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梅村武司  ウメムラ タケジ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 内科学第二FAX番号
職名准教授メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

更新日:2017/10/19

プロフィール

研究分野
消化器病学
肝臓病学
所属学会
所属学会
日本肝臓学会
日本消化器病学会

所属学会役職担当
日本肝臓学会 , 評議員
日本消化器病学会 , 評議員
学歴
出身大学院
2001 , 信州大学

出身学校・専攻等(大学院を除く)
1994 , 信州大学

取得学位
医学博士 , 信州大学
受賞学術賞
2015 , 加藤記念難病研究助成基金
2008 , 信州大学医学部松医会賞臨床部門
2007 , 信州大学若手萌芽研究助成
2007 , 膵臓病研究財団研究助成
2006 , 日本消化器病学会研究助成
2006 , 日本肝臓学会第5回 Schering-Plough-Award
2005 , ウイルス肝炎研究財団研究助成
研究職歴等
研究職歴
2012- , 准教授
2010- , 信州大学医学部附属病院 講師
2008- , 信州大学医学部消化器内科 助教
2006- , 信州大学医学部附属病院消化器内科 診療助手
1994- , 信州大学第二内科研修医

留学歴
1998- , 米国国立衛生研究所輸血部研究員

研究活動業績

研究業績(著書・
発表論文等)
論文
Association between lower air pressure and the onset of ischemic colitis: a case-control study
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY,29(9):1071-1078 2017(Sep.)
Author:Kimura, Takefumi; Shinji, Akihiro; Tanaka, Naoki; Koinuma, Masayoshi; Yamaura, Maki; Nagaya, Tadanobu; Joshita, Satoru; Komatsu, Michiharu; Umemura, Takeji; Horiuchi, Akira; Wada, Shuichi; Tanaka, Eiji;


Association between serum soluble CD14 and IL-8 levels and clinical outcome in primary biliary cholangitis
LIVER INTERNATIONAL,37(6):897-905 2017(Jun.)
Author:Umemura, Takeji; Sekiguchi, Tomohiro; Joshita, Satoru; Yamazaki, Tomoo; Shibata, Soichiro; Ichikawa, Yuki; Komatsu, Michiharu; Matsumoto, Akihiro; Shums, Zakera; Norman, Gary L.; Tanaka, Eiji; Ota, Masao;


インターフェロン,核酸アナログ製剤の選択 : 適応と治療の実際 (特集 B型・C型肝炎の最新治療戦略 : どの治療を選択すべきか) -- (B型肝炎)
消化器の臨床,20(1):20-23 2017(Feb.)
Author:梅村 武司;
Keywords:HBV; Peg-IFN; 核酸アナログ;


Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein may predict liver fibrosis and progression to hepatocellular carcinoma in patients with chronic hepatitis B virus infection
HEPATOLOGY RESEARCH,47(2):226-233 2017(Feb.)
Author:Ichikawa, Yuki; Joshita, Satoru; Umemura, Takeji; Shobugawa, Yugo; Usami, Yoko; Shibata, Soichiro; Yamazaki, Tomoo; Fujimori, Naoyuki; Komatsu, Michiharu; Matsumoto, Akihiro; Tanaka, Eiji;


Immunogenetics of IgG4-Related AIP
IGG4-RELATED DISEASE,401:35-44 2017
Author:Ota, Masao; Umemura, Takeji; Kawa, Shigeyuki;


Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population
HUMAN MOLECULAR GENETICS,26(3):650-659 2017
Author:Kawashima, Minae; Hitomi, Yuki; Aiba, Yoshihiro; Nishida, Nao; Kojima, Kaname; Kawai, Yosuke; Nakamura, Hitomi; Tanaka, Atsushi; Zeniya, Mikio; Hashimoto, Etsuko; Ohira, Hiromasa; Yamamoto, Kazuhide; Abe, Masanori; Nakao, Kazuhiko; Yamagiwa, Satoshi; Kaneko, Shuichi; Honda, Masao; Umemura, Takeji; Ichida, Takafumi; Seike, Masataka; Sakisaka, Shotaro; Harada, Masaru; Yokosuka, Osamu; Ueno, Yoshiyuki; Senju, Michio; Kanda, Tatsuo; Shibata, Hidetaka; Himoto, Takashi; Murata, Kazumoto; Miyake, Yasuhiro; Ebinuma, Hirotoshi; Taniai, Makiko; Joshita, Satoru; Nikami, Toshiki; Ota, Hajime; Kouno, Hiroshi; Kouno, Hirotaka; Nakamuta, Makoto; Fukushima, Nobuyoshi; Kohjima, Motoyuki; Komatsu, Tatsuji; Komeda, Toshiki; Ohara, Yukio; Muro, Toyokichi; Yamashita, Tsutomu; Yoshizawa, Kaname; Nakamura, Yoko; Shimada, Masaaki; Hirashima, Noboru; Sugi, Kazuhiro; Ario, Keisuke; Takesaki, Eiichi; Naganuma, Atsushi; Mano, Hiroshi; Yamashita, Haruhiro; Matsushita, Kouki; Yamauchi, Kazuhiko; Makita, Fujio; Nishimura, Hideo; Furuta, Kiyoshi; Takahashi, Naohiro; Kikuchi, Masahiro; Masaki, Naohiko; Tanaka, Tomohiro; Tamura, Sumito; Mori, Akira; Yagi, Shintaro; Shirabe, Ken; Komori, Atsumasa; Migita, Kiyoshi; Ito, Masahiro; Nagaoka, Shinya; Abiru, Seigo; Yatsuhashi, Hiroshi; Yasunami, Michio; Shimoda, Shinji; Harada, Kenichi; Egawa, Hiroto; Maehara, Yoshihiko; Uemoto, Shinji; Kokudo, Norihiro; Takikawa, Hajime; Ishibashi, Hiromi; Chayama, Kazuaki; Mizokami, Masashi; Nagasaki, Masao; Tokunaga, Katsushi; Nakamura, Minoru;


Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis
JOURNAL OF IMMUNOLOGY RESEARCH,:- 2017
Author:Joshita, Satoru; Umemura, Takeji; Tanaka, Eiji; Ota, Masao;


Association between endotoxemia and histological features of nonalcoholic fatty liver disease
WORLD JOURNAL OF GASTROENTEROLOGY,23(4):712-722 2017
Author:Kitabatake, Hiroyuki; Tanaka, Naoki; Fujimori, Naoyuki; Komatsu, Michiharu; Okubo, Ayaka; Kakegawa, Kyogo; Kimura, Takefumi; Sugiura, Ayumi; Yamazaki, Tomoo; Shibata, Soichiro; Ichikawa, Yuki; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Koinuma, Masayoshi; Sano, Kenji; Aoyama, Toshifumi; Tanaka, Eiji;


Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non-alcoholic fatty liver disease with none-to-mild obesity and liver fibrosis
HEPATOLOGY RESEARCH,46(10):1019-1027 2016(Sep.)
Author:Fujimori, Naoyuki; Tanaka, Naoki; Shibata, Soichiro; Sano, Kenji; Yamazaki, Tomoo; Sekiguchi, Tomohiro; Kitabatake, Hiroyuki; Ichikawa, Yuki; Kimura, Takefumi; Komatsu, Michiharu; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji;


A Case of Esophageal Hemangioma Successfully Treated by Endoscopic Injection Sclerotherapy
信州医学雑誌,64(2):75-78 2016(Apr. 10)
Author:Suga Tomoaki, Okamura Takuma, Iwaya Yugo, Ito Tetsuya, Arakura Norikazu, Umemura Takeji, Tanaka Eiji


国内におけるde novo B型肝炎の実態と肝臓学会によるB型肝炎治療ガイドライン
血液内科,70(1):123-127 2015(Jan.)
Author:梅村 武司;
Keywords:HBV; de novo hepatitis; reactivation;


C型肝炎の新規治療法
信州医学雑誌,63(6):367-374 2015
Author:梅村 武司;
Keywords:C型肝炎ウイルス; インターフェロン; 直接作用型抗ウイルス薬; ウイルス学的著効;


KIR3DL1-HLA-Bw4 combination and IL28B polymorphism predict response to Peg-IFN and ribavirin with and without telaprevir in chronic hepatitis C
HUMAN IMMUNOLOGY,75(8):822-826 2014(Aug.)
Author:Umemura, Takeji; Ota, Masao; Katsuyama, Yoshihiko; Wada, Shuichi; Mori, Hiromitsu; Maruyama, Atsushi; Shibata, Soichiro; Nozawa, Yuichi; Kimura, Takefumi; Morita, Susumu; Joshita, Satoru; Komatsu, Michiharu; Matsumoto, Akihiro; Kamijo, Atsushi; Kobayashi, Masakazu; Takamatsu, Masato; Yoshizawa, Kaname; Kiyosawa, Kendo; Tanaka, Eiji


Laparoscopic findings of congenital hepatic fibrosis: A case report and review of the published work
HEPATOLOGY RESEARCH,44(7):818-824 2014(Jul.)
Author:Komatsu, Michiharu; Tanaka, Naoki; Shibata, So-Ichirou; Kimura, Takefumi; Ichikawa, Yuki; Morita, Susumu; Joshita, Satoru; Nagaya, Tadanobu; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Tanaka, Eiji


HLA CLASS II HAPLOTYPES AFFECT CLINICAL CHARACTERISTICS AND PROGRESSION OF TYPE 1 AUTOIMMUNE HEPATITIS IN JAPAN
TISSUE ANTIGENS,84(1):153-153 2014(Jul.)
Author:Umemura, Takeji; Yoshizawa, Kaname; Katsuyama, Yoshihiko; Tanaka, Eiji; Inoko, Hidetoshi; Ota, Masao


Human Leukocyte Antigen Class II Haplotypes Affect Clinical Characteristics and Progression of Type 1 Autoimmune Hepatitis in Japan
PLOS ONE,9(6) 2014(Jun. 23)
Author:Umemura, Takeji; Katsuyama, Yoshihiko; Yoshizawa, Kaname; Kimura, Takefumi; Joshita, Satoru; Komatsu, Michiharu; Matsumoto, Akihiro; Tanaka, Eiji; Ota, Masao


Risk Factors for Long-Term Persistence of Serum Hepatitis B Surface Antigen Following Acute Hepatitis B Virus Infection in Japanese Adults
HEPATOLOGY,59(1):89-97 2014(Jan.)
Author:Ito, Kiyoaki; Yotsuyanagi, Hiroshi; Yatsuhashi, Hiroshi; Karino, Yoshiyasu; Takikawa, Yasuhiro; Saito, Takafumi; Arase, Yasuji; Imazeki, Fumio; Kurosaki, Masayuki; Umemura, Takeji; Ichida, Takafumi; Toyoda, Hidenori; Yoneda, Masashi; Mita, Eiji; Yamamoto, Kazuhide; Michitaka, Kojiro; Maeshiro, Tatsuji; Tanuma, Junko; Tanaka, Yasuhito; Sugiyama, Masaya; Murata, Kazumoto; Masaki, Naohiko; Mizokami, Masashi; Japanese AHB Study Grp


共通生薬成分を含む漢方薬の再投与により薬物性肝障害再発をきたした1例
肝臓,55(4):214-220 2014
Author:丸山 康弘,吉澤 要,鶴田 史,丸山 雅史,藤森 一也,滋野 俊,福島 万奈,上原 剛,森田 進,城下 智,梅村 武司,田中 榮司
Abstract:症例は61歳,女性.めまいに対して柴苓湯を処方され,29日目に食欲不振,嘔気が出現し,肝胆道系酵素の著明な上昇を認め入院となった.ウイルス感染,自己免疫性肝疾患は否定的であり,病歴から薬物性肝障害を疑った.DDW-J 2004薬物性肝障害ワークショップのスコアリングでは9点であった.薬物リンパ球刺激試験(DLST)で柴苓湯が陽性となり,柴苓湯による肝障害の可能性が高いと判断した.グリチルリチン製剤投与で肝機能は改善した.1年半後,右季肋部痛に対して,柴胡桂枝湯を処方され,14日後に食欲不振,嘔気が出現し,再度の肝胆道系酵素の上昇のため入院となった.DDW-J 2004スコアリングでは11点であった.両漢方薬の共通生薬成分によるDLSTを行ったところ,オウゴン,カンゾウで陽性あり,これらの成分が肝障害に作用した可能性が示唆された.漢方薬による薬物性肝障害の既往歴がある際の漢方薬の投与は,成分を確認した上で慎重に行うべきである.


STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis
DISEASE MARKERS 2014
Author:Joshita, Satoru; Umemura, Takeji; Nakamura, Minoru; Katsuyama, Yoshihiko; Shibata, Soichiro; Kimura, Takefumi; Morita, Susumu; Komatsu, Michiharu; Matsumoto, Akihiro; Yoshizawa, Kaname; Ishibashi, Hiromi; Tanaka, Eiji; Ota, Masao


STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis
DISEASE MARKERS,2014:727393 2014
Author:Joshita, S; Umemura, T; Nakamura, M; Katsuyama, Y; Shibata, S; Kimura, T; Morita, S; Komatsu, M; Matsumoto, A; Yoshizawa, K; Ishibashi, H; Tanaka, E; Ota, M


KIR, HLA, and IL28B Variant Predict Response to Antiviral Therapy in Genotype 1 Chronic Hepatitis C Patients in Japan
PLOS ONE,8(12) 2013(Dec. 12)
Author:Nozawa, Yuichi; Umemura, Takeji; Joshita, Satoru; Katsuyama, Yoshihiko; Shibata, Soichiro; Kimura, Takefumi; Morita, Susumu; Komatsu, Michiharu; Matsumoto, Akihiro; Tanaka, Eiji; Ota, Masao


de novo B型肝炎のウイルス学的特徴 (特集 B型肝炎ウイルス再活性化の現状と対策)
消化器内科,57(5):624-626 2013(Nov.)
Author:梅村 武司


Cutaneous sarcoidosis in a chronic hepatitis C patient receiving pegylated interferon and ribavirin therapy
HEPATOLOGY RESEARCH,43(7):801-807 2013(Jul.)
Author:Joshita, Satoru; Shirahata, Kumiko; Yazaki, Yoshikazu; Okaniwa, Shinji; Nakamura, Yoshiyuki; Kimura, Takefumi; Noami, Sugiko; Horigome, Reiko; Yagi, Hikaru; Ito, Nobuo; Yamazaki, Asami; Akahane, Yuki; Umemura, Takeji; Yoshizawa, Kaname; Tanaka, Eiji; Ota, Masao


乳び腹水に対してオクトレオチド投与が有効であった子宮頸癌, 肝細胞癌合併C型肝硬変の1例
肝臓,54(4):284-290 2013(Apr. 25)
Author:齊藤 博美,城下 智,吉澤 要,藤森 芳史,丸山 康弘,伊藤 哲也,児玉 亮,横沢 秀一,小松 通治,梅村 武司,田中 榮司


本邦におけるde novo B型肝炎症例の背景と予後 (特集 B型肝炎再活性化の現状と対策 : 肝臓,血液,リウマチ,腫瘍領域の現状を踏まえて)
最新医学,68(3):351-354 2013(Mar.)
Author:梅村 武司


Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis
HUMAN IMMUNOLOGY,74(2):219-222 2013(Feb.)
Author:Morita, Susumu; Joshita, Satoru; Umemura, Takeji; Katsuyama, Yoshihiko; Kimura, Takefumi; Komatsu, Michiharu; Matsumoto, Akihiro; Yoshizawa, Kaname; Kamijo, Astushi; Yamamura, Nobuyoshi; Tanaka, Eiji; Ota, Masao


Liver Dysfunction and Thrombocytopenia Diagnosed as Intravascular Large B-cell Lymphoma Using a Timely and Accurate Transjugular Liver Biopsy
INTERNAL MEDICINE,52(17):1903-1908 2013
Author:Sekiguchi, Nodoka; Joshita, Satoru; Yoshida, Toshikazu; Kurozumi, Masahiro; Sano, Kenji; Nakagawa, Michitaka; Ito, Tetsuya; Matsushita, Tsuyoshi; Komatsu, Daisuke; Komatsu, Michiharu; Ito, Toshiro; Umemura, Takeji; Ikeda, Shu-ichi; Kadoya, Masumi; Ishida, Fumihiro; Tanaka, Eiji


Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population
AMERICAN JOURNAL OF HUMAN GENETICS,91(4):721-728 2012(Oct. 05)
Author:Nakamura, Minoru; Nishida, Nao; Kawashima, Minae; Aiba, Yoshihiro; Tanaka, Atsushi; Yasunami, Michio; Nakamura, Hitomi; Komori, Atsumasai; Nakamuta, Makoto; Zeniya, Mikio; Hashimoto, Etsuko; Ohira, Hiromasa; Yamamoto, Kazuhide; Onji, Morikazu; Kaneko, Shuichi; Honda, Masao; Yamagiwa, Satoshi; Nakao, Kazuhiko; Ichida, Takafumi; Takikawa, Hajime; Seike, Masataka; Umemura, Takeji; Ueno, Yoshiyuki; Sakisaka, Shotaro; Kikuchi, Kentaro; Ebinuma, Hirotoshi; Yamashiki, Noriyo; Tamura, Sumito; Sugawara, Yasuhiko; Mori, Akira; Yagi, Shintaro; Shirabe, Ken; Taketomi, Akinobu; Arai, Kuniaki; Monoe, Kyoko; Ichikawa, Tatsuki; Taniai, Makiko; Miyake, Yasuhiro; Kumagi, Teru; Abe, Masanori; Yoshizawa, Kaname; Joshita, Satoru; Shimoda, Shinji; Honda, Koichi; Takahashi, Hiroki; Hirano, Katsuji; Takeyama, Yasuaki; Harada, Kenichi; Migita, Kiyoshi; Ito, Masahiro; Yatsuhashi, Hiroshi; Fukushima, Nobuyoshi; Ota, Hajime; Komatsu, Tatsuji; Saoshiro, Takeo; Ishida, Jinya; Kouno, Hirotsugu; Kouno, Hirotaka; Yagura, Michiyasu; Kobayashi, Masakazu; Muro, Toyokichi; Masaki, Naohiko; Hirata, Keiichi; Watanabe, Yukio; Nakamura, Yoko; Shimada, Masaaki; Hirashima, Noboru; Komeda, Toshiki; Sugi, Kazuhiro; Koga, Michiaki; Ario, Keisuke;Takesaki, Eiichi; Maehara, Yoshihiko; Uemoto, Shinji; Kokudo, Norihiro; Tsubouchi, Hirohito; Mizokami, Masashi; Nakanuma, Yasuni; Tokunaga, Katsushi; Ishibashi, Hiromi


Long-term outcome of Japanese patients with type 1 autoimmune hepatitis
HEPATOLOGY,56(2):668-676 2012(Aug.)
Author:Yoshizawa, Kaname; Matsumoto, Akihiro; Ichijo, Tetsuya; Umemura, Takeji; Joshita, Satoru; Komatsu, Michiharu; Tanaka, Naoki; Tanaka, Eiji; Ota, Masao; Katsuyama, Yoshihiko; Kiyosawa, Kendo; Abe, Masanori; Onji, Morikazu


Changes in the serum level of hepatitis B virus (HBV) surface antigen over the natural course of HBV infection
JOURNAL OF GASTROENTEROLOGY,47(9):1006-13 2012
Author:Matsumoto A, Tanaka E, Morita S, Yoshizawa K, Umemura T, Joshita S


Long-term outcome of Japanese patients with type 1 autoimmune hepatitis.
HEPATOLOGY,56:668-76 2012
Author:Yoshizawa K, Matsumoto A, Ichijo T, Umemura T, Joshita S, Komatsu M, Tanaka N, Tanaka E, Ota M, Katsuyama Y, Kiyosawa K, Abe M, Onji M.


HLA class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis.
HEPATOLOGY,55:506-511 2012
Author:Umemura T, Joshita S, Ichijo T, Yoshizawa K, Katsuyama Y, Tanaka E, Ota M; The Shinshu PBC Study Group.


Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection.
Hum Immunol,73(3):298-300 2012
Author:Joshita S, Umemura T, Katsuyama Y, Ichikawa Y, Kimura T, Morita S, Kamijo A, Komatsu M, Ichijo T, Matsumoto A, Yoshizawa K, Kamijo N, Ota M, Tanaka E.


Occult HBV感染とその対応 (新時代のウイルス性肝炎学--基礎・臨床研究の進歩) -- (特殊な病態におけるB型肝炎に対する対応)
日本臨床,69:515-519 2011(May)
Author:梅村 武司


B型肝炎の発症機序と病態 (新時代のウイルス性肝炎学--基礎・臨床研究の進歩) -- (B型肝炎の病態)
日本臨床,69:417-421 2011(May)
Author:田中 榮司,松本 晶博,梅村 武司


Genetic background of autoimmune hepatitis in Japan
JOURNAL OF GASTROENTEROLOGY,46(1):42-47 2011(Jan.)
Author:Yoshizawa, Kaname; Umemura, Takeji; Ota, Masao


Serum IL-10 and IL-12p40 levels and IL28B gene polymorphisms: pretreatment prediction of treatment failure in chronic hepatitis C
Antiviral Therapy,16(7):1073-8 2011
Author:Umemura T, Joshita S, Yoneda S, Katsuyama Y, Ichijo T, Matsumoto A, Yoshizawa K, Ota M, Tanaka E.


Serum chemokine levels are associated with the outcome of pegylated interferon and ribavirin therapy in patients with chronic hepatitis C
Hepatol Res,41:584-93 2011
Author:Yoneda S, Umemura T, Joshita S, Ichijo T, Matsumoto A, Yoshizawa K, Katsuyama Y, Ota M, Tanaka E.


Polymorphism in the KCNA3 gene is associated with susceptibility to autoimmune pancreatitis in the Japanese population.
Dis Markers,31:223-9 2011
Author:Ota M, Ito T, Umemura T, Katsuyama Y, Yoshizawa K, Hamano H, Kawa S. 


Early detection of interstitial pneumonia by monitoring KL-6 in a chronic hepatitis C patient undergoing pegylated interferon and ribavirin therapy.
Hepatol Res,41(9):904-9 2011
Author:Ichikawa-Yamada Y, Joshita S, Tsukahara Y, Kimura T, Morita S, Kamijo A, Umemura T, Ichijo T, Matsumoto A, Yoshizawa K, Tanaka, E.


Clinical significance of immunoglobulin G4-associated autoimmune hepatitis
JOURNAL OF GASTROENTEROLOGY,46(S1):48-55 2011
Author:Umemura T, Zen Y, Hamano H, Joshita S, Ichijo T, Yoshizawa K, Kiyosawa K, Ota M, Kawa S, Nakanuma Y, Tanaka E.


Association of serum cytokine levels with treatment response to pegylated interferon and ribavirin therapy in genotype 1 chronic hepatitis C patients.
The Journal of Infectious Diseases,203:1087-95 2011
Author:Yoneda S, Umemura T, Katsuyama Y, Kamijo A, Joshita S, Komatsu M, Ichijo T, Matsumoto A, Yoshizawa K, Ota M, Tanaka E.


A case of pyogenic liver abscess infected with Fusobacterium necrophorum depicted by microscopy and confirmed by tissue culture
Intern Med,50(17):1815-9 2011
Author:Nozawa Y, Joshita S, Fukushima M, Sugiyama Y, Ichikawa Y, Kimura T, Morita S, Kamijo A, Umemura T, Ichijo T, Matsumoto A, Yoshizawa K, Tanaka E.


免疫抑制・化学療法中に発生するde novo B型肝炎 (特集 B型肝炎ウイルス再活性化の問題点と対策)
消化器内科,51(4):386-390 2010(Oct.)
Author:梅村 武司


Serum Fragmented Cytokeratin 18 Levels Reflect the Histologic Activity Score of Nonalcoholic Fatty Liver Disease More Accurately Than Serum Alanine Aminotransferase Levels
JOURNAL OF CLINICAL GASTROENTEROLOGY,44(6):440-447 2010(Jun.)
Author:Tsutsui, Masaru; Tanaka, Naoki; Kawakubo, Masatomo; Sheena, Yo; Horiuchi, Akira; Komatsu, Michiharu; Nagaya, Tadanobu; Joshita, Satoru; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Tanaka, Eiji; Sano, Kenji


A Novel Heterophilic Antibody Interaction Involves IgG4
SCANDINAVIAN JOURNAL OF IMMUNOLOGY,71(2):109-114 2010(Feb.)
Author:Ito, T.; Kitahara, K.; Umemura, T.; Ota, M.; Shimozuru, Y.; Kawa, S.; Bahram, S.


Nonalcoholic fatty liver disease in Japanese junior high school students: its prevalence and relationship to lifestyle habits
JOURNAL OF GASTROENTEROLOGY,45(6):666-672 2010(Jan.)
Author:Tsuruta, Goro; Tanaka, Naoki; Hongo, Minoru; Komatsu, Michiharu; Horiuchi, Akira; Hamamoto, Kaeko; Iguchi, Chieko; Nakayama, Yoshiko; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi;Tanaka, Eiji


DOWN-REGULATION OF SREBP-1C IS ASSOCIATED WITH THE DEVELOPMENT OF BURNED-OUT NASH
JOURNAL OF HEPATOLOGY,52(0):S373-S374 2010
Author:Nagaya, T.; Tanaka, N.; Komatsu, M.; Joshita, S.; Umemura, T.; Ichijo, T.; Matsumoto, A.; Yoshizawa, K.; Aoyama, T.; Tanaka, E.


CLINICAL AND VIROLOGICAL FEATURES OF PATIENTS WITH FULMINANT HEPATIC FAILUREDUE TO HEPATITIS B VIRUS REACTIVATION FROM HBSAG-NEGATIVE STATUS
JOURNAL OF HEPATOLOGY,52:S286-S286 2010
Author:Umemura, T.; Kiyosawa, K.; Tanaka, E.; Grp, Japan Novo Hepatitis B. Res


Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients.
JOURNAL OF HEPATOLOGY,53(3):537-541 2010
Author:Joshita S, Umemura T, Yoshizawa K, Katsuyama Y, Tanaka E, Nakamura M, Ishibashi H, Ota M, the Shinshu PBC Study Group.


Another cause of autoimmune hepatitis
HEPATOLOGY,52(1):389-340 2010
Author:Umemura T, Zen Y, Nakanuma Y, Kiyosawa K


A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients
HUMAN IMMUNOLOGY,71(5):520-524 2010
Author:Joshita S, Umemura T, Yoshizawa K, Katsuyama Y, Tanaka E, Ota M, the Shinshu PBC Study Group


A Patient with Advanced Hepatocellular Carcinoma Treated with Sorafenib Tosylate Showed Massive Tumor Lysis with Avoidance of Tumor Lysis syndrome
INTERNAL MEDICINE,49(11):991-994 2010
Author:Joshita, Satoru; Yoshizawa, Kaname; Sano, Kenji; Kobayashi, Satoshi; Sekiguchi, Tomohiro; Morita, Susumu; Kamijo, Atsushi; Komatsu, Michiharu; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Tanaka, Eiji


複数回治療後の再発性肝細胞癌の局所療法にソナゾイド^造影超音波が有用であった1例
肝臓,50(6):250-256 2009(May 25)
Author:米田 傑,城下 智,一條 哲也,上條 敦,小松 通治,梅村 武司,松本 晶博,吉澤 要,田中 榮司
Abstract:症例は68歳,女性.B型肝硬変にて治療中2004年に肝細胞癌(HCC)を初発し肝切除術を施行.その後再発に対して3回の肝動脈塞栓術(TAE)を施行した.2008年5月にCT上S4領域に径20 mmの再発病変を認めたが,肝動脈門脈シャントのためTAEができず,局所療法目的に当院紹介となった.CT, MRIではTAE後の結節と再発病変が混在していた.超音波(US)では,Bモードで多発する低エコー領域を認め質的診断は困難だったが,ソナゾイドTM造影USを追加したところ,一部に動脈相で濃染しKupffer相で低エコーを示すHCCに合致する病変を認め,局所療法が可能となった.3カ月後の造影USでは新たな再発を認めたが,やはり診断可能であり局所療法を行った.肝切除後の再発病変に複数回の再発治療を施行した症例であっても,造影USを施行することでBモードで評価困難な再発病変を診断でき,効果的な治療が可能であった.


A case of well-differentiated cholangiolocellular carcinoma visualized with contrast-enhanced ultrasonography using Sonazoid
HEPATOLOGY RESEARCH,39(2):207-212 2009(Feb.)
Author:Joshita, Satoru; Ichijo, Tetsuya; Suzuki, Fumitaka; Yokoyama, Takahide; Sugiyama, Yukiko; Fukushima, Mana; Kamijo, Atsushi; Komatsu, Michiharu; Umemura, Takeji; Yoshizawa, Kaname; Miyagawa, Shinichi; Tanaka, Eiji


Epidemiology of hepatocellular carcinoma in Japan
JOURNAL OF GASTROENTEROLOGY,44:102-107 2009
Author:Umemura, T; Ichijo, T; Yoshizawa, K; Tanaka, E; Kiyosawa, K


Association analysis of Toll-like receptor 4 polymorphisms with autoimmune pancreatitis
HUMAN IMMUNOLOGY,70:742-746 2009
Author:Umemura T, Katsuyama Y, Hamano H, Kitahara K, Takayama M, Arakura N, Kawa S, Tanaka E, Ota M.


A Novel Immunoglobulin-Immunoglobulin Interaction in Autoimmunity
PLOS ONE,3(2):- 2008(Feb.)
Author:Kawa, Shigeyuki; Kitahara, Kei; Hamano, Hideaki; Ozaki, Yayoi; Arakura, Norikazu; Yoshizawa, Kaname; Umemura, Takeji; Ota, Masao; Mizoguchi,Sadaaki; Shimozuru, Yasunori; Bahram, Seiamak


Mortality secondary to fulminant hepatic failure in patients with prior resolution of hepatitis B virus infection in Japan
CLINICAL INFECTIOUS DISEASES,47(5):E52-E56 2008
Author:Umemura, T; Tanaka, E; Kiyosawa, K; Kumada, H


Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese
HEPATOLOGY RESEARCH,38:689-695 2008
Author:Umemura T, Ota M, Yoshizawa K, Katsuyama Y, Ichijo T, Tanaka E, Kiyosawa K


Association of Autoimmune Pancreatitis With Cytotoxic T-lymphocyte Antigen 4 Gene Polymorphisms in Japanese Patients
AMERICAN JOURNAL OF GASTROENTEROLOGY,103(3):588-594 2008
Author:Umemura, T; Ota, M; Hamano, H; Katsuyama, Y; Muraki, T; Arakura, N; Kawa, S; Kiyosawa, K


腹壁への浸潤が疑われ, 画像検査が診断の契機となった肝放線菌症の1例
肝臓 = ACTA HEPATOLOGICA JAPONICA,48(11):553-558 2007(Nov. 25)
Author:武藤 英知,一條 哲也,小林 倫子,田中 直樹,梅村 武司,小松 通治,松本 晶博,吉澤 要,田中 榮司,上田 和彦,角谷 眞澄,清澤 研道
Abstract:症例は64歳,男性.胃全摘術,膵頭十二指腸切除術,糖尿病の既往がある.2004年3月に右季肋部痛を自覚.5月には同部位に腫瘤を触知したため近医を受診.低栄養状態が存在し,腹部CT検査にて肝S4に造影効果のある腫瘤を認めたため,肝悪性腫瘍が疑われ紹介された.しかし,腫瘤内部に門脈域を認めること,造影効果のない小さな液状成分が観察されることおよび体壁への直接浸潤がみられることから,膿瘍特に放線菌症の可能性が高いと判断し経皮的肝生検を施行した.組織学的に放線菌の菌塊を認めたため原発性肝放線菌症と確定診断した.ベンジルペニシリンベンザチン水和物(バイシリンG)120万単位/日の内服治療を開始,2カ月後には膿瘍ならびに体壁へ連続していた結節は縮小し,1年後には消失した.原発性肝放線菌症はまれな疾患であるが,画像所見で腹壁など周囲臓器への浸潤を認める肝膿瘍を見た時には,念頭に置くべきことを示唆する一例である.


Lack of association between FCRL3 and Fc gamma RII polymorphisms in Japanese type 1 autoimmune hepatitis
CLINICAL IMMUNOLOGY,122(3):338-342 2007
Author:Umemura, T; Ota, M; Yoshizawa, K; Katsuyama, Y; Ichijo, T; Tanaka, E; Kawa, S; Kiyosawa, K


Insulin resistance and hepatitis C virus: a case-control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serum aminotransferase
LIVER INTERNATIONAL,28(8):1104-1111 2007
Author:Tanaka, N; Nagaya, T; Komatsu, M; Horiuchi, A; Tsuruta, G; Shirakawa, H; Umemura, T; Ichijo, T; Matsumoto, A; Yoshizawa, K; Aoyama, T; Kiyosawa, K; Tanaka, E


ImmunoglobulinG4-hepatopathy: Association of IgG4-bearing plasma cells in liver with autoimmune pancreatitis
HEPATOLOGY,46:463-471 2007
Author:Umemura T, Zen Y, Hamano H, Kawa S, Nakanuma Y, Kiyosawa K.


IgG4-related sclerosing cholangitis should be included as an exclusion criterion for the diagnosis of primary sclerosing cholangitis
AMERICAN JOURNAL OF GASTROENTEROLOGY,102(3):691-692 2007
Author:Hamano, H; Umemura, T; Uehara, T; Kawa, S; Kiyosawa, K


IgG4 associated autoimmune hepatitis: a differential diagnosis for classical autoimmune hepatitis
GUT,56(10):1471-1472 2007
Author:Umemura, T; Zen, Y; Hamano, H; Ichijo, T; Kawa, S; Nakanuma, Y; Kiyosawa, K


Epidemiology of hepatocellular carcinoma in Japan
HEPATOLOGY RESEARCH,37(S2):S95-S100 2007
Author:Umemura, T; Kiyosawa, K


Anti-Helicobacter pylori seropositivity: influence on severity and treatment response in patients with chronic hepatitis C
JOURNAL OF VIRAL HEPATITIS,14(1):48-54 2007
Author:Umemura, T; Muto, H; Tanaka, E; Matsumoto, A; Ichijo, T; Yoshizawa, K; Akamatsu, T; Kiyosawa, K


Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population
LIVER INTERNATIONAL,26(8):956-963 2006
Author:Tanaka, N; Tanaka, E; Sheena, Y; Komatsu, M; Okiyama, W; Misawa, N; Muto, H; Umemura, T; Ichijo, T; Matsumoto, A; Yoshizawa, K; Horiuchi, A; Kiyosawa, K


Severe hepatic injury caused by orlistat
AMERICAN JOURNAL OF MEDICINE,119(8):E7-E7 2006
Author:Umemura, T; Ichijo, T; Matsumoto, A; Kiyosawa, K


Quantitative analysis of anti-hepatitis C virus anti body-secreting B cells in patients with chronic hepatitis C
HEPATOLOGY,43(1):91-99 2006
Author:Umemura, T; Wang, RYH; Schechterly, C; Shih, JWK; Kiyosawa, K; Alter, HJ


Patients with and without loss of hepatitis B virus DNA after hepatitis B e antigen seroconversion have different virological characteristics
JOURNAL OF MEDICAL VIROLOGY,78(1):68-73 2006
Author:Misawa, N; Matsumoto,A; Tanaka, E; Rokuhara, A; Yoshizawa, K; Umemura,T; Maki, N; Kimura, T; Kiyosawa, K


HepatitisB virus RNA is measurable in serum and canbe a new marker for monitoring lamivudine therapy
JOURNAL OF GASTROENTEROLOGY,41(8):785-790 2006
Author:Rokuhara, A; Matsumoto, A; Tanaka, E; Umemura, T; Yoshizawa, K; Kimura, T; Maki, N; Kiyosawa, K


Genetic association of Fc receptor-like 3 polymorphisms with autoimmune pancreatitis in Japanese patients
GUT,55(9):1367-1368 2006
Author:Umemura, T; Ota, M; Hamano, H; Katsuyama, Y; Kiyosawa, K; Kawa, S


Fulminant hepatitis after allogenic bone marrow transplantation caused by reactivation of hepatitis B virus with gene mutations in the core promotor region
EUROPEAN JOURNAL OF HAEMATOLOGY,77(3):255-258 2006
Author:Kitano, K; Kobayashi, H; Hanamura, M; Furuta, K; Ueno, M; Rokuhara, A; Tanaka, E; Umemura, T; Kiyosawa, K


A genome-wide DNA microsatellite association study of autoimmune hepatitis type 1 in Japan
HEPATOLOGY,44(4):228A-228A 2006
Author:Yoshizawa, K; Yokosawa, S; Ota, M; Katsuyama, Y; Ichijo, T; Umemura, T; Matsumoto, A; Tanaka, E; Kiyosawa, K


Age-specific antibody to hepatitis E virus has remained constant during the past 20 years in Japan
JOURNAL OF VIRAL HEPATITIS,12(4):439-442 2005
Author:Tanaka, E;Matsumoto, A; Takeda, N; Li, TC; Umemura,T; Yoshizawa, K; Miyakawa, Y; Miyamura, T; Kiyosawa, K


SEN virus infection and its relationship to transfusion-associated hepatitis
HEPATOLOGY,33:1303-1311 2001
Author:Umemura T, Yeo AET, Sottini A, Moratto A, Tanaka Y, Wang RYH, Shih JWK, Donahue P, Primi D, Alter HJ.


C型肝炎多発地域におけるTTV感染の疫学的検討
日本臨床,57:1397-1401 1999
Author:梅村武司


胆嚢原発と考えられた悪性線維性組織球腫の1例 : 本邦報告例の検討
日本消化器病學會雜誌 = The Japanese journal of gastro-enterology,95(2):161-166 1998(Feb. 05)
Author:折井 幸司,梅村 武司,松沢 正浩,吉江 崇宏,田村 泰夫,山村 伸吉,飯島 義浩,長田 敦夫,代田 廣志,中村 智次


脾動脈塞栓術後脾摘を施行したHairy cell leukemiaの1例
信州医学雑誌,45(1):27-34 1997(Feb. 10)
Author:梅村 武司,森下 博史,松沢 正浩,折井 幸司,高山 伸,吉江 崇宏,田村 泰夫,飯島 義浩,長田 敦夫,大畑 武夫,門馬 正志,中村 智次,林 正孝


十二指腸水平部憩室からの出血に純エタノール局注療法が有効であった1例
Endosc Forum digest dis,11:237-241 1995
Author:梅村武司