Kamiyoshi, Akiko | Shinshu University Researcher Directory

Academic Organization	Academic Assembly　School of Medicine and Health Sciences　Institute of Medicine	TEL
Education and Research Organization	Interdisciplinary Cluster for Cutting Edge Research　Institute for Biomedical Sciences	FAX
Position	Assistant Professor	Mail Address
Address	3-1-1 Asahi, Matsumoto, Nagano 390-8621	Web site

Profile

Assigned Class: School of Medicine　Department of Cardiovascular Research

Research Field: Laboratory animal science

Current Subject: Mechanism of protective effects of CGRP on liver injury
Keywords:CGRP , hepatitis
Metabolic regulations by adrenomedullin-RAMP2 system
Keywords:AM , metabolic syndrome

Academic Societies: Academic Societies
The Japanese Circulation Society
Japanese Association for Laboratory Animal Science
The Japan Endocrine Society

Academic Background: Graduate School
Toho University , (Biomolecular Science , Graduate School of Science) , 2000

College
Toho University , (Faculity of Science) , 1998

Degree
Doctor(Medicine) , Shinshu University

Research Career: Research Career
2006- , Shinshu University Graduate of medicine Assistant Professor
2005-2006 , Nagano Techno Foundation Researcher
2005-2005 , Shinshu University Graduate ofmedicine Encourage Researcher
2000-2005 , Shinshu University Research Center for Human and Environmental Sciences Technical Assistant

Research

Books, Articles, etc.: Books
エネルギー代謝制御におけるAM, AM2の機能分化と相互作用, Medical Science Digest 48 6, 38-40
2022(Jun.)
Author:神吉昭子、桜井敬之、新藤隆行

アドレノメデュリン-RAMP2シグナル, 細胞工学 35 1, 33-38
2016
Author:新藤隆行、桜井敬之、神吉昭子、新藤優佳、田中愛、小山晃英

アドレノメデュリン-RAMP2システムによる、白色脂肪、褐色脂肪の脂質、エネルギー代謝制御, 血管 37 4, 135-139
2014
Author:神吉昭子、桜井敬之、河手久香、新藤優佳、植竹龍一、山内啓弘、五十嵐恭子、鳥山佑一、田中愛、劉甜、羨鮮、今井章、翟留玉、大和慎治、新藤隆行

再生医療の展望：再生医療と遺伝子工学-ES細胞の利用を例に-, 信州医学雑誌 51 , 361-362
2003
Author:田川陽一、神吉昭子

Articles
Receptor Activity Modifying Protein RAMP Sub-Isoforms and Their Functional Differentiation, Which Regulates Functional Diversity of Adrenomedullin
Biology,11(5):788 2022(May)
Author:Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Sakurai T.

Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-b-Smads signaling and myofibroblast differentiation
Endocrinology,162(8):bqab090 2021(Aug.)
Author:Wei Y, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Kakihara S, Zhao Y, Aruga K, Sanjo H, Shindo T.

Adrenomedullin-receptor activity-modifying protein 2 system ameliorates subretinal fibrosis by suppressing epithelial-mesenchymal transition in age-related macular degeneration
Am J Pathol,191(4):652-668 2021(Apr.)
Author:Tanaka M, Kakihara S, Hirabayashi K, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Aruga K, Yamauchi A, Murata T, Shindo T.

Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress
Endocrinology,162(3):bqab001 2021(Mar.)
Author:Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T.

Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts
Oncogene,39(9):1914-1930 2020(Feb.)
Author:Dai K, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Tanaka M, Kakihara S, Matsui S, Shindo T.

Production of genetically engineered mice with higher efficiency, lower mosaicism, and multiplexing capability using maternally expressed Cas9
Sci Rep,10(1):1091 2020(Jan.)
Author:Sakurai T, Kamiyoshi A, Kawate H, Watanabe S, Sato M, Shindo T.

Endogenous Calcitonin Gene-Related Peptide Deficiency Exacerbates Postoperative Lymphedema by Suppressing Lymphatic Capillary Formation and M2 Macrophage Accumulation
Am J Pathol,189(12):2487-2502 2019(Dec.)
Author:Matsui S, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Dai K, Cui N, Wei Y, Tanaka M, Kakihara S, Nakamura K, Yamauchi A, Ishida K, Tanaka S, Kawamata M, Shindo T.

Bindel-PCR: a novel and convenient method for identifying CRISPR/Cas9-induced biallelic mutants through modified PCR using Thermus aquaticus DNA polymerase
Sci Rep,9(1):9923 2019(Jul. 09)
Author:Sakurai T, Kamiyoshi A, Takei N, Watanabe S, Sato M, Shindo T.

Development of a Novel Model of Central Retinal Vascular Occlusion and the Therapeutic Potential of the Adrenomedullin-Receptor Activity-Modifying Protein 2 System
AMERICAN JOURNAL OF PATHOLOGY,189(2):449-466 2019(Feb.)
Author:Hirabayashi, Kazutaka; Tanaka, Masaaki; Imai, Akira; Toriyama, Yuichi; Iesato, Yasuhiro; Sakurai, Takayuki; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Tanaka, Megumu; Dai, Kun; Cui, Nanqi; Wei, Yangxuan; Nakamura, Keisei; Iida, Shiho; Matsui, Shuhei; Yamauchi, Akihiro; Murata, Toshinori; Shindo, Takayuki;

Regulation of cardiovascular development and homeostasis by the adrenomedullin-RAMP system
PEPTIDES,111:55-61 2019(Jan.)
Author:Shindo, Takayuki; Tanaka, Megumu; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Yamauchi, Akihiro; Sakurai, Takayuki;

RAMP3 deficiency enhances postmenopausal obesity and metabolic disorders
PEPTIDES,110:10-18 2018(Dec.)
Author:Liu, Teng; Kamiyoshi, Akiko; Tanaka, Megumu; Iida, Shiho; Sakurai, Takayuki; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Hirabayashi, Kazutaka; Dai, Kun; Cui, Nanqi; Tanaka, Masaaki; Wei, Yangxuan; Nakamura, Keisei; Matsui, Shuhei; Yamauchi, Akihiro; Shindo, Takayuki;

Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline.
J Hypertens,36(4):876-891 2018(Apr.)
Author:Zhai L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Xian X, Hirabayashi K, Dai K, Cui N, Tanimura K, Liu T, Wei Y, Tanaka M, Tomiyama H, Yamauchi A, Igarashi K, Shindo T.

Placental extract ameliorates non-alcoholic steatohepatitis (NASH) by exerting protective effects on endothelial cells.
Heliyon,3(9):e00416 2017(Sep. 27)
Author:Yamauchi A, Kamiyoshi A, Koyama T, Iinuma N, Yamaguchi S, Miyazaki H, Hirano E, Kaku T, Shindo T.

Endogenous Calcitonin Gene-Related Peptide Regulates Lipid Metabolism and Energy Homeostasis in Male Mice.
Endocrinology,158(5):1194-1206 2017(May)
Author:Liu T, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Yang L, Tanaka M, Xian X, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T.

Vasoprotective Activities of the Adrenomedullin-RAMP2 System in Endothelial Cells.
Endocrinology,158(5):1359-1372 2017(May)
Author:Xian X, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Koyama T, Kawate H, Yang L, Liu T, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T.

Adrenomedullin Suppresses Vascular Endothelial Growth Factor-Induced Vascular Hyperpermeability and Inflammation in Retinopathy.
Am J Pathol,187(5):999-1015 2017(May)
Author:Imai A, Toriyama Y, Iesato Y, Hirabayashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Xian X, Zhai L, Dai K, Tanimura K, Liu T, Cui N, Yamauchi A, Murata T, Shindo T.

The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumor metastasis
Cardiovasc Res,111(4):398-409 2016
Author:Tanaka M, Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Yamauchi A, Igarashi K, Taniguchi S, Shindo T

A non-inheritable maternal Cas9-based multiple-gene editing system in mice
Sci Rep,6(20011) 2016
Author:Sakurai T, Kamiyoshi A, Kawate H, Mori C, Watanabe S, Tanaka M, Uetake R, Sato M, Shindo T

Adrenomedullin-RAMP2 System in Vascular Endothelial Cells
J Atheroscler Thromb,22(7):647-53 2015
Author:Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Shindo T

Pathophysiological function of endogenous calcitonin gene-related peptide in ocular vascular diseases
Am J Pathol,185(6):1783-94 2015
Author:Toriyama Y, Iesato Y, Imai A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Igarashi K, Tanaka M, Liu T, Xian X, Zhai L, Owa S, Murata T, Shindo T

Functional differentiation of RAMP2 and RAMP3 in their regulation of the vascular system
J Mol Cell Cardiol,77:73-85 2014
Author:Yamauchi A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Igarashi K, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T

Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia
Peptides,62:21-31 2014
Author:Igarashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L. Owa S, Koyama T, Uetake R, Ihara M, Shindo T

A single blastocyst assay optimized for detecting CRISPR/Cas9 system-induced indel mutations in mice
BMC Biotechnol,14:69 2014
Author:Sakurai T, Watanabe S, Kamiyoshi A, Sato M, Shindo T

Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection
PLoS One,9(2):e87667 2014
Author:Uetake R, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Yoshizawa T, Koyama T, Yang L, Toriyama Y, Yamauchi A, Igarashi K, Tanaka M, Kuwabara T, Mori K, Yanagita M, Mukoyama M, Shindo T

Regulation of adrenomedullin and its family peptide by RAMP system--lessons from genetically engineered mice
Curr Protein Pept Sci,14(5):347-357 2013
Author:Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Shimoyama N, Iinuma N, Arai T, Miyagawa S

Adrenomedullin-RAMP2 system is crucially involved in retinal angiogenesis
Am J Pathol,182(6):2380-2390 2013
Author:Iesato Y, Toriyama Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Igarashi K, Murata T, Shindo T

Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury
J Mol Cell Cardiol,59:55-66 2013
Author:Yang L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Iesato Y, Uetake R, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Shindo T

Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system
Hypertension,61(2):341-351 2013
Author:Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T

Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis
Circulation,127(7):842-853 2013
Author:Koyama T, Ochoa-Callejero L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Arai T, Yoshizawa T, Iesato Y, Lei Y, Uetake R, Okimura A, Yamauchi A, Tanaka M, Igarashi K, Toriyama Y, Kawate H, Adams RH, Kawakami H, Mochizuki N, Martinez A, Shindo T

Adrenomedullin-RAMP2 system in cardiovascular development and homeostasis
Current Hypertension Reviews,7:217-227 2011
Author:Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y

Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling
Peptides,32(9):1855-1865 2011
Author:Arai T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Iesato Y, Koyama T, Yoshizawa T, Uetake R, Yamauchi A, Yang L, Kawate H, Ogawa S, Kobayashi A, Miyagawa S, Shindo T

Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver
Peptides,31(5):865-871 2010
Author:Iinuma N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Arai T, Yoshizawa T, Koyama T, Uetake R, Kawate H, Muto S, Tagawa Y, Miyagawa S, Shindo T

Endogenous a-calcitonin gene-related peptide mitigates liver fibrosis in chronic hepatitis induced byrepeated administration of concanavalin A
Liver Int,29(5):642-649 2009
Author:Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Iinuma N, Kawate H, Yoshizawa T, Koyama T, Muto S, Shindo T

Rapid zygosity determination in mice by SYBR Green real-time genomic PCR of a crude DNA solution
Transgenic Res,17(1):149-155 2008
Author:Sakurai T, Kamiyoshi A, Watanabe S, Sato M, Shindo T

GPCRmodulator protein RAMP2 is essential for angiogenesis and vascular integrity
J Clin Invest,118(1):29-39 2008
Author:Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T

Endogenous alphaCGRP protects against concanavalin A-induced hepatitis in mice
Biochem Biophys Res Commun,343(1):152-158 2006
Author:Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Fukuchi J, Kawate H, Muto S, Tagawa Y, Shindo T

Characterization of cytochrome P450 expression in murine embryonic stem cell-derived hepatic tissue system
DRUG METABOLISM AND DISPOSITION,34(4):696-701 2006
Author:Tsutsui M, Ogawa S, Inada Y, Tomioka E, Kamiyoshi A, Tanaka S, Kishida T, Nishiyama M, Murakami M, Kuroda J, Hashikura Y, Miyagawa S, Satoh F, Shibata N, Tagawa Y

Azelnidipine, a long-acting dihydropyridine calcium channel blocker, suppresses the development of cardiac hypertrophy and fibrosis in adrenomedullin knock out mice.
CIRCULATION,114(18):13-13 2006
Author:Shindo T, Niu P, Kamiyoshi A, Sakurai T, Ichikawa Y, Iinuma N, Kawate H

Tea catechin, epigallocatechin-3-gallate, inhibits rubratoxin B-induced apoptosis of hepatocytes through MAPK p38 pathway
Mycotoxins,55(1):17-22 2005
Author:Kagaya N, Kamiyoshi A, Tagawa Y, Nagashima H, Kawase M, Yagi K

Interaction of rubratoxin B with serum albumin
Mycotoxins,55(1):23-26 2005
Author:Kagaya N, Kamiyoshi A, Tagawa Y, Nagashima H, Kawase M, Yagi K

Suppression of cell death in primary rat hepatocytes by a1-acid glycoprotein
J Biosci Bioeng,99(1):81-83 2005
Author:Kagaya N, Kamiyoshi A, Tagawa Y, Akamatsu S, Isoda K, Kawase M, Yagi K

Effect of zinc on hepatoprotectivity of a1-acid glycoprotein
Biomedical Research on Trace Elements,16(4):299-301 2005
Author:Kawase M, Kagaya N, Kamiyoshi A, Tagawa Y, Yagi K

Crucial roles of mesodermal cell lineages in a murine embryonic stem cell-derived in vitro liver organogenesis system
STEM CELLS,23(7):903-913 2005
Author:Ogawa S, Tagawa Y, Kamiyoshi A, Suzuki A, Nakayama J, Hashikura Y, Miyagawa S

Liver organogenesis from murine embryonic stem cells - A substitute system for an animal experiment
HEPATOLOGY,42(4):746A-747A 2005
Author:Ogawa S, Tagawa Y, Kamiyoshi A, Motoyama H, Tsutsui M, Sato F, Nishiyama M, Nakayama J, Hashikura Y, Miyagawa S

Liver protection by bis(maltolato)zinc(II) complex
Exp Anim,53(1):1-9 2004
Author:Kawase M, Kagaya N, Akamatsu S, Kamiyoshi A, Muto S, Tagawa Y, Yagi K

Novel function of rare catechin, epigallocatechin-3-(3"-O-methyl)gallate, against cold injury in primary rat hepatocytes
J Biosci Bioeng,96(6):559-563 2003
Author:Kagaya N, Hara Y, Saijo R, Kamiyoshi A, Tagawa Y, Kawase M, Yagi K

Survival and function of mouse embryonic stem cell-derived cardiomyocytes in ectopic transplants
CARDIOVASCULAR RESEARCH,58(2):435-443 2003
Author:Johkura K, Cui L, Suzuki A, Teng RF, Kamiyoshi A, Okamura S, Kubota S, Zhao X, Asanuma K, Okouchi Y, Ogiwara N, Tagawa Y, Sasaki K

Shinshu University Researcher Directory

Kamiyoshi Akiko

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Kamiyoshi　Akiko