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Shigemori Suguru

Academic OrganizationTEL
Education and Research OrganizationInterdisciplinary Cluster for Cutting Edge Research Institute for Biomedical SciencesFAX
PositionAssistant ProfessorMail Addressshigemoris@shinshu-u.ac.jp
Address8304, Minamiminowa-Village, Kamiina-County 399-4598Web sitehttp://www.shinshu-u.ac.jp/faculty/agriculture/lab/shimolab/index.html

Profile

Research Field
Keywords:Lactic acid bacteria , Probiotics , Genetically modified lactic acid bacteria (gmLAB) , Immunomodulatory oligodeoxynucleotide , Gut ecosysytem , "Gut Ecobiotics" , Mice
Current Subject
Advocating "Gut Ecobiotics"
Keywords:Probiotic lactic acid bacteria , Gut ecosystem , Mice

Research

Books, Articles, etc.
Articles
Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17
FRONTIERS IN NUTRITION,7:610946 2021(Feb.)
Author:Mikami, Ayane; Ogita, Tasuku; Namai, Fu; Shigemori, Suguru; Sato, Takashi; Shimosato, Takeshi;
Keywords:Flavonifractor plautii; green tea; inflammatory bowel disease; IL-17; lipoteichoic acid;


Construction of Genetically Modified Lactococcus lactis Producing Anti-human-CTLA-4 Single-Chain Fragment Variable
MOLECULAR BIOTECHNOLOGY,62(11-12):572-579 2020(Dec.)
Author:Namai, Fu; Murakami, Aito; Ueda, Asami; Tsukagoshi, Masami; Shigemori, Suguru; Ogita, Tasuku; Sato, Takashi; Shimosato, Takeshi;
Keywords:gmLAB; Next-generation probiotics; Lactococcus lactis; Single-chain fragment variable; CTLA-4; NICE system;


Nasally Administered Lactococcus lactis Secreting Heme Oxygenase-1 Attenuates Murine Emphysema
ANTIOXIDANTS,9(11):1049 2020(Nov.)
Author:Yumoto, Kentaro; Sato, Takashi; Nakashima, Kentaro; Namai, Fu; Shigemori, Suguru; Shimosato, Takeshi; Kaneko, Takeshi;
Keywords:heme oxygenase-1; Lactococcus lactis; emphysema; chronic obstructive pulmonary disease;


Oral priming with oligodeoxynucleotide particles from Lactobacillus rhamnosus GG attenuates symptoms of dextran sodium sulfate-induced acute colitis in mice
ANIMAL SCIENCE JOURNAL,91(1):e13468 2020(Oct.)
Author:Shigemori, Suguru; Namai, Fu; Ogita, Tasuku; Sato, Takashi; Shimosato, Takeshi;
Keywords:carbonate apatite-based particles; CpG-oligodeoxynucleotide; Lactobacillus rhamnosus GG; oral priming; probiotics;


Ribosome-Engineered Lacticaseibacillus rhamnosus Strain GG Exhibits Cell Surface Glyceraldehyde-3-Phosphate Dehydrogenase Accumulation and Enhanced Adhesion to Human Colonic Mucin
APPLIED AND ENVIRONMENTAL MICROBIOLOGY,86(20):e01448-20 2020(Oct.)
Author:Ishida, Minori; Namai, Fu; Shigemori, Suguru; Kajikawa, Shoko; Tsukagoshi, Masami; Sato, Takashi; Ogita, Tasuku; Shimosato, Takeshi;
Keywords:GAPDH; human colonic mucin; Lacticaseibacillus rhamnosus GG; ribosome engineering;


Construction of genetically modifiedLactococcus lactisthat produces bioactive anti-interleukin-4 single-chain fragment variable
MOLECULAR BIOLOGY REPORTS,47(9):7039-7047 2020(Sep.)
Author:Namai, Fu; Shigemori, Suguru; Ogita, Tasuku; Sato, Takashi; Shimosato, Takeshi;
Keywords:gmLAB; Lactococcus lactis; IL-4 scFv; Raw264; 7; Peritoneal macrophages; IL-4 signaling;


Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue
MOLECULAR BIOLOGY REPORTS,47(9):6717-6725 2020(Sep.)
Author:Mikami, Ayane; Ogita, Tasuku; Namai, Fu; Shigemori, Suguru; Sato, Takashi; Shimosato, Takeshi;
Keywords:Epididymal fat; Flavonifractor plautii; Lachnospiraceae; Obesity; Sphingobium; TNF-alpha;


Microbial therapeutics for acute colitis based on genetically modifiedLactococcus lactishypersecreting IL-1Ra in mice
EXPERIMENTAL AND MOLECULAR MEDICINE,52(9):1627-1636 2020(Sep.)
Author:Namai, Fu; Shigemori, Suguru; Ogita, Tasuku; Sato, Takashi; Shimosato, Takeshi;


Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS‐stimulated mouse macrophages
ANIMAL SCIENCE JOURNAL,91:e13436 2020(Aug. 05)
Author:Masami Tsukagoshi, Merisa Sirisopapong, Fu Namai, Minori Ishida, Supattra Okrathok, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Sutisa Khempaka, Takeshi Shimosato


乳酸菌組換え体を用いたバイオ医薬品の創製と課題
BIOINDUSTRY,37(5):53-59 2020(May 12)
Author:重盛 駿, 下里 剛士


Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice
FRONTIERS IN IMMUNOLOGY,11:379 2020(Feb. 28)
Author:Ogita, Tasuku; Yamamoto, Yoshinari; Mikami, Ayane; Shigemori, Suguru; Sato, Takashi; Shimosato, Takeshi;


Regulatory role of heme oxygenase-1 in silica-induced lung injury
RESPIRATORY RESEARCH,19:144 2018(Aug. 01)
Author:Kentaro Nakashima, Takashi Sato, Suguru Shigemori, Takeshi Shimosato, Masaharu Shinkai, Takeshi Kaneko


Recombinant Mouse Osteocalcin Secreted by Lactococcus lactis Promotes Glucagon-Like Peptide-1 Induction in STC-1 Cells
CURRENT MICROBIOLOGY,75(1):92-98 2018(Jan.)
Author:Fu Namai, Suguru Shigemori, Koichi Sudo, Takashi Sato, Yoshinari Yamamoto, Shireen Nigar, Tasuku Ogita, Takeshi Shimosato


Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
BMC IMMUNOLOGY,18:44 2017(Oct. 04)
Author:Shireen Nigar, Yoshinari Yamamoto, Takuma Okajima, Suguru Shigemori, Takashi Sato, Tasuku Ogita, Takeshi Shimosato


Genetically modified Lactococcus lactis producing a green fluorescent protein bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in lipopolysaccharide-stimulated RAW 264.7 cells
JOURNAL OF DAIRY SCIENCE,100(9):7007-7015 2017(Sep.)
Author:Suguru Shigemori, Fu Namai, Yoshinari Yamamoto, Nigar Shireen, Takashi Sato, Tasuku Ogita, Takeshi Shimosato


Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase
FRONTIERS IN IMMUNOLOGY,8:1049 2017(Aug. 30)
Author:Yoshinari Yamamoto, Ryu Sugimura, Takafumi Watanabe, Suguru Shigemori, Takuma Okajima, Shireen Nigar, Fu Namai, Takashi Sato, Tasuku Ogita, Takeshi Shimosato


Applications of Genetically Modified Immunobiotics with High Immunoregulatory Capacity for Treatment of Inflammatory Bowel Diseases
FRONTIERS IN IMMUNOLOGY,8:22 2017(Jan. 25)
Author:Suguru Shigemori, Takeshi Shimosato


Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,101(1):341-349 2017(Jan.)
Author:Suguru Shigemori, Masaki Ihara, Takashi Sato, Yoshinari Yamamoto, Shireen Nigar, Tasuku Ogita, Takeshi Shimosato


Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus
ANIMAL SCIENCE JOURNAL,87(5):710-717 2016(May)
Author:Yoshinari Yamamoto, Suguru Shigemori, Shireen Nigar, Kazushi Oshiro, Yeqin Wang, Takashi Sato, Takeshi Shimosato


Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice
MICROBIAL CELL FACTORIES,14:189 2015(Dec. 25)
Author:Suguru Shigemori, Takafumi Watanabe, Kai Kudoh, Masaki Ihara, Shireen Nigar, Yoshinari Yamamoto, Yoshihito Suda, Takashi Sato, Haruki Kitazawa, Takeshi Shimosato


Effect of Probiotics/Prebiotics on Cattle Health and Productivity
MICROBES AND ENVIRONMENTS,30(2):126-132 2015(May 23)
Author:Yutaka Uyeno, Suguru Shigemori, Takeshi Shimosato


Inhibitory/Suppressive Oligodeoxynucleotide Nanocapsules as Simple Oral Delivery Devices for Preventing Atopic Dermatitis in Mice
MOLECULAR THERAPY,23(2):297-309 2015(Feb.)
Author:Yeqin Wang, Yoshinari Yamamoto, Suguru Shigemori, Takafumi Watanabe, Kazushi Oshiro, Xinyu Wang, Pengfei Wang, Takashi Sato, Shinichi Yonekura, Sachi Tanaka, Haruki Kitazawa, Takeshi Shimosato


Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides from beta-Lactoglobulin Secreted by Lactococcus lactis
BIOMED RESEARCH INTERNATIONAL,2014:393598 2014(Aug. 03)
Author:Suguru Shigemori, Kazushi Oshiro, Pengfei Wang, Yoshinari Yamamoto, Yeqin Wang, Takashi Sato, Yutaka Uyeno, Takeshi Shimosato


Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,97(8):3603-3611 2013(Apr.)
Author:Suguru Shigemori, Shinichi Yonekura, Takashi Sato, Hajime Otani, Takeshi Shimosato


Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression
FEBS OPEN BIO,3(1):41-45 2013(Jan. 01)
Author:Yusuke Ito, Suguru Shigemori, Takashi Sato, Tomoyuki Shimazu, Konomi Hatano, Hajime Otani, Haruki Kitazawa, Takeshi Shimosato


Expression of a Biologically Active GFP-alpha(S1)-Casein Fusion Protein in Lactococcus lactis
CURRENT MICROBIOLOGY,64(6):569-575 2012(Jun.)
Author:Suguru Shigemori, Shinichi Yonekura, Takashi Sato, Maya Nakanishi, Hajime Otani, Takeshi Shimosato


Presentations
腸内常在性乳酸菌におけるイムノバイオティック機能の強化
酪農科学シンポジウム2021 2021(Sep. 24)
Presenter:金山 理佐, 生井 楓, 重盛 駿, 下里 剛士


Lacticaseibacillus rhamnosus GGが高脂肪飼料断続給餌マウスに与える影響
酪農科学シンポジウム2021 2021(Sep. 24)
Presenter:鳥居 創, 重盛 駿, 下里 剛士


ウォッシュタイプチーズにおける機能性成分の解析と免疫調節作用
日本畜産学会第129回大会 2021(Sep. 15)
Presenter:樋本 小春, 生井 楓, 重盛 駿, 荻田 佑, 下里 剛士


Limosilactobacillus ingluviei C37 from broiler inhibits inflammation in LPS-stimulated mouse macrophages
日本畜産学会第129回大会 2021(Sep. 15)
Presenter:塚越 まさ実, 生井 楓, 重盛 駿, 荻田 佑, 下里 剛士


Construction of genetically modified lactic acid bacteria producing anti-IL31Ra single-chain Fragment variable
日本畜産学会第129回大会 2021(Sep. 15)
Presenter:村上 愛斗, 生井 楓, 重盛 駿, 荻田 佑, 下里 剛士


乳酸菌組換え体の経口投与によるIL-1Ra 腸管送達能の検証
日本畜産学会第129回大会 2021(Sep. 15)
Presenter:生井 楓, 重盛 駿, 荻田 佑, 下里 剛士


乳酸菌組換え体が産生する抗インターロイキン4低分子抗体の生理活性評価
日本畜産学会第128回大会 2021(Mar. 29)
Presenter:生井 楓, 重盛 駿, 荻田 佑, 下里 剛士


抗PD-L1scFvを分泌する乳酸菌組換え体の構築
日本畜産学会第128回大会 2021(Mar. 29)
Presenter:村上 愛斗, 生井 楓, 重盛 駿, 荻田 佑, 下里 剛士


緑茶摂取によって増加するFlavonifractor plautiiの経口投与はIL-17の抑制を介して急性大腸炎からの回復を促進する
日本農芸化学会2021年度大会 2021(Mar. 20)
Presenter:三上 彩音, 荻田 佑, 重盛 駿, 下里 剛士


A breeding strategy of ribosome engineering for probiotics enhances the adhesion to human colonic mucin in Lacticaseibacillus rhamnosus GG
日本農芸化学会2021年度大会 2021(Mar. 20)
Presenter:Fu Namai, Suguru Shigemori, Takeshi Shimosato


大腸菌ミューテーター株を用いたマウス腸内における環境適応解析
第42回日本分子生物学会年 2019(Dec. 06)
Presenter:月見 友哉, 重盛 駿, 荒川 和晴, 増田 貴宏, 宮内 栄治, 中東 憲治, 冨田 勝, 大野 博司, 森 浩禎, 福田 真嗣


Construction of a genetically modified Lactococcus lactis producing single chain Fv against vascular endothelial growth factor
13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health 2019(Jun. 20)
Presenter:Masami Tsukagoshi, Fu Namai, Kohei Watanabe, Minako Iwai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato


Ribosome engineering enhances production of p40, a Lactobacillus rhamnosus GG-derived soluble protein, in S12 mutant strains
13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health 2019(Jun. 20)
Presenter:Shoko Kajikawa, Minori Ishida, Fu Namai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato


Oral administration of a genetically modified osteocalcin-secreting Lactococcus lactis improves carbohydrate metabolism in high-fat diet-induced obese mice
2019(Jun. 20)
Presenter:Fu Namai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato


Construction of genetically modified Lactococcus lactis secreting bioactive osteocalcin
World Dairy Summit 2017 2017(Nov. 01)
Presenter:Fu Namai, Suguru Shigemori, Tasuku Ogita, Takeshi Shimosato


Dose-comparison study of Lactococcus lactis producing heme oxygenase-1 for treatment of dextran sulfate sodium-induced acute colitis in mice
17th AAAP Animal Science Congress 2016(Aug. 25)
Presenter:Suguru Shigemori, Tasuku Ogita, Takeshi Shimosato


Construction of genetically modified Lactococcus lactis expressing buckwheat protein Fagag1 with strong allergenicity
2015 ADSA-ASAS Joint Annual Meeting 2015(Jul. 14)
Presenter:Suguru Shigemori, Yoshinari Yamamoto, Kazushi Oshiro, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato


Intracellular expression of cow’s milk allergens in genetically modified Lactococcus lactis
16th AAAP Animal Science Congress 2014(Nov. 12)
Presenter:Suguru Shigemori, Yoshinari Yamamoto, Pengfei Wang, Yeqin Wang,Takeshi Shimosato


Expression of immunoreactive αS1-casein in Lactococcus lactis as a treatment strategy for milk allergy
World Dairy Summit 2013 2013(Oct. 28)
Presenter:Suguru Shigemori, Hajime Otani, Takeshi Shimosato