博士（医学）, 東京大学

ライフサイエンス, 神経科学一般 , 分子神経生物学・神経科学一般

2023年
信州大学基盤研究支援センター　教授

2017年
信州大学基盤研究支援センター　准教授

2014年
信州大学学術研究院医学系 准教授

2013年
信州大学医学部 講師

2007年
東京大学大学院医学系研究科　助教

2005年
東京大学大学院医学系研究科　助手

2003年
東京大学大学院医学系研究科　研究拠点形成特任研究員

2003年, 東京大学

1997年, 東京理科大学

Development of phosphate-treated PEEK implants with high osseointegration
Yu Usuda, Takumi Okihara, Shigeaki Moriyama, Takeshi Uemura, Takayuki Kamanaka, Aoi William Omi, Naoto Saito, Jun Takahashi, Kaoru Aoki, Naoyuki Nishimura
Materials Today Communications, 38, 107717, 2024年03月

Biocompatibility Evaluation of Carbon Nanohorns in Bone Tissues
Ueda, K; Ma, C; Izumiya, M; Kuroda, C; Ishida, H; Uemura, T; Saito, N; Aoki, K; Haniu, H
Nanomaterials, 2023年01月

Neurexins in serotonergic neurons regulate neuronal survival, serotonin transmission, and complex mouse behaviors
Cheung, A; Konno, K; Imamura, Y; Matsui, A; Abe, M; Sakimura, K; Sasaoka, T; Uemura, T; Watanabe, M; Futai, K; Brose, N
Elife, 2023年01月
筆頭著者, 責任著者

Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins
Uemura, Takeshi; Suzuki-Kouyama, Emi; Kawase, Shiori; Kurihara, Taiga; Yasumura, Misato; Yoshida, Tomoyuki; Fukai, Shuya; Yamazaki, Maya; Fei, Peng; Abe, Manabu; Watanabe, Masahiko; Sakimura, Kenji; Mishina, Masayoshi; Tabuchi, Katsuhiko;
CELL REPORTS, 39(1), 110624, 2022年

IQSEC3 Deletion Impairs Fear Memory Through Upregulation of Ribosomal S6K1 Signaling in the Hippocampus
Kim, Dongwook; Jung, Hyeji; Shirai, Yoshinori; Kim, Hyeonho; Kim, Jinhu; Lim, Dongseok; Mori, Takuma; Lee, Hyojeong; Park, Dongseok; Kim, Hee Young; Guo, Qi; Pang, Bo; Qiu, Wen; Cao, Xueshan; Kouyama-Suzuki, Emi; Uemura, Takeshi; Kasem, Enas; Fu, Yu; Kim, Seungjoon; Tokunaga, Akinori; Yoshizawa, Takahiro; Suzuki, Tatsuo; Sakagami, Hiroyuki; Lee, Kea Joo; Ko, Jaewon; Tabuchi, Katsuhiko; Um, Ji Won;
BIOLOGICAL PSYCHIATRY, 91(9), 821-831, 2022年

Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes
Saito, Naoto; Haniu, Hisao; Aoki, Kaoru; Nishimura, Naoyuki; Uemura, Takeshi;
ADVANCED SCIENCE, 2201214, 2022年
最終著者

Evaluation of MC3T3-E1 Cell Osteogenesis in Different Cell Culture Media
Izumiya, Makoto; Haniu, Miyu; Ueda, Katsuya; Ishida, Haruka; Ma, Chuang; Ideta, Hirokazu; Sobajima, Atsushi; Ueshiba, Koki; Uemura, Takeshi; Saito, Naoto; Haniu, Hisao;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14), 2021年07月

Abundant oleoyl-lysophosphatidylethanolamine in brain stimulates neurite outgrowth and protects against glutamate toxicity in cultured cortical neurons
Hisano, Kazutoshi; Yoshida, Hironori; Kawase, Shiori; Mimura, Tetsuhiko; Yoshida, Hironori;Haniu, Hisao; Tsukahara, Tamotsu; Kurihara, Taiga; Matsuda, Yoshikazu; Saito, Naoto; Uemura, Takeshi;
The Journal of Biochemistry, Apr 5;mvab046., 2021年
最終著者, 責任著者

Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades
Hisano, Kazutoshi; Kawase, Shiori; Mimura, Tetsuhiko; Yoshida, Hironori; Yamada, Hiroki; Haniu, Hisao; Tsukahara, Tamotsu; Kurihara, Taiga; Matsuda, Yoshikazu; Saito, Naoto; Uemura, Takeshi;
Biochemical and biophysical research communications, 534, 179-185, 2021年
最終著者, 責任著者

Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
Yoshida, Tomoyuki; Yamagata, Atsushi; Imai, Ayako; Kim, Juhyon; Izumi, Hironori; Nakashima, Shogo; Shiroshima, Tomoko; Maeda, Asami; Iwasawa-Okamoto, Shiho; Azechi, Kenji; Osaka, Fumina; Saitoh, Takashi; Maenaka, Katsumi; Shimada, Takashi; Fukata, Yuko; Fukata, Masaki; Matsumoto, Jumpei; Nishijo, Hisao; Takao, Keizo; Tanaka, Shinji; Okabe, Shigeo; Tabuchi, Katsuhiko; Uemura, Takeshi; Mishina, Masayoshi; Mori, Hisashi; Fukai, Shuya;
NATURE COMMUNICATIONS, 12(1), 1848, 2021年

Therapeutic Potential of Porcine Liver Decomposition Product: New Insights and Perspectives for Microglia-Mediated Neuroinflammation in Neurodegenerative Diseases
Tsukahara, Tamotsu; Haniu, Hisao; Uemura, Takeshi; Matsuda, Yoshikazu;
BIOMEDICINES, 8(11), 2020年11月

Oral administration of porcine liver decomposition product for 4 weeks enhances visual memory and delayed recall in healthy adults over 40 years of age: A randomized, double-blind, placebo-controlled study
Matsuda, Yoshikazu; Haniu, Hisao; Tsukahara, Tamotsu; Uemura, Takeshi; Inoue, Toshio; Sako, Ken-ichi; Kojima, Jun; Mori, Tatsuro; Sato, Kazusaburou;
EXPERIMENTAL GERONTOLOGY, 141, 2020年11月

Cellular Responses of Human Lymphatic Endothelial Cells to Carbon Nanomaterials
Sano, Mahoko; Izumiya, Makoto; Haniu, Hisao; Ueda, Katsuya; Konishi, Kosuke; Ishida, Haruka; Kuroda, Chika; Uemura, Takeshi; Aoki, Kaoru; Matsuda, Yoshikazu; Saito, Naoto;
Nanomaterials, 10(7), 2020年07月

Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro
Tsukahara Tamotsu;Haniu Hisao;Uemura Takeshi;Matsuda Yoshikazu
SCIENTIFIC REPORTS, 10(1), 2020年02月28日

Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells
Yoshida, Kazushige; Okamoto, Masanori; Sasaki, Jun; Kuroda, Chika; Ishida, Haruka; Ueda, Katsuya; Ideta, Hirokazu; Kamanaka, Takayuki; Sobajima, Atsushi; Takizawa, Takashi; Tanaka, Manabu; Aoki, Kaoru; Uemura, Takeshi; Kato, Hiroyuki; Haniu, Hisao; Saito, Naoto;
BMC CANCER, 20(1), 2020年

DNA repair protein RAD51 enhances the CRISPR/Cas9-mediated knock-in efficiency in brain neurons
Kurihara, Taiga; Kouyama-Suzuki, Emi; Satoga, Michiru; Li, Xue; Badawi, Moataz; Thiha; Baig, Deeba Noreen; Yanagawa, Toru; Uemura, Takeshi; Mori, Takuma; Tabuchi, Katsuhiko;
Biochemical and biophysical research communications, 524(3), 621-628, 2020年

Specific Neuroligin3-alpha Neurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus
Uchigashima, Motokazu; Konno, Kohtarou; Demchak, Emily; Cheung, Amy; Watanabe, Takuya; Keener, David G.; Abe, Manabu; Le, Timmy; Sakimura, Kenji; Sasaoka, Toshikuni; Uemura, Takeshi; Kawasawa, Yuka Imamura; Watanabe, Masahiko; Futai, Kensuke;
Elife, 9, 2020年

Carbon fibers for treatment of cancer metastasis in bone
Kamanaka, Takayuki; Haniu, Hisao; Tanaka, Manabu; Takizawa, Takashi; Aoki, Kaoru; Okamoto, Masanori; Sobajima, Atsushi; Yoshida, Kazushige; Ideta, Hirokazu; Mimura, Tetsuhiko; Ishida, Haruka; Ueda, Katsuya; Uemura, Takeshi; Kim, Jin Hee; Kim, Yoong Ahm; Kato, Hiroyuki; Saito, Naoto;
RSC Advances, 10(55), 33071-33079, 2020年

Deficiency of calcium/calmodulin-dependent serine protein kinase disrupts the excitatory-inhibitory balance of synapses by downregulating GluN2B (vol 24, pg 1079, 2019)
Mori, Takuma; Kasem, Enas A.; Suzuki-Kouyama, Emi; Cao, Xueshan; Li, Xue; Kurihara, Taiga; Uemura, Takeshi; Yanagawa, Toru; Tabuchi, Katsuhiko;
MOLECULAR PSYCHIATRY, 24(7), 1093-1093, 2019年07月

Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers
Yoshida, Kazushige; Okamoto, Masanori; Sasaki, Jun; Kuroda, Chika; Ishida, Haruka; Ueda, Katsuya; Okano, Satomi; Ideta, Hirokazu; Kamanaka, Takayuki; Sobajima, Atsushi; Takizawa, Takashi; Kito, Munehisa; Aoki, Kaoru; Uemura, Takeshi; Haniu, Hisao; Kato, Hiroyuki; Saito, Naoto;
OncoTargets and Therapy, 12, 2513-2518, 2019年

Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation
Goto-Ito S, Yamagata A, Sato Y, Uemura T, Shiroshima T, Maeda A, Imai A, Mori H, Yoshida T, Fukai
NATURE COMMUNICATIONS, 9, 269, 2018年, 査読有り
最終著者, 責任著者

MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells
Kawabata Galbraith K, Fujishima K, Mizuno H, Lee SJ, Uemura T, Sakimura K, Mishina M, Watanabe N, Kengaku M
Cell Rep, 24, 95-106, 2018年, 査読有り

Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction
Yamagata, Atsushi; Goto-Ito, Sakurako; Sato, Yusuke; Shiroshima, Tomoko; Maeda, Asami; Watanabe, Masahiko; Saitoh, Takashi; Maenaka, Katsumi; Terada, Tohru; Yoshida, Tomoyuki; Uemura, Takeshi; Fukai, Shuya;
NATURE COMMUNICATIONS, 9, 2018年
責任著者

In situ screening for postsynaptic cell adhesion molecules during synapse formation
Uemura T, Shiroshima T, Maeda A, Yasumura M, Shimada T, Fukata Y, Fukata M, Yoshida T
JOURNAL OF BIOCHEMISTRY, 162, 295-302, 2017年, 査読有り
筆頭著者, 責任著者

Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques
Uemura, Takeshi; Mori, Takuma; Kurihara, Taiga; Kawase, Shiori; Koike, Rie; Satoga, Michiru; Cao, Xueshan; Li, Xue; Yanagawa, Toru; Sakurai, Takayuki; Shindo, Takayuki; Tabuchi, Katsuhiko;
SCIENTIFIC REPORTS, 6, 2016年
筆頭著者, 責任著者

Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation
Yamagata, Atsushi; Yoshida, Tomoyuki; Sato, Yusuke; Goto-Ito, Sakurako; Uemura, Takeshi; Maeda, Asami; Shiroshima, Tomoko; Iwasawa-Okamoto, Shiho; Mori, Hisashi; Mishina, Masayoshi; Fukai, Shuya;
NATURE COMMUNICATIONS, 6, 2015年04月

Structure of Slitrk2-PTP delta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion
Yamagata, Atsushi; Sato, Yusuke; Goto-Ito, Sakurako; Uemura, Takeshi; Maeda, Asami; Shiroshima, Tomoko; Yoshida, Tomoyuki; Fukai, Shuya;
SCIENTIFIC REPORTS, 5, 2015年

Electron microscopy of primary cell cultures in solution and correlative optical microscopy using ASEM
Hirano, Kazumi; Kinoshita, Takaaki; Uemura, Takeshi; Motohashi, Hozumi; Watanabe, Yohei; Ebihara, Tatsuhiko; Nishiyama, Hidetoshi; Sato, Mari; Suga, Mitsuo; Maruyama, Yuusuke; Tsuji, Noriko M.; Yamamoto, Masayuki; Nishihara, Shoko; Sato, Chikara;
ULTRAMICROSCOPY, 143, 52-66, 2014年08月

Striatal dopamine D1 receptor is essential for contextual fear conditioning
Ikegami M, Uemura T, Kishioka A, Sakimura K, Mishina M
SCIENTIFIC REPORTS, 4, 3976, 2014年

IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours
Yasumura, Misato; Yoshida, Tomoyuki; Yamazaki, Maya; Abe, Manabu; Natsume, Rie; Kanno, Kouta; Uemura, Takeshi; Takao, Keizo; Sakimura, Kenji; Kikusui, Takefumi; Miyakawa, Tsuyoshi; Mishina, Masayoshi;
SCIENTIFIC REPORTS, 4, 2014年

Striatal dopamine D1 receptor is essential for contextual fear conditioning
Ikegami, Masaru; Uemura, Takeshi; Kishioka, Ayumi; Sakimura, Kenji; Mishina, Masayoshi;
SCIENTIFIC REPORTS, 4, 2014年

Synapse formation in the brain
Mishina M, Yoshida T, Yasumura M, Uemura T
Cortical Development, 282, 229－248, 2013年

Consolidation of auditory fear memories formed by weak unconditioned stimuli requires NMDA receptor activation and de novo protein synthesis in the striatum
Kishioka A, Uemura T, Fukushima F, Mishina M
Mol. Brain, 6, 17, 2013年

Molecular mechanism of parallel fiber-Purkinje cell synapse formation.
Masayoshi Mishina, Takeshi Uemura, Misato Yasumura and Tomoyuki Yoshida
Frontiers in Neural Circuits, 6(90), doi: 10.3389/fncir.2012.00090, 2012年, 査読有り

GluRδ2 Assembles Four Neurexins into Trans-Synaptic Triad to Trigger Synapse Formation
Lee SJ, Uemura T, Yoshida T, Mishina M
J Neurosci, 32(13), 4688-4701, 2012年

Interleukin-1 Receptor Accessory Protein organizes neuronal synaptogenesis as a cell adhesion molecule
Yoshida T, Shiroshima T, Lee SJ, Yasumura M, Uemura T, Chen X, Iwakura Y, Mishina M
J Neurosci, 32(8), 2588-2600, 2012年

Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of corticalneurons by interacting with neurexins through cerebellin precursor protein subtypes
Yasumura M, Yoshida T, Lee SJ, Uemura T, Joo JY, Mishina M
J Neurochem, 121(5), 705-716, 2012年

IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase δ
Yoshida T, Yasumura M, Uemura T, Lee SJ, Ra M, Taguchi R, Iwakura Y, Mishina M
J Neurosci, 31(88), 13485-13499, 2011年

Differential Interactions of Cerebellin Precursor Protein (Cbln) Subtypes and Neurexin Variants for Synapse Formation of Cortical Neurons
Joo JY, Lee SJ, Uemura T, Yoshida T, Yasumura M, Watanabe M, Mishina M
Biochem Biophys Res Commun, 406(4), 627-632, 2011年

Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum
Uemura T, Lee SJ, Yasumura M, Takeuchi T, Yoshida T, Ra M, Taguchi R, Sakimura K, Mishina M
Cell, 141(6), 1068-1079, 2010年

The amino-terminal domain of glutamate receptor δ2 triggers presynaptic differentiation
Uemura T, Mishina M
Biochem Biophys Res Commun, 377(4), 1315-1319, 2008年

Role of the internal Shank-binding segment of glutamate receptor δ2 in synaptic localization and cerebellar functions
Yasumura M, Uemura T, Yamasaki M, Sakimura K, Watanabe M, Mishina
Neurosci Lett, 433(2), 146-151, 2008年

Regulation of long-term depression and climbing fiber territory by glutamate receptor δ2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells
Uemura T, Kakizawa S, Yamasaki M, Sakimura K, WatanabeM, Iino M, Mishina M
J Neurosci, 27(44), 12096-12108, 2007年

Direct interaction of GluRδ2 with Shank scaffold proteins in cerebellar Purkinje cells
Uemura T, Mori H, Mishina M
Mol Cell Neurosci, 26(2), 330-341, 2004年

Molecular visualization of immunoglobulin switch region RNA/DNA complex byatomic force microscope
Mizuta R, Iwai K, Shigeno M, Mizuta M, Uemura T, Ushiki, T, Kitamura D
J Biol Chem, 278(7), 4431-4434, 2003年

Isolation and Characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain
Uemura T, Mori H, Mishina M
Biochem Biophys Res Commun, 296(2), 492-496, 2002年

実験医学増刊 32 10
深井周也, 植村 健, 吉田知之, シナプス形成を誘導する膜受容体の機能と構造
92－97 2014年

顕微鏡 49 1
植村 健;, 大気圧走査電子顕微鏡を用いたシナプス構造と分子局在の解析 (特集 大気圧走査電子顕微鏡(ASEM))
日本顕微鏡学会, 7-9 2014年

生物物理 53
植村健, シナプスオーガナイザーによるシナプス形成の制御機構
90－93 2013年
ISBN:https://doi.org/10.2142/biophys.53.090

細胞工学 30 2
植村健, 三品昌美, シナプス形成とグルタミン酸受容体δ２サブユニット
186-191 2011年

日本神経科学学会

日本薬理学会

Society of Neuroscience

脳神経回路網形成と機能制御の分子基盤とそれらの破綻が引き起こす神経発達障害の病態の解明