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山条 秀樹  サンジョウ ヒデキ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 免疫制御学FAX番号
職名准教授メールアドレスhsanjo@shinshu-u.ac.jp
住所〒390-8621 松本市旭3-1-1ホームページURL

プロフィール

研究分野
免疫学
分子生物学
キーワード:免疫関連受容体の細胞内シグナル伝達 , Mononuclear phagocytes , Neutrophil , 炎症性細胞死 , 細胞分化・生存 , 炎症反応の開始及び収束 , 獲得免疫応答
現在の研究課題
シグナル伝達分子群による免疫恒常性維持の制御機構について
キーワード:シグナル伝達
所属学会
所属学会
日本免疫学会
日本分子生物学会
日本インターフェロン・サイトカイン学会
マクロファージ分子細胞生物学研究会
学歴
出身大学院
2003 , 大阪大学 , 医学系研究科 , 生体制御医学
1997 , 熊本大学 , 理学系研究科 , 生物科学

出身学校・専攻等(大学院を除く)
1995 , 鳥取大学 , 医学部 , 生命科学科

取得学位
医学博士 , 大阪大学
理学修士 , 熊本大学
研究職歴等
研究職歴
2016- , 信州大学・准教授
2010-2016 , 信州大学・助教
2003-2006 , 理化学研究所・研究員
1997-1999 , 科学技術振興事業団・技術員

留学歴
2006-2010 , La Jolla Institute for Allergy&Immunology, Sanford-Burnham Medical Institute

研究活動業績

研究業績(著書・
発表論文等)
論文
Adrenomedullin Ameliorates Pulmonary Fibrosis by Regulating TGF-beta-Smads Signaling and Myofibroblast Differentiation
ENDOCRINOLOGY,162(8) 2021(Aug.)
Author:Wei, Yangxuan; Tanaka, Megumu; Sakurai, Takayuki; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Cui, Nanqi; Kakihara, Shinji; Zhao, Yunlu; Aruga, Kohsuke; Sanjo, Hideki; Shindo, Takayuki;
Keywords:adrenomedullin; RAMP2; pulmonary fibrosis; Myofibroblast; TGF-beta; Smad; microRNA-21;


Extracellular mRNA transported to the nucleus exerts translation-independent function
NATURE COMMUNICATIONS,12(1) 2021
Author:Tomita, Takeshi; Kato, Masayoshi; Mishima, Taishi; Matsunaga, Yuta; Sanjo, Hideki; Ito, Ken-ichi; Minagawa, Kentaro; Matsui, Toshimitsu; Oikawa, Hiroyuki; Takahashi, Satoshi; Takao, Toshifumi; Iwai, Noriki; Mino, Takashi; Takeuchi, Osamu; Maru, Yoshiro; Hiratsuka, Sachie;


Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death.
J Immunol 2019
Author:Sanjo H, Nakayama J, Yoshizawa T, Fehling HJ, Akira S, Taki S.


Generation of a common innate lymphoid cell progenitor requires interferon regulatory factor 2.
Int Immunol. 2019
Author:Okubo Y, Tokumaru S, Yamamoto Y, Miyagawa SI, Sanjo H, Taki S.


Water intake increases mesenteric lymph flow and the total flux of albumin, long-chain fatty acids, and IL-22 in rats: new concept of absorption in jejunum.
Am J Physiol Gastrointest Liver Physiol. 2019
Author:Nagashio S, Ajima K, Maejima D, Sanjo H, Kajihara R, Hayashi M, Watanabe-Asaka T, Kaidoh M, Yokoyama Y, Taki S, Kawai Y, Ohhashi T.


Staphylococcal superantigen-like 12 activates murine bone marrow derived mast cells.
Biochem Biophys Res Commun. 2019
Author:Kobayashi M, Kitano T, Nishiyama S, Sanjo H, Onozaki K, Taki S, Itoh S, Hida S.


Loss of TAK1 leads to TLR-driven macrophage cell death and inflammation that occur by a TNF-independent mechanism
CYTOKINE,100:78-79 2017(Dec.)
Author:Sanjo, Hideki; Taki, Shinsuke;


Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCRalphabeta+ Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis.
PLoS One 2015
Author:Sanjo H, Tokumaru S, Akira S, Taki S.


Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-kappaB activation.
Science 2014
Author:Shinohara H, Behar M, Inoue K, Hiroshima M, Yasuda T, Nagashima T, Kimura S, Sanjo H, Maeda S, Yumoto N, Ki S, Akira S, Sako Y, Hoffmann A, Kurosaki T, Okada-Hatakeyama M.


Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs.
J Immunol. 2013
Author:Ori D, Kato H, Sanjo H, Tartey S, Mino T, Akira S, Takeuchi O.


Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors.
J Immunol. 2012
Author:Notake T, Horisawa S, Sanjo H, Miyagawa S, Hida S, Taki S.


Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor.
J Biol Chem 2010
Author:Sanjo H, Zajonc DM, Braden R, Norris PS, Ware CF.


Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability.
J Immunol. 2010
Author:Cheung TC, Coppieters K, Sanjo H, Oborne LM, Norris PS, Coddington A, Granger SW, Elewaut D, Ware CF.


Unconventional ligand activation of herpesvirus entry mediator signals cell survival.
Proc Natl Acad Sci U S A. 2009
Author:Cheung TC, Steinberg MW, Oborne LM, Macauley MG, Fukuyama S, Sanjo H, D'Souza C, Norris PS, Pfeffer K, Murphy KM, Kronenberg M, Spear PG, Ware CF.


T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment.
J Immunol. 2009
Author:Cheung TC, Oborne LM, Steinberg MW, Macauley MG, Fukuyama S, Sanjo H, D'Souza C, Norris PS, Pfeffer K, Murphy KM, Kronenberg M, Spear PG, Ware CF.


Regulation of immunity through the LT beta receptor and HVEM-BTLA circuit
CYTOKINE,43(3):236-236 2008(Sep.)
Author:Ware, Carl F.; Cheung, Tim; DeTrez, Carl; Schneider, Kirsten; Sedy, John; Jacquin, Claire; Fukuyama, Satoshi; Sanjo, Hideki; Greenberg, Brian;


Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion.
Immunity 2008
Author:Yasuda T, Sanjo H, Pages G, Kawano Y, Karasuyama H, Pouyssegur J, Ogata M, Kurosaki T.


Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin G.
Mol Cell Biol. 2007
Author:Sanjo H, Hikida M, Aiba Y, Mori Y, Hatano N, Ogata M, Kurosaki T.


TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells
INTERNATIONAL IMMUNOLOGY,18(10):1405-1411 2006(Oct.)
Author:Sato, Shintaro; Sanjo, Hideki; Tsujimura, Tohru; Ninomiya-Tsuji, Jun; Yamamoto, Masahiro; Kawai, Taro; Takeuchi, Osamu; Akira, Shizuo;


Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling
NATURE IMMUNOLOGY,7(9):962-970 2006(Sep.)
Author:Yamamoto, Masahiro; Okamoto, Toru; Takeda, Kiyoshi; Sato, Shintaro; Sanjo, Hideki; Uematsu, Satoshi; Saitoh, Tatsuya; Yamamoto, Naoki; Sakurai, Hiroaki; Ishii, Ken J.; Yamaoka, Shoji; Kawai, Taro; Matsuura, Yoshiharu; Takeuchi, Osamu; Akira, Shizuo;


TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis
JOURNAL OF BIOLOGICAL CHEMISTRY,281(28):19610-19617 2006
Author:Omori, Emily; Matsumoto, Kunihiro; Sanjo, Hideki; Sato, Shintaro; Akira, Shizuo; Smart, Robert C.; Ninomiya-Tsuji, Jun;


Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway.
Cell 2006
Author:Zhu P, Baek SH, Bourk EM, Ohgi KA, Garcia-Bassets I, Sanjo H, Akira S, Kotol PF, Glass CK, Rosenfeld MG, Rose DW


TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.
J Biol Chem 2006
Author:Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J.


BANK negatively regulates Akt activation and subsequent B cell responses.
Immunity 2006
Author:Aiba Y, Yamazaki T, Okada T, Gotoh K, Sanjo H, Ogata M, Kurosaki T.


PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.
J Exp Med. 2005
Author:Shinohara H, Yasuda T, Aiba Y, Sanjo H, Hamadate M, Watarai H, Sakurai H, Kurosaki T.


Essential function for the kinase TAK1 in innate and adaptive immune responses.
Nat Immunol. 2005
Author:Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S.


TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway.
Genes Cells 2005
Author:Kishida S, Sanjo H, Akira S, Matsumoto K, Ninomiya-Tsuji J.


The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.
J Exp Med. 2004
Author:Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H, Kawai T, Hoshino K, Takeda K, Akira S.


Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
Science 2003
Author:Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S


TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling.
Mol Cell Biol 2003
Author:Sanjo H, Takeda K, Tsujimura T, Ninomiya-Tsuji J, Matsumoto K, Akira S.


Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
Nature 2002
Author:Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S.


Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Nat Immunol. 2002
Author:Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S.


A Toll-like receptor recognizes bacterial DNA.
Nature 2000
Author:Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S.


A novel member of an expanding toll-like receptor family.
Gene 1999
Author:Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S.


Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Immunity 1999
Author:Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S.


Limb and skin abnormalities in mice lacking IKKalpha.
Science 1999
Author:Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S.


A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages.
J Immunol 1999
Author:Matsumoto M, Tanaka T, Kaisho T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Akira S.


Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains.
Gene 1999
Author:Kawai T, Sanjo H, Akira S.


Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.
J Immunol. 1999
Author:Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S.


DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis.
J Biol Chem. 1998
Author:Sanjo H, Kawai T, Akira S.


The gene structure and promoter analysis of mouse lymphocyte signal transduction molecule alpha 4 that is related to the yeast TAP42 involved in a rapamycin-sensitive pathway
Gene 1998
Author:Maeda K, Inui S, Sanjo H, Sakaguchi N.


ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.
Mol Cell Biol. 1998
Author:Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S.


Ig receptor binding protein 1 (alpha4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A.
Blood 1998
Author:Inui S, Sanjo H, Maeda K, Yamamoto H, Miyamoto E, Sakaguchi N.

研究費
科学研究費補助金(研究代表者)
2021 - 2023 , TNFシグナル関連分子群に着目したマクロファージの運命決定制御機構の解明 , 基盤研究(C)(一般)
2016 - 2018 , TNFシグナル関連分子群に着目したマクロファージの発生分化制御機構の解明 , 基盤研究(C)
2011 - 2012 , 好塩基球のサイトカイン産生と2型免疫応答発動に関与するシグナル伝達経路の制御機構 , 若手研究(B)

受託事業
家族性地中海熱(FMF)インフラマソームシグナル伝達異常をゲノム創薬で解決する開発研究

教育活動実績

授業等
前期 , 人間疾病・治療学概論1
前期 , 分子生体防御学
後期 , 免疫学