Okumura Nobuo
School of Medicine Department of Health Sciences
Professor
Researcher Information
Research Keyword
- Biomedical Laboratory Sciences, Clinical Laboratory Sciences, Clinical Chemistry, Clinical Immunology, Genetic testing, Thrombosis and Haemostasis
Research activity information
Paper
- Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis
Han Y, Kato M, Ashihara N, Higuchi Y, Matoba H, Wang W, Hayashi H, Itoh Y, Takahashi S, Kurita H, Nakayama J, Okumura N, Hiratsuka S.
Nature Communications., 14(1), 4960, 2023, Refereed
- A novel homozygous variant of the thrombomodulin gene causes a hereditary bleeding disorder
Osada M, Maruyama K, Kokame K, Denda R, Yamazaki K, Kunieda H, Hirao M, Madoiwa S, Okumura N, Murata M, Ikeda Y, Watanabe K, Tsukada Y, Kikuchi T
Blood Advance, 5, 3830-3838, 2021 - A novel variant fibrinogen, AalphaE11del, demonstrating the important of AalphaE11 residue in thrombin binding
Kaido T, Yoda M, Kamijo T, Arai S, Yamauchi K, Okumura N
Int J Hematology, 114, 591-598, 2021 - Novel variant fibrinogen gammap.C352R produced hypodysfibrinogenemia leading to a bleeding episode and failure of infertility treatment
Yoda M, Kaido T, Kamijo T, Taira C, Higuchi Y, Arai S, Okumura N.
Int J Hematology, 114, 325-333, 2021 - Automated screening procedure for phenotype of congenital fibrinogen disorder using novel parameters, |min1|c and Ac/|min1|c obtained from clot waveform analysis of Clauss method
Arai S, Kamijo T, Kaido T, Yoda M, Shinohara S, Suzuki T, Arai N, Sugano M, Uehara T, Okumura N.
CLINICA CHIMICA ACTA, 521, 170-176, 2021 - 28年間で解析した長野県内のフィブリノゲン異常症18家系28例
上條途夢，海藤貴大, 依田将宏, 平千明, 樋口由美子，新井慎平, 竹澤由夏，奥村伸生
長臨技会誌, 10(2), 1-5, 2021 - Recombinant gammaY278H fibrinogen shows normal secretion from CHO cells,
KamijoT, Kaido T, Yoda M, Arai S, Yamauchi K, Okumura N.
Int J Mol Sci, 22, 22:5218; doi:10.3390/ijms22105218, 2021 - Congenital Dysfibrinogenemia Presented with Massive Hematomas Formed after Hysterectomy.
Niwa K, Nagata K, Nakagami T, Shimaoka R, Niwa K, Takenaka M, Tanaka K, Okumura N.
Case Reports in Clinical Medicine, 10, 108-116, 2021 - Screening method for congenital dysfibrinogenemia and hypodysfibrinogenemia using clot waveform analysis with the Clauss method
Arai S, Kamijo T, Hayashi F, Shinohara S, Arai N, Sugano M, Uehara T, Honda T, Okumura N.
Int J Lab Hematol, 43, 281-289, 2021 - Congenital Hypofibrinogenemia in a Neonate with a Novel Mutation in the FGB gene.
Shinozuka J, Okumura N, Nagasawa M, Nishikado M, Kadowaki S, Katsuda I, Imashuku S.
Pediatric Reports, 13, 113-117, 2021 - Changes in serum citrullinated fibrinogen concentration associated with the phase of bacteremia patients
Fujimura S, Higuchi Y, Usami Y, Yamaura M, Higuchi T, Terasawa F, Okumura N.
Clin Chim Acta, 512, 127-134, 2021 - A novel amino acid substitution, fibrinogen Bbetap.Pro234Leu, associated with hypofibrinogenemia causing impairment of fibrinogen assembly and secretion
Kaido T, Yoda M, Kamijo T, Arai S, Taira C, Higuchi Y, Okumura N.
Int. J. Mol. Sci., 21, 9422; doi:10.3390/ijms21249422, 2021 - Acquired dysfibrinogenemia: monoclonal lamda-type IgA binding to fibrinogen caused lower functional plasma fibrinogen level and abnormal clot formation.
Arai S, Kamijo T, Takezawa Y, Sugano M, Nakazawa H, Yanagisawa R, Uehara T, Honda T, Okumura N.
Int J Hematol, 112, 96-104, 2020 - Comparison of molecular structure and fibrin polymerization between two Bbeta-chain N-terminal region fibrinogen variants, Bbetap.G45C and Bbetap.R74C
Kaido T, Yoda M, KamijoT, Taira C, Higuchi Y, Okumura N.
Int J Hematol, 112, 331-340, 2020 - フィブリノゲン低下の著しい重症線溶亢進型DICに認められた2つのフィブリノゲン遺伝子変異
依田 将宏, 海藤 貴大, 上條 途夢, 新井 慎平, 平 千明, 樋口 由美子, 長田 眞, 塚田 唯子, 奥村 伸生． 依田 将宏, 海藤 貴大, 上條 途夢, 新井 慎平, 平 千明, 樋口 由美子, 長田 眞, 塚田 唯子, 奥村 伸生．
臨床病理, 68, 390-397, 2020 - Heterozygous variant fibrinogen γA289V (Kanazawa III) was confirmed as hypodysfibrinogenemia by plasma and recombinant fibrinogens
Takahiro Kaido, Masahiro Yoda, Tomu Kamijo, Chiaki Taira, Yumiko Higuchi, Nobuo Okumura
Int J Lab Hematol, 42, 190-197, 2020
- γD318Y fibrinogen shows no fibrin polymerization due to defective “A-a” and “B-b” interactions, whereas that of γK321E fibrinogen is nearly normal
KamijoT, Mukai S, Taira C, Higuchi Y, Okumura N.
Thromb Res, 182, 150-158, 2019 - Hereditary Fibrinogen Aα-chain amyloidosis in Asia: clinical andmolecular characteristics.
Yazaki M, Yoshinaga T, Sekijima Y, Kametani F, Okumura N.
Int. J. Mol. Sci., 19, 320; doi:10.3390/ijms19010320, 2018 - Fibrin monomers derived from thrombogenic dysfibrinogenemia, Naples-type variant (BβAla68Thr), showed almost entirely normal polymerization
Kamijo T, Nagata K, Taira C, Higuchi Y, Arai S, Okumura N
Thromb Res, 172, 1-3, 2018 - The fibrous form of intracellular inclusion bodies in recombinant variant fibrinogen-producing cells is specific to the hapatic fibrinogen storage disease-inducible variant fibrinogen
Arai S, Ogiwara N, Mukai S, Takezawa Y, Sugano M, Honda T, Okumura N
Int J Hematol, 105, 758-768, 30 Jun. 2017 - Hypodysfibrinogenemia with a heterozygous mutation of γCys326Ser by the novel transversion of TGT to TCT in a patient with pulmonary thromboembolism and right ventricular thrombus
Ushijima A, Komai T, Matsukawa A, Oikawa K, Morita N, Asai S, Mukai S, Okumura N, Kobayashi Y, Miyachi H.
Cardiology(Karger), 137, 167-172, 2017 - A novel frameshift mutation in the fibrinogen γC terminal region, FGG c.1169_1170 del AT, leading to hypofibrinogenemia.
Nagata K, Arai S, Taira C, Sugano M, Honda T, Okumura N,
Thromb Res, 159, 82-85, 2017 - Congenital dysfibrinogenemia in a Japanese family with Fibrinogen Naples (BβAla68Thr) manifesting as superior sagittal sinus thrombosis
Yoshida S, Kibe T, Matsubara R, Koizumi S, Nara K, Amono K, Okumura N.
Blood Coag Fibrinolysis, 28, 580-584, 2017 - A novel mutation in the fibrinogen Bβ chain (c.490G>A; End of Exon 3) causes a splicing abnormality and ultimately leads to congenital hypofibrinogenemia
Taira C, Matsuda K, Arai S, Sugano M, Uehara T, Okumura N.
Int. J. Mol. Sci, 18, 2470(doi:10.3390/ijms18112470), 2017 - Genetic analyses of novel compound heterozygous hypodysfibrinogenemia, Tsukuba I: FGG c.1129+62_65 del AATA and FGG c.1299+4 del A
Mukai S, Nagata K, Ikeda M, Arai S, Sugano M, Honda T, Okumura N
Thromb Res, 148, 111-117, 31 Dec. 2016 - Differences in the function and secretion of congenital aberrant fibrinogenemia between heterozygous gamma D320G (Okayama II) and gamma Delta N319-Delta D320 (Otsu I)
Mukai, S; Ikeda, M; Takezawa, Y; Sugano, M; Honda, T; Okumura, N
THROMBOSIS RESEARCH, 136(6), 1318-1324, Dec. 2015 - Novel heterozygous dysfibrinogenemia, Sumida (A alpha C472S), showed markedly impaired lateral aggregation of protofibrils and mildly lower functional fibrinogen levels
Ikeda, M; Arai, S; Mukai, S; Takezawa, Y; Terasawa, F; Okumura, N
THROMBOSIS RESEARCH, 135(4), 710-717, Apr. 2015 - Recombinant gamma T305A fibrinogen indicates severely impaired fibrin polymerization due to the aberrant function of hole 'a' and calcium binding sites
Ikeda, M; Kobayashi, T; Arai, S; Mukai, S; Takezawa, Y; Terasawa, F; Okumura, N
THROMBOSIS RESEARCH, 134(2), 518-525, Aug. 2014 - γ375W fibrinogen-synthesizing CHO cells indicate the accumulation of variant fibrinogen within endoplasmic reticulum
Kobayashi, T; Arai, S; Ogiwara, N; Takezawa, Y; Nanya, M; Terasawa, F; Okumura, N
THROMBOSIS RESEARCH, 133(1), 101-107, 2014 - Successdul living-related kidney transplantation in a boy with inherited dysfibrinogenemia
Imamura H, Akioka Y, Asano T, Sugawara N, Ishizuka K, Chikamoto H, Taki M, Terasawa F, Okumura N, Hattori M.
Pediatr Transplant, 17, E161- E164, 2013 - Fibrinopeptide A release is necessary for effective B:b interactions in polymerization of variant fibrinogens with impaired A:a interactions
Soya K, Terasawa F, Okumura N
THROMBOSIS AND HAEMOSTASIS, 109, 221-228, 2013 - siRNA down-regulation of FGA mRNA in HepG2 cells demonstratedthat heterozygous abnormality of the Aalfa-chain gene does not affect the plasma fibrinogen level
Takezawa Y, Matsuda K, Terasawa F, Sugano M, Honda T, Okumura N
THROMBOSIS RESEARCH, 131, 342-348, 2013 - Nonsense-mediated mRNA decay was demonstrated in two hypofibrinogenemias caused by heterozygous nonsense mutations of FGG, Shizuoka III and Kanazawa II
Soya K, Takezawa Y, Okumura N, Terasawa F
Thromb Res, 132, 465-470, 2013 - Molecular analysis of afibrinogenemic mutations caused by a homozygous FGA1238 bp deletion, and a compound heterozygous FGA1238 bpdeletion and novel FGA c.54+3A>C substitution
Takezawa, Y; Terasawa, F; Matsuda, K; Sugano, M; Tanaka, A; Fujiwara, M; Kainuma, K; Okumura, N
INTERNATIONAL JOURNAL OF HEMATOLOGY, 96(1), 39-46, Jul. 2012 - Application of allele-specific quantitative PCR using genomic DNA to monitor minimal residual disease based on mutant gene levels following allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies: Comparison of mutant levels with autologousDNA percentage by short tandem repeat-PCR.
Taira C, Matsuda K, Saito S, Sakashita K, Sugano M, Okumura N, Honda T.
CLINICA CHIMICA ACTA, 413, 516-519, 2012 - Lateral medullary syndrome in a boy with hereditary dysfibrinogenemia
Kibe T, Ikeya M. Yokochi K, Okumura N
Brain and Development, 34, 857-860, 2012 - Heterozygous Bβ C-terminal 12 amino acid-elongation variant,BβX462W (Kyoto VI), showed dysfibrinogenemia.
Okumura N , Terasawa F, Takezawa Y, Hirota-Kawadobora M, Inaba T, Fujita N, Saito M, Sugano M, Honda T.
Blood Coagulation and Fibrinolysis, 23(1), 87-90, 2012 - フィブリノゲンの細胞内生成・分泌におけるBβ鎖D領域454-458残基の重要性
寺澤文子, 竹澤由夏, 廣田（川戸洞）雅子, 奥村伸生
臨床病理, 59, 741-748, 2011 - Quantitative monitoring of single nucleotide mutation by allele-specific quantitative PCR can be used for assessment of minimal residual disease in patients with hematological malignancies throughout their clinical course.
Taira C, Matsuda K, Kamijyo Y, Sakashita K, Ishida F, Kumagai T, Yamauchi K, Okumura N, Honda T.
CLINICA CHIMICA ACTA, 412, 53-58, 2011 - Spontaneous regression of the inhibitor against the coagulation factor XIII A subunit in acquired factor XIII deficiency.
Ishida F, Okubo K, Ito T, Okumura N, Souri M, Ichinose A.
THROMBOSIS AND HAEMOSTASIS, 104, 1284-1285, 2010 - In vitro transcription of compound heterozygous hypofibrinogenemia Matsumoto IX; first identification of FGB IVS6 deletion of 4 nucleotides and FGG IVS3-2A>G causing abnormal RNA splicing
Fumiko Terasawa, Yuka Kamijyo, Noriko Fujihara, Kazuyoshi Yamauchi, Toshiko Kumagai, Takayuki Honda, Satoshi Shigematsud and Nobuo Okumura
CLINICA CHIMICA ACTA, 411(17-18), 1325-1329, 2010 - A C-terminal amino acid substitution in the gamma-chain caused by a novel heterozygous frameshift mutation (Fibrinogen Matsumoto VII) results in hypofibrinogenaemia.
Fujihara N, Haneishi A, Yamauchi K, Terasawa F, Ito T, Ishida F, Okumura N.
THROMBOSIS AND HAEMOSTASIS, 104(2), 213-223, 2010 - Impaired protofibril formation in fibrinogen gammaN308K is due to altered D:D and “A:a” interactions.
Bowley SR, Okumura N, Lord ST.
Biochemistry, 48, 8656-8663, 2009 - Citrullinated fibrinogen shows defects in FPA and FPB release and fibrin polymerization catalyzed by thrombin.
Okumura N, Haneishi A, Terasawa F.
CLINICA CHIMICA ACTA, 401, 119-123, 2009, Refereed - Recombinant variant fibrinogens substituted at residues gamma326Cys and gamma339Cys demonstrated markedly impaired secretion of assembled fibrinogen.
HaneishiA, Terasawa F, Fujihara N, Yamauchi K, Okumura N, Katsuyama T.
THROMBOSIS RESEARCH, 124, 368-372, 2009 - Analysis of plasmin generation and clot lysis of plasma fibrinogen purified from a heterozygous dysfibrinogenemia, betaGly15Cys (Hamamatsu II).
Kamijyo Y, Hirota-Kawadobora M, Yamauchi K, Terasawa F, Honda T, Ikeya M, Okumura N.
Blood Coagulation and Fibrinolysis, 20(8), 726-732, 2009 - Sialic acid moiety of apolipoprotein E3 at Thr194affects its ｉｎｔｅｒａｃｔｉｏｎ ｗｉｔｈ ?-ａｍｙｌｏｉｄ1-42 peptides
Sugano M, Yamauchi K, Kawasaki K, Tozuka M, Fujita K, Okumura N, Ota H
CLINICA CHIMICA ACTA, 388, 123-129, 2008 - Polymerization-defective fibrinogen variant gammaD364A binds knob “A” peptide mimic
Bowley SR, Mereｎbloom BK, Okumura N, Betts L, Heroux A, Gorkun OV, Lord ST
Biochemistry, 37, 8607-8613, 2008 - In vitro expression of a-thalassaemia gene (IVS1-1G>C) reveals complete inactivation of the normal 5’splice site and alternative aberrant RNA splicing.
Fujihara N, Yamauchi K, Hirota-Kawadobora M, Ishikawa S, Tozuka M, Ishii E, Katsuyama T, Okumura N, Taniguchi S
ANNALS OF CLINICAL BIOCHEMISTRY, 44, 573-578, 2007 - B:b interactions are essential for polymerization of variant fibrinogens with impaired holes ‘a’
Okumura N, Terasawa F, Haneishi A，Fujihara N，Hirota-Kawadobora M, Yamauchi K, Ota H, Lord ST
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 5, 2352-2359, 2007 - Mechanism of IgA-albumin complex formation that affectsthe fructosamine assay
Fijita K, Kameko F, Kato Y, Fukushima M, Okumura N, Terasawa F, Sugano M, YamauchiK, Sato H, Kameko M, Sakurabayashi I.
Journal of Electrophoresis, 50, 19-23, 2006 - An immunoglobulin A1 that inhibits lactate dehydrogenaseactivity, with reversal of inhibition by addition of NADH
Fujita K, Sato H, Kameko F, Terasawa F, Okumura N, Sugano M, Yamauchi K, Maekawa M, Sakurabayashi I.
ANNALS OF CLINICAL AND LABORATORY SCIENCE, 36, 461-468, 2006 - Co-localization of TFF2 with gland mucouscell mucin in gastric mucous cellsand in extracellular mucous gel adherent to normal and damaged gastric mucosa
Ota, H; Hayama, M; Momose, M; El-Zimaity, HMT; Matsuda, K; Sano, K; Maruta, F; Okumura, N; Katsuyama, T
HISTOCHEMISTRY AND CELL BIOLOGY, 126, 617-625, 2006 - A novel variant fibrinogen, deletion of B beta 111Ser in coiled-coil region, affecting fibrin lateral aggregation
Okumura, N; Terasawa, F; Hirota-Kawadobora, M; Yamauchi, K; Nakanishi, K; Shiga, S; Ichiyama, S; Saito, M; Kawai, M; Nakahata, T
CLINICA CHIMICA ACTA, 365, 160-167, 2006 - Analysis of fibrinogen variants at gamma 387Ile shows that the side chain of gamma 387 and the tertiary structure of the gamma C-terminal tail are important not only for assembly and secretion of fibrinogen but also for lateral aggregation of protofibrils and XIIIa-catalyzed gamma-gamma dimer formation
Kani, S; Terasawa, F; Yamauchi, K; Tozuka, M; Okumura, N
BLOOD, 108, 1887-1894, 2006 - Invitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gAsn319,Asp320 deletion dysfibrinogen, Otsu I.
Terasawa F, Kani S, Hongo M, Okumura N.
THROMBOSIS RESEARCH, 118, 651-661, 2006 - Residue gamma153Cys is essential for the formationof the complexes Aalpha-gamma and Bbeta-gamma, assembly intermediates for the Aalpha-Bbeta-gamma complex and intact fibrinogen
Fumiko Terasawa, Kiyotaka Fujita, Nobuo Okumura
CLINICA CHIMICA ACTA, 353, 157-164, 2005 - Functional analysis of recombinant Bbeta15C and Bbeta15A fibrinogens demonstrates that Bbeta15G residue plays important roles in FPB release and in lateral aggregation of protofibrils
M.Hirota-Kawadobora, S.Kani, F.Terasawa, N.Fujihara, K.Yamauchi, M.Tozuka, N.Okumura
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 3, 983-990, 2005 - In vitro expression demonstrates impaired secretion of the gammaAsn 319, Asp320 deletion variant fibrinogen
Kani S, Terasawa F, Lord ST, Tozuka M, Ota H, Okumura N, Katsuyama T
Thromb Haemost, 94, 53-59, 2005 - Characterization of factor XII Tenri, a rare CRM-negative factor XII deficiency
Noriko Fijihara, Minoru Tozuka, Kazuyoshi Yamauchi, Ichiro Ueno, Nobuyuki Urasawa, Shinsuke Ishikawa, Masako Hirota-Kawadobora, Nobuo Okumura, Hiroya Hidaka, Tsutomu Katsuyama
ANNALS OF CLINICAL AND LABORATORY SCIENCE, 34, 218-225, 2004 - Recombinant fibrinogen, gamma275Arg->Cys, exhibits formation of disulfide bond with cysteine and severely impaired D:D interactions
S.Ishikawa, M.Hirota-Kawadobora, M.Tozuka, K.Ishii, F.Terasawa, N.Okumura
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2, 468-475, 2004 - Substitution of the gamma-chain Asn308 disturbs the D:D interface affecting fibrin polymerization, fibrinopeptide B release, and FXIIIa-catalyzed cross-linking
Nobuo Okumura, Oleg V. Gorkun, Fumiko Terasawa, Susan T. Lord
BLOOD, 103, 4157-4163, 2004 - Comparison of thrombin-catalyzed fibrin polymerization and factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma275C, gamma275H, and gamam275A
M.Hirota-Kawadobora, F.Terasawa, T.Suzuki, M.Tozuka, K.Sano, N.Okumura
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2, 1359-1367, 2004 - Fibrinogens Kosai and Ogasa: Bβ15Gly-Cys(GGT-TGT) substitution associated with impairment of fibrinopeptide B release and lateral aggregation.
Hirota-Kawadobora M, Terasawa F, Yonekawa O, Sahara N, Shimizu E, Okumura N, Katsuyama T, Shigematsu
J Thrombosis and Haemostasis, 1, 275-283, 2003 - Immunohistochemical lacalization of sodium-potassium ATPase in human normal stomach and gastric adenocarcinomas.
Kobayashi C, Hayama M, Harada O, Terasawa F, Okumura N, Sugiyama A, Ota H
Histochem Cell Biol, 119, 317-322, 2003 - Fibrinogen Otsu I: A γAsn319, Asp320 deletiondysfibrinogen identified in an asymotomatic pregnant woman.
Terasawa F, Hogan KA, Kani S, Hirose M, Eguchi Y, Noda Y, Hongo M, Okumura N
THROMBOSIS AND HAEMOSTASIS, 90, 757-758, 2003 - Identification and properties of glycated monoclonal IgA that Affect the fructosamine assay.
Fujita K, Curtiss LK, Sakurabayashi I, Kameko F, Okumura N, Terasawa F, Tozuka M, Katsuyama
CLINICAL CHEMISTRY, 49, 805-808, 2003 - Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats
Hironaka E, Hongo M, Sakai A, Mawatari E, Ushiyama Y, Terasawa F, Okumura N,Yamazaki A, Yazaki Y, Kinoshita O, Kubo
Cardiovascular Research, 60, 692-699, 2003 - Novel beta-thalassemia trait (IVS I-1 G->C) in a Japanese family
Noriko Fijihara, Minoru Tozuka, Ichiro Ueno, Kazuyoshi Yamauchi, Ritsuko Nakagoshi, Shinsuke Ishikawa, Masako Hirota, Nobuo Okumura, Eizaburo Ishii, Tsutomu Katsuyama
American Journal of Hematology, 72, 64-66, 2003 - Sequence gamam377-395(P2), but not gamma190-202(P1),is the binding site for the alphaMI-domain of integrin alphaMbeta2 inthe gammaC-domain of fibrinogen
Tatiana P. Ugarova, Valeryi K. Lishko, Nataly P. Podolnikova, Nobuo Okumura, et al (5)
Biochemistry, 42, 9365-9373, 2003 - The Aalpha-chain 6Ile/Val polymorphism is not associated with plasma fibrinogen levels in Japanese
Fumiko Terasawa, Masako Hirota-Kawadobora, Hikaru Kobayashi, Hiroshi Saito, Minoru Tozuka, Nobuo Okumura
THROMBOSIS RESEARCH, 112, 257-259, 2003 - Predominant apolipoprotein J exists as lipid-poor mixtures in cerebrospinal fluid
Suzuki T, Tozuka M, Kazuyoshi Y, Sugano M, Nakabayashi T, Okumura N, Hidaka H, Katsuyama T, Higuchi K
Ann Clin Lab Sci, 32, 369-376, 2002 - Analysisof fibrinogen gamma-chain truncations shows the C-terminus, particularly gammaIle387, is essential for assembly and secretion of this multichain protein
Okumura N, Terasawa F, Tanaka H, Hirota M, Ota H, Kitano K, Kiyosawa K, Lord ST
BLOOD, 99, 3654-3660, 2002 - Quantitative RT-PCR analysis demonstrates that synthesis of the recombinant fibrinogen is dependent on the transcription and synthesis of g-chain
Hirota-Kawadobora M, Tozuka M, Yamauchi K,Hidaka E, Ueno I, Sugano M, Terasawa F, Okumura N,Katuyama T, Shigematsu H
CLINICA CHIMICA ACTA, 319, 67-73, 2002 - Evidence that heterodimers exist in the fibrinogenMatsumoto II (γ308N-K) proband and participate infibrin fiber formation.
Okumura N, Terasawa F, Kiyotaka Fujita, Noriko Fujiwara, Minoru Tozuka, Chang-Sung Koh
Thrombosis Reseach, 107, 157-162, 2002 - Fibrinogen Matsumoto V: a variant with Aα19 Arg->Gly(AGG->GGG). Comparison between fibrin polymerization stimulated by thrombin or reptilase and fibrin monomer polymerization.
Tanaka H, Terasawa F, Ito T，Tokunaga S, Ishida F, Kitano K, Kiyosawa K, Okumura N
THROMBOSIS AND HAEMOSTASIS, 85, 108-113, 2001 - Polymerization site a function dependence on structural integrity of its nearby calcium binding site.
Lounes KC, Okumura N, Hogan KA, Ping L, Lord ST
Annals of New York Academy of Science, 936, 205-209, 2001 - The formation of β fibrin requires a functional a site.
Hogan KA, Bolliger B, Okumura N, Lord ST
Annals of New York Academy of Science, 936, 219-222, 2001 - Hypofibrinogenemia associated with a heterozygous C->T nucleotide substitution at position -1138 bp of the 5'-flanking region of the fibrinogen Aα-chain.
Okumura N, Terasawa F, Yonekawa O, Hamada E, Kaneko H
Annals of New York Academy of Science, 936, 526-530, 2001 - Difference in electrophoretic mobility and plasmic digestion profile between four recombinant fibrinogens, gamma 308K, gamma 308I, gamma 308A, and wild type (gamma 308N)
Okumura, N; Terasawa, F; Fujita, K; Tozuka, M; Ota, H; Katsuyama, T
Electrophoresis, 21(12), 2309-2315, 2000 - A functional assay suggests that heterodimers exist in two C-terminal γ-chaindysfibrinogens; Matsumoto I and Vlissingen/Frankfurt IV.
Hogan KA, Lord ST, Okumura N, Terasawa F, Galanakis DK, Scharrer I, Gorkun OV
THROMBOSIS AND HAEMOSTASIS, 83(4), 592-597, 2000 - Identification of a dysfibrinogen, the substitution of γ308Asn(AAT) to Lys(AAG), using coagulation tests, immunoblot analysis, and allele-specific polymerase chain reaction.
Terasawa F, Fujita K, Tozuka M, Ota H, Katsuyama T, Okumura N
CLINICA CHIMICA ACTA, 295(1-2), 77-85, 2000 - Analysis of hemoglobin and globin chain variants by a commonly used capillary isoelectric focusing method.
Sugano M, Hidaka H, Yamauchi K, Nakabayahsi T, Higuchi Y, Fujita K, Okumura N, Ushiyama Y, Tozuka M, Katsuyama T
Electrophoresis, 21(14), 3016-3019, 2000 - Comparison of functions between recombinant variant fibrinogens, r308K, r308I and r308A
Okumura, N; Terasawa, F; Lord, ST
THROMBOSIS AND HAEMOSTASIS, 321-321, 1999 - Fibrinogen Matsumoto IV: A heterozygous fibrinogen deficiency caused by a missense mutation ofr153Cys toArg
Terasawa, F; Okumura, N; Lord, ST
THROMBOSIS AND HAEMOSTASIS, 42-42, 1999 - Hypofibrinogenemia associated with a heterozygous missense mutation γ153Cys to Arg (Matsumoto IV): In vitro expression demonstrates defective secretion of the variant fibrinogen.
Terasawa F, Okumura N, Kitano K, Hayashida N, Shimosaka M, Okazaki M, Lord ST
BLOOD, 94(12), 4122-4131, 1999 - Fibrinogen Matsumoto III: a variant with γ275Arg→Cys(CGC→TGC) -comparison of fibrin polymerization with those of Matsumoto I (γ364Asp→His) and Matsumoto II (γ308Asn→Lys).
Terasawa F, Okumura N,Higuchi Y, Ishikawa S, Tozuka M, Kitano K, Katsuyama T
THROMBOSIS AND HAEMOSTASIS, 81(5), 763-766, 1999 - Genetic analyses in homozygous and heterozygous variant of lactate dehydrogenese-B(H) subunit-LD-B Matsumoto I and II (LD-B W323R)-.
Okumura N, Terasawa F, Ueno I, Oki K, Yamauchi K, Hidaka H, Tozuka M, Okura M, Katsuyama T
Clinica Chimica Acta, 287(1-2), 163-171, 1999 - Flow Cytometryを用いた血小板活性化能測定の基礎的検討とその評価法
石川伸介, 戸塚 実, 廣田雅子, 佐々木由美子, 奥村伸生, 降旗謙一, 勝山 努
臨床病理, 46, 605-610, 1998 - PlasminogenKanagawa-I, a novel missense mutation, is caused by the amino acid substitution G732R
Higuchi Yumiko, Furihata Kenichi, Ueno Ichiro, Ishikawa Shinshuke, Okumura Nobuo, Tozuka Minoru, Sakurai Noriko
British J of Haematology, 103(3), 867-870, 1998 - Megakaryocytes derived from CD34-positive cord blood cells produce interleukin-8
Higuchi, T; Koike, K; Sawai, N; Mwamtemi, HH; Takeuchi, K; Shiohara, M; Kikuchi, T; Yasui, K; Ito, S; Yamagami, O; Sasaki, Y; Okumura, N; Kato, T; Miyazaki, H; Ikeda, M; Yamada, M; Komiyama, A
BRITISH JOURNAL OF HAEMATOLOGY, 99(3), 509-516, 1997 - Characterization of hypertriglyceridemia induced by L-asparaginase therapy for acute lymphoblastic leukemia and malignant lymphoma
Tozuka, M; Yamauchi, K; Hidaka, H; Nakabayashi, T; Okumura, NS; Katsuyama, T
ANNALS OF CLINICAL AND LABORATORY SCIENCE, 27(5), 351-357, 1997 - Fibrinogen Matsumoto II: gamma(308)Asn->Lys(AAT->AAG) mutation associated with bleeding tendency
Okumura, N; Furihata, K; Terasawa, F; Ishikawa, S; Ueno, I; Katsuyama, T
BRITISH JOURNAL OF HAEMATOLOGY, 94(3), 526-528, 1996 - A case of immunoglobulin A-lambda conjugated with lactate dehydrogenase-5 isoenzyme, causing an extremely high enzyme activity in serum
Tozuka, M; Hidaka, H; Okumura, N; Ichikawa, T; Furibata, K; Katsuyama, T
CLINICAL CHEMISTRY, 42(8), 1288-1290, 1996 - Fibrinogen Matsumoto I: A gamma 364 Asp->His (GAT->CAT) substitution associated with defective fibrin polymerization
Okumura, N; Furihata, K; Terasawa, F; Nakagoshi, R; Ueno, I; Katsuyama, T
THROMBOSIS AND HAEMOSTASIS, 75(6), 887-891, 1996 - Chemotactic and chemokinetic activities of stem cell factor on murine hematopoietic progenitor cells
Okumura, N; Tsuji, K; Ebihara, Y; Tanaka, I; Sawai, N; Koike, K; Komiyama, A; Nakahata, T
BLOOD, 87(10), 4100-4108, 1996 - Influence of apolipoprotein E phenotypes on total serum cholesterol in Japanese children
Tozuka, M; Ohta, H; Hidaka, H; Okumura, N; Furihata, K; Katsuyama, T
CLINICA CHIMICA ACTA, 247(1-2), 175-180, 1996 - Aberrant growth of granulocyte-macrophage progenitors in juvenile chronic myelogenous leukemia in serum-free culture
Sawai, N; Koike, K; Ito, S; Okumura, N; Kamijo, T; Shiohara, M; Amano, Y; Tsuji, K; Nakahata, T; Oda, M; Okamura, J; Kobayashi, M; Komiyama, A
EXPERIMENTAL HEMATOLOGY, 24(2), 116-122, 1996 - Fibrinogen Matsumoto II: A gamma 308ASN->Lys(AAT->AAG) mutation associated with defective fibrin polymerization.
Okumura, N; Terasawa, F; Ueno, I; Kaysuyama, T; Furihata, K
BLOOD, 86(10), 3520-3520, 1995 - PREVENTION OF HEPATIC-ARTERY THROMBOSIS IN PEDIATRIC LIVER-TRANSPLANTATION
HASHIKURA, Y; KAWASAKI, S; OKUMURA, N; ISHIKAWA, S; MATSUNAMI, H; IKEGAMI, T; NAKAZAWA, Y; MAKUUCHI, M
TRANSPLANTATION, 60(10), 1109-1112, 1995 - GENETIC-ANALYSIS OF FIBRINOGEN MATSUMOTO - A POINT MUTATION IN EXON-9 OF GAMMA-CHAIN RESPONSIBLE FOR DEFECTIVE FIBRIN POLYMERIZATION
TERASAWA, F; OKUMURA, N; UENO, I; HIDAKA, E; FURUWATARI, C; YAN, J; KATSUYAMA, T; FURIHATA, K
BLOOD, 84(10), A60-A60, 1994 - CELL-SURFACE ANTIGEN EXPRESSION IN HUMAN ERYTHROID PROGENITORS - ERYTHROID AND MEGAKARYOCYTIC MARKERS
NAKAHATA, T; OKUMURA, N
LEUKEMIA&LYMPHOMA, 13(5-6), 401-409, 1994 - CHANGES IN CELL-SURFACE ANTIGEN EXPRESSIONS DURING PROLIFERATION AND DIFFERENTIATION OF HUMAN ERYTHROID PROGENITORS
OKUMURA, N; TSUJI, K; NAKAHATA, T
BLOOD, 80(3), 642-650, 1992 - CHANGES IN CELL-SURFACE ANTIGEN EXPRESSIONS DURING PROLIFERATION AND DIFFERENTIATION OF HUMAN ERYTHROID PROGENITORS
OKUMURA, N; NAKAHATA, T
EXPERIMENTAL HEMATOLOGY, 20(6), 793-793, 1992 - INTERLEUKIN-6 SUPPORTS HUMAN MEGAKARYOCYTIC PROLIFERATION AND DIFFERENTIATION INVITRO
IMAI, T; KOIKE, K; KUBO, T; KIKUCHI, T; AMANO, Y; TAKAGI, M; OKUMURA, N; NAKAHATA, T
BLOOD, 78(8), 1969-1974, 1991 - COAGULATION ABNORMALITIES FOLLOWED ORTHOTOPIC LIVING RELATED LIVER-TRANSPLANTATION
SAITO, H; OKUMURA, N; HARADA, H; KUDO, M; MAKUUCHI, M; FURUTA, S
THROMBOSIS AND HAEMOSTASIS, 65(6), 1090-1090, 1991
Affiliated academic society
Research Themes
- 血清中シトルリン化フィブリノーゲン測定による好中球細胞外トラップ検出の検討
科学研究費補助金, 基盤研究（C)
2020 - 2022 - フィブリノゲン機能異常症例の解析からフィブリン重合機序の詳細を解明する研究
科学研究費補助金, 基盤研究（Ｃ）
2017 - 2019 - 肝硬変を引き起こすフィブリノゲン低下症の鑑別法の開発と分子生物学的発生機序解明
科学研究費補助金, 基盤研究Ｃ
2014 - 2016 - 血漿および関節液中のシトルリン化フィブリノゲンとその抗体定量法の確立．
科学研究費補助金, 科学研究費 基盤研究Ｃ
2013 - 2015 - シトルリン化フィブリノゲン・フィブリンの溶解性に関する研究
科学研究費補助金, 基盤（C)
01 Apr. 2010 - 31 Mar. 2012 - シトルリン化フィブリノゲンの凝固・線溶機能異常とその病因との関係
科学研究費補助金, 基盤研究（C）
01 Apr. 2007 - 31 Mar. 2009 - リコンビナントフィブリノゲンを用いたフィブリノゲン-フィブリン転換の分子メカニズムの解析とその正常機能を抑制する合成ペプチドの検索
01 Jan. 2007 - 31 Mar. 2008 - Functional analysis for citrullinated fibrinogen and fibrin
2007 - フィブリノゲンの組み立て・分泌におけるBβ鎖・γ鎖の機能の相違に関する研究
科学研究費補助金, 基盤研究（C）
01 Apr. 2004 - 31 Mar. 2006 - リコンビナントヒト正常・異常フィブリノゲンを用いたフィブリン繊維形成機序の解析と合成ペプチドによるその抑制
01 Apr. 2002 - 31 Mar. 2003 - 異常フィブリノゲンMataumotoIVの遺伝子導入による原因の研究
01 Aug. 1998 - 31 Jul. 1999 - リコンビナント異常フィブリノゲンを用いたフィブリン凝集能の解析
01 Apr. 1997 - 31 Mar. 1998 - Molecular biological research for causes of fibrinogen deficiency
1997 - Functional analysis for dysfibrinogenemia
1993
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