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KANNO Hiroyuki

Academic OrganizationAcademic Assembly School of Medicine and Health Sciences Institute of MedicineTEL+81-263-37-2608
Education and Research OrganizationSchool of Medicine Department of PathologyFAX+81-263-37-2609
Address3-1-1 Asahi, Matsumoto, Nagano 390-8621Web site


Assigned Class
Graduate School of Medicine
Research Field
Experimental pathology
Keywords:Connective tissue disease , Vasculitis , Epstein-Barr virus , malignant lymphoma , immune disease
Current Subject
immune disorder caused by Epstein-Barr virus infection
Keywords:Epstein-Barr virus , immune disorder , cytokine , endothelial cell , 平成23年度-
Academic Societies
Academic Societies
Japanese Society of Pathology
Japanese college of Rheumatology
Academic Background
Graduate School
Tohoku University , (Graduate School of Medicine) , 1990

Tohoku University , (School of Medicine) , 1986

Doctor of Medical Science , Tohoku University
Research Career
Research Career
2011- , Professor, Shinshu University School of Medicine
2002-2011 , Associate Professor, Iwate Medical University
2000-2002 , Associate Professor, Hokkaido University Institute for Genetic Medicine
1993-1999 , Assistent Professor and Associate Professor, Osaka University Medical School

Overseas Education
1990-1993 , National Institute of Allergy and Infectious Diseases


Books, Articles, etc.
Histological and immunohistochemical evaluation of infiltrating inflammatory cells in Kawasaki disease arteritis lesions.
Appl. Immunohistochem. Mol. Morphol.,29(1):62-67 2021(Jan.)
Author:Kobayashi M, Matsumoto Y, Ohya M, Harada K, Kanno H

An anaplastic pleomorphic xanthoastrocytoma with periventricular extension: an autopsy scase report amd review of the literature.
Neuropathology,40:507-514 2020(Oct.)
Author:Matsumoto Y, Kobayashi M, Shingu K, Tateishi A, Ohya M, Sano K, Negishi T, Shigeto S, Kobayashi T, Hara Y, Kakizawa Y, Kanno H

The ratio of CD163-positive macrophages to Iba 1-positive macrophages is low in the intima in the early stage of cutaneous arteritis.
Immunologic Res.,68(3):152-160 2020(Jun.)
Author:Kobayashi M, Matsumoto Y, Satomi H, Tateishi A, Ohya M, Ito I, Kanno H

Ultrastructure of CIC-DUX4 sarcoma: the first pathological report.
Ultrastruct. Pathol.,44(2):237-277 2020(Mar.)
Author:Tamada H, Kobayashi M, Sano K, Uehara T, Matsumoto Y, Tateishi A, Ohya M, Kito M, Aoki K, Kanno H

Automated acquisition of explainable knowledge from unannotated histopathology images.
Nature Communications,10(1):5642 2019(Dec.)
Author:Yamamoto Y, Tsuzuki T, Akatsuka J, Ueki M, Morikawa H, Numata Y, Takahara T, Tsuyuki T, Tsutsumi K, Nakazawa R, Shimizu A, Maeda I, Tsuchiya S, Kanno H, Kondo Y, Fukumoto M, Tamiya G, Ueda N, Kimura G

Malignant peritoneal mesothelioma diagnosed 50 years post-radiotherapy for ovarian cancer in a patient with a history of multiple malignancies: An autopsy case.
Molecular and Clinical Oncology,11(4):397-400 2019(Oct.)
Author:Ohya M, Kobayashi M, Suzuki T, Kanno H, Nakazawa K.

An autopsy case of widespread brain dissemination of glioblastoma unnoticed by magnetic resonance imaging after treatment with bevacizymab.
Surgical Neurology International,10:137 2019(Jul.)
Author:Hardian RF, Goto T, Kuwabara H, Hanaoka Y, Kobayashi S, Kanno H, Shimojo H, Horiuchi T, Hongo K.

A fulminant case of classical Hodgkin lymphoma: a diagnostic dilemma of Epstein-Barr virus-positive large B-cell neoplasms.
Pathology Internaional,69(7):407-413 2019(Jul.)
Author:Ichimata S, Kobayashi M, Ohya M, Otsuki T, Yanagisawa K, Tateishi K, Kato A, Matsuo A, Kanno H

Cell biological profiling of reprogrammed cancer stem cell-like colon cancer cells maintained in culture
CELL AND TISSUE RESEARCH,375(3):697-707 2019(Mar.)
Author:Hirashima, Kanji; Yue, Fengming; Kobayashi, Mikiko; Uchida, Yuriko; Nakamura, Shunsuke; Tomotsune, Daihachiro; Matsumoto, Ken; Takizawa-Shirasawa, Sakiko; Yokoyama, Tadayuki; Kanno, Hiroyuki; Sasaki, Katsunori;

Effects of Morinda citrifolia on Rheumatoid Arthritis in SKG Mice
Author:Kustiarini, Dyah Aninta; Nishigaki, Toshiaki; Kanno, Hiroyuki; To, Hideto;

Lower number of 5-hydroxymethylcytosine-expressing cells in plasma cell myeloma than in reactive plasma cell hyperplasia: a useful immunohistochemical approach for identification of neoplastic plasma cells
PATHOLOGY,51(1):81-85 2019(Jan.)
Author:Ohya, Maki; Nakazawa, Koh; Kanno, Hiroyuki;

Usefulness of gastroduodenal biopsy in the differential diagnosis of systemic AH amyloidosis from systemic AL amyloidosis
HISTOPATHOLOGY,73(2):230-239 2018(Aug.)
Author:Ichimata, Shojiro; Kobayashi, Mikiko; Shimojo, Hisashi; Katoh, Nagaaki; Yazaki, Masahide; Kanno, Hiroyuki;

First pathological report of a de novo CD5-positive diffuse large B-cell lymphoma patient presenting with Guillain-Barre syndrome-like neuropathy due to neurolymphomatosis
NEUROPATHOLOGY,38(4):417-421 2018(Aug.)
Author:Kobayashi, Mikiko; Sakai, Yasuhiro; Kariya, Yuta; Sakai, Hitoshi; Hineno, Akiyo; Oyanagi, Kiyomitsu; Kanno, Hiroyuki;

Induction of Interleukin-10 in the Stable Transformants of Human T-Cell Line Expressing Epstein-Barr Virus-Encoded Small RNAs
信州医学雑誌,66(3):195-204 2018(Jun. 10)
Author:Junaidi Ayako Tateishi, Hiroyuki Kanno

Histopathological findings of pregnancy-induced hypertension: histopathology of early-onset type reflects two-stage disorder theory
VIRCHOWS ARCHIV,472(4):635-642 2018(Apr.)
Author:Tateishi, Ayako; Ohira, Satoshi; Yamamoto, Yoichiro; Kanno, Hiroyuki;

Impact of the genetic variants of GLCC11 on clinical features of asthmatic patients.
Clinical Respiratory Journal,12(3):1166 2018
Author:Chiba S, Nakamura Y, Mizuno T, Abe K, Horii Y, Nagashima H, Sasaki N, Kanno H, Tanita T, Yamauchi K.

In vasculitis of small muscular arteries, activation of vessel-infiltrating CD8 T cells seems to be antigen-independent.
Virchows Archiev,472(2):271 2018
Author:Kobayashi M, Ogawa E, Okuyama R, Kanno H

Acquired amegakaryocytic thrombocytopenia with autoantibodies to thrombopoietin receptor (c-Mpl) in a patient with hepatitis C virus infection.
World Journal of Gastroenterology,23(35):6540 2017
Author:Ichimata S, Kobayashi M, Honda K, Shibata S, Matsumoto A, Kanno H.

Quantitative diagnosis of breast tumors by morphometric classification of microenvironmental myoepithelial cells using a machine learning approach.
Scientific Reports,7:46732 2017
Author:Yamamoto Y, Saito A, Tateishi A, Shimojo H, Kanno H, Tsuchiya S, Ito K, Cosatto E, Graf HP, Moraleda RR, Elis R, Grabe N.

Axonal TDP-43 aggregates in sporadic amyotrophic lateral sclerosis.
Neuropathol. Appl. Neurobiol.,42(6):561-572 2016
Author:Onozato T, Nakahara A, Suzuki-Kouyama E, Hineno A, Yasuda T, Nakamura T, Yahikozawa H, Watanabe M, Kayanuma K, Makishita H, Ohara S, Hashimoto T, Higuchi K, Sakai T, AsanoK, Hashimoto T, Kanno H, Nakayama J, Oyanagi K.

Therapeutic implication of genetic variants of IL13 and STAT4 in airway remodelling with bronchial asthma
Clinical and Experimental Allergy,46(9):1152-1161 2016
Author:6. Nakamura Y, Suzuki R, Mizuno T, Abe K, Chiba S, Horii Y, Tsuboi J, Ito S, Obara W, Tanita T, Kanno H, Yamauchi K

Tumor and immune cell dynamics explain the PSA bounce after prostate cancer brachytherapy
British Journal of Cancer,115:195-202 2016
Author:7. Yamamoto Y, Offord CP, Kimura G, Kuribayashi S, Takeda H, Tsuchiya S, Shimojo H, Kanno H, Bozic I, Nowak M, Bajzer Z, Dingli D

Late-onset rejection of a unilateral donor lung with vascular C4d deposition in bilateral living-donor lobar lung transplantation: An autopsy case report.
Intern Medicine,53:1645-1650 2014
Author:Yamamoto H, Yoshida K, Koizumi T, Tokoro Y, Fukushima T, Tateishi K, Ushiki A, Yokoyama T, Yasuo M, Urushihara K, Hanaoka M, Shingu K, Shimojo H, Kanno H, Yoshizawa A, Kawakami S, Miyagawa-Hayashino A, Date H, Kubo K

World’s first telepathology experiments employing ultra-high-speed internet satellite, nicknamed “KIZUNA”.
Journal of Pathology Informatics,4:24 2013
Author:5. Sawai, T., Uzuki, M., Miura, Y., Kamataki, A., Matsumura, T., Saito, K., Kurose, A., Osamura, Y. R., Yoshimi, N., Kanno, H., Moriya, T., Ishida, Y., Satoh, Y., Nakao, M., Ogawa, E., Matsuo, S., Kasai, H., Kumagai, K., Motoda, T., and Hopson, N.

Polymyxins as novel and safe mucosal adjuvants to induce humoral immune responses in mice.
PLOS ONE,8:e61643 2013
Author:6. Yoshino, N., Endo, M., Kanno, H., Matsukawa, N., Tsutsumi, R., Takeshita, R., and Sato, S.

Prospective randomized controlled study comparing cell block method and conventional smear method for pancreatic juice cytology.
Digestive Endoscopy,24(3):168-174 2012
Author:Noda Y, Fujita N, Kobayashi G, Ito K, Horaguchi J, Obana T, Koshita S, Kanno Y, Yamashita Y, Kato Y, Ogawa T, Tsuchiya T, Oikawa M, Sawai T, Kanno H, and Kurose A.

Mucosal immune responses in W/Wv and Sl/Sld munant mice.
Experimental Animals,61(4):407-416 2012
Author:Yoshino, N., Kanno, H., Takahashi, K., Endo, M., and Sato, S.

Effect of genetic variation of IL-13 on airway remodeling in bronchial asthma.
Allergology International,60(3):291-298 2011
Author:Nagashima, H., Nakamura, Y., Kanno, H., Sawai, T., Inoue, H., and Yamauchi, K.

Systemic sclerosis presented as congestive heart failure: an autopsy case.
Modern Rheumatol.,21(4):423-427 2011
Author:Kanno, H., Segawa, T., Miura, Y., Miyata, M., Yoshida, A., Nakamura, M., and Sawai, T.

Heavy chain amyloidosis in gastroduodenal biopsies-the histopathological features-
XVIth International Symposium on Amyloidosis 2018(Mar. 27)
Presenter:Ichimata S, Kobayashi M, Shimojo H, Katoh N, Yazaki M, Kanno H.

Intestinal Ischemia due to vasculitis following the reactivation of Epstein-Barr virus infection.
18th International Vasculitis and ANCA Workshop: Diversity and Integration for Tomorrow 2017(Mar. 25)
Presenter:Ichimata, S., Ishigame, H., Mitsuishi, T., Yamamoto, K., and Kanno, H

Predominant infiltration of CD8 T cells activated in antigen-independent manner in vasculitis of small muscular arteries.
18th International Vasculitis and ANCA Workshop: Diversity and Integration for Tomorrow 2017(Mar. 25)
Presenter:Kobayashi, M., Ogawa, E., Okuyama, R., and Kanno, H.

Increased adhesion of Epstein-Berr virus-encoded small RNA-expressing T cells to cultured endothelial cells.
The Asia Paciffic meeting of vasculitis and ANCA workshop 2012 2012( 3/)
Presenter:Kanno, H., and Sawai, T.

Research Activities
Journal Editorial Board
2010-2019 , 日本病理学会
2013- , 日本臨床リウマチ学会

Journal Reviewer
2011- , 日本病理学会
2008- , 日本リウマチ学会

Overseas Research Fellowship
2001-2001 , 文部省短期在外研究員(海外研究開発動向調査派遣)


International Student Receipt
2020 , First Term:1 , Second Term:1
2019 , First Term:1 , Second Term:1
2017 , First Term:1 , Second Term:1
2016 , First Term:1 , Second Term:1
2015 , First Term:1 , Second Term:1
2014 , First Term:1 , Second Term:1
2013 , First Term:0 , Second Term:1