Cardiology, Cardiovascular Medicine, Molecular Cardiology,Cardiovascular Endocrinology and Metabolism

神経体液性因子抑制の新しい展開 : ARNIおよび新世代MRA
桑原 宏一郎
Heart View, 26(1), 68-74, Jan. 2022

Current use of inotropes according to initial blood pressure and peripheral perfusion in the treatment of congestive heart failure: findings from a multicentre observational study
Nagao, Kazuya; Kato, Takao; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Su, Kanae; Kawato, Mitsunori; Seko, Yuta; Inada, Tsukasa; Inoko, Moriaki; Toyofuku, Mamoru; Furukawa, Yutaka; Nakagawa, Yoshihisa; Ando, Kenji; Kadota, Kazushige; Shizuta, Satoshi; Ono, Koh; Sato, Yukihito; Kuwahara, Koichiro; Ozasa, Neiko; Kimura, Takeshi;
BMJ Open, 12(1), e053254, Jan. 2022

Gigantic Pacemaker Pocket Abscess Infected by Staphylococcus epidermidis
Okano T, Okada A, Shoda M, Kuwahara K
Intern Med, 61(4), 593-594, 2022

Effects of cardiac surgical support on long‑term outcomes of emergent or complex percutaneous coronary intervention cases: a sub‑analysis of the SHINANO 5‑year registry
Nakamura C, Ebisawa S, Miura T, Nomi H, Kanzaki Y, Yui H, Maruyama S, Nagae A, Ueki Y, Sakai T, Kato T, Saigusa T, Okada A, Motoki H, Kuwahara K
Heart Vessels, 37(7), 1106-1114, 2022

Comparison of prognostic impact of anticoagulants in heart failure patients with atrial fibrillation and renal dysfunction: direct oral anticoagulants versus vitamin K antagonists
Sakai T, Motoki H, Fuchida A, Takeuchi T, Otagiri K, Kanai M, Kimura K, Minamisawa M, Yoshie K, Saigusa T, Ebisawa S, Okada A, Kitabayashi H, Kuwahara K
Heart Vessels, 37(7), 1232-1241, 2022

Successful endovascular treatment with a stent graft for chronic deep vein thrombosis with multiple arteriovenous fstulas: a case report
Kato T, Fuke M, Nagai F, Nomi H, Kanzaki Y, Yui H, Maruyama S, Nagae A, Sakai T, Saigusa T, Ebisawa S, Okada A, Motoki H, Kuwahara K
J Med Case Rep, 16(1), 257, 2022

Cilostazol effectiveness in reducing drugcoated stent restenosis in the superficial femoral artery: The ZERO study
Miura T, Miyashita Y, Hozawa K, Doijiri T, Kato T, Hayakawa N, Hashizume N, Nakano M, Ikeda U, Kuwahara K, on behalf of the ZERO Investigators
PLOS ONE, 17(7), e0270992, 2022

Usefulness of the controlled-rotation dilator sheath “Evolution RL” for extraction of old leads in two Japanese centers – An experience in use
Tabata H, Okada A, Kobayashi H, Shoin W, Okano T, Higuchi S, Yagishita D, Ebisawa S, Motoki H, Shoda M, Kuwahara K
J Cardiol, 80(4), 339-343, 2022

Gender diference in heart failure with preserved ejection fraction:clinical profles, examinations, and prognosis
Sakai T, Motoki H, Suzuki S, Fuchida A, Takeuchi T, Otagiri K, Kanai M, Kimura K, Minamisawa M, Yoshie K, Saigusa T, Ebisawa S, Okada A, Kitabayashi H, Kuwahara K
Heart Vessels, 37(10), 1710-1718, 2022

The Impact of Hyperuricemia on Patients With Low Body Mass Index After Endovascular Treatments: Data From the I-PAD Registry
Nagae A, Ebisawa S, Saigusa T, Nishikawa K, Fujimori K, Yui H, Maruyama S, Nakamura C, Kashiwagi D, Kobayashi H, Sakai T, Senda K, Kato T, Miura T, Okada A, Motoki H, Kuwahara K
Angiology, 73(8), 753-763, 2022

Intensive exercise therapy for restenosis after superficial femoral artery stenting: the REASON randomized clinical trial
Kato T, Miura T, Yamamoto S, Miyashita Y, Hashizume N, Shoin K, Sasaki S, Kanzaki Y, Yui H, Maruyama S, Nagae A, Sakai T, Saigusa T, Ebisawa S, Okada A, Motoki H, Ikeda U, Kuwahara K; REASON Investigators
Heart Vessels, 37(9), 1596-1603, 2022

Impact of Frailty and Age on Clinical Outcomes in Patients Who Underwent Endovascular Therapy
Nishikawa K, Ebisawa S, Miura T, Kato T, Kanzaki Y, Abe N, Yokota D, Yanagisawa T, Senda K, Wakabayashi T, Oyama Y, Karube K, Itagaki T, Yui H, Maruyama S, Nagae A, Sakai T, Okina Y, Nakazawa S, Tsukada S, Saigusa T, Okada A, Motoki H, Kagoshima M, Kuwahara K
J Endovasc Ther, 29(6), 845-854, 2022

Infective endocarditis caused by Streptococcus pneumoniae from sinusitis: A case report
Yamazaki K, Miura T, Sunohara D, Komatsu T, Mochidome T, Kasai T, Ikeda U, Kuwahara K
J Cardiol Cases, 25(5), 279-281, 2022

NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis
Inazumi H, Kuwahara K, Nakagawa Y, Kuwabara Y, Numaga-Tomita T, Kashihara T, Nakada T, Kurebayashi N, Oya M, Nonaka M, Sugihara M, Kinoshita H, Moriuchi K, Yanagisawa H, Nishikimi T, Motoki H, Yamada M, Morimoto S, Otsu K, Mortensen RM, Nakao K, Kimura T
Circ Res, 130(2), 234-248, 2022

Coronary angiography in patients with acute heart failure: from the KCHF registry
Seko Y, Kishimori T, Kato T, Morimoto T, Yaku H, Inuzuka Y, Tamaki Y, Ozasa N, Shiba M, Yamamoto E, Yoshikawa Y, Yamashita Y, Kitai T, Taniguchi R, Iguchi M, Nagao K, Kawai T, Komasa A, Nishikawa R, Kawase Y, Morinaga T, Toyofuku M, Furukawa Y, Ando K, Kadota K, Sato Y, Kuwahara K, Kimura T; KCHF Study Investigators
ESC Heart Fail, 9(1), 531-544, 2022

Insomnia in patients with acute heart failure: from the KCHF registry
Seko Y, Yamamoto E, Kato T, Morimoto T, Yaku H, Inuzuka Y, Tamaki Y, Ozasa N, Shiba M, Yoshikawa Y, Yamashita Y, Kitai T, Taniguchi R, Iguchi M, Nagao K, Kawai T, Komasa A, Nishikawa R, Kawase Y, Morinaga T, Toyofuku M, Furukawa Y, Ando K, Kadota K, Sato Y, Kuwahara K, Kimura T; KCHF Study Investigators
ESC Heart Fail, 9(5), 2988-2996, 2022

Changes in BNP levels from discharge to 6-month visit predict subsequent outcomes in patients with acute heart failure
Shiba M, Kato T, Morimoto T, Yaku H, Inuzuka Y, Tamaki Y, Ozasa N, Seko Y, Yamamoto E, Yoshikawa Y, Kitai T, Yamashita Y, Iguchi M, Nagao K, Kawase Y, Morinaga T, Toyofuku M, Furukawa Y, Ando K, Kadota K, Sato Y, Nakagawa Y, Kuwahara K, Kimura T
PLOS ONE, 17(1), e0263165, 2022

Left atrial reverse remodeling improves risk stratification in patients with heart failure with recovered ejection fraction
Shiba M, Kato T, Morimoto T, Yaku H, Inuzuka Y, Tamaki Y, Ozasa N, Seko Y, Yamamoto E, Yoshikawa Y, Kitai T, Yamashita Y, Iguchi M, Nagao K, Kawase Y, Morinaga T, Toyofuku M, Furukawa Y, Ando K, Kadota K, Sato Y, Kuwahara K, Kimura T
Sci Rep, 12(1), 4473, 2022

Current use of inotropes according to initial blood pressure and peripheral perfusion in the treatment of congestive heart failure: findings from a multicentre observational study
Nagao K, Kato T, Yaku H, Morimoto T, Inuzuka Y, Tamaki Y, Yamamoto E, Yoshikawa Y, Kitai T, Taniguchi R, Iguchi M, Kato M, Takahashi M, Jinnai T, Ikeda T, Kawai T, Komasa A, Nishikawa R, Kawase Y, Morinaga T, Su K, Kawato M, Seko Y, Inada T, Inoko M, Toyofuku M, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Shizuta S, Ono K, Sato Y, Kuwahara K, Ozasa N, Kimura T
BMJ Open, 12(1), e053254, 2022

Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors
Oda S, Nishiyama K, Furumoto Y, Yamaguchi Y, Nishimura A, Tang X, Kato Y, Numaga-Tomita T, Kaneko T, Mangmool S, Kuroda T, Okubo R, Sanbo M, Hirabayashi M, Sato Y, Nakagawa Y, Kuwahara K, Nagata R, Iribe G, Mori Y, Nishida M
Nat Commun, 13(1), 6374, 2022

NRSF/REST-Mediated Epigenomic Regulation in the Heart: Transcriptional Control of Natriuretic Peptides and Beyond
Inazumi H, Kuwahara K
Biology, 11(8), 1197, 2022

Appetite loss at discharge from acute decompensated heart failure: Observation from KCHF registry
Yamamoto E, Kato T, Yaku H, Morimoto T, Inuzuka Y, Tamaki Y, Ozasa N, Yoshikawa Y, Kitai T, Taniguchi R, Iguchi M, Kato M, Takahashi M, Jinnai T, Ikeda T, Nagao K, Kawai T, Komasa A, Nishikawa R, Kawase Y, Morinaga T, Kawato M, Seko Y, Shiba M, Toyofuku M, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Shizuta S, Ono K, Sato Y, Kuwahara K, Kimura T
PLOS ONE, 17(5), e0267327, 2022

Public assistance in patients with acute heart failure: a report from the KCHF registry
Nishimoto Y, Kato T, Morimoto T, Taniguchi R, Yaku H, Inuzuka Y, Tamaki Y, Yamamoto E, Yoshikawa Y, Kitai T, Iguchi M, Kato M, Takahashi M, Jinnai T, Ikeda T, Nagao K, Kawai T, Komasa A, Nishikawa R, Kawase Y, Morinaga T, Su K, Kawato M, Seko Y, Inoko M, Toyofuku M, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Shizuta S, Ono K, Kuwahara K, Ozasa N, Sato Y, Kimura T
ESC Heart Fail, 9(3), 1920-1930, 2022

Therapeutic angiogenesis for patients with no-option critical limb ischemia by adipose-derived regenerative cells: TACT-ADRC multicenter trial
Shimizu Y, Kondo K, Hayashida R, Sasaki KI, Ohtsuka M, Fukumoto Y, Takashima S, Inoue O, Usui S, Takamura M, Sakuma M, Inoue T, Nagata T, Akashi YJ, Yamada Y, Kato T, Kuwahara K, Tateno K, Kobayashi Y, Shibata R, Murohara T; TACT-ADRC multicenter trial Group
Angiogenesis, 25(4), 535-546, 2022

Starting Neurohormonal Antagonists in Patients With Acute Heart Failure With Mid-Range and Preserved Ejection Fraction
Seko Y, Kato T, Morimoto T, Yaku H, Inuzuka Y, Tamaki Y, Ozasa N, Shiba M, Yamamoto E, Yoshikawa Y, Yamashita Y, Kitai T, Taniguchi R, Iguchi M, Nagao K, Kawai T, Komasa A, Nishikawa R, Kawase Y, Morinaga T, Toyofuku M, Furukawa Y, Ando K, Kadota K, Sato Y, Kuwahara K, Kimura T; KCHF Study Investigators
Circ J, 86(10), 1547-1558, 2022

Prevention of Contrast-Induced Nephropathy After Cardiovascular Catheterization and Intervention With High-Dose Strong Statin Therapy in Japan - The PREVENT CINC-J Study
Watanabe M, Aonuma K, Murohara T, Okumura Y, Morimoto T, Okada S, Nakamura S, Uemura S, Kuwahara K, Takayama T, Doi N, Nakajima T, Horii M, Ishigami K, Nomoto K, Abe D, Oiwa K, Tanaka K, Koyama T, Sato A, Ueda T, Soeda T, Saito Y; PREVENT CINC-J Investigators
Circ J, 86(9), 1455-1463, 2022

Status of adult outpatients with congenital heart disease in Japan: The Japanese Network of Cardiovascular Departments for Adult Congenital Heart Disease Registry
Yao A, Inuzuka R, Mizuno A, Iwano H, Tatebe S, Tsukamoto Y, Sakamoto I, Watanabe H, Fukuda N, Takechi F, Adachi S, Akazawa Y, Kuwahara K, Dohi K, Ishizu T, Miyake M, Koitabashi N, Hasegawa-Tamba S, Sato S, Fujii T, Ehara E, Minamino T, Yamada H, Yamashita E, Kawamatsu N, Masuda K, Soma K, Shiraishi I, Nagai R, Niwa K; JNCVD-ACHD investigators
J Cardiol, 80(6), 525-531, 2022

Body composition and mortality in patients undergoing endovascular treatment for peripheral artery disease
Itagaki, Tadashi; Ebisawa, Soichiro; Otagiri, Kyuhachi; Kato, Tamon; Miura, Takashi; Kanzaki, Yusuke; Abe, Naoyuki; Yokota, Daisuke; Yanagisawa, Takashi; Senda, Keisuke; Okina, Yoshiteru; Wakabayashi, Tadamasa; Oyama, Yushi; Karube, Kenichi; Machida, Keisuke; Takeuchi, Takahiro; Saigusa, Tatsuya; Motoki, Hirohiko; Kitabayashi, Hiroshi; Kuwahara, Koichiro;
Heart and Vessels, 36(12), 1830-1840, Dec. 2021

Relationship between the flood disaster caused by the Reiwa first year east Japan typhoon and cardiovascular and cerebrovascular events in Nagano City: The SAVE trial
Sunohara, Daisuke; Miura, Takashi; Komatsu, Toshinori; Hashizume, Naoto; Momose, Tomoyasu; Kono, Tsunesuke; Motoki, Hirohiko; Mochidome, Tomoaki; Kasai, Toshio; Kuwahara, Koichiro; Ikeda, Uichi;
Journal of cardiology, 78(5), 447-455, Nov. 2021

The natriuretic peptide system in heart failure: Diagnostic and therapeutic implications
Kuwahara, Koichiro;
PHARMACOLOGY & THERAPEUTICS, 227, 107863, Nov. 2021

Prognostic ability of mid-term worsening renal function after percutaneous coronary intervention: findings from the SHINANO registry
Okina, Yoshiteru; Miura, Takashi; Senda, Keisuke; Taki, Minami; Kobayashi, Masanori; Kanai, Masafumi; Okuma, Yukari; Yanagisawa, Takashi; Hashizume, Naoto; Otagiri, Kyuhachi; Shoin, Kyoko; Watanabe, Noboru; Ebisawa, Soichiro; Karube, Kenichi; Nakajima, Hiroyuki; Saigusa, Tatsuya; Miyashita, Yusuke; Kashiwagi, Daisuke; Machida, Keisuke; Abe, Naoyuki; Tachibana, Takahiro; Kanzaki, Yusuke; Maruyama, Takuya; Nomi, Hidetomo; Sakai, Takahiro; Yui, Hisanori; Mochidome, Tomoaki; Kobayashi, Takahiro; Kasai, Toshio; Ikeda, Uichi; Kuwahara, Koichiro;
Heart and Vessels, 36(10), 1496-1505, Oct. 2021

Percutaneous Removal of a Displaced Inferior Vena Cava Filter Using a Loop-Wire Technique and Lead-Extraction Sheaths
Fujimori, Koki; Okada, Ayako; Tabata, Hiroaki; Shoda, Morio; Kuwahara, Koichiro;
CIRCULATION JOURNAL, 85(8), 1403-1403, Aug. 2021

Association between Inter-atrial Septum Motion and Persistent Atrial Fibrillation Recurrence after Catheter Ablation
Kobayashi Hideki, Okada Ayako, Tabata Hiroaki, Shoin Wataru, Okano Takahiro, Yoshie Koji, Oguchi Yasutaka, Kato Ken, Motoki Hirohiko, Shoda Morio, Kuwahara Koichiro
The Shinshu Medical Journal, 69(4), 189-201, Aug. 2021

Prognostic significance of diastolic blood pressure in patients with heart failure with preserved ejection fraction
Fuchida, Aya; Suzuki, Sho; Motoki, Hirohiko; Kanzaki, Yusuke; Maruyama, Takuya; Hashizume, Naoto; Kozuka, Ayako; Yahikozawa, Kumiko; Kuwahara, Koichiro;
Heart and Vessels, 36(8), 1159-1165, Aug. 2021

A decrease in tricuspid regurgitation pressure gradient associates with favorable outcome in patients with heart failure
Seko, Yuta; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Shiba, Masayuki; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Yamashita, Yugo; Iguchi, Moritake; Nagao, Kazuya; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi; KCHF Study Investigators;
ESC HEART FAILURE, 8(4), 2826-2836, Aug. 2021

Multisystem Inflammatory Syndrome in Children - A New Syndrome Complicated With Acute Heart Failure Following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection -
Uchida, Momoko; Kashima, Yuichiro; Mochizuki, Katsunori; Sakamoto, Hiroto; Mori, Kotaro; Ebisawa, Soichiro; Takeshige, Kanako; Nitta, Kenichi; Kuwahara, Koichiro; Imamura, Hiroshi;
CIRCULATION JOURNAL, 85(6), 948-952, Jun. 2021

Safe and effective transvenous lead extraction for elderly patients utilizing non-laser and laser tools: a single-center experience in Japan
Okada, Ayako; Tabata, Hiroaki; Shoda, Morio; Shoin, Wataru; Kobayashi, Hideki; Okano, Takahiro; Yoshie, Koji; Kato, Ken; Saigusa, Tatsuya; Ebisawa, Soichiro; Motoki, Hirohiko; Kuwahara, Koichiro;
Heart and Vessels, 36(6), 882-889, Jun. 2021

第三世代ミネラルコルチコイド受容体拮抗薬(MRA) (特集 新規心不全治療薬の使い方)
桑原 宏一郎;クワハラ コウイチロウ
医学のあゆみ, 277(4), 281-284, 24 Apr. 2021

心筋胎児型遺伝子発現調節経路 (特集 ナトリウム利尿ペプチドに関する話題)
桑原 宏一郎;クワハラ コウイチロウ
循環器内科 = Cardioangiology / 循環器内科編集委員会 編, 89(4), 375-378, Apr. 2021

Serum cholinesterase as a prognostic biomarker for acute heart failure
Shiba, Masayuki; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Seko, Yuta; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Yamashita, Yugo; Iguchi, Moritake; Nagao, Kazuya; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE, 10(3), 335-342, Mar. 2021

Searching for the Frequency of Cardiac Transthyretin Amyloidosis among Elderly Heart Failure Patients Noninvasively Using 99mTc-labeled Pyrophosphate Scintigraphy
Miura, Takashi; Okina, Yoshiteru ; Mochidome, Tomoaki; Kobayashi, Takahiro; Kasai, Toshio; Ikeda, Uichi; Ezawa, Naoki; Sekijima, Yoshiki; Kuwahara, Koichiro
The Shinshu Medical Journal, 69(1), 37-44, 10 Feb. 2021

KCHF Study InvestigatorsSex differences in patients with acute decompensated heart failure in Japan: observation from the KCHF registry (vol 7, pg 2485, 2020)
Yamamoto, Erika; Kato, Takao; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Yoshikawa, Yusuke; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Himura, Yoshihiro; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Kawato, Mitsunori; Seko, Yuta; Toyofuku, Mamoru; Furukawa, Yutaka; Nakagawa, Yoshihisa; Ando, Kenji; Kadota, Kazushige; Shizuta, Satoshi; Ono, Koh; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi; KCHF Study Investigators;
ESC HEART FAILURE, 8(1), 784-784, Feb. 2021

Prognostic usefulness of residual SYNTAX score combined with clinical factors for patients with acute coronary syndrome who underwent percutaneous coronary intervention from the SHINANO Registry
Kashiwagi, Daisuke; Ebisawa, Soichiro; Yui, Hisanori; Maruyama, Shusaku; Nagae, Ayumu; Sakai, Takahiro; Kato, Tamon; Saigusa, Tatsuya; Okada, Ayako; Motoki, Hirohiko; Kuwahara, Koichiro;
Heart and Vessels, 36(2), 170-179, Feb. 2021

Visualization of Spatially-Controlled Vasospasm by Sympathetic Nerve-Mediated ROCK Activation
Imanishi, Ayako; Ichise, Hiroshi; Fan, Chuyun; Nakagawa, Yasuaki; Kuwahara, Koichiro; Sumiyama, Kenta; Matsuda, Michiyuki; Terai, Kenta;
AMERICAN JOURNAL OF PATHOLOGY, 191(1), 194-203, Jan. 2021

"Alpha"-Looped Broken Pacemaker Lead Inside the Heart
Tabata, Hiroaki; Okada, Ayako; Kobayashi, Hideki; Shoin, Wataru; Okano, Takahiro; Yoshie, Koji; Motoki, Hirohiko; Shoda, Morio; Kuwahara, Koichiro;
CIRCULATION JOURNAL, 85(1), 77-77, Jan. 2021

Impact of nutritional index on long-term outcomes of elderly patients with coronary artery disease: sub-analysis of the SHINANO 5 year registry
Maruyama, Shusaku; Ebisawa, Souichiro; Miura, Takashi; Yui, Hisanori; Kashiwagi, Daisuke; Nagae, Ayumu; Sakai, Takahiro; Kato, Tamon; Saigusa, Tatsuya; Okada, Ayako; Motoki, Hirohiko; Kuwahara, Koichiro;
Heart and Vessels, 36(1), 7-13, Jan. 2021

Influence of Worsening Heart Failure During Hospitalization on the Prognosis in Patients with Acute Decompensated Heart Failure
Yamamoto, Erika; Kato, Takao; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;
Circulation, 144, 2021

Inflammation-based assessment for the risk stratification of mortality in patients with heart failure
Itagaki, Tadashi; Motoki, Hirohiko; Otagiri, Kyuhachi; Machida, Keisuke; Takeuchi, Takahiro; Kanai, Masafumi; Kimura, Kazuhiro; Higuchi, Satoko; Minamisawa, Masatoshi; Kitabayashi, Hiroshi; Kuwahara, Koichiro;
SCIENTIFIC REPORTS, 11(1), 14989, 2021

Leadless cardiac pacemaker implantations after infected pacemaker system removals in octogenarians
Higuchi, Satoshi; Okada, Ayako; Shoda, Morio; Yagishita, Daigo; Saito, Satoshi; Kanai, Miwa; Kataoka, Shohei; Yazaki, Kyoichiro; Tabata, Hiroaki; Kobayashi, Hideki; Shoin, Wataru; Okano, Takahiro; Yoshie, Koji; Ejima, Koichiro; Kuwahara, Koichiro; Hagiwara, Nobuhisa;
JOURNAL OF GERIATRIC CARDIOLOGY, 18(7), 505-513, 2021

Admission systolic blood pressure as a prognostic predictor of acute decompensated heart failure: A report from the KCHF registry
Kawase, Yuichi; Kato, Takao; Morimoto, Takeshi; Hata, Reo; Murai, Ryosuke; Tada, Takeshi; Katoh, Harumi; Kadota, Kazushige; Yamamoto, Erika; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Yoshikawa, Yusuke; Iguchi, Moritake; Nagao, Kazuya; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;
PLOS ONE, 16(7), e0253999, 2021

Predictive Value of Abdominal Fat Distribution on Coronary Artery Disease Severity Stratified by Computed Tomography-Derived SYNTAX Score
Otagiri, Kyuhachi; Machida, Keisuke; Itagaki, Tadashi; Takeuchi, Takahiro; Tsujinaka, Yusuke; Yui, Hisanori; Nakamura, Chie; Sakai, Takahiro; Kato, Tamon; Saigusa, Tatsuya; Ebisawa, Soichiro; Motoki, Hirohiko; Kuwahara, Koichiro; Kitabayashi, Hiroshi;
AMERICAN JOURNAL OF CARDIOLOGY, 150, 32-39, 2021

Absolute quantitative analysis of cardiac amyloidosis using SPECT/CT with Tc-99m-pyrophosphate
Yanagisawa, Shin; Takahashi, Yusuke; Sasaki, Jun; Takasone, Ken; Yoshie, Koji; Koyama, Jun; Katoh, Nagaaki; Yazaki, Masahide; Kuwahara, Koichiro; Fujinaga, Yasunari; Sekijima, Yoshiki;
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 28(3), 213-214, 2021

Protocol: Prospective observational study investigating the prevalence and clinical outcome of portopulmonary hypertension in Japanese patients with chronic liver disease
Wakabayashi, Shun-ichi; Joshita, Satoru; Kimura, Kazuhiro; Motoki, Hirohiko; Kobayashi, Hiroyuki; Yamashita, Yuki; Sugiura, Ayumi; Yamazaki, Tomoo; Kuwahara, Koichiro; Umemura, Takeji;
PLOS ONE, 16(4), 2021

Lower In-Hospital Mortality With Beta-Blocker Use at Admission in Patients With Acute Decompensated Heart Failure
Tamaki, Yodo; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Ozasa, Neiko; Yamamoto, Erika; Yoshikawa, Yusuke; Miyake, Makoto; Kondo, Hirokazu; Tamura, Toshihiro; Kitai, Takeshi; Iguchi, Moritake; Nagao, Kazuya; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Kawato, Mitsunori; Toyofuku, Mamoru; Sato, Yukihito; Kuwahara, Koichiro; Nakagawa, Yoshihisa; Kato, Takao; Kimura, Takeshi; KCHF Study Investigators;
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(13), 2021

A case of transient ventricular pre-excitation associated with takotsubo cardiomyopathy
Kobayashi, Hideki; Tabata, Hiroaki; Shoin, Wataru; Okano, Takahiro; Yoshie, Koji; Okada, Ayako; Shoda, Morio; Kuwahara, Koichiro;
JOURNAL OF ELECTROCARDIOLOGY, 65, 73-75, 2021

Association of the Prognosis of Ankle-brachial Index Improvement One Year Following Endovascular Therapy in Patients with Peripheral Artery Disease: Data from the I-PAD NAGANO Registry
Senda, Keisuke; Miura, Takashi; Kato, Tamon; Kanzaki, Yusuke; Abe, Naoyuki; Yokota, Daisuke; Yanagisawa, Takashi; Okina, Yoshiteru; Wakabayashi, Tadamasa; Oyama, Yushi; Karube, Kenichi; Itagaki, Tadashi; Yoda, Hidetsugu; Shoin, Kyoko; Oguchi, Yasutaka; Aizawa, Katsuyuki; Suzuki, Chihiro; Kuwahara, Koichiro; I-PAD NAGANO Registry Investigator;
INTERNAL MEDICINE, 60(13), 1999-2006, 2021

Prognostic value of reduction in left atrial size during a follow-up of heart failure: an observational study
Shiba, Masayuki; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Seko, Yuta; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Yamashita, Yugo; Iguchi, Moritake; Nagao, Kazuya; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi; KCHF Study Investigators;
BMJ Open, 11(2), e044409, 2021

Impact of Frailty and Age on Clinical Outcomes in Patients Who Underwent Endovascular Therapy
Nishikawa, Ken; Ebisawa, Soichiro; Miura, Takashi; Kato, Tamon; Yusuke, Kanzaki; Abe, Naoyuki; Yokota, Daisuke; Yanagisawa, Takashi; Senda, Keisuke; Wakabayashi, Tadamasa; Oyama, Yushi; Karube, Kenichi; Itagaki, Tadashi; Yui, Hisanori; Maruyama, Shusaku; Nagae, Ayumu; Sakai, Takahiro; Okina, Yoshiteru; Nakazawa, Shun; Tsukada, Shunichi; Saigusa, Tatsuya; Okada, Ayako; Motoki, Hirohiko; Kagoshima, Mitsuru; Kuwahara, Koichiro;
JOURNAL OF ENDOVASCULAR THERAPY, 29(6), 15266028211067728, 2021

Ischemic Stroke in Acute Decompensated Heart Failure: From the KCHF Registry
Iguchi, Moritake; Kato, Takao; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Hamatani, Yasuhiro; Yamashita, Yugo; Masunaga, Nobutoyo; Ogawa, Hisashi; Ishii, Mitsuru; An, Yoshimori; Taniguchi, Ryoji; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Kawato, Mitsunori; Seko, Yuta; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Abe, Mitsuru; Akao, Masaharu; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(21), e022525, 2021

Improved and new-onset anemia during follow-up in patients with acute decompensated heart failure Characteristics and outcomes
Seko, Yuta; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Shiba, Masayuki; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Yamashita, Yugo; Iguchi, Moritake; Nagao, Kazuya; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi; KCHF Study Investigators;
MEDICINE, 100(32), e26892, 2021

Newly Diagnosed Infection After Admission for Acute Heart Failure: From the KCHF Registry
Seko, Yuta; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Shiba, Masayuki; Yamamoto, Erika; Yoshikawa, Yusuke; Yamashita, Yugo; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Nagao, Kazuya; Jinnai, Toshikazu; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi; KCHF Study Investigators;
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(22), e023256, 2021

Risk Factors and Clinical Outcomes of Nonhome Discharge in Patients With Acute Decompensated Heart Failure: An Observational Study
Washida, Koichi; Kato, Takao; Ozasa, Neiko; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Seko, Yuta; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Yamashita, Yugo; Iguchi, Moritake; Nagao, Kazuya; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(15), e020292, 2021

Current Status of Heart Failure Drug Ttreatment
KUWAHARA Koichiro
The Shinshu Medical Journal, 68(6), 349-355, Dec. 2020

Impact of changes in body mass index after percutaneous coronary intervention on long-term outcomes in patients with coronary artery disease
Yui, Hisanori; Ebisawa, Soichiro; Miura, Takashi; Nakamura, Chie; Maruyama, Shusaku; Kashiwagi, Daisuke; Nagae, Ayumu; Sakai, Takahiro; Kato, Tamon; Saigusa, Tatsuya; Okada, Ayako; Motoki, Hirohiko; Kuwahara, Koichiro;
Heart and Vessels, 35(12), 1657-1663, Dec. 2020

Prognostic impact of mineralocorticoid receptor antagonist in patients with heart failure with preserved ejection fraction
Suzuki, Sho; Motoki, Hirohiko; Kanzaki, Yusuke; Maruyama, Takuya; Hashizume, Naoto; Kozuka, Ayako; Yahikozawa, Kumiko; Kuwahara, Koichiro;
ESC HEART FAILURE, 7(5), 2752-2761, Oct. 2020

Rationale and design of the EMPYREAN study
Motoki, Hirohiko; Masuda, Izuru; Yasuno, Shinji; Oba, Koji; Shoin, Wataru; Usami, Satoru; Saito, Yoshihiko; Waki, Masako; Komatsu, Mitsuhisa; Ueshima, Kenji; Nakagawa, Yasuaki; Son, Cheol; Yonemitsu, Shin; Hiramitsu, Shinya; Konda, Manako; Onishi, Katsuya; Kuwahara, Koichiro;
ESC HEART FAILURE, 7(5), 3134-3141, Oct. 2020

Sex differences in patients with acute decompensated heart failure in Japan: observation from the KCHF registry
Yamamoto, Erika; Kato, Takao; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Himura, Yoshihiro; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Kawato, Mitsunori; Seko, Yuta; Toyofuku, Mamoru; Furukawa, Yutaka; Nakagawa, Yoshihisa; Ando, Kenji; Kadota, Kazushige; Shizuta, Satoshi; Ono, Koh; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi; KCHF Study Investigators;
ESC HEART FAILURE, 7(5), 2485-2493, Oct. 2020

Sodium-Glucose Cotransporter-2 inhibitors are potential therapeutic agents for treatment of non-diabetic heart failure patients
Nakagawa, Yasuaki; Kuwahara, Koichiro;
Journal of cardiology, 76(2), 123-131, Aug. 2020

Prognostic significance of resting heart rate in atrial fibrillation patients with heart failure with reduced ejection fraction
Suzuki, Sho; Motoki, Hirohiko; Kanzaki, Yusuke; Maruyama, Takuya; Hashizume, Naoto; Kozuka, Ayako; Yahikozawa, Kumiko; Kuwahara, Koichiro;
Heart and Vessels, 35(8), 1109-1115, Aug. 2020

Impact of Ambulation Status in Patients with End-stage Renal Disease on Hemodialysis due to Diabetic Nephropathy : The PREDICT Study
Kato T, Miyashita Y, Sone H, Mizukami T, Kanno Y, Oguchi T, Yokota D, Shiotsuki N, Mizukami E, Terashima M, Aruga M, Yui H, Maruyama S, Kobayashi H, Kashiwagi D, Nagae A, Sakai T, Saigusa T, Ebisawa S, Okada A, Motoki H, Kuwahara K
The Shinshu Medical Journal, 68(3), 131-138, 10 Jun. 2020

Prognostic Impact of Cardio-renal-anemia Syndrome in Patients at Risk for Heart Failure from the IMPACT-ABI study
Shoin W, Ebisawa S, Saigusa T, Sakai T, Oguchi Y, Okada A, Motoki H, Kuwahara K
The Shinshu Medical Journal, 68(3), 139-147, 10 Jun. 2020

A Predictive Model for 6-Month Mortality in Elderly Patients with Heart Failure
Suzuki, Sho; Motoki, Hirohiko; Kanzaki, Yusuke; Maruyama, Takuya; Hashizume, Naoto; Kozuka, Ayako; Yahikozawa, Kumiko; Kuwahara, Koichiro;
INTERNATIONAL HEART JOURNAL, 61(2), 325-331, Mar. 2020

Risk factors and clinical outcomes of functional decline during hospitalisation in very old patients with acute decompensated heart failure: an observational study
Yaku, Hidenori; Kato, Takao; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Kato, Masashi; Ikeda, Tomoyuki; Furukawa, Yutaka; Nakagawa, Yoshihisa; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;
BMJ Open, 10(2), Feb. 2020

A Statement on the Appropriate Administration of Tafamidis in Patients With Transthyretin Cardiac Amyloidosis
Endo, Jin; Sano, Motoaki; Izumiya, Yasuhiro; Tsujita, Kenichi; Nakamura, Kazufumi; Tahara, Nobuhiro; Kuwahara, Koichiro; Inomata, Takayuki; Ueda, Mitsuharu; Sekijima, Yoshiki; Ando, Yukio; Tsutsui, Hiroyuki; Isobe, Mitsuaki; Fukuda, Keiichi;
CIRCULATION JOURNAL, 84(1), 15-17, Jan. 2020

Association of an increase in serum albumin levels with positive 1-year outcomes in acute decompensated heart failure: A cohort study
Kato, Takao; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Kawato, Mitsunori; Seko, Yuta; Shiba, Masayuki; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;
PLOS ONE, 15(12), 2020

Cardio-renal and cardio-hepatic interactions predict cardiovascular events in elderly patients with heart failure
Okano, Takahiro; Motoki, Hirohiko; Minamisawa, Masatoshi; Kimura, Kazuhiro; Kanai, Masafumi; Yoshie, Koji; Higuchi, Satoko; Saigusa, Tatsuya; Ebisawa, Soichiro; Okada, Ayako; Shoda, Morio; Kuwahara, Koichiro;
PLOS ONE, 15(10), 2020

Association between body mass index and prognosis of patients hospitalized with heart failure
Seko, Yuta; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Shiba, Masayuki; Yamamoto, Erika; Yoshikawa, Yusuke; Yamashita, Yugo; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;
SCIENTIFIC REPORTS, 10(1), 2020

Impact of left ventricular ejection fraction on the effect of renin-angiotensin system blockers after an episode of acute heart failure: From the KCHF Registry
Yoshikawa, Yusuke; Tamaki, Yodo; Morimoto, Takeshi; Yaku, Hidenori; Yamamoto, Erika; Inuzuka, Yasutaka; Ozasa, Neiko; Kitai, Takeshi; Nagao, Kazuya; Sato, Yukihito; Kondo, Hirokazu; Tamura, Toshihiro; Nakagawa, Yoshihisa; Kuwahara, Koichiro; Kato, Takao; Kimura, Takeshi;
PLOS ONE, 15(9), 2020

Increased Ga(o)Expression Regulated by NRSF Plays a Key Role in the Development of Heart Failure Through the Impairment of Ca2+ Homeostasis
Inazumi, Hideaki; Nakagawa, Yasuaki; Moriuchi, Kenji; Kuwahara, Koichiro;
Circulation Research, 127, 2020

Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo
Ichimura, Hajime; Kadota, Shin; Kashihara, Toshihide; Yamada, Mitsuhiko; Ito, Kuniaki; Kobayashi, Hideki; Tanaka, Yuki; Shiba, Naoko; Chuma, Shinichiro; Tohyama, Shugo; Seto, Tatsuichiro; Okada, Kenji; Kuwahara, Koichiro; Shiba, Yuji;
SCIENTIFIC REPORTS, 10(1), 2020

MRTF-A promotes angiotensin II-induced inflammatory response and aortic dissection in mice
Ito, Sohei; Hashimoto, Yohei; Majima, Ryohei; Nakao, Eichi; Aoki, Hiroki; Nishihara, Michihide; Ohno-Urabe, Satoko; Furusho, Aya; Hirakata, Saki; Nishida, Norifumi; Hayashi, Makiko; Kuwahara, Koichiro; Fukumoto, Yoshihiro;
PLOS ONE, 15(3), 2020

Association with Controlling Nutritional Status (CONUT) Score and In-hospital Mortality and Infection in Acute Heart Failure
Kato, Takao; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Su, Kanae; Kawato, Mitsunori; Seko, Yuta; Inoko, Moriaki; Toyofuku, Mamoru; Furukawa, Yutaka; Nakagawa, Yoshihisa; Ando, Kenji; Kadota, Kazushige; Shizuta, Satoshi; Ono, Koh; Sato, Yukihito; Kuwahara, Koichiro; Ozasa, Neiko; Kimura, Takeshi;
SCIENTIFIC REPORTS, 10(1), 2020

C-reactive protein at discharge and 1-year mortality in hospitalised patients with acute decompensated heart failure: an observational study
Nishimoto, Yuji; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Su, Kanae; Kawato, Mitsunori; Seko, Yuta; Inoko, Moriaki; Toyofuku, Mamoru; Furukawa, Yutaka; Nakagawa, Yoshihisa; Ando, Kenji; Kadota, Kazushige; Shizuta, Satoshi; Ono, Koh; Kuwahara, Koichiro; Ozasa, Neiko; Sato, Yukihito; Kimura, Takeshi;
BMJ Open, 10(12), 2020

Prognostic significance of high-sensitivity cardiac troponin in patients with heart failure with preserved ejection fraction
Suzuki, Sho; Motoki, Hirohiko; Minamisawa, Masatoshi; Okuma, Yukari; Shoin, Wataru; Okano, Takahiro; Kimura, Kazuhiro; Ebisawa, Soichiro; Okada, Ayako; Kuwahara, Koichiro;
Heart and Vessels, 34(10), 1650-1656, Oct. 2019

Ankle-Brachial Index as a Prognostic Indicator in Patients with Atrial Fibrillation -A Subanalysis of the IMPACT-ABI Study
Oguchi Y, Saigusa T, Ebisawa S, Okada A, Motoki H, Kuwahara K
The Shinshu Medical Journal, 67(3), 197-204, 10 Jun. 2019

Establishment of a Healthcare System for Patients with Adult Congenital Heart Disease in Collaboration with Children’s Hospitals: The Nagano Model
Motoki H, Yasukochi S, Takigiku K, Takei K, Okamura T, Kimura K, Minamisawa M, Okada A, Saigusa T, Ebisawa S, Seto T, Shoda M, Okada K, Kuwahara K
Circ J, 83(2), 424-431, 2019

Epicardial Stone: Unfamiliar Calcified Mass at the Site of a Left Ventricular Old Myocardial Infarction
Tabata H, Motoki H, Sakai T, Okada A, Kuwahara K
Circ J, 83(9), 262, 2019

Atrial and brain natriuretic peptides: Hormones secreted from the heart
Nakagawa Y, Nishikimi T, Kuwahara K
PEPTIDES, 111, 18-25, 2019

A case of thrombolytic therapy with recombinant tissue plasminogen activator for mechanical valve thrombosis at 9 weeks of pregnancy in a Japanese woman
Komatsu T, Motoki H, Kimura K, Saigusa T, Ebisawa S, Yokokawa Y, Ando H, Ichino T, Kuwahara K.
J Cardiol Cases, 19(1), 15-18, 2019

Wire perforation causing cardiopulmonary arrest during radiofrequency hot balloon ablation for pulmonary vein isolation
Okano T, Okada A, Tabata H, Kobayashi H, Shoin W, Yoshie K, Oguchi Y, Shoda M, Kuwahara K
J Cardiol Cases, 19(5), 169-172, 2019

Association between reactive hyperemia peripheral arterial tonometry index and atrial fibrillation recurrence after catheter ablation
Kobayashi H, Okada A, Tabata H, Shoin W, Okano T, Yoshie K, Oguchi Y, Kato K, Shoda M, Kuwahara K
Int J Cardiol Heart Vasc, 24, 100385, 2019

Prognostic significance of high‑sensitivity cardiac troponin in patients with heart failure with preserved ejection fraction
Suzuki S, Motoki H, Minamisawa M, Okuma Y, Shoin W, Okano T, Kimura K, Ebisawa S, Okada A, Kuwahara K
Heart Vessels, 34(10), 1650-1656, 2019

Impact of inpatient cardiac rehabilitation on Barthel Index score and prognosis in patients with acute decompensated heart failure
Motoki H, Nishimura M, Kanai M, Kimura K, Minamisawa M, Yamamoto S, Saigusa T, Ebisawa S, Okada A, Kuwahara K
Int J Cardiol, 293, 125-130, 2019

MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages
An J, Naruse TK, Hinohara K, Soejima Y, Sawabe M, Nakagawa Y, Kuwahara K, Kimura A
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 133, 26-35, 2019

Comparison of leg loader and treadmill exercise for evaluating patients with peripheral artery disease
Ueki Y, Miura T, Mochidome T, Senda K, Ebisawa S, Saigusa T, Motoki H, Okada A, Koyama J, Kuwahara K
Heart Vessels, 34(4), 590-596, 2019

Role of echocardiography in assessing cardiac amyloidosis : a systematic review
Koyama J, Minamisawa M, Sekijima Y, Kuwahara K, Katsuyama T, Maruyama K
J Echocardiogr, 17(2), 64-75, 2019

Successful inferior vena cava filter removal using pacemaker lead extraction methods
Itagaki T, Okada A, Tabata H, Shoin W, Kobayashi H, Okano T, Oguchi Y, Mochidome T, Saigusa T, Ebisawa S, Motoki H, Shoda M, Kuwahara K
J Cardiol Cases, 19(4), 129-132, 2019

Biopsy detection and clinical management of acute lymphocytic myocarditis in pregnancy
Sunohara D, Motoki H, Saigusa T, Ebisawa S, Okada A, Ando H, Sato M, Kuwahara K
J Cardiol Cases, 20(5), 164-167, 2019

Comparison of Long-Acting and Short Acting Loop Diuretics in the Treatment of Heart Failure With Preserved Ejection Fraction
Suzuki S, Motoki H, Kanzaki Y, Maruyama T, Hashizume N, Kozuka A, Yahikozawa K, Kuwahara K
Circ Rep, 1, 137-141, 2019

Impact of Therapeutic Angiogenesis Using Autologous Bone Marrow-Derived Mononuclear Cells Implantation in Critical Limb Ischemia With Scleroderma - Subanalysis of the Long-Term Clinical Outcomes Survey
Shoji K, Yanishi K, Yoshimi R, Hamada N, Kondo K, Fujimoto K, Nakajima H, Kuwahara K, Higashi Y, Fukumoto Y, Murohara T, Matoba S; TACT Follow up Study Investigators
Circ J, 83(3), 662-671, 2019

Utility of copeptin for predicting long-term clinical outcomes inpatients with heart failure
Yoshikawa Y, Shiomi H, Kuwahara K, Sowa N, Yaku H, Yamashita Y, Tazaki J, Imai M, Kato T, Saito N, Shizuta S, Ono K, Kimura T
J Cardiol, 73(5), 379-385, 2019

Association of Mineralocorticoid Receptor Antagonist Use With All-Cause Mortality and Hospital Readmission in Older Adults With Acute Decompensated Heart Failure
Yaku H, Kato T, Morimoto T, Inuzuka Y, Tamaki Y, Ozasa N, Yamamoto E, Yoshikawa Y, Kitai T, Taniguchi R, Iguchi M, Kato M, Takahashi M, Jinnai T, Ikeda T, Nagao K, Kawai T, Komasa A, Nishikawa R, Kawase Y, Morinaga T, Toyofuku M, Seko Y, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Shizuta S, Ono K, Sato Y, Kuwahara K, Kimura T; KCHF Study Investigators
JAMA Netw Open, 2(6), e195892, 2019

Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia
Oshita K, Kozasa Y, Nakagawa Y, Kuwabara Y, Kuwahara K, Nakagawa T, Nakashima N, Hiraki T, Takano M
J Physiol Sci, 69(4), 653-660, 2019

Impact of inpatient cardiac rehabilitation on Barthel Index score and prognosis in patients with acute decompensated heart failure
Motoki, Hirohiko; Nishimura, Musashi; Kanai, Masafumi; Kimura, Kazuhiro; Minamisawa, Masatoshi; Yamamoto, Shuhei; Saigusa, Tatsuya; Ebisawa, Soichiro; Okada, Ayako; Kuwahara, Koichiro;
International Journal of Cardiology, 293, 125-130, 2019

Pathophysiological role of mitochondria-actin interactions in mouse hearts after myocardial infarction
Tanaka Tomohiro;Yasuda Satoshi;Sato Yoji;Kuwahara Koichiro;Kumagai Yoshito;Akaike Takaaki;Ide Tomomi;Ojida Akio;Mori Yasuo;Nishida Motohiro;Nishimura Akiyuki;Shimoda Kakeru;Shimauchi Tsukasa;Toyama Takashi;Kitajima Naoyuki;Ishikawa Tatsuya;Shindo Naoya;Numaga-Tomita Takuro
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92, 2-YIA-21, 2019

利尿薬の新しい展開
桑原 宏一郎
Shinzo, 51(4), 383-387, 2019

心房細動アブレーション：肺静脈隔離術 (Pulmonary vein isolation : PVI)
岡田 綾子;田畑 裕章;酒井 貴弘;三枝 達也;海老澤 聡一朗;元木 博彦;小山 潤;庄田 守男;桑原 宏一郎
The Shinshu Medical Journal, 67(4), 259-262, 2019

Predictive Value of Underweight Status for Patients with Peripheral Artery Disease with Claudication
Senda, Keisuke; Miura, Takashi; Minamisawa, Masatoshi; Ueki, Yasushi; Mochidome, Tomoaki; Nomi, Hidetomo; Shoin, Wataru; Higuchi, Satoko; Oguchi, Yasutaka; Nishimura, Hitoshi; Saigusa, Tatsuya; Ebisawa, Soichiro; Motoki, Hirohiko; Izawa, Atsushi; Koyama, Jun; Ikeda, Uichi; Kuwahara, Koichiro;
Angiology, 69(6), 513-522, Jul. 2018

Geriatric Nutritional Risk Index Predicts Cardiovascular Events in Patients at Risk for Heart Failure
Minamisawa, Masatoshi; Miura, Takashi; Motoki, Hirohiko; Ueki, Yasushi; Nishimura, Hitoshi; Shimizu, Kunihiko; Shoin, Wataru; Harada, Mikiko; Mochidome, Tomoaki; Senda, Keisuke; Yoshie, Koji; Oguchi, Yasutaka; Hashizume, Naoto; Abe, Naoyuki; Saigusa, Tatsuya; Ebisawa, Soichiro; Izawa, Atsushi; Koyama, Jun; Ikeda, Uichi; Kuwahara, Koichiro;
CIRCULATION JOURNAL, 82(6), 1614-+, Jun. 2018

Macro-pro-B-type natriuretic peptide (proBNP) and hidden macro-N-terminal proBNP: Case report
Nakagawa, Yasuaki; Nishikimi, Toshio; Sakai, Hiroshi; Ohno, Seiko; Kinoshita, Hideyuki; Inazumi, Hideaki; Moriuchi, Kenji; Kuwahara, Koichiro; Horie, Minoru; Kimura, Takeshi;
CLINICAL BIOCHEMISTRY, 52, 148-152, Feb. 2018

Drug-Eluting Versus Bare-Metal Stent Implantation with or without Cilostazol in the Treatment of the Superficial Femoral Artery
Miura T, Miyashita Y, Soga Y, Hozawa K, Doijiri T, Ikeda U, Kuwahara K on behalf of the DEBATE in SFA investigators
Circ Cardiovasc Interv, 11(8), e006564, 2018

Cutting Edge of Brain Natriuretic Peptide (BNP) Research - The Diversity of BNP Immunoreactivity and Its Clinical Relevance
Kuwahara K, Nakagawa Y, Nishikimi T
Circ J, 82(10), 2455-2461, 2018

T-wave alternans in a case with systemic lupus erythematosus-related myocarditis
Harada M, Motoki H, Kashima Y, Nakamura C, Hashizume N, Kishida D, Imamura H, Kuwahara K
J Cardiol Cases, 18(4), 119-122, 2018

Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
Minamisawa M, Koyama J, Kozuka A, Miura T, Saigusa T, Ebisawa S, Motoki H, Okada A, Ikeda U, Kuwahara K
Open Heart, 5, e000896, 2018

Demographics, Management, and In-Hospital Outcome of Hospitalized Acute Heart Failure Syndrome Patients in Contemporary Real Clinical Practice in Japan - Observations From the Prospective, Multicenter Kyoto Congestive Heart Failure (KCHF) Registry
Yaku H, Ozasa N, Morimoto T, Inuzuka Y, Tamaki Y, Yamamoto E, Yoshikawa Y, Kitai T, Taniguchi R, Iguchi M, Kato M, Takahashi M, Jinnai T, Ikeda T, Nagao K, Kawai T, Komasa A, Nishikawa R, Kawase Y, Morinaga T, Su K, Kawato M, Sasaki K, Toyofuku M, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Shizuta S, Ono K, Sato Y, Kuwahara K, Kato T, Kimura T, on behalf of the KCHF Study Investigators
Circ J, 82(11), 2811-2819, 2018

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence
Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M
Sci Signal, 11(556), eaat5185, 2018

Cross-sectional study of the association between day-to-day home blood pressure variability and visceral fat area measured using the dual impedance method
Kuwabara J, Kuwahara K, Kuwabara Y, Yasuno S, Nakagawa Y, Ueshima K, Kimura T
PLOS ONE, 13(11), e0206945, 2018

Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death
Fujii, Toshihito; Hirota, Keisho; Yasoda, Akihiro; Takizawa, Akiko; Morozumi, Naomi; Nakamura, Ryuichi; Yotsumoto, Takafumi; Kondo, Eri; Yamashita, Yui; Sakane, Yoriko; Kanai, Yugo; Ueda, Yohei; Yamauchi, Ichiro; Yamanaka, Shigeki; Nakao, Kazumasa; Kuwahara, Koichiro; Jindo, Toshimasa; Furuya, Mayumi; Mashimo, Tomoji; Inagaki, Nobuya; Serikawa, Tadao; Nakao, Kazuwa;
PLOS ONE, 13(3), 2018

CHARACTERISTIC AND CLINICAL OUTCOMES IN PATIENTS WITH LEFT VENTRICULAR NONCOMPACTION IN ADULTS: A NATIONWIDE SURVEY IN JAPAN
Minamisawa, Masatoshi; Koyama, Jun; Kuwahara, Koichiro; Ikeda, Uichi;
Journal of the American College of Cardiology, 71(11), 714-714, 2018

Single-center experience with percutaneous lead extraction of cardiac implantable electric devices
Okada, Ayako; Shoda, Morio; Tabata, Hiroaki; Shoin, Wataru; Kobayashi, Hideki; Okano, Takahiro; Yoshie, Koji; Oguchi, Yasutaka; Takeuchi, Takahiro; Kato, Ken; Kuwahara, Koichiro;
Journal of cardiology, 71(1-2), 192-196, 2018

内科学第五教室
KUWAHARA Koichiro
The Shinshu Medical Journal, 66(3), 226-226, 2018

Prevalence Rate of Ultrasonography for Detection of Deep Vein Thrombosis
Yamasaki Saeko;Motoki Hirohiko;Kuwahara Koichiro;Miura Takashi;Senda Keisuke;Sakai Takahiro;Oguchi Yasutaka;Kato Tamon;Saigusa Tatsuya;Ebisawa Soichiro;Okada Ayako
The Journal of Japanese College of Angiology, 58(9), 145-149, 2018

心不全バイオマーカーとしてのBNPの臨床的意義
桑原 宏一郎;
診断と治療 = Diagnosis and treatment, 105(12), 1603-1607, Dec. 2017

Prognostic Value of Ankle-Brachial Index in Patients Undergoing Percutaneous Coronary Intervention: In-Hospital and 1-Year Outcomes From the SHINANO Registry
Hashizume, Naoto; Miura, Takashi; Miyashita, Yusuke; Motoki, Hirohiko; Ebisawa, Soichiro; Izawa, Atsushi; Koyama, Jun; Ikeda, Uichi; Kuwahara, Koichiro; SHINANO Registry Investigators;
Angiology, 68(10), 884-892, Nov. 2017

Efficacy and Safety of an Orally Administered Selective Prostacyclin Receptor Agonist, Selexipag, in Japanese Patients With Pulmonary Arterial Hypertension
Tanabe, Nobuhiro; Ikeda, Satoshi; Tahara, Nobuhiro; Fukuda, Keiichi; Hatano, Masaru; Ito, Hiroshi; Nakayama, Tomotaka; Anzai, Toshihisa; Hashimoto, Akiyoshi; Inoue, Teruo; Kajinami, Kouji; Kihara, Yasuki; Kinoshita, Hideyuki; Kuwahara, Koichiro; Murohara, Toyoaki; Okazaki, Osamu; Sakai, Satoshi; Satoh, Toru; Takeda, Yutaka; Takeishi, Yasuchika; Taniguchi, Mitsugu; Watanabe, Hiroshi; Yamamoto, Takeshi; Yamauchi-Takihara, Keiko; Yoshioka, Koichiro; Sasayama, Shigetake;
CIRCULATION JOURNAL, 81(9), 1360-1367, Sep. 2017

Cardiac hyaluronan may be associated with the persistence of atrial fibrillation
Okada, Ayako; Kashima, Yuichiro; Tomita, Takeshi; Takeuchi, Takahiro; Oguchi, Yasutaka; Yoshie, Koji; Shoin, Wataru; Shoda, Morio; Nitta, Kenichi; Kuwahara, Koichiro; Imamura, Hiroshi;
Heart and Vessels, 32(9), 1144-1150, Sep. 2017

Omecamtiv mecarbil
木村 和広; 桑原 宏一郎;
循環器内科 = Cardioangiology, 82(2), 169-172, Aug. 2017

B-Type Natriuretic Peptide in Heart Failure With Preserved Ejection Fraction
Harada, Eisaku; Mizuno, Yuji; Kugimiya, Fumihito; Shono, Makoto; Maeda, Hiroyuki; Yano, Naotsugu; Kuwahara, Koichiro; Yasue, Hirofumi;
CIRCULATION JOURNAL, 81(7), 1006-+, Jul. 2017

Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model
Setozaki, Shuji; Minakata, Kenji; Masumoto, Hidetoshi; Hirao, Shingo; Yamazaki, Kazuhiro; Kuwahara, Koichiro; Ikeda, Tadashi; Sakata, Ryuzo;
JOURNAL OF VASCULAR SURGERY, 65(6), 1803-1812, Jun. 2017

Kyoto Congestive Heart Failure (KCHF) study: rationale and design
Yamamoto, Erika; Kato, Takao; Ozasa, Neiko; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Kitai, Takeshi; Morimoto, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Kato, Masashi; Takahashi, Mamoru; Jinnai, Toshikazu; Ikeda, Tomoyuki; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Nishikawa, Ryusuke; Kawase, Yuichi; Morinaga, Takashi; Kawashima, Tsuneaki; Motohashi, Yasuyo; Kawato, Mitsunori; Toyofuku, Mamoru; Sato, Yukihito; Kuwahara, Koichiro; Shioi, Tetsuo; Kimura, Takeshi
ESC HEART FAILURE, 4(3), 216-223, 17 Feb. 2017

MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts
Nakagawa, Yasuaki; Nishikimi, Toshio; Kuwahara, Koichiro; Fujishima, Aoi; Oka, Shogo; Tsutamoto, Takayoshi; Kinoshita, Hideyuki; Nakao, Kazuhiro; Cho, Kosai; Inazumi, Hideaki; Okamoto, Hiroyuki; Nishida, Motohiro; Kato, Takao; Fukushima, Hiroyuki; Yamashita, Jun K.; Wijnen, Wino J.; Creemers, Esther E.; Kangawa, Kenji; Minamino, Naoto; Nakao, Kazuwa; Kimura, Takeshi
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 6(2), 10 Feb. 2017

Endothelium-Derived C-Type Natriuretic Peptide Contributes to Blood Pressure Regulation by Maintaining Endothelial Integrity.
Nakao K, Kuwahara K, Nishikimi T, Nakagawa Y, Kinoshita H, Minami T, Kuwabara Y, Yamada C, Yamada Y, Tokudome T, Nagai-Okatani C, Minamino N, Nakao YM, Yasuno S, Ueshima K, Sone M, Kimura T, Kangawa K, Nakao K.
Hypertension, 69(2), 286-296, Feb. 2017

Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy.
Mori KP, Yokoi H, Kasahara M, Imamaki H, Ishii A, Kuwabara T, Koga K, Kato Y, Toda N, Ohno S, Kuwahara K, Endo T, Nakao K, Yanagita M, Mukoyama M, Mori K.
J Am Soc Nephrol, 28(1), 278-289, Jan. 2017

Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model
Ogasawara, Tatsuki; Okano, Satomi; Ichimura, Hajime; Kadota, Shin; Tanaka, Yuki; Minami, Itsunari; Uesugi, Motonari; Wada, Yuko; Saito, Naoto; Okada, Kenji; Kuwahara, Koichiro; Shiba, Yuji;
SCIENTIFIC REPORTS, 7, 2017

Diagnostic advantage of stress computed tomography myocardial perfusion over single-photon emission computed tomography for the assessment of myocardial ischemia
Ueki, Yasushi; Izawa, Atsushi; Kashiwagi, Daisuke; Nishiyama, Shigeki; Aso, Shinichi; Suzuki, Chihiro; Sakurai, Shumpei; Oguchi, Kazuhiro; Yazaki, Yoshikazu; Ikeda, Uichi; Kuwahara, Koichiro;
Journal of cardiology, 70(1-2), 147-154, 2017

Impressive predictive value of ankle-brachial index for very long-term outcomes in patients with cardiovascular disease: IMPACT-ABI study
Miura, Takashi; Minamisawa, Masatoshi; Ueki, Yasushi; Abe, Naoyuki; Nishimura, Hitoshi; Hashizume, Naoto; Mochidome, Tomoaki; Harada, Mikiko; Oguchi, Yasutaka; Yoshie, Koji; Shoin, Wataru; Saigusa, Tatsuya; Ebisawa, Soichiro; Motoki, Hirohiko; Koyama, Jun; Ikeda, Uichi; Kuwahara, Koichiro;
PLOS ONE, 12(6), 2017

Ankle-brachial index for the prognosis of cardiovascular disease in patients with mild renal insufficiency
Nishimura, Hitoshi; Miura, Takashi; Minamisawa, Masatoshi; Ueki, Yasushi; Abe, Naoyuki; Hashizume, Naoto; Mochidome, Tomoaki; Harada, Mikiko; Shimizu, Kunihiko; Shoin, Wataru; Yoshie, Koji; Oguchi, Yasutaka; Ebisawa, Soichiro; Motoki, Hirohiko; Izawa, Atsushi; Koyama, Jun; Ikeda, Uichi; Kuwahara, Koichiro;
INTERNAL MEDICINE, 56(16), 2103-2111, 2017

2-Year Natural History of Lower Limbs in Patients With End-stage Renal Disease on Hemodialysis Due to Diabetic Nephropathy; From PREDICT Study
Kato, Tamon; Miyashita, Yusuke; Miura, Takashi; Ebisawa, Souitirou; Saigusa, Tatsuya; Kuwahara, Koichiro;
Journal of the American College of Cardiology, 70(18), B71-B71, 2017

心不全診療におけるナトリウム利尿ペプチドの臨床応用のインパクト
桑原 宏一郎
Shinzo, 49(8), 795-795, 2017

Impact of Natriuretic Peptides on Clinical Practice of Cardiovascular Medicine
KUWAHARA Koichiro
The Shinshu Medical Journal, 65(5), 247-248, 2017

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.
Numaga-Tomita T, Kitajima N, Kuroda T, Nishimura A, Miyano K, Yasuda S, Kuwahara K, Sato Y, Ide T, Birnbaumer L, Sumimoto H, Mori Y, Nishida M.
Sci Rep, 6, 39383, Dec. 2016

Brain Natriuretic Peptide Counteracting the Renin-angiotensin-aldosterone System in Accelerated Malignant Hypertension.
Nakagawa H, Mizuno Y, Harada E, Morikawa Y, Kuwahara K, Saito Y, Yasue H.
Am J Med Sci, 352(5), 534-539, Nov. 2016

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.
Kitajima N, Numaga-Tomita T, Watanabe M, Kuroda T, Nishimura A, Miyano K, Yasuda S, Kuwahara K, Sato Y, Ide T, Birnbaumer L, Sumimoto H, Mori Y, Nishida M.
Sci Rep, 6, 37001, Nov. 2016

Brain-specific natriuretic peptide receptor-B deletion attenuates high-fat diet-induced visceral and hepatic lipid deposition in mice.
Yamashita Y, Yamada-Goto N, Katsuura G, Ochi Y, Kanai Y, Miyazaki Y, Kuwahara K, Kanamoto N, Miura M, Yasoda A, Ohinata K, Inagaki N, Nakao K.
PEPTIDES, 81, 38-50, Jul. 2016

Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure.
Ohno S, Yokoi H, Mori K, Kasahara M, Kuwahara K, Fujikura J, Naito M, Kuwabara T, Imamaki H, Ishii A, Saleem MA, Numata T, Mori Y, Nakao K, Yanagita M, Mukoyama M.
Sci Rep, 6, 27192, Jun. 2016

Secretion of ProBNP is Regulated by Mir30-GALNTs Axis Dependent O-linked Glycosylation in the Pathological Myocardium
Nakagawa, Yasuaki; Kuwahara, Koichiro; Nishikimi, Toshio; Kinoshita, Hideyuki; Inazumi, Hideki; Moriuchi, Kenji; Kato, Takao; Minamino, Naoto; Nacho, Kazuwa; Kimura, Takeshi;
Circulation, 134, 2016

The renin-angiotensin system promotes arrhythmogenic substrates and lethal arrhythmias in mice with non-ischaemic cardiomyopathy
Yamada, Chinatsu; Kuwahara, Koichiro; Yamazaki, Masatoshi; Nakagawa, Yasuaki; Nishikimi, Toshio; Kinoshita, Hideyuki; Kuwabara, Yoshihiro; Minami, Takeya; Yamada, Yuko; Shibata, Junko; Nakao, Kazuhiro; Cho, Kosai; Arai, Yuji; Honjo, Haruo; Kamiya, Kaichiro; Nakao, Kazuwa; Kimura, Takeshi;
Cardiovascular Research, 109(1), 162-173, 2016

Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites.
Nishikimi T, Nakagawa Y, Minamino N, Ikeda M, Tabei K, Fujishima A, Takayama K, Akimoto K, Yamada C, Nakao K, Minami T, Kuwabara Y, Kinoshita H, Tsutamoto T, Ishimitsu T, Kangawa K, Kuwahara K, Nakao K.
Am J Physiol Regul Integr Comp Physiol, 309(6), R639-49, Sep. 2015

The organ-protective effect of N-type Ca(2+) channel blockade.
Kuwahara K, Kimura T.
Pharmacol Ther, 151, 1-7, Jul. 2015

The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth.
Nakao K, Osawa K, Yasoda A, Yamanaka S, Fujii T, Kondo E, Koyama N, Kanamoto N, Miura M, Kuwahara K, Akiyama H, Bessho K, Nakao K.
Sci Rep, 5, 10554, May 2015

Ectopic automaticity induced in ventricular myocytes by transgenic overexpression of HCN2.
Oshita K, Itoh M, Hirashima S, Kuwabara Y, Ishihara K, Kuwahara K, Nakao K, Kimura T, Nakamura K, Ushijima K, Takano M.
J Mol Cell Cardiol, 80, 81-9, Mar. 2015

Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model.
Tanaka M, Yamaguchi S, Yamazaki Y, Kinoshita H, Kuwahara K, Nakao K, Jay PY, Noda T, Nakamura T.
Sci Rep, 5, 7826, Jan. 2015

Differential Relationships Between Anemia and Outcome in Subgroups of Patients With Chronic Heart Failure.
Nakagawa Y, Yasuno S, Kuwahara K.
Circ J, 79(9), 1893-4, 2015

The Effects of Super-Flux (High Performance) Dialyzer on Plasma Glycosylated Pro-B-Type Natriuretic Peptide (proBNP) and Glycosylated N-Terminal proBNP in End-Stage Renal Disease Patients on Dialysis
Nakagawa, Yasuaki; Nishikimi, Toshio; Kuwahara, Koichiro; Yasuno, Shinji; Kinoshita, Hideyuki; Kuwabara, Yoshihiro; Nakao, Kazuhiro; Minami, Takeya; Yamada, Chinatsu; Ueshima, Kenji; Ikeda, Yoshihiro; Okamoto, Hiroyuki; Horii, Kazukiyo; Nagata, Kiyoshi; Kangawa, Kenji; Minamino, Naoto; Nakao, Kazuwa
PLOS ONE, 9(3), 25 Mar. 2014

Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure
Yamada, Yuko; Kinoshita, Hideyuki; Kuwahara, Koichiro; Nakagawa, Yasuaki; Kuwabara, Yoshihiro; Minami, Takeya; Yamada, Chinatsu; Shibata, Junko; Nakao, Kazuhiro; Cho, Kosai; Arai, Yuji; Yasuno, Shinji; Nishikimi, Toshio; Ueshima, Kenji; Kamakura, Shiro; Nishida, Motohiro; Kiyonaka, Shigeki; Mori, Yasuo; Kimura, Takeshi; Kangawa, Kenji; Nakao, Kazuwa;
Cardiovascular Research, 104(1), 183-193, 2014

Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy
Yasuno, Shinji; Kuwahara, Koichiro; Kinoshita, Hideyuki; Yamada, Chinatsu; Nakagawa, Yasuaki; Usami, Satoru; Kuwabara, Yoshihiro; Ueshima, Kenji; Harada, Masaki; Nishikimi, Toshio; Nakao, Kazuwa;
British Journal of Pharmacology, 170(7), 1384-1395, Dec. 2013

Increased Expression of HCN Channels in the Ventricular Myocardium Contributes to Enhanced Arrhythmicity in Mouse Failing Hearts
Kuwabara, Yoshihiro; Kuwahara, Koichiro; Takano, Makoto; Kinoshita, Hideyuki; Arai, Yuji; Yasuno, Shinji; Nakagawa, Yasuaki; Igata, Sachiyo; Usami, Satoru; Minami, Takeya; Yamada, Yuko; Nakao, Kazuhiro; Yamada, Chinatsu; Shibata, Junko; Nishikimi, Toshio; Ueshima, Kenji; Nakao, Kazuwa;
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2(3), Jun. 2013

Adrenomedullin in Cardiovascular Disease: A Useful Biomarker, its Pathological Roles and Therapeutic Application
Nishikimi, Toshio; Kuwahara, Koichiro; Nakagawa, Yasuaki; Kangawa, Kenji; Nakao, Kazuwa;
CURRENT PROTEIN & PEPTIDE SCIENCE, 14(4), 256-267, Jun. 2013

Complexity of molecular forms of B-type natriuretic peptide in heart failure
Nishikimi, Toshio; Kuwahara, Koichiro; Nakagawa, Yasuaki; Kangawa, Kenji; Minamino, Naoto; Nakao, Kazuwa;
HEART, 99(10), 677-679, May 2013

Direct Immunochemiluminescent Assay for proBNP and Total BNP in Human Plasma proBNP and Total BNP Levels in Normal and Heart Failure
Nishikimi, Toshio; Okamoto, Hiroyuki; Nakamura, Masahiro; Ogawa, Naoko; Horii, Kazukiyo; Nagata, Kiyoshi; Nakagawa, Yasuaki; Kinoshita, Hideyuki; Yamada, Chinatsu; Nakao, Kazuhiro; Minami, Takeya; Kuwabara, Yoshihiro; Kuwahara, Koichiro; Masuda, Izuru; Kangawa, Kenji; Minamino, Naoto; Nakao, Kazuwa;
PLOS ONE, 8(1), 2013

Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice
Nishida, Motohiro; Ishikawa, Tatsuya; Saiki, Shota; Sunggip, Caroline; Aritomi, Shizuka; Harada, Eri; Kuwahara, Koichiro; Hirano, Katsuya; Mori, Yasuo; Kim-Mitsuyama, Shokei;
Biochemical and biophysical research communications, 434(2), 210-216, 2013

Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice
Minami, Takeya; Kuwahara, Koichiro; Nakagawa, Yasuaki; Takaoka, Minoru; Kinoshita, Hideyuki; Nakao, Kazuhiro; Kuwabara, Yoshihiro; Yamada, Yuko; Yamada, Chinatsu; Shibata, Junko; Usami, Satoru; Yasuno, Shinji; Nishikimi, Toshio; Ueshima, Kenji; Sata, Masataka; Nakano, Hiroyasu; Seno, Takahiro; Kawahito, Yutaka; Sobue, Kenji; Kimura, Akinori; Nagai, Ryozo; Nakao, Kazuwa;
EMBO JOURNAL, 31(23), 4428-4440, 2012

Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes
Hata, Leo; Murakami, Masao; Kuwahara, Koichiro; Nakagawa, Yasuaki; Kinoshita, Hideyuki; Usami, Satoru; Yasuno, Shinji; Fujiwara, Masataka; Kuwabara, Yoshihiro; Minami, Takeya; Yamada, Yuko; Yamada, Chinatsu; Nakao, Kazuhiro; Ueshima, Kenji; Nishikimi, Toshio; Nakao, Kazuwa;
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 50(6), 972-981, Jun. 2011

Induction and Enhancement of Cardiac Cell Differentiation from Mouse and Human Induced Pluripotent Stem Cells with Cyclosporin-A
Fujiwara, Masataka; Yan, Peishi; Otsuji, Tomomi G.; Narazaki, Genta; Uosaki, Hideki; Fukushima, Hiroyuki; Kuwahara, Koichiro; Harada, Masaki; Matsuda, Hiroyuki; Matsuoka, Satoshi; Okita, Keisuke; Takahashi, Kazutoshi; Nakagawa, Masato; Ikeda, Tadashi; Sakata, Ryuzo; Mummery, Christine L.; Nakatsuji, Norio; Yamanaka, Shinya; Nakao, Kazuwa; Yamashita, Jun K.;
PLOS ONE, 6(2), 2011

Pathophysiological Remodeling of Mouse Cardiac Myocytes Expressing Dominant Negative Mutant of Neuron Restrictive Silencing Factor
Takano, Makoto; Kinoshita, Hideyuki; Shioya, Takao; Itoh, Masayuki; Nakao, Kazuwa; Kuwahara, Koichiro;
CIRCULATION JOURNAL, 74(12), 2712-2719, Dec. 2010

Myocardin-Related Transcription Factor A Is a Common Mediator of Mechanical Stress- and Neurohumoral Stimulation-Induced Cardiac Hypertrophic Signaling Leading to Activation of Brain Natriuretic Peptide Gene Expression
Kuwahara, Koichiro; Kinoshita, Hideyuki; Kuwabara, Yoshihiro; Nakagawa, Yasuaki; Usami, Satoru; Minami, Takeya; Yamada, Yuko; Fujiwara, Masataka; Nakao, Kazuwa;
MOLECULAR AND CELLULAR BIOLOGY, 30(17), 4134-4148, Sep. 2010

Regulation and significance of atrial and brain natriuretic peptides as cardiac hormones
Kuwahara, Koichiro; Nakao, Kazuwa;
Endocrine journal, 57(7), 555-565, Jul. 2010

Podocyte-specific expression of tamoxifen-inducible Cre recombinase in mice
Yokoi, Hideki; Kasahara, Masato; Mukoyama, Masashi; Mori, Kiyoshi; Kuwahara, Koichiro; Fujikura, Junji; Arai, Yuji; Saito, Yoko; Ogawa, Yoshihisa; Kuwabara, Takashige; Sugawara, Akira; Nakao, Kazuwa;
NEPHROLOGY DIALYSIS TRANSPLANTATION, 25(7), 2120-2124, Jul. 2010

Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction
Small, Eric M.; Thatcher, Jeffrey E.; Sutherland, Lillian B.; Kinoshita, Hideyuki; Gerard, Robert D.; Richardson, James A.; DiMaio, J. Michael; Sadek, Hesham; Kuwahara, Koichiro; Olson, Eric N.;
Circulation Research, 107(2), 294-U263, 2010

Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart
Kinoshita, Hideyuki; Kuwahara, Koichiro; Nishida, Motohiro; Jian, Zhong; Rong, Xianglu; Kiyonaka, Shigeki; Kuwabara, Yoshihiro; Kurose, Hitoshi; Inoue, Ryuji; Mori, Yasuo; Li, Yuhao; Nakagawa, Yasuaki; Usami, Satoru; Fujiwara, Masataka; Yamada, Yuko; Minami, Takeya; Ueshima, Kenji; Nakao, Kazuwa;
Circulation Research, 106(12), 1849-U153, 2010

Guanylyl Cyclase-A Inhibits Angiotensin II Type 2 Receptor-Mediated Pro-Hypertrophic Signaling in the Heart
Li, Yuhao; Saito, Yoshihiko; Kuwahara, Koichiro; Rong, Xianglu; Kishimoto, Ichiro; Harada, Masaki; Adachi, Yuichiro; Nakanishi, Michio; Kinoshita, Hideyuki; Horiuchi, Masatsugu; Murray, Michael; Nakao, Kazuwa;
Endocrinology, 150(8), 3759-3765, Aug. 2009

p300 Plays a Critical Role in Maintaining Cardiac Mitochondrial Function and Cell Survival in Postnatal Hearts
Nakagawa, Yasuaki; Kuwahara, Koichiro; Takemura, Genzo; Akao, Masaharu; Kato, Masashi; Arai, Yuji; Takano, Makoto; Harada, Masaki; Murakami, Masao; Nakanishi, Michio; Usami, Satoru; Yasuno, Shinji; Kinoshita, Hideyuki; Fujiwara, Masataka; Ueshima, Kenji; Nakao, Kazuwa;
Circulation Research, 105(8), 746-U57, 2009

T-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice With Heart Failure
Kinoshita, Hideyuki; Kuwahara, Koichiro; Takano, Makoto; Arai, Yuji; Kuwabara, Yoshihiro; Yasuno, Shinji; Nakagawa, Yasuaki; Nakanishi, Michio; Harada, Masaki; Fujiwara, Masataka; Murakami, Masao; Ueshima, Kenji; Nakao, Kazuwa;
Circulation, 120(9), 743-U66, 2009

The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2
Kuratomi, Shinobu; Ohmori, Yoko; Ito, Masayuki; Shimazaki, Kuniko; Muramatsu, Shin-ichi; Mizukami, Hiroaki; Uosaki, Hideki; Yamashita, Jun K.; Arai, Yuji; Kuwahara, Koichiro; Takano, Makoto;
Cardiovascular Research, 83(4), 682-687, 2009

Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation
Nakanishi, Michio; Harada, Masaki; Kishimoto, Ichiro; Kuwahara, Koichiro; Kawakami, Rika; Nakagawa, Yasuaki; Yasuno, Shinji; Usami, Satoru; Kinoshita, Hideyuki; Adachi, Yuichiro; Fukamizu, Akiyoshi; Saito, Yoshihiko; Nakao, Kazuwa;
CIRCULATION JOURNAL, 71(8), 1310-1316, Aug. 2007

Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity
Kuwahara, Koichiro; Pipes, Gordon C. Teg; McAnally, John; Richardson, James A.; Hill, Joseph A.; Bassel-Duby, Rhonda; Olson, Eric N.;
JOURNAL OF CLINICAL INVESTIGATION, 117(5), 1324-1334, May 2007

Mitochondrial cardiomyopathy evaluated with cardiac magnetic resonance
Nakanishi, Michio; Harada, Masaki; Tadamura, Eiji; Kotani, Hirokazu; Kawakami, Rika; Kuwahara, Koichiro; Nakagawa, Yasuaki; Usami, Satoru; Kinoshita, Hideyuki; Fujiwara, Masataka; Hosoda, Kiminori; Ueshima, Kenji; Nakao, Kazuwa;
Circulation, 116(2), E25-E26, 2007

Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin
Barrientos, Tomasa; Frank, Derk; Kuwahara, Koichiro; Bezprozvannaya, Svetlana; Pipes, G. C. Teg; Bassel-Duby, Rhonda; Richardson, James A.; Katus, Hugo A.; Olson, Eric N.; Frey, Norbert;
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Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes
Nakagawa, Yasuaki; Kuwahara, Koichiro; Harada, Masaki; Takahashi, Nobuki; Yasuno, Shinji; Adachi, Yuichiro; Kawakami, Rika; Nakanishi, Michio; Tanimoto, Keiji; Usami, Satoru; Kinoshita, Hideyuki; Saito, Yoshihiko; Nakao, Kazuwa;
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 41(6), 1010-1022, Dec. 2006

TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
Kuwahara, Koichiro; Wang, Yanggan; McAnally, John; Richardson, James A.; Bassel-Duby, Rhonda; Hill, Joseph A.; Olson, Eric N.;
JOURNAL OF CLINICAL INVESTIGATION, 116(12), 3114-3126, Dec. 2006