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中山 淳  ナカヤマ ジュン

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 分子病理学教室FAX番号
職名副学長 教授メールアドレスjnaka@shinshu-u.ac.jp
住所ホームページURLhttp://www.shinshu-u.ac.jp/faculty/medicine/chair/i-2byori/index.html

更新日:2022/12/14

プロフィール

研究分野
病理学
糖鎖生物学
組織細胞化学
臨床検査医学
現在の研究課題
胃腺粘液糖鎖による胃癌発生の制御機構
キーワード:糖鎖遺伝子 ノックアウトマウス , 2000-
腫瘍における糖鎖並びに糖鎖関連分子の発現解析とその臨床病理学的意義の解明
キーワード:糖鎖 腫瘍の悪性度 , 1995-
病理学における組織細胞化学の応用
キーワード:組織細胞化学 診断病理学 , 1995-
所属学会
所属学会
日本病理学会
日本癌学会
日本臨床細胞学会
日本組織細胞化学会
日本分子腫瘍マーカー研究会
日本消化器癌発生学会
日本臨床検査医学会
日本神経学会
日本生化学会
日本糖質学会
日本内科学会
日本神経病理学会
日本小児病理研究会
日本がん転移学会
American Association for Cancer Research
The American Society for Cell Biology
The Histochemical Society

所属学会役職担当
日本病理学会 , 学術評議員
日本臨床細胞学会 , 評議員
日本糖質学会 , 評議員
日本癌学会 , 評議員
日本組織細胞化学会 , 常任理事、評議員
日本消化器癌発生学会 , 代議員
日本神経病理学会 , 代議員
日本生化学会 , 評議員
日本がん転移学会 , 評議員
日本分子腫瘍マーカー研究会 , 世話人
日本糖鎖科学コンソーシアム , 幹事
学歴
出身大学院
1987 , 信州大学 , 医学研究科

出身学校・専攻等(大学院を除く)
1983 , 信州大学 , 医学部

取得学位
医学博士 , 信州大学

免許・資格等
日本専門医機構認定病理専門医
日本専門医機構認定臨床検査専門医
日本臨床細胞学会認定細胞診専門医
日本病理学会認定病理専門医研修指導医
日本臨床検査医学会臨床検査管理医
日本神経学会認定神経内科専門医
受賞学術賞
2016 , 科研費審査員表彰
2013 , 日本病理学会 日本病理学賞
2013 , 日本組織細胞化学会 学会賞 (高松賞)
1999 , 日本臨床検査医学会 Bergmeyer-Kawai賞
1997 , 松医会賞
1997 , 日本病理学会 学術研究賞
研究職歴等
研究職歴
2020- , 信州大学 卓越教授
2002- , 信州大学医学部 教授
2000-2002 , 信州大学大学院(医学研究科) 助教授
1992-2000 , 信州大学医学部附属病院 講師
1989-1992 , 信州大学医学部附属病院 助手
1987-1989 , 信州大学医学部附属病院 医員(中央検査部)

研究職歴以外の職歴
2021- , 信州大学 副学長
2019- , 信州大学 医学部長
2017- , 日本学術会議連携会員
2016-2019 , 信州大学 附属図書館 医学部図書館長
2016-2019 , 信州大学 医学部長補佐
2011-2016 , 信州大学 副医学部長

留学歴
1993-1995 , ラホヤ癌研究所

研究活動業績

研究業績(著書・
発表論文等)
書籍等出版物
Gastric cancer, Glycoscience: Basic Science to Applications – Insights from the Japan Consortium for Glycobiology and Glycotechnology, 303-304
Springer-Nature Singapore 2019
Author:Nakayama J


Function of unique O-glycan structures in protecting gastric mucosa against Helicobacter pylori infection and gastric cancer development, Glycosignals in Cancer: Mechanisms of Malignant Phenotypes , 111-124
Springer Japan 2016
Author:Nakayama J


Helicobacter pylori, Glycoscience: Biology and Medicine , 723-729
Springer Japan 2014
Author:Kawakubo M, Ito Y, Fukuda M, Nakayama J


Alpha-1,4-N-acetylglucosaminyltransferase (A4GNT), Handbook of Glycosyltransferases and Related Genes, 2nd ed. , 379-391
Springer Japan 2014
Author:Nakayama J


ST8Sia-IV (PST-1), Taniguchi N, Honke K, Fukuda M eds: Handbook of Glycosyltransferases and Related Genes , 340-346
2002
Author:Nakayama J, Angata K, Suzuki M, Fukuda M


論文
胃腺粘液型糖鎖による生体防御と上皮性腫瘍の悪性化制御機構
信州医学雑誌,70(5):257-269 2022(Oct.)
Author:藤井 千文, 中山 淳


MUC6 expression is a preferable prognostic marker for invasive mucinous adenocarcinoma of the lung.
Histochem Cell Biol,157:671-684 2022
Author:Yamanoi K, Fujii C, Yuzuriha H, Kumazawa M, Shimoda M, Emoto K, Asamura H, Nakayama J


Mucin distribution in bronchiolar adenoma/ciliated muconodular papillary tumor reveals organoid differentiation simulating the normal lung.
Pathol Int ,72:300-306 2022
Author:Matoba H, Ikeyama M, Kobayashi N, Takemura H, Hanaoka T, Sato Y, Nakayama J


Acidic activated charcoal prevents obesity and insulin resistance in high-fat diet-fed mice.
Front Nutr,9:852767 2022
Author:Zhang X, Diao P, Yokoyama H, Inoue Y, Tanabe K, Hayashi C, Yokoyama T, Zhang Z, Hu X, Nakajima T, Kimura T, Nakayama J, Nakamuta M, Tanaka N


Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy.
Cancer Sci,113:576-586 2022
Author:Yuki A, Fujii C, Yamanoi K, Matoba H, Harumiya S, Kawakubo M, Nakayama J


Decreased gastric gland mucin-specific O-glycans are involved in the progression of ovarian primary mucinous tumours.
Acta Histochem Cytochem,54:115-122 2021
Author:Ohya A, Matoba H, Fujinaga Y, Nakayama J


Effects of orally administered Euglena gracilis and its reserve polysaccharide, paramylon, on gastric dysplasia in A4gnt knockout mice.
Sci Rep,11:13640 2021
Author:Iida M, Desamero MJ, Yasuda K, Nakashima A, Suzuki K, Chambers JK, Uchida K, Ogawa R, Hachimura S, Nakayama J, Kyuwa S, Miura K, Kakuta S, Hirayama K


Cholestenone functions as an antibiotic against Helicobacter pylori by inhibiting biosynthesis of the cell wall component CGL.
Proc Natl Acad Sci USA,118:e2016469118 2021
Author:Kobayashi J, Kawakubo M, Fujii C, Arisaka N, Miyashita M, Sato Y, Komura H, Matoba H, Nakayama J


Systematic investigation of the skin in Chst14-/- mice: a model for skin fragility in musculocontractural Ehlers-Danlos syndrome caused by CHST14 variants (mcEDS-CHST14).
Glycobiology ,31:137-150 2021
Author:Hirose T, Mizumoto S, Hashimoto A, Takahashi Y, Yoshizawa T, Nitahara-Kasahara Y, Takahashi N, Nakayama J, Takehana K, Okada T, Nomura Y, Yamada S, Kosho T, Watanabe T


Decreased alpha-1,4-linked N-acetylglucosamine glycosylation in biliary tract cancer progression from biliary intraepithelial neoplasia to invasive adenocarcinoma.
Cancer Sci,111:4629-4635 2020
Author:Okumura M, Yamanoi K, Uehara T, Nakayama J


Overcoming the blood-brain-barrier by Annexin A1-binding peptide to target brain tumors.
Brit J Cancer,123:1633-1643 2020
Author:Nonaka M, Suzuki-Anekoji M, Nakayama J, Mabashi-Asazuma H, Jarvis DL, Yeh J, Yamasaki K, Akama TO, Huang C, Campos AR, Nagaoka M, Sasai T, Kimura-Takagi I, Suwa Y, Yaegashi T, Shibata TK, Sugihara K, Nishizawa-Harada C, Fukuda M, Fukuda MN


A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice.
J Nutr Biochem,85:108460 2020
Author:Diao P, Wang X, Jia F, Kimura T, Hu X, Shirotori S, Nakamura I, Sato Y, Nakayama J, Moriya K, Koike K, Gonzalez FJ, Aoyama T, Tanaka N


Diffuse MIST1 expression and decreased α1,4-linked N-acetylgludosamine (αGlcNAc) glycosylation on MUC6 are distinct hallmarks for gastric neoplasms showing oxyntic gland differentiation.
Histopathology ,77:413-422 2020
Author:Yamada S, Yamanoi K, Sato Y, Nakayama J


Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation.
FASEB J,34:9594-9614 2020
Author:Wang Y, Nakajima T, Diao P, Yamada Y, Nakamura K, Nakayama J, Tanaka N, Aoyama T, Kamijo Y


Dietary restriction suppresses steatosis-associated hepatic tumorigenesis in HCV core gene transgenic mice.
Liver Cancer ,9:529-548 2020
Author:Jia F, Diao P, Wang X, Hu X, Kimura T, Nakamuta M, Nakamura I, Shirotori S, Sato Y, Nakayama J, Moriya K, Koike K, Gonzalez FJ, Aoyama T, Naoki Tanaka N


Cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice depends on cecum-specific mitogen-activated protein kinase pathway activation and inflammation.
Am J Pathol ,190:453-468 2020
Author:Matoba H, Takamoto M, Fujii C, Kawakubo M, Kasuga E, Matsumura T, Natori T, Misawa K, Taniguchi S, Nakayama J


A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice.
Carcinogenesis,41:159-170 2020
Author:Hu X, Wang X, Jia F, Tanaka N, Kimura T, Nakajima T, Sato Y, Moriya K, Koike K, Gonzalez FJ, Nakayama J, Aoyama T


Tumor-suppressing potential of stingless bee propolis in in vitro and in vivo models of differentiated-type gastric adenocarcinoma.
Sci Rep,9:19635 2019
Author:Desamero MJ, Kakuta S, Tang Y, Chambers JK, Uchida K, Estacio MA, Cervancia C, Kominami Y, Ushio H, Nakayama J, Nakayama H, Kyuwa S


αGlcNAc and its catalyst α4GnT are diagnostic and prognostic markers in uterine cervical tumor, gastric type.
Sci Rep,9:13043 2019
Author:Ida K, Yamanoi K, Asaka S, Takeuchi H, Miyamoto T, Shiozawa T, Nakayama J


TAK1 safeguards macrophages against proinflammatory cell death.
J Immunol,203:783-788 2019
Author:Sanjo H, Nakayama J, Yoshizawa T, Fehling HJ, Akira S, Taki S


Analysis of A4gnt knockout mice reveals an essential role for gastric sulfomucins in preventing gastritis cystica profunda.
J Histochem Cytochem,67:759-770 2019
Author:Kawakubo M, Komura H, Goso Y, Okumura M, Sato Y, Fujii C, Miyashita M, Arisaka N, Harumiya S, Yamanoi K, Yamada S, Kakuta S, Kawashima H, Fukuda MN, Fukuda M, Nakayama J


A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice.
Arch Toxicol,93:1713-1725 2019
Author:Wang X, Tanaka N, Hu X, Kimura T, Lu Y, Jia F, Sato Y, Nakayama J, Moriya K, Koike, K, Aoyama T


Structural alteration of glycosaminoglycan side chains and spatial disorganization of collagen networks in the skin of patients with mcEDS-CHST14.
Biochim Biophys Acta Gen Subj,1863:623-631 2019
Author:Hirose T, Takahashi N, Tangkawattana P, Minaguchi J, Mizumoto S, Yamada S, Miyake N, Hayashi S, Hatamochi A, Nakayama J, Yamaguchi T, Hashimoto A, Nomura Y, Takehana K, Kosho T, Watanabe T


Annexin A1 expression is correlated with malignant potential of renal cell carcinoma.
Int J Urol,26:284-290 2019
Author:Yamanoi M, Fujii C, Yamanoi K, Fukuda MN, Nakayama J


Spinal manifestations in 12 patients with musculocontractural Ehlers-Danlos syndrome caused by CHST14/D4ST1 deficiency (mcEDS-CHST14).
Am J Med Genet,176A:2331-2341 2018
Author:Uehara M, Kosho T, Yamamoto N, Takahashi HE, Shimakura T, Nakayama J, Kato H, Takahashi J


Gastric gland mucin-specific O-glycan expression decreases as tumor cells progress from lobular endocervical gland hyperplasia to cervical mucinous carcinoma, gastric type.
Virchows Arch,473:305-311 2018
Author:Yamanoi K, Ishii K, Tsukamoto M, Asaka S, Nakayama J


Reduced αGlcNAc glycosylation on gastric gland mucin is a biomarker of malignant potential for gastric cancer, Barrett’s adenocarcinoma, and pancreatic cancer.
Histochem Cell Biol,149:569-575 2018
Author:Yamanoi K, Nakayama J


Upregulated expression of La ribonucleoprotein domain family member 6 and collagen type I gene following water-filtered broad-spectrum near-infrared irradiation in a 3-dimensional human epidermal tissue culture model as revealed by microarray analysis.
Australas J Dermatol,59:e87-e92 2018
Author:Tanaka Y, Nakayama J


Orally administrated brown seaweed-derived β-glucan effectively restrained development of gastric dysplasia in A4gnt KO mice that spontenously develop gastric adenocarcinoma.
Int Immunopharmacol,60:211-220 2018
Author:Desamero MJ, Kakuta S, Chambers JK, Uchida K, Hachimura S, Takamoto M, Nakayama J, Nakayama H, Kyuwa S


Increased expression of Y-box-binding protein-1 in hind-limb muscles during regeneration from ischemic injury in mice.
Tohoku J Exp Med ,244:53-62 2018
Author:Fuke M, Narita M, Wada Y, Seto T, Okada K, Nakayama J, Izumi H, Ito K-i


Pulmonary adenocarcinoma possibly developed from the cut-end of small-sized adenocarcinoma in the lung periphery as recurrence 13 years after its wedge resection.
Surg Case Rep,4:2 2018
Author:Hanaoka T, Kurai M, Okada M, Ishizone S, Karasawa F, Iizuka A, Ikeyama M, Nakayama J


Osteosarcoma arising in fibrous dysplasia, confirmed by mutational analysis of GNAS gene.
Pathol Res Pract ,214:318-324 2018
Author:Sugiura Y, Kanda H, Motoi N, Nomura K, Inamura K, Okada E, Matsumoto H, Shimoji T, Matsumoto S, Nakayama J, Takazawa Y, Ishikawa Y, Machinami R


Vascular abnormalities in the placenta of Chst14-/- fetuses: implications in the pathophysiology of perinatal lethality of the murine model and vascular lesions in human CHST14/D4ST1 deficiency.
Glycobiology ,28:80-89 2018
Author:Yoshizawa T, Mizumoto S, Takahashi Y, Shimada S, Sugahara K, Nakayama J, Takeda S, Nomura Y, Nitahara-Kasahara Y, Okada T, Matsumoto K, Yamada S, Kosho T


Cholesterol-α-glucosyltransferase gene is present in most Helicobacter species including gastric non-Helicobacter pylori helicobacters obtained from Japanese patients.
Helicobacter ,23:e12449 2018
Author:Kawakubo M, Horiuchi K, Matsumoto T, Nakayama J, Akamatsu T, Katsuyama T, Ota H, Sagara J


Reversion-Inducing cysteine-rich protein with Kazal motifs (RECK) in angiogenesis of microvessels in glioblastoma.
J Clin Mol Pathol ,1:No.2:12 2017
Author:Kanaya K, Sakai K, Hongo K, Fukushima M, Kawakubo M, Nakayama J


Interleukin-17A-deficient mice are highly susceptible to Toxoplasma gondii infection due to excessively induced T. gondii HSP70 and interferon gamma poduction.
Infect Immun,85:e00399-17 2017
Author:Moroda M, Takamoto M, Iwakura Y, Nakayama J, Aosai F


Cloning of Helicobacter suis cholesterol α-glucosyltransferase and production of an antibody capable of detecting it in formalin-fixed, paraffin-embedded gastric tissue sections.
Histochem Cell Biol ,148:463-471 2017
Author:Kawakubo M, Horiuchi K, Komura H, Sato Y, Kato M, Ikeyama M, Fukushima M, Yamada S, Ishizone S, Matsumoto T, Ota H, Sagara J, Nakayama J


Gastric gland mucin-specific O-glycan expression decreases with tumor progression from precursor lesions to pancreatic cancer.
Cancer Sci ,108:1897-1902 2017
Author:Ohya A, Yamanoi K, Shimojo H, Fujii C, Nakayama J


Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature.
BMC Cancer ,17:368 2017
Author:Yoshizawa J, Ishizone S, Ikeyama M, Nakayama J


Adenocarcinoma of Barrett’s esophagus in a dog.
J Toxicol Pathol ,30:239-243 2017
Author:Chambers JK, Saito T, Fukushima K, Kakuta S, Nakayama J, Ohno K, Tsujimoto H, Nakayama H, Uchida K


Potential involvement of chondroitin sulfate A in the pathogenesis of ameloblastoma.
Acta Histochem,119:439-445 2017
Author:Li X, Kurita H, Xiao T, Iijima K, Kurashina K, Nakayama J


High expression of ADAM10 predicts a poor prognosis for patients with glioblastoma
Int J Clin Exp Pathol,10(1):618-624 2017
Author:Kanaya K, Sakai K, Hongo K, Fukushima M, Kawakubo M, Nakayama J


The ROS-generating oxidase Nox1 is required for epithelial restitution following colitis
Exp Anim ,65:197-205 2016
Author:Kato M, Marumo M, Nakayama J, Matsumoto M, Yabe-Nishimura C, Kamata T


Enhanced expression of fibroblast growth factor receptor 3 IIIc promotes human esophageal carcinoma cell proliferation
J Histochem Cytochem,64(1):7-17 2016
Author:Ueno N, Shimizu A, Kanai M, Iwaya Y, Nakayama J, Seo MK


Chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance
Hum Pathol ,50:15-23 2016
Author:Momose T, Yoshimura Y, Harumiya S, Isobe K, Kito M, Fukushima M, Kato H, Nakayama J


Axonal TDP-43 aggregates in sporadic amyotrophic lateral sclerosis.
Neuropathol Appl Neurobiol,42(6):561-572 2016
Author:Onozato T, Nakahara A, Suzuki-Kouyama E, Hineno A, Yasude T, Nakamura T, Yahikozawa H, Watanabe M, Kayanuma K, Makishita H, Ohara S, Hashimoto T, Higuchi K, Sakai T, Asano K, Hashimoto T, Kanno H, Nakayama J, Oyanagi K


Up-regulated epidermal growth factor receptor expression following near-infrared irradiation simulating solar radiation in a 3-dimensional reconstructed human corneal epithelial tissue culture model
Clin Interv Aging,11:1027-1033 2016
Author:Tanaka Y, Nakayama J


Unexpected occurrence of fetal hemophagocytic syndrome in a patient with hereditary diffuse leukoencephalopathy with spheroids
Case Rep Clin Med,5:77-84 2016
Author:Kondo Y, Kinoshita M, Yoshida T, Matoba H, Uehara T, Ikeyama M, Nakayama J, Yoshida K, Ikeda S-i


Nox4-generated ROS Regulate TGF-β1-induced Motility of Colon Cancer Cells through the Low Molecular Weight Protein Tyrosine Phosphatase-Rho Signaling Pathway
信州医学雑誌,63(5):281-293 2015(Oct. 10)
Author:Zhang Y, Nakayama J, Kamata T


Decreased expression of gastric gland mucin-specific glycan α1,4-linked N-acetylglucosamine on its scaffold mucin 6 is associated with malignant potential of pyloric gland adenoma of the stomach
Histopathology ,67(6):898-904 2015
Author:Yamanoi K, Sekine S, Higuchi K, Kushima R, Nakayama J


Malignant meningioma with adenocarcinoma-like metaplasia: Demonstration of intestinal phenotype
Neuropathology ,35(2):158-164 2015
Author:Takayama Y, Nobusawa S, Ochiai I, Watanabe H, Ishigame H, Ikota H, Hirato J, Nakayama J, Yokoo H


Reduced gland mucin-specific O-glycan in gastric atrophy: A possible risk factor for differentiated-type adenocarcinoma of the stomach
J Gastroenterol Hepatol ,30(10):1478-1484 2015
Author:Yamada S, Okamura T, Kobayashi S, Tanaka E, Nakayama J


Breast metastases of gastric signet-ring cell carcinoma: a report of two cases and review of the literature
OncoTargets Ther,8:91-97 2015
Author:Iesato A, Oba T, Ono M, Hanamura T, Watanabe T, Ito T, Kanai T, Maeno K, Ishizaka K, Kitabatake H, Takeuchi D, Suzuki A, Nakayama J, Ito K


Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites
Proc Natl Acad Sci USA,111(22):8173-8178 2014
Author:Nonaka M, Bao X, Matsumura F, Götze S, Kandasamy J, Kononov A, Broide DH, Nakayama J, Seeberger PH, Fukuda M


Loss of gastric gland mucin-specific O-glycan is significantly associated with progression of differentiated-type adenocarcinoma of the stomach
Cancer Sci,105:126-133 2014
Author:Shiratsu K, Higuchi K, Nakayama J


Reduced expression of αGlcNAc in Barrett’s esophagus adjacent to Barrett’s adenocarcinoma - Possible biomarker to predict the malignant potential of Barrett’s esophagus –
Histopathology,64:536-546 2014
Author:Iwaya Y, Hasebe O, Koide N, Kitahara K, Suga T, Shinji A, Muraki T, Yokosawa S, Yamada S, Arakura N, Tanaka E, Nakayama J


Dual roles of gastric gland mucin-specific O-glycans in prevention of gastric cancer
Acta Histochem Cytochem,47(1):1-9 2014
Author:Nakayama J


Defect of suppression of inflammasome-independent interleukin-8 secretion from SW982 synovial sarcoma cells by familial Mediterranean fever-derived pyrin mutations
Mol Biol Rep,41:545-553 2014
Author:Sugiyama R, Agematsu K, Migita K, Nakayama J, Mokuda S, Ogura F, Haraikawa K, Okumura C, Suehiro S, Morikawa S, Ito Y, Masumoto J


Gliomatosis encephali” as a novel category of brain tumors by the first autopsy case report of gliomatosis cerebelli
Neuropathology,34(3):295-303 2014
Author:Nakahara A, Yoshida T, Yazawa M, Ehara T, Nakayama J, Kakita A, Ogura R, Asakawa M, Suzuki-Kouyama E, Oyanagi K


Overexpression of O-GlcNAc by prostate cancer cells is significantly associated with poor prognosis of patients
Prostate Cancer Prost Dis,17:18-22 2014
Author:Kamigaito T, Okaneya T, Shimojo H, Nishizawa O, Nakayama J


Development of pro-apoptotic peptides as potential therapy for peritoneal endometriosis
Nat Commun,5:4478 2014
Author:Sugihara K, Kobayashi Y, Suzuki A, Tamura N, Motamedchaboki K, Huang C-T, Akama T, Pecotte J, Frost P, Bauer C, Jimenez J, Nakayama J, Aoki D, Fukuda MN


In vivo regulation of steroid hormones by the chst10 sulfotransferase in mouse
J Biol Chem,288:5007-5016 2013
Author:Suzuki-Anekoji M, Suzuki A, Wu S-W, Angata K, Murai K, Sugihara K, Akama TO, Khoo K-H, Nakayama J, Fukuda MN, Fukuda M


Immunohistochemical expression of core2 β1-6 N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid type of endometrial carcinoma: a novel potential prognostic factor
Histopathology,62(7):986-993 2013
Author:Miyamoto T, Suzuki A, Asaka R, Ishikawa, Yamada Y, Kobara H, Nakayama J, Shiozawa T


Primary malignant sarcomatoid mesothelioma in the pericardium
Intern Med,52(2):249-253 2013
Author:Tateishi K, Ikeda M, Yokoyama T, Urushihata K, Yamamoto H, Hanaoka M, Kubo K, Sakai Y, Nakayama J, Koizumi T


Lymphocyte recruitment via high endothelial venules in lymphoid stroma of Warthin's tumour
Pathology,45(2):150-154 2013
Author:Ohya A, Kobayashi M, Sakai Y, Kawashima H, Kageyama S, Nakayama J


Periductal induction of high endothelial venule-like vessels in type 1 autoimmune pancreatitis
Pancreas,42(1):53-59 2013
Author:Maruyama M, Kobayashi M, Sakai Y, Hiraoka N, Oya A, Kageyama S, Tanaka E, Nakayama J, Morohoshi T


High levels of FOXP3+ regulatory T cells in gastric MALT lymphoma predicts responsiveness to Helicobacter pylori eradication
Helicobacter,18(5):356-362 2013
Author:Iwaya Y, Kobayashi M, Momose M, Hiraoka N, Sakai Y, Akamatsu T, Tanaka E, Ohtani H, Fukuda M, Nakayama J


Helicobacter pylori cholesteryl α-glucosides contribute to its pathogenicity and immune response by natural killer T cells
PLoS One,8(12):e78191 2013
Author:Ito Y, Vela JL, Matsumura F, Hoshino H, Tyznik A, Lee H, Girardi E, Zajonc DM, Liddington, Kobayashi M, Bao X, Bugaytsova J, Borén T, Jin R, Zong Y, Seeberger PH, Nakayama J, Kronenberg M, Fukuda M


Crucial role of hyaluronan in neointimal formation after vascular injury
PLoS One,8(3):e58760 2013
Author:Kashima Y, Takahashi M, Shiba Y, Itano N, Izawa A, Koyama J, Nakayama J, Taniguchi S, Kimata K, Ikeda U


Role of GalNAc4S-6ST in astrocytic tumor progression
PLoS One,8:e54278 2013
Author:Kobayashi T, Yan H, Kurahashi Y, Ito Y, Maeda H, Tada T, Hongo K, Nakayama J


Essential role of gastric gland mucin in preventing gastric cancer in mice
J Clin Invest,122(3):923-934 2012
Author:Karasawa F, Shiota A, Goso Y, Kobayashi M, Sato Y, Masumoto J, Fujiwara M, Yokosawa S, Muraki T, Miyagawa S, Ueda M, Fukuda MN, Fukuda M, Ishihara K, Nakayama J


Non-thermal DNA damage of cancer cells using near-infrared irradiation
Cancer Sci,103(8):1467-1473 2012
Author:Tanaka Y, Tatewaki N, Nishida H, Eitsuka T, Ikekawa N, Nakayama J


Expression of long-form N-acetylglucosamine-6-O-sulfotransferase 1 in human high endothelial venules
J Histochem Cytochem,60(5):397-407 2012
Author:Fujiwara M, Kobayashi M, Hoshino H, Uchimura K, Nakada T, Masumoto J, Sakai Y, Fukuda M, Nakayama J


Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases
Semin Immunopathol,34:401-413 2012
Author:Kobayashi M, Hoshino H, Suzawa K, Sakai Y, Nakayama J, Fukuda M


Glycoside hydrolase family 89 α-N-acetylglucosaminidase from Clostridium perfringens specifically acts on GlcNAcα 1,4Galβ1R at the non-reducing terminus of O-glycans in gastric mucin
J Biol Chem,286(8):6479-6489 2011
Author:Fujita M, Tsuchida A, Hirata A, Kobayashi N, Goto K, Osumi K, Hirose Y, Nakayama J, Yamanoi T, Ashida H, Mizuno K


HNK-1 glycan functions as a tumor suppressor for astrocytic tumor
J Biol Chem,286(37):32824-32833 2011
Author:Suzuki M, Suzuki M, Kobayashi T, Sato Y, Nakayama J, Suzuki A, Bao X, Angata K, Fukuda M


O-Glycans carrying non-sulfated sialyl Lewis X appearing on HEV-like vessels in gastric MALT lymphoma function as L-selectin ligands
J Pathol,224:67-77 2011
Author:Kobayashi M, MitomaJ, Hoshino H, Yu SY, Shimojo Y, Suzawa K, Khoo KH, Fukuda M, Nakayama J


Inflammasome activation of cardiac fibroblasts is effential for myocardial ischemia/reperfusion injury
Circulation,123:594-604 2011
Author:Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U


Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide
Proc Natl Acad Sci USA,108(49):19587–19592 2011
Author:Hatakeyama S, Sugihara K, Shibata TK, Nakayama J, Akama TO, Tamura N, Wong S, Bobkov AA, Takano Y, Ohyama C, Fukuda M, Fukuda MN


Reduced glycosylation of α-dystroglycans on carcinoma cells contributes to formation of highly infiltrative histological patterns in prostate cancer
Prostate,71:1151-1157 2011
Author:Shimojo H, Kobayashi M, Kamigaito T, Shimojo Y, Fukuda M, Nakayama J


Membrane-associated activation of cholesterol α-glucosyltransferase, an enzyme responsible for biosynthesis of cholesteryl-α-D-glucopyranoside in Helicobacter pylori critical for its survival
J Histochem Cytochem,59(1):98-105 2011
Author:Hoshino H, Tsuchida A, Kametani K, Mori M, Nishizawa T, Suzuki T, Nakamura H, Lee H, Ito Y, Kobayashi M, Masumoto J, Fujita M, Fukuda M, Nakayama J


An integrin α4β7•IgG heterodimeric chimera binds to MAdCAM-1 on high endothelial venules in gut-associated lymphoid tissue
J Histochem Cytochem,59:572-583 2011
Author:Hoshino H, Kobayashi M, Mitoma J, Sato Y, Fukuda M, Nakayama J


A rare lung nodule consisting of adenocarcinoma and amyloid deposition in a patient with primary systemic AL amyloidosis
Inter Med,50:243-246 2011
Author:Miyazaki D, Yazaki M, Ishii W, Matsuda M, Hoshii Y, Nara K, Nakayama J, Ikeda S


Gliosarcoma arising from a fibrillary astrocytoma
J Clin Neurosci,18(9):1251-1254 2011
Author:Kobayashi T, Sakai K, Tada T, Sekiguchi Y, Hara Y, Kodama K, Goto T, Tanaka Y, Sano K, Nakayama J, Hongo K


COP35, a cholangiocarcinoma-binding oligo-peptide, interacts with the clathrin heavy chain accompanied by GRP78
Mol Cancer Res,9(6):688-701 2011
Author:Kitahara H, Masumoto J, Parker AL, Maruta F, Kubo N, Shimizu A, Akita N, Miwa S, Kobayashi N, Nakayama J, Miyagawa S


Core2 O-glycan structure functions in gastrointestinal cell differentiation by regulating cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV
J Biol Chem,285(48):37683-37692 2010
Author:Lee SH, Yu SY, Nakayama J, Khoo KH, Stone EL, Fukuda M, Marth JD, Fukuda M


Non-thermal cytocidal effect of infrared irradiation on cultured cancer cells using specialized device
Cancer Sci,101(6):1396-1402 2010
Author:Tanaka, Yohei; Matsuo, Kiyoshi;Yuzuriha, Shunsuke; Yan, Huimin; Nakayama, Jun


Selective alpha(1A)-Adrenoceptor Stimulation Induces Mueller's Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation
CURRENT EYE RESEARCH,35(5):363-369 2010
Author:Yano, Shiharu; Hirose, Masamichi; Nakada, Tsutomu; Nakayama, Jun; Matsuo, Kiyoshi; Yamada, Mitsuhiko


Reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase-9 are prognostic markers in skull base chordomas
NEUROSURGICAL REVIEW,33(2):167-173 2010
Author:Rahmah, Nunung Nur; Sakai, Keiichi; Nakayama, Jun; Hongo, Kazuhiro


Nasu-Hakola disease: The first case reported by Nasu and review
Neuropathology,30(5):463-470 2010
Author:Kaneko M, Sano K, Nakayama J, Amano N


Identification of mRNA splicing factor as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells
Proc Natl Acad Sci USA,106(9):3095-3100 2009
Author:Hatakeyama S, Sugihara K, Nakayama J, Akama TO, Wong SA, Kawashima H, Zhang J, Smith DF, Ohyama C, Fukuda M, Fukuda MN


Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase
Proc Natl Acad Sci USA,106:12109-12114 2009
Author:Bao X, Kobayashi M, Hatakeyama S, Angata K, Gullberg D, Nakayama J, Fukuda MN, Fukuda M


Therapeutic and preventive effects of methotrexate on zymosan-induced arthritis in SKG mice
J Vet Med Sci,71:713-717 2009
Author:Nagate T, Kawai J, Nakayama J


Role of sulfated O-glycans expressed by high endothelial venule-like vessels in pathogenesis of chronic inflammatory gastrointestinaldiseases
BIOLOGICAL & PHARMACEUTICAL BULLETIN,32(5):774-779 2009
Author:Kobayashi, Motohiro; Fukuda, Minoru; Nakayama, Jun


Antigen p57/Kip2 as a potential negative regulator of human astrocytoma growth
JOURNAL OF CLINICAL NEUROSCIENCE,16(12):1615-1618 2009
Author:Akaishi, Kotaro; Nakayama, Jun; Sakai, Keiichi; Kobayashi, Tatsuya; Rutka, James T.


Trophinin: what embryo implantation teaches us about human cancer
Cancer Biol Ther,7:1165-1170 2008
Author:Fukuda MN, Sugihara K, Nakayama J


Immunohistochemical demonstration of proliferating lymphatic vessels in colorectal carcinoma and its clinicopathological significance
Cancer Lett,246(42737):167-172 2007
Author:Omachi T, Kawai Y, Mizuno R, Nomiyama T, Miyagawa S, Ohhashi T, Nakayama J


The role of trophinin, an adhesion molecule unique to human trophoblasts, in progression of colorectal cancer
Int J Cancer,121(5):1072-1078 2007
Author:Harada O, Suga T, Suzuki T, Nakamoto K, Kobayashi M, Nomiyama T, Nadano D, Ohyama C, Fukuda MN, Nakayama J


Preferential induction of peripheral lymph node addressin on high endothelial venule-like vessels in the active phase of ulcerative colitis
Am J Gastroenterol,102:1499-1509 2007
Author:Suzawa K, Kobayashi M, Sakai Y, Hoshino H, Watanabe M, Harada O, Ohtani H, Fukuda M, Nakayama J


The utility of formalin-fixed and paraffin-embedded tissue blocks for quantitative analysis of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase mRNA expressed by colorectal cancer cells
Acta Histochem Cytochem,40(2):53-59 2007
Author:Ito Y, Watanabe M, Nishizawa T, Omachi T, Kobayashi T, Habuchi O, Nakayama J:


RNA interference-mediated knock-down of transient receptor potential vanilloid 1 prevents forepaw inflammatory hyperalgesia in rat
Eur J Neurosci,25:2956-2963 2007
Author:Kasama S, Kawakubo M, Suzuki T, Nishizawa T, Ishida A, Nakayama J


Comparison of the histological and immunohistochemical features of the thymus in young- and elderly-onset myasthenia gravis without thymoma
J Clin Neurosci,14(2):110-115 2007
Author:Ishii, W; Matsuda, M; Hanyuda, M; Momose, M; Nakayama, J; Ehara, T; Ikeda, S


Prognositic significance of the immunohistochemical staining of cleaved-caspase-3, an activated-form of caspase-3, in gliomas
Clin Cancer Res,13(13):3868-3874 2007
Author:Kobayashi T, Masumoto J, Tada T, Nomiyama T, Hongo K, Nakayama J


Expression profiling of glycosyltransferases and related enzymes using in situ hybridization
Methods Enzymol,416:120-129 2006
Author:Nakayama J, Suzuki M, Suzuki M, Fukuda M


Expression cloning of cholesterol alpha-glucosyltransferase, a unique enzyme that can be inhibited by natural antibiotic gastric mucin O-glycans, from Helicobacter pylori
Biochem Biophys Res Commun,349(4):1235-1241 2006
Author:Lee, H; Kobayashi, M; Wang, P; Nakayama, J; Seeberger, PH; Fukuda, M


Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat
J Clin Invest,116(2):395-404 2006
Author:Mori, M; Li, GX; Abe, I; Nakayama, J; Guo, ZJ; Sawashita, J; Ugawa, T; Nishizono, S; Serikawa, T; Higuchi, K; Shumiya, S


Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O-sulfotransferase
Proc Natl Acad Sci USA,103(36):13333-13338 2006
Author:Hayashida, Y; Akama, TO; Beecher, N; Lewis, P; Young, RD;Meek, KM; Kerr, B; Hughes, CE; Caterson, B; Tanigami, A; Nakayama, J; Fukada, MN; Tano, Y; Nishida, K; Quantock, AJ


Essential and mutually compensatory roles of alpha-mannosidase II and alpha-mannosidase IIx in N-glycan processing in vivo in mice
Proc Natl Acad Sci USA,103(24):8983-8988 2006
Author:Akama, TO; Nakagawa, H; Wong, NK; Sutton-Smith, M; Dell, A; Morris, HR; Nakayama, J; Nishimura, SI; Pai, A; Moremen, KW; Marth, JD; Fukuda, MN


Rotigaptide (ZP123) improves atrial conduction slowing in chronic volume overload-induced dilated atria
Basic Clin Pharmacol Toxicol,99(1):71-79 2006
Author:Haugan, K; Miyamoto, T; Takeishi, Y; Kubota, I; Nakayama, J; Shimojo, H; Hirose, M


Identification of oligopeptides binding to peritoneal tumors of gastric cancer
Cancer Sci,97(10):1075-1081 2006
Author:Akita, N; Maruta, F; Seymour, LW; Kerr, DJ; Parker, AL; Asai, T; Oku, N; Nakayama, J; Miyagawa, S


Clinical utility of quantitative RT-PCR targeted to alpha 1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer
Cancer Sci,97(2):119-126 2006
Author:Ishizone, S; Yamauchi, K; Kawa, S; Suzuki, T; Shimizu, F; Harada, O; Sugiyama, A; Miyagawa, S; Fukuda, M; Nakayama, J


Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer
Cancer Res,66(12):6210-6218 2006
Author:Machida, EO; Brock, MV; Hooker, CM; Nakayama, J; Ishida, A; Amano, J; Picchi, MA; Belinsky, SA; Herman, JG; Taniguchi, S; Baylin, SB


Female adnexal tumor of probable wolffian origin: Morphological, immunohistochemical, and ultrastructural study with c-kit gene analysis
Pathol Int,56(2):95-100 2006
Author:Harada, O; Ota, H; Takagi, K; Matsuura, H; Hidaka, E; Nakayama, J


Terminal alpha 1,4-linked N-acetylglucosamine in Helicobacter pylori-associated intestinal metaplasia of the human stomach and gastric carcinoma cell lines
J Histochem Cytochem,54(5):585-591 2006
Author:Ferreira, B; Marcos, NT; David, L; Nakayama, J; Reis, CA


Efficacy of S-1 for patients with peritoneal metastasis of gastric cancer
Chemotherapy,52(6):301-307 2006
Author:Ishizone, S; Maruta, F; Saito, H; Koide, N; Sugiyama, A; Nakayama, J; Miyagawa, S


Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells
Oncogene,25(26):3699-3707 2006
Author:Mochizuki, T; Furuta, S; Mitsushita, J; Shang, W; Ito, M; Yokoo, Y; Yamaura, M; Ishizone, S; Nakayama, J; Konagai, A; Hirose, K; Kiyosawa,K; Kamata, T


Efficacy of mycophenolic acid combined with KRP-203, a novel immunomodulator, in a rat heart transplantation model
J Heart Lung Transpl,25(3):302-309 2006
Author:Suzuki, C; Takahashi, M; Morimoto, H; Izawa, A; Ise, H; Fujishiro, J; Murakami, T; Ishiyama, J; Nakada, A; Nakayama, J; Shimada, K; Ikeda, U; Kobayashi, E


Expression of Fas ligand by hepatic macrophages in patients with fulminant hepatic failure
Am J Gastroenterol,100(11):2551-2559 2005
Author:Mita A, Hashikura Y, Tagawa Y-i, Nakayama J, Kawakubo M, Miyagawa S


Malignant myoepithelioma (myoepithelial carcinoma) of soft tissue
Pathol Int,55(8):510-513 2005
Author:Harada O, Ota H, Nakayama J


Arachidonic acid-induced COX-1 and COX-2-mediated vasodilation in rat gingival arterioles in vivo
Jpn J Physiol,55(5):293-302 2005
Author:Nakatsuka A, Mizuno R, Ono N, Nakayama J, Ohhashi T


Crucial roles of mesodermal cell lineages in a murine embryonic stem cell-derived in vitro liver organogenesis system
Stem Cells,23(7):903-913 2005
Author:Ogawa S, Tagawa Y, Kamiyoshi A, SuzukiA, Nakayama J, Hashikura Y, Miyagawa S


MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats
Transpl Int,18(7):844-853 2005
Author:Suzuki F, Hashikura Y, Ise H, Ishida A, Nakayama J, Takahashi M,Miyagawa S, Ikeda U


Expression of core 2 beta 1,6-N-acetylglucosaminyltransferase facilitates prostate cancer progression
Glycobiology,15(10):1016-1024 2005
Author:Hagisawa S, Ohyama C, Takahashi T, Endoh M, Moriya T, Nakayama J, Arai Y, Fukuda M


Polysialic acid facilitates tumor invasion by glioma cells
Glycobiology,15(9):887-894 2005
Author:Suzuki M, Suzuki M, Nakayama J, Suzuki A, Angata K, Chen S, Sakai K, Hagihara K, Yamaguchi Y, Fukuda M


N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules
Nat Immunol,6(11):1096-1104 2005
Author:Kawashima H, Petryniak B, Hiraoka N, Mitoma J, Huckaby V, Nakayama J, Uchimura K, Kadomatsu K, Muramatsu T, Lowe JB, Fukuda M


Molecular cloning and expression of HRLRRP, a novel heart-restricted leucine-rich repeat protein
Biochem Biophys Res Commun,314(4):1086-1092 2004
Author:Nakane T, Satoh T, Inada Y, Nakayama J, Itoh E Chiba S


Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection
Science,305(5686):1003-1006 2004
Author:Kawakubo M, Ito Y, Okimura Y, Kobayashi M, Sakura K, Kasama S, Fukuda MN, Fukuda M, Katsuyama T, Nakayama J


Core 2 branching β1,6-N-acetylglucosaminyltransferase and heig endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homing
J Biol Chem,279(4):3058-3067 2004
Author:Hiraoka N, Kawashima H, Petryniak B, Nakayama J, Mitoma J, Marth JD, Lowe JB, Fukuda M


Induction of peripheral lymph node addressin in human gastric mucosa infected by Helicobacter pylori
Proc Natl Acad Sci USA,101(51):17807-17812 2004
Author:Kobayashi M, Mitoma J, Nakamura N, Katsuyama T, Nakayama J, Fukuda M


Inducible expression of p57KIP2 inhibits glioma cell motility and invasion
J Neurooncol,68(3):217-223 2004
Author:Sakai K, Peraud A, Mainprize T,Nakayama J, Tsugu A, Hongo K, Kobayashi S, Rutka JT T, Rutka


Functional correlation of trophinin expression with the malignancy of testicular germ cell tumor
Cancer Res,64(12):4257-4262 2004
Author:Hatakeyama S, Ohyama C, Minagawa S, Inoue T, Kakinuma H, Kyan A, Arai Y, Suga T, Nakayama J, Kato T, Habuchi T, Fukuda MN


Symmetric Dumbbell Ganglioneuromas of Bilateral C2 and C3 Roots with Intradural Extension Associated with Von Recklinghausen's Disease:Case Report
Surg Neurol,61(5):468-473 2004
Author:Kyoshima K, Sakai K, Kanaji M, Oikawa S, Kobayashi S, Sato A, Nakayama J


Pulmonary lymphoepithelioma-like carcinoma: predominant infiltration of tumor-associated cytotoxic Tlymphocytes might represent the enhanced tumor immunity
Intern Med,43(4):323-326 2004
Author:Kobayashi M, Ito M, Sano K, Honda T, Nakayama J


Degenerative thalamic hamartoma: CT and MR imaging features
Am J Neuroradiol,25(5):766-768 2004
Author:Kaneko T, Kawakami R, Fujinaga Y, Oguchi K, Nakayama J, Hongo K, Kadoya M


Polysialic acid and HNK-1 are expressed in the adult rat vestibular endorgans
Neuroreport,15(10):1575-1578 2004
Author:Isawa M, Takumi Y, Hashimoto S, Nakayama J, Usami S


A subtype of human gastric mucins expressing alpha1,4-GlcNAc-capped O-glycans functions as a natural antibiotic against Helicobacter pylori infection
GLYCOBIOLOGY,14(11):1073-1073 2004
Author:Nakayama, J; Kawakubo, M; Ito, Y; Kobayashi, M; Fukuda, MN; Fukuda, M; Katsuyama, T


Gross total surgical removal of malignant glioma from the medulla oblongata: report of two adult cases with reference to surgicalanatomy
J Clin Neurosci,11(1):75-80 2004
Author:Kyoshima K, Sakai K, Goto T, Tanabe A, Sato A, Nagashima H, Nakayama J


Polysialic acid and mucin type O-glycans on the neural cell adhesion molecule differentially regulate myoblast fusion
J Biol Chem,278(49):49459-49468 2003
Author:Suzuki, M; Angata, K; Nakayama, J; Fukuda, M


Implantation-dependent expression of trophinin by maternal Fallopian tube epithelia during tubal pregnancies: Possible role of human chorionic gonadotrophin on ectopic pregnancy
Am J Pathol,163(6):2211-2219 2003
Author:Nakayama J, Aoki D, Suga T, Akama T O, Ishizone S, Yamaguchi H, Imakawa K, Nadano D, Fazleabas A T, Katsuyama T, Nozawa S, Fukuda M N


Usefulness of the real-time reverse transcription-polymerase chain reaction assay targeted to alpha1,4-N-acetylglucosaminyltransferase for the detection of gastric cancer
Lab Invest,83(2):187-197 2003
Author:Shimizu F, Nakayama J, Ishizone S, Zhang M X, Kawakubo M, Ota H, Sugiyama A, Kawasaki S, Fukuda M, Katsuyama T


Life-threatening veno-occlusive disease after living-related liver transplantation
Transplantation,75(5):727-730 2003
Author:Nakazawa, Y; Chisuwa, H; Mita, A; Ikegami,T; Hashikura, Y; Terada, M; Nakayama, J; Kawasaki, S


Expression of gastric gland mucous cell-type mucin in normal and neoplastic human tissues
J Histochem Cytochem,51(12):1689-1698 2003
Author:Nakajima, K; Ota, H; Zhang, MX; Sano, K; Honda, T; Ishii, K; Nakayama, J


Immunohistochemical localization of hepatocyte growth factor activator (HGFA) in developing mouse liver tissues: Heterogeneous distribution of HGFA protein
J Histochem Cytochem,51(9):1139-1149 2003
Author:Iida, I; Johkura, K; Teng, RF; Kubota, S; Cui, L; Zhao, X; Ogiwara, N; Okouchi, Y; Asanuma, K; Nakayama, J; Sasaki, K


Differential expression of ribosomal proteins in human normal and neoplastic colorectum
J Histochem Cytochem,51(5):567-573 2003
Author:Kasai, H; Nadano, D; Hidaka, E; Higuchi, K; Kawakubo, M; Sato, TA; Nakayama, J


Purification and measurement of HDL3-binding proteins in human peripheral blood mononuclear cells
Ann Clin Lab Sci,33(3):271-278 2003
Author:Hidaka, H; Tozuka, M; Yamauchi, K; Ohta, H; Nakayama, J; Katsuyama, T


Temporal and spatial expression profiles of BMP receptors and Noggin during BMP-2-induced ectopic bone formation
J Bone Miner Res,18(10):1854-1862 2003
Author:Nakamura, Y; Wakitani, S; Nakayama, J; Wakabayashi, S; Horiuchi, H; Takaoka, K


Mouse model of N-acetylgalactosamine-6-sulfate sulfatase deficiency (Galns(-/-)) produced by targeted disruption of the gene defective in Morquio A disease
Hum Mol Genet,12(24):3349-3358 2003
Author:Tomatsu, S; Orii, KO; Vogler, C; Nakayama,J; Levy, B; Grubb, JH; Gutierrez, MA; Shim, S; Yamaguchi, S; Nishioka, T; Montano, AM; Noguchi, A; Orii, T; Kondo, N; Sly, WS


Helicobacter pylori infection up-regulates gland mucous cell-type mucins in gastric pyloric mucosa
Helicobacter,8(6):594-600 2003
Author:Matsuzawa M, Ota H, Hiyama M, Zhang MX, Sano K, Honda T, Ueno I, Akamatsu T, Nakayama J


a1,4-N-acetylglucosaminyltransferase and gastric cancer. Barrett JC, Imai K, Kakizoe T, Shively J E, and Yamaguchi K eds: Basic and Clinical Research on Tumor Markers
Extended Abstracts for the 32nd International Symposium of the Princess Takamatsu Cancer Research Fund,:61-65 2002
Author:Nakayama J, Shimizu F, Zhang MX, Fukuda M, Katsuyama T


a4-N-acetylglucosaminyltra- nsferase
Taniguchi N, Honke K, Fukuda M eds: Handbook of Glycosyltransferases and Related Genes,:151-157 2002
Author:Nakayama J


Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton
Biochem J,364:669-677 2002
Author:Nadano D, Nakayama J, Matsuzawa S, Sato T, Matsuda T, Fukuda MN


Significant differences between mouse and human trophinins are revealed by their expression patterns and targeted disruption of mouse trophinin gene
Biol Reprod,66(2):313-321 2002
Author:Nadano D, Sugihara K, Paria BC, Saburi S, Copeland NG, Gilbert DJ, Jenkins NA, Nakayama J, Fukuda MN


Sialyl Lewis X-dependent lung colonization of B16 melanoma cells through a selectin-like endothelial receptor distinct from E- or P-selectin
Cancer Res,62(15):4194-4198 2002
Author:Zhang J, Nakayama J, Ohyama C, Suzuki M, Suzuki A, Fukuda M, Fukuda M N


Association of GM4 ganglioside with the membrane surrounding lipid droplets in shark liver
J Lipid Res,43(7):1019-1025 2002
Author:Li Y-T, Sugiyama E, Ariga T, Nakayama J, Hayama M, Hama Y, Nakagawa H, Tai T, Maskos K, Li S-C, Kasama T


Anti-neovascular therapy using novel peptides homing to angiogenic vessels
Oncogene,21(17):2662-2669 2002
Author:Oku N, Asai T, Watanabe K, Kuromi K, Nagatsuka M, Kurohane K, Kikkawa H, Ogino K, Tanaka M, Ishikawa D, Tsukada H, Momose M, Nakayama J, Taki T


Evaluation of 5-S-cysteinyidopa as a markerof melanoma progression: 10 years' experience
MELANOMA RESEARCH,12(3):245-253 2002
Author:Wakamatsu, K; Kageshita, T; Furue, M; Hatta, N; Kiyohara, Y; Nakayama, J; Ono, T; Saida, T; Takata, M; Tsuchida, T; Uhara, H; Yamamoto, A; Yamazaki, N; Naito, A; Ito, S


Malignant astrocytoma of the conus medullaris treated by spinal cordectomy
J Clin Neurosci,9(2):211-216 2002
Author:Kyoshima K,Ito K, Tanabe A, Iwashita T, Goto T, Sato A, Nakayama J


Usefulness of albumin scintigraphyin a pediatric liver transplant recipient with gastrointestinal posttransplant lymphoproliferative disorder
Liver Transpl,8:568-569 2002
Author:Mita A, Hashikura Y, Momose M, Nakayama J, Sasaki E, Ikegami T, Nakazawa Y, Chisuwa H, Terada M, Kawasaki S


A novel endo-beta-galactosidase from Clostridium perfringens that liberates the disaccharide GlcNAc alpha 1,4Gal from glycans specifically expressed in the gastric gland mucous cell-type mucin
J Biol Chem,276(30):28226-28232 2001
Author:Ashida H, Anderson K, Nakayama J, Maskos K, Chou C-W, Cole R B, Li S-C, Li Y-T


Human corneal GlcNAc 6-O-sulfotransferase and mouse intestinal GlcNAc 6-O-sulfotransferase both produce keratan sulfate
J Biol Chem,276(19):16271-16278 2001
Author:Akama, TO; Nakayama, J; Nishida, K; Hiraoka, N; Suzuki, M; McAuliffe, J; Hindsgaul, O; Fukuda, M; Fukuda, MN


Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Galbeta1-3/1-4GlcNAc-R) oligosaccharides
J Biol Chem,276(1):267-274 2001
Author:Honke K, Tsuda M, KoyotaS, Wada Y, Iida-Tanaka N, Ishizuka I, Nakayama J, Taniguchi N


Cell lineage specificity of newly raised monoclonal antibodies against gastric mucins in normal, metaplastic, and neoplastic humantissues and their application to pathology diagnosis
Am J Clin Pathol,115(1):69-79 2001
Author:Ota, H; Hayama, M; Nakayama, J; Hidaka, H; Honda, T; Ishii, K; Fukushima, M; Uehara, T; Kurihara, M; Ishihara, K; Hotta, K; Katsuyama, T


Novel sulfated lymphocyte homing receptors and their control by a core1 extension beta1,3-N-acetylglucosaminyltransferase
Cell,105(7):957-969 2001
Author:Yeh J-C, Hiraoka N, Petryniak B, Nakayama J, Ellise L G, Rabuka D, Hindsgaul O, Marth J, Lowe J B, Fukuda M


Effect of polysialic acid on the tumor xenografts implanted into nude mice
Int J Cancer,94(2):192-199 2001
Author:Jimbo, T; Nakayama, J; Akahane, K; Fukuda, M


Fatal hemophagocytic syndrome after living-related liver transplantation - A report of two cases
Transplantation,72(11):1843-1846 2001
Author:Chisuwa, H; Hashikura, Y; Nakazawa, Y; Kamijo, T; Nakazawa, K; Nakayama, J; Oh-ishi, T; Ikegami, T; Terada, M; Kawasaki, S


Clinicopathological significance of core 2 beta1,6-N-acetylglucosaminyltransferase messenger RNA expressed in the pulmonary adenocarcinoma determined by in situ hybridization
Cancer Res,61(5):2226-2231 2001
Author:Machida E, Nakayama J, Amano J, Fukuda M


Prognostic significance of polysialic acid expression in resected non-small cell lung cancer
Cancer Res,61(4):1666-1670 2001
Author:Tanaka, F; Otake, Y; Nakagawa, T; Kawano, Y; Miyahara, R; Li, M; Yanagihara, K; Inui, K; Oyanagi, H; Yamada, T; Nakayama, J; Fujimoto, I; Ikenaka, K; Wada, H


Expression of apoptosis-associated speck-like protein containing a caspase recruitment domain, a pyrin N-terminal homology domain-containing protein, in normal human tissues
J Histochem Cytochem,49(10):1269-1275 2001
Author:Masumoto, J; Taniguchi, S; Nakayama, J; Shiohara, M; Hidaka, E; Katsuyama, T; Murase, S; Sagara, J


Extrahepatic expression of apolipoprotein A-II in mouse tissues: Possible contribution to mouse senile amyloidosis
J Histochem Cytochem,49(6):739-747 2001
Author:Fu, L; Matsuyama, I; Chiba, T; Xing, YM; Korenaga, T; Guo, ZJ; Fu, XY; Nakayama, J; Mori, M; Higuchi, K


Immunohistochemical demonstration od alpha,4-N-acetylglucosaminyltransferase that forms GlcNAc alpha 1,4Gal beta residues in human gastrointestinal mucosa
J Histochem Cytochem,49(5):587-596 2001
Author:Zhang, MX; Nakayama, J; Hidaka, E; Kubota, S; Yan, J; Ota, H; Fukuda, M


Helicobacter pylori and two ultrastructurally distinct layers of gastric mucous cell mucins in the surfacemucous gel layer
Gut,49(4):474-480 2001
Author:Hidaka, E; Ota, H; Hidaka, H; Hayama, M; Matsuzawa, K; Akamatsu, T; Nakayama, J; Katsuyama, T


Coexistence of gland mucous cell-type mucin and lysozyme in gastric gland mucous cells
Histochem Cell Biol,113(2):91-98 2000
Author:Hidaka, E; Ota, H; Katsuyama, T; Nakayama, J; Momose, M; Hidaka, H; Ishii, K; Murata, F; Tsuyama, S; Kurihara, M; Ishihara, K; Hotta, K


Proliferation-associated expression of the MEN1 gene as revealed by in situ hybridization: Possible role of the menin as a negative regulator of cell proliferation under DNA damage
Lab Invest,80(6):797-804 2000
Author:Ikeo, Y; Sakurai, A; Suzuki, R; Zhang, MX; Koizumi, S; Takeuchi, Y; Yumita, W; Nakayama, J; Hashizume, K


Primary cardiac malignant fibrous histiocytoma in the right ventricular infundibulum treated with a cavo-pulmonary shunt and coronary embolization
Jpn Circ J,64(12):982-984 2000
Author:Owa, M; Higashikata, T; Shimada, H; Kitahara, H; Asano, M; Nakayama, J; Hikita, H; Koyama, J; Sakurai, S; Ikeda, S


Expression of polysialic acid and STX, a human polysialyltransferase, is correlated with tumor progression in non small cell lung cancer
Cancer Res,60(11):3072-3080 2000
Author:Tanaka, F; Otake, Y;Nakagawa, T; Kawano, Y; Miyahara, R; Li, M; Yanagihara, K; Nakayama, J; Fujimoto, I; Ikenaka, K; Wada, H


Recent progress in paradoxical concanavalin A staining
Acta Histochem Cytochem,33(3):153-157 2000
Author:Nakayama, J; Katsuyama, T; Fukuda, M


Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene
Nat Genet,26(2):237-241 2000
Author:Akama T O, Nishida K, Nakayama J, Watanabe H, Ozaki K, Nakamura T, Dota A, Kawasaki S, Inoue Y, Maeda N, Yamamoto S, Fujiwara T, Thonar E J-M A, Shimomura Y, Kinoshita S, Tanigami A, Fukuda M N


Expression cloning of a human alpha1,4-N-acetylglucosaminyltransferase that forms GlcNAc alpha1-4Galbeta-R, a glycan specifically expressed in the gastric gland mucous cell-type mucin
Proc Natl Acad Sci USA,96(16):8991-8996 1999
Author:Nakayama J, Yeh J-C, Misra A K, Ito S, Katsuyama T, Fukuda M


Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta
Biol Reprod,60(3):621-627 1999
Author:Suzuki, N; Nakayama, J; Shih, IM; Aoki, D; Nozawa, S; Fukuda, MN


Detection of GB virus-C hepatitis G virus genome in peripheral blood mononuclear cells and liver tissue
J Med Virol,57(2):114-121 1999
Author:Kobayashi, M; Tanaka, E; Nakayama, J; Furuwatari, C; Katsuyama, T; Kawasaki, S; Kiyosawa, K


Brunner's gland metaplasia of residual jejunum developed long after wide resection of the small intestine
Pathol Int,49(10):918-920 1999
Author:Nakamura, T; Shimada, M; Nakayama, J; Katsuyama, T


Expression of N-acetyllactosamine and beta 1,4-galactosyltransferase (beta 4GalT-I) during adenoma-carcinoma sequence in the human colorectum
J Histochem Cytochem,47(12):1593-1601 1999
Author:Ichikawa, T; Nakayama, J; Sakura, N; Hashimoto, T; Fukuda, M; Fukuda,MN; Taki, T


The identification of specific high density lipoprotein(3) binding sites on human blood monocytes using fluorescence-labeled ligand
J Lipid Res,40(6):1131-1139 1999
Author:Hidaka, H; Hidaka, E; Tozuka, M; Nakayama, J; Katsuyama, T; Fidge, N


A novel, high endothelial venule-specific sulfotransferase expresses 6-sulfo sialyl Lewis x, an L-selectin ligand displayed by CD34
Immunity,11(1):79-89 1999
Author:Hiraoka N, Petryniak B, Nakayama J, Tsuboi S, Suzuki M, Yeh J-C, Izawa D, Tanaka T, Miyasaka M, Lowe J B, Fukuda M


Helicobacter pylori infection produces reversible glycosylation changes to gastric mucins
Virchows Archiv,433(5):419-426 1998
Author:Ota, H; Nakayama, J; Momose, M; Hayama, M; Akamatsu, T; Katsuyama, T; Graham, DY;Genta, RM


New monoclonal antibodies against gastric gland mucous cell-type mucins: a comparative immunohistochemical study
Histochem Cell Biol,110(2):113-119 1998
Author:Ota, H; Nakayama, J; Momose, M; Kurihara, M; Ishihara, K; Hotta, K; Katsuyama, T


Polysialic acid, a unique glycan that is developmentally regulated by two polysialyltransferases, PST and STX, in the central nervous system: From biosynthesis to function
Pathol Int,48(9):665-677 1998
Author:Nakayama, J; Angata, K; Ong, E; Katsuyama, T; Fukuda, M


Developmental regulation of polysialic acid synthesis in mouse directed by two polysialyltransferases,PST and STX
Glycobiology,8(4):415-424 1998
Author:Ong, E; Nakayama, J; Angata, K; Reyes, L; Katsuyama, T; Arai, Y; Fukuda, M


Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule - Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST
J Biol Chem,272(11):7182-7190 1997
Author:Angata, K; Nakayama, J; Fredette, B; Chong, K; Ranscht, B; Fukuda, M


Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O-acetylated ganglioside: A putative acetyl-CoA transporter
Proc Natl Acad Sci USA,94:2897-2902 1997
Author:Kanamori A, Nakayama J, Fukuda MN, Stallcup W B, Sasaki K, Fukuda M, Hirabayashi Y


Carcinoma-associated expression of core 2 beta-1,6-N-acetylglucosaminyltransferase gene in human colorectal cancer: Role of O-glycans in tumor progression
Cancer Res,57(23):5201-5206 1997
Author:Shimodaira, K; Nakayama, J; Nakamura, N; Hasebe, O; Katsuyama, T; Fukuda, M


Enhanced expression of prostate-specific membrane antigen gene in prostate cancer as revealed by in situ hybridization
Cancer Res,57(12):2321-2324 1997
Author:Kawakami, M; Nakayama, J


Histone H3 messenger RNA in situhybridization for identifying proliferating cells in formalin-fixed rat gastric mucosa
Histochem J,29(11-12):867-873 1997
Author:Maeyama, H; Furuwatari, C; Ota, H; Akamatsu, T; Nakayama, J; Katsuyama, T


Expression cloning of a human GT3 synthase. GD3 and GT3 are synthesized by a single enzyme
J Biol Chem,271:3684-3691 1996
Author:Nakayama J, Fukuda MN, Hirabayashi Y, Kanamori A, Sasaki K, Nishi T, Fukuda M


A human polysialyltransferase directs in vitro synthesis of polysialic acid
J Biol Chem,271:1829-1832 1996
Author:Nakayama J, Fukuda M


Expression cloning of glycosyltransferases
Glycobiology,6:683-689 1996
Author:Fukuda M, Bierhuizen MFA, Nakayama J


Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain
Proc Natl Acad Sci USA,92:7031-7035 1995
Author:Nakayama J, Fukuda MN, Fredette B, Ranscht B, Fukuda M


Application of mucin histochemistry for pathological diagnosis. - Expession of gastric phenoypes in metaplastic and neoplastic lesions and its relation to the organoid differentiation -
Acta Histochem Cytochem,28(1):43-53 1995
Author:Ota H, Katsuyama T, Akamatsu T, Fujimori Y, Matsuzawa K, Ishii K, Honda T, Nakayama J, Furihata K, Ono K, Maeda K


Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation
Genes Dev,9:1199-1210 1995
Author:Fukuda MN, Sato T, Nakayama J, Klier G, Mikami M, Aoki D, Nozawa S


Frequently relapsing minimal change nephrotic syndrome with natural killer cell deficiency prior to the overt relapse of Hodgkin’s disease
Pediatr Nephorol,9(5):619-620 1995
Author:Mori T, Yabuhara A, Nakayama J, Kitahara M, Washizawa K, Kasai S, Komiyama A


Monoclonal antibody E6G6 recognizes glycolipids as a differentiation antigen in shope carcinoma cells
Cancer Lett,81(2):221-228 1994
Author:Kyogashima M, Inoue M, Isono T, Nakayama J, Seto A


Expression of Forssman antigen in human large intestine
J Histochem Cytochem,42(5):659-665 1994
Author:Ono K, Hattori H, Uemura K, Nakayama J, Ota H, Katsuyama T


Proposal for an aeroschema (modified Aerokey II) for the identification of cllinical Aeromonas species
Med Sci Res,22(9):617-619 1994
Author:Furuwatari C, Kawakami Y, Akahane T, Hidaka E, Okimura Y, Nakayama J, Furihata K, Katsuyama T


Liver injury following normothermic ishemia in steatotic rat liver
Hepatology,20(5):1287-1293 1994
Author:Hui A, Kawasaki S, Makuuchi M, Nakayama J, Ikegami T, Miyagawa S


Establishment of Epstein-Barr virus-associated lymphoma cell line SUBL with t(2;3)(p11;q27) from a liver transplant patient
Cancer Genet Cytogenet,71(2):155-163 1993
Author:Yoshizawa K, Kiyosawa K, Yamada S, Furuta K, Yabu K, Kitano K, Akamatsu T, Nakayama J, Katsuyama T, Matsunami H, Kawasaki S, Makuuchi M, Nanba K, Furuta S


Polysialosyl glycoconjugates defined by monoclonal antibody M6704 are expressed in human gliomas and embryonic neurons
J Histochem Cytochem,41(10):1563-1572 1993
Author:Nakayama J, Katsuyama T, Sugiyama E, Hirabayashi Y


Primary hyperparathyroidism masquerading as immobilization hypercalcemia -report of an illustrative case
Endocrine J,40(1):35-39 1993
Author:Monno S, Yokozawa T, Mizushima Y, Nakayama J,Ohgaku S, Kato H, Takasu N, Kobayashi M


Organizing differentiation of tumorcells of villous adenomas of the large intestine
Acta Histochem Cytochem,26(2):117-125 1993
Author:Ota H, Nakayama J, Fujimori Y, Furihata K, Katsuyama T, Moriyama S, Hata S, Ono K


Immunohistochemical demonstration of glycoconjugates bearing the type 2 chain-backbone structurein human fetal, normal and neoplastic gastrointestinal tract
Histochemistry,97(4):303-310 1992
Author:Nakayama J, Ota H, Katsuyama T, Kanai M, Taki T, Hirabayashi Y, Suzuki Y


Aberrant expression of blood group H-antigen in shope carcinoma cells
Cancer Lett,66(3):175-181 1992
Author:Kyogashima M, Inoue M, Nakayama J, Seto A


Distribution of retinol-binding protein in the human digestive tract
Virchows Arch B,61(5):315-322 1992
Author:Kameko M, Ota H, Ishii K, Nakayama J, Katsuyama T, Kanai M, Tsutsumi Y


Histochemical demonstration of gastrointestinal mucins in ovarian mucinous cystadenoma
Acta Pathol Jpn,42(2):104-110 1992
Author:Shiozawa T, Tsukahara Y, Ishii K, Ota H, Nakayama J, Katsuyama T


The antitumor activity and immunosuppressive effects of 5-fluorouracil suppositories in rectal cancer patients
Surg Today,22(3):221-225 1992
Author:Adachi W, Sugenoya A, Horigome N, Takahashi C, Iida F, Nakayama J


Adenocarcinoma of the cervical oesophagus arising from ectopic gastric mucosa - the histochemical determination of its origin
Virchows Arch A,419(2):159-164 1991
Author:Ishii K, Ota H, Nakayama J, Katsuyama T, Matsuzawa K, Honda T, Akamtsu T


A new monoclonal antibody directed to sialyl-alpha2-3 lactoneotetraosylceramide and its application for detection of human gastrointestinal neoplasms
J Biochem (Tokyo),109(2):354-360 1991
Author:Suzuki Y, Nishi H, Hidari K, Hirabayashi Y, Matsumoto M, Kobayashi T, Watari S, Yasuda T, Nakayama J, Maeda H, Katsuyama T, Kanai M, Kiso M, Hasegawa A


Immunohistochemical reactivity of antikeratan sulfate monoclonal antibody 5D4 to various conditions of human endometrial tissues and its application as a useful marker for identifying endometrial epithelia
Gynecol Obstet Invest,32(4):239-242 1991
Author:Shiozawa T, Tsukahara Y, Nakayama J, Ishii K, Katsuyama T


Immunohistochemical localization of blood group substances in normal and neoplastic endometrial tissues - with special reference to type 1 core chain expression
Gynecol Obstet Invest,32(3):185-188 1991
Author:Shiozawa T, Tsukahara Y, Nakayama J, Ishii K, Katsuyama T


Lectin histochemistry of the normal human endometrium and endometrial adenocarcinoma
Acta Histochem Cytochem,24(2):233-240 1991
Author:Shiozawa T, Tsukahara Y, Nakayama J, Katsuyama T


A dual staining method for identifying mucins of different gastric epithelial mucous cells
Histochem J,23(1):22-28 1991
Author:Ota H, Katsuyama T, Ishii K, Nakayama J, Shiozawa T, Tsukahara Y


Griffonia simplicifolia agglutinin-2-binding glycoprotein as a novel carbohydrate antigen of human colonic carcinoma
Jpn J Cancer Res,81(4):388-395 1990
Author:Nakayama J, Okano A, Maeda H, Miyachi M, Ota H, Katsuyama T, Kanai M


Accumulation of gangliosides with N-acetylneuraminosyl(α2-6)lactosamine structure in primary human hepatoma
Cancer Res,50(4):1284-1290 1990
Author:Taki T, Yamamoto K, Takamatsu M, Ishii K, Myoga A, Sekiguchi K, Ikeda I, Kurata K, Nakayama J, Handa S, Matsumoto M


講演・口頭発表等
Preventive role of the gland mucin-specific αGlcNAc in gastric cancer development
The 12th China-Japan Joint Seminar on Histochemictry and Cytochemistry 2017
Presenter:Nakayama J


胃粘膜における腺粘液糖鎖の機能
第54回日本組織細胞化学会総会 2013
Presenter:中山 淳


糖鎖遺伝子:クローニングから機能解析,そして病理学へ-α1,4-N-アセチルグルコサミン転移酵素を中心に-
第102回日本病理学会総会 2013
Presenter:中山 淳


Preventive roles of gastric gland mucin in pathogenesis of gastric cancer
The 43rd International Symposium of The Princess Takamatsu Cancer Research Fund 2012
Presenter:Nakayama J


Dual roles of gastric gland mucin-specific O-glycan on prevention of gastric cancer
14th International Congress of Histochemistry and Cytochemistry. 2012
Presenter:Nakayama J


Interaction of Helicobacter pylori and O-glycans in stomach
Glycobiology Japan-Netherland Joint Seminar 2011 2011
Presenter:Nakayama J


A subtype of human gastric mucins expressing alpha1,4-GlcNAc-capped O-glycans functions as a natural antibiotic against Helicobacter pylori infection
US/Japan Glyco 2004 2004
Presenter:Nakayama J, Kawakubo M, Ito Y, Kobayashi M, Fukuda NM, Fukuda M, Katsuyama T


Detection of circulating gastric cancer cells using real-time RT-PCR targeted α1,4-N-Acetylglucosaminyltransferase messenger RNA
The 18th International Congress of Clinical Chemistry and Laboratory Medicine 2002
Presenter:Nakayama J, Shimizu F, Zhang MX, Fukuda M, Katsuyama T


α1,4-N-Acetylglucosaminyltransferase and gastric cancer
The 32nd International Symposium of the Princess Takamatsu Cancer Research Fund 2001
Presenter:Nakayama J, Shimizu F, Zhang MX, Fukuda M, Katsuyama T


糖転移酵素の発現クローニングとその機能解析: ポリシアル酸転移酵素とα1,4-N-アセチルグルコサミン転移酵素を中心に
第46回日本臨床病理学会総会 1999
Presenter:中山 淳


Expression cloning of a human α-1,4-N-acetylglucosaminyltransferase that forms GlcNAcα1-4Galβ-R, a unique glycan for the gastric gland mucous cell-type mucin
XVth International Symposium on Glycoconjugates 1999
Presenter:Nakayama J, Yeh JC, Misra A, Ito S, Katsuyama T, Fukuda M


神経細胞の発生・分化に重要な糖転移酵素,ポリシアル酸転移酵素の発現クローニングとその神経系における役割
第43回日本病理学会秋期特別総会 1997
Presenter:中山 淳


Developmentally regulated-expression of polysialic acid in nervous system directed by two polysialyltransferases, PST and STX
10th International Congress of Histochemistry and Cytochemistry 1996
Presenter:Nakayama J, Angata K, Ong E, Onishi N, Katsuyama T, Arai Y, Fukuda M


A newly cloned polysialyltransferase forms the embryonic form of N-CAM that facilitates neurite outgrowth
XIIIth International Symposium on Glycoconjugates 1995
Presenter:Nakayama J, Fukuda MN, Fredette B, Ranscht B, Fukuda M


MISC
Limitation in defining ablation line by maginified endoscopic imaging for endoscopic submucosal resection of gastric adenocarcinoma of fundic gland type as revealed by 3D redonstruction images of gastric tissue specimens.
J Can Assoc Gastroenterol,1:137 2018
Author:Yamada S, Matsuura H, Nakayama J


Shinshu Brain Resource Net
Neuropathology ,36:600 2016
Author:Oyanagi K, Yamada M, Hineno A, Yahikozawa H, Ushiyama M, Miki J, Kanno H, Nakayama J, Makishita H, Inoue K, Ohara S, Hayashida K, Kayanuma K, Yamamoto K, Yasude T, Hashimoto T, Yoshida K, Ikeda S-i


Interleukin-1β suppression in Blau syndrome: comment on the article by Martin et al.
Arthritis Rheum,60:2544 2009
Author:Masumoto J, Yamazaki T, Ohta K, Nakayama J, Agematsu K


Sulfation patterns of keratan sulphate in different macular corneal dystrophy immunophenotypes using three different probes
Br J Ophthalmol,92:1434 2008
Author:Saito T, Nishida K, Nakayama J, Akama TO, Fukuda MN, Watanabe K, Quantock AJ, Maeda N, Watanabe H, Tano Y


Malignant granular cell tumor of the esophagus
Virchows Arch,444:304 2004
Author:Yoshizawa A, Ota H, Sakaguchi N, Kanai S, Nakayama J, Matsuzawa K, Tsuzuki S, Takada R, Miyazawa F, Kasahara H, Katsuyama T


Relation of H pylori to gastric mucins andgastric surface mucous gel layer
Gut,48:869 2001
Author:Ota, H; Nakayama, J; Shimizu, T; Nakayama, J; Graham, DY; Katsuyama, T


Association of smoking with apoptosis-regulated proteins (Bcl-2, Bax and p53) in resected non-small-cell lung cancers
Int J Cancer,91:267 2001
Author:Hanaoka, T; Nakayama, J; Mukai, J; Irie, S; Yamanda, T; Sato, TA


Gastric gland mucous cells circulate in peripheral blood after endoscopic biopsy of the gastric mucosa
Am J Gastroenterol,10:3017 2000
Author:Shimizu, F; Nakayama, J; Sugiyama, A; Kawasaki, S; Katsuyama, T

研究費
科学研究費補助金(研究代表者)
2019 - 2021 , αGlcNAcによる胃分化型癌の制御機構 , 基盤研究(B)
2016 - 2018 , プロテオミクスを用いた腺粘液糖鎖による胃癌発生制御機構の解明 , 挑戦的萌芽研究
2015 - 2017 , スルホムチンを介する新規胃癌発生メカニズムの解明 , 基盤研究(B)
2013 - 2015 , 胃癌発生におけるIL-33の役割 -新規モデルマウスを用いた解析- , 挑戦的萌芽研究
2012 - 2014 , 粘液糖鎖による胃癌発生の制御 , 基盤研究(B)
2009 - 2011 , 胃腺粘液糖鎖合成酵素の遺伝子多型と、その胃疾患発症因子としての意義 , 基盤研究(B)
2006 - 2008 , 神経膠腫で発現するコンドロイチン硫酸Eの機能解析 , 基盤研究(B)
2003 - 2005 , 大腸癌で発現する着床関連接着分子,トロフィニンの機能解析 , 基盤研究(B)
2002 - 2006 , O-グリカンによるH. ピロリ感染の制御 , 特定領域研究
2002 - 2002 , 糖転移酵素,α4GnT遺伝子をターゲットとした膵・胆道癌の分子診断法の開発 , 特定領域研究
2000 - 2001 , 移植肝における急性拒絶反応の発生機序に関する分子病理学的研究 , 基盤研究(C)
2000 - 2000 , 胃癌・膵癌で発現するGlcNAcα1→4Galβ残基を有する粘液の機能解析 , 特定領域研究(A)
1999 - 1999 , 発現クローニングで単離したα1,4-N-アセチルグルコサミン転移酵素の機能解析 , 特定領域研究(A)
1998 - 1998 , 神経芽細胞腫で発現するポリシアル酸の機能解析 , 特定領域研究(A)
1997 - 1999 , 大腸癌の悪性度に関与する糖転移酵素の分子病理学的研究 , 基盤研究(C)
研究諸活動
学術専門雑誌等編集
J Histochem Cytochem
Acta Histochem Cytochem
Histochem Cell Biol

教育活動実績

授業等
2022 , 前期 , 病理学総論演習・実習 (病理学総論)
2022 , 前期 , 形態学研究方法特論
2022 , 前期 , 人間疾病・治療学概論II
2022 , 前期 , 新入生ゼミナール
2022 , 前期 , 共通教育講義(ノーベル賞から探るからだのしくみ)
2022 , 後期 , 病理学演習・実習 (病理学各論) II

社会活動実績

社会活動等
講演会
2015 - , 第18回信州消化器H.pylori研究講演会 , 当番幹事
2008 - , 第11回信州消化器H.pylori研究講演会 , 当番幹事

学会・研究会の主催等
2014 - , 第55回日本組織細胞化学会総会・学術集会 , 会長
2011 - , 第8回日本病理学会カンファレンス 2011 松本 , 世話人
2011 - , 第37 回上信越神経病理懇談会(日本神経病理学会上信越地方会) , 世話人代表

学外審議会・委員会
2020 - 2021 , (独)大学評価・学位授与機構 国立大学教育研究評価委員会 , 専門委員
2017 - 2018 , (独)日本学術振興会 科学研究費委員会 , 専門委員
2016 - 2017 , (独)大学評価・学位授与機構 国立大学教育研究評価委員会 , 専門委員
2015 - 2016 , (独)日本学術振興会 科学研究費委員会 , 専門委員
2014 - 2015 , (独)日本学術振興会 科学研究費委員会 , 専門委員
2009 - 2010 , (独)日本学術振興会 科学研究費委員会 , 専門委員
2008 - 2008 , (独)日本学術振興会 科学研究費委員会 , 専門委員
2006 - 2007 , (独)新エネルギー・産業技術総合開発機構 , NEDO技術委員
2004 - 2006 , (独)日本学術振興会 特別研究員等審査会 , 専門委員