NISHIMURA Tomoki
Academic Assembly School of Science and Technology Institute of Textile Science and Technology
Faculty of Textile Science and Technology Division of Chemistry and Materials
Associate Professor
Researcher Information
Research activity information
Paper
- Ion valency–driven control of network architecture and tissue-level drug transport in protein-derived hydrogels
Han Jae Choi; Kayeong Go; Tomoki Nishimura; Azeem Ullah; Gopiraman Mayakrishnan; Ick Soo Kim; Ji Ha Lee
International Journal of Biological Macromolecules, 153100-153100, Jun. 2026
- Multi-functional photonic crystals of modular nanosheets
Seiya Yui; Takumi Mihara; Tomoki Nishimura; Yasuo Ebina; Takayoshi Sasaki; Koki Sano
Nature Communications, May 2026 - Highly Viscoelastic Supramolecular Polymers of Pt(II) Complexes with Exceptional Mechanical Reinforcement
Sehee Kim; Minju Nam; Minjoo Kim; Tomoki Nishimura; Ji Ha Lee; Sung Ho Jung; Jong Hwa Jung
Chemistry of Materials, May 2026 - High Drug Encapsulation Capacity in Cyclodextrin-Based Nanoparticles: Characterization and In Vivo Antitumor Efficacy in Tumor-Bearing Mice
Tomoki Kosugi; Mina Sakuragi; Madoka Toya; Tomoki Nishimura; Taiki Saito; Reina Kobayashi; Liliana de Campo; Kazuo Sakurai; Riku Kawasaki; Noriko Miyamoto
ACS Bio & Med Chem Au, 6(2), 168-177, Apr. 2026 - Engineering Cylindrical Macromolecular Assemblies With Zwitterionic Amino Acids for Concurrent Prolonged Circulation and Tumor Targeting
Jokichi Fukushima; Noriko Miyamoto; Shota Fujii; Tomoki Nishimura
Small, Mar. 2026 - Substrate-selective nanofactories constructed from enzyme-loaded thermoresponsive peptoid-b-oligosaccharide vesicles
Yota Okuno; Tomoki Nishimura; Yasuhiko Iwasaki; Yoshihiro Sasaki; Kazunari Akiyoshi
POLYMER JOURNAL, Nov. 2025
- Poly(2‐Propyl‐2‐Oxazoline)‐Induced Lipid Nanotube Formation in Phospholipid Multilayers
Ryosuke Mizuta; Tatsuhiko Murata; Mitsuru Ando; Tomoki Nishimura; Shin‐ichi Sawada; Kazunari Akiyoshi; Yoshihiro Sasaki
Macromolecular Rapid Communications, Nov. 2025 - Tunable pH-Responsive Release Kinetics of Doxorubicin from Iron Oxide-Loaded Cellulose Acetate Nanofibers for Localized Drug Delivery
Dayae Kang; Ji Ha Lee; Azeem Ullah; Gopiraman Mayakrishnan; Chieri Inada; Tomoki Nishimura; Jungsoon Lee; Ick Soo Kim
ACS APPLIED POLYMER MATERIALS, 7(18), 12732-12742, Sep. 2025 - Kinetically controlled crystallization-driven self-assembly of peptoid block copolymers
Renya Fukuda; Yota Okuno; Tomoki Nishimura; Yasuhiko Iwasaki
MRS COMMUNICATIONS, Sep. 2025, Refereed, Invited - Multistage Activation Barriers in the Chiral Metallosupramolecular Polymerization of Alkynylplatinum(II) Complexes
Kayeong Go; Tomoki Nishimura; Sung Ho Jung; Jong Hwa Jung
Small, May 2025 - Dopasomes: dopamine-mediated cross-linked lipid vesicles
Keita Yamana; Kouki Fujihara; Miu Maeda; Tomoki Nishimura; Riku Kawasaki; Atsushi Ikeda
Journal of Materials Chemistry B, 13(40), 12890-12894, 2025 - Self-assembly of thioether-based diblock copolymers: a comparative study of linear and bottlebrush architectures
Shin Takano; Tomoki Nishimura; Yen Theng Cheng; Markus Müllner
Polymer Chemistry, 16(19), 2244-2253, 2025 - Platinum catalyst-functionalized cylindrical graft copolymer micelles for dual catalytic and cytotoxic activity
Kyosuke Seryu; Chieri Inada; Tomoki Nishimura
Materials Advances, 6(17), 6001-6007, 2025 - Self-assembled block copolymer domains as macromolecular ion transport systems in biological membranes
Shunji Kosaka; Jokichi Fukushima; Nanami Takeuchi; Noriko Miyamoto; Liliana de Campo; Ryuji Kawano; Tomoki Nishimura
Chemical Science, 2025 - Manipulation of Macrophage Uptake by Controlling the Aspect Ratio of Graft Copolymer Micelles.
Yusuke Sakamoto; Shota Fujii; Shin Takano; Jokichi Fukushima; Mitsuru Ando; Noriyuki Kodera; Tomoki Nishimura
Nano letters, Apr. 2024 - A magnetically responsive photonic crystal of graphene oxide nanosheets
Daisuke Ogawa; Tomoki Nishimura; Yuta Nishina; Koki Sano
Nanoscale, 2024 - Macromolecular architectural effects on solution self-assembly of amphiphilic AB-type block copolymers
Naoki Ozawa; Tomoki Nishimura
Polymer Chemistry, 15(5), 349-370, 2024, Refereed - HER-2-targeted Boron Neutron Capture Therapy with Carborane-integrated Immunoliposomes Prepared via an Exchanging Reaction.
Riku Kawasaki; Ayano Oshige; Keita Yamana; Hidetoshi Hirano; Kotaro Nishimura; Yamato Miura; Ryuji Yorioka; Yu Sanada; Kaori Bando; Anri Tabata; Kazuma Yasuhara; Yusuke Miyazaki; Wataru Shinoda; Tomoki Nishimura; Hideki Azuma; Takushi Takata; Yoshinori Sakurai; Hiroki Tanaka; Minoru Suzuki; Takeshi Nagasaki; Atsushi Ikeda
Chemistry (Weinheim an der Bergstrasse, Germany), e202302486, Oct. 2023, Refereed - Exploring the effects of glyco-copolymer architectures on the solution self-assembly of amphiphilic thermoresponsive linear, star, and cyclic polymers
Naoki Ozawa; Ji Ha Lee; Isamu Akiba; Tomoki Nishimura
Polymer Chemistry, 14(33), 3834-3842, Aug. 2023 - Countercation Engineering of Graphene-Oxide Nanosheets for Imparting a Thermoresponsive Ability
Shoma Kondo; Tomoki Nishimura; Yuta Nishina; Koki Sano
ACS Applied Materials & Interfaces, 15, 37837-37844, Jul. 2023, Refereed - Development of a Water‐Dispersible Supramolecular Complex of Polyphenol with Polypeptides for Attenuation of the Allergic Response using a Mechanochemical Strategy
Riku Kawasaki; Shogo Kawamura; Tomoki Kodama; Keita Yamana; Akira Maeda; Dilimulati Yimiti; Shigeru Miyaki; Shodai Hino; Naoki Ozawa; Tomoki Nishimura; Seiji Kawamoto; Atsushi Ikeda
Macromolecular Bioscience, 2200462-2200462, Jan. 2023 - Bilayer-domain formation of thermoresponsive amphiphilic block copolymers in hybrid liposomes for synthetic molecular channels
Naoki Ozawa; Shunji Kosaka; Shota Fujii; Tomoki Nishimura
Polymer Chemistry, 14(18), 2198-2204, 2023, Refereed
Last, Corresponding - Fluorescence sensor using porous host molecules deposited on filter paper with vapochromic and mechanochromic properties
Sota Umezane; Satoshi Fukutomi; Toshikazu Ono; Yoshio Hisaeda; Tomoki Nishimura; Riku Kawasaki; Atsushi Ikeda
New Journal of Chemistry, 2023 - Circularly Polarized Luminescence Active Supramolecular Nanotubes Based on Pt Complexes That Undergo Dynamic Morphological Transformation and Helicity Inversion
Seok Gyu Kang; Ka Young Kim; Yumi Cho; Dong Yeun Jeong; Ji Ha Lee; Tomoki Nishimura; Shim Sung Lee; Sang Kyu Kwak; Youngmin You; Jong Hwa Jung
Angewandte Chemie International Edition, 61(38), Sep. 2022 - Supramolecular Shear-Thinning Glycopeptide Hydrogels for Injectable Enzyme Prodrug Therapy Applications
Yusuke Sakamoto; Fumi Suehiro; Isamu Akiba; Tomoki Nishimura
Langmuir, 38(18), 5883-5890, May 2022, Refereed
Last, Corresponding - Theranostic Agent Combining Fullerene Nanocrystals and Gold Nanoparticles for Photoacoustic Imaging and Photothermal Therapy
Riku Kawasaki; Kosuke Kondo; Risako Miura; Keita Yamana; Hinata Isozaki; Risako Shimada; Shogo Kawamura; Hidetoshi Hirano; Tomoki Nishimura; Naoki Tarutani; Kiyofumi Katagiri; Alexandra Stubelius; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi; Atsushi Ikeda
International Journal of Molecular Sciences, 23(9), 4686-4686, Apr. 2022, Refereed - A solid-in-oil-in-water emulsion: An adjuvant-based immune-carrier enhances vaccine effect
Yoshiro Tahara; Riko Mizuno; Tomoki Nishimura; Sada-atsu Mukai; Rie Wakabayashi; Noriho Kamiya; Kazunari Akiyoshi; Masahiro Goto
Biomaterials, 282, 121385-121385, Mar. 2022, Refereed - Recent advances in the self-assembly of sparsely grafted amphiphilic copolymers in aqueous solution
Yusuke Sakamoto; Tomoki Nishimura
Polymer Chemistry, 13(46), 6343-6360, 2022, Refereed - Glycopeptoid Nanospheres: Glycosylation-Induced Coacervation of Poly(sarcosine)
Yota Okuno; Tomoki Nishimura; Yoshihiro Sasaki; Kazunari Akiyoshi
Nanoscale Advances, 2022 - Bioorthogonal micellar nanoreactors for prodrug cancer therapy using an inverse-electron-demand Diels–Alder reaction
Fumi Suehiro; Shota Fujii; Tomoki Nishimura
Chemical Communications, 58(50), 7026-7029, 2022, Refereed
Last, Corresponding - Single-component nanodiscs via the thermal folding of amphiphilic graft copolymers with the adjusted flexibility of the main chain
Tomoki Nishimura; Yusuke Hatatani; Mitsuru Ando; Yoshihiro Sasaki; Kazunari Akiyoshi
Chemical Science, 13(18), 5243-5251, 2022, Refereed
Lead, Corresponding - Preparation of Aqueous Solutions with Information on Solids (ASIS) of a Mechanochromic Luminescent Tetraphenylethylene Derivative by Complexation with Polysaccharides
Riku Omokawa; Riku Kawasaki; Kouta Sugikawa; Tomoki Nishimura; Toshimi Nakaya; Atsushi Ikeda
ACS APPLIED POLYMER MATERIALS, 3(8), 3708-3713, Aug. 2021 - Manipulating the Morphology of Amphiphilic Graft-Copolymer Assemblies by Adjusting the Flexibility of the Main Chain
Tomoki Nishimura; Shota Fujii; Kazuo Sakurai; Yoshihiro Sasaki; Kazunari Akiyoshi
Macromolecules, 54(14), 7003-7009, Jul. 2021 - Thermoresponsive Carbohydrate-b-Polypeptoid Polymer Vesicles with Selective Solute Permeability and Permeable Factors for Solutes
Yota Okuno; Tomoki Nishimura; Yoshihiro Sasaki; Kazunari Akiyoshi
BIOMACROMOLECULES, 22(7), 3099-3106, Jul. 2021 - Thermoresponsive glycopolymer vesicles: in situ observation of morphological changes and triggered cargo release
Tomoki Nishimura; Yoshihiro Sasaki; Kazunari Akiyoshi
Polymer Journal, 53(11), 1251-1258, Apr. 2021, Refereed - Magnetically Navigated Protein Transduction In Vivo using Iron Oxide-Nanogel Chaperone Hybrid
Riku Kawasaki; Yoshihiro Sasaki; Tomoki Nishimura; Kiyofumi Katagiri; Kei ichi Morita; Yurina Sekine; Shin ichi Sawada; Sada atsu Mukai; Kazunari Akiyoshi
Advanced Healthcare Materials, 10(9), 2021 - Biocatalytic Hybrid Films Self-Assembled from Carbohydrate Block Copolymers and Polysaccharides for Enzyme Prodrug Therapy
Tomoki Nishimura; Yusuke Nakamura; Naoya Kinoshita; Katsuhiro Yamamoto; Yoshihiro Sasaki; Kazunari Akiyoshi
ACS Applied Bio Materials, 3(12), 8865-8871, Dec. 2020, Refereed
Lead, Corresponding - Determining the Hydration in the Hydrophobic Layer of Permeable Polymer Vesicles by Neutron Scattering
Tomoki Nishimura; Liliana de Campo; Hiroki Iwase; Kazunari Akiyoshi
Macromolecules, Aug. 2020, Refereed
Lead, Corresponding - Thermoresponsive Polysaccharide Graft Polymer Vesicles with Tunable Size and Structural Memory
Tomoki Nishimura; Shen Shishi; Yoshihiro Sasaki; Kazunari Akiyoshi
Journal of the American Chemical Society, 142(27), 11784-11790, Jul. 2020, Refereed
Lead, Corresponding - Artificial Molecular Chaperone Systems for Proteins, Nucleic Acids, and Synthetic Molecules
Tomoki Nishimura; Kazunari Akiyoshi
Bioconjugate Chemistry, 31(5), 1259-1267, May 2020, Refereed
Lead - Substrate-Sorting Nanoreactors Based on Permeable Peptide Polymer Vesicles and Hybrid Liposomes with Synthetic Macromolecular Channels
Tomoki Nishimura; Shin Hirose; Yoshihiro Sasaki; Kazunari Akiyoshi
Journal of the American Chemical Society, 142(1), 154-161, Jan. 2020, Refereed
Lead, Corresponding - Design of glyco polymer vesicles and their function as DDS nanofactories
Tomoki Nishimura; Kazunari Akiyoshi
Drug Delivery System, 34(3), 154-162, 2019 - Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery
Shigeo Takeda; Tomoki Nishimura; Kaori Umezaki; Akiko Kubo; Michiyo Yanase; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
BIOMATERIALS SCIENCE, 7(4), 1617-1622, 2019, Refereed - Intrinsically permeable polymer vesicles based on carbohydrate-conjugated poly(2-oxazoline)s synthesized using a carbohydrate-based initiator system
Tomoki Nishimura; Naoki Sumi; Yuta Koda; Yoshihiro Sasaki; Kazunari Akiyoshi
POLYMER CHEMISTRY, 10(6), 691-697, 2019, Refereed - Supramacromolecular injectable hydrogels by crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s for biomedical applications
Tomoki Nishimura; Naoki Sumi; Sada-atsu Mukai; Yoshihiro Sasaki; Kazunari Akiyoshi
Journal of Materials Chemistry B, 7(41), 6362-6369, 2019, Refereed - Biotransporting Biocatalytic Reactors toward Therapeutic Nanofactories
Tomoki Nishimura; Kazunari Akiyoshi
ADVANCED SCIENCE, 5(11), 1800801, 2018, Refereed - Synthesis and Characterization of Shell-Cross-Linked Glycopolymer Bilayer Vesicles
Tomoki Nishimura; Wei-Lun Toh; Kazunari Akiyoshi
MACROMOLECULAR RAPID COMMUNICATIONS, 39(23), 1800384, 2018, Refereed - Self-Assembled Polypeptide Nanogels with Enzymatically Transformable Surface as a Small Interfering RNA Delivery Platform
Tomoki Nishimura; Akina Yamada; Kaori Umezaki; Shin-ichi Sawada; Sada-atsu Mukai; Yoshihiro Sasaki; Kazunari Akiyoshi
BIOMACROMOLECULES, 18(12), 3913-3923, Dec. 2017, Refereed - Biotransporting Self-Assembled Nanofactories Using Polymer Vesicles with Molecular Permeability for Enzyme Prodrug Cancer Therapy
Tomoki Nishimura; Yoshihiro Sasaki; Kazunari Akiyoshi
ADVANCED MATERIALS, 29(36), 1702406, Sep. 2017, Refereed - Amylose engineering: phosphorylase-catalyzed polymerization of functional saccharide primers for glycobiomaterials
Tomoki Nishimura; Kazunari Akiyoshi
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 9(2), e1423, Mar. 2017, Refereed - Self-Assembled Nanogels of Cholesterol-Bearing Hydroxypropyl Cellulose: A Thermoresponsive Building Block for Nanogel Tectonic Materials
Yoshiro Tahara; Mizuki Sakiyama; Shigeo Takeda; Tomoki Nishimura; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
LANGMUIR, 32(47), 12283-12289, Nov. 2016, Refereed - A light sensitive self-assembled nanogel as a tecton for protein patterning materials
Tomoki Nishimura; Masahiro Takara; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
CHEMICAL COMMUNICATIONS, 52(6), 1222-1225, 2016, Refereed - Long-Lasting and Efficient Tumor Imaging Using a High Relaxivity Polysaccharide Nanogel Magnetic Resonance Imaging Contrast Agent
Minnie Chan; Jacques Lux; Tomoki Nishimura; Kazunari Akiyoshi; Adah Almutairi
BIOMACROMOLECULES, 16(9), 2964-2971, Sep. 2015, Refereed - Glyco Star Polymers as Helical Multivalent Host and Biofunctional Nano-Platform
Tomoki Nishimura; Sada-atsu Mukai; Shin-ichi Sawada; Kazunari Akiyoshi
ACS Macro Letters, 4(4), 367-371, Apr. 2015, Refereed - Amylose-Based Cationic Star Polymers for siRNA Delivery
Tomoki Nishimura; Kaori Umezaki; Sada-atsu Mukai; Shin-ichi Sawada; Kazunari Akiyoshi
BIOMED RESEARCH INTERNATIONAL, 2015, 962941, 2015, Refereed, Invited - A bimolecular micelle constructed from amphiphilic pillar[5]arene molecules.
Tomoki Nishimura; Yusuke Sanada; Takuma Matsuo; Tadashi Okobira; Efstratios Mylonas; Naoto Yagi; Kazuo Sakurai
Chemical communications (Cambridge, England), 49(29), 3052-4, Apr. 2013, Refereed - A simple visual sensor with the potential for determining the concentration of fluoride in water at environmentally significant levels
Tomoki Nishimura; Su-Ying Xu; Yun-Bao Jiang; John S. Fossey; Kazuo Sakurai; Steven D. Bull; Tony D. James
CHEMICAL COMMUNICATIONS, 49(5), 478-480, 2013, Refereed - Pyrene-anchored boronic acid receptors on carbon nanoparticle supports: fluxionality and pore effects
Katherine Lawrence; Tomoki Nishimura; Peter Haffenden; John M. Mitchels; Kazuo Sakurai; John S. Fossey; Steven D. Bull; Tony D. James; Frank Marken
NEW JOURNAL OF CHEMISTRY, 37(7), 1883-1888, 2013, Refereed - Thermodynamics of Lipoplex Formation: Relationship between the Lipid Alkyl Tail Length and Thermodynamic Functions
Shota Fujii; Tomoki Nishimura; Kazuo Sakurai
CHEMISTRY LETTERS, 41(5), 501-503, May 2012, Refereed - A Stimulus-Responsive Shape-Persistent Micelle Bearing a Calix[4]arene Building Block: Reversible pH-Dependent Transition between Spherical and Cylindrical Forms
Shota Fujii; Yusuke Sanada; Tomoki Nishimura; Isamu Akiba; Kazuo Sakurai; Naoto Yagi; Efstratios Mylonas
LANGMUIR, 28(6), 3092-3101, Feb. 2012, Refereed - Quaternary-ammonium-bearing Aromatic Surfactants: Effect of the Alkyl Chain Positions on Their Micelle and DNA-complex Structures
Takuma Matsuo; Shota Fujii; Yumi Kamikawa; Tomoki Nishimura; Yusuke Sanada; Shinichi Mochizuki; Kazuo Sakurai
CHEMISTRY LETTERS, 40(12), 1340-1342, Dec. 2011, Refereed - Metal-ion induced transition from multi- to single-bilayer tubes in histidine bearing lipids and formation of monodisperse Au nanoparticles
Tomoki Nishimura; Takuma Matsuo; Kazuo Sakurai
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 13(35), 15899-15905, 2011, Refereed - Synthesis of a Highly Hydrophobic Cationic Lipid and Structural and Thermodynamic Studies for Interaction with DNA
Tomoki Nishimura; Takeshi Cho; Andrew M. Kelley; Magdalena E. Powell; John S. Fossey; Steven D. Bull; Tony D. James; Hiroyasu Masunaga; Isamu Akiba; Kazuo Sakurai
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 83(9), 1010-1018, Sep. 2010, Refereed - Cation-specific Transition from Vesicle to Lamella for an Aromatic Diamine Lipid in Aqueous Solutions
Tomoki Nishimura; Hiroyasu Masunaga; Hiroki Ogawa; Isamu Akiba; Kazuo Sakurai
CHEMISTRY LETTERS, 39(7), 686-687, Jul. 2010, Refereed - DNA binding of tilorone: H-1 NMR and calorimetric studies of the intercalation
Tomoki Nishimura; Tadashi Okobira; Andrew M. Kelly; Naohiko Shimada; Yoichi Takeda; Kazuo Sakurai
BIOCHEMISTRY, 46(27), 8156-8163, Jul. 2007, Refereed - DNA conformational switching by use of an intercalator and its receptor
Tomoki Nishimura; Yoichi Takeda; Naohiko Shimada; Kazuo Sakurai
CHEMISTRY LETTERS, 36(3), 388-389, Mar. 2007, Refereed
Affiliated academic society
Research Themes
- Graft Polymer Discs: A Novel Platform for Membrane Protein Analysis
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Research (Exploratory)
Shinshu University
30 Jun. 2022 - 31 Mar. 2024 - Creation of artificial ion channels based on block copolymers
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Shinshu University
01 Apr. 2022 - 31 Mar. 2025 - ブロックポリマーイオンチャネルの創製
科学研究費助成事業, 日本学術振興会, 基盤研究(B)
信州大学
01 Apr. 2022 - 31 Mar. 2025 - 高分子フォルダマーを基盤としたDDSナノファクトリーの創製
科学技術振興機構, 戦略的な研究開発の推進/創発的研究支援事業
2021 - 2027
