論文 NanoSPECT imaging reveals the uptake of 123I-labeled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36. Cardiovasc Res,119:1008-1020 2023 Author:Hosomi, K., Kawashima, H., Nakano, A., Kakino, A., Okamatsu-Ogura, Y., Yamashita, Y., Sasaoka, M., Masuda, D., Yamashita, S., Chen, C.H., Yuzuriha, S., Hosoda, H., Iida, H. and Sawamura, T.
LOX-1 deficiency increases ruptured abdominal aortic aneurysm via thinning of adventitial collagen. Hypertens Res,46:63-74 2023 Author:Takahashi, K., Aono, J., Nakao, Y., Hamaguchi, M., Suehiro, C., Kurata, M., Sakaue, T., Kakino, A., Sawamura, T., Inoue, K., Ikeda, S., Suzuki, J. and Yamaguchi, O.
Serum modified high-density lipoprotein and risk of atherosclerotic cardiovascular disease in a Japanese community-based nested case-control study. Eur J Prev Cardiol,29:e193-e195 2022 Author:Sata, M., Kakino, A. (co-first author), Hirata, A., Iida, M., Usami, Y., Harada, S., Fujita, Y., Kohsaka, S., Izawa, Y., Sawano, M., Oki, K., Sugiyama, D., Takahashi, S., Takebayashi, T., Sawamura, T. and Okamura, T.
The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor iScience,24:102076 2021 Author:Takahashi, T., Huang, Y., Yamamoto, K., Hamano, G., Kakino, A., Kang, F., Imaizumi, Y., Takeshita, H., Nozato, Y., Nozato, S., Yokoyama, S., Nagasawa, M., Kawai, T., Takeda, T., Fujimoto, T., Hongyo, K., Nakagami, F., Akasaka, H., Takami, Y., Takeya, Y., Sugimoto, K., Gaisano, H.Y., Sawamura, T. and Rakugi, H.
RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane. Sci Rep,11:5759 2021 Author:Yokoyama, S., Kawai, T., Yamamoto, K., Yibin, H., Yamamoto, H., Kakino, A., Takeshita, H., Nozato, Y., Fujimoto, T., Hongyo, K., Takahashi, T., Nakagami, F., Akasaka, H., Takami, Y., Takeya, Y., Sugimoto, K., Sawamura, T. and Rakugi, H.
Quantitative and qualitative lipid improvement with chronic hepatitis C virus eradication using with direct-acting antivirals. Hepatol Res,51:758-766 2021 Author:Joshita, S., Yamashita, Y., Okamoto, T., Usami, Y., Sugiura, A., Yamazaki, T., Kakino, A., Ota, M., Sawamura, T. and Umemura, T.
Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model. Sci Rep,11:15675 2021 Author:Ohno, M., Kakino, A., Sekiya, T., Nomura, N., Shingai, M., Sawamura, T. and Kida, H.
Abnormal blood coagulation and kidney damage in aged hamsters infected with severe acute respiratory syndrome coronavirus 2. Viruses,13:2137 2021 Author:Ohno, M., Sasaki, M., Orba, Y., Sekiya, T., Masum, M.A., Ichii, O., Sawamura, T., Kakino, A., Suzuki, Y., Kida, H., Sawa, H. and Shingai, M.
Detection of a high ratio of soluble to membrane-bound LOX-1 in aspirated coronary thrombi from patients with ST-segment-elevation myocardial infarction. J Am Heart Assoc,9:e014008 2020 Author:Lee, A.S., Wang, Y.C., Chang, S.S., Lo, P.H., Chang, C.M., Lu, J., Burns, A.R., Chen, C.H., Kakino, A., Sawamura, T. and Chang, K.C.
LDL uptake-dependent phosphatidylethanolamine translocation to the cell surface promotes fusion of osteoclast-like cells. J Cell Sci,133:jcs243840 2020 Author:Kitano, V.J.F., Ohyama, Y., Hayashida, C., Ito, J., Okayasu, M., Sato, T., Ogasawara, T., Tsujita, M., Kakino, A., Shimada, J., Sawamura, T. and Hakeda, Y.
LOX-1 deletion has protective effects on stroke in the genetic background of stroke-prone spontaneously hypertensive rat. Stroke,51:1835-1843 2020 Author:Liang, Y.Q., Kakino, A. (co-first author), Matsuzaka, Y., Mashimo, T., Isono, M., Akamatsu, T., Shimizu-Furusawa, H., Tajima, M., Kaneko, T., Li, L., Takeuchi, F., Sawamura, T. and Kato, N.
The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men. Atherosclerosis,313:20-25 2020 Author:Hirata, A., Kakino, A., Okamura, T., Usami, Y., Fujita, Y., Kadota, A., Fujiyoshi, A., Hisamatsu, T., Kondo, K., Segawa, H., Sawamura, T., Miura, K. and Ueshima, H.
A novel cell-free, non-fluorescent method to measure LOX-1-binding activity corresponding to the functional activity of HDL. J Atheroscler Thromb,26:947-958 2019 Author:Kakino, A., Usami, Y., Horiuchi, S., Fujita, Y., Kotani, K., Chen, C.H., Okamura, T. and Sawamura, T.
123I-labeled oxLDL is widely distributed throughout the whole body in mice. Nucl Med Mol Imaging,52:144-153 2018 Author:Nakano, A., Kawashima, H., Miyake, Y., Zeniya, T., Yamamoto, A., Koshino, K., Temma, T., Fukuda, T., Fujita, Y., Kakino, A., Kanaya, S., Sawamura, T. and Iida, H.
Deletion of LOX-1 protects against heart failure induced by doxorubicin. PLoS One,11:e0154994 2016 Author:Yokoyama, C., Aoyama, T., Ido, T., Kakino, A., Shiraki, T., Tanaka, T., Nishigaki, K., Hasegawa, A., Fujita, Y., Sawamura, T. and Minatoguchi, S.
High levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 in acute stroke: An age- and sex-matched cross-sectional study. J Atheroscler Thromb,23:1222-1226 2016 Author:Yokota, C., Sawamura, T., Watanabe, M., Kokubo, Y., Fujita, Y., Kakino, A., Nakai, M., Toyoda, K., Miyamoto, Y. and Minematsu, K.
Developmental endothelial locus-1 (Del-1) inhibits oxidized low-density lipoprotein activity by direct binding, and its overexpression attenuates atherogenesis in mice. Circ J,80:2541-2549 2016 Author:Kakino, A., Fujita, Y., Nakano, A., Horiuchi, S. and Sawamura, T.
Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state. Bone,75:170-182 2015 Author:Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura, T. and Hakeda, Y.
Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor. FASEB J,29:3342-3356 2015 Author:Yamamoto, K., Kakino, A. (co-first author), Takeshita, H., Hayashi, N., Li, L., Nakano, A., Hanasaki-Yamamoto, H., Fujita, Y., Imaizumi, Y., Toyama-Yokoyama, S., Nakama, C., Kawai, T., Takeda, M., Hongyo, K., Oguro, R., Maekawa, Y., Itoh, N., Takami, Y., Onishi, M., Takeya, Y., Sugimoto, K., Kamide, K., Nakagami, H., Ohishi, M., Kurtz, T.W., Sawamura, T. and Rakugi, H.
LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men. Atherosclerosis,229:240-245 2013 Author:Okamura, T., Sekikawa, A., Sawamura, T., Kadowaki, T., Barinas-Mitchell, E., Mackey, R.H., Kadota, A., Evans, R.W., Edmundowicz, D., Higashiyama, A., Nakamura, Y., Abbott, R.D., Miura, K., Fujiyoshi, A., Fujita, Y., Murakami, Y., Miyamatsu, N., Kakino, A., Maegawa, H., Murata, K., Horie, M., Mitsunami, K., Kashiwagi, A., Kuller, L.H., Ueshima, H. and Group, E.J.S.
Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis. Arthritis Rheum,64:1024-1034 2012 Author:Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.
Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox. Proc Jpn Acad Ser B Phys Biol Sci,87:104-113 2011 Author:Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R. and Sawamura, T.
An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) - utilization of anti-LOX-1 single- chain antibody fused to apoB fragment. J Atheroscler Thromb,18:818-828 2011 Author:Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R. and Sawamura, T.
Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation. Clin Chem,57:1398-1405 2011 Author:Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R. and Sawamura, T.
C-reactive protein uptake by macrophage cell line via class-A scavenger receptor. Clin Chem,56:478-481 2010 Author:Fujita, Y., Kakino, A., Harada-Shiba, M., Sato, Y., Otsui, K., Yoshimoto, R. and Sawamura, T.
LOX index, a novel predictive biochemical marker for coronary heart disease and stroke. Clin Chem,56:550-558 2010 Author:Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R. and Sawamura, T.
LOX-1 mediates vascular lipid retention under hypertensive state. J Hypertens,28:1273-1280 2010 Author:Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H. and Sawamura, T.
Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans. Lipids,45:329-335 2010 Author:Matsumoto, T., Fujita, M., Sawamura, T., Kakino, A., Sato, Y., Fujita, Y., Matsuda, H., Nakanishi, M., Uchida, K., Nakae, I., Kanda, H., Yoshida, A., Miwa, K., Hayashi, H., Mitsunami, K. and Horie, M.
Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects. Clin Chem,55:285-294 2009 Author:Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini, L., Delneste, Y., Matsuda, H. and Sawamura, T.
LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells. Cardiovasc Res,84:127-136 2009 Author:Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita, H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., Takuwa, Y., Kakino, A., Fujita, Y., Tanaka, T., Teramoto, T., Maruyama, Y. and Takeishi, Y.
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol Cell Biol,27:7028-7040 2007 Author:Ikura, T., Tashiro, S., Kakino, A., Shima, H., Jacob, N., Amunugama, R., Yoder, K., Izumi, S., Kuraoka, I., Tanaka, K., Kimura, H., Ikura, M., Nishikubo, S., Ito, T., Muto, A., Miyagawa, K., Takeda, S., Fishel, R., Igarashi, K. and Kamiya, K.
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