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KITAGUCHI Yoshiaki

Academic OrganizationAcademic Assembly School of Medicine and Health Sciences Institute of MedicineTEL+81-263-37-2631
Education and Research OrganizationUniversity Hospital Respirology & Infectious Disease & AllergologyFAX+81-263-36-3722
PositionSenior Assistant ProfessorMail Address
Address3-1-1, Asahi, Matsumoto City 390-8621Web site

Profile

Research Field
Clinical analysis of COPD, asthma, combined pulmonary fibrosis and emphysema (CPFE), asthma COPD overlap (ACO), pulmonary function, image analysis, genetic analysis
Academic Background
Graduate School
Shinshu University School of Medicine , 2010

College
Shinshu University School of Medicine , 1999
Awards
2011
Research Career
Overseas Education
2007-2008 , Internal Medicine, Virginia Common-Wealth University, VA, USA
2006-2007 , Health Science Center, University of Colorado, CO, USA

Research

Books, Articles, etc.
Books
COPDのパーフェクト呼吸管理, Part.2 治療, 2診断基準と病期分類, Respica 17 2, 21-24
メディカ出版 2019
Author:北口良晃


炎症病態からみたACOS (特集 喘息-COPDオーバーラップ症候群(ACOS)の病態と臨床), 喘息・アレルギー = Asthma and allergy 29 2, 165-169
メディカルレビュー社 2016(Oct.)
Author:北口 良晃; 花岡 正幸;
Keywords:好酸球; Th2炎症; 好中球; エンドタイプ; バイオマーカー;


COPDと間質性肺炎の合併, Annual Review 2011 , 69-74
中外医学社 2011
Author:北口良晃、藤本圭作


リッチモンド便り, 信州医学雑誌 56 4, 205-206
信州医学会 2008
Author:北口 良晃


COPDの急性増悪の薬物療法 (特集 COPDの急性増悪をめぐって), 呼吸と循環 55 4, 411-416
医学書院 2007(Apr.)
Author:北口 良晃; 藤本 圭作;


呼吸器疾患の胸部単純X線写真 -見落としのない読影のポイント- 閉塞性肺疾患(COPD, LAM, DPB, Bronchiectasis), 呼吸と循環 92 4, 603-609
診断と治療社 2004(Apr. 01)
Author:北口良晃


骨盤放線菌症の一例, 長野赤十字病院医誌 16
2002
Author:北口良晃、輪湖正、山田哲、天野雅子、丸山篤敬、岡嵜洋一、本藤徹、渡辺正秀、羽田悟


Articles
Clinical characteristics of non-idiopathic pulmonary fibrosis, progressive fibrosing interstitial lung diseases A single-center retrospective study
MEDICINE,100(13) 2021
Author:Komatsu, Masamichi; Yamamoto, Hiroshi; Kitaguchi, Yoshiaki; Kawakami, Satoshi; Matsushita, Mina; Uehara, Takeshi; Kinjo, Takumi; Wada, Yosuke; Ichiyama, Takashi; Urushihata, Kazuhisa; Ushiki, Atsuhito; Yasuo, Masanori; Hanaoka, Masayuki;
Keywords:idiopathic pulmonary fibrosis; interstitial lung disease; progressive fibrosing interstitial lung disease;


Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice
RESPIRATORY RESEARCH,22(1) 2021
Author:Morichika, Daisuke; Taniguchi, Akihiko; Oda, Naohiro; Fujii, Utako; Senoo, Satoru; Itano, Junko; Kanehiro, Arihiko; Kitaguchi, Yoshiaki; Yasuo, Masanori; Hanaoka, Masayuki; Satoh, Takashi; Akira, Shizuo; Kiura, Katsuyuki; Maeda, Yoshinobu; Miyahara, Nobuaki;
Keywords:Chronic obstructive pulmonary disease; COPD; HGF; VEGF;


Automated Diseased Lung Volume Percentage Calculation in Quantitative CT Evaluation of Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY,45(4):649-658 2021
Author:Kitaguchi, Yoshiaki; Fujimoto, Keisaku; Droma, Yunden; Yasuo, Masanori; Wada, Yosuke; Ueno, Fumika; Kinjo, Takumi; Kawakami, Satoshi; Fukushima, Kiyoyasu; Hanaoka, Masayuki;
Keywords:quantitative CT; COPD; IPF; CPFE; LungVision;


The Interstitial Lung Disease-Gender-Age-Physiology Index Can Predict the Prognosis in Surgically Resected Patients with Interstitial Lung Disease and Concomitant Lung Cancer
RESPIRATION,99(1):9-18 2020(Jan.)
Author:Ueno, Fumika; Kitaguchi, Yoshiaki (corresponding author); Shiina, Takayuki; Asaka, Shiho; Yasuo, Masanori; Wada, Yosuke; Kinjo, Takumi; Yoshizawa, Akihiko; Hanaoka, Masayuki;


The Gly82Ser mutation in AGER contributes to pathogenesis of pulmonary fibrosis in combined pulmonary fibrosis and emphysema (CPFE) in Japanese patients
SCIENTIFIC REPORTS,10(1):12811 2020
Author:Kinjo, Takumi; Kitaguchi, Yoshiaki (corresponding author); Droma, Yunden; Yasuo, Masanori; Wada, Yosuke; Ueno, Fumika; Ota, Masao; Hanaoka, Masayuki;


Differences Between Central Airway Obstruction and Chronic Obstructive Pulmonary Disease Detected with the Forced Oscillation Technique
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,15:1425-1434 2020
Author:Yasuo, Masanori; Kitaguchi, Yoshiaki; Tokoro, Yayoi; Kosaka, Makoto; Wada, Yosuke; Kinjo, Takumi; Ushiki, Atsuhito; Yamamoto, Hiroshi; Hanaoka, Masayuki;


Prognosis of patients with acute exacerbation of combined pulmonary fibrosis and emphysema: a retrospective single-centre study
BMC PULMONARY MEDICINE,20(1) 2020
Author:Ikuyama, Yuichi; Ushiki, Atsuhito; Kosaka, Makoto; Akahane, Jumpei; Mukai, Yuichi; Araki, Taisuke; Kitaguchi, Yoshiaki; Tateishi, Kazunari; Urushihata, Kazuhisa; Yasuo, Masanori; Yamamoto, Hiroshi; Hanaoka, Masayuki;


REDUCTION OF ANTIOXIDANT ACTIVITY IN RATS OF EMPHYSEMA WITH PULMONARY HYPERTENSION INDUCED BY SU5416/HYPOXIA: POTENTIAL ROLES OF VASCULAR ENDOTHELIAL GROWTH FACTOR
RESPIROLOGY,24:81-81 2019(Nov.)
Author:Wada, Yosuke; Kitaguchi, Yoshiaki; Yasuo, Masanori; Hanaoka, Masayuki;


The relationship between acrolein and oxidative stress in COPD: in systemic plasma and in local lung tissue
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,14:1527-1537 2019
Author:Yasuo, Masanori; Droma, Yunden; Kitaguchi, Yoshiaki; Ito, Michiko; Imamura, Hitomi; Kawakubo, Masatomo; Hanaoka, Masayuki;


Bevacizumab-induced tracheoesophageal fistula in a patient suffering from lung cancer with bulky subcarinal lymph node: a case report
NAGOYA JOURNAL OF MEDICAL SCIENCE,80(1):129-134 2018(Feb.)
Author:Nishie, Kenichi; Yasuo, Masanori; Kitaguchi, Yoshiaki; Kobayashi, Nobumitsu; Tateishi, Kazunari; Ushiki, Atsuhito; Urushihata, Kazuhisa; Yamamoto, Hiroshi; Ideura, Gen; Hanaoka, Masayuki;


The Contribution of Genetic Variants of the Peroxisome Proliferator-Activated Receptor-Alpha Gene to High-Altitude Hypoxia Adaptation in Sherpa Highlanders
HIGH ALTITUDE MEDICINE & BIOLOGY 2018
Author:Kinota, Fumiya; Droma, Yunden; Kobayashi, Nobumitsu; Horiuchi, Toshimichi; Kitaguchi, Yoshiaki; Yasuo, Masanori; Ota, Masao; Hanaoka, Masayuki;


Diversity of respiratory impedance based on quantitative computed tomography in patients with COPD
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,13:1841-1849 2018
Author:Wada, Yosuke; Kitaguchi, Yoshiaki (corresponding author); Yasuo, Masanori; Ueno, Fumika; Kawakami, Satoshi; Fukushima, Kiyoyasu; Fujimoto, Keisaku; Hanaoka, Masayuki;


Clinical significance of preoperative serum albumin level for prognosis in surgically resected patients with non-small cell lung cancer Comparative study of normal lung, emphysema, and pulmonary fibrosis
LUNG CANCER,111:88-95 2017(Sep.)
Author:Miura, Kentaro; Hamanaka, Kazutoshi; Koizumi, Tomonobu; Kitaguchi, Yoshiaki; Terada, Yukihiro; Nakamura, Daisuke; Kumeda, Hirotaka; Agatsuma, Hiroyuki; Hyogotani, Akira; Kawakami, Satoshi; Yoshizawa, Akihiko; Asaka, Shiho; Ito, Ken-ichi;


Outcomes of Surgically Treated Pneumothorax in Patients with Interstitial Pneumonia
信州医学雑誌,65(3):163-170 2017(Jun. 10)
Author:Miura K, Kondo R, Kitaguchi Y


The Preoperative Composite Physiologic Index May Predict Mortality in Lung Cancer Patients with Combined Pulmonary Fibrosis and Emphysema
RESPIRATION,94(2):198-206 2017
Author:Ueno, Fumika; Kitaguchi, Yoshiaki (corresponding author); Shiina, Takayuki; Asaka, Shiho; Miura, Kentaro; Yasuo, Masanori; Wada, Yosuke; Yoshizawa, Akihiko; Hanaoka, Masayuki;


Efficacy of tiotropium and indacaterol monotherapy and their combination on dynamic lung hyperinflation in COPD: a random open-label crossover study
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,12:3195-3201 2017
Author:Fujimoto, Keisaku; Yamazaki, Haruna; Ura, Midori; Kitaguchi, Yoshiaki;


Self-assessment of Allergic Rhinitis and Asthma (SACRA) Questionnaire-based Allergic Rhinitis Treatment Improves Asthma Control in Asthmatic Patients with Allergic Rhinitis
INTERNAL MEDICINE,56(1):31-39 2017
Author:Yasuo, Masanori; Kitaguchi, Yoshiaki; Komatsu, Yoshimichi; Hama, Mineyuki; Koizumi, Tomonobu; Agatsuma, Toshihiko; Ichiyama, Takashi; Kato, Akane; Moteki, Hideaki; Hanaoka, Masayuki;


Comparison of pulmonary function in patients with COPD, asthma-COPD overlap syndrome, and asthma with airflow limitation
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,11:991-997 2016
Author:Kitaguchi, Yoshiaki; Yasuo, Masanori; Hanaoka, Masayuki;


Characteristics and Predictors of Mortality in Patients with Combined Pulmonary Fibrosis and Emphysema Syndrome and Lung Cancer
J Pulm Respir Med,5(263):2 2015
Author:Kitaguchi Y, Fujimoto K, Hotta J, Horie S, Hirayama J, Hanaoka M


Hydrogen Peroxide Content and pH of Expired Breath Condensate from Patients with Asthma and COPD
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,11(1):81-87 2014(Feb.)
Author:Murata, Kazuya; Fujimoto, Keisaku; Kitaguchi, Yoshiaki; Horiuchi, Toshimichi; Kubo, Keishi; Honda, Takayuki;


Pulmonary function impairment in patients with combined pulmonary fibrosis and emphysema with and without airflow obstruction
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,9:805-810 2014
Author:Kitaguchi, Yoshiaki; Fujimoto, Keisaku; Hanaoka, Masayuki; Honda, Takayuki; Hotta, Junichi; Hirayama, Jiro;


Annual changes in pulmonary function in combined pulmonary fibrosis and emphysema: Over a 5-year follow-up
RESPIRATORY MEDICINE,107(12):1986-1992 2013(Dec.)
Author:Kitaguchi, Yoshiaki; Fujimoto, Keisaku; Hayashi, Ryoichi; Hanaoka, Masayuki; Honda, Takayuki; Kubo, Keishi;


Additive efficacy of short-acting bronchodilators on dynamic hyperinflation and exercise tolerance in stable COPD patients treated with long-acting bronchodilators
RESPIRATORY MEDICINE,107(3):394-400 2013(Mar.)
Author:Kitaguchi, Yoshiaki; Fujimoto, Keisaku; Komatsu, Yoshimichi; Hanaoka, Masayuki; Honda, Takayuki; Kubo, Keishi;


肺気腫型および非肺気腫型慢性閉塞性肺疾患における長時間作用型気管支拡張薬の効果の比較
日本呼吸ケア・リハビリテーション学会誌,22(3):398-404 2012(Dec.)
Author:北口良晃、藤本圭作、小松佳道、神田慎太郎、漆畑一寿、花岡正幸、久保惠嗣
Keywords:長時間作用性抗コリン薬; 長時間作用性β₂刺激薬; 慢性閉塞性肺疾患(COPD); フェノタイプ; 動的肺過膨張;


Imbalance of Apoptosis and Cell Proliferation Contributes to the Development and Persistence of Emphysema
LUNG,190(1):69-82 2012(Feb.)
Author:Lee, Ji-Hyun; Hanaoka, Masayuki; Kitaguchi, Yoshiaki; Kraskauskas, Donatas; Shapiro, Leland; Voelkel, Norbert F.; Taraseviciene-Stewart, Laima;


Acute Exacerbation of Pulmonary Fibrosis in Syndrome of Combined Pulmonary Fibrosis and Emphysema Following Lung
Shinshu Medical Journal,60:149-156 2012
Author:Kitaguchi Y, Fujimoto K, Horie S, Ishi K, Hirayama J, Machida R, Hanaoka M, Kubo K


Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,7:283-289 2012
Author:Kitaguchi, Yoshiaki; Komatsu, Yoshimichi; Fujimoto, Keisaku; Hanaoka, Masayuki; Kubo, Keishi;


Acrolein Induces Endoplasmic Reticulum Stress and Causes Airspace Enlargement
PLOS ONE,7(5) 2012
Author:Kitaguchi, Yoshiaki; Taraseviciene-Stewart, Laimute; Hanaoka, Masayuki; Natarajan, Ramesh; Kraskauskas, Donatas; Voelkel, Norbert F.;


Carbocisteine Protects Against Emphysema Induced by Cigarette Smoke Extract in Rats
CHEST,139(5):1101-1108 2011(May)
Author:Hanaoka, Masayuki; Droma, Yunden; Chen, Yan; Agatsuma, Toshihiko; Kitaguchi, Yoshiaki; Voelkel, Norbert F.; Kubo, Keishi;


Usefulness of the Measurement of Fractional Exhaled Nitric Oxide in Asthmatic Patients: Correlation with Pulmonary Function, Asthma Control and Health Status
Shinshu Medical Journal,59:239-247 2011
Author:Kitaguchi Y, Fujimoto K, Ono M, Komatsu Y, Honda T, Kubo K


Comparison of efficacy of long-acting bronchodilators in emphysema dominant and emphysema nondominant chronic obstructive pulmonary disease
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,6:219-227 2011
Author:Fujimoto, Keisaku; Kitaguchi, Yoshiaki; Kanda, Shintaro; Urushihata, Kazuhisa; Hanaoka, Masayuki; Kubo, Keishi;


Clinical characteristics of combined pulmonary fibrosis and emphysema
RESPIROLOGY,15(2):265-271 2010(Feb.)
Author:Kitaguchi, Yoshiaki; Fujimoto, Keisaku; Hanaoka, Masayuki; Kawakami, Satoshi; Honda, Takayuki; Kubo, Keishi;


Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD
RESPIROLOGY,12(1):93-99 2007(Jan.)
Author:Fujimoto, Keisaku; Yoshiike, Fumiaki; Yasuo, Masanori; Kitaguchi, Yoshiaki; Urushihata, Kazuhisa; Kubo, Keishi; Honda, Takayuki;


Clinical analysis of chronic obstructive pulmonary disease phenotypes classified using high-resolution computed tomography
RESPIROLOGY,11(6):731-740 2006(Nov.)
Author:Fujimoto, Keisaku; Kitaguchi, Yoshiaki; Kubo, Keishi; Honda, Takayuki;


Characteristics of COPD phenotypes classified according to the findings of HRCT
RESPIRATORY MEDICINE,100(10):1742-1752 2006(Oct.)
Author:Kitaguchi, Yoshiaki; Fujimoto, Keisaku; Kubo, Keishi; Honda, Takayuki;


Presentations
Patients with COPD carrying the Gly82Ser mutation of the AGER are susceptible to the combined pulmonary fibrosis and emphysema in Japanese
American Thoracic Society 2020 Virtual 2020(Aug. 01)
Presenter:Takumi Kinjo, Yoshiaki Kitaguchi, Masanori Yasuo, Yosuke Wada, Fumika Ueno, Yunden Droma, Masao Ota, Masayuki Hanaoka


Usefulness of software-based quantification for a computed tomography image analysis that simultaneously detects emphysema and pulmonary fibrosis
American Thoracic Society 2020 Virtual 2020(Aug. 01)
Presenter:Yoshiaki Kitaguchi, Keisaku Fujimoto, Masanori Yasuo, Yosuke Wada, Fumika Ueno, Takumi Kinjo, Satoshi Kawakami, Kiyoyasu Fukushima, Masayuki Hanaoka


Correlation between pulmonary function and the software-based quantification of the degree of emphysema and airway wall thickening in patients with COPD
American Thoracic Society 2017(May 22)
Presenter:Yosuke Wada, Yoshiaki Kitaguchi, Masanori Yasuo, Nobumitsu Kobayashi, Kazunari Tateishi, Kazuhisa Urushihata, Atsuhito Ushiki, Hiroshi Yamamoto and Masayuki Hanaoka


Clinical analysis of patients with combined pulmonary fibrosis and emphysema complicated with lung cancer
American Thoracic Society 2015
Presenter:Kitaguchi Y, Hotta J, Hirayama J, Fujimoto K, Hanaoka M


Evaluation Of The Clinical Utility And Simplicity Of COPD Assessment Test In Patients With Chronic Obstructive Pulmonary Disease
American Thoracic Society 2013
Presenter:Kitaguchi Y, Yasuo M, Hanaoka M, Ichiyama T, Tokoro Y, Hama M, Ushiki A, Urushihata K, Kubo K


Usefulness of the Measurement of Fractional Exhaled Nitric Oxide in Asthmatic Patients: Correlation with Pulmonary Function, Asthma Control and Health Status
American Thoracic Society 2012
Presenter:Kitaguchi Y, Fujimoto K, Ono M, Komatsu Y, Honda T, Kubo K


Comparison of efficacy of long-acting bronchodilators in patients with emphysema-dominant COPD and emphysema-nondominant COPD
American Thoracic Society 2011
Presenter:Kitaguchi Y, Fujimoto K, Komatsu Y, Kanda S, Urushihata K, Hanaoka M, Kubo K


Clinical characteristics of combined pulmonary fibrosis and emphysema
American Thoracic Society 2010
Presenter:Kitaguchi Y, Fujimoto K, Hanaoka M, Kawakami S, Honda T, Kubo K


Acrolein induces endoplasmic reticulum stress and causes airspace enlargement
American Thoracic Society 2008
Presenter:Kitaguchi Y, Taraseviciene-Stewart L, Hanaoka M, Natarajan R, Kraskauskas D, Voelkel NF


Characteristics of COPD subtypes classified according to the findings of high-resolution computecd tomography
American Thoracic Society 2004
Presenter:Kitaguchi Y, Fujimoto K, Kubo K