The mechanisms involved in the resistance of estrogen receptor-positive breast cancer cells to palbociclib are multiple and change over time JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,147(11):3211-3224 2021(Nov.) Author:Ono, Mayu; Oba, Takaaki; Shibata, Tomohiro; Ito, Ken-Ichi; Keywords:Breast cancer; Cyclin-dependent kinase inhibitor; Drug resistance; Palbociclib; Retinoblastoma gene;
HDAC6 inhibition enhances the anti-tumor effect of eribulin through tubulin acetylation in triple-negative breast cancer cells BREAST CANCER RESEARCH AND TREATMENT,186(1):37-51 2021(Feb.) Author:Oba, Takaaki; Ono, Mayu; Matoba, Hisanori; Uehara, Takeshi; Hasegawa, Yoshie; Ito, Ken-ichi; Keywords:Eribulin; HDAC inhibitor; HDAC6; Triple-negative breast cancer; Tubulin acetylation;
Prognostic Nutritional Index Is Superior to Neutrophil-to-lymphocyte Ratio as a Prognostic Marker in Metastatic Breast Cancer Patients Treated With Eribulin ANTICANCER RESEARCH,41(1):445-452 2021(Jan.) Author:Oba, Takaaki; Maeno, Kazuma; Ono, Mayu; Ito, Tokiko; Kanai, Toshiharu; Ito, Ken-ichi; Keywords:Prognostic nutritional index; neutrophil-to-lymphocyte ratio; progression-free survival; metastatic breast cancer; eribulin;
Concomitant use of F-18-FDG PET-CT SUVmax is useful in the assessment of Ki67 labeling index in core-needle biopsy specimens of breast cancer GLAND SURGERY,10(1):1-9 2021(Jan.) Author:Nakajima, Hiroki; Maeno, Kazuma; Ito, Tokiko; Kanai, Toshiharu; Oba, Takaaki; Ono, Mayu; Takayama, Fumiyoshi; Uehara, Tsuyoshi; Ito, Ken-ichi; Keywords:Breast cancer; Ki67 labeling index; core needle biopsy; SUVmax;
Tamoxifen resistance alters sensitivity to 5-fluorouracil in a subset of estrogen receptor-positive breast cancer PLOS ONE,16(6):e0252822 2021 Author:Watanabe, Takayuki; Oba, Takaaki; Tanimoto, Keiji; Shibata, Tomohiro; Kamijo, Shinobu; Ito, Ken-ichi;
Bone morphogenetic protein-7 expression reflects the high proliferative ability and aggressiveness of thymic epithelial tumors JOURNAL OF THORACIC DISEASE,12(3):448-456 2020(Mar.) Author:Miura, Kentaro; Hamanaka, Kazutoshi; Uehara, Tsuyoshi; Momose, Masanobu; Kanai, Yukiko; Matsuoka, Shunichiro; Takeda, Tetsu; Agatsuma, Hiroyuki; Hyogotani, Akira; Ito, Ken-ichi; Keywords:Bone morphogenetic protein-7 (BMP-7); thymic epithelial tumors; thymoma; thymic cancer;
Comparative efficacy and safety of tyrosine kinase inhibitors for thyroid cancer: a systematic review and meta-analysis ENDOCRINE JOURNAL,67(12):1215-1226 2020 Author:Oba, Takaaki; Chino, Tatsunori; Soma, Ai; Shimizu, Tadafumi; Ono, Mayu; Ito, Tokiko; Kanai, Toshiharu; Maeno, Kazuma; Ito, Ken-ichi; Keywords:Thyroid cancer; Tyrosine kinase inhibitor; Adverse event; Meta-analysis;
Neoadjuvant chemotherapy-induced decrease of prognostic nutrition index predicts poor prognosis in patients with breast cancer BMC CANCER,20(1) 2020 Author:Oba, Takaaki; Maeno, Kazuma; Takekoshi, Daiya; Ono, Mayu; Ito, Tokiko; Kanai, Toshiharu; Ito, Ken-ichi; Keywords:Prognostic nutritional index; Disease-free survival; Neoadjuvant chemotherapy; Breast cancer;
癌微小環境研究up-date(第5回)癌微小環境に基づいた乳癌治療 Cancer board of the breast = キャンサーボードオブザブレスト,5(2):102-104 2019(Sep.) Author:伊藤 研一
FGF2-FGFR1 pathway activation together with thymidylate synthase upregulation is induced in pemetrexed-resistant lung cancer cells Oncotarget ,10:1171-1192 2019 Author:Miura K, Oba T, Hamanaka K, Ito K
Combination of two anti-tubulin agents, eribulin and paclitaxel, enhances anti-tumor effects on triple-negative breast cancer through mesenchymal-epithelial transition. Oncotarget,9(33):22986-23002 2018(May) Author:Oba T, Ito KI.
Increased Expression of Y-Box-Binding Protein-1 in Hind-Limb Muscles During Regeneration from Ischemic Injury in Mice TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE,244(1):53-62 2018(Jan.) Author:Fuke, Megumi; Narita, Makoto; Wada, Yuko; Seto, Tatsuichiro; Okada, Kenji; Nakayama, Jun; Izumi, Hiroto; Ito, Ken-ichi; Keywords:critical limb ischemia; ischemic injury; mouse model system; regeneration; YB-1;
Chylous leakage after axillary lymph node dissection in a patient with breast cancer BREAST JOURNAL,24(3):438-440 2018 Author:Oba, Takaaki; Ono, Mayu; Iesato, Asumi; Hanamura, Toru; Watanabe, Takayuki; Ito, Tokiko; Kanai, Toshiharu; Maeno, Kazuma; Ito, Ken-ichi; Keywords:axillary lymph node dissection; breast cancer; chylous leakage;
Analysis of surgical treatment of Masaoka stage III-IV thymic epithelial tumors. Gen Thorac Cardiovasc Surg,:in press 2018 Author:Hamanaka K, Koyama T, Matsuoka S, Takeda T, Miura K, Yamada K, Hyogotani A, Seto T, Okada K, Ito KI.
A Case of Adenomyoepithelioma of the Breast Showing Strong Uptake of (18) F-Fluorodeoxyglucose on a Positron Emission Tomography. Breast J,23(2):220-224 2017(Mar.) Author:Oba T, Maeno K, Ono M, Iesato A, Ito T, Kanai T, Mochizuki Y, Ito KI, Yoshizawa A, Takayama F.
Case of painless thyroiditis that developed during adjuvant chemotherapy for breast cancer. Int Cancer Conf J,6(4):184-187 2017 Author:Iesato A, Oba T, Ono K, Watanabe T, Ito T, Kanai T, Maeno K, Ito K.
Human 3 beta-hydroxysteroid dehydrogenase type 1 in human breast cancer: clinical significance and prognostic associations CANCER MEDICINE,5(7):1405-1415 2016(Jul.) Author:Hanamura, Toru; Ito, Tokiko; Kanai, Toshiharu; Maeno, Kazuma; Shimojo, Yasuyo; Uehara, Takeshi; Suzuki, Takashi; Hayashi, Shin-ichi; Ito, Ken-ichi; Keywords:3 beta-hydroxysteroid dehydrogenase type 1; breast cancer; clinical significance; prognosis; steroid metabolism;
Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review ONCOTARGETS AND THERAPY,9:1641-1646 2016 Author:Oba, Takaaki; Ono, Mayu; Iesato, Asumi; Hanamura, Toru; Watanabe, Takayuki; Ito, Tokiko; Kanai, Toshiharu; Maeno, Kazuma; Ito, Ken-ichi; Tateishi, Ayako; Yoshizawa, Akihiko; Takayama, Fumiyoshi; Keywords:breast cancer; estrogen receptor; endocrine therapy;
ABCB1 and ABCC11 confer resistance to eribulin in breast cancer cell lines ONCOTARGET,7(43):70011-70027 2016 Author:Oba, Takaaki; Izumi, Hiroto; Ito, Ken-ichi; Keywords:eribulin; drug resistance; breast cancer; ABCB1; ABCC11;
Significance of sentinel lymph nodes with low gamma counts in breast cancer patients via radioisotopic sentinel lymph node biopsy Arch Surg Oncol,2:1 2016 Author:Maeno K, Ito T, Koyama H, Kanai T, Mochizuki Y, Ito K
Breast metastases of gastric signet-ring cell carcinoma: a report of two cases and review of the literature ONCOTARGETS AND THERAPY,8:91-97 2015 Author:Iesato, Asumi; Oba, Takaaki; Ono, Mayu; Hanamura, Toru; Watanabe, Takayuki; Ito, Tokiko; Kanai, Toshiharu; Maeno, Kazuma; Ishizaka, Katsuhiko; Kitabatake, Hiroyuki; Takeuchi, Daisuke; Suzuki, Akira; Nakayama, Jun; Ito, Ken-ichi; Keywords:gastric carcinoma; breast metastasis; signet-ring cell carcinoma; gastric cancer; breast cancer;
Coexpression of EpCAM, CD44 Variant Isoforms and Claudin-7 in Anaplastic Thyroid Carcinoma PLOS ONE,9(4):e94487 2014 Author:Okada, Toshihiro; Nakamura, Teruo; Watanabe, Takayuki; Onoda, Naoyoshi; Ashida, Atsuko; Okuyama, Ryuhei; Ito, Ken-ichi;
Rapid tumor necrosis and massive hemorrhage induced by bevacizumab and paclitaxel combination therapy in a case of advanced breast cancer ONCOTARGETS AND THERAPY,6:1393-1398 2013 Author:Ono, Mayu; Ito, Tokiko; Kanai, Toshiharu; Murayama, Koichi; Koyama, Hiroshi; Maeno, Kazuma; Mochizuki, Yasuhiro; Iesato, Asumi; Hanamura, Toru; Okada, Toshihiro; Watanabe, Takayuki; Ito, Ken-ichi; Keywords:bevacizumab; breast cancer; necrosis; hemorrhage; adverse event; paclitaxel;
Expression of Polypeptide N-Acetylgalactosaminyl Transferase-3 and Its Association with Clinicopathological Factors in Thyroid Carcinomas THYROID,23(12):1553-1560 2013 Author:Mochizuki, Yasuhiro; Ito, Ken-ichi; Izumi, Hiroto; Kohno, Kimitoshi; Amano, Jun;
Association of Nuclear YB-1 Localization With Lung Resistance-related Protein and Epidermal Growth Factor Receptor Expression in Lung Cancer CLINICAL LUNG CANCER,13(5):375-384 2012(Sep.) Author:Hyogotani, Akira; Ito, Ken-ichi; Yoshida, Kazuo; Izumi, Hiroto; Kohno, Kimitoshi; Amano, Jun; Keywords:Epidermal growth factor receptor; Lung cancer; Lung resistance-related protein; prognosis; Y-box binding protein 1;
Alteration of Y-box binding protein-1 expression modifies the response to endocrine therapy in estrogen receptor-positive breast cancer BREAST CANCER RESEARCH AND TREATMENT,133(1):145-159 2012(May) Author:Ito, Tokiko; Kamijo, Shinobu; Izumi, Hiroto; Kohno, Kimitoshi; Amano, Jun; Ito, Ken-ichi; Keywords:YB-1; Breast cancer; Endocrine therapy; Crosstalk;
Multimodality therapeutic outcomes In anaplastic thyroid carcinoma: Improved survival in subgroups of patients with localized primary tumors HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK,34(2):230-237 2012(Feb.) Author:Ito, Ken-ichi; Hanamura, Toru; Murayama, Koichi; Okada, Toshihiro; Watanabe, Takayuki; Harada, Michihiko; Ito, Tokiko; Koyama, Hiroshi; Kanai, Toshiharu; Maeno, Kazuma; Mochizuki, Yasuhiro; Amano, Jun; Keywords:anaplastic thyroid carcinoma; surgical treatment; chemotherapy; radiation; multimodality approach;
Hepatocyte growth factor prevents pulmonary ischernia-reperfusion injury in mice JOURNAL OF HEART AND LUNG TRANSPLANTATION,26(9):935-943 2007(Sep.) Author:Makiuchi, Akiko; Yamaura, Kazuhiro; Mizuno, Shinya; Matsumoto, Kunio; Nakamura, Toshikazu; Amano, Jun; Ito, Ken-ichi;
Increased nuclear localization of transcription factor Y-box binding protein 1 accompanied by up-regulation of P-glycoprotein in breast cancer pretreated with paclitaxel CLINICAL CANCER RESEARCH,11(24):8837-8844 2005 Author:Fujita T, Ito K, Izumi H, Kimura M, Sano M, Nakagomi H, Maeno K, Hama Y, Shingu K, Tsuchiya S, Kohno K, Fujimori M
Stimulation of P19CL6 with multiple reagents induces pulsating particles in vivo CURRENT MEDICAL RESEARCH AND OPINION,21(5):795-803 2005 Author:Ohtsu Y, Johkura K, Ito K, Akashima T, Asanuma K, Ogiwara N, Oka T, Komuro I, Sasaki K, Amano J
Suppression of acute and chronic rejection by hepatocyte growth factor in a murine model of cardiac transplantation - Induction of tolerance and prevention of cardiac allograft vasculopathy CIRCULATION,110(12):1650-1657 2004 Author:Yamaura, K; Ito, K; Tsukioka, K; Wada, Y; Makiuchi, A; Sakaguchi, M; Akashima, T; Fujimori, M; Sawa, Y; Morishita, R; Matsumoto, K; Nakamura, T; Suzuki, J; Amano, J; Isobe, M
Mutation of the class I beta-tubulin gene does not predict response to paclitaxel for breast cancer CANCER LETTERS,198(1):89-97 2003 Author:Maeno K, Ito K, Hama Y, Shingu K, Kimura M, Sano M, Nakagomi H, Tsuchiya S, Fujimori M
Mutation of proline residues in the NH2-terminal region of the multidrug resistance protein, MRP1(ABCC1): effects on protein expression, membrane localization, and transport function. Biochim Biophys Acta-Biomember1615,:103-114 2003 Author:Ito K, Weigl LE, Deeley RG, Cole SPC.
Mutation of Trp1254 in the multispecific organic anion transporter, MRP2 (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity J. Biol. Chem,276:38108-38114 2001 Author:Ito K, Oleschuk CJ, Westlake C, Vasa MZ, Deeley RG, Cole SPC
Mutation of a Single Conserved Tryptophan in Multidrug Resistance Protein 1 (MRP1/ABCC1) Results in Loss of Drug Resistance and Selective Loss of Organic Anion Transport J. Biol. Chem,276:15616-15624 2001 Author:K. Ito/ S. Cole
Clinical significance of the increased multidrug resistance-associated protein (MRP) gene expression in patients with primary breast cancer Oncol Res,10:99-109 1998 Author:K. Ito/ M. Fujimori/ J. Amano
Expression of tissue-type plasminogen activator and its inhibitor couples with development of capillary network by human microvascular endothelial cells on Matrigel J. Cell. Physiol,162:213-024 1995 Author:Ito K, Ryuto M, Ushiro S, Ono M, Sugenoya A, Kuraoka A, Shibata Y, Kuwano M
anti-angiogenic activity of arachidonic acid metabolism inhibitors in angiogenesis model systems involving human microvasucular endothelial cells and neovascularization in mice. Int J Cancer,55(4):660-666 1993 Author:Ito k, Abe T, Tomita M, Morimoto A, Kohno K, Mori T, Ono M, Sugenoya A, Nishihira T, Kuwano M.
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