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KOHSAKA Yasuhiro

Academic OrganizationAcademic Assembly School of Science and Technology Institute of Textile Science and TechnologyTEL0268-21-5488
Education and Research OrganizationInterdisciplinary Cluster for Cutting Edge Research Research Initiative for Supra-MaterialsFAX
PositionAssociate ProfessorMail Addresskohsaka@shinshu-u.ac.jp
Address3-15-1, Tokida, Ueda City 386-8567Web sitehttp://fiber.shinshu-u.ac.jp/kohsaka/index_e.html

Profile

Assigned Class
Faculty of Textile Science and Technology Department of Chemistry and Materials Course of Functional Polymer Science
Research Group
Kohsaka Laboratory
Research Field
Polymer Synthesis
Keywords:Precise polymerization chemistry , Functional monomer , Anionic polymerization , Ring-opening polymerization (ROP) , Radical polymerization , Stimuli-responsive materials , End-functionalization , Stereoregular polymer , Click chemistry
Academic Background
Graduate School
Tokyo Institute of Technology , (Department of Organic and Polymeric Materials) , 2011
Tokyo Institute of Technology , (Department of Organic and Polymeric Materials) , 2008

College
Tokyo Institute of Technology , (Faculty of Engineering) , 2006

Degree
Doctor of Engineering , Tokyo Institute of Technology
Awards
2018
2018 , Emerging Investigator 2018 , This is not a prize but honor
2015
2009
Research Career
Research Career
2011-2015 , Assistant ProfessorGraduate School of Engineering Science, Osaka University
2008-2011

Overseas Education
2009-2010 , Massachusetts Institute of Technology

Research

Books, Articles, etc.
Books
「クリックケミストリー ―基礎から実用まで―」 第15章 クリック反応性基を有するアクリル系ポリマーの精密合成と反応
シーエムシー出版 2014
Author:高坂泰弘,北浦健大,北山辰樹


Polyrtaxane Networks as a topologically cross-linked polymer: Synthesis and properties in Supramolecular Polymer Chemistry
Willey-VCH 2012
Author:Yasuhito Koyama, Takayuki Arai, Yasuhiro Kohsaka, Masahiro Shioya, Toshikazu Takata


Articles
Controls and Effects of Monomer Junctions and Sequences in Curable and Degradable Polyarylate Containing Acrylate Moieties
Macromol. Rapid Commun. 2021
Author:Y. Kohsaka, N. Nagai


Magnesium bromide (MgBr2) as a catalyst for living cationic polymerization and ring-expansion cationic polymerization"
Polym. Chem 2021
Author:Y. Daito, R. Kojima, N. Kusuyama, Y. Kohsaka, M. Ouchi


Synthesis of Poly(Conjugated Ester)s by Ring-Opening Polymerization of Cyclic Hemiacetal Ester Bearing Acryl Skeleton
European Polymer Journal,120:109185 2020
Author:Yasuhiro Kohsaka, Mai Yamashita, Yosuke Matsuhashi, Shuji Yamashita


End-reactive poly(tetrahydrofuran) for functionalization and graft copolymer synthesis via a conjugate substitution reaction
Polymer Journal,52:75 2020
Author:Yasuhiro Kohsaka, Naoki Nagatsuka


Divergence of polycondensation by a tandem reaction based on sequential conjugate substitutions
Polymer Chemistry,:5128 2020
Author:Keito Hagiwara, Yasuhiro Kohsaka


Degradable and curable poly(conjugated ester)s prepared by acryl- and conjugate-substitutions of the ‘smallest’ monomer
European Polymer Journal,141:110049 2020
Author:Yasuhiro Kohsaka, Koki Nagai


(FOCUS REVIEW) Conjugate substitution reaction of α-(substituted methyl)acrylates in polymer chemistry
Polymer Journal,52:1175 2020
Author:Yasuhiro Kohsaka


Degradable and curable poly(conjugated ester)s prepared by acryl- and conjugate-substitutions of the ‘smallest’ monomer
Eur. Polym. J.,141:110049 2020
Author:Y. Kohsaka, K. Nagai,


Radical Polymerization of ‘Dehydroaspirin’ with a Formation of Hemiacetal Ester Skeleton: A Hint for Recyclable Vinyl Polymers
Polymer Chemistry,10:2764 2019
Author:Akane Kazama, Yasuhiro Kohsaka


Synthesis and properties of polyethers containing 1,3-butadiene skeleton in the backbones
Chemistry Letters,48(8):894 2019
Author:Yasuhiro Kohsaka, Akira HIramatsu


Esterification with Aromatic Acyl-1,2,4-triazole Catalyzed by Weak Base at the Rate Comparable to Acyl Chloride
CHEMISTRY LETTERS,47(1):100-102 2018
Author:Kohsaka, Yasuhiro; Homma, Kazumasa; Sugiyama, Susumu; Kimura, Yoshikazu;


Bifunctional Acyl-1,2,4-triazole: An Alternative Monomer of Dicarbonyl Chloride for Metal- and Halogen-free Polyester Synthesis
CHEMISTRY LETTERS,47(2):221-224 2018
Author:Kohsaka, Yasuhiro; Homma, Kazumasa; Mori, Ichiro; Sugiyama, Susumu; Kimura, Yoshikazu;


(INVITED) Conjugate substitution and addition of alpha-substituted acrylate: a highly efficient, facile, convenient, and versatile approach to fabricate degradable polymers by dynamic covalent chemistry
POLYMER CHEMISTRY,9(13):1610-1617 2018
Author:Kohsaka, Yasuhiro; Miyazaki, Takumi; Hagiwara, Keito;


(総説)高機能ポリマー原料としてのジカルボン酸クロリドと類縁体
マテリアルステージ,18(7):38-47 2018
Author:高坂泰弘,木村芳一


(総説)α-機能化アクリル酸エステルの精密設計による機能高分子合成
機能材料,38(9):45-53 2018
Author:高坂泰弘


(総説)アクリル酸エステル誘導体の共役置換反応を利用した機能高分子合成
日本ゴム協会誌,91(11) 2018
Author:高坂泰弘


Synthesis of isotactic poly[alpha-(hydroxymethyl)acrylate] by anionic polymerization of the protected monomer
POLYMER BULLETIN,74(5):1935-1948 2017(May)
Author:Kohsaka, Yasuhiro; Yamamoto, Kazuki; Suzawa, Kazuha; Kitayama, Tatsuki;


Synthesis and reaction of block copolymer composed of independently clickable segments via monomer-selective living copolymerization
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS,23(5):1133-1140 2017(May)
Author:Ladelta, Viko; Kohsaka, Yasuhiro; Kitayama, Tatsuki;


Polymerization of α-(Halomethyl)acrylates through Sequential Nucleophilic Attack of Dithiols using a Combination of Addition–Elimination and Click Reactions
Polym. Chem.,8:976-979 2017
Author:Yasuhiro Kohsaka, Keito Hagiwara, Keiichiro Ito


Polymerization of alpha-(halomethyl)acrylates through sequential nucleophilic attack of dithiols using a combination of addition-elimination and click reactions
POLYMER CHEMISTRY,8(6):976-979 2017
Author:Kohsaka, Yasuhiro; Hagiwara, Keito; Ito, Keiichiro;


Anionic polymerization of ethyl acrylate initiated by tetrabutylammonium azide: direct synthesis of end-clickable polyacrylate
POLYMER CHEMISTRY,8(26):3858-3861 2017
Author:Kataoka, Yuki; Kohsaka, Yasuhiro; Kitaura, Takehiro; Domae, Shogo; Ishihara, Shoya; Kitayama, Tatsuki;


Acid- or photo-cleavable polyrotaxane: Subdivision of supramolecular main-chain type polyrotaxane structure induced by acidolysis or photolysis
POLYMER,125:134-137 2017
Author:Araki, Jun; Honda, Yuta; Kohsaka, Yasuhiro;


α-Exomethylene lactone possessing acetal–ester linkage: Polymerization and postpolymerization modification for water-soluble polymer
Journal of Polymer Science Part A: Polymer Chemistry,54(7):955-961 2016
Author:Kohsaka, Y; Matsumoto, Y; Zhang, T; Matsuhashi, Y; Kitayama, T


Synthesis of thermo-responsive polymer via radical (co)polymerization of N,N-dimethyl-α-(hydroxymethyl)acrylamide with N,N-diethylacrylamide
Polymers,8:374 2016
Author:Yasuhiro Kohsaka, Yoshiaki Tanimoto


(総説)α-機能化アクリル酸エステルの重合化学 —精密重合・機能創成を目指した分子設計—
高分子論文集,73(5):412-427 2016
Author:髙坂泰弘


Synthesis and post-polymerization reaction of end-clickable stereoregular polymethacrylates via termination of stereospecific living anionic polymerization
POLYMER CHEMISTRY,6(7):1078-1087 2015
Author:Kohsaka, Yasuhiro; Kurata, Takashi; Yamamoto, Kazuki; Ishihara, Shoya; Kitayama, Tatsuki;


Stereospecific Anionic Polymerization of α-(Hydroxymethyl)acrylate with Protective Group
Macromol. Symp.,350:86-98 2015
Author:Yasuhiro Kohsaka, Kazuha Suzawa, Tatsuki Kitayama


C60-Containing polymethacrylates: synthesis, properties, and potential application as n-type semiconductor for organic solar cell
Polym. Bull.,72:1265-1280 2015
Author:Viko Ladelta, Yasuhiro Kohsaka, Toshihiro Ohnishi, Michio Matsumura, Tatsuki Kitayama


Stereoregular poly(methyl methacrylate) with double-clickable omega-end: synthesis and click reaction
POLYMER CHEMISTRY,6(19):3601-3607 2015
Author:Kohsaka, Yasuhiro; Yamamoto, Kazuki; Kitayama, Tatsuki;


Termination of living anionic polymerization of butyl acrylate with α-(chloromethyl)acrylate for end-functionalization and application to the evaluation of monomer reactivity
Macromol. Chem. Phys.,216(14):1534-1539 2015
Author:Yasuhiro Kohsaka, Shoya Ishihara, Tatsuki Kitayama


α-(Aminomethyl)acrylate: Polymerization and spontaneous post-polymerization modification of β-amino acid ester for pH- / temperature-responsive material
Polym. Chem.,6:5026-5029 2015
Author:Yasuhiro Kohsaka, Yusuke Matsumoto, Tatsuki Kitayama


(総説)末端に官能基を有する立体規則性ポリメタクリル酸エステルの精密合成
高分子論文集,72(7):385-394 2015
Author:髙坂 泰弘; 北浦 健大; 北山 辰樹;
Abstract:メタクリル酸エステル類の立体特異性リビングアニオン重合に適用可能な官能性開始剤ならびに停止剤を開発した.リチウムN-ベンジルトリメチルシリルアミド(BnTMSNLi)を開始剤に用い,かさ高いアルミニウムフェノキシド存在下にメタクリル酸メチル(MMA)のアニオン重合を行うと,末端に二級アミノ基を有するシンジオタクチック(st-)PMMAが得られる.α-リチオイソ酪酸イソプロピルを開始剤,Me3SiOLiを助剤とするMMAのイソタクチック(it-)特異性重合をα-(クロロメチル)アクリル酸エチル(T1)で停止すると,末端にα置換アクリル酸エステル型C=C二重結合を有するit-PMMAが得られる.この末端C=C結合は多様なチオール類とのチオール–エン反応が可能であった.T1による停止反応はst-特異性重合にも有効で,BnTMSNLiとの併用でヘテロテレケリックポリマーの合成なども可能である.
Keywords:Stereospecific Anionic Polymerization; End-Functionality; Telechelic Polymer; Functional Initiator; Functional Terminator; Click Reaction; Thiol-Ene Reaction; Azide-Alkyne Cycloaddition; Polymerization Reactivity of Monomers;


(総説)メタクリル酸メチルの精密アニオン重合 : 分子量,立体規則性,末端構造の三元同時制御
日本ゴム協会誌 = Journal of the Society of Rubber Science and Technology, Japan,88(3):80-85 2015
Author:髙坂 泰弘; 北山 辰樹;
Keywords:Living Anionic Ploymerization; Stereoregularity; End-functionalization; Stereospecific Polymerization; Tacticity; Click Chemistry;


Stimuli-degradable cross-linked polymers synthesized by radical polymerization using a size-complementary [3]rotaxane cross-linker
POLYMER JOURNAL,46(1):67-72 2014
Author:Iijima, Keisuke; Kohsaka, Yasuhiro; Koyama, Yasuhito; Nakazono, Kazuko; Uchida, Satoshi; Asai, Shigeo; Takata, Toshikazu;


Anionic Alternating Copolymerization of alpha-Arylacrylates with Methyl Methacrylate: Effect of Monomer Sequence on Fluorescence
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,52(19):2806-2814 2014
Author:Kohsaka, Yasuhiro; Yamaguchi, Eiji; Kitayama, Tatsuki;


Photodegradable cross-linked polymer derived from a vinylic rotaxane cross-linker possessing aromatic disulfide axle
PURE AND APPLIED CHEMISTRY,85(4):835-842 2013
Author:Koyama, Yasuhito; Yoshii, Takahiro; Kohsaka, Yasuhiro; Takata, Toshikazu;


End-functional stereoregular poly(methyl methacrylate) with clickable C=C bonds: facile synthesis and thiol-ene reaction
POLYMER CHEMISTRY,4(19):5043-5047 2013
Author:Kohsaka, Yasuhiro; Kurata, Takashi; Kitayama, Tatsuki;


An efficient synthetic entry to rotaxanes utilising reversible cleavage of aromatic disulphide bonds
SUPRAMOLECULAR CHEMISTRY,23(1-2):65-68 2011
Author:Yoshii, Takahiro; Kohsaka, Yasuhiro; Moriyama, Taichi; Suzuki, Takao; Koyama, Yasuhito; Takata, Toshikazu;


Size-Complementary Rotaxane Cross-Linking for the Stabilization and Degradation of a Supramolecular Network
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,50(21):4872-4875 2011
Author:Kohsaka, Yasuhiro; Nakazono, Kazuko; Koyama, Yasuhito; Asai, Shigeo; Takata, Toshikazu;


Graft Polyrotaxanes: A New Class of Graft Copolymers with Mobile Graft Chains
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,50(44):10417-10420 2011
Author:Kohsaka, Yasuhiro; Koyama, Yasuhito; Takata, Toshikazu;


Main chain-type polyrotaxane with controlled ratio of rotaxanated units
CHEMISTRY LETTERS,36(2):292-293 2007
Author:Takata, Toshikazu; Kohsaka, Yasuhiro; Konishi, Gen-ichi;


Presentations
Synthesis and Degradation of Polymers Prepared from Vinyl Monomers Bearing Cyclic Hemiacetal Ester Moieties
The 10th International Conference of Modification, Degradation, and Stabilization of Polymers (MoDeSt2018) 2018
Author:Yasuhiro Kohsaka


官能基シナジーに着目したα-機能化アクリルモノマーの設計と重合
第67回高分子学会年次大会(招待講演) 2018
Author:高坂泰弘


Synthesis of Poly(conjugated ester)s by Polycondensation and Ring-Opening Polymerization for Chemically Degradable Biocompatible Polymers
IUPAC Macro2018 2018
Author:Yasuhiro Kohsaka


Atropos Polymerization: Controlled Polymerization by Programmed Termination and Application Thereof
12th IUPAC International Conference on Ionic Polymerization (IP2017) 2017
Author:Yasuhiro Kohsaka


Polymer Synthesis by Tandem Reaction of α-(Halomethyl)acrylate via Addition-Fragmentation and Click Reactions
The 12th International Conference on Advanced Polymers via Macromolecular Engineering (APME 2017) , :OC25 2017
Author:Yasuhiro Kohsaka, Keito Hagiwara, Takumi Miyazaki,


Polymer Synthesis by Conjugate Substitution of α-(Halomethyl)acrylate
日本ゴム協会 第28回エラストマー討論会(英語招待講演) 2017
Author:Yasuhiro Kohsaka


α-置換アクリル酸エステルの反応性に着目した機能高分子の精密合成
平成29年度日本化学会 東北支部秋田地区講演会 2017
Author:高坂泰弘


Preparation of a ‘One-by-one Chain-Tethered’ type sliding graft copolymer
9th International Conference on Fiber and Polymer Biotechnology (IFPB2016) 2016
Author:Chihiro Otsubo, Yasuhiro Kohsaka, Jun Araki


Anionic Polymerization of Acrylates by Onium Salts with Aluminum Lewis Acid Activator
World Congress on Living Polymerizations and Polymers (LPP16) , :P3 2016
Author:Kentaro Shirota, Yusuke Kataoka, Shogo Domae, Takehiro Kitaura, Yasuhiro Kohsaka, Tatsuki Kitayama


Anionic cyclopolymerization of α-linked diacrylate
World Congress on Living Polymerizations and Polymers (LPP16) , :P5 2016
Author:Seungmin Choi, Nobuya Tanaka, Ren Sakamoto, Yasuhiro Kohsaka, Tatsuki Kitayama


Atropos Polymerization: Controlled Polymerization by Programmed Termination
World Congress on Living Polymerizations and Polymers (LPP16) , :IL19 2016
Author:Yasuhiro Kohsaka, Tatsuki Kitayama


Polymerization of Protected 2-(Hydroxymethyl)acrylate and Insolubilization/Water-Solubilization by Acid-hydrolysis
Asian Conference on Adhesion 2016 (ACA2016) , :P36 2016
Author:Yasuhiro Kohsaka, Yusuke Matsumoto, Kazuki Yamamoto, Kazuha Suzawa, Tianyi Zhang, Yosuke Matsuhashi, Tatsuki Kitayama


One pot Synthesis of Stereoregular Graft Copolymer of Polymethacrylate One-pot synthesis of Stereoregular Graft Copolymer of Polymethacrylate via Selective Termination with Monomer-bearing Terminator via Selective Termination with Monomer-bearing Term
The 11th International Conference on Advanced Polymers via Macromolecular Engineering (APME 2014) , :1P-034 2015
Author:Shu Kano, Yasuhiro Kohsaka, Tatsuki Kitayama


Ring Opening Polymerization of β–butyrolactone by Onium Salts and Bulky Aluminum Phenoxide via O-Alkyl Scission Mechanism
The 11th International Conference on Advanced Polymers via Macromolecular Engineering (APME 2015) , :1P-035 2015
Author:Taka-aki Tanaka, Takehiro Kitaura, Yasuhiro Kohsaka, Tatsuki Kitayama


Precise synthesis of poly(methyl methacrylate): Controls of molecular weight, stereoregularity, and end-Functionality
International Conference on Smart Systems Engineering 2015 (SmaSys 2015) , :IL-3 2015
Author:Yasuhiro Kohsaka


Ethyl α-(aminomethyl)acrylate: An β-amino acid ester for pH/temperature-responsive polymers
The 11th International Conference on Advanced Polymers via Macromolecular Engineering (APME 2015) , :2F06 2015
Author:Yasuhiro Kohsaka, Yusuke Matsumoto, Tatsuki Kitayama


Ethyl α-(aminomethyl)acrylate : An amphiphilic monomer for pH- Temperature-responsive Polymers
International symposium on Amphiphilic polymers, networks gels, and membranes (APNGM15) , :IL14 2015
Author:Yasuhiro Kohsaka, Yusuke Matsumoto, Tatsuki Kitayama


End-clickable stereoregular poly(methyl methacrylate)s by termination of stereospecific anionic polymerization
nternational Science and Nature Congress (ISNaC) 2015 , :ISOC17 2015
Author:Yasuhiro Kohsaka


Atropos polymerization: Spontaneous controls of molecular weight and end-functionality via programmed termination
International Symposium on Ionic Polymerization 2015 (IP15’) , :CL17 2015
Author:Yasuhiro Kohsaka, Shoya Ishihara, Tatsuki Kitayama


pH- / Temperature-responsive Materials Prepared from β-Amino Acid Ester Carrying Polymerizable Group
The 13 th Asian Textile Conference , :266 2015
Author:Yasuhiro Kohsaka, Yusuke Matsumoto, Tatsuki Kitayama

Patents
Patents
Diol, and polycarbonate resin or polyester resin , PCT/JP2010/054467, WO 2010104199 A3