MOTOKI, NORIKO | Shinshu University Researcher Directory

Academic Organization		TEL	+81-263-37-2642
Education and Research Organization	School of Medicine　Department of Pediatrics	FAX	+81-263-37-3089
Position	Senior Assistant Professor	Mail Address
Address	3-1-1, Asahi, Matsumoto City 390-8621	Web site

Profile

Research Field: Pediatric cardiology
Keywords:Pediatric Cardiology

Academic Societies: Academic Societies
日本小児科学会、日本小児循環器学会
日本公衆衛生学会

Academic Background: College
信州大学 , 1998

Degree
医学博士 , 信州大学

Research

Books, Articles, etc.: Articles
Identification of metabolomic profile related to adult Fontan pathophysiology
Int J Cardiol Heart Vasc.,24(37):100921 2022(Nov.)
Author:Motoki N, Motoki H, Utsumi M, Yamazaki S, Obinata H, Takei K, Yasukochi S.

Combination Therapy of Cyclosporin A and Plasma Exchange for Infants with Immunoglobulin-resistant Kawasaki Disease
Shinshu Medical Journal,70(4):225-231 2022(Aug.)
Author:Yokota Saori, Motoki Noriko, Yamazaki Shoko, Utsumi Masafumi

Impact of maternal dyslipidemia on infant neurodevelopment: The Japan Environment and Children's Study
Brain Dev 2022(May)
Author:Motoki N, Inaba Y, Shibazaki T, Misawa Y, Ohira S, Kanai M, Kurita H, Tsukahara T, Nomiyama T; Japan Environment, Children's Study (JECS) Group.

Insufficient maternal gestational weight gain and infant neurodevelopment at 12 months of age: the Japan Environment and Children's Study
EUROPEAN JOURNAL OF PEDIATRICS,181(3):921-931 2022(Mar.)
Author:Motoki, Noriko; Inaba, Yuji; Shibazaki, Takumi; Misawa, Yuka; Ohira, Satoshi; Kanai, Makoto; Kurita, Hiroshi; Tsukahara, Teruomi; Nomiyama, Tetsuo; Japan Environm Childrens Study JEC;
Keywords:Gestational weight gain; Infant; Neurodevelopment; Developmental delay; ASQ-3;

Myocardial ischemia during methylprednisolone pulse therapy with dipyridamole
PEDIATRICS INTERNATIONAL,63(6):722-723 2021(Jun.)
Author:Tsukahara, Takanori; Matsuoka, Daisuke; Shimada, Shun; Hachiya, Akira; Motoki, Noriko;
Keywords:cytochrome P-450 CYP3A4; dipyridamole; IgA nephropathy; methylprednisolone pulse therapy; myocardial ischemia;

幼児の睡眠の問題と母親の睡眠行動・養育環境の関係
信州公衆衛生雑誌,15(2):45-54 2021(Apr.)
Author:元木倫子, 島﨑雅士, 上條怜音, 笹尾祐介, 中込健斗, 中村真波, 新田温生, 白旭坤, 星野彰太郎, 松井寛郎, 山口廉之亮, 吉田真介, 吉田真介, 長谷川航平, 當房浩一, 水木将, 上條知子, 塚原照臣, 野見山哲生

Predictive factors of poor blood collecting flow during leukocyte apheresis for cellular therapy
THERAPEUTIC APHERESIS AND DIALYSIS 2021
Author:Konno, Saori; Yanagisawa, Ryu; Motoki, Noriko; Shimodaira, Shigetaka;
Keywords:blood donation; cellular therapy; harvesting; leukapheresis; QT dispersion;

Relationship between placental weight and late-onset circulatory collapse
PEDIATRICS INTERNATIONAL 2021
Author:Nakamura, Chizuko; Miyosawa, Yukihide; Motoki, Noriko; Yanagisawa, Toshimitsu; Hirabayashi, Kanae; Ishida, Takefumi; Nakazawa, Yozo; Nakamura, Tomohiko;
Keywords:birthweight to placental weight ratio; late-onset circulatory collapse; neonate; placental weight; preterm;

A Neonatal Transient Myocardial Ischemia Case with Severe Left Heart Failure Detected by Saturation of Percutaneous Oxygen Measurement in Both the Upper and Lower Limbs
Shinshu Medical Journal,68(4):203-208 2020(Aug. 10)
Author:ITO Kaori;HACHIYA Akira;MOTOKI Noriko
Abstract:Neonatal transient myocardial ischemia (TMI) is a rare disease, and is known in term infants to show cyanosis, congestive heart failure, and acute left heart failure after birth, which needs differential diagnosis from severe congenital heart disease.
We describe the case of a 2898g female term neonate with TMI. The course of pregnancy and delivery was normal. Because of a slow increase of saturation of percutaneous oxygen (SpO₂) in the lower limbs, she required oxygen administration, and was admitted to the neonatal intensive care unit. Echocardiography revealed no cardiac malformations, but the left ventricular function was markedly reduced (left ventricular fractional shortening 14.5%). Moreover, right to left shunts in the ductus arteriosus and retrograde aortic arch blood flow were observed. Brain natriuretic peptide (BNP) was 888.5pg/ml. She was dependent on dopamine, dobutamine and phosphodiesterase-3 inhibitors to keep blood pressure in the normal range. At the age of 1 day, the left ventricular systolic function improved, and almost normalized at 3 days. After the drug infusions were discontinued, normal cardiac function was maintained, and she was discharged at the age of 14 days.
As diseases exhibiting a difference in SpO₂ in the upper and lower limbs after birth, congenital heart diseases such as aortic stenosis, and persistent pulmonary hypertension of newborns are well known. However, right-to-left shunting ductus arteriosus was considered to be one of the pathological conditions that could be observed in newborns with severe low cardiac output. SpO₂ measurement in both the upper and lower limbs seems to be useful for early diagnosis of severe TMI.

Association between pesticide usage during pregnancy and neonatal hyperbilirubinemia requiring treatment: the Japan Environment and Children's Study.
2020(Aug. 05)
Author:1)Shibazaki T, Motoki N, Misawa Y, Ohira S, Inaba Y, Kanai M, Kurita H, Nakazawa Y, Tsukahara T, Nomiyama T; Japan Environment & Children’s Study (JECS) Group.

Heart rate variability in the course of chemotherapy and heamatopoietic stem cell transplantation for peadiatric patients with haematological malignancies.
Cardiology in the Young,30(7):967-974 2020(Jul.)
Author:3)Kobayashi H, Motoki N, Yokota S, Kanai A, Yamazaki S, Utsumi M, Nakazawa Y.

Impact of Infliximab Administration Before Plasma Exchange Therapy on Patients With Kawasaki Disease
Ther Apher Dial.,doi: 10.1111/1744-9987.13486. 2020(Feb. 19)
Author:Shimada S, Matsuoka D, Murase T, Hachiya A, Motoki N, Nakazawa Y.

Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children's Study
PEDIATRIC RESEARCH 2020
Author:Kurita, Hiroshi; Motoki, Noriko; Inaba, Yuji; Misawa, Yuka; Ohira, Satoshi; Kanai, Makoto; Tsukahara, Teruomi; Nomiyama, Tetsuo; Japan Environm Children's Study;

Transient Q-waves in an infant with asymptomatic myocardial infarction due to Kawasaki disease
CARDIOLOGY IN THE YOUNG,29(2):231-234 2019(Feb.)
Author:Akagawa, Daisuke; Motoki, Noriko; Hachiya, Akira; Akazawa, Yohei;

A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease
PEDIATRIC RHEUMATOLOGY,17 2019
Author:Amano, Yuji; Akazawa, Yohei; Yasuda, Jun; Yoshino, Kazuhisa; Kojima, Katsuhiko; Kobayashi, Norimoto; Matsuzaki, Satoshi; Nagasaki, Masao; Kawai, Yosuke; Minegishi, Naoko; Ishida, Noriko; Motoki, Noriko; Hachiya, Akira; Nakazawa, Yozo; Yamamoto, Masayuki; Koike, Kenichi; Takeshita, Toshikazu;

Alcohol Consumption During Pregnancy and Risk of Placental Abnormality: The Japan Environment and Children's Study
SCIENTIFIC REPORTS,9 2019
Author:Ohira, Satoshi; Motoki, Noriko; Shibazaki, Takumi; Misawa, Yuka; Inaba, Yuji; Kanai, Makoto; Kurita, Hiroshi; Shiozawa, Tanri; Nakazawa, Yozo; Tsukahara, Teruomi; Nomiyama, Tetsuo; Kawamoto, Toshihiro; Saito, Hirohisa; Kishi, Reiko; Yaegashi, Nobuo; Hashimoto, Koichi; Mori, Chisato; Ito, Shuichi; Yamagata, Zentaro; Inadera, Hidekuni; Kamijima, Michihiro; Nakayama, Takeo; Iso, Hiroyasu; Shima, Masayuki; Hirooka, Yasuaki; Suganuma, Narufumi; Kusuhara, Koichi; Katoh, Takahiko; Japan Environm Childrens Study JEC;

Maternal Exposure to Housing Renovation During Pregnancy and Risk of Offspring with Congenital Malformation: The Japan Environment and Children's Study
SCIENTIFIC REPORTS,9 2019
Author:Motoki, Noriko; Inaba, Yuji; Shibazaki, Takumi; Misawa, Yuka; Ohira, Satoshi; Kanai, Makoto; Kurita, Hiroshi; Nakazawa, Yozo; Tsukahara, Teruomi; Nomiyama, Tetsuo; Kawamoto, Toshihiro; Saito, Hirohisa; Kishi, Reiko; Yaegashi, Nobuo; Hashimoto, Koichi; Mori, Chisato; Ito, Shuichi; Yamagata, Zentaro; Inadera, Hidekuni; Kamijima, Michihiro; Nakayama, Takeo; Iso, Hiroyasu; Shima, Masayuki; Hirooka, Yasuaki; Suganuma, Narufumi; Kusuhara, Koichi; Katoh, Takahiko; Japan Environm Childrens Study JEC;

Decreased Circulating Insulin-Like Growth Factor 1 Levels Are Associated with Cardiac Diastolic Dysfunction in Small for Gestational Age Infants
AMERICAN JOURNAL OF PERINATOLOGY,35(12):1178-1185 2018(Oct.)
Author:Akazawa, Yohei; Yamazaki, Shoko; Obinata, Haruka; Hachiya, Akira; Kamiya, Motoko; Motoki, Noriko; Nakamura, Tomohiko;

Analysis of biomarker serum levels in IVIG and infliximab refractory Kawasaki disease patients
CLINICAL RHEUMATOLOGY,37(7):1937-1943 2018(Jul.)
Author:Hachiya, Akira; Kobayashi, Norimoto; Matsuzaki, Satoshi; Takeuchi, Yusuke; Akazawa, Yohei; Shigemura, Tomonari; Motoki, Noriko; Masumoto, Junya; Agematsu, Kazunaga;

Association of Severity of Coronary Artery Aneurysms in Patients With Kawasaki Disease and Risk of Later Coronary Events
JAMA PEDIATRICS,172(5) 2018(May)
Author:Miura, Masaru; Kobayashi, Tohru; Kaneko, Tetsuji; Ayusawa, Mamoru; Fukazawa, Ryuji; Fukushima, Naoya; Fuse, Shigeto; Hamaoka, Kenji; Hirono, Keiichi; Kato, Taichi; Mitani, Yoshihide; Sato, Seiichi; Shimoyama, Shinya; Shiono, Junko; Suda, Kenji; Suzuki, Hiroshi; Maeda, Jun; Waki, Kenji; Kato, Hitoshi; Saji, Tsutomu; Yamagishi, Hiroyuki; Ozeki, Aya; Tomotsune, Masako; Yoshida, Makiko; Akazawa, Yohei; Aso, Kentaro; Doi, Shouzaburoh; Fukasawa, Yoshi; Furuno, Kenji; Hayabuchi, Yasunobu; Hayashi, Miyuki; Honda, Takafumi; Horita, Norihisa; Ikeda, Kazuyuki; Ishii, Masahiro; Iwashima, Satoru; Kamada, Masahiro; Kaneko, Masahide; Katyama, Hiroshi; Kawamura, Yoichi; Kitagawa, Atushi; Komori, Akiko; Kuraishi, Kenji; Masuda, Hiroshi; Matsuda, Shinichi; Matsuzaki, Satoshi; Mii, Sayaka; Miyamoto, Tomoyuki; Moritou, Yuji; Motoki, Noriko; Nagumo, Kiyoshi; Nakamura, Tsuneyuki; Nishihara, Eiki; Nomura, Yuichi; Ogata, Shohei; Ohashi, Hiroyuki; Okumura, Kenichi; Omori, Daisuke; Sano, Tetsuya; Suganuma, Eisuke; Takahashi, Tsutomu; Takatsuki, Shinichi; Takeda, Atsuhito; Terai, Masaru; Toyono, Manatomo; Watanabe, Kenichi; Watanabe, Makoto; Yamamoto, Masaki; Yamamura, Kenichiro; Doi, Shozaburo; Fukasawa, Yoshie; Katayama, Hiroshi; Z Score Project 2nd Stage Study Gr;

Sudden improvement in ventricular repolarization abnormality after a short detraining period in an athlete.
2017(Jun. 27)
Author:元木倫子、赤澤陽平、蜂谷明、稲葉雄二

Left ventricular non-compaction revealed by aortic regurgitation due to Kawasaki disease in a boy with LDB3 mutation
PEDIATRICS INTERNATIONAL,58(8):797-800 2016(Aug.)
Author:Hachiya, Akira; Motoki, Noriko; Akazawa, Yohei; Matsuzaki, Satoshi; Hirono, Keiichi; Hata, Yukiko; Nishida, Naoki; Ichida, Fukiko; Koike, Kenichi;

Successful treatment of arrhythmia-induced cardiomyopathy in an infant with tuberous sclerosis complex.
2016
Author:Motoki N, Inaba Y, Matsuzaki S, Akazawa Y, Nishimura T, Fukuyama T, Koike K

Increased pretransplant QT dispersion as a risk factor for the development of cardiac complications during and after preparative conditioning for pediatric allogeneic hematopoietic stem cell transplantation
PEDIATRIC TRANSPLANTATION,14(8):986-992 2010(Dec.)
Author:Motoki, Noriko; Shimizu, Takashi; Akazawa, Yohei; Saito, Shoji; Tanaka, Miyuki; Yanagisawa, Ryu; Motoki, Hirohiko; Nakazawa, Yozo; Sakashita, Kazuo; Iwasaki, Yasushi; Shiohara, Masaaki; Koike, Kenichi;

Clinical Profiles of Adult Patients With Single Ventricular Physiology
CIRCULATION JOURNAL,73(9):1711-1716 2009(Sep.)
Author:Motoki, Noriko; Ohuchi, Hideo; Miyazaki, Aya; Yamada, Osamu;

Presentations
Prognostic significance of QT interval dispersion in the response of intravenous immunoglobulin therapy in patients with Kawasaki disease
2016(Nov. 13)
Presenter:Noriko Motoki, Yohei Akazawa, Shoko Yamazaki, Akira Hachiya, Hirohiko Motoki, Satoshi Matsuzaki, Kenichi Koike.

Research Grants: Grants‐in‐aid for Scientific Research(Research Representative)
2018 - 2020 , メタボローム解析によるフォンタン術後単心室患者の代謝特性の解明 , 若手研究

Shinshu University Researcher Directory

MOTOKI NORIKO

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MOTOKI　NORIKO