KOMATSU, MITSUHISA | Shinshu University Researcher Directory

Academic Organization	Academic Assembly　School of Medicine and Health Sciences　Institute of Medicine	TEL
Education and Research Organization	School of Medicine　Department of Medicine (Diabetes, Endocrinology and Metabolism)	FAX
Position	Professor	Mail Address
Address		Web site

Profile

Research Field: 糖尿病学

Current Subject: 糖尿病の発症機構

Academic Background: Graduate School
Shinshu University , (Graduate School, Division of Medicine) , 1990

College
Shinshu University , (Faculty of Medicine) , 1986

Degree
Doctor of Medicine

Research Career: Research Career
2012- , 信州大学医学部内科学講座　糖尿病・内分泌代謝内科　教授
2010- , 信州大学大学院加齢病態制御学　教授
1992-1996 , Cornell University

Research

Books, Articles, etc.: Books
内分泌疾患（先端巨大症、クッシング症候群、原発性アルドステロン症）　, 別冊プラクティス , 85-92
2014
Author:竹重恵子、関戸貴志、駒津光久

ブドウ糖によるインシュリン分泌とインクレチンー生理的意義の理解に向けてー　特報　第５０回2013年度ベルツ賞受賞論文, 最新医学 69 , 128-151
2014
Author:駒津光久、佐藤吉彦、相澤徹

SU薬のポジショニング　SU薬はもういらないのか　, 糖尿病診療マスター 12 , 156-161
2014
Author:駒津光久

独居高齢者の症例報告, DIABETES UPDATE 3 , 28-32
2014
Author:樋渡大、駒津光久

SGLUT2阻害薬の基礎データをみる　編集加来浩平　２型糖尿病治療の新展開〜SGLUT2阻害薬登場による新たな可能性〜, 先端医学社 , 30-43
2014
Author:駒津光久

KATP非依存性ブドウ糖応答性シグナルは生理的に重要か？, 内分泌・糖尿病・代謝内科 39 2, 122-127
2014
Author:駒津光久

GPR40作動薬　糖尿病治療薬はどこまできたかー新規治療薬開発の現状—, 月刊糖尿病 6 9, 49-55
2014
Author:柴田有亮、河合裕子、駒津光久

薬剤による食後高血糖治療：グリニド薬　月刊糖尿病　食後高血糖改善薬による糖尿病治療, 医学出版 5 , 60-65
2013
Author:北原順一郎、河合裕子、駒津光久

糖尿病における急性期管理—糖尿病患者の急性合併症への正しい対応—, プラクティス 30 , 289
2013
Author:駒津光久

医師・医療スタッフをつなぐ　スキルと知識の維持と向上を目指して, プラクティス 30 , 530
2013
Author:駒津光久

加齢に伴う耐糖能低下の機序．, 内分泌・糖尿病・代謝内科　 35 , 9-12
2012
Author:大久保洋輔、竹重恵子、駒津光久

全身疾患と耳鼻咽喉科　内分泌—内分泌疾患から生じた耳鼻咽喉科疾患—, JOHNS 28 , 1403-1406
2012
Author:鈴木悟、駒津光久

膵臓における高血糖の急性毒性, 救急・集中治療 24 , 534-538
2012
Author:樋渡大、関戸貴志、駒津光久

地域医療の現場で考える糖尿病診療の均てん化, PRACTICE 29 , 105-108
2012
Author:相澤徹、大西雄太郎、駒津光久、野田光彦

Pituitary resistance to thyroid hormones: pathophysiology and therapeutic options, Endocrine 40 3, 366-371
2011(Sep. 29)
Author:Suzuki S, Shigematsu S, Inaba H, Takei M, Takeda T, Komatsu M

高齢者におけるGLP-1受容体作動薬の使い方, Geriatric Medicine 49 , 879-882
2011
Author:山崎雅則、駒津光久

グリニドとSU薬, 佐田政隆、下村伊一郎、野出孝一、綿田裕孝編　血管糖尿病2011 , 214-218
フジメディカル出版 2011
Author:駒津光久

２型糖尿病のインスリン治療　インスリン治療がしばしば難渋するケース　高齢者や認知症患者, 荒木栄一、綿田裕孝編　最新インスリン療法 , 180-184
中山書店 2011
Author:駒津光久

高齢者の血糖コントロール, PRACTICE 28 , 184-185
2011
Author:駒津光久

機能的膵β細胞量を標的としたあらたな糖尿病治療—GLP-１治療の展望—, International Review of Diabetes 2 , 24-25
2010
Author:駒津光久

２型糖尿病における膵β細胞量とインクレチンの役割, International Review of Diabetes 2 , 9-23
2010
Author:石原寿光、Meier JJ、駒津光久、税所芳史

Closed-loopとopen-loopによる血糖制御, 内分泌・糖尿病・代謝内科 30 , 591-595
化学評論社 2010
Author:駒津光久

高齢者糖尿病の最新薬物療法　高齢者；グリニド（速効型インスリン分泌促進薬）, Geriatric Medicine 47 , 821-825
2009
Author:駒津光久、相澤徹

糖尿病療養指導　生活指導と自己管理　「糖尿病　最新の治療　2010-2012」, 南江堂 , 267-269
2009
Author:駒津光久

β細胞の評価〜in vitro膵灌流実験〜, Islet Equality 2 , 3-6
2009
Author:駒津光久

次世代型人工膵臓研究会作業部会：ベッドサイド型人工膵臓を用いたグルコースクランプ法の標準化, PRACTICE 26 , 557-562
2009
Author:駒津光久、絵本正憲、田村好史、西田健朗、小川裕、田尻祐司、松葉育郎、渥美義仁、野田光彦

高齢者糖尿病の最新薬物療法　高齢者；グリニド（速効型インスリン分泌促進薬）, Geriatric Medicine 47 , 821-825
2009
Author:駒津光久、相澤徹

インスリン分泌促進薬、αGI, 臨床と研究 86 , 31-35
2009
Author:駒津光久、相澤徹

糖尿病を３段階で治療する, 糖尿病のすべてがわかる本　改訂新版 , 144-167
2008
Author:相澤徹、山内恵史、駒津光久

病態におけるインスリン分泌　２型糖尿病, 新時代の糖尿病学（１） 66 , 200-204
日本臨床 2008
Author:駒津光久、相澤徹

ブドウ糖によるKATPチャンネル非依存性のインスリン分泌機構, 新時代の糖尿病学（１） 66 , 182-186
日本臨床 2008
Author:駒津光久

＜＜糖尿病マネージメントup-to-date＞＞経口糖尿病薬, 内科 101 1, 18-24
2008
Author:駒津光久、山内恵史、相澤徹

ブドウ糖刺激によるインスリン開口放出の生理学, 内分泌・糖尿病科 25 , 206-212
2007
Author:駒津光久

アナログインスリンを使いこなす, 日本医事新報 4340 , C1-C6
2007
Author:駒津光久、門伝剛、近藤照貴、勝盛弘三、鈴木克典

糖尿病〜血糖降下のための薬物療法、その選択〜, MEDICAMENT NEWS 1904 , 10-12
2007
Author:駒津光久、相澤徹

＜治療の最前線＞インスリンアナログの新たな時代, 信州医誌 55 , 23-24
2007
Author:駒津光久

グリニド薬ってどんな薬ですか？, 糖尿病療養指導Q&A , 158-160
中外医学社 2007
Author:駒津光久、相澤徹

アミノ酸, 脂肪酸とインスリン分泌, 糖尿病学　基礎と臨床 , 101-104
2007
Author:駒津光久

インスリン分泌におけるKATPチャネル非依存性経路の役割, 糖尿病学　基礎と臨床 , 78-82
2007
Author:相澤徹、駒津光久、佐藤吉彦

高齢糖尿病患者における注意点　野田光彦編, 糖尿病臨床スキルアップ　外来・病棟診療ノート , 280-287
南光堂 2007
Author:駒津光久

加齢とインスリン, 内分泌・糖尿病科 23 , 334-339
2006
Author:駒津光久

高齢患者さんにおける低血糖の予防と対応, 糖尿病ケア 3 , 58-63
2006
Author:駒津光久、相澤徹

高齢者糖尿病患者における注意点．糖尿病の臨床—基礎知識を実践にいかす, medicina 43 , 82-84
2006
Author:駒津光久

経口血糖降下薬療法における留意点．特集：高齢者糖尿病, 日本臨床 64 , 93-98
2005
Author:駒津光久、橋爪潔志

糖尿病の病態と分子メカニズム(i)膵島, 膵島，春日雅人編：生活習慣病がわかる．わかる実験医学シリーズ , 34-44
羊土社，東京 2005
Author:相澤　徹，駒津光久

Pancreatic ss-cell, a unique fuel senser. Dakshinamurti K, Zempleni J eda: Nutients and Cell Signaling, 533-564
Dekker/CRC Press, New York, 2005

KATPチャネル非依存性経路とその意義, 編：糖尿病カレントライブラリー2 インスリン分泌 , 19-22
文光堂，東京 2004
Author:佐藤吉彦，駒津光久，矢島博樹，相澤　徹

糖尿病を３段階で治療する, 140-163
糖尿病のすべてがわかる本．矢沢サイエンスオフィス編　学研 2003
Author:相澤徹、山内恵史、駒津光久

糖尿病, 601-606
臨床薬物治療学　アークメデｲア 2000
Author:相澤徹、駒津光久、山内恵史

耐糖能異常, 62-67
Mebio別冊 Multiple risk factor syndrome 2. インスリン抵抗性の位置づけ 1998
Author:相澤徹、駒津光久、山内恵史、橋爪潔志

インスリンの生合成・分泌のメカニズム：ATP依存性K+ チャネル以外を介するインスリン分泌制御．河盛隆造、春日雅人編, 専門医のための糖尿病学レビュー'97 , 22-29
総合医学社、東京 1997
Author:駒津光久、相澤徹、橋爪潔志

糖尿病の成因の究明「インスリン分泌機序と糖尿病」, Progress in Medicine 17 , 1267-1272
1997
Author:相澤徹、駒津光久、山内恵史、橋爪潔志

HIT細胞におけるブドウ糖によるCa2+非依存性のインスリン分泌増強作用, Peptide Hormones in Pancreas 17 , 32-36
1997
Author:駒津光久、相澤徹、G.W.G.Sharp、橋爪潔志

Glucose ToxicityとLipotoxicity., 内分泌・糖尿科 5 , 44-52
1997
Author:相澤徹、駒津光久、山内恵史、橋爪潔志

インスリン分泌「非KATP経路」, 糖尿病 40 , 655-658
1997
Author:駒津光久、橋爪潔志

インスリン分泌の分子機構, Diabetes Journal 24 , 133-140
1996
Author:相澤徹、駒津光久、橋爪潔志

膵β細胞における「K+ATPチャネル/カルシウムドグマ」の崩壊, Mebio 13 10, 118-124
1996
Author:相澤徹、麻沼奈穂子、佐藤吉彦、駒津光久、橋爪潔志

膵β細胞におけるブドウ糖によるインスリン分泌刺激作用の多様性, Peptide Hormones in Pancreas 16 , 13-16
1996
Author:麻沼奈穂子、駒津光久、G.W.G.Sharp、相澤徹、佐藤吉彦、石原藤樹、橋爪潔志

ブドウ糖による膵Ｂ細胞刺激, 信州医学雑誌 42 , 281-288
1994
Author:相澤徹、佐藤吉彦、田口奈穂子、石原藤樹、駒津光久、橋爪潔志

ATP-sensitive K+ channel-independent, glucose-induced signalling in the pancreatic B-cell. In Insulin secretion and pancreatic B-cell research, 167-172
Flatt PR, Lenzen S, Eds. London, Portland Press Ltd. 1994
Author:T Aizawa, Y Sato, M Komatsu, F Ishihara, N Taguchi, K Hashizume

ATP感受性K+チャネル非依存性のブドウ糖によるインスリン分泌刺激．−ブドウ糖代謝との乖離−, Peptide Hormones in Pancreas 13 , 204-207
1993
Author:石原藤樹、相澤徹、佐藤吉彦、田口奈穂子、駒津光久、橋爪潔志

マストパランによるインスリン放出刺激機構の解明, Peptide Hormones in Pancreas 12 , 17-22
1992
Author:駒津光久、相澤徹、佐藤吉彦、岡田尚美、西井中子、高須信行、山田隆司

ＡＴＰ感受性Ｋチャンネル非依存性のブドウ糖によるインスリン分泌刺激のメカニズム, Peptide Hormones in Pancreas 12 , 23-27
1992
Author:佐藤吉彦、駒津光久、相澤徹、岡田尚美、山田隆司

ATP-sensitive K+ channel非依存性のグルコ-スによるシグナリング．七里元亮編、第３５回日本糖尿病学会年次学術集会記録, 糖尿病記録号1992 , 93-98
医学図書出版 1992
Author:相澤徹、駒津光久、佐藤吉彦

糖代謝の測定法：-ｸﾞﾙｺ-ｽｸﾗﾝﾌﾟ法-, Diabetes Frontier 3 , 373-380
1992
Author:相澤徹、駒津光久、浅輪孝幸、長澤慶尚、山田隆司

Prediction of development of diabetes among overweight adults with normal or impaired glucose tolerance: a ten-year follow-up study, 213-216
In Prevention and Treatment of NIDDM Goto Y, Lee TH, Kanako T, Shigeta Y, Eds. London, Smith-Gordon 1992
Author:Y Nagasawa, T Yamada, M Ishihara, M Komatsu, I Komiya, T Shinoda, T Aizawa

Existance of ATP-sensitive K+ channel-independent pathways in glucose-induced insulin release by the pancreatic B-cell., 55-59
In Prevention and Treatment of NIDDM Goto Y, Lee TH, Kaneko T, Shigeta Y, Eds. London, Smith-Gordon 1992
Author:Y Sato, M Komatsu, N Okada, T Aizawa, T Yamada

膵ラ氏島H2O2産性とDNA損傷−Ca2+とPKCの相乗効果−糖尿病発症初期シグナル, 日本臨床代謝学会記録 26 , 72-73
1989
Author:高須信行、小宮一郎、浅輪孝幸、長沢慶尚、駒津光久、相澤徹

糖尿病患者の手術時における人工膵を用いた血糖管理について, 内科 62 , 337-344
1988
Author:石原雅樹、横川中子、駒津光久、山田隆司

床下部-下垂体視ホルモン系, 現代医療 20 , 1653-1658
1988
Author:山田隆司、山内恵史、石原雅樹、駒津光久

インスリン分泌の分子機構．G蛋白シグナルとインスリン分泌機構　ATP感受性K+ チャネルを介さないブドウ糖によるインスリン分泌刺激, ４-10
分子糖尿病学の進歩１９９８金原出版 1988
Author:駒津光久、相澤徹、橋爪潔志

Articles
A Case of a Cystic Parathyroid Adenoma with Marked Hyperparathyroidism but Difficult Preoperative Diagnostic Imaging
The Shinshu Medical Journal,70(3):189-194 2022(Jun.)
Author:KUBOTA Satoshi, SHIMADA Yasuho, TAKAYAMA Shohei, OBA Takaaki, ITO Ken-ichi, KOMATSU Mitsuhisa

Retroperitoneal Schwannoma with Vertebral Body Compression Whose Diagnosis and Treatment Policy were Confirmed by CT-guided Needle Biopsy
The Shinshu Medical Journal,70(3):183-188 2022(Jun.)
Author:SHIMADA Yasuho, KUBOTA Satoshi, TAKAYAMA Shohei, SATO Yoshinori, KOBAYASHI Shota, KOMATSU Mitsuhisa

Exploring Hidden Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus Admitted to Shinshu University Hospital
The Shinshu Medical Journal,69(2):75-81 2021(Apr.)
Author:Sekido Keiko, Sekido Takashi, Ohkubo Yohsuke, Shibata Yusuke, Kawata Iori, Yamaguchi Tomohiko, Sato Ai, Sato Yoshihiko, Komatsu Mitsuhisa

Aldosterone to Potassium Ratio after Adrenocorticotropin Stimulation in Unilateral Primary Aldosteronism Diagnosis
The Shinshu Medical Journal,68(3):159-168 2020(Jun. 10)
Author:Kitahara, Junichiro; Ohkubo, Yousuke; Kitajima, Kouhei; Nishio, Shin-ichi; Oiwa, Ako; Sato, Ai; Yamazaki, Masanori; Sakuma, Takahiro; Sano, Asami; Nishii, Yutaka; Komatsu, Mitsuhisa

Loss of μ-crystallin causes PPARγ activation and obesity in high-fat diet-fed mice
Biochem Biophys Res Commun,508(3):912-920 2019
Author:Ohkubo Y, Sekido T, Nishio SI, Sekido K, Kitahara J, Suzuki S, Komatsu K.

Analysis for the Improvement of Inadequate Glycemic Control in Patients with Type 2 Diabetes Mellitus in Nagano, Japan
The Shinshu Medical Journal,66(5):319-324 2018(Oct. 10)
Author:Sato Ai, Sato Yoshihiko, Kobayashi Yuki, Yamazaki Masanori, Komatsu Mitsuhisa

Long-term Effects of Ipragliflozin on Adipose Tissue in Japanese Patients with Obese Type 2 Diabetes
The Shinshu Medical Journal,66(1):29-37 2018(Feb. 10)
Author:Nishio Shin-ichi,　Sekido Takashi,　Ohkubo Yohsuke,　Oiwa Ako,　Komatsu Mitsuhisa

Two Cases of Primary Biliary Cholangitis with Hepatocellular Carcinoma in a Non-cirrhotic Stage
The Shinshu Medical Journal,66(1):39-49 2018(Feb.)
Author:SUGIURA Ayumi, JOSHITA Satoru, YAMASHITA Yuki, KIMURA Takefumi, YAMAZAKI Tomoo, FUJIMORI Naoyuki, KOMATSU Michiharu, MATSUMOTO Akihiro, KOBAYASHI Shota, UMEMURA Takeji, TANAKA Eiji

Careful readings for a flash glucose monitoring system in nondiabetic Japanese subjects: individual differences and discrepancy in glucose concentrarion after glucose loading
Endocr J. ,64(8):827-832 2017
Author:Sekido K, Sekido T, Kaneko A, Hosokawa M, Sato A, Sato Y, Yamazaki M, Komatsu M

Lixisenatide improves glycemic outcomes of Japanese patients with type 2 diabetes: a meta-analysis.
Diabetol Metab Syndr. ,8:36 2016
Author:Seino H, Onishi Y, Naito Y, Komatsu M.

The Ratio of Plasma Aldosterone Concentration to Potassium in Adrenocorticotropin Stimulation Test is a Possible New Index for Diagnosis of Aldosterone-producing Adenoma in Patients with Primary Aldosteronism
The Shinshu Medical Journal,63(3):145-156 2015(Jun. 10)
Author:ISHII, Hiroaki; KOBAYASHI, Yuki; SHIBATA, Yusuke; MIYAKOSHI, Takahiro; MIYAKOSHI, Wakana; KITAHARA, Jun-ichiro; KATO, Kousuke; YOKOTA, Naokazu; KAWAI, Yuko; KOMATSU, Mitsuhisa

Case report: Beneficial effect of 11β-hydroxylase inhibitor in the management of an elderly patient with an androgen-producing inoperable adrenal tumor.
Geriatr Gerontol Int,13:509-511 2013
Author:Ozawa W, Sato K, Miyakoshi T, Nishio S, Yamazaki M, Suzuki S, Komatsu M

Possible roles of the AP-1 site in the cytosolic T3 binding protein promoter and insights into its physiological significance.
Horm Metab Res,45:501-506 2013
Author:Suzuki S, Nishio SI, Ishii H, Sekido T, Takeshige K, Ohkubo Y, Hiwatashi D, Takeda T, Komatsu M

Clinical features of a new disease concept, IgG4-related thyroiditis.
Scand J Rheumatol.,42:325-330 2013
Author:Watanabe T, Maruyama M, Ito T, Fujinaga Y, Ozaki Y, Maruyama M, Kodama R, Muraki T, Hamano H, Arakura N, Kadoya M, Suzuki S, Komatsu M, Shimojo H, Notohara K, Uchida M, Kawa S.

A new experimental model of ATP-sensitive K+ channel-independent insulinotropic action of glucose: a permissive role of cAMP for triggering of insulin release from rat pancreatic β-cells.
Endocr J,60:599-607 2013
Author:Takei M, Dezaki K, Ishii H, Nishio S, Sato Y, Suzuki S, Yada T, Komatsu M.

Humoral hypercalcemia associated with gastric carcinoma secreting parathyroid hormone: a case report and review of the literature.
Endocr J,60:557-562 2013
Author:Nakajima K, Tamai M, Okaniwa S, Nakamura Y, Kobayashi M, Niwa T, Horigome N, Ito N, Suzuki S, Nishio S, Komatsu M

Glucose-stimulated insulin secretion: A newer perspective.
J Diabetes Invest,4:511-516 2013
Author:Komatsu M

Gender-specific regulation of response to thyroid hormone in aging
Thyroid Res,5:1 2012(Jan. 26)
Author:Suzuki S, Nishio S, Takeda T, Komatsu M

Availability of self-recorded axillary temperature for assessmentof thermic effects of food: relationship between HDL-cholesterol level and postprandial thermoregulation in type 2 diabetic patients.
Exp Clin Endocrinol Diabetes,120:96-100 2012(Jan. 09)
Author:Suzuki S, Nishio SI, Ishii H, Sato A, Takeda T, Komatsu M

A Case of Severe and Recurrent Painless Thyroiditis Requiring Thyroidectomy.
Med Princ Pract,22:408-410 2012
Author:Ishii H, Takei M, Sato Y, Ito T, Ito KI, Sakai Y, Wataru Y, Suzuki S, Komatsu M

Amiodarone-induced thyrotoxicosis with thyroid papillary cancer in multinodular goiter: case report
Med Princ Pract,21:190-192 2011(Nov. 17)
Author:Inaba H, Suzuki S, Takeda T, Kobayashi S, Akamizu T, Komatsu M

Glucose-incretin interaction revisited.
Endocrine Journal,58(7):519-525 2011(Jan. 23)
Author:Ishii H, Sato Y, Takei M, Nishio S, Komatsu M

Transient polyuria related to central diabetes insipidus caused by lymphocytic infundibulo-neurohypophysitis in a patient treated for Graves'disease
Intern Med,49:1885-1890 2010(Sep. 01)
Author:Yamazaki M, Sato A, Nishio S, Uehara T, Komatsu M

Cold-induced sweating syndrome with neonatal features of Crisponi syndrome: longitudinal observation of a patient homozygous for a CRLF1 mutation
Am J Med Genet A,152A:764-769 2010(Mar.)
Author:Yamazaki M, Kosho T, Kawachi S, Mikoshiba M, Takahashi J, Sano R, Oka K, Yoshida K, Watanabe T, Kato H, Komatsu M, Kawamura R, Wakui K, Knappskog PM, Boman H, Fukushima Y

Distinct Clinical Courses in Type 1 Diabetes Mellitus Induced by Peg-interferon-alpha Treatment for Chronic Hepatitis C
INTERNAL MEDICINE,49(5):403-407 2010
Author:Yamazaki, Masanori; Sato, Ai; Takeda, Teiji; Komatsu, Mitsuhisa

Enhancement of the incretin pathway in response to bariatric surgery is important for restoration of beta cell function
DIABETOLOGIA,42(2):374-375 2009
Author:Komatsu, M; Aizawa,T

Development, worsening, and improvement of diabetic microangiopathy in older people: Six-year prospective study of patients under intensive diabetes control
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY,55(4):541-547 2007
Author:Katakura, M; Naka, M; Kondo, T; Komatsu, M; Yamauchi, K; Hashizume, K; Aizawa, T

経口薬を併用でうまく使う
プラクテイス,22:303-308 2005
Author:青木雄次，片倉正文，駒津光久，近藤照貴，仲元司，山内恵史，相澤　徹

Correlation between the Pituitary Size and Function in Patients with Asthenia
Endocr J,52:441-444 2005
Author:Yamada T, Nojiri K, Sasazawa H, Tsukui T, Miyahara Y, Nakayama K, Komatsu M, Aizawa T, Komiya I

Development, progression, and regression of microalbuminuria in Japanese patients with type 2 diabetes under tight glycemic and blood pressure control: the Kashiwa study
Diabetes Care,28:2733-2738 2005
Author:Yamada T, Komatsu M, Komiya I, Miyahara Y, Shima Y, Matsuzaki M, Ishikawa Y, Mita R, Fujiwara M, Furusato N, Nishi K, Aizawa T

Rab27a: a new face in beta cell metabolism-secretion coupling
J Clin Invest,115:227-230 2005
Author:Aizawa T, Komatsu M

Suppression of expression of muscle-associated proteins by PPARalpha in brown adipose tissue
Biochem Biophys Res Commun,336:76-83 2005
Author:Tong Y, Hara A, Komatsu M, Tanaka N, Kamijo Y, Gonzalez FJ, Aoyama T

糖尿病と蛋白のアシル化
内分泌・糖尿病科,18:338-343 2004
Author:駒津光久，相澤　徹

リンパ球性漏斗神経下垂体炎による中枢性尿崩症にステロイドが奏功した1例
ホルモンと臨床　増刊号「内分泌興味ある症例　第45集」,52:17-20 2004
Author:稲葉秀文，山内恵史，片井みゆき，武田貞二，駒津光久，橋爪潔志

加齢に伴う耐糖能低下のメカニズム
内分泌・糖尿病科,19:569-579 2004
Author:相澤　徹，駒津光久

Primacy of beta-cell dysfunction in the development of hyperglycemia: a study in the Japanese general population
Metabolism,53:949-953 2004
Author:Katakura M, Komatsu M, Sato Y, Hashizume K, Aizawa T

シンポジウムI　２１世紀の糖尿病療養ー人間ドック、健診の果たす役割ー
健康医学ー日本人間ドック学会誌ー,17(4):487-514 2003
Author:橋爪潔志、西澤啓治、岡山明、駒津光久、出浦照國、笹岡利安、前田亮

重症の糖尿病性網膜症を有する患者の内科的管理の注意点
糖尿病診療のコツと落とし穴.　河盛隆造編,:30 2003
Author:駒津光久

＜＜2型糖尿病では何が起こっているか＞＞膵β細胞ーインスリン初期分泌の低下とは
内科,9(1):35-39 2003
Author:駒津光久、相澤徹

血糖値1556 mg/dlでありながらケトアシドーシス、非ケトン性高浸透圧性昏睡を呈さなかった糖尿病の１例
糖尿病,46:437-440 2003
Author:佐藤吉彦、駒津光久、上原由美子、相澤徹、橋爪潔志

Prospective analysis of mortality, morbidity, and risk factors in elderly diabetics Nagano study.
Diabetes Care,26:638-644 2003
Author:M Katakura, M Naka, T Kondo, N Nishii, M Komatsu, Y Sato,K Yamauchi, K Hiramatsu, M Ikeda, T Aizawa, K Hashizume

Nutrient modulation of palmitoylated 24-kDa protein in rat pancreatic islets
Endocrinology,144:5232-5241 2003
Author:S Yamada, M Komatsu, Y Sato, K Yamauchi, T Aizawa, I Kojima

日本人のインスリン分泌の特徴ﾑ欧米人との違いー
Mebio別冊軽症２型糖尿病の治療戦略,:56-62 2002
Author:相澤徹、佐藤吉彦、駒津光久、片倉正文、大房裕和

インスリン分泌におけるKATPチャネル非依存性経路の役割
糖尿病ナビゲーター　メディカルレビュー社,:36-37 2002
Author:佐藤吉彦、駒津光久、相澤徹

高齢期における糖尿病多発の機序
Diabetes Frontier,13:321-325 2002
Author:相澤徹、片倉正文、駒津光久、山内恵史、橋爪潔志

Importance of nonionic signals for glucose-induced biphasic insulin secretion
Diabetes,51(Suppl 1):S96-S98 2002
Author:T Aizawa, Y Sato, M Komatsu

Triggering ofinsulin release by a combination of cAMP signal and nutrients: an ATP sensitive K+ channel-independent phenomenon
Diabetes,51(Suppl 1):S29-S32 2002
Author:M Komatsu, Y Sato, S Yamada, K Yamauchi, K Hashizume, T Aizawa

Diminution of early insulin response to glucose in subjects with normal but minimally elevated fasting plasma glucose. Evidence for early beta-cell dysfunction
Diabetic Medicine,19:566-571 2002
Author:Y Sato, M Komatsu, M Katakura, H Ohfusa, S Yamada, K Yamauchi, K Hiramatsu, K Ichikawa, T Aizawa, K Hashizume

A problem with the diagnosis of diabetes mellitus based on fasting plasma glucose
Diabetic Medicine,19:82-83 2002
Author:Y Sato, H Ohfusa, M Katakura, M Komatsu, S Yamada, K Yamauchi, K Ichikawa, T Aizawa, K Hashizume

The effects of cerulenin, an inhibitor of protein acylation, on the two phases of glucose-stimulated insulin secretion
Diabetes,51:S91-S95 2002
Author:SG Straub, H Yajima, M Komatsu, T Aizawa, GWG Sharp

Time-dependent potentiation of the beta-cell is aCa2+-independent phenomenon
Journal of Endocrinology,172:345-354 2002
Author:S Yamada, M Komatsu, T Aizawa, Y Sato, H Yajima, T Yada, S Hashiguchi, K Yamauchi, K Hashizume

Time-dependent stimulation of insulin exocytosis by 3',5'-cyclic adenosine monophosphate in the rat islet beta-cell
Endocrinology,143:4203-4209 2002
Author:S Yamada, M Komatsu, Y Sato, K Yamauchi, I Kojima, T Aizawa, K Hashizume

インスリン分泌─最近の話題─
臨床透析,17:15-22 2001
Author:佐藤吉彦、駒津光久、相澤徹、橋爪潔志

ATP感受性Kチャネルを介さないインスリン分泌機構
岡芳知編、糖尿病学　診断と治療社,:50-63 2001
Author:駒津光久、相澤徹

妊娠後期に肝機能障害に伴い尿崩症様症状を呈した１例
日本産婦人科学会関東連合地方部会会報,38:47-53 2001
Author:芦田敬、岡賢二、北直子、高木靖、金井誠、小西郁生、吉沢要、駒津光久

Size-related and size-unrelated functional heterogeneity among pancreatic islets
Life Science,69:2627-2639 2001
Author:T Aizawa, T Kaneko, K Yamauchi, H Yajima, T Nishizawa,T Yada, H Matsukawa, M Nagai, S Yamada, Y Sato, M Komatsu, N Itoh, H Hidaka, Y Kajimoto, K Hashizume

KATP channel-independent glucose action: an elusive pathway in stimulus-secretion coupling of pancreatic ｧ-cell
Endocrine Journal,48:275-288 2001
Author:M Komatsu, Y Sato, T Aizawa, K Hashizume

Norepinephrine inhibits glucose-stimulated, Ca2+-independent insulin release independently from its action on adenylyl cyclase
Endocrine Journal,48:647-654 2001
Author:H Yajima, M Komatsu, Y Sato, S Yamada, K Yamauchi, GWG Sharp, T Aizawa, K Hashizume

Glutamate is not a major conveyer of ATP-sensitive K+ channel-independent glucose action in pancreatic islet beta cell
Endocrine Journal,48:391-395 2001
Author:S Yamada, M Komatsu, Y Sato, K Yamauchi, T Aizawa, K Hashizume

Treatment of type 2 diabetes: the sooner, the better
J Intern Med,250:255-257 2001
Author:T Yamada, M Komatsu, Y Sato, I Komiya, K Yamauchi, T Aizawa, K Hashizume

Effects of nipradilol, a nitric oxide-releasing beta-adrenoceptor blocking agent, on phosphoenolpyruvate carboxykinase gene transcription in a rat hepatoma cell line
Jpn J Pharmacol,87:83-85 2001
Author:K Yamauchi, K Nakajima, S Ikeo, Y Nishimura, M Komatsu, T Aizawa, K Hashizume

膵β細胞とインスリンシグナリング
Mebio　別冊　Multiple Risk Factorと高血圧,:128-134 2000
Author:山内恵史、駒津光久、相澤徹、橋爪潔志

ブドウ糖によるインスリン分泌刺激ーtriggeringとaugmentationを区別する視点からのoverview-
医学のあゆみ,192:359-364 2000
Author:相澤徹、佐藤吉彦、駒津光久

ブドウ糖による膵β細胞からのインスリン分泌機構ーATP感受性K+チャネルの閉鎖を介さないインスリン分泌刺激機構の解明ー
上原記念生命科学財団研究報告集,14:305-307 2000
Author:駒津光久

Selective attenuation of metabolic branch of insulin receptor down-signaling byhigh glucose in a hepatoma cell line, HepG2 cells
J Biol Chem,275(27):20880-20886 2000
Author:K Nakajima, K Yamauchi, S Shigematsu, S Ikeo, M Komatsu, T Aizawa, K Hashizume

Rapidoscillation of insulin release by the rat pancreatic islets under stringent Ca2+-free conditions
Journal of Endocrinology,166(3):545-551 2000
Author:T Aizawa, T Kaneko, H Yajima, S Yamada, Y Sato, Y Kanda, S Kanda, M Noda, T Kadowaki, M Nagai, K Yamauchi, M Komatsu, K Hashizume

Importance of hypercoagulability over hyperglycemia for vascular complication in type 2 diabetes
Diabet Res Clin Pract,49(1):23-31 2000
Author:T Yamada, A Sato, T Nishimori, T Mitsuhashi, A Terao, H Sagai, M Komatsu, T Aizawa, K Hashizume

Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: A study in rat pancreatic islets
Diabetes,49(5):712-717 2000
Author:H Yajima, M Komatsu, S Yamada, SG Straub, T Kaneko, Y Sato, K Yamauchi, K Hashizume, GWG Sharp, T Aizawa

ブドウ糖によるインスリン分泌機構における脂質メッセンジャーの役割
Peptide Hormones in Pancreas,19:60-64 1999
Author:山田聡子、駒津光久、矢島博樹、金子剛、山内恵史、相澤徹、橋爪潔志

ブドウ糖によるCa2+非依存性インスリン分泌刺激
内分泌、糖尿病科,9:510-520 1999
Author:駒津光久

糖尿病病型分類の問題点
糖尿病学１９９９．小坂樹徳編,:49-60 1999
Author:相澤徹、片倉正文、駒津光久、山内恵史、橋爪潔志

インスリン分泌促進薬
Diabetes Frontier,10:826-830 1999
Author:相澤徹、駒津光久、橋爪潔志

Long-term prognosis of islet cell antibody-negative ketosis-onset diabetes with subsequent non-insulin dependency
Diabetes Care,22(9):1584-1586 1999
Author:M Katakura, T Aizawa, M Naka, Y Funase, M Komatsu, K Yamauchi, K Yoshizawa, K Hashizume

CAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets
Diabetes,48(5):1006-1012 1999
Author:H Yajima, M Komatsu, T Shermerhorn, T Aizawa, T Kaneko, M Nagai, GWG Sharp, K Hashizume

Augmentation of Ca2+-Stimulated Insulin Release by Glucose and Long Chain Fatty Acids in Rat Pancreatic Islets: Free Fatty Acids Mimic ATP-Sensitive K+ Channel-Independent Insulinotropic Action of Glucose
Diabetes,48(8):1543-1549 1999
Author:M Komatsu, H Yajima, S Yamada, T Kaneko, Y Sato, K Yamauchi, K Hashizume, T Aizawa

Functional heterogeneity of pancreatic islets.
DIABETOLOGIA,41:A149-A149 1998
Author:Aizawa, T; Kaneko, T; Komatsu, M; Yajima, H; Nagai, M; Yamauchi, K; Hashizume, K

自然発症糖尿病モデル動物における高濃度ブドウ糖の膵b細胞priming作用
Peptide Hormones in Pancreas,18:48-52 1998
Author:相澤徹、鈴木尚美、麻沼奈穂子、寺内康夫、駒津光久、山内恵史、門脇孝、橋爪潔志

膵B細胞のインスリン分泌機構におけるプロテインキナーゼAのdistal effect
Peptide Hormones in Pancreas,18:106-111 1998
Author:矢島博樹、駒津光久、相澤徹、永井稔、金子剛、山内恵史、橋爪潔志

耐糖能異常
Mebio別冊 Multiple risk factor syndrome 2. インスリン抵抗性の位置づけ,:62-67 1998
Author:相澤徹、駒津光久、山内恵史、橋爪潔志

高齢者における橋本病の特徴
日本老年医学会雑誌,35:771-776 1998
Author:市川和夫、金子剛、鈴木悟、駒津光久、山内恵史、相澤徹、橋爪潔志

ケトーシスで発症し膵島抗体陰性の糖尿病患者の長期予後
糖尿病,41(suppl):A115-A117 1998
Author:片倉正文、相澤徹、駒津光久、山内恵史、仲元司、吉澤國雄、橋爪潔志

Risk factors determining mortality in older diabetics: a pilot study in Japanese patients
J Am Geriatr Soc,46(4):538-540 1998
Author:T Aizawa, S Shigematsu, K Hiramatsu, M Komatsu, K Yamauchi, T Kaneko, K Hashizume

Nutrient augmentation of Ca2+-dependent and Ca2+-independent pathways in stimulus-coupling to insulin secretion can be distinguished by their guanosine triphosphate requirements:studies on rat pancreatic islets
Endocrinology,139:1172-1183 1998
Author:M Komatsu, M Noda, GWG Sharp

Palmitate and myristate selectively mimic the effect ofglucose in augmenting insulin release in the absence of extracellular Ca2+
Diabetes,47(3):352-357 1998
Author:M Komatsu, GWG Sharp

Glucose action'beyond ionic events'in the pancreatic beta cell
Trends. Pharmacol. Sci,19(12):496-499 1998
Author:T Aizawa, M Komatsu, N Asanuma, Y Sato, GWG Sharp

Goto-Kakizaki rat, a model of glucose priming rather than glucose toxicity?
DIABETOLOGIA,40:452-452 1997
Author:Suzuki, N; Aizawa, T; Asanuma, N; Komatsu, M; Hashizume, K

Two signaling pathways, from the upper glycolytic flux and from the mitochondria, converge to potentiate insulin release
Endocrinology,138(2):751-755 1997
Author:N Asanuma, T Aizawa, Y Sato, T Schermerhorn, M Komatsu, GWG Sharp, K Hashizume

An early insulin intervention accelerates pancreatic beta-cell dysfunction in young Goto-Kakizaki rats, a model of naturally occurring noninsulin-dependent diabetes
Endocrinology,138(3):1106-1110 1997
Author:N Suzuki, T Aizawa, N Asanuma, Y Sato, M Komatsu, H Hidaka, N Itoh, K Yamauchi, K Hashizume

Augmentation of insulin release by glucose in the absence of extracellular Ca2+: New insights into stimulus-secretion coupling
Diabetes,46(12):1928-1938 1997
Author:M Komatsu, T Schermerhorn, M Noda, SG Straub, T Aizawa, GWG Sharp

Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene
Biochem Biophys Res Commun,229(2):460-465 1996
Author:T Aizawa, N Asanuma, Y Terauchi, N Suzuki, M Komatsu, N Itoh, T Nakabayashi, H Hidaka, H Ohnota, K Yamauchi, K Yasuda, Y Yazaki, T Kadowaki, K Hashizume

The betaHC9 pancreatic beta cell line preserves the characteristics of the progenitor mouse islets
Diabetes,45:1766-1773 1996
Author:M Noda, M Komatsu, GWG Sharp

Pituitary adenylate cyclase-activating peptide, carbachol and glucose stimulate insulin release in the absence of an increase in intracellular Ca2+
Mol Pharmacol,50:1047-1054 1996
Author:M Komatsu, T Schermerhorn, SG Straub, GWG Sharp

Mastoparan increases [Ca2+]i by inhibition of the ATP-sensitive potassium channel intwo insulin-secreting cell lines
Mol Pharmacol,47:787-797 1995
Author:GT Eddlestone, M Komatsu, L Shen, GWG Sharp

Time course of action of pertussis toxin to block theinhibition of stimulated insulin release by norepinephrine
Endocrinology,136:1857-1863 1995
Author:M Komatsu, AM McDermott, SL Gillison, GWG Sharp

Sodium fluoride stimulates exocytosis at a late site of calcium interaction in stimulus-secretion coupling: studies with the RINm5F beta-cell line
Mol Pharmacol,47:496-508 1995
Author:M Komatsu, AM McDermott, GWG Sharp

Glucose stimulation of insulin release in the absence of extracellular Ca2+ and in the absence of any increase in intracellular Ca2+ in rat pancreatic islets
Proc Natl Acad Sci U S A,92(23):10728-10732 1995
Author:M Komatsu, T Schermerhorn, T Aizawa, GWG Sharp

ATP-sensitive K+ channel-independent glucose action in rat pancreatic beta-cell
Am J Physiol,266(3):C622-C627 1994
Author:T Aizawa, Y Sato, F Ishihara, N Taguchi, M Komatsu, N Suzuki, K Hashizume, T Yamada

Insulin secretion by the pancreatic beta cell of aged rats
Pancreas,9(4):454-459 1994
Author:T Aizawa, M Komatsu, Y Sato, F Ishihara, N Suzuki, N Nishii, K Hashizume, T Yamada

Possible link between a low prevalence of cardiovascular disease and mild dyslipidaemia: a study in Japanese patients with type 2 diabetes
Diabetic Medicine,10(5):431-437 1993
Author:T Aizawa, M Kobayashi, Y Sato, M Tozuka, F Ishihara, N Okada, S Shigematsu, M Komatsu, K Hiramatsu, K Yamauchi, I Komiya, T Yamada, M Kanai, Z Honda

Role of dehydroepiandrosterone and dehydroepiandrosterone sulfate for the maintenance of axillary hair in women
Horm Metab Res,25(1):34-36 1993
Author:F Ishihara, M Komatsu, T Yamada, T Aizawa, K Ichikawa, N Takasu, I Komiya

Mastoparan stimulates exocytosis at a Ca2+-independent late site in stimulus secretion coupling. Studies with the RINm5F beta-cell line
J Biol Chem,268:23297-23306 1993
Author:M Komatsu, AM McDermott, SL Gillison, GWG Sharp

10-YEAR FOLLOW-UP OF JAPANESE OVERWEIGHT SUBJECTS WITH IMPAIRED GLUCOSE-TOLERANCE - IDENTIFICATION OF A DIABETES-PRONE SUBPOPULATION
INTERNAL MEDICINE,31(7):877-884 1992
Author:YAMADA, T; AIZAWA, T; NAGASAWA, Y; ISHIHARA, M; KOMATSU, M; KOMIYA, I; SHINODA, T; TAKASU, N

ATP-sensitive K+channel-independent, insulinotropic action of glucose in the B-cells
Endocrine Regulation,26:159-170 1992
Author:T Aizawa, Y Sato, M Komatsu, K Hashizume

A case of autoimmune insulin antibody syndrome associated with polymyositis, empty sella and apparant high urinary output of immunoreactive insulin
ENDOCRINOLOGIA JAPONICA,39(3):307-313 1992
Author:K Ichikawa, Y Nishii, K Hashizume, M Chino, T Nagasawa, S Suzuki, N Okada, M Kobayashi, Y Koizumi, M Arai, M Komatsu, T Aizawa, T Asawa, F Ishihara, T Yamada

Mastoparan-induced hormone release from rat pancreatic islets
Endocrinology,130(1):221-228 1992
Author:M Komatsu, T Aizawa, N Yokokawa, Y Sato, N Okada, N Takasu, T Yamada

Abnormal molecular weight profile of urinary protein in rats with streptozotocin-induced diabetes
Diabet Res Clin Pract,18(1):1-9 1992
Author:N Okada, T Aizawa, N Yokokawa, M Kobayashi, T Moriya, S Shigematsu, T Shirota, M Komatsu, T Shinoda, T Yamada, K Nakazawa, N Itoh, H Shigematsu

Differential effects of body weight, hyperinsulinemiaand oral glucose load on serum C-peptide/Insulin molar ratio
Horm Metab Res,24(9):429-433 1992
Author:N Okada, M Kobayashi, H Ohtsuka, S Shigematsu, Y Nagasawa, M Komatsu, T Aizawa, T Yamada

Dual functional role of membrane depolarization/Ca2+ influx in rat pancreatic B-cell
Diabetes,41(4):438-443 1992
Author:Y Sato, T Aizawa, M Komatsu, N Okada, T Yamada

Ten-year follow up of Japanese overweight subjects with impaired glucose tolerance: Identification of a diabetes-prone subpopulation
Int Med,31:887-884 1992
Author:T Yamada, T Aizawa, Y Nagasawa, M Ishihara, M Komatsu, I Komiya, T Shinoda, N Takasu

Gradual delay in glucose-induced first phase insulin secretion by the pancreatic islets of 7 week-, 6 month-, and 1 year-old rats
J Gerontol,46(2):B59-B64 1991
Author:M Komatsu, N Yokokawa, Y Nagasawa, I Komiya, T Aizawa, N Takasu, T Yamada

Unusual clinical presentation of malignant histiocytosis in a 70-year-old woman
J Int Med,230(1):73-77 1991
Author:M Komatsu, M Katakura, T Aizawa, Y Yukimura, T Yamada, H Saito, S Furuta, N Ito, Y Onishi

Dipyridamole reduces urinary albumin excretion in diabetic patients with normo- or microalbuminuria
Clin Nephrol,33(3):130-135 1990
Author:T Aizawa, S Suzuki, T Asawa, M Komatsu, S Shigematsu, N Okada, M Katakura, K Hiramatsu, T Shinoda, K Hashizume, N Takasu, T Yamada, Y Masaoka, M Mimura, H Takahashi, K Shimizu, Z Honda

ACTH deficiency and TSH hypersecretion in a patient with empty sella turcica
Am J Med Sci,296:186-189 1989
Author:M Komatsu, T Aizawa, T Shinoda, T Yamada, T Mochizuki

Glucose raises cytosolic free calcium in the rat pancreatic islets
Horm Metab Res,21:405-409 1989
Author:M Komatsu, T Aizawa, N Takasu, T Yamada

Pharmacological characterizationof the voltage-dependent calcium channel of pancreaic B-cell
Endocrinology,125:2008-2014 1989

Intestinal pseudo-obstruction due to dialysis amyloidosis
Clin Nephrol,32:284-289 1989
Author:T Shinoda, M Komatsu, T Aizawa, T Shirota, T Yamada, T Ehara, E Mizukami

Mastoparan, a wasp venom, stimulates insulin release by pancreatic islets through pertussis toxin sensitive GTP-binding protein
Biochem Biophys Res Commun 1989
Author:N Yokokawa, M Komatsu, T Takeda, T Aizawa, T Yamada

インスリン分泌の分子機構．G蛋白シグナルとインスリン分泌機構　ATP感受性K+ チャネルを介さないブドウ糖によるインスリン分泌刺激
分子糖尿病学の進歩１９９８金原出版,:4-10 1988
Author:駒津光久、相澤徹、橋爪潔志

Antipituitary antibody in patients with the primary empty sella syndrome
J Clin Endocrinol Metab,67:633-638 1988
Author:M Komatsu, T Kondo, K Yamauchi, N Yokokawa, K Ichikawa, M Ishihara, T Aizawa, T Yamada, Y Imai, K Tanaka, K Taniguchi, T Watanabe, Y Takahashi

Hydrogen peroxide generation in whole rat pancreatic islet; synergistic regulation by cytoplasmic free calcium and protein kinase-C
Biochem Biophys Res Commun,155 1988
Author:N Takasu,M Komatsu, T Aizawa, T Yamada

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KOMATSU MITSUHISA

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KOMATSU　MITSUHISA