticoduodenectomy
JOURNAL OF GASTROENTEROLOGY,46(6):758-768 2011(Jun.)
Author:Tanaka, Naoki; Horiuchi, Akira;Yokoyama, Takahide; Kaneko, Gengo; Horigome, Naoto; Yamaura, Takahiro; Nagaya, Tadanobu; Komatsu, Michiharu; Sano, Kenji; Miyagawa, Shin-ichi; Aoyama, Toshifumi; Tanaka, Eiji


Lithocholic Acid Disrupts Phospholipid and Sphingolipid Homeostasis Leading to Cholestasis in Mice
HEPATOLOGY,53(4):1282-1293 2011(Apr.)
Author:Matsubara, Tsutomu; Tanaka, Naoki; Patterson, Andrew D.; Cho, Joo-Youn; Krausz, Kristopher W.; Gonzalez, Frank J.


Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease
JOURNAL OF GASTROENTEROLOGY,45(12):1263-1271 2010(Dec.)
Author:Hatta, Tomoko; Fujinaga, Yasunari; Kadoya, Masumi; Ueda, Hitoshi; Murayama, Hiroaki; Kurozumi, Masahiro; Ueda, Kazuhiko; Komatsu, Michiharu; Nagaya, Tadanobu; Joshita, Satoru; Kodama, Ryo; Tanaka, Eiji; Uehara, Tsuyoshi; Sano, Kenji; Tanaka, Naoki


Eicosapentaenoic acid improves hepatic steatosis independent of PPAR alpha activation through inhibition of SREBP-1 maturation in mice
BIOCHEMICAL PHARMACOLOGY,80(10):1601-1612 2010(Nov. 15)
Author:Tanaka, Naoki; Zhang, Xiuguo; Sugiyama, Eiko; Kono, Hiroyuki; Horiuchi, Akira; Nakajima, Takero; Kanbe, Hiroki; Tanaka, Eiji; Gonzalez, Frank J.; Aoyama, Toshifumi


Down-regulation of SREBP-1c is associated with the development of burned-out NASH
JOURNAL OF HEPATOLOGY,53(4):724-731 2010(Oct.)
Author:Nagaya, Tadanobu; Tanaka, Naoki; Suzuki, Takefumi; Sano, Kenji; Horiuchi, Akira; Komatsu, Michiharu; Nakajima, Takero; Nishizawa, Tomoko; Joshita, Satoru; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Nakayama, Jun; Tanaka, Eiji; Aoyama, Toshifumi


Serum Fragmented Cytokeratin 18 Levels Reflect the Histologic Activity Score of Nonalcoholic Fatty Liver Disease More Accurately Than Serum Alanine Aminotransferase Levels
JOURNAL OF CLINICAL GASTROENTEROLOGY,44(6):440-447 2010(Jul.)
Author:Tsutsui, Masaru; Tanaka, Naoki; Kawakubo, Masatomo; Sheena, Yo; Horiuchi, Akira; Komatsu, Michiharu; Nagaya, Tadanobu; Joshita, Satoru; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Tanaka, Eiji; Sano, Kenji


Nonalcoholic fatty liver disease in Japanese junior high school students: its prevalence and relationship to lifestyle habits
JOURNAL OF GASTROENTEROLOGY,45(6):666-672 2010(Jun.)
Author:Tsuruta, Goro; Tanaka, Naoki; Hongo, Minoru; Komatsu, Michiharu; Horiuchi, Akira; Hamamoto, Kaeko; Iguchi, Chieko; Nakayama, Yoshiko; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Tanaka, Eiji


一般中学生の高尿酸血症と生活習慣病との関連
痛風と核酸代謝 = Gout and nucleic acid metabolism,33(1):17-26 2009(Jul. 01)
Author:本郷 実,日高 宏哉,阪口 しげ子,市川 元基,池田 宇一,田中 直樹,鶴田 悟郎,小池 健一


Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections
JOURNAL OF GASTROENTEROLOGY,44(6):577-582 2009(Jun.)
Author:Tanaka, Naoki; Horiuchi, Akira; Yamaura, Takahiro; Komatsu, Michiharu; Yokoyama, Takahide; Okaniwa, Shinji; Nagaya, Tadanobu; Yoshizawa, Kaname; Kiyosawa, Kendo; Aoyama, Toshifumi; Tanaka, Eiji


Polyenephosphatidylcholine prevents alcoholic liver disease in PPAR alpha-null mice through attenuation of increases in oxidative stress
JOURNAL OF HEPATOLOGY,50(6):1236-1246 2009(Jun.)
Author:Okiyama, Wataru; Tanaka, Naoki; Nakajima, Tamie; Tanaka, Eiji; Kiyosawa, Kendo; Gonzalez, Frank J.; Aoyama, Toshifumi


Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor alpha-Independent Mechanism
MOLECULAR PHARMACOLOGY,75(4):782-792 2009(Apr.)
Author:Nakajima, Takero; Tanaka, Naoki; Kanbe, Hiroki; Hara, Atsushi; Kamijo, Yuji; Zhang, Xiaowei; Gonzalez, Frank J.; Aoyama, Toshifumi


Hepatitis C Virus, Splenic Vein Thrombosis, and Lymphoma
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY,7(2):XXIV-XXIV 2009(Feb.)
Author:Tanaka, Naoki; Yokoyama, Takahide; Horiuchi, Akira


広範囲の肝実質の脱落により奇異な肝形態を呈し自己免疫性肝炎が疑われた1例
日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy,51(1):48-54 2009(Jan. 20)
Author:城下 智,一條 哲也,吉澤 要,福島 万奈,小松 通治,新井 薫,田中 直樹,梅村 武司,松本 晶博,田中 榮司


α型ペルオキシソーム増殖剤活性化受容体(PPARα): 脂肪肝疾患との関連
信州医学雑誌,56(6):347-358 2008(Dec.)
Author:田中直樹,青山俊文
Keywords:nuclear receptor,mitochondrial β-oxidation,oxidative stress,steatohepatitis,hepatitis C virus,核内受容体,ミトコンドリアβ酸化,酸化ストレス,脂肪肝炎,C型肝炎ウイルス


Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease
JOURNAL OF HEPATOLOGY,49(5):810-820 2008(Nov.)
Author:Komatsu, Michiharu; Yazaki, Masahide; Tanaka, Naoki; Sano, Kenji; Hashimoto, Etsuko; Taker, Yo-ichi; Song, Yuan-Zong; Tanaka, Eiji; Kiyosawa, Kendo; Saheki, Takeyori; Aoyama, Toshifumi; Kobayashi, Keiko


Insulin resistance and hepatitis C virus: a case-control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serumaminotransferase
LIVER INTERNATIONAL,28(8):1104-1111 2008(Sep.)
Author:Tanaka, Naoki; Nagaya, Tadanobu; Komatsu, Michiharu; Horiuchi, Akira; Tsuruta, Goro; Shirakawa, Haruaki; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Kiyosawa, Kendo; Tanaka, Eiji


Cholesterol-lowering effectof bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice
BIOCHEMICAL PHARMACOLOGY,76(1):108-119 2008(Jul. 01)
Author:Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Hara, Atsushi; Hu, Rui; Li, Gang; Li, Yufeng; Nakamura, Kozo; Gonzalez, Frank J.; Aoyama, Toshifumi


Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis
JOURNAL OF CLINICAL GASTROENTEROLOGY,42(4):413-418 2008(Apr.)
Author:Tanaka, Naoki; Sano, Kenji; Horiuchi, Akira; Tanaka, Eiji; Kiyosawa, Kendo; Aoyama, Toshifumi


PPAR alpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
JOURNAL OF CLINICAL INVESTIGATION,118(2):683-694 2008(Feb.)
Author:Tanaka, Naoki; Moriya, Kyoji; Kiyosawa, Kendo; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifurni


Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis
INTERNATIONAL JOURNAL OF CANCER,122(1):124-131 2008(Jan. 01)
Author:Tanaka, Naoki; Moriya, Kyoji; Kiyosawa, Kendo; Koike, Kazuhiko; Aoyama, Toshifumi


Pancreatic exocrine insufficiency: A rare cause of nonalcoholic steatohepatitis
AMERICAN JOURNAL OF GASTROENTEROLOGY,103(1):245-246 2008(Jan.)
Author:Tanaka, Naoki; Horiuchi, Akira; Yokoyama, Takahide; Kawa, Shigeyuki; Kiyosawa, Kendo


腹壁への浸潤が疑われ, 画像検査が診断の契機となった肝放線菌症の1例
肝臓 = ACTA HEPATOLOGICA JAPONICA,48(11):553-558 2007(Nov. 25)
Author:武藤 英知,一條 哲也,小林 倫子,田中 直樹,梅村 武司,小松 通治,松本 晶博,吉澤 要,田中 榮司,上田 和彦,角谷 眞澄,清澤 研道


A lean man with nonalcoholic fatty liver disease
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY,5(3):XXXII-XXXII 2007(Mar.)
Author:Tanaka, Naoki; Yazaki, Masahide; Kobayashi, Keiko


Efficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study
JOURNAL OF GASTROENTEROLOGY,42(1):49-55 2007(Jan.)
Author:Tanaka, Naoki; Horiuchi, Akira; Yamaura, Takahiro; Komatsu, Michiharu; Tanaka, Eiji; Kiyosawa, Kendo


Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population
LIVER INTERNATIONAL,26(8):956-963 2006(Oct.)
Author:Tanaka, Naoki; Tanaka, Eiji; Sheena, Yo;Komatsu, Michiharu; Okiyama, Wataru; Misawa, Noriko; Muto, Hidetomo; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Horiuchi, Akira; Kiyosawa, Kendo


Peroxisome proliferator-activated receptor alpha-independent peroxisome proliferation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,346(4):1307-1311 2006(Aug. 11)
Author:Zhang, Xiuguo; Tanaka, Naoki; Nakajuna, Takero; Kamijo, Yuji; Gonzalez, Frank J.; Aoyama, Toshifumi


Laparoscopic findings in patients with nonalcoholic steatohepatitis
LIVER INTERNATIONAL,26(1):32-38 2006(Feb.)
Author:Tanaka, N; Ichijo, T; Okiyama, W; Mutou, H; Misawa, N; Matsumoto, A; Yoshizawa, K; Tanaka, E; Kiyosawa, K


Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage
HEPATOLOGY,40(4):972-980 2004(Oct.)
Author:Nakajima, T; Kamijo, Y; Tanaka, N; Sugiyama, E; Tanaka, E; Kiyosawa, K; Fukushima, Y; Peters, JM; Gonzalez, FJ; Aoyama, T


Phlebotomy: a promising treatment for chronic hepatitis C
JOURNAL OF GASTROENTEROLOGY,39(6):601-603 2004(Jun.)
Author:Tanaka, N; Kiyosawa, K


Ribavirin-induced pure red-cell aplasia during treatment of chronic hepatitis C.
NEW ENGLAND JOURNAL OF MEDICINE,350(12):1264-1265 2004(Mar. 18)
Author:Tanaka, N; Ishida, F; Tanaka, E


In vivo stabilization of nuclear retinoid X receptor alpha in the presence of peroxisome proliferator-activated receptor alpha
FEBS LETTERS,543(1-3):120-124 2003(May 22)
Author:Tanaka,N; Hora, K; Makishima, H; Kamijo, Y; Kiyosawa, K; Gonzalez, FJ; Aoyama, T


Development of hepatocellular carcinoma after longterm sustained complete response to interferon therapy: what is the mechanism?
JOURNAL OF GASTROENTEROLOGY,38(4):417-419 2003(Apr.)
Author:Tanaka, N; Kiyosawa, K


非アルコール性脂肪性肝炎
肝臓,43(12):539-549 2002(Dec. 25)
Author:田中 直樹,清澤 研道


非アルコール性脂肪肝炎の発症機構とPPAR
日本消化器病學會雜誌 = The Japanese journal of gastro-enterology,99(6):563-569 2002(Jun. 05)
Author:田中 直樹,青山 俊文


トピックス 4.Peroxisome proliferator-activated receptor(PPAR)
日本内科学会雑誌,90(10):2033-2039 2001(Oct. 10)
Author:田中 直樹,青山 俊文


Initiation of enzyme replacement therapy for an adult patient with asymptomatic type 1 Gaucher's disease
INTERNAL MEDICINE,40(8):716-721 2001(Aug.)
Author:Tanaka, N; Saito, H; Ito, T; Momose, K; Ishida, F; Hora, K; Kiyosawa, K; Ida, H


Back pain out of the blue in a haemodialysis patient
NEPHROLOGY DIALYSIS TRANSPLANTATION,14(7):1792-1794 1999(Jul.)
Author:Tanaka, N; Kasahara, H; Yoshie, T; Hora, K; Kiyosawa, K

共同研究等希望テーマ
アフターコロナ時代の国際医学交流
非アルコール性脂肪肝疾患、脂肪肝炎 , 大学等との共同研究や企業との技術相談、受託研究も可能。
疾患に対する機能性食品の有効性の検証 , 大学等との共同研究や企業との技術相談、受託研究も可能。
肝線維化・肝癌 , 大学等との共同研究や企業との技術相談、受託研究も可能。
生活習慣病 , 大学等との共同研究や企業との技術相談、受託研究も可能。
脂肪組織 , 大学等との共同研究や企業との技術相談、受託研究も可能。
メタボロミクス・リピドミクス
研究費
共同研究
2004 - , 国際共同研究

科学研究費補助金(研究代表者)
2019 - 2021 , 食事中トランス脂肪酸による肝発癌促進機能の解明と予防法の開発 , 基盤研究(C)
2016 - 2018 , 生体異物代謝を機軸とした非アルコール性脂肪肝炎発症機構の解明 , 基盤研究(C)
2009 - 2010 , PPARα 活性化抑制を標的としたC型肝炎関連肝癌の予防法の開発 , 若手研究(B)
2007 - 2008 , PPARα ノックアウトマウスを用いたアルコール性肝障害の病態解析と治療法の開発 , 若手研究(B)

科学研究費補助金(研究分担者)
2007 - 2008 , 消化管および肝臓におけるアルコール依存的炎症性障害の分子機構の解明と予防法の開発 , 基盤研究(C)
研究諸活動
海外派遣
信州大学医学部顕彰 短期留学 , 米国国立衛生研究所
国際交流 , ドイツ ドレスデン工科大学
国際交流 , インドネシア

教育活動実績

授業等
2021 , 前期 , 生化学
2021 , 前期 , 人間機能・形態学概論
2020 , 前期 , 人間機能・形態学概論
2020 , 前期 , 生化学
2019 , 前期 , 人間機能・形態学概論
2019 , 通年 , 生化学
2018 , 前期 , 人間機能・形態学概論
2018 , 通年 , 生化学
2017 , 前期 , 人間機能・形態学概論
2017 , 前期 , 疾患予防医科学
2017 , 通年 , 生化学
2016 , 前期 , 人間機能・形態学概論
2016 , 前期 , 疾患予防医科学
2016 , 通年 , 生化学
2015 , 前期 , 人間機能・形態学概論
2015 , 前期 , 疾患予防医化学概論
2015 , 通年 , 生化学
2014 , 生化学
論文指導
2021
博士論文指導 指導学生数 計:5(内留学生:4)

2020
修士論文指導 指導学生数 計:1(内留学生:1)
博士論文指導 指導学生数 計:5(内留学生:4)

2019
修士論文指導 指導学生数 計:2(内留学生:2)
博士論文指導 指導学生数 計:5(内留学生:4)

2014
博士論文指導 指導学生数 計:2(内留学生:0)

2012
博士論文指導 指導学生数 計:1(内留学生:0)

2010
博士論文指導 指導学生数 計:5(内留学生:1)

2009
博士論文指導 指導学生数 計:1(内留学生:0)

2008
博士論文指導 指導学生数 計:2(内留学生:0)

2006
博士論文指導 指導学生数 計:1(内留学生:1)

留学生受入
2020 , 前期人数:1 , 後期人数:0 , 2人入学希望、COVID-19 のため1人は入学後休学、もう一人は入試を受験できず。
2019 , 前期人数:2 , 後期人数:0
2018 , 前期人数:1 , 後期人数:1
2017 , 前期人数:2 , 後期人数:2
2016 , 前期人数:2 , 後期人数:2

社会活動実績

社会活動等
公開講座
20180729 - , 本当は怖~い脂肪肝 , 日本肝臓学会甲信越支部 市民公開講座
20170620 - , 食生活と生活習慣病 , 信州ソルガム高度活用研究プロジェクトキックオフシンポジウム
20160703 - , 本当はこわい脂肪肝~小児から大人まで~ , 日本消化器病学会甲信越支部 主催

出前講座
20170122 - , 内臓肥満と糖尿病・高血圧-健診データのみかた–

講演会
20170620 - , 食生活と生活習慣病 , 講師
NAFLD/NASHの病態・診断と今後の展望 , 講師

メディア・報道
20210424 , 長野放送 , 健康ばんざい 肝疾患
20170326 , SBCラジオ , こんにちはドクター『本当にこわい脂肪肝』
20170306 , テレビ信州 , 奥様はホームドクター『本当はこわい脂肪肝』 , 月~金

管理運営実績

管理運営実績
学部内委員会等
2016 - , 医学部国際交流推進室 , 副室長