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桑原 宏一郎  クワハラ コウイチロウ

教員組織学術研究院(医学系)電話番号0263-37-3352
教育組織医学部 医学科 内科学第五FAX番号0263-37-2573
職名教授メールアドレスkkuwah@shinshu-u.ac.jp
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

プロフィール

研究分野
循環内科学、分子循環器病学、心血管内分泌代謝内科学
キーワード:心臓 , 心血管病 , ナトリウム利尿ペプチド
所属学会
所属学会
日本内科学会
日本循環器学会
日本内分泌学会
日本心血管内分泌代謝学会
日本心不全学会
国際心臓研究学会日本部会
American Heart Association
日本臨床分子医学会
日本肺高血圧・肺循環学会
日本糖尿病学会
日本心臓病学会
日本高血圧学会
日本心エコー図学会
日本生理学会
日本抗加齢医学会
日本不整脈心電学会
日本心臓リハビリテーション学会
European Society of Cardiology
学歴
出身大学院
2000 , 京都大学 , 大学院医学研究科

出身学校・専攻等(大学院を除く)
1991 , 京都大学 , 医学部

取得学位
医学博士 , 京都大学
受賞学術賞
2015 , 第3回日本心不全学会学術賞
2015 , 第18回日本臨床分子医学会学会賞
2013 , 第38回(2012年度)日本心臓財団 佐藤賞
2010 , 日本内分泌学会研究奨励賞
2009 , 日本心血管内分泌代謝学会高峰譲吉研究奨励賞
2005 , American Heart Association New Investigator Travel Award
2004 , 日本循環器学会 第14回八木賞
2001 , 日本心血管内分泌代謝学会若手研究者奨励賞
2001 , American Heart Association Melvin L. Marcus Young Investigator Award
2001 , 日本内分泌学会若手研究者奨励賞
2001 , 日本心脈管作動物質学会研究奨励賞
2000 , 日本循環器学会若手研究者奨励賞
1999 , 日本心不全学会若手研究者奨励賞
1999 , 日本臨床分子医学会研究奨励賞
研究職歴等
研究職歴
2016- , 信州大学医学部循環器内科学教室(内科学第五教室) 教授 
2013-2013 , 京都大学大学院医学研究科糖尿病・内分泌・栄養内科学 講師
2013-2013 , 京都大学大学院医学研究科循環器内科学 講師
2009-2013 , 京都大学大学院医学研究科内分泌代謝内科学 講師
2009-2009 , 京都大学大学院医学研究科内分泌代謝内科学 特定講師
2005-2009 , 京都大学大学院医学研究科内分泌代謝内科学 産学連携講師
2003-2005 , テキサス大学サウスウエスタン医学研究所分子生物学講座 フェロー
2000-2003 , 日本学術振興会特別研究員

研究活動業績

研究業績(著書・
発表論文等)
論文
Prognostic significance of diastolic blood pressure in patients with heart failure with preserved ejection fraction
HEART AND VESSELS,36(8):1159-1165 2021(Aug.)
Author:Fuchida, Aya; Suzuki, Sho; Motoki, Hirohiko; Kanzaki, Yusuke; Maruyama, Takuya; Hashizume, Naoto; Kozuka, Ayako; Yahikozawa, Kumiko; Kuwahara, Koichiro;
Keywords:HFpEF; DBP; Heart failure readmission; Diastolic blood pressure;


Safe and effective transvenous lead extraction for elderly patients utilizing non-laser and laser tools: a single-center experience in Japan
HEART AND VESSELS,36(6):882-889 2021(Jun.)
Author:Okada, Ayako; Tabata, Hiroaki; Shoda, Morio; Shoin, Wataru; Kobayashi, Hideki; Okano, Takahiro; Yoshie, Koji; Kato, Ken; Saigusa, Tatsuya; Ebisawa, Soichiro; Motoki, Hirohiko; Kuwahara, Koichiro;
Keywords:Older patients; Device extraction; Complication; Non-functional leads; Success rate;


Multisystem Inflammatory Syndrome in Children - A New Syndrome Complicated With Acute Heart Failure Following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection -
CIRCULATION JOURNAL,85(6):948-952 2021(Jun.)
Author:Uchida, Momoko; Kashima, Yuichiro; Mochizuki, Katsunori; Sakamoto, Hiroto; Mori, Kotaro; Ebisawa, Soichiro; Takeshige, Kanako; Nitta, Kenichi; Kuwahara, Koichiro; Imamura, Hiroshi;
Keywords:Multisystem inflammatory syndrome in children (MIS-C); Myocarditis; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2);


Serum cholinesterase as a prognostic biomarker for acute heart failure
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE,10(3):335-342 2021(Mar.)
Author:Shiba, Masayuki; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Seko, Yuta; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Yamashita, Yugo; Iguchi, Moritake; Nagao, Kazuya; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;
Keywords:Heart failure; Prognosis; Liver; Cholinesterase;


Searching for the Frequency of Cardiac Transthyretin Amyloidosis among Elderly Heart Failure Patients Noninvasively Using 99mTc-labeled Pyrophosphate Scintigraphy
信州医学雑誌,69(1):37-44 2021(Feb. 10)
Author:Miura, Takashi; Okina, Yoshiteru ; Mochidome, Tomoaki; Kobayashi, Takahiro; Kasai, Toshio; Ikeda, Uichi; Ezawa, Naoki; Sekijima, Yoshiki; Kuwahara, Koichiro


Prognostic usefulness of residual SYNTAX score combined with clinical factors for patients with acute coronary syndrome who underwent percutaneous coronary intervention from the SHINANO Registry
HEART AND VESSELS,36(2):170-179 2021(Feb.)
Author:Kashiwagi, Daisuke; Ebisawa, Soichiro; Yui, Hisanori; Maruyama, Shusaku; Nagae, Ayumu; Sakai, Takahiro; Kato, Tamon; Saigusa, Tatsuya; Okada, Ayako; Motoki, Hirohiko; Kuwahara, Koichiro;
Keywords:Percutaneous coronary intervention; Acute coronary syndrome; Multi-vessel coronary disease; Residual SYNTAX score;


Impact of nutritional index on long-term outcomes of elderly patients with coronary artery disease: sub-analysis of the SHINANO 5 year registry
HEART AND VESSELS,36(1):7-13 2021(Jan.)
Author:Maruyama, Shusaku; Ebisawa, Souichiro; Miura, Takashi; Yui, Hisanori; Kashiwagi, Daisuke; Nagae, Ayumu; Sakai, Takahiro; Kato, Tamon; Saigusa, Tatsuya; Okada, Ayako; Motoki, Hirohiko; Kuwahara, Koichiro;
Keywords:Coronary artery disease; Nutritional index; Prognosis;


Visualization of Spatially-Controlled Vasospasm by Sympathetic Nerve-Mediated ROCK Activation
AMERICAN JOURNAL OF PATHOLOGY,191(1):194-203 2021(Jan.)
Author:Imanishi, Ayako; Ichise, Hiroshi; Fan, Chuyun; Nakagawa, Yasuaki; Kuwahara, Koichiro; Sumiyama, Kenta; Matsuda, Michiyuki; Terai, Kenta;


"Alpha"-Looped Broken Pacemaker Lead Inside the Heart
CIRCULATION JOURNAL,85(1):77-77 2021(Jan.)
Author:Tabata, Hiroaki; Okada, Ayako; Kobayashi, Hideki; Shoin, Wataru; Okano, Takahiro; Yoshie, Koji; Motoki, Hirohiko; Shoda, Morio; Kuwahara, Koichiro;


Prognostic value of reduction in left atrial size during a follow-up of heart failure: an observational study
BMJ OPEN,11(2) 2021
Author:Shiba, Masayuki; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Seko, Yuta; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Yamashita, Yugo; Iguchi, Moritake; Nagao, Kazuya; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi; KCHF Study Investigators;
Keywords:heart failure; echocardiography; adult cardiology;


A case of transient ventricular pre-excitation associated with takotsubo cardiomyopathy
JOURNAL OF ELECTROCARDIOLOGY,65:73-75 2021
Author:Kobayashi, Hideki; Tabata, Hiroaki; Shoin, Wataru; Okano, Takahiro; Yoshie, Koji; Okada, Ayako; Shoda, Morio; Kuwahara, Koichiro;
Keywords:Takotsubo cardiomyopathy; Pre-excitation; Delta wave; Accessory pathway;


Protocol: Prospective observational study investigating the prevalence and clinical outcome of portopulmonary hypertension in Japanese patients with chronic liver disease
PLOS ONE,16(4) 2021
Author:Wakabayashi, Shun-ichi; Joshita, Satoru; Kimura, Kazuhiro; Motoki, Hirohiko; Kobayashi, Hiroyuki; Yamashita, Yuki; Sugiura, Ayumi; Yamazaki, Tomoo; Kuwahara, Koichiro; Umemura, Takeji;


Prognostic ability of mid-term worsening renal function after percutaneous coronary intervention: findings from the SHINANO registry
HEART AND VESSELS 2021
Author:Okina, Yoshiteru; Miura, Takashi; Senda, Keisuke; Taki, Minami; Kobayashi, Masanori; Kanai, Masafumi; Okuma, Yukari; Yanagisawa, Takashi; Hashizume, Naoto; Otagiri, Kyuhachi; Shoin, Kyoko; Watanabe, Noboru; Ebisawa, Soichiro; Karube, Kenichi; Nakajima, Hiroyuki; Saigusa, Tatsuya; Miyashita, Yusuke; Kashiwagi, Daisuke; Machida, Keisuke; Abe, Naoyuki; Tachibana, Takahiro; Kanzaki, Yusuke; Maruyama, Takuya; Nomi, Hidetomo; Sakai, Takahiro; Yui, Hisanori; Mochidome, Tomoaki; Kobayashi, Takahiro; Kasai, Toshio; Ikeda, Uichi; Kuwahara, Koichiro;
Keywords:Prognostic factor; Major adverse cardiovascular event (MACE); Renal insufficiency; Coronary vascular disease;


A decrease in tricuspid regurgitation pressure gradient associates with favorable outcome in patients with heart failure
ESC HEART FAILURE 2021
Author:Seko, Yuta; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Shiba, Masayuki; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Yamashita, Yugo; Iguchi, Moritake; Nagao, Kazuya; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi; KCHF Study Investigators;
Keywords:Tricuspid regurgitation pressure gradient; Heart failure; Mortality; Hospitalization; Prospective;


Admission systolic blood pressure as a prognostic predictor of acute decompensated heart failure: A report from the KCHF registry
PLOS ONE,16(7) 2021
Author:Kawase, Yuichi; Kato, Takao; Morimoto, Takeshi; Hata, Reo; Murai, Ryosuke; Tada, Takeshi; Katoh, Harumi; Kadota, Kazushige; Yamamoto, Erika; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Yoshikawa, Yusuke; Iguchi, Moritake; Nagao, Kazuya; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;


Lower In-Hospital Mortality With Beta-Blocker Use at Admission in Patients With Acute Decompensated Heart Failure
JOURNAL OF THE AMERICAN HEART ASSOCIATION,10(13) 2021
Author:Tamaki, Yodo; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Ozasa, Neiko; Yamamoto, Erika; Yoshikawa, Yusuke; Miyake, Makoto; Kondo, Hirokazu; Tamura, Toshihiro; Kitai, Takeshi; Iguchi, Moritake; Nagao, Kazuya; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Kawato, Mitsunori; Toyofuku, Mamoru; Sato, Yukihito; Kuwahara, Koichiro; Nakagawa, Yoshihisa; Kato, Takao; Kimura, Takeshi; KCHF Study Investigators;
Keywords:acute decompensated heart failure; beta-blocker; cohort study;


Association of the Prognosis of Ankle-brachial Index Improvement One Year Following Endovascular Therapy in Patients with Peripheral Artery Disease: Data from the I-PAD NAGANO Registry
INTERNAL MEDICINE,60(13):1999-2006 2021
Author:Senda, Keisuke; Miura, Takashi; Kato, Tamon; Kanzaki, Yusuke; Abe, Naoyuki; Yokota, Daisuke; Yanagisawa, Takashi; Okina, Yoshiteru; Wakabayashi, Tadamasa; Oyama, Yushi; Karube, Kenichi; Itagaki, Tadashi; Yoda, Hidetsugu; Shoin, Kyoko; Oguchi, Yasutaka; Aizawa, Katsuyuki; Suzuki, Chihiro; Kuwahara, Koichiro; I-PAD NAGANO Registry Investigator;
Keywords:peripheral artery disease; endovascular therapy; ankle-brachial index; major adverse cardiovascular events;


A case of transient ventricular pre-excitation associated with takotsubo cardiomyopathy
JOURNAL OF ELECTROCARDIOLOGY,65:73-75 2021
Author:Kobayashi, Hideki; Tabata, Hiroaki; Shoin, Wataru; Okano, Takahiro; Yoshie, Koji; Okada, Ayako; Shoda, Morio; Kuwahara, Koichiro;
Keywords:Takotsubo cardiomyopathy; Pre-excitation; Delta wave; Accessory pathway;


Absolute quantitative analysis of cardiac amyloidosis using SPECT/CT with Tc-99m-pyrophosphate
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS 2021
Author:Yanagisawa, Shin; Takahashi, Yusuke; Sasaki, Jun; Takasone, Ken; Yoshie, Koji; Koyama, Jun; Katoh, Nagaaki; Yazaki, Masahide; Kuwahara, Koichiro; Fujinaga, Yasunari; Sekijima, Yoshiki;


A decrease in tricuspid regurgitation pressure gradient associates with favorable outcome in patients with heart failure
ESC HEART FAILURE 2021
Author:Seko, Yuta; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Shiba, Masayuki; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Yamashita, Yugo; Iguchi, Moritake; Nagao, Kazuya; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi; KCHF Study Investigators;
Keywords:Tricuspid regurgitation pressure gradient; Heart failure; Mortality; Hospitalization; Prospective;


Body composition and mortality in patients undergoing endovascular treatment for peripheral artery disease
HEART AND VESSELS 2021
Author:Itagaki, Tadashi; Ebisawa, Soichiro; Otagiri, Kyuhachi; Kato, Tamon; Miura, Takashi; Kanzaki, Yusuke; Abe, Naoyuki; Yokota, Daisuke; Yanagisawa, Takashi; Senda, Keisuke; Okina, Yoshiteru; Wakabayashi, Tadamasa; Oyama, Yushi; Karube, Kenichi; Machida, Keisuke; Takeuchi, Takahiro; Saigusa, Tatsuya; Motoki, Hirohiko; Kitabayashi, Hiroshi; Kuwahara, Koichiro;
Keywords:Peripheral artery disease; Endovascular treatment; Mortality; Body composition;


Predictive Value of Abdominal Fat Distribution on Coronary Artery Disease Severity Stratified by Computed Tomography-Derived SYNTAX Score
AMERICAN JOURNAL OF CARDIOLOGY,150:32-39 2021
Author:Otagiri, Kyuhachi; Machida, Keisuke; Itagaki, Tadashi; Takeuchi, Takahiro; Tsujinaka, Yusuke; Yui, Hisanori; Nakamura, Chie; Sakai, Takahiro; Kato, Tamon; Saigusa, Tatsuya; Ebisawa, Soichiro; Motoki, Hirohiko; Kuwahara, Koichiro; Kitabayashi, Hiroshi;


Admission systolic blood pressure as a prognostic predictor of acute decompensated heart failure: A report from the KCHF registry
PLOS ONE,16(7) 2021
Author:Kawase, Yuichi; Kato, Takao; Morimoto, Takeshi; Hata, Reo; Murai, Ryosuke; Tada, Takeshi; Katoh, Harumi; Kadota, Kazushige; Yamamoto, Erika; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Yoshikawa, Yusuke; Iguchi, Moritake; Nagao, Kazuya; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;


Lower In-Hospital Mortality With Beta-Blocker Use at Admission in Patients With Acute Decompensated Heart Failure
JOURNAL OF THE AMERICAN HEART ASSOCIATION,10(13) 2021
Author:Tamaki, Yodo; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Ozasa, Neiko; Yamamoto, Erika; Yoshikawa, Yusuke; Miyake, Makoto; Kondo, Hirokazu; Tamura, Toshihiro; Kitai, Takeshi; Iguchi, Moritake; Nagao, Kazuya; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Kawato, Mitsunori; Toyofuku, Mamoru; Sato, Yukihito; Kuwahara, Koichiro; Nakagawa, Yoshihisa; Kato, Takao; Kimura, Takeshi; KCHF Study Investigators;
Keywords:acute decompensated heart failure; beta-blocker; cohort study;


心不全薬物治療の最前線
信州医学雑誌,68(6):347-355 2020(Dec. 10)
Author:桑原 宏一郎


Impact of changes in body mass index after percutaneous coronary intervention on long-term outcomes in patients with coronary artery disease
HEART AND VESSELS,35(12):1657-1663 2020(Dec.)
Author:Yui, Hisanori; Ebisawa, Soichiro; Miura, Takashi; Nakamura, Chie; Maruyama, Shusaku; Kashiwagi, Daisuke; Nagae, Ayumu; Sakai, Takahiro; Kato, Tamon; Saigusa, Tatsuya; Okada, Ayako; Motoki, Hirohiko; Kuwahara, Koichiro;
Keywords:Obesity paradox; Percutaneous coronary intervention; Coronary artery disease; Prognosis;


Sex differences in patients with acute decompensated heart failure in Japan: observation from the KCHF registry
ESC HEART FAILURE,7(5):2485-2493 2020(Oct.)
Author:Yamamoto, Erika; Kato, Takao; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Himura, Yoshihiro; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Kawato, Mitsunori; Seko, Yuta; Toyofuku, Mamoru; Furukawa, Yutaka; Nakagawa, Yoshihisa; Ando, Kenji; Kadota, Kazushige; Shizuta, Satoshi; Ono, Koh; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi; KCHF Study Investigators;
Keywords:Heart failure; Sex difference; Prognosis;


Rationale and design of the EMPYREAN study
ESC HEART FAILURE,7(5):3134-3141 2020(Oct.)
Author:Motoki, Hirohiko; Masuda, Izuru; Yasuno, Shinji; Oba, Koji; Shoin, Wataru; Usami, Satoru; Saito, Yoshihiko; Waki, Masako; Komatsu, Mitsuhisa; Ueshima, Kenji; Nakagawa, Yasuaki; Son, Cheol; Yonemitsu, Shin; Hiramitsu, Shinya; Konda, Manako; Onishi, Katsuya; Kuwahara, Koichiro;
Keywords:Diabetes mellitus; SGLT2 inhibitors; Heart rate variability;


Prognostic impact of mineralocorticoid receptor antagonist in patients with heart failure with preserved ejection fraction
ESC HEART FAILURE,7(5):2752-2761 2020(Oct.)
Author:Suzuki, Sho; Motoki, Hirohiko; Kanzaki, Yusuke; Maruyama, Takuya; Hashizume, Naoto; Kozuka, Ayako; Yahikozawa, Kumiko; Kuwahara, Koichiro;
Keywords:Mineralocorticoid receptor antagonist; MRA; Spironolactone; Heart failure with preserved ejection fraction; HFpEF; Prognosis;


Prognostic significance of resting heart rate in atrial fibrillation patients with heart failure with reduced ejection fraction
HEART AND VESSELS,35(8):1109-1115 2020(Aug.)
Author:Suzuki, Sho; Motoki, Hirohiko; Kanzaki, Yusuke; Maruyama, Takuya; Hashizume, Naoto; Kozuka, Ayako; Yahikozawa, Kumiko; Kuwahara, Koichiro;
Keywords:Heart rate; Atrial fibrillation; Heart failure with reduced ejection fraction; Prognosis;


Sodium-Glucose Cotransporter-2 inhibitors are potential therapeutic agents for treatment of non-diabetic heart failure patients
JOURNAL OF CARDIOLOGY,76(2):123-131 2020(Aug.)
Author:Nakagawa, Yasuaki; Kuwahara, Koichiro;
Keywords:Sodium-glucose cotransporter-2 inhibitor; Empagliflozin; Canagliflozin; Dapagliflozin; Heart failure;


Prognostic Impact of Cardio-renal-anemia Syndrome in Patients at Risk for Heart Failure from the IMPACT-ABI study
信州医学雑誌,68(3):139-147 2020(Jun. 10)
Author:Shoin W, Ebisawa S, Saigusa T, Sakai T, Oguchi Y, Okada A, Motoki H, Kuwahara K


Impact of Ambulation Status in Patients with End-stage Renal Disease on Hemodialysis due to Diabetic Nephropathy : The PREDICT Study
信州医学雑誌,68(3):131-138 2020(Jun. 10)
Author:Kato T, Miyashita Y, Sone H, Mizukami T, Kanno Y, Oguchi T, Yokota D, Shiotsuki N, Mizukami E, Terashima M, Aruga M, Yui H, Maruyama S, Kobayashi H, Kashiwagi D, Nagae A, Sakai T, Saigusa T, Ebisawa S, Okada A, Motoki H, Kuwahara K


A Predictive Model for 6-Month Mortality in Elderly Patients with Heart Failure
INTERNATIONAL HEART JOURNAL,61(2):325-331 2020(Mar.)
Author:Suzuki, Sho; Motoki, Hirohiko; Kanzaki, Yusuke; Maruyama, Takuya; Hashizume, Naoto; Kozuka, Ayako; Yahikozawa, Kumiko; Kuwahara, Koichiro;
Keywords:Risk score; Short-term; Death;


Risk factors and clinical outcomes of functional decline during hospitalisation in very old patients with acute decompensated heart failure: an observational study
BMJ OPEN,10(2) 2020(Feb.)
Author:Yaku, Hidenori; Kato, Takao; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Kato, Masashi; Ikeda, Tomoyuki; Furukawa, Yutaka; Nakagawa, Yoshihisa; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;


A Statement on the Appropriate Administration of Tafamidis in Patients With Transthyretin Cardiac Amyloidosis
CIRCULATION JOURNAL,84(1):15-17 2020(Jan.)
Author:Endo, Jin; Sano, Motoaki; Izumiya, Yasuhiro; Tsujita, Kenichi; Nakamura, Kazufumi; Tahara, Nobuhiro; Kuwahara, Koichiro; Inomata, Takayuki; Ueda, Mitsuharu; Sekijima, Yoshiki; Ando, Yukio; Tsutsui, Hiroyuki; Isobe, Mitsuaki; Fukuda, Keiichi;
Keywords:Amyloid; ATTR cardiac amyloidosis; Japanese Circulation Society; Japanese Ministry of Health, Labour and Welfare (JMHLW); Tafamidis;


C-reactive protein at discharge and 1-year mortality in hospitalised patients with acute decompensated heart failure: an observational study
BMJ OPEN,10(12) 2020
Author:Nishimoto, Yuji; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Su, Kanae; Kawato, Mitsunori; Seko, Yuta; Inoko, Moriaki; Toyofuku, Mamoru; Furukawa, Yutaka; Nakagawa, Yoshihisa; Ando, Kenji; Kadota, Kazushige; Shizuta, Satoshi; Ono, Koh; Kuwahara, Koichiro; Ozasa, Neiko; Sato, Yukihito; Kimura, Takeshi;
Keywords:heart failure; ischaemic heart disease; adult cardiology;


Association with Controlling Nutritional Status (CONUT) Score and In-hospital Mortality and Infection in Acute Heart Failure
SCIENTIFIC REPORTS,10(1) 2020
Author:Kato, Takao; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Su, Kanae; Kawato, Mitsunori; Seko, Yuta; Inoko, Moriaki; Toyofuku, Mamoru; Furukawa, Yutaka; Nakagawa, Yoshihisa; Ando, Kenji; Kadota, Kazushige; Shizuta, Satoshi; Ono, Koh; Sato, Yukihito; Kuwahara, Koichiro; Ozasa, Neiko; Kimura, Takeshi;


Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo
SCIENTIFIC REPORTS,10(1) 2020
Author:Ichimura, Hajime; Kadota, Shin; Kashihara, Toshihide; Yamada, Mitsuhiko; Ito, Kuniaki; Kobayashi, Hideki; Tanaka, Yuki; Shiba, Naoko; Chuma, Shinichiro; Tohyama, Shugo; Seto, Tatsuichiro; Okada, Kenji; Kuwahara, Koichiro; Shiba, Yuji;


Increased Ga(o)Expression Regulated by NRSF Plays a Key Role in the Development of Heart Failure Through the Impairment of Ca2+ Homeostasis
CIRCULATION RESEARCH,127 2020
Author:Inazumi, Hideaki; Nakagawa, Yasuaki; Moriuchi, Kenji; Kuwahara, Koichiro;


Impact of left ventricular ejection fraction on the effect of renin-angiotensin system blockers after an episode of acute heart failure: From the KCHF Registry
PLOS ONE,15(9) 2020
Author:Yoshikawa, Yusuke; Tamaki, Yodo; Morimoto, Takeshi; Yaku, Hidenori; Yamamoto, Erika; Inuzuka, Yasutaka; Ozasa, Neiko; Kitai, Takeshi; Nagao, Kazuya; Sato, Yukihito; Kondo, Hirokazu; Tamura, Toshihiro; Nakagawa, Yoshihisa; Kuwahara, Koichiro; Kato, Takao; Kimura, Takeshi;


Association between body mass index and prognosis of patients hospitalized with heart failure
SCIENTIFIC REPORTS,10(1) 2020
Author:Seko, Yuta; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Shiba, Masayuki; Yamamoto, Erika; Yoshikawa, Yusuke; Yamashita, Yugo; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;


Cardio-renal and cardio-hepatic interactions predict cardiovascular events in elderly patients with heart failure
PLOS ONE,15(10) 2020
Author:Okano, Takahiro; Motoki, Hirohiko; Minamisawa, Masatoshi; Kimura, Kazuhiro; Kanai, Masafumi; Yoshie, Koji; Higuchi, Satoko; Saigusa, Tatsuya; Ebisawa, Soichiro; Okada, Ayako; Shoda, Morio; Kuwahara, Koichiro;


Association of an increase in serum albumin levels with positive 1-year outcomes in acute decompensated heart failure: A cohort study
PLOS ONE,15(12) 2020
Author:Kato, Takao; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Kawato, Mitsunori; Seko, Yuta; Shiba, Masayuki; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;


心不全薬物治療の最前線
信州医学雑誌,68(6):349-355 2020
Author:桑原 宏一郎
Keywords:心不全;神経体液性因子;薬物治療


C-reactive protein at discharge and 1-year mortality in hospitalised patients with acute decompensated heart failure: an observational study
BMJ OPEN,10(12) 2020
Author:Nishimoto, Yuji; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Su, Kanae; Kawato, Mitsunori; Seko, Yuta; Inoko, Moriaki; Toyofuku, Mamoru; Furukawa, Yutaka; Nakagawa, Yoshihisa; Ando, Kenji; Kadota, Kazushige; Shizuta, Satoshi; Ono, Koh; Kuwahara, Koichiro; Ozasa, Neiko; Sato, Yukihito; Kimura, Takeshi;
Keywords:heart failure; ischaemic heart disease; adult cardiology;


Association with Controlling Nutritional Status (CONUT) Score and In-hospital Mortality and Infection in Acute Heart Failure
SCIENTIFIC REPORTS,10(1) 2020
Author:Kato, Takao; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Su, Kanae; Kawato, Mitsunori; Seko, Yuta; Inoko, Moriaki; Toyofuku, Mamoru; Furukawa, Yutaka; Nakagawa, Yoshihisa; Ando, Kenji; Kadota, Kazushige; Shizuta, Satoshi; Ono, Koh; Sato, Yukihito; Kuwahara, Koichiro; Ozasa, Neiko; Kimura, Takeshi;


MRTF-A promotes angiotensin II-induced inflammatory response and aortic dissection in mice
PLOS ONE,15(3) 2020
Author:Ito, Sohei; Hashimoto, Yohei; Majima, Ryohei; Nakao, Eichi; Aoki, Hiroki; Nishihara, Michihide; Ohno-Urabe, Satoko; Furusho, Aya; Hirakata, Saki; Nishida, Norifumi; Hayashi, Makiko; Kuwahara, Koichiro; Fukumoto, Yoshihiro;


Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo
SCIENTIFIC REPORTS,10(1) 2020
Author:Ichimura, Hajime; Kadota, Shin; Kashihara, Toshihide; Yamada, Mitsuhiko; Ito, Kuniaki; Kobayashi, Hideki; Tanaka, Yuki; Shiba, Naoko; Chuma, Shinichiro; Tohyama, Shugo; Seto, Tatsuichiro; Okada, Kenji; Kuwahara, Koichiro; Shiba, Yuji;


Increased Ga(o)Expression Regulated by NRSF Plays a Key Role in the Development of Heart Failure Through the Impairment of Ca2+ Homeostasis
CIRCULATION RESEARCH,127 2020
Author:Inazumi, Hideaki; Nakagawa, Yasuaki; Moriuchi, Kenji; Kuwahara, Koichiro;


Impact of left ventricular ejection fraction on the effect of renin-angiotensin system blockers after an episode of acute heart failure: From the KCHF Registry
PLOS ONE,15(9) 2020
Author:Yoshikawa, Yusuke; Tamaki, Yodo; Morimoto, Takeshi; Yaku, Hidenori; Yamamoto, Erika; Inuzuka, Yasutaka; Ozasa, Neiko; Kitai, Takeshi; Nagao, Kazuya; Sato, Yukihito; Kondo, Hirokazu; Tamura, Toshihiro; Nakagawa, Yoshihisa; Kuwahara, Koichiro; Kato, Takao; Kimura, Takeshi;


Association between body mass index and prognosis of patients hospitalized with heart failure
SCIENTIFIC REPORTS,10(1) 2020
Author:Seko, Yuta; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Shiba, Masayuki; Yamamoto, Erika; Yoshikawa, Yusuke; Yamashita, Yugo; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;


Cardio-renal and cardio-hepatic interactions predict cardiovascular events in elderly patients with heart failure
PLOS ONE,15(10) 2020
Author:Okano, Takahiro; Motoki, Hirohiko; Minamisawa, Masatoshi; Kimura, Kazuhiro; Kanai, Masafumi; Yoshie, Koji; Higuchi, Satoko; Saigusa, Tatsuya; Ebisawa, Soichiro; Okada, Ayako; Shoda, Morio; Kuwahara, Koichiro;


Association of an increase in serum albumin levels with positive 1-year outcomes in acute decompensated heart failure: A cohort study
PLOS ONE,15(12) 2020
Author:Kato, Takao; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Kawato, Mitsunori; Seko, Yuta; Shiba, Masayuki; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;


心不全薬物治療の最前線
信州医学雑誌,68(6):349-355 2020
Author:桑原 宏一郎
Keywords:心不全;神経体液性因子;薬物治療


Prognostic significance of high-sensitivity cardiac troponin in patients with heart failure with preserved ejection fraction
HEART AND VESSELS,34(10):1650-1656 2019(Oct.)
Author:Suzuki, Sho; Motoki, Hirohiko; Minamisawa, Masatoshi; Okuma, Yukari; Shoin, Wataru; Okano, Takahiro; Kimura, Kazuhiro; Ebisawa, Soichiro; Okada, Ayako; Kuwahara, Koichiro;
Keywords:Heart failure with preserved ejection fraction; High-sensitivity troponin T; Prognosis;


Ankle-Brachial Index as a Prognostic Indicator in Patients with Atrial Fibrillation -A Subanalysis of the IMPACT-ABI Study
信州医学雑誌,67(3):197-204 2019(Jun. 10)
Author:Oguchi Y, Saigusa T, Ebisawa S, Okada A, Motoki H, Kuwahara K


Impact of inpatient cardiac rehabilitation on Barthel Index score and prognosis in patients with acute decompensated heart failure
INTERNATIONAL JOURNAL OF CARDIOLOGY,293:125-130 2019
Author:Motoki, Hirohiko; Nishimura, Musashi; Kanai, Masafumi; Kimura, Kazuhiro; Minamisawa, Masatoshi; Yamamoto, Shuhei; Saigusa, Tatsuya; Ebisawa, Soichiro; Okada, Ayako; Kuwahara, Koichiro;


心房細動アブレーション:肺静脈隔離術 (Pulmonary vein isolation : PVI)
信州医学雑誌,67(4):259-262 2019
Author:岡田 綾子;田畑 裕章;酒井 貴弘;三枝 達也;海老澤 聡一朗;元木 博彦;小山 潤;庄田 守男;桑原 宏一郎


⼼筋梗塞後のマウス心臓におけるミトコンドリアーアクチン相互作⽤の病態生理学的意義
日本薬理学会年会要旨集,92:2-YIA-21 2019
Author:田中 智弘;安田 智;佐藤 陽治;桑原 宏一郎;熊谷 嘉人;赤池 孝章;井手 友美;王子田 彰夫;森 泰生;西田 基宏;西村 明幸;下田 翔;島内 司;外山 隆;北島 直幸;石川 達也;進藤 直哉;沼賀-富田 拓郎
Abstract:

Defective mitochondrial dynamics through aberrant interactions between mitochondria and actin cytoskeleton is increasingly recognized as a key determinant of cardiac fragility after myocardial infarction (MI). Dynamin-related protein 1 (Drp1), a mitochondrial fission–accelerating factor, is activated locally at the fission site through interactions with actin. Here, we report that the actin-binding protein filamin A acted as a guanine nucleotide exchange factor for Drp1 and mediated mitochondrial fission–associated myocardial senescence in mice after MI.Pharmacological perturbation of the Drp1–filamin A interaction by cilnidipine suppressed mitochondrial hyperfission–associated myocardial senescence and heart failure after MI. These data demonstrate that Drp1 association with filamin, and the actin cytoskeleton, contributes to cardiac fragility after MI and suggests a potential repurposing of cilnidipine.




利尿薬の新しい展開
心臓,51(4):383-387 2019
Author:桑原 宏一郎


心房細動アブレーション:肺静脈隔離術 (Pulmonary vein isolation : PVI)
信州医学雑誌,67(4):259-262 2019
Author:岡田 綾子;田畑 裕章;酒井 貴弘;三枝 達也;海老澤 聡一朗;元木 博彦;小山 潤;庄田 守男;桑原 宏一郎


⼼筋梗塞後のマウス心臓におけるミトコンドリアーアクチン相互作⽤の病態生理学的意義
日本薬理学会年会要旨集,92:2-YIA-21 2019
Author:田中 智弘;安田 智;佐藤 陽治;桑原 宏一郎;熊谷 嘉人;赤池 孝章;井手 友美;王子田 彰夫;森 泰生;西田 基宏;西村 明幸;下田 翔;島内 司;外山 隆;北島 直幸;石川 達也;進藤 直哉;沼賀-富田 拓郎
Abstract:

Defective mitochondrial dynamics through aberrant interactions between mitochondria and actin cytoskeleton is increasingly recognized as a key determinant of cardiac fragility after myocardial infarction (MI). Dynamin-related protein 1 (Drp1), a mitochondrial fission–accelerating factor, is activated locally at the fission site through interactions with actin. Here, we report that the actin-binding protein filamin A acted as a guanine nucleotide exchange factor for Drp1 and mediated mitochondrial fission–associated myocardial senescence in mice after MI.Pharmacological perturbation of the Drp1–filamin A interaction by cilnidipine suppressed mitochondrial hyperfission–associated myocardial senescence and heart failure after MI. These data demonstrate that Drp1 association with filamin, and the actin cytoskeleton, contributes to cardiac fragility after MI and suggests a potential repurposing of cilnidipine.




利尿薬の新しい展開
心臓,51(4):383-387 2019
Author:桑原 宏一郎


Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia
J Physiol Sci,69(4):653-660 2019
Author:Oshita K, Kozasa Y, Nakagawa Y, Kuwabara Y, Kuwahara K, Nakagawa T, Nakashima N, Hiraki T, Takano M


Association of Mineralocorticoid Receptor Antagonist Use With All-Cause Mortality and Hospital Readmission in Older Adults With Acute Decompensated Heart Failure
JAMA Netw Open,2(6):e195892 2019
Author:Yaku H, Kato T, Morimoto T, Inuzuka Y, Tamaki Y, Ozasa N, Yamamoto E, Yoshikawa Y, Kitai T, Taniguchi R, Iguchi M, Kato M, Takahashi M, Jinnai T, Ikeda T, Nagao K, Kawai T, Komasa A, Nishikawa R, Kawase Y, Morinaga T, Toyofuku M, Seko Y, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Shizuta S, Ono K, Sato Y, Kuwahara K, Kimura T; KCHF Study Investigators


Utility of copeptin for predicting long-term clinical outcomes inpatients with heart failure
J Cardiol,73(5):379-385 2019
Author:Yoshikawa Y, Shiomi H, Kuwahara K, Sowa N, Yaku H, Yamashita Y, Tazaki J, Imai M, Kato T, Saito N, Shizuta S, Ono K, Kimura T


Impact of Therapeutic Angiogenesis Using Autologous Bone Marrow-Derived Mononuclear Cells Implantation in Critical Limb Ischemia With Scleroderma - Subanalysis of the Long-Term Clinical Outcomes Survey
Circ J,83(3):662-671 2019
Author:Shoji K, Yanishi K, Yoshimi R, Hamada N, Kondo K, Fujimoto K, Nakajima H, Kuwahara K, Higashi Y, Fukumoto Y, Murohara T, Matoba S; TACT Follow up Study Investigators


Comparison of Long-Acting and Short Acting Loop Diuretics in the Treatment of Heart Failure With Preserved Ejection Fraction
Circ Rep,1:137-141 2019
Author:Suzuki S, Motoki H, Kanzaki Y, Maruyama T, Hashizume N, Kozuka A, Yahikozawa K, Kuwahara K


Biopsy detection and clinical management of acute lymphocytic myocarditis in pregnancy
J Cardiol Cases,20(5):164-167 2019
Author:Sunohara D, Motoki H, Saigusa T, Ebisawa S, Okada A, Ando H, Sato M, Kuwahara K


Successful inferior vena cava filter removal using pacemaker lead extraction methods
J Cardiol Cases,19(4):129-132 2019
Author:Itagaki T, Okada A, Tabata H, Shoin W, Kobayashi H, Okano T, Oguchi Y, Mochidome T, Saigusa T, Ebisawa S, Motoki H, Shoda M, Kuwahara K


Role of echocardiography in assessing cardiac amyloidosis : a systematic review
J Echocardiogr ,17(2):64-75 2019
Author:Koyama J, Minamisawa M, Sekijima Y, Kuwahara K, Katsuyama T, Maruyama K


Comparison of leg loader and treadmill exercise for evaluating patients with peripheral artery disease
Heart Vessels,34(4):590-596 2019
Author:Ueki Y, Miura T, Mochidome T, Senda K, Ebisawa S, Saigusa T, Motoki H, Okada A, Koyama J, Kuwahara K


MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages
,133:26-35 2019
Author:An J, Naruse TK, Hinohara K, Soejima Y, Sawabe M, Nakagawa Y, Kuwahara K, Kimura A


Impact of inpatient cardiac rehabilitation on Barthel Index score and prognosis in patients with acute decompensated heart failure
Int J Cardiol,293:125-130 2019
Author:Motoki H, Nishimura M, Kanai M, Kimura K, Minamisawa M, Yamamoto S, Saigusa T, Ebisawa S, Okada A, Kuwahara K


Prognostic significance of high‑sensitivity cardiac troponin in patients with heart failure with preserved ejection fraction
Heart Vessels,34(10):1650-1656 2019
Author:Suzuki S, Motoki H, Minamisawa M, Okuma Y, Shoin W, Okano T, Kimura K, Ebisawa S, Okada A, Kuwahara K


Association between reactive hyperemia peripheral arterial tonometry index and atrial fibrillation recurrence after catheter ablation
Int J Cardiol Heart Vasc,24:100385 2019
Author:Kobayashi H, Okada A, Tabata H, Shoin W, Okano T, Yoshie K, Oguchi Y, Kato K, Shoda M, Kuwahara K


Wire perforation causing cardiopulmonary arrest during radiofrequency hot balloon ablation for pulmonary vein isolation
J Cardiol Cases,19(5):169-172 2019
Author:Okano T, Okada A, Tabata H, Kobayashi H, Shoin W, Yoshie K, Oguchi Y, Shoda M, Kuwahara K


A case of thrombolytic therapy with recombinant tissue plasminogen activator for mechanical valve thrombosis at 9 weeks of pregnancy in a Japanese woman
J Cardiol Cases,19(1):15-18 2019
Author:Komatsu T, Motoki H, Kimura K, Saigusa T, Ebisawa S, Yokokawa Y, Ando H, Ichino T, Kuwahara K.


Atrial and brain natriuretic peptides: Hormones secreted from the heart
Peptides,111:18-25 2019
Author:Nakagawa Y, Nishikimi T, Kuwahara K


Epicardial Stone: Unfamiliar Calcified Mass at the Site of a Left Ventricular Old Myocardial Infarction
Circ J,83(9):262 2019
Author:Tabata H, Motoki H, Sakai T, Okada A, Kuwahara K


Establishment of a Healthcare System for Patients with Adult Congenital Heart Disease in Collaboration with Children’s Hospitals: The Nagano Model
Circ J,83(2):424-431 2019
Author:Motoki H, Yasukochi S, Takigiku K, Takei K, Okamura T, Kimura K, Minamisawa M, Okada A, Saigusa T, Ebisawa S, Seto T, Shoda M, Okada K, Kuwahara K


心房細動アブレーション:肺静脈隔離術 (Pulmonary vein isolation : PVI)
信州医学雑誌,67(4):259-262 2019
Author:岡田 綾子;田畑 裕章;酒井 貴弘;三枝 達也;海老澤 聡一朗;元木 博彦;小山 潤;庄田 守男;桑原 宏一郎


⼼筋梗塞後のマウス心臓におけるミトコンドリアーアクチン相互作⽤の病態生理学的意義
日本薬理学会年会要旨集,92:2-YIA-21 2019
Author:田中 智弘;安田 智;佐藤 陽治;桑原 宏一郎;熊谷 嘉人;赤池 孝章;井手 友美;王子田 彰夫;森 泰生;西田 基宏;西村 明幸;下田 翔;島内 司;外山 隆;北島 直幸;石川 達也;進藤 直哉;沼賀-富田 拓郎


利尿薬の新しい展開
心臓,51(4):383-387 2019
Author:桑原 宏一郎


Predictive Value of Underweight Status for Patients With Peripheral Artery Disease With Claudication
ANGIOLOGY,69(6):513-522 2018(Jul.)
Author:Senda, Keisuke; Miura, Takashi; Minamisawa, Masatoshi; Ueki, Yasushi; Mochidome, Tomoaki; Nomi, Hidetomo; Shoin, Wataru; Higuchi, Satoko; Oguchi, Yasutaka; Nishimura, Hitoshi; Saigusa, Tatsuya; Ebisawa, Soichiro; Motoki, Hirohiko; Izawa, Atsushi; Koyama, Jun; Ikeda, Uichi; Kuwahara, Koichiro;


Geriatric Nutritional Risk Index Predicts Cardiovascular Events in Patients at Risk for Heart Failure
CIRCULATION JOURNAL,82(6):1614-+ 2018(Jun.)
Author:Minamisawa, Masatoshi; Miura, Takashi; Motoki, Hirohiko; Ueki, Yasushi; Nishimura, Hitoshi; Shimizu, Kunihiko; Shoin, Wataru; Harada, Mikiko; Mochidome, Tomoaki; Senda, Keisuke; Yoshie, Koji; Oguchi, Yasutaka; Hashizume, Naoto; Abe, Naoyuki; Saigusa, Tatsuya; Ebisawa, Soichiro; Izawa, Atsushi; Koyama, Jun; Ikeda, Uichi; Kuwahara, Koichiro;


Macro-pro-B-type natriuretic peptide (proBNP) and hidden macro-N-terminal proBNP: Case report
CLINICAL BIOCHEMISTRY,52:148-152 2018(Feb.)
Author:Nakagawa, Yasuaki; Nishikimi, Toshio; Sakai, Hiroshi; Ohno, Seiko; Kinoshita, Hideyuki; Inazumi, Hideaki; Moriuchi, Kenji; Kuwahara, Koichiro; Horie, Minoru; Kimura, Takeshi;


内科学第五教室
信州医学雑誌,66(3):226-226 2018
Author:桑原 宏一郎


深部静脈血栓症を疑って施行された下肢静脈超音波検査の有病率に関する検討
脈管学,58(9):145-149 2018
Author:山崎 佐枝子;元木 博彦;桑原 宏一郎;三浦 崇;千田 啓介;酒井 貴弘;小口 泰尚;加藤 太門;三枝 達也;海老澤 聡一朗;岡田 綾子
Abstract:

深部静脈血栓症(DVT)が疑われ,当院生理検査室に依頼された下肢静脈超音波検査108件のうち,新規検査80件を対象とした。患者背景,危険因子,DVTの有病率などを後ろ向きに調査した。DVTは29例(36.2%)に認められた。DVTのスクリーニングにDダイマーが推奨されているが,偽陽性が多いため,検査前確率を上げるために他検査との組み合わせの検討が求められる。


Keywords:venous thromboembolism;deep vein thrombosis;ultrasonography


内科学第五教室
信州医学雑誌,66(3):226-226 2018
Author:桑原 宏一郎


深部静脈血栓症を疑って施行された下肢静脈超音波検査の有病率に関する検討
脈管学,58(9):145-149 2018
Author:山崎 佐枝子;元木 博彦;桑原 宏一郎;三浦 崇;千田 啓介;酒井 貴弘;小口 泰尚;加藤 太門;三枝 達也;海老澤 聡一朗;岡田 綾子
Abstract:

深部静脈血栓症(DVT)が疑われ,当院生理検査室に依頼された下肢静脈超音波検査108件のうち,新規検査80件を対象とした。患者背景,危険因子,DVTの有病率などを後ろ向きに調査した。DVTは29例(36.2%)に認められた。DVTのスクリーニングにDダイマーが推奨されているが,偽陽性が多いため,検査前確率を上げるために他検査との組み合わせの検討が求められる。


Keywords:venous thromboembolism;deep vein thrombosis;ultrasonography


内科学第五教室
信州医学雑誌,66(3):226-226 2018
Author:桑原 宏一郎


深部静脈血栓症を疑って施行された下肢静脈超音波検査の有病率に関する検討
脈管学,58(9):145-149 2018
Author:山崎 佐枝子;元木 博彦;桑原 宏一郎;三浦 崇;千田 啓介;酒井 貴弘;小口 泰尚;加藤 太門;三枝 達也;海老澤 聡一朗;岡田 綾子
Keywords:venous thromboembolism;deep vein thrombosis;ultrasonography


Cross-sectional study of the association between day-to-day home blood pressure variability and visceral fat area measured using the dual impedance method
PLoS One,13(11):e0206945 2018
Author:Kuwabara J, Kuwahara K, Kuwabara Y, Yasuno S, Nakagawa Y, Ueshima K, Kimura T


Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence
Sci Signal,11(556):eaat5185 2018
Author:Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M


Demographics, Management, and In-Hospital Outcome of Hospitalized Acute Heart Failure Syndrome Patients in Contemporary Real Clinical Practice in Japan - Observations From the Prospective, Multicenter Kyoto Congestive Heart Failure (KCHF) Registry
Circ J,82(11):2811-2819 2018
Author:Yaku H, Ozasa N, Morimoto T, Inuzuka Y, Tamaki Y, Yamamoto E, Yoshikawa Y, Kitai T, Taniguchi R, Iguchi M, Kato M, Takahashi M, Jinnai T, Ikeda T, Nagao K, Kawai T, Komasa A, Nishikawa R, Kawase Y, Morinaga T, Su K, Kawato M, Sasaki K, Toyofuku M, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Shizuta S, Ono K, Sato Y, Kuwahara K, Kato T, Kimura T, on behalf of the KCHF Study Investigators


Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
Open Heart,5:e000896 2018
Author:Minamisawa M, Koyama J, Kozuka A, Miura T, Saigusa T, Ebisawa S, Motoki H, Okada A, Ikeda U, Kuwahara K


T-wave alternans in a case with systemic lupus erythematosus-related myocarditis
J Cardiol Cases,18(4):119-122 2018
Author:Harada M, Motoki H, Kashima Y, Nakamura C, Hashizume N, Kishida D, Imamura H, Kuwahara K


Cutting Edge of Brain Natriuretic Peptide (BNP) Research - The Diversity of BNP Immunoreactivity and Its Clinical Relevance
Circ J,82(10):2455-2461 2018
Author:Kuwahara K, Nakagawa Y, Nishikimi T


Drug-Eluting Versus Bare-Metal Stent Implantation with or without Cilostazol in the Treatment of the Superficial Femoral Artery
Circ Cardiovasc Interv,11(8):e006564 2018
Author:Miura T, Miyashita Y, Soga Y, Hozawa K, Doijiri T, Ikeda U, Kuwahara K on behalf of the DEBATE in SFA investigators


Single-center experience with percutaneous lead extraction of cardiac implantable electric devices
JOURNAL OF CARDIOLOGY,71(1-2):192-196 2018
Author:Okada, Ayako; Shoda, Morio; Tabata, Hiroaki; Shoin, Wataru; Kobayashi, Hideki; Okano, Takahiro; Yoshie, Koji; Oguchi, Yasutaka; Takeuchi, Takahiro; Kato, Ken; Kuwahara, Koichiro;


CHARACTERISTIC AND CLINICAL OUTCOMES IN PATIENTS WITH LEFT VENTRICULAR NONCOMPACTION IN ADULTS: A NATIONWIDE SURVEY IN JAPAN
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,71(11):714-714 2018
Author:Minamisawa, Masatoshi; Koyama, Jun; Kuwahara, Koichiro; Ikeda, Uichi;


Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death
PLOS ONE,13(3) 2018
Author:Fujii, Toshihito; Hirota, Keisho; Yasoda, Akihiro; Takizawa, Akiko; Morozumi, Naomi; Nakamura, Ryuichi; Yotsumoto, Takafumi; Kondo, Eri; Yamashita, Yui; Sakane, Yoriko; Kanai, Yugo; Ueda, Yohei; Yamauchi, Ichiro; Yamanaka, Shigeki; Nakao, Kazumasa; Kuwahara, Koichiro; Jindo, Toshimasa; Furuya, Mayumi; Mashimo, Tomoji; Inagaki, Nobuya; Serikawa, Tadao; Nakao, Kazuwa;


心不全バイオマーカーとしてのBNPの臨床的意義
診断と治療 = Diagnosis and treatment,105(12):1603-1607 2017(Dec.)
Author:桑原 宏一郎;
Keywords:脳性ナトリウム利尿ペプチド; ナトリウム利尿ペプチド; 心不全; バイオマーカー;


Prognostic Value of Ankle-Brachial Index in Patients Undergoing Percutaneous Coronary Intervention: In-Hospital and 1-Year Outcomes From the SHINANO Registry
ANGIOLOGY,68(10):884-892 2017(Nov.)
Author:Hashizume, Naoto; Miura, Takashi; Miyashita, Yusuke; Motoki, Hirohiko; Ebisawa, Soichiro; Izawa, Atsushi; Koyama, Jun; Ikeda, Uichi; Kuwahara, Koichiro; SHINANO Registry Investigators;


Cardiac hyaluronan may be associated with the persistence of atrial fibrillation
HEART AND VESSELS,32(9):1144-1150 2017(Sep.)
Author:Okada, Ayako; Kashima, Yuichiro; Tomita, Takeshi; Takeuchi, Takahiro; Oguchi, Yasutaka; Yoshie, Koji; Shoin, Wataru; Shoda, Morio; Nitta, Kenichi; Kuwahara, Koichiro; Imamura, Hiroshi;


Efficacy and Safety of an Orally Administered Selective Prostacyclin Receptor Agonist, Selexipag, in Japanese Patients With Pulmonary Arterial Hypertension
CIRCULATION JOURNAL,81(9):1360-1367 2017(Sep.)
Author:Tanabe, Nobuhiro; Ikeda, Satoshi; Tahara, Nobuhiro; Fukuda, Keiichi; Hatano, Masaru; Ito, Hiroshi; Nakayama, Tomotaka; Anzai, Toshihisa; Hashimoto, Akiyoshi; Inoue, Teruo; Kajinami, Kouji; Kihara, Yasuki; Kinoshita, Hideyuki; Kuwahara, Koichiro; Murohara, Toyoaki; Okazaki, Osamu; Sakai, Satoshi; Satoh, Toru; Takeda, Yutaka; Takeishi, Yasuchika; Taniguchi, Mitsugu; Watanabe, Hiroshi; Yamamoto, Takeshi; Yamauchi-Takihara, Keiko; Yoshioka, Koichiro; Sasayama, Shigetake;


Omecamtiv mecarbil
循環器内科 = Cardioangiology,82(2):169-172 2017(Aug.)
Author:木村 和広; 桑原 宏一郎;
Keywords:heart failure; myosin; inotropes;


B-Type Natriuretic Peptide in Heart Failure With Preserved Ejection Fraction
CIRCULATION JOURNAL,81(7):1006-+ 2017(Jul.)
Author:Harada, Eisaku; Mizuno, Yuji; Kugimiya, Fumihito; Shono, Makoto; Maeda, Hiroyuki; Yano, Naotsugu; Kuwahara, Koichiro; Yasue, Hirofumi;


Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model
JOURNAL OF VASCULAR SURGERY,65(6):1803-1812 2017(Jun.)
Author:Setozaki, Shuji; Minakata, Kenji; Masumoto, Hidetoshi; Hirao, Shingo; Yamazaki, Kazuhiro; Kuwahara, Koichiro; Ikeda, Tadashi; Sakata, Ryuzo;


Kyoto Congestive Heart Failure (KCHF) study: rationale and design
ESC Heart Failure,4(3):216-223 2017(Feb. 17)
Author:Yamamoto, Erika; Kato, Takao; Ozasa, Neiko; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Kitai, Takeshi; Morimoto, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Kawashima, Tsuneaki; Motohashi, Yasuyo; Kawato, Mitsunori; Toyofuku, Mamoru; Sato, Yukihito; Kuwahara, Koichiro; Shioi, Tetsuo; Kimura, Takeshi


MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts
JOURNAL OF THE AMERICAN HEART ASSOCIATION,6(2) 2017(Feb. 10)
Author:Nakagawa, Yasuaki; Nishikimi, Toshio; Kuwahara, Koichiro; Fujishima, Aoi; Oka, Shogo; Tsutamoto, Takayoshi; Kinoshita, Hideyuki; Nakao, Kazuhiro; Cho, Kosai; Inazumi, Hideaki; Okamoto, Hiroyuki; Nishida, Motohiro; Kato, Takao; Fukushima, Hiroyuki; Yamashita, Jun K.; Wijnen, Wino J.; Creemers, Esther E.; Kangawa, Kenji; Minamino, Naoto; Nakao, Kazuwa; Kimura, Takeshi


Endothelium-Derived C-Type Natriuretic Peptide Contributes to Blood Pressure Regulation by Maintaining Endothelial Integrity.
Hypertension,69(2):286-296 2017(Feb.)
Author:Nakao K, Kuwahara K, Nishikimi T, Nakagawa Y, Kinoshita H, Minami T, Kuwabara Y, Yamada C, Yamada Y, Tokudome T, Nagai-Okatani C, Minamino N, Nakao YM, Yasuno S, Ueshima K, Sone M, Kimura T, Kangawa K, Nakao K.


Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy.
J Am Soc Nephrol,28(1):278-289 2017(Jan.)
Author:Mori KP, Yokoi H, Kasahara M, Imamaki H, Ishii A, Kuwabara T, Koga K, Kato Y, Toda N, Ohno S, Kuwahara K, Endo T, Nakao K, Yanagita M, Mukoyama M, Mori K.


ナトリウム利尿ペプチドが変えた循環器診療
信州医学雑誌,65(5):247-248 2017
Author:桑原 宏一郎


心不全診療におけるナトリウム利尿ペプチドの臨床応用のインパクト
心臓,49(8):795-795 2017
Author:桑原 宏一郎


ナトリウム利尿ペプチドが変えた循環器診療
信州医学雑誌,65(5):247-248 2017
Author:桑原 宏一郎


心不全診療におけるナトリウム利尿ペプチドの臨床応用のインパクト
心臓,49(8):795-795 2017
Author:桑原 宏一郎


ナトリウム利尿ペプチドが変えた循環器診療
信州医学雑誌,65(5):247-248 2017
Author:桑原 宏一郎


心不全診療におけるナトリウム利尿ペプチドの臨床応用のインパクト
心臓,49(8):795-795 2017
Author:桑原 宏一郎


2-Year Natural History of Lower Limbs in Patients With End-stage Renal Disease on Hemodialysis Due to Diabetic Nephropathy; From PREDICT Study
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,70(18):B71-B71 2017
Author:Kato, Tamon; Miyashita, Yusuke; Miura, Takashi; Ebisawa, Souitirou; Saigusa, Tatsuya; Kuwahara, Koichiro;


ナトリウム利尿ペプチドが変えた循環器診療
信州医学雑誌,65(5):247-248 2017
Author:桑原 宏一郎;


Ankle-brachial Index for the Prognosis of Cardiovascular Disease in Patients with Mild Renal Insufficiency
INTERNAL MEDICINE,56(16):2103-2111 2017
Author:Nishimura, Hitoshi; Miura, Takashi; Minamisawa, Masatoshi; Ueki, Yasushi; Abe, Naoyuki; Hashizume, Naoto; Mochidome, Tomoaki; Harada, Mikiko; Shimizu, Kunihiko; Shoin, Wataru; Yoshie, Koji; Oguchi, Yasutaka; Ebisawa, Soichiro; Motoki, Hirohiko; Izawa, Atsushi; Koyama, Jun; Ikeda, Uichi; Kuwahara, Koichiro;


Impressive predictive value of ankle-brachial index for very long-term outcomes in patients with cardiovascular disease: IMPACT-ABI study
PLOS ONE,12(6) 2017
Author:Miura, Takashi; Minamisawa, Masatoshi; Ueki, Yasushi; Abe, Naoyuki; Nishimura, Hitoshi; Hashizume, Naoto; Mochidome, Tomoaki; Harada, Mikiko; Oguchi, Yasutaka; Yoshie, Koji; Shoin, Wataru; Saigusa, Tatsuya; Ebisawa, Soichiro; Motoki, Hirohiko; Koyama, Jun; Ikeda, Uichi; Kuwahara, Koichiro;


Diagnostic advantage of stress computed tomography myocardial perfusion over single-photon emission computed tomography for the assessment of myocardial ischemia
JOURNAL OF CARDIOLOGY,70(1-2):147-154 2017
Author:Ueki, Yasushi; Izawa, Atsushi; Kashiwagi, Daisuke; Nishiyama, Shigeki; Aso, Shinichi; Suzuki, Chihiro; Sakurai, Shumpei; Oguchi, Kazuhiro; Yazaki, Yoshikazu; Ikeda, Uichi; Kuwahara, Koichiro;


Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model
SCIENTIFIC REPORTS,7 2017
Author:Ogasawara, Tatsuki; Okano, Satomi; Ichimura, Hajime; Kadota, Shin; Tanaka, Yuki; Minami, Itsunari; Uesugi, Motonari; Wada, Yuko; Saito, Naoto; Okada, Kenji; Kuwahara, Koichiro; Shiba, Yuji;


TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.
Sci Rep,6:39383 2016(Dec.)
Author:Numaga-Tomita T, Kitajima N, Kuroda T, Nishimura A, Miyano K, Yasuda S, Kuwahara K, Sato Y, Ide T, Birnbaumer L, Sumimoto H, Mori Y, Nishida M.


Brain Natriuretic Peptide Counteracting the Renin-angiotensin-aldosterone System in Accelerated Malignant Hypertension.
Am J Med Sci,352(5):534-539 2016(Nov.)
Author:Nakagawa H, Mizuno Y, Harada E, Morikawa Y, Kuwahara K, Saito Y, Yasue H.


TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.
Sci Rep,6:37001 2016(Nov.)
Author:Kitajima N, Numaga-Tomita T, Watanabe M, Kuroda T, Nishimura A, Miyano K, Yasuda S, Kuwahara K, Sato Y, Ide T, Birnbaumer L, Sumimoto H, Mori Y, Nishida M.


【循環器疾患治療薬:薬の使い方、どこまで理解していますか?】 循環器薬を識る 利尿薬 バソプレシンV2受容体拮抗薬、hANP含む
Heart View,20(12):16-20 2016(Nov.)
Author:桑原宏一郎, 木村剛


僧帽弁逆流の成因解明にストレインエコーが有用であった心臓サルコイドーシスの一症例
日本サルコイドーシス/肉芽腫性疾患学会雑誌,36(1-2):79-83 2016(Oct.)
Author:米田智也, 木下秀之, 半田知宏, 長井苑子, 相澤卓範, 岡林真梨恵, 中島康弘, 中川靖章, 桑原宏一郎, 一山智, 木村剛


Brain-specific natriuretic peptide receptor-B deletion attenuates high-fat diet-induced visceral and hepatic lipid deposition in mice.
Peptides,81:38-50 2016(Jul.)
Author:Yamashita Y, Yamada-Goto N, Katsuura G, Ochi Y, Kanai Y, Miyazaki Y, Kuwahara K, Kanamoto N, Miura M, Yasoda A, Ohinata K, Inagaki N, Nakao K.


Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model.
J Vasc Surg,in press 2016(Jul.)
Author:Setozaki S, Minakata K, Masumoto H, Hirao S, Yamazaki K, Kuwahara K, Ikeda T, Sakata R.


Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure.
Sci Rep,6:27192 2016(Jun.)
Author:Ohno S, Yokoi H, Mori K, Kasahara M, Kuwahara K, Fujikura J, Naito M, Kuwabara T, Imamaki H, Ishii A, Saleem MA, Numata T, Mori Y, Nakao K, Yanagita M, Mukoyama M.


The renin-angiotensin system promotes arrhythmogenic substrates and lethal arrhythmias in mice with non-ischaemic cardiomyopathy.
Cardiovasc Res,109(1):162-73 2016(Jan.)
Author:Yamada C, Kuwahara K, Yamazaki M, Nakagawa Y, Nishikimi T, Kinoshita H, Kuwabara Y, Minami T, Yamada Y, Shibata J, Nakao K, Cho K, Arai Y, Honjo H, Kamiya K, Nakao K, Kimura T.


The renin-angiotensin system promotes arrhythmogenic substrates and lethal arrhythmias in mice with non-ischaemic cardiomyopathy
CARDIOVASCULAR RESEARCH,109(1):162-173 2016
Author:Yamada, Chinatsu; Kuwahara, Koichiro; Yamazaki, Masatoshi; Nakagawa, Yasuaki; Nishikimi, Toshio; Kinoshita, Hideyuki; Kuwabara, Yoshihiro; Minami, Takeya; Yamada, Yuko; Shibata, Junko; Nakao, Kazuhiro; Cho, Kosai; Arai, Yuji; Honjo, Haruo; Kamiya, Kaichiro; Nakao, Kazuwa; Kimura, Takeshi;


Secretion of ProBNP is Regulated by Mir30-GALNTs Axis Dependent O-linked Glycosylation in the Pathological Myocardium
CIRCULATION,134 2016
Author:Nakagawa, Yasuaki; Kuwahara, Koichiro; Nishikimi, Toshio; Kinoshita, Hideyuki; Inazumi, Hideki; Moriuchi, Kenji; Kato, Takao; Minamino, Naoto; Nacho, Kazuwa; Kimura, Takeshi;


【新しい循環器病のバイオマーカー-臨床的意義を理解する-】 循環器疾患における各種バイオマーカーの意義 BNP
Heart View,19(12):205-208 2015(Nov.)
Author:桑原宏一郎, 木村剛


PAHに伴う心肺病変について考えるシンポジウム 軽症PHを有する強皮症に対する病態評価と治療介入の是非 私はこのように対処している 自験例の紹介 京都大学での経験
Pulmonary Hypertension Update,1(Suppl.):155-160 2015(Oct.)
Author:木下秀之, 桑原宏一郎


Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites.
Am J Physiol Regul Integr Comp Physiol,309(6):R639-49 2015(Sep.)
Author:Nishikimi T, Nakagawa Y, Minamino N, Ikeda M, Tabei K, Fujishima A, Takayama K, Akimoto K, Yamada C, Nakao K, Minami T, Kuwabara Y, Kinoshita H, Tsutamoto T, Ishimitsu T, Kangawa K, Kuwahara K, Nakao K.


【心不全に対する多面的治療戦略-基礎から臨床へ-】 心不全におけるエピジェネティクス制御とその新規治療標的としての意義
循環器内科,78(2):145-148 2015(Aug.)
Author:桑原宏一郎, 木村剛


The organ-protective effect of N-type Ca(2+) channel blockade.
Pharmacol Ther,151:1-7 2015(Jul.)
Author:Kuwahara K, Kimura T.


【肥満と循環器病】 肥満と虚血性心疾患
循環器内科,77(6):519-522 2015(Jun.)
Author:桑原宏一郎, 木村剛


The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth.
Sci Rep,5:10554 2015(May)
Author:Nakao K, Osawa K, Yasoda A, Yamanaka S, Fujii T, Kondo E, Koyama N, Kanamoto N, Miura M, Kuwahara K, Akiyama H, Bessho K, Nakao K.


心血管疾患の病態と治療における最新知見 ナトリウム利尿ペプチドの心保護作用
循環plus,15(8):7-9 2015(May)
Author:桑原宏一郎, 木村剛, 中尾一和


Ectopic automaticity induced in ventricular myocytes by transgenic overexpression of HCN2.
J Mol Cell Cardiol,80:81-9 2015(Mar.)
Author:Oshita K, Itoh M, Hirashima S, Kuwabara Y, Ishihara K, Kuwahara K, Nakao K, Kimura T, Nakamura K, Ushijima K, Takano M.


Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model.
Sci Rep,5:7826 2015(Jan.)
Author:Tanaka M, Yamaguchi S, Yamazaki Y, Kinoshita H, Kuwahara K, Nakao K, Jay PY, Noda T, Nakamura T.


Differential Relationships Between Anemia and Outcome in Subgroups of Patients With Chronic Heart Failure.
Circ J,79(9):1893-4 2015
Author:Nakagawa Y, Yasuno S, Kuwahara K.


The Effects of Super-Flux (High Performance) Dialyzer on Plasma Glycosylated Pro-B-Type Natriuretic Peptide (proBNP) and Glycosylated N-Terminal proBNP in End-Stage Renal Disease Patients on Dialysis
PLOS ONE,9(3) 2014(Mar. 25)
Author:Nakagawa, Yasuaki; Nishikimi, Toshio; Kuwahara, Koichiro; Yasuno, Shinji; Kinoshita, Hideyuki; Kuwabara, Yoshihiro; Nakao, Kazuhiro; Minami, Takeya; Yamada, Chinatsu; Ueshima, Kenji; Ikeda, Yoshihiro; Okamoto, Hiroyuki; Horii, Kazukiyo; Nagata, Kiyoshi; Kangawa, Kenji; Minamino, Naoto; Nakao, Kazuwa


Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure
CARDIOVASCULAR RESEARCH,104(1):183-193 2014
Author:Yamada, Yuko; Kinoshita, Hideyuki; Kuwahara, Koichiro; Nakagawa, Yasuaki; Kuwabara, Yoshihiro; Minami, Takeya; Yamada, Chinatsu; Shibata, Junko; Nakao, Kazuhiro; Cho, Kosai; Arai, Yuji; Yasuno, Shinji; Nishikimi, Toshio; Ueshima, Kenji; Kamakura, Shiro; Nishida, Motohiro; Kiyonaka, Shigeki; Mori, Yasuo; Kimura, Takeshi; Kangawa, Kenji; Nakao, Kazuwa;


Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy
BRITISH JOURNAL OF PHARMACOLOGY,170(7):1384-1395 2013(Dec.)
Author:Yasuno, Shinji; Kuwahara, Koichiro; Kinoshita, Hideyuki; Yamada, Chinatsu; Nakagawa, Yasuaki; Usami, Satoru; Kuwabara, Yoshihiro; Ueshima, Kenji; Harada, Masaki; Nishikimi, Toshio; Nakao, Kazuwa;


Adrenomedullin in Cardiovascular Disease: A Useful Biomarker, its Pathological Roles and Therapeutic Application
CURRENT PROTEIN & PEPTIDE SCIENCE,14(4):256-267 2013(Jun.)
Author:Nishikimi, Toshio; Kuwahara, Koichiro; Nakagawa, Yasuaki; Kangawa, Kenji; Nakao, Kazuwa;


Increased Expression of HCN Channels in the Ventricular Myocardium Contributes to Enhanced Arrhythmicity in Mouse Failing Hearts
JOURNAL OF THE AMERICAN HEART ASSOCIATION,2(3) 2013(Jun.)
Author:Kuwabara, Yoshihiro; Kuwahara, Koichiro; Takano, Makoto; Kinoshita, Hideyuki; Arai, Yuji; Yasuno, Shinji; Nakagawa, Yasuaki; Igata, Sachiyo; Usami, Satoru; Minami, Takeya; Yamada, Yuko; Nakao, Kazuhiro; Yamada, Chinatsu; Shibata, Junko; Nishikimi, Toshio; Ueshima, Kenji; Nakao, Kazuwa;


Complexity of molecular forms of B-type natriuretic peptide in heart failure
HEART,99(10):677-679 2013(May)
Author:Nishikimi, Toshio; Kuwahara, Koichiro; Nakagawa, Yasuaki; Kangawa, Kenji; Minamino, Naoto; Nakao, Kazuwa;


Direct Immunochemiluminescent Assay for proBNP and Total BNP in Human Plasma proBNP and Total BNP Levels in Normal and Heart Failure
PLOS ONE,8(1) 2013
Author:Nishikimi, Toshio; Okamoto, Hiroyuki; Nakamura, Masahiro; Ogawa, Naoko; Horii, Kazukiyo; Nagata, Kiyoshi; Nakagawa, Yasuaki; Kinoshita, Hideyuki; Yamada, Chinatsu; Nakao, Kazuhiro; Minami, Takeya; Kuwabara, Yoshihiro; Kuwahara, Koichiro; Masuda, Izuru; Kangawa, Kenji; Minamino, Naoto; Nakao, Kazuwa;


Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,434(2):210-216 2013
Author:Nishida, Motohiro; Ishikawa, Tatsuya; Saiki, Shota; Sunggip, Caroline; Aritomi, Shizuka; Harada, Eri; Kuwahara, Koichiro; Hirano, Katsuya; Mori, Yasuo; Kim-Mitsuyama, Shokei;


Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice
EMBO JOURNAL,31(23):4428-4440 2012
Author:Minami, Takeya; Kuwahara, Koichiro; Nakagawa, Yasuaki; Takaoka, Minoru; Kinoshita, Hideyuki; Nakao, Kazuhiro; Kuwabara, Yoshihiro; Yamada, Yuko; Yamada, Chinatsu; Shibata, Junko; Usami, Satoru; Yasuno, Shinji; Nishikimi, Toshio; Ueshima, Kenji; Sata, Masataka; Nakano, Hiroyasu; Seno, Takahiro; Kawahito, Yutaka; Sobue, Kenji; Kimura, Akinori; Nagai, Ryozo; Nakao, Kazuwa;


Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,50(6):972-981 2011(Jun.)
Author:Hata, Leo; Murakami, Masao; Kuwahara, Koichiro; Nakagawa, Yasuaki; Kinoshita, Hideyuki; Usami, Satoru; Yasuno, Shinji; Fujiwara, Masataka; Kuwabara, Yoshihiro; Minami, Takeya; Yamada, Yuko; Yamada, Chinatsu; Nakao, Kazuhiro; Ueshima, Kenji; Nishikimi, Toshio; Nakao, Kazuwa;


Induction and Enhancement of Cardiac Cell Differentiation from Mouse and Human Induced Pluripotent Stem Cells with Cyclosporin-A
PLOS ONE,6(2) 2011
Author:Fujiwara, Masataka; Yan, Peishi; Otsuji, Tomomi G.; Narazaki, Genta; Uosaki, Hideki; Fukushima, Hiroyuki; Kuwahara, Koichiro; Harada, Masaki; Matsuda, Hiroyuki; Matsuoka, Satoshi; Okita, Keisuke; Takahashi, Kazutoshi; Nakagawa, Masato; Ikeda, Tadashi; Sakata, Ryuzo; Mummery, Christine L.; Nakatsuji, Norio; Yamanaka, Shinya; Nakao, Kazuwa; Yamashita, Jun K.;


Pathophysiological Remodeling of Mouse Cardiac Myocytes Expressing Dominant Negative Mutant of Neuron Restrictive Silencing Factor
CIRCULATION JOURNAL,74(12):2712-2719 2010(Dec.)
Author:Takano, Makoto; Kinoshita, Hideyuki; Shioya, Takao; Itoh, Masayuki; Nakao, Kazuwa; Kuwahara, Koichiro;


Myocardin-Related Transcription Factor A Is a Common Mediator of Mechanical Stress- and Neurohumoral Stimulation-Induced Cardiac Hypertrophic Signaling Leading to Activation of Brain Natriuretic Peptide Gene Expression
MOLECULAR AND CELLULAR BIOLOGY,30(17):4134-4148 2010(Sep.)
Author:Kuwahara, Koichiro; Kinoshita, Hideyuki; Kuwabara, Yoshihiro; Nakagawa, Yasuaki; Usami, Satoru; Minami, Takeya; Yamada, Yuko; Fujiwara, Masataka; Nakao, Kazuwa;


Podocyte-specific expression of tamoxifen-inducible Cre recombinase in mice
NEPHROLOGY DIALYSIS TRANSPLANTATION,25(7):2120-2124 2010(Jul.)
Author:Yokoi, Hideki; Kasahara, Masato; Mukoyama, Masashi; Mori, Kiyoshi; Kuwahara, Koichiro; Fujikura, Junji; Arai, Yuji; Saito, Yoko; Ogawa, Yoshihisa; Kuwabara, Takashige; Sugawara, Akira; Nakao, Kazuwa;


Regulation and significance of atrial and brain natriuretic peptides as cardiac hormones
ENDOCRINE JOURNAL,57(7):555-565 2010(Jul.)
Author:Kuwahara, Koichiro; Nakao, Kazuwa;


Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart
CIRCULATION RESEARCH,106(12):1849-U153 2010
Author:Kinoshita, Hideyuki; Kuwahara, Koichiro; Nishida, Motohiro; Jian, Zhong; Rong, Xianglu; Kiyonaka, Shigeki; Kuwabara, Yoshihiro; Kurose, Hitoshi; Inoue, Ryuji; Mori, Yasuo; Li, Yuhao; Nakagawa, Yasuaki; Usami, Satoru; Fujiwara, Masataka; Yamada, Yuko; Minami, Takeya; Ueshima, Kenji; Nakao, Kazuwa;


Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction
CIRCULATION RESEARCH,107(2):294-U263 2010
Author:Small, Eric M.; Thatcher, Jeffrey E.; Sutherland, Lillian B.; Kinoshita, Hideyuki; Gerard, Robert D.; Richardson, James A.; DiMaio, J. Michael; Sadek, Hesham; Kuwahara, Koichiro; Olson, Eric N.;


Guanylyl Cyclase-A Inhibits Angiotensin II Type 2 Receptor-Mediated Pro-Hypertrophic Signaling in the Heart
ENDOCRINOLOGY,150(8):3759-3765 2009(Aug.)
Author:Li, Yuhao; Saito, Yoshihiko; Kuwahara, Koichiro; Rong, Xianglu; Kishimoto, Ichiro; Harada, Masaki; Adachi, Yuichiro; Nakanishi, Michio; Kinoshita, Hideyuki; Horiuchi, Masatsugu; Murray, Michael; Nakao, Kazuwa;


The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2
CARDIOVASCULAR RESEARCH,83(4):682-687 2009
Author:Kuratomi, Shinobu; Ohmori, Yoko; Ito, Masayuki; Shimazaki, Kuniko; Muramatsu, Shin-ichi; Mizukami, Hiroaki; Uosaki, Hideki; Yamashita, Jun K.; Arai, Yuji; Kuwahara, Koichiro; Takano, Makoto;


T-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice With Heart Failure
CIRCULATION,120(9):743-U66 2009
Author:Kinoshita, Hideyuki; Kuwahara, Koichiro; Takano, Makoto; Arai, Yuji; Kuwabara, Yoshihiro; Yasuno, Shinji; Nakagawa, Yasuaki; Nakanishi, Michio; Harada, Masaki; Fujiwara, Masataka; Murakami, Masao; Ueshima, Kenji; Nakao, Kazuwa;


p300 Plays a Critical Role in Maintaining Cardiac Mitochondrial Function and Cell Survival in Postnatal Hearts
CIRCULATION RESEARCH,105(8):746-U57 2009
Author:Nakagawa, Yasuaki; Kuwahara, Koichiro; Takemura, Genzo; Akao, Masaharu; Kato, Masashi; Arai, Yuji; Takano, Makoto; Harada, Masaki; Murakami, Masao; Nakanishi, Michio; Usami, Satoru; Yasuno, Shinji; Kinoshita, Hideyuki; Fujiwara, Masataka; Ueshima, Kenji; Nakao, Kazuwa;


Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation
CIRCULATION JOURNAL,71(8):1310-1316 2007(Aug.)
Author:Nakanishi, Michio; Harada, Masaki; Kishimoto, Ichiro; Kuwahara, Koichiro; Kawakami, Rika; Nakagawa, Yasuaki; Yasuno, Shinji; Usami, Satoru; Kinoshita, Hideyuki; Adachi, Yuichiro; Fukamizu, Akiyoshi; Saito, Yoshihiko; Nakao, Kazuwa;


Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity
JOURNAL OF CLINICAL INVESTIGATION,117(5):1324-1334 2007(May)
Author:Kuwahara, Koichiro; Pipes, Gordon C. Teg; McAnally, John; Richardson, James A.; Hill, Joseph A.; Bassel-Duby, Rhonda; Olson, Eric N.;


Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin
JOURNAL OF BIOLOGICAL CHEMISTRY,282(11):8393-8403 2007
Author:Barrientos, Tomasa; Frank, Derk; Kuwahara, Koichiro; Bezprozvannaya, Svetlana; Pipes, G. C. Teg; Bassel-Duby, Rhonda; Richardson, James A.; Katus, Hugo A.; Olson, Eric N.; Frey, Norbert;


Mitochondrial cardiomyopathy evaluated with cardiac magnetic resonance
CIRCULATION,116(2):E25-E26 2007
Author:Nakanishi, Michio; Harada, Masaki; Tadamura, Eiji; Kotani, Hirokazu; Kawakami, Rika; Kuwahara, Koichiro; Nakagawa, Yasuaki; Usami, Satoru; Kinoshita, Hideyuki; Fujiwara, Masataka; Hosoda, Kiminori; Ueshima, Kenji; Nakao, Kazuwa;


TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
JOURNAL OF CLINICAL INVESTIGATION,116(12):3114-3126 2006(Dec.)
Author:Kuwahara, Koichiro; Wang, Yanggan; McAnally, John; Richardson, James A.; Bassel-Duby, Rhonda; Hill, Joseph A.; Olson, Eric N.;


Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,41(6):1010-1022 2006(Dec.)
Author:Nakagawa, Yasuaki; Kuwahara, Koichiro; Harada, Masaki; Takahashi, Nobuki; Yasuno, Shinji; Adachi, Yuichiro; Kawakami, Rika; Nakanishi, Michio; Tanimoto, Keiji; Usami, Satoru; Kinoshita, Hideyuki; Saito, Yoshihiko; Nakao, Kazuwa;


講演・口頭発表等
デュアルインピーダンス法による計測された内臓脂肪面積と自宅血圧の日間変動指標との関連の検討
日本高血圧学会臨床高血圧フォーラムプログラム・抄録集 5 165 2016(May)
Presenter:桑原純子, 桑原宏一郎, 堀井和子, 桑原佳宏, 保野慎治, 保野明子, 藤永有理子, 中川靖章, 木下秀之, 山田千夏, 横井秀基, 曽根正勝, 上嶋健治, 中尾一和, 木村剛


当院におけるILD-PHに対する肺血管拡張療法の効果の検討
呼吸と循環 64 5 S42 2016(May)
Presenter:藤田啓誠, 木下秀之, 半田知宏, 谷澤公伸, 室繁郎, 佐藤晋, 山田千夏, 中川靖章, 静田聡, 桑原宏一郎, 木村剛


膠原病関連肺高血圧症とCT所見
呼吸と循環 64 5 S46-S47 2016(May)
Presenter:柳澤洋, 木下秀之, 吉藤元, 半田知宏, 藤井隆夫, 牧山武, 中川靖章, 静田聡, 桑原宏一郎, 三森経世, 木村剛


重症肺高血圧症を合併した肺線維症と考えられた1症例
呼吸と循環 64 5 S52-S53 2016(May)
Presenter:柳澤洋, 木下秀之, 佐藤雅昭, 桜井孝規, 半田知宏, 今井逸雄, 中川靖章, 静田聡, 桑原宏一郎, 伊達洋至, 木村剛


低酸素血症を伴う重症特発性肺動脈性肺高血圧症患者の臨床経過
呼吸と循環 64 5 S54 2016(May)
Presenter:相澤卓範, 木下秀之, 中西直彦, 桜井孝規, 今井逸雄, 中川靖章, 静田聡, 桑原宏一郎, 青山晃博, 伊達洋至, 木村剛


重症PAHにおける肺移植術後急性期の右室および左室機能の検討
呼吸と循環 64 5 S57 2016(May)
Presenter:米田智也, 木下秀之, 中島康弘, 本山秀樹, 土屋恭子, 青山晃博, 陳豊史, 桑原宏一郎, 木村剛, 伊達洋至, 一山智


糖尿病性腎症におけるN型Ca2+チャネル阻害の腎保護効果
日本内分泌学会雑誌 92 1 212 2016(Apr.)
Presenter:大野祥子, 横井秀基, 笠原正登, 森潔, 桑原宏一郎, 藤倉純二, 内藤雅喜, 桑原孝成, 菅原照, 柳田素子, 中尾一和, 向山政志


O型糖転移酵素GALNTのBNPプロセシング調節への関与
日本内分泌学会雑誌 92 1 256 2016(Apr.)
Presenter:中川靖章, 錦見俊雄, 桑原宏一郎, 木下秀之, 山田千夏, 稲住英明, 南野直人, 中尾一和, 木村剛


miR30-GALNT経路によるO型糖鎖修飾を介したBNPプロセシング調節が病的心筋からのproBNP分泌亢進に寄与する
日本臨床分子医学会学術総会プログラム・抄録集 53 75 2016(Apr.)
Presenter:中川靖章, 錦見俊雄, 桑原宏一郎, 保野慎治, 木下秀之, 桑原佳宏, 山田千夏, 稲住英明, 上嶋健治, 南野直人, 中尾一和, 木村剛


O型糖鎖修飾を介したヒトBNPプロセシング調節に関与する糖転移酵素についての検討
日本内分泌学会雑誌 91 2 643 2015(Sep.)
Presenter:中川靖章, 錦見俊雄, 桑原宏一郎, 木下秀之, 山田千夏, 南野直人, 中尾一和, 木村剛


心不全患者におけるproBNPの分泌と代謝についての検討
日本内分泌学会雑誌 91 2 644 2015(Sep.)
Presenter:中川靖章, 錦見俊雄, 桑原宏一郎, 木下秀之, 山田千夏, 南野直人, 中尾一和, 木村剛


肺動脈性肺高血圧症における肺移植術後早期の左室機能の検討
呼吸と循環 63 8 S44 2015(Aug.)
Presenter:米田智也, 木下秀之, 土井孝浩, 山田徹, 佐藤雅昭, 青山晃博, 陳豊史, 桑原宏一郎, 伊達洋至, 木村剛


肺血管拡張薬中止理由の検討と病棟専従薬剤師の役割の考察
呼吸と循環 63 8 S55-S56 2015(Aug.)
Presenter:吉田優子, 木下秀之, 吉田詩織, 木下美津子, 中川靖章, 牧山武, 静田聡, 桑原宏一郎, 木村剛, 松原和夫


肺高血圧症合併肺ランゲルハンス細胞組織球症に対する治療経過
呼吸と循環 63 8 S57 2015(Aug.)
Presenter:柳澤洋, 木下秀之, 山田徹, 半田知宏, 中川靖章, 牧山武, 静田聡, 桑原宏一郎, 伊達洋至, 木村剛


糖尿病性腎症におけるN型Ca2+チャネル阻害の腎保護効果
日本腎臓学会誌 57 3 569 2015(Apr.)
Presenter:大野祥子, 横井秀基, 笠原正登, 森潔, 桑原宏一郎, 藤倉純二, 内藤雅喜, 桑原孝成, 今牧博貴, 石井輝, 古賀健一, 塩田文彦, 沼田朋大, 菅原照, 森泰生, 中尾一和, 柳田素子, 向山政志


心不全に伴う不整脈源性基質形成におけるレニン・アンジオテンシン系の意義
先進医薬研究振興財団研究成果報告集 2014 166-167 2015(Mar.)
Presenter:桑原宏一郎


シルニジピンによる糖尿病性腎症の進行抑制機序の検討
日本内科学会雑誌 104 Suppl. 264 2015(Feb.)
Presenter:大野祥子, 横井秀基, 笠原正登, 森潔, 桑原宏一郎, 塩田文彦, 菅原照, 中尾一和, 柳田素子, 向山政志


心不全研究のカッティング・エッジ 心不全に伴う不整脈突然死発症にかかわる分子メカニズム
血管 38 1 26 2015(Jan.)
Presenter:桑原宏一郎, 中尾一和, 木村剛