Shinshu University Researcher Directory｜Shinshu University Online system of General Academic Resources SOAR

Academic Organization	Academic Assembly　School of Medicine and Health Sciences　Institute of Health Science	TEL
Education and Research Organization	School of Medicine　Department of Biomedical Laboratory Sciences	FAX
Position	Professor	Mail Address
Address	3-1-1, Asahi, Matsumoto, Nagano, JAPAN	Web site

Profile

Research Field: Hematology

Current Subject: molecular pathogenesis of bone marrow failure including pure red cell aplasia
Keywords:bone marrow failure , pure red cellaplasia , T cell

Academic Societies: Academic Societies
Japanese Society of Hematology

Academic Background: Graduate School
Shinshu University , (Graduate School, Division of Medicine) , 1994

College
Shinshu University , (Faculty of Medicine) , 1985

Degree
Doctor of Medicine

Research

Books, Articles, etc.: Books
血小板膜糖蛋白
文光堂，東京 , Medical Practice編集委員会編：臨床検査ガイド2005～2006 , :pp 590-592 2005
Author:牧島秀樹，石田文宏

Articles
STAT3 mutations in natural killer cells are associated with cytopenia in patients with chronic lymphoproliferative disorder of natural killer cells
INTERNATIONAL JOURNAL OF HEMATOLOGY,109(5):563-571 2019(May)
Author:Kawakami, Toru; Sekiguchi, Nodoka; Kobayashi, Jun; Yamane, Taku; Nishina, Sayaka; Sakai, Hitoshi; Hirabayashi, Yukio; Nakazawa, Hideyuki; Ishida, Fumihiro;

Phase II study of FLAGM (fludarabine plus high-dose cytarabine plus granulocyte colony-stimulating factor plus mitoxantrone) for relapsed or refractory acute myeloid leukemia
INTERNATIONAL JOURNAL OF HEMATOLOGY,109(4):418-425 2019(Apr.)
Author:Hatsumi, Nahoko; Miyawaki, Shuichi; Yamauchi, Takahiro; Takeshita, Akihiro; Komatsu, Norio; Usui, Noriko; Arai, Yukihiro; Ishida, Fumihiro; Morii, Takeshi; Kano, Yasuhiko; Ogura, Michinori; Machida, Shinichiro; Nishii, Kazuhiro; Honda, Sumihisa; Ohnishi, Kazunori; Naoe, Tomoki; JALSG;

Tumor long-axis diameter and SUVmax predict long-term responders in 90Y-ibritumomab tiuxetan monotherapy
INTERNATIONAL JOURNAL OF HEMATOLOGY,109(1):91-97 2019(Jan.)
Author:Tsukamoto, Norifumi; Yokohama, Akihiko; Higuchi, Tetsuya; Mitsui, Takeki; Koiso, Hiromi; Takizawa, Makiko; Shimizu, Hiroaki; Ishizaki, Takuma; Matsumoto, Morio; Toyama, Kohtaro; Sakura, Tohru; Ogura, Hidemi; Saitoh, Takayuki; Ishida, Fumihiro; Murakami, Hirokazu; Tsushima, Yoshito; Handa, Hiroshi;

Efficacy and safety of obinutuzumab in patients with previously untreated follicular lymphoma: a subgroup analysis of patients enrolled in Japan in the randomized phase III GALLIUM trial
INTERNATIONAL JOURNAL OF HEMATOLOGY,108(5):499-509 2018(Nov.)
Author:Ohmachi, Ken; Tobinai, Kensei; Kinoshita, Tomohiro; Ishikawa, Takayuki; Hatake, Kiyohiko; Ichikawa, Satoshi; Ohmine, Ken; Kamitsuji, Yuri; Choi, Ilseung; Chou, Takaaki; Tsukasaki, Kunihiro; Kumagai, Kyoya; Taniwaki, Masafumi; Uchida, Toshiki; Kikukawa, Yoshitaka; Kubo, Kohmei; Mihara, Keichiro; Tsukamoto, Norifumi; Izutsu, Koji; Yoshida, Isao; Ishida, Fumihiro; Usui, Noriko; Iida, Shinsuke; Murayama, Tohru; Ueda, Eisuke; Kuriki, Hiroshi; Ando, Kiyoshi;

Aggressive NK-Cell Leukemia
FRONTIERS IN PEDIATRICS,6:1-5 2018(Oct.)
Author:Ishida, Fumihiro;

Frequent STAT3 mutations in CD8+ T cells from patients with pure red cell aplasia
BLOOD ADVANCES,2:2704-2712 2018(Oct.)
Author:Toru Kawakami, Nodoka Sekiguchi, Jun Kobayashi, Tatsuya Imi, Kazuyuki Matsuda, Taku Yamane, Sayaka Nishina, Yasushi Senoo, Hitoshi Sakai, Toshiro Ito, Tomonobu Koizumi, Makoto Hirokawa, Shinji Nakao, Hideyuki Nakazawa, Fumihiro Ishida

Prognostic Analysis According to the 2017 ELN Risk Stratification by Genetics in Adult Acute Myeloid Leukemia Patients Treated in The Japan Adult Leukemia Study Group (JALSG) AML201 study
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA,18:S196-S196 2018(Sep.)
Author:Harada, Yasuhiko; Nagata, Yasunobu; Kihara, Rika; Ishikawa, Yuichi; Asou, Norio; Ohtake, Shigeki; Miyawaki, Shuichi; Sakura, Toru; Ozawa, Yukiyasu; Usui, Noriko; Kanamori, Heiwa; Ito, Yoshikazu; Imai, Kiyotoshi; Suehiro, Youko; Kobayashi, Shinichi; Kitamura, Kunio; Sakaida, Emiko; Onizuka, Makoto; Takeshita, Akihiro; Ishida, Fumihiro; Suzushima, Hitoshi; Ishizawa, Kenichi; Naoe, Tomoki; Matsumura, Itaru; Miyazaki, Yasushi; Ogawa, Seishi; Kiyoi, Hitoshi;

Breakthrough Candida guilliermondii (Meyerozyma guilliermondii) fungemia after cord blood transplantation for extranodal NK-cell lymphoma with azole prophylaxis
TRANSPLANT INFECTIOUS DISEASE,20(4):- 2018(Aug.)
Author:Nakazawa, Hideyuki; Nishina, Sayaka; Senoo, Yasushi; Sakai, Hitoshi; Ito, Toshiro; Kikuchi, Ken; Ishida, Fumihiro;

Breakthrough Candida guilliermondii (Meyerozyma guilliermondii) fungemia after cord blood transplantation for extranodal NK-cell lymphoma with azole prophylaxis
TRANSPLANT INFECTIOUS DISEASE,20(4):- 2018(Aug.)
Author:Nakazawa, Hideyuki; Nishina, Sayaka; Senoo, Yasushi; Sakai, Hitoshi; Ito, Toshiro; Kikuchi, Ken; Ishida, Fumihiro;

Bortezomib maintenance therapy in transplant-ineligible myeloma patients who plateaued after bortezomib-based induction therapy: a multicenter phase II clinical trial
INTERNATIONAL JOURNAL OF HEMATOLOGY,108(1):39-46 2018(Jul.)
Author:Isoda, Atsushi; Murayama, Kayoko; Ito, Shigeki; Kohara, Yoichi; Iino, Masaki; Miyazawa, Yuri; Matsumoto, Morio; Handa, Hiroshi; Imai, Yosuke; Ishiguro, Takuro; Izumita, Wataru; Kitano, Kiyoshi; Hirabayashi, Yukio; Nakazawa, Hideyuki; Ishida, Fumihiro; Mitsumori, Toru; Kirito, Keita; Chou, Takaaki; Murakami, Hirokazu; Kanshinetsu Multiple Myeloma Study;

Bortezomib maintenance therapy in transplant-ineligible myeloma patients who plateaued after bortezomib-based induction therapy: a multicenter phase II clinical trial
INTERNATIONAL JOURNAL OF HEMATOLOGY,108(1):39-46 2018(Jul.)
Author:Isoda, Atsushi; Murayama, Kayoko; Ito, Shigeki; Kohara, Yoichi; Iino, Masaki; Miyazawa, Yuri; Matsumoto, Morio; Handa, Hiroshi; Imai, Yosuke; Ishiguro, Takuro; Izumita, Wataru; Kitano, Kiyoshi; Hirabayashi, Yukio; Nakazawa, Hideyuki; Ishida, Fumihiro; Mitsumori, Toru; Kirito, Keita; Chou, Takaaki; Murakami, Hirokazu; Kanshinetsu Multiple Myeloma Study;

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target
NATURE COMMUNICATIONS,9:1-12 2018(Apr.)
Author:Dufva, Olli; Kankainen, Matti; Kelkka, Tiina; Sekiguchi, Nodoka; Awad, Shady Adnan; Eldfors, Samuli; Yadav, Bhagwan; Kuusanmaki, Heikki; Malani, Disha; Andersson, Emma I.; Pietarinen, Paavo; Saikko, Leena; Kovanen, Panu E.; Ojala, Teija; Lee, Dean A.; Loughran, Thomas P., Jr.; Nakazawa, Hideyuki; Suzumiya, Junji; Suzuki, Ritsuro; Ko, Young Hyeh; Kim, Won Seog; Chuang, Shih-Sung; Aittokallio, Tero; Chan, Wing C.; Ohshima, Koichi; Ishida, Fumihiro; Mustjoki, Satu;

Prognostic analysis according to the 2017 ELN risk stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 study
LEUKEMIA RESEARCH,66:20-27 2018(Mar.)
Author:Harada, Yasuhiko; Nagata, Yasunobu; Kihara, Rika; Ishikawa, Yuichi; Asou, Norio; Ohtake, Shigeki; Miyawaki, Shuichi; Sakura, Toru; Ozawa, Yukiyasu; Usui, Noriko; Kanamori, Heiwa; Ito, Yoshikazu; Imai, Kiyotoshi; Suehiro, Youko; Kobayashi, Shinichi; Kitamura, Kunio; Sakaida, Emiko; Onizuka, Makoto; Takeshita, Akihiro; Ishida, Fumihiro; Suzushima, Hitoshi; Ishizawa, Kenichi; Naoe, Tomoki; Matsumura, Itaru; Miyazaki, Yasushi; Ogawa, Seishi; Kiyoi, Hitoshi; Japan Adult Leukemia Study Grp;

Severe Infection of Pseudomonas aeruginosa during Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria
INTERNAL MEDICINE,57(1):127-130 2018
Author:Kawakami, Toru; Nakazawa, Hideyuki; Kurasawa, Yukifumi; Sakai, Hitoshi; Nishina, Sayaka; Senoo, Noriko; Senoo, Yasushi; Ishida, Fumihiro;

大顆粒リンパ球増多症 (特集リンパ球の増減を正しく評価するために)
臨床検査 = Journal of clinical laboratory medicine,61(8):976-982 2017(Aug.)
Author:石田文宏;
Keywords:大顆粒リンパ球(LGL)白血病; 細胞傷害性T細胞; NK細胞; STAT;

Oral cyclophosphamide was effective for Coombs-negative autoimmune hemolytic anemia in CD16+CD56-chronic lymphoproliferative disorder of NK-cells
INTERNATIONAL JOURNAL OF HEMATOLOGY,105(6):854-858 2017(Jun.)
Author:Sekiguchi, Nodoka; Nishina, Sayaka; Kawakami, Toru; Sakai, Hitoshi; Senoo, Noriko; Senoo, Yasushi; Ito, Toshiro; Saito, Hiroshi; Nakazawa, Hideyuki; Koizumi, Tomonobu; Ishida, Fumihiro;

A screening method with lymphocyte percentage and proportion of granular lymphocytes in the peripheral blood for large granular lymphocyte (LGL) leukemia
INTERNATIONAL JOURNAL OF HEMATOLOGY,105(1):87-91 2017(Jan.)
Author:Tanahashi, Takahiro; Sekiguchi, Nodoka; Matsuda, Kazuyuki; Matsumoto, Akihiro; Ito, Toshiro; Nakazawa, Hideyuki; Ishida, Fumihiro;

Cell size variations of large granular lymphocyte leukemia: Implication of a small cell subtype of granular lymphocyte leukemia with STAT3 mutations
LEUKEMIA RESEARCH,45:8-13 2016(Jun.)
Author:Tanahashi, Takahiro; Sekiguchi, Nodoka; Matsuda, Kazuyuki; Takezawa, Yuka; Ito, Toshiro; Kobayashi, Hikaru; Ichikawa, Naoaki; Nishina, Sayaka; Senoo, Noriko; Sakai, Hitoshi; Nakazawa, Hideyuki; Ishida, Fumihiro;

A prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment: a multicentre, retrospective analysis
LANCET ONCOLOGY,17(3):389-400 2016(Mar.)
Author:Kim, Seok Jin; Yoon, Dok Hyun; Jaccard, Arnaud; Chng, Wee Joo; Lim, Soon Thye; Hong, Huangming; Park, Yong; Chang, Kian Meng; Maeda, Yoshinobu; Ishida, Fumihiro; Shin, Dong-Yeop; Kim, Jin Seok; Jeong, Seong Hyun; Yang, Deok-Hwan; Jo, Jae-Cheol; Lee, Gyeong-Won; Choi, Chul Won; Lee, Won-Sik; Chen, Tsai-Yun; Kim, Kiyeun; Jung, Sin-Ho; Murayama, Tohru; Oki, Yasuhiro; Advani, Ranjana; d'Amore, Francesco; Schmitz, Norbert; Suh, Cheolwon; Suzuki, Ritsuro; Kwong, Yok Lam; Lin, Tong-Yu; Kim, Won Seog;

Exogenous Magnesium Chloride Reduces the Activated Partial Thromboplastin Times of Lupus Anticoagulant-Positive Patients
PLOS ONE,11(6):- 2016
Author:Tokutake, Takayoshi; Baba, Hisami; Shimada, Yuji; Takeda, Wataru; Sato, Keijiro; Hiroshima, Yuki; Kirihara, Takehiko; Shimizu, Ikuo; Nakazawa, Hideyuki; Kobayashi, Hikaru; Ishida, Fumihiro;

High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia
BLOOD,128(20):2465-2468 2016
Author:Andersson, Emma I.; Tanahashi, Takahiro; Sekiguchi, Nodoka; Gasparini, Vanessa Rebecca; Bortoluzzi, Sabrina; Kawakami, Toru; Matsuda, Kazuyuki; Mitsui, Takeki; Eldfors, Samuli; Bortoluzzi, Stefania; Coppe, Alessandro; Binatti, Andrea; Lagstrom, Sonja; Ellonen, Pekka; Fukushima, Noriyasu; Nishina, Sayaka; Senoo, Noriko; Sakai, Hitoshi; Nakazawa, Hideyuki; Kwong, Yok-Lam; Loughran, Thomas P.; Maciejewski, Jaroslaw P.; Mustjoki, Satu; Ishida, Fumihiro;

NK細胞腫瘍の診断と治療における最近の進歩
臨床血液,56(6):645-650 2015
Author:石田文宏;
Abstract:アグレッシブNK細胞白血病(ANKL)は成熟NK細胞の白血病で，生存期間中央値が3か月以内と予後不良である。東アジアに多く，8割以上がEBウイルスと関連する。最近実施した34例のANKL07研究では年齢中央値40歳で2相性分布を示した。ANKLの細胞はLGL様から高度異型まで多彩であり，また，三分の一の例では末梢血・骨髄の腫瘍細胞が20%未満であり，診断に留意する必要がある。臨床所見として発熱，肝障害，血球貪食症候群と進行性の経過を認めた。一部の症例ではL-アスパラギナーゼを含む化学療法と同種造血幹細胞移植(HSCT)が有効で治癒可能性が示唆された。節外性NK/T細胞リンパ腫，鼻型(ENKL)に対するHSCTは臨床病期II期以上の症例で完全奏効時に施行された場合には生存期間の延長や治癒につながる可能性があるが，至適な幹細胞ソース，実施時期，前処置等今後更に検討する必要がある。
Keywords:Mature NK cell neoplasm; L-asparaginase; Hematopoietic stem cell transplantation; Epstein-Barr virus;

Prognostic significance of pleural or pericardial effusion and the implication of optimal treatment in primary mediastinal large B-cell lymphoma: a multicenter retrospective study in Japan
HAEMATOLOGICA,99(12):1817-1825 2014(Dec.)
Author:Aoki, Tomohiro; Izutsu, Koji; Suzuki, Ritsuro; Nakaseko, Chiaki; Arima, Hiroshi; Shimada, Kazuyuki; Tomita, Akihiro; Sasaki, Makoto; Takizawa, Jun; Mitani, Kinuko; Igarashi, Tadahiko; Maeda, Yoshinobu; Fukuhara, Noriko; Ishida, Fumihiro; Niitsu, Nozomi; Ohmachi, Ken; Takasaki, Hirotaka; Nakamura, Naoya; Kinoshita, Tomohiro; Nakamura, Shigeo; Ogura, Michinori;

STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia
CANCER SCIENCE,105(3):342-346 2014(Mar.)
Author:Ishida, F; Matsuda, K; Sekiguchi, N; Makishima, H; Taira, C; Momose, K; Nishina, S; Senoo, N; Sakai, H; Ito, T; Kwong, YL

アグレッシブNK細胞白血病の臨床病態と治療
血液内科,68(1):124-128 2014(Jan.)
Author:石田文宏;
Keywords:natural killer cell; large granular lymphocyte; Epstein-Barr virus; L-asparaginase; allogeneic hematopoietic cell transplantation;

Screening Tests Using Serum Tissue Transglutaminase IgA May Facilitate the Identification of Undiagnosed Celiac Disease among Japanese Population
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES,11(8):819-823 2014
Author:Nakazawa, Hideyuki; Makishima, Hideki; Ito, Toshiro; Ota, Hiroyoshi; Momose, Kayoko; Sekiguchi, Nodoka; Yoshizawa, Kaname; Akamatsu, Taiji; Ishida, Fumihiro;

Large vessel vasculitis developed early after allogeneic bone marrow transplant for acute erythroid leukemia
LEUKEMIA & LYMPHOMA,54(12):2748-2749 2013(Dec.)
Author:Kawakami, Toru; Ito, Toshiro; Sakai, Hitoshi; Sekiguchi, Nodoka; Nakazawa, Hideyuki; Senoo, Noriko; Nishina, Sayaka; Ishida, Fumihiro;

CD56 expression is an independent prognostic factor for relapse in acute myeloid leukemia with t(8;21)
LEUKEMIA RESEARCH,37(9):1021-1026 2013(Sep.)
Author:Iriyama, Noriyoshi; Hatta, Yoshihiro; Takeuchi, Jin; Ogawa, Yoshiaki; Ohtake, Shigeki; Sakura, Toru; Mitani, Kinuko; Ishida, Fumihiro; Takahashi, Masatomo; Maeda, Tomoya; Izumi, Tohru; Sakamaki, Hisashi; Miyawaki, Shuichi; Honda, Sumihisa; Miyazaki, Yasushi; Taki, Tomohiko; Taniwaki, Masafumi; Naoe, Tomoki;

Liver Dysfunction and Thrombocytopenia Diagnosed as Intravascular Large B-cell Lymphoma Using a Timely and Accurate Transjugular Liver Biopsy
INTERNAL MEDICINE,52(17):1903-1908 2013
Author:Sekiguchi, N; Joshita, S; Yoshida, T; Kurozumi, M; Sano, K; Nakagawa, M; Ito, T; Matsushita, T; Komatsu, D; Komatsu, M; Ito, T; Umemura, T; Ikeda, S; Kadoya, M; Ishida, F; Tanaka, E

Splicesome-related gene mutations in myelodysplastic syndrome can be used as stable markers for monitoring minimal residual disease during follow-up
Leukemia Res 2012
Author:Matsuda K, Ishida F, Ito T, Nakazawa H, Miura S, Taira C, Sueki A, Kobayashi Y, Honda T

Aggressive NK-cell leukemia: Therapeutic potentialsof L-asparaginase and allogeneic hematopoietic stem cell transplantation.
Cancer Science,103(6):1079-83 2012
Author:Ishida, F, Ko, Y H, Kim, W S, Suzumiya J, Isobe Y, Oshimi K, Nakamura S, Suzuki R

Donor lymphocyte infusion for extranodal NK/T cell lymphoma, nasal type, relapsed after allogeneic hematopoietic stem cell transplantation
Bone Marrow Transplantation.,46:1270-71 2011
Author:Ito T, Makishima H, Nakazawa H, Senoo Y, Senoo N, Ishida F.

Phase II study of SMILE chemotherapy for newly-diagnosed stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type: the NK-cell Tumor Study Group (NKTSG) study.
J Clin Oncol,29:4410-4416 2011
Author:Yamaguchi M, Kwong YL, Kim, WS, Maeda Y, Hashimoto C, Suh C, Izutu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R Nakamura S, Oshimi K, Suzuki R

Quantitative monitoring of single nucleotidemutations by allele-specific quantitative PCR can be used for the assessment of minimal residual disease in patients with hematological malignancies throughout their clinical cours
Clinica Chimica Acta,412:53-8 2011
Author:Taira C, Matsuda K, Kamijyo Y, Sakashita K, Ishida F, Kumagai T, Yamauchi K, Okumura N, Honda T

A C-terminal amino acid substitution in the gamma-chain caused by a novel heterozygous frameshift mutation (Fibrinogen Matsumoto VII) results in hypofibrinogenaemia
THROMBOSIS AND HAEMOSTASIS,104(2):213-223 2010(Aug.)
Author:Fujihara, Noriko; Haneishi, Ayumi; Yamauchi, Kazuyoshi; Terasawa, Fumiko; Ito, Toshiro; Ishida, Fumihiro; Okumura, Nobuo

Late relapse of extranodal natural killer/T cell lymphoma, nasal type, after more than ten years
LEUKEMIA&LYMPHOMA,51(1):171-173 2010(Jan.)
Author:Ishida, Fumihiro; Nishina, Sayaka; Asano, Naoko; Sasaki, Shigeru; Sekiguchi, Nodoka; Nakazawa, Hideyuki; Ito, Toshiro; Shikama, Naoto

The diagnosis and management of natural killer cell malignancies.
Expert Review of Hematology,3:593-602 2010
Author:Ishida F, Kwong YL

Spontaneous regression of the inhibitor against the coagulation factor XIII A subunit in acquired factor XIII deficiency
Thromb and Haemost,104:1284-5 2010
Author:Ishida F. Okubo K, Ito T, Okumura N, Souri M, Ichinose A

Age-ralated Epstein-Barr virus(EBV) associated B-cell lymphoproliferative disorders:comparison with EBV-positive classic Hodgkin lymphoma in elderly patients
BLOOD,113:2629-2636 2009
Author:Asano N, Yamamoto K, Tamaru J, Oyama T, Ishida F, Oshima K, Yoshino T, Nakumara N, Mori S, Yoshie O,Shimoyama Y, Morishima Y, Kinoshita T, Nakamura S

Promising approach for aggressive NK cell leukaemia with allogeneic haematopoietic cell transplantation
Eur J Haemat,81:107-111 2008
Author:Ito T, Makishima H, Nakazawa H, Kobayashi H, Shimodaira S, Nakazawa Y, Kitano K, Matsuda K, Hidaka E,　 Ishida F

Zygomycosis presenting as acute myocardial infarction during hematological malignancies
INTERNAL MEDICINE,47(9):839-842 2008
Author:Joshita, Satoru; Kitano, Kiyoshi; Nagaya, Tadanobu; Kamijo, Atsushi; Nakazawa, Koh; Ishida, Fumihiro

Chemokine system and tissue infiltration in aggressive NK-cell leukemia.
Leukemia Res,31:1245-1253 2007
Author:Makishima　H, Ito T, Momose K, Nakazawa H, Shimodaira S, Kamijo Y, Nakazawa Y, Ichikawa N, Ueno M, Kobayashi H, Kitano K, Saito H, Kiyosawa K, Ishida F.

Prognostic significance of T-cell or cytotoxic molecules phenotype in classical Hodgkin’s lymphoma: a clinicopathologic study
J Clin Oncol,24:2646-2633 2006
Author:Asano N, Oshiro A, Matsuo K, Kagami Y, Ishida F, Suzuki R, Kinoshita T, Shimoyama Y, Tamaru J, Yoshino T, Kitamura K, Fukutani H, Morishima Y, Nakamura S.

Intestinal diffuse large B cell lymphoma associated with celiac disease -a Japanesecase
Int J Hematol,83(1):63-65 2006
Author:Makishima H, Ito T, Kodama R, Asano N, Nakazawa H, Hirabayashi K, Nakamura S, Ota M, Akamatsu T, Kiyosawa K, Ishida F.

Prognostic significance of T-cell or cytotoxic molecules phenotype in classical Hodgkin's lymphoma: A clinicopathologic study
JOURNAL OF CLINICAL ONCOLOGY,24(28):4626-4633 2006
Author:Asano, N; Oshiro, A; Matsuo, K; Kagami, Y; Ishida, F; Suzuki, R; Kinoshita, T; Shimoyama, Y; Tamaru, JI; Yoshino, T; Kitamura, K; Fukutani, H; Morishima, Y; Nakamura, S

Thrombotic thrombocytopenic purpura associated with pegylated-interferon alpha-2a by an ADAMTS13 inhibitor in a patient with chronic hepatitis C
Haematologica,91:ECR34 2006
Author:Kitano K, Gibo Y, Kamijo A, Furuta K, Oguchi S, Joshita S, Takahashi Y, Ishida F, Matsumoto M, Uemura M, Fujimura Y

A case of acute myelogenous leukemia with MLL-AF10 fusion caused by insertion of 5’ MLL into 10p12, with concurrent 3’ MLL deletion
Cancer Genet Cytogenet,171(1):24-30 2006
Author:Matsuda K, Hidaka E, Ishida F, Yamauchia K, Makishima H, Ito T, Suzuki T, Imagawa E, Sano K, Katsuyama T, Ota H

Adenovirus fulminant hepatic failure after unrelated allogeneic stem cell transplantation for acute lymphoblastic leukemia
Internal Med,4:975-980 2006
Author:Nakazawa H, Ito T, Makishima H, Misawa N, Okiyama W, Uehara T, Hidaka E, Kiyosawa K, Ishida F

Significance of chemokine receptor expression in aggressive NK cell leukemia
Leukemia,19(7):1169-1174 2005
Author:Makishima H, Ito T, Asano N, Nakazawa H, Shimodaira S, Kamijo Y, Nakazawa Y, Suzuki T, Kobayashi H, Kiyosawa K, Ishida F

Clinicopathologic and prognostic significance of cytotoxic molecule expression in nodal peripheral T-cell lymphoma, unspecified
Am J Surg Pathol,29(10):1284-1293 2005
Author:Asano N, Suzuki R, Kagami Y, Ishida F, Kitamura K, Fukutani H, Morishima Y, Takeuchi K,Nakamura S

Ribavirin-induced pure red-cell aplasia during treatment of chronic hepatitis C
N Engl J Med,350(12):1264-1265 2004
Author:Tanaka .N, Ishida F, Tanaka E

DNA microarray analysis of natural kller cell-type lymphoproliferative disease of granular lymphocytes with purified CD3-CD56+ fractions
Leukemia,18(3):556-565 2004
Author:Choi YL, Makishima H, Ohashi J, Yamashita Y, Ohki R, Koinuma K, Ota J, Isobe Y, Ishida F, Oshimi K, Mano H

抗血小板自己抗体測定法 (第2世代の方法と第3世代の方法)
日本臨床,61:564-568 2003
Author:石田文宏;

Idiopathic myelofibrosis with refractory massive ascites
Intern Med,42(6):525-528 2003
Author:Yotsumoto M, Ishida F, Ito T, Ueno M, Kitano K, Kiyosawa K

Lymphoproliferative disease of granular lymphocytes with T-cell receptor gamma delta-positive phenotype: restricted usage of T-cell receptor gamma and delta subunit genes
Eur J Haematol,70(4):212-218 2003
Author:Makishima H, Ishida F, Saito H, Ichikawa N, Ozaki Y, Ito S, Ota M, Katsuyama Y, Kiyosawa K

Human factor VII deficiency caused by S339C mutation located adjacent to the specificity pocket of the catalytic domain
Clin Lab Haematol,24(4):233-238 2002
Author:Takamiya O, Seta M, Tanaka K, Ishida F

DNA microarray analysis of T cell-type lymphoproliferative disease of granular lymphocytes
Br J Haematol,118(2):462-469 2002
Author:Makishima H, Ishida F, Ito T, Kitano K, Ueno S, Ohmine K, Yamashita Y, Ota J, Ota M, Yamauchi K, Mano H

t (8;21;14) (q22;q22;q24) is a novel variant of t (8;21) with chimeric transcripts of AML1-ETO in acute myelogenous leukemia
Cancer Genet Cytogenet,132(2):133-135 2002
Author:Ishida F, Ueno M, Tanaka H, Makishima H, Suzawa K, Hosaka S, Hidaka E, Ishikawa M, YamauchiK, Kitano K, Kiyosawa K

Fibrinogen Matsumoto V: a variant with a alpha 19 Arg ->Gly (AGG ->GGG) - Comparison between fibrin polymerization stimulated by thrombin or reptilase and fibrin monomer polymerization
THROMBOSIS AND HAEMOSTASIS,85(1):108-113 2001
Author:Tanaka, H; Terasawa, F; Ito, T; Tokunaga, S; Ishida, F; Kitano, K; Kiyosawa, K; Okumura, N

Abnormal proliferation of CD4(-) CD8(+) gamma delta(+) T cells with chromosome 6 anomaly: Role of fas ligand expression in spontaneous regression of the cells
AMERICAN JOURNAL OF HEMATOLOGY,60(4):305-308 1999
Author:Ichikawa, N; Kitano, K; Ito, T; Nakazawa, T; Shimodaira, S; Ishida, F; Kiyosawa, K

Fibrinogen Matsumoto III: a variant with gamma 275 Arg ->Cys (CGC ->TGC) - Comparison of fibrin polymerization properties with those of Matsumoto I (gamma 364 Asp ->His) and Matsumoto II (gamma 308 Asn ->Lys)
THROMBOSIS AND HAEMOSTASIS,81(5):763-766 1999
Author:Terasawa, F; Okumura, N; Higuchi, Y; Ishikawa, S; Tozuka, M; Ishida, F; Kitano, K; Katsuyama, T

Hairy cell leukemia with translocation (11;20)(q13;q11) and overexpression of cyclin D1
LEUKEMIA RESEARCH,23(8):763-765 1999
Author:Ishida, F; Kitano, K; Ichikawa, N; Ito, T; Kohara, Y; Taniguchi, T; Motokura, T; Kiyosawa, K

Elliptocytosis in myelodysplastic syndrome associated with translocation (1;5)(p10;q10) and deletion of 20q
Cancer Genet Cytogenet,108(2):162-165 1999
Author:Ishida, F; Shimodaira, S; Kobayashi, H; Saito, H; Kako, M; Kanzaki, A; Yawata, Y; Kitano, K; Kiyosawa, K

フローサイトメトリーによるBtk蛋白欠損にて診断し得た伴性劣性無ガンマグロブリン血症孤発例 (本邦最高齢症例)
臨床血液,39(1):44-47 1998(Jan. 30)
Author:石田文宏; 小林光; 斉藤博; 二谷武; 宮脇利男; 清澤研道;
Abstract:症例は39歳，男性。幼児期より気道の易感染傾向があり，4歳時ポリオ生ワクチン接種後左上下肢の不全麻痺となっている。22歳時IgG, IgA, IgMの著減，抗原刺激に対する抗体反応の欠如を認めlate onset hypo-γ-globulinemiaでvariable immunodeficiencyと診断された（袖山ほか，日内会誌71: 84∼90, 1982）。その後γ-グロブリン補充療法を受けていたが数度の上気道感染，肺炎で入院している。今回再検討し末梢血中のB細胞が1%以下と減少し，フローサイトメトリーで単球上のBruton型チロシンキナーゼ欠損が証明され伴性劣性無ガンマグロブリン血症(XLA)孤発例と診断した。母親は保因者であった。本例はわれわれの知る限り，XLAの本邦最高齢である。
Keywords:X-linked agammaglobulinemia; Bruton-type tyrosine kinase; flow cytometry;

Cold agglutinin disease by autoanti-i blood type antibody associated with B cell chronic lymphocytic leukemia
INTERNATIONAL JOURNAL OF HEMATOLOGY,67(1):69-73 1998
Author:Ishida, F; Saito, H; Kitano, K; Kiyosawa, K

Associations between polymorphism of platelet membrane glycoprotein Ib alpha, plasma von Willebrand factor antigen and coronary artery disease.
BLOOD,92(10):191A-191A 1998
Author:Ito, T; Ishida, F; Shimodaira, S; Takei, M; Kitano, K; Kiyosawa, K

東アジアにおけるAPCレジスタンス測定の意義
臨床血液 = The Japanese Journal of Clinical Hematology,38(4):316-318 1997(Apr. 30)
Author:石田文宏; 高宮脩;
Keywords:APC resistance; Factor V; easten Asia;

Resistance to activated protein C and Arg 506 Gln factor V mutation are uncommon in eastern Asian populations
ACTA HAEMATOLOGICA,98(1):22-25 1997
Author:Kodaira, H; Ishida, F; Shimodaira, S; Takamiya, O; Furihata, K; Kitano, K

Eosinophilia associated with clonal T-cell proliferation
LEUKEMIA&LYMPHOMA,27(3-4):335-342 1997
Author:Kitano, K; Ichikawa, N; Shimodaira, S; Ito, T; Ishida, F; Kiyosawa, K

Elevated IgG4 levels in a case with multicentric Castleman's disease
BRITISH JOURNAL OF HAEMATOLOGY,99(4):981-982 1997
Author:Ishida, F; Kitano, K; Kobayashi, H; Saito, H; Kiyosawa, K

Eosinophilia associated with proliferation of CD3(+)4(-)8(-) alpha beta(+) T cells with chromosome 16 anomalies
BRITISH JOURNAL OF HAEMATOLOGY,92(2):315-317 1996
Author:Kitano, K; Ichikawa, N; Mahbub, B; Ueno, M; Ito, T; Shimodaira, S; Kodaira, H; Ishida, F; Kobayashi, H; Saito, H; Okubo, Y; Enokihara, H; Kiyosawa, K

Serum thrombopoietin (c-mpl ligand) levels in patients with liver cirrhosis
BRITISH JOURNAL OF HAEMATOLOGY,93:1033-1033 1996
Author:Kitano, K; Shimodaira, S; Ishida, F; Ichikawa, N; Kodaira, H; Ito, T; Tahara, T; Kato, T; Kiyosawa, K

Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anemia and idiopathic thrombocytopenic purpura.
EXPERIMENTAL HEMATOLOGY,24(9):428-428 1996
Author:Ichikawa, N; Ishida, F; Shimodaira, S; Ito, T; Tahara, T; Kato, T; Kitano, K

Serum thrombopoietin (c-Mpl ligand) levels in patients with liver cirrhosis
THROMBOSIS AND HAEMOSTASIS,76(4):545-548 1996
Author:Shimodaira, S; Ishida, F; Ichikawa, N; Tahara, T; Kato, T; Kodaira, H; Ito, T; Tanaka, E; Sodeyama, T; Kiyosawa, K; Kitano, K

The largest isoform of platelet membrane glycoprotein Ib?lpha is commonly distributed in eastern Asian populations
Thromb Haemost,76:245-247 1996
Author:Ishida F/ Furihata K

Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenic purpura
Thromb Haemost,76(2):156-160 1996
Author:Ichikawa N/ Ishida F

Serum thrombopoietin(C-Mpl ligand) levels in patients with liver cirrhosis
Thromb Haemost,76:545-548 1996
Author:Shimodaira S/ Ishida F

血小板膜糖蛋白 (GP) Ibαの多型
日本血栓止血学会誌 = The Journal of Japanese Society on Thrombosis and Hemostasis,6(6):442-452 1995(Dec. 01)
Author:石田文宏; 降旗謙一;
Keywords:glycoprotein Ibα; polymorphism; HPA-2; tandem repeat; linkage disequilibrium;

THE DETECTION OF CLONAL PROLIFERATION IN GRANULAR LYMPHOCYTE-PROLIFERATIVE DISORDERS OF NATURAL-KILLER-CELL LINEAGE
BRITISH JOURNAL OF HAEMATOLOGY,90(3):578-584 1995
Author:SHIMODAIRA, S; ISHIDA, F; KOBAYASHI, H; MAHBUB, B; KAWAHA, K; KITANO, K

THE LARGEST VARIANT OF PLATELET GLYCOPROTEIN IB-ALPHA HAS 4 TANDEM REPEATS OF 13 AMINO-ACIDS IN THE MACROGLYCOPEPTIDE REGION AND A GENETIC-LINKAGE WITH METHIONINE
BLOOD,86(4):1356-1360 1995
Author:ISHIDA, F; FURIHATA, K; ISHIDA, K; YAN, J; KITANO, K; KIYOSAWA, K; FURUTA, S

APC-RESISTANCE AND MNL-I GENOTYPE (GLN-506) OF COAGULATION-FACTOR-V ARE RARE IN JAPANESE POPULATION
THROMBOSIS AND HAEMOSTASIS,74(3):996-996 1995
Author:TAKAMIYA, O; ISHIDA, F; KODAIRA, H; KITANO, K

Arg 506 Gln factor V mutation is uncommon in eastern Asian populations.
BLOOD,86(10):3658-3658 1995
Author:Kodaira, H; Ishida, F; Ito, T; Ichikawa, N; Shimofaira, S; Takamiya, O; Furihata, K; Kiyosawa, K; Kitano, K

TRANSFUSION-ASSOCIATED GRAFT-VERSUS-HOST DISEASE IN AN IMMUNOCOMPETENT PATIENT FOLLOWING ACCIDENTAL INJURY
AMERICAN JOURNAL OF HEMATOLOGY,43(1):51-53 1993
Author:KOBAYASHI, H; KITANO, K; KISHI, E; HARA, K; ISHIDA, F; SAITO, H; OTA, M; FURUTA, S

EOSINOPHILIA IN MYELODYSPLASTIC SYNDROME WITH A (12 21)(Q23 Q22) TRANSLOCATION
CANCER GENETICS AND CYTOGENETICS,68(2):95-98 1993
Author:KOBAYASHI, H; KITANO, K; SHIMODAIRA, S; ISHIDA, F; SAITO, H; SONOYAMA, M; ENOKIHARA, H; FURUTA, S

APLASTIC-ANEMIA AND IDIOPATHIC THROMBOCYTOPENIC PURPURA WITH ANTIBODY TO PLATELET GLYCOPROTEIN IIB/IIIA FOLLOWING RESECTION OF MALIGNANT THYMOMA
ACTA HAEMATOLOGICA,90(1):42-45 1993
Author:KOBAYASHI, H; KITANO, K; ISHIDA, F; SAITO, H; MIYABAYASHI, H; YONEZAWA, T; INADA, H; SUZUKI, A; FURUTA, S

GENETIC AND STRUCTURAL CHARACTERIZATION OF AN AMINO-ACID DIMORPHISM IN GLYCOPROTEIN IB-ALPHA INVOLVED IN PLATELET TRANSFUSION REFRACTORINESS
BLOOD,79(11):3086-3090 1992
Author:MURATA, M; FURIHATA, K; ISHIDA, F; RUSSELL, SR; WARE, J; RUGGERI, ZM

HUMAN PLATELET-SPECIFIC ANTIGEN, SIB(A), IS ASSOCIATED WITH THE MOLECULAR-WEIGHT POLYMORPHISM OF GLYCOPROTEIN-IB-ALPHA
BLOOD,78(7):1722-1729 1991
Author:ISHIDA, F; SAJI, H; MARUYA, E; FURIHATA, K

Ｍｏｄｉｆｉｅｄ　ａｎｔｉｇｅｎ‐ｃａｐｔｕｒｅ　ＥＬＩＳＡによる血小板同種抗原Ｂｒ｀ａ´／Ｂｒ｀ｂ´の検出
日本輸血学会雑誌,36(6):713-716 1990
Author:石田文宏; 緒方洪之; 古田精市; 降旗謙一;
Abstract:A platelet alloantigen system, Br^a/Br^b, is defined recently and is implicated in several cases of neonatal alloimmune thrombocytopenic purpura (NATP) in Europe. Since each platelet has only 1, 000-2, 000 molecules of Br^aBr^b antigens, it is very hard to phenotype platelets by methods in which whole platelets are used as antigens. In this study, we employed modified antigen-capture ELISA (MACE) to phenotype platelets for Br^a/Br^b. Platelets were easily phenotyped qualitatively and semiquantitatively by MACE in which a murine monoclonal anti-glycoprotein (GP) IIa (4B4; CD29) was used to capture GP Ia-IIa complex. Phenotypic frequencies of Br^a and Br^b among 67 Japanese were 11.7% and over 98.3%, respectively. Their frequencies among Japanese were significantly differed from those among Caucasians and chilean Indians. Br^a/Br^b antigen system would be responsible for some cases of NATP and platelet transfusion refractoriness in Japan. MACE would be extremely useful to identify Br^a/Br^b incompatibility in those cases.

IL-2添加による染色体分析で47XY, +8の異常を認めたnatural killer細胞型granular lymphocyte leukemia
臨床血液,31(10):1711-1715 1990
Author:石田文宏; 斉藤博; 降旗謙一; 古田精市; 園山政行; 押味和夫;
Abstract:A 28-year-old male was admitted to our hospital because of hepatosplenomegaly and granular lymphocytosis. His peripheral leukocyte count was 3,000/μl with 43% of granular lymphocytes (GL). These GLs were immunologically phenotyped as CD2⁺CD3^-CD4^-CD8^-CD16⁺CD56⁺HLA-DR⁺ and were found that TcR genes coding beta and gamma chains were not rearranged. Chromosomal analysis of his GLs stimulated with IL-2 showed 47 XY, +8. This patient was diagnosed as a granular lymphocyte leukemia of natural killer cell type. Blood chemistry showed elevation of serum GOT, GPT and LDH values. The fever persisted until administration of prednisolone was initiated. But 40 days after, high fever appeared again and the liver and spleen were extremely enlarged. Combined chemotherapy was then started but resulted in no effects. He died of hepatic failure on the 77th day from admission. 47 XY, +8, that has been reported in acute non-lymphocytic leukemia and myelodysplastic syndrome, may be related to the pathogenesis in some cases of granular lymphocyte leukemia.
Keywords:granular lymphocyte leukemia; natural killer cell; 47 XY; +8;

A Missense Mutation (Tyr88 to Cys) in the Platelet Membrane Glycoprotein Ib?eta gene affects the expression of GPIb/IX complex expression
Thromb Haemost
Author:Kurokawa Y/ Ishida F

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