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OHKANDA Junko

Academic OrganizationAcademic Assembly School of Science and Technology Institute of AgricultureTEL
Education and Research OrganizationFaculty of Agriculture Department of Agricultural and Life Sciences Division of Bioscience and BiotechnologyFAX
PositionProfessorMail Addressjohkanda@shinshu-u.ac.jp
Address8304, Minamiminowa-Village, Kamiina-County 399-4598Web sitehttp://www.shinshu-u.ac.jp/faculty/agriculture/lab/johkanda/index.html

Profile

Research Field
Bioorganic Chemistry
Chemical Biology
Keywords:protein-protein interactions , intrinsically disordered proteins and regions , Pharmaceutical and plant hormones , Antitumor agents , Signaling pathways , Posttranslational modification , Natural products , Peptides , 14-3-3 proteins
Current Subject
Design of synthetic molecules that regulate protein interactions
Keywords:mid-sized molecules
Academic Societies
Academic Societies
The Chemical Society of Japan
The Pharmaceutical Society of Japan
The Society of Synthetic Organic Chemistry, Japan
American Chemical Society
Academic Background
Graduate School
Ph. D., Tokyo University , 1996
M. Sc., Ochanomizu University , 1990
Awards
2017 , Nagase Foundation Research Award
Research Career
Research Career
2016- , Professor, Shinshu University
2013-2016 , Associate Professor, ICR, Kyoto University
2005-2013 , Associate Professor, ISIR, Osaka University
2004-2005 , Lecturer, Tokyo Gakugei University
2003-2003 , Researcher, Achillion Pharmaceuticals, Inc. (Connecticut, USA)
1998-2003 , Postdoctral Associate, Department of Chemistry, Yale University
1991-1997 , Assistant Professor, Seikei University
1990-1991 , Researcher, Ricoh Co. Ltd.

Other Career
2017- , Bioorganic Chemistry Editorial board member (Elsevier)

Research

Books, Articles, etc.
Books
Chemical approach toward controlling of transient protein interactions, Chemical approach toward controlling of transient protein interactions, published in Middle Molecular Strategy, 77-96
Springer, Singapore 2021(Jul. 14)
Author:Junko Ohkanda


Self-Assembled Receptors for Protein Surface Recognition, Self-assembled receptors for protein surface recognition, published in Comprehensive Supramolecular Chemistry II, 351-369
Elsevier, Oxford 2017
Author:Junko Ohkanda


Articles
Design, synthesis, and functional evaluation of triazine-based bivalent agents that simultaneously target the active site and hot spot of phosphatase Cdc25B
Bioorg. Med. Chem. Lett.,in press. 2021(Jul. 12)
Author:Yosei Nagaoka, Prakash Parvatkar, Go Hirai, Junko Ohkanda


Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
MOLECULES,26(8) 2021(Apr.)
Author:Hosoya, Yusuke; Ohkanda, Junko;
Keywords:intrinsically disordered proteins; protein– protein interactions; liquid– liquid phase separation; drug discovery;


Fusicoccin: A Chemical Modulator for 14-3-3 Proteins
CHEMISTRY LETTERS,50(1):57-67 2021(Jan.)
Author:Ohkanda, Junko;
Keywords:Stabilizers and inhibitors; Protein-protein interactions; Antitumor agents;


Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors
Chemical Communications,56:11203-11206 2020(Aug. 21)
Author:Yusuke Hosoya, Wataru Nojo, Isao Kii, Takanori Suzuki, Miki Imanishi, Junko Ohkanda


A NOVEL CONDENSED HETEROCYCLIC QUINONE WITH A DIBENZOFURANOBISTHIADIAZOLE SKELETON
HETEROCYCLES,101(1):99-103 2020
Author:Sugawara, Kazuma; Nojo, Wataru; Ishigaki, Yusuke; Ohkanda, Junko; Suzuki, Takanori;
Keywords:Quinone; Intermolecular Interaction; Oxidation; Condensation; Charge-Transfer;


Copper-Free Huisgen Cycloaddition for the 14-3-3-Templated Synthesis of Fusicoccin-Peptide Conjugates
CHEMISTRY-AN ASIAN JOURNAL,15:742-747 2020
Author:Masuda, Ryoma; Kawasaki, Yuuya; Igawa, Kazunobu; Manabe, Yoshiyuki; Fujii, Hiroshi; Kato, Nobuo; Tomooka, Katsuhiko; Ohkanda, Junko;


Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine
BIOCONJUGATE CHEMISTRY,30(2):454-460 2019(Feb.)
Author:Kawaguchi, Yoshimasa; Ise, Shoko; Azuma, Yusuke; Takeuchi, Toshihide; Kawano, Kenichi; Toan Khanh Le; Ohkanda, Junko; Futaki, Shiroh;


A Guanidyl-Based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-Raf
CHEMISTRY-A EUROPEAN JOURNAL,25(59):13531-13536 2019
Author:Tsubamoto, Mai; Toan Khanh Le; Li, Minghua; Watanabe, Taku; Matsumi, Chiemi; Parvatkar, Prakash; Fujii, Hiroshi; Kato, Nobuo; Sun, Jiazhi; Ohkanda, Junko;


Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity
CHEMISTRY-A EUROPEAN JOURNAL,24(60):16066-16071 2018
Author:Ohkanda, Junko; Kusumoto, Atsushi; Punzalan, Louvy; Masuda, Ryoma; Wang, Chenyu; Parvatkar, Prakash; Akase, Dai; Aida, Misako; Uesugi, Motonari; Higuchi, Yusuke; Kato, Nobuo;


A Strategy of Designing Mid-sized Synthetic Molecules that Recognize Interfaces of Protein protein Interactions
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN,75(7):735-745 2017(Jul.)
Author:Ohkanda, Junko;


たんぱく質間相互作用を制御する合成分子の創製
京都大学化学研究所スーパーコンピュータシステム研究成果報告書,2016:7-7 2017(Mar.)
Author:大神田 淳子;


Protein-guided self-assembly for controlling protein-protein interactions
Journal of the Society of Japanese Women Scientists,17:1-7 2017
Author:Junko Ohkanda


Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,137(50):15624-15627 2015
Author:Parvatkar, Prakash; Kato, Nobuo; Uesugi, Motonari; Sato, Shin-ichi; Ohkanda, Junko;*


RNA-Directed Amino Acid Coupling as a Model Reaction for Primitive Coded Translation
CHEMBIOCHEM,15(6):794-798 2014
Author:Harada, Kazuo*; Aoyama, Shoko; Matsugami, Akimasa; Kumar, Penmetcha K. R.; Katahira, Masato; Kato, Nobuo; Ohkanda, Junko;


Module Assembly for Designing Multivalent Mid-Sized Inhibitors of Protein-Protein Interactions
CHEMICAL RECORD,13(6):561-575 2013(Dec.)
Author:Ohkanda, Junko;*


Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers
ACS CHEMICAL BIOLOGY,8(9):1869-1875 2013(Sep.)
Author:Molzan, Manuela; Kasper, Stefan; Roeglin, Lars; Skwarczynska, Malgorzata; Sassa, Takeshi; Inoue, Takatsugu; Breitenbuecher, Frank; Ohkanda, Junko; Kato, Nobuo; Schuler, Martin; Ottmann, Christian;


Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein
MOLECULAR BIOSYSTEMS,9(5):940-943 2013
Author:Maki, Toshio; Kawamura, Akie; Kato, Nobuo; Ohkanda, Junko;*


Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase
CHEMICAL COMMUNICATIONS,49(49):5535-5537 2013
Author:Hayashi, Daisuke; Kato, Nobuo; Kuzuyama, Tomohisa; Sato, Yasuo; Ohkanda, Junko;*


A Semisynthetic Fusicoccane Stabilizes a Protein-Protein Interaction and Enhances the Expression of K+ Channels at the Cell Surface
CHEMISTRY & BIOLOGY,20(4):583-593 2013
Author:Anders, Carolin; Higuchi, Yusuke; Koschinsky, Kristin; Bartel, Maria; Schumacher, Benjamin; Thiel, Philipp; Nitta, Hajime; Preisig-Mueller, Regina; Schlichthoerl, Guenter; Renigunta, Vijay; Ohkanda, Junko; Daut, Juergen; Kato, Nobuo; Ottmann, Christian;


Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors
BIOORGANIC & MEDICINAL CHEMISTRY,21(14):4004-4010 2013
Author:Machida, Shinnosuke; Tsubamoto, Mai; Kato, Nobuo; Harada, Kazuo; Ohkanda, Junko;


A Novel Fusicoccin Derivative Preferentially Targets Hypoxic Tumor Cells and Inhibits Tumor Growth in Xenografts
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY,12(7):791-800 2012(Sep.)
Author:Kawakami, Koshi; Hattori, Miho; Inoue, Takatsugu; Maruyama, Yuriko; Ohkanda, Junko; Kato, Nobuo; Tongu, Miki; Yamada, Takaya; Akimoto, Miho; Takenaga, Keizo; Sassa, Takeshi; Suzumiy, Junji; Honma, Yoshio;


Phosphopeptide-Dependent Labeling of 14-3-3 zeta Proteins by Fusicoccin-Based Fluorescent Probes
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,51(2):509-512 2012
Author:Takahashi, Michiko; Kawamura, Akie; Kato, Nobuo; Nishi, Tsuyoshi; Hamachi, Itaru; Ohkanda, Junko;*


Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for alpha-chymotrypsin and cytochrome c
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(6):2354-2358 2012
Author:Yamaguchi, Yoshinobu; Kato, Nobuo; Azuma, Hideki; Nagasaki, Takeshi; Ohkanda, Junko;*


Bivalent Inhibitors for Disrupting Protein Surface-Substrate Interactions and for Dual Inhibition of Protein Prenyltransferases
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,133(4):958-963 2011
Author:Machida, Shinnosuke; Kato, Nobuo; Harada, Kazuo; Ohkanda, Junko;*


Protein surface recognition by dendritic ruthenium(II) tris(bipyridine) complexes
CHEMICAL COMMUNICATIONS,(45):6949-6951 2009
Author:Ohkanda, Junko; Satoh, Ritsuko; Kato, Nobuo;


Structurally Simple Inhibitors of Lanosterol 14 alpha-Demethylase Are Efficacious In a Rodent Model of Acute Chagas Disease
JOURNAL OF MEDICINAL CHEMISTRY,52(12):3703-3715 2009
Author:Suryadevara, Praveen Kumar; Olepu, Srinivas; Lockman, Jeffrey W.; Ohkanda, Junko; Karimi, Mandana; Verlinde, Christophe L. M. J.; Kraus, James M.; Schoepe, Jan; Van Voorhis, Wesley C.; Hamilton, Andrew D.; Buckner, Frederick S.; Gelb, Michael H.;


Transannular Proton Transfer in the Cyclization of Geranylgeranyl Diphosphate to Fusicoccadiene, a Biosynthetic Intermediate of Fusicoccins
ORGANIC LETTERS,11(14):3044-3047 2009
Author:Toyomasu, Tomonobu; Tsukahara, Mai; Kenmoku, Hiromichi; Anada, Masahide; Nitta, Hajime; Ohkanda, Junko; Mitsuhashi, Wataru; Sassa, Takeshi; Kato, Nobuo;


Design and functional evaluation of dual prenyltransferase inhibitors for simultaneous recognition of active site and exterior protein surface
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,238 2009
Author:Machida, Shinnosuke; Kato, Nobuo; Harada, Kazuo; Ohkanda, Junko;


Module assembly for protein-surface recognition: Geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces
CHEMISTRY-A EUROPEAN JOURNAL,14(5):1392-1401 2008
Author:Machida, Shinnosuke; Usuba, Kakeru; Blaskovich, Michelle A.; Yano, Akiko; Harada, Kazuo; Sebti, Said M.; Kato, Nobuo; Ohkanda, Junko;


Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter
ONCOGENE,26(5):633-640 2007(Feb.)
Author:Delarue, F. L.; Adnane, J.; Joshi, B.; Blaskovich, M. A.; Wang, D-A; Hawker, J.; Bizouarn, F.; Ohkanda, J.; Zhu, K.; Hamilton, A. D.; Chellappan, S.; Sebti, S. M.;


ORGN 129-Bivalent inhibitors of Type-I geranylgeranyltransferase for simultaneous recognition of interior and exterior protein surfaces
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,234 2007
Author:Ohkanda, Junko; Machida, Shinnosuke; Kato, Nobuo; Blaskovich, Michelle A.; Sebti, Saied M.; Harada, Kazuo;


Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase
ORGANIC & BIOMOLECULAR CHEMISTRY,4(3):482-492 2006
Author:Ohkanda, J; Strickland, CL; Blaskovich, MA; Carrico, D; Lockman, JW; Vogt, A; Bucher, CJ; Sun, JZ; Qian, YM; Knowles, D; Pusateri, EE; Sebti, SM; Hamilton, AD;


Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents
JOURNAL OF MEDICINAL CHEMISTRY,47(2):432-445 2004
Author:Ohkanda, J; Buckner, FS; Lockman, JW; Yokoyama, K; Carrico, D; Eastman, R; de Luca-Fradley, K; Davies, W; Croft, SL; Van Voorhis, WC; Gelb, MH; Sebti, SM; Hamilton, AD;


In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability
BIOORGANIC & MEDICINAL CHEMISTRY,12(24):6517-6526 2004
Author:Carrico, D; Ohkanda, J; Kendrick, H; Yokoyama, K; Blaskovich, MA; Bucher, CJ; Buckner, FS; Van Voorhis, WC; Chakrabarti, D; Croft, SL; Gelb, MH; Sebti, SM; Hamilton, AD;


In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus
JOURNAL OF CLINICAL INVESTIGATION,112(3):407-414 2003(Aug.)
Author:Bordier, BB; Ohkanda, J; Liu, P; Lee, SY; Salazar, FH; Marion, PL; Ohashi, K; Meuse, L; Kay, MA; Casey, JL; Sebti, SM; Hamilton, AD; Glenn, JS;


The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells
LEUKEMIA,17(2):451-457 2003(Feb.)
Author:Bolick, SCE; Landowski, TH; Boulware, D; Oshiro, MM; Ohkanda, J; Hamilton, AD; Sebti, SM; Dalton, WS;


A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,100(25):15149-15153 2003
Author:Buckner, F; Yokoyama, K; Lockman, J; Aikenhead, K; Ohkanda, J; Sadilek, M; Sebti, S; Van Voorhis, W; Hamilton, A; Gelb, MH;


Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice
CANCER RESEARCH,63(24):8922-8929 2003
Author:Sun, JZ; Ohkanda, J; Coppola, D; Yin, H; Kothare, M; Busciglio, B; Hamilton, AD; Sebti, SM;


The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status
CELL DEATH AND DIFFERENTIATION,9(7):702-709 2002(Jul.)
Author:Crespo, NC; Delarue, F; Ohkanda, J; Carrico, D; Hamilton, AD; Sebti, SM;


CAAX peptidomimetics: Their farnesyltransferase inhibition activity and antitumor effect
SEIKAGAKU,74(1):46-50 2002(Jan.)
Author:Ohkanda, J;


Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold
JOURNAL OF MEDICINAL CHEMISTRY,45(1):177-188 2002
Author:Ohkanda, J; Lockman, JW; Kothare, MA; Qian, YM; Blaskovich, MA; Sebti, SM; Hamilton, AD;


Prenyltransferase inhibitors as antitumor and antiparasitic agents: Rational design based on CAAX peptide and solution phase combinatorial approaches.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,224:U30-U30 2002
Author:Ohkanda, J; Lockman, JW; Carrico, D; Strickland, CL; Sebti, SM; Gelb, MH; Hamilton, AD;


Design, synthesis and evaluation of peptidomimetic farnesyltransferase inhibitor ester pro-drugs as potent antiparasitic agents.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,224:U28-U28 2002
Author:Carrico, D; Ohkanda, J; Gelb, MH; Blaskovich, MA; Sebti, SM; Hamilton, AD;


Toward Chagas disease chemotherapeutics: Development of simple compounds active against Trypanosoma cruzi.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,224:U17-U17 2002
Author:Lockman, JW; Ohkanda, J; Yokoyama, K; Eastman, RT; Buckner, FS; Gelb, MH; Hamilton, AD;


Synthesis of linear and cyclic hexapeptides with N epsilon-(1,2-dihydro-1-hydroxy-2-oxopyrimidin-4-yl)-L-lysyl-beta-alanyl as the repeating unit and properties of their iron(III) complexes
HETEROCYCLES,58:371-381 2002
Author:Katoh, A; Inoue, Y; Nagashima, H; Hikita, Y; Ohkanda, J; Saito, R;


Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,11(6):761-764 2001
Author:Ohkanda, J; Lockman, JW; Yokoyama, K; Gelb, MH; Croft, SL; Kendrick, H; Harrell, MI; Feagin, JE; Blaskovich, MA; Sebti, SM; Hamilton, AD;


The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells
JOURNAL OF BIOLOGICAL CHEMISTRY,276(19):16161-16167 2001
Author:Crespo, NC; Ohkanda, J; Yen, TJ; Hamilton, AD; Sebti, SM;


3-hydroxy-4(1H)-pyridinone-containing linear and cyclic hexapeptides and their iron(III) complexes - Synthesis, property, and the growth-promotion activity-
HETEROCYCLES,55(11):2171-2187 2001
Author:Katoh, A; Hikita, Y; Harata, M; Ohkanda, J; Tsubomura, T; Higuchi, A; Saito, R; Harada, K;


Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
CARCINOGENESIS,21(1):113-116 2000(Jan.)
Author:Lantry, LE; Zhang, ZQ; Yao, RS; Crist, KA; Wang, Y; Ohkanda, J; Hamilton, AD; Sebti, SM; Lubet, RA; You, M;


Synthesis of quinoxaline derivatives bearing the styryl and phenylethynyl groups and application to a fluorescence derivatization reagent
HETEROCYCLES,52(2):911-920 2000
Author:Katoh, A; Yoshida, T; Ohkanda, J;


Inhibition of farnesyltransferase increases TGF beta type II receptor expression and enhances the responsiveness of human cancer cells to TGF beta
ONCOGENE,19(48):5525-5533 2000
Author:Adnane, J; Bizouarn, FA; Chen, Z; Ohkanda, J; Hamilton, AD; Munoz-Antonia, T; Sebti, SM;


Development of a tripeptide mimetic strategy for the inhibition of protein farnesyltransferase
TETRAHEDRON,56(50):9833-9841 2000
Author:Kothare, MA; Ohkanda, J; Lockman, JW; Qian, YM; Blaskovich, MA; Sebti, SM; Hamilton, AD;


Synthesis of 6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline and application to a new fluorescence derivatization reagent of fatty acids for the high-performance liquid chromatographic analysis
HETEROCYCLES,50(1):299-308 1999
Author:Katoh, A; Fujimoto, T; Takahashi, M; Ohkanda, J;


Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I
JOURNAL OF MEDICINAL CHEMISTRY,42(8):1333-1340 1999
Author:Vasudevan, A; Qian, YM; Vogt, A; Blaskovich, MA; Ohkanda, J; Sebti, SM; Hamilton, AD;


Novel nonthiol inhibitors of farnesyl transferase show potent antitumor properties.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,218:U984-U984 1999
Author:Ohkanda, J; Blaskovich, M; Sun, J; Sebti, SM; Hamilton, AD;


Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine
CANCER RESEARCH,59(19):4919-4926 1999
Author:Sun, JZ; Blaskovich, MA; Knowles, D; Qian, YM; Ohkanda, J; Bailey, RD; Hamilton, AD; Sebti, SM;


N-hydroxyamide-containing heterocycles: Synthesis, reactivities, and iron(III)-chelating properties
REVIEWS ON HETEROATOM CHEMISTRY,18:87-118 1998
Author:Ohkanda, J; Katoh, A;


N-hydroxypyrazinone-bearing homotrioxacalix[3]arene: its cooperative molecular recognition by metal complexation
CHEMICAL COMMUNICATIONS,(3):375-376 1998
Author:Ohkanda, J; Shibui, H; Katoh, A;


Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,252(1):111-116 1998
Author:Kucich, U; Rosenbloom, JC; Shen, G; Abrams, WR; Blaskovich, MA; Hamilton, AD; Ohkanda, J; Sebti, SM; Rosenbloom, J;


New hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, alpha,omega-diamine and 1,1,1-tris(carboxyethoxymethyl)-ethane or tri(carboxybutyl)isocyanurate. Synthesis and characterization of their iron(III) complexes
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS,(22):3859-3864 1998
Author:Katoh, A; Hida, Y; Kamitani, J; Ohkanda, J;


Synthesis of 2,2 '-bipyridines bearing amino or carboxyl group at the side chain and physical properties of their ruthenium(II) complexes
HETEROCYCLES,49:281-296 1998
Author:Katoh, A; Kitamura, Y; Fujii, H; Horie, Y; Satoh, T; Ohkanda, J; Yokomori, Y;


Functionalized N-hydroxyamide-containing heterocycles - Synthesis, reaction, and metal-chelating property
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN,55(6):524-534 1997(Jun.)
Author:Ohkanda, J; Katoh, A;


Structural analysis of N-(omega-phenylalkyl)substituted quinoxalin-2(1H)-ones and -thiones
HETEROCYCLES,44:357-366 1997
Author:Katoh, A; Yoshida, T; Ohkanda, J; Nishio, T;


Novel iron sequestering agents: Synthesis and iron-chelating properties of hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, omega-amino carboxylic acid, and tris(2-aminoethyl)amine
JOURNAL OF ORGANIC CHEMISTRY,62(11):3618-3624 1997
Author:Ohkanda, J; Kamitani, J; Tokumitsu, T; Hida, Y; Konakahara, T; Katoh, A;


Synthesis of 1,3-linked 1,4-dihydropyridines containing the L-tyrosine residue and the influence of their structures upon the enantioselective reduction
HETEROCYCLES,45(8):1441-1446 1997
Author:Katoh, A; Naruse, S; Ohkanda, J; Yamamoto, H;


N-hydroxyamide-containing heterocycles .6. Application of 1-hydroxy-4,6-dimethyl-2(1H)-pyrimidinone to a new benzyloxycarbonylating agent
HETEROCYCLIC COMMUNICATIONS,2(2):141-144 1996
Author:Katoh, A; Kondoh, S; Ohkanda, J;


The influence of the chirality of synthetic iron chelators bearing N-hydroxy-2(1H)-pyrazinones and amino acid residues upon iron removal from human transferrin
CHEMISTRY LETTERS,(6):423-424 1996
Author:Ohkanda, J; Katoh, A;


Synthesis of 2,3-disubstituted 6-aminoquinoxalines and their application to new fluorescence derivatization reagents for carboxylic acids
CHEMISTRY LETTERS,(5):369-370 1996
Author:Katoh, A; Takahashi, M; Ohkanda, J;


Synthesis of novel amphiphilic compounds containing aza-12-crown-4 or D-glucosamine and their ion permeability
HETEROCYCLES,43(3):589-599 1996
Author:Katoh, A; Ishida, S; Ohkanda, J; Washizu, M;


N-hydroxyamide-containing heterocycles .7. Preparation and photochemical behavior of 1-benzyloxy-2(1H)-pyrazinones
HETEROCYCLES,43(4):883-889 1996
Author:Ohkanda, J; Kumasaka, T; Takasu, A; Hasegawa, T; Katoh, A;


N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .4. SYNTHESIS AND FE-III-CHELATING PROPERTIES OF NOVEL HEXADENTATE LIGANDS COMPOSED OF N-HYDROXY-2(1H)-PYRAZINONE, AMINO-ACID-RESIDUES, AND TRIS(2-AMINOETHYL)AMINE
JOURNAL OF ORGANIC CHEMISTRY,60(6):1583-1589 1995
Author:OHKANDA, J; KATOH, A;


N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .5. SYNTHESIS OF NOVEL HEXADENTATE LIGANDS COMPOSED OF N-HYDROXY-2(1H)-PYRAZINONE, ALIPHATIC DIAMINE, AND 1,1,1-TRIS(CARBOXYETHOXYMETHYL)ETHANE, AND PROPERTIES OF THEIR FERRIC COMPLEXES
TETRAHEDRON,51(47):12995-13002 1995
Author:OHKANDA, J; KATOH, A;


SYNTHESIS OF 2(1H)-PYRIMIDINONE-CONTAINING ALPHA-AMINO-ACID DERIVATIVES BY CHEMICAL MODIFICATION OF L-GLUTAMIC ACID
CHEMICAL & PHARMACEUTICAL BULLETIN,42(7):1514-1517 1994(Jul.)
Author:KATOH, A; INOKAWA, M; OHKANDA, J; MITSUHASHI, K;


N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .3. THE RING TRANSFORMATION OF 1-BENZYLOXY-2(1H)-PYRIMIDINONES INTO 2-ISOXAZOLINES WITH HYDROXYLAMINE
HETEROCYCLES,37(2):1141-1146 1994
Author:KATOH, A; OHKANDA, J; TAMURA, A; YOSHIIKE, Y; MITSUHASHI, K;


N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .2. SYNTHESIS AND IRON(III) COMPLEX-FORMING TENDENCY OF 1-HYDROXY-2(1H)-PYRIMIDINONE AND 1-HYDROXY-2(1H)-PYRAZINONE
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN,66(3):841-847 1993(Mar.)
Author:OHKANDA, J; TOKUMITSU, T; MITSUHASHI, K; KATOH, A;


A CONVENIENT SYNTHESIS OF 3-(ARYL)SUBSTITUTED 2,4(1H,3H)-PTERIDINEDIONES AND THEIR ABSORPTION AND FLUORESCENCE SPECTROSCOPIC CHARACTERISTICS
HETEROCYCLES,35(2):949-954 1993
Author:KATOH, A; OHKANDA, J; SATO, H; SAKAMOTO, T; MITSUHASHI, K;


N-HYDROXYAMIDE-CONTAINING HETEROCYCLES - NEW EFFECTIVE ADDITIVES FOR PEPTIDE-SYNTHESIS BY THE DICYCLOHEXYLCARBODIIMIDE METHOD
CHEMISTRY LETTERS,(10):2009-2012 1992(Oct.)
Author:KATOH, A; OHKANDA, J; ITOH, Y; MITSUHASHI, K;


STRUCTURAL ASPECTS OF THE MECHANICAL AND THERMAL-DISSOCIATION OF THE CENTRAL BOND IN 2,2'-BIS(2,3,4-TRIARYLCHROMENYL)S
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2,(1):59-63 1992(Jan.)
Author:OHKANDA, J; MORI, Y; MAEDA, K; OSAWA, E;


UNUSUAL SUBSTITUENT EFFECT BY THE ALPHA-ACETYL GROUP ON THE TYPE-II PHOTOREACTION OF VALEROPHENONES - STRONG WAVELENGTH DEPENDENCE OF QUANTUM YIELDS
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,64(3):299-306 1992
Author:HASEGAWA, T; OHKANDA, J; KOBAYASHI, M; YOSHIOKA, M;


ISOLATION OF THE INTERMEDIATES AND IMPROVED SYNTHESIS OF PYRIDO[1',2'/1,2]IMIDAZOL[4,5-B]PYRAZINES AND PYRIDO[1',2'/1,2]IMIDAZOL]4,5-B]QUINOXALINES
HETEROCYCLES,34(10):1965-1972 1992
Author:KATOH, A; UEDA, SH; OHKANDA, J; HIROTA, M; KOMINE, H; MITSUHASHI, K;