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中澤 英之  ナカザワ ヒデユキ

教員組織学術研究院(医学系(附属病院))電話番号
教育組織医学部附属病院 内科(2)FAX番号
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研究分野
血液内科
学歴
取得学位
博士(医学) , 信州大学

研究活動業績

研究業績(著書・
発表論文等)
著書
セリアック病
日本臨床社 , 消化管症候群(第2版)下 , :515-517 2009
Author:石田文宏, 中澤英之


論文
Outcomes of second allogeneic haematopoietic stem cell transplantation in patients with relapse of myelodysplastic syndrome
BRITISH JOURNAL OF HAEMATOLOGY,186(1):86-90 2019(Jul.)
Author:Shimomura, Yoshimitsu; Hara, Masahiko; Tachibana, Takayoshi; Ohashi, Kazuteru; Sakura, Toru; Fukuda, Takahiro; Nakazawa, Hideyuki; Iwato, Koji; Kanda, Yoshinobu; Ikeda, Takashi; Eto, Tetsuya; Kanda, Junya; Ichinohe, Tatsuo; Atsuta, Yoshiko; Ishikawa, Takayuki; Ishiyama, Ken;


STAT3 mutations in natural killer cells are associated with cytopenia in patients with chronic lymphoproliferative disorder of natural killer cells
INTERNATIONAL JOURNAL OF HEMATOLOGY,109(5):563-571 2019(May)
Author:Kawakami, Toru; Sekiguchi, Nodoka; Kobayashi, Jun; Yamane, Taku; Nishina, Sayaka; Sakai, Hitoshi; Hirabayashi, Yukio; Nakazawa, Hideyuki; Ishida, Fumihiro;


Clinical Implications of t(11;14) in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,25(3):474-479 2019(Mar.)
Author:Takamatsu, Hiroyuki; Yamashita, Takeshi; Kurahashi, Shingo; Saitoh, Takayuki; Kondo, Tadakazu; Maeda, Takeshi; Nakazawa, Hideyuki; Murata, Makoto; Narita, Tomoko; Kuroda, Junya; Hashimoto, Hisako; Kawamura, Koji; Miyamoto, Toshihiro; Honda, Sumihisa; Ichinohe, Tatsuo; Atsuta, Yoshiko; Sunami, Kazutaka;


多発性骨髄腫の最近の話題
信州医学雑誌,67(1):71-74 2019
Author:中澤 英之


Successful Empiric Therapy for Postsplenectomy Sepsis with Campylobacter fetus in an Abattoir Worker with Follicular Lymphoma
Internal Medicine,:- 2019
Author:Nakazawa Hideyuki;Nishina Sayaka;Sakai Hitoshi;Ito Toshiro;Ishida Fumihiro;Kitano Kiyoshi
Abstract:

Asplenia may yield an increased risk of fulminant sepsis with various pathogens. Human infection with Campylobacter fetus is rare, but it often presents with non-gastrointestinal tract infection among immunocompromised individuals. A 55-year-old abattoir worker presented with a fever. He had had splenectomy for follicular lymphoma and rituximab maintenance therapy by four months before the presentation. Blood cultures yielded C. fetus, and the administration of meropenem dissolved the bacteremia. Further maintenance therapy was withheld, and no recurrence of infection has been observed for seven years. Asplenia, occupational exposure, and/or rituximab maintenance therapy might have been precipitating factors of this rare infection.


Keywords:Campylobacter fetus;sepsis;splenectomy;rituximab;follicular lymphoma;abattoir


Efficacy, pharmacokinetics, and safety of the biosimilar CT-P10 in comparison with rituximab in patients with previously untreated low-tumour-burden follicular lymphoma: a randomised, double-blind, parallel-group, phase 3 trial
LANCET HAEMATOLOGY,5(11):E543-E553 2018(Nov.)
Author:Ogura, Michinori; Sancho, Juan Manuel; Cho, Seok-Goo; Nakazawa, Hideyuki; Suzumiya, Junji; Tumyan, Gayane; Kim, Jin Seok; Lennard, Anne; Mariz, Jose; Ilyin, Nikolai; Jurczak, Wojciech; Martinez, Aurelio Lopez; Samoilova, Olga; Zhavrid, Edvard; Ruiz, Eduardo Yanez; Trneny, Marek; Popplewell, Leslie; Coiffier, Bertrand; Buske, Christian; Kim, Woo-Seog; Lee, Sang Joon; Lee, Sung Young; Bae, Yun Ju; Kwak, Larry W.;


Impact of hematopoietic stem cell transplantation in patients with relapsed or refractory mantle cell lymphoma (vol 97, pg 1445, 2018)
ANNALS OF HEMATOLOGY,97(10):2013-2014 2018(Oct.)
Author:Yamasaki, Satoshi; Chihara, Dai; Kim, Sung-Won; Izutsu, Koji; Iwato, Kouji; Fukuda, Takahiro; Uchida, Naoyuki; Amano, Itsuto; Nakazawa, Hideyuki; Kuroda, Junya; Hashimoto, Hisako; Ichinohe, Tatsuo; Kanda, Yoshinobu; Atsuta, Yoshiko; Suzumiya, Junji; Suzuki, Ritsuro;


Impact of HIV Infection on Transplant Outcomes after Autologous Peripheral Blood Stem Cell Transplantation: A Retrospective Study of Japanese Registry Data
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,24(8):1596-1601 2018(Aug.)
Author:Yoshinaga, Noriyoshi; Kanda, Junya; Aisa, Yoshinobu; Hagiwara, Shotaro; Mori, Takehiko; Fukuda, Takahiro; Ishida, Yoji; Hashimoto, Hisako; Iwato, Koji; Kanda, Yoshinobu; Kurokawa, Mineo; Nakazawa, Hideyuki; Ota, Shuichi; Uchida, Naoyuki; Ichinohe, Tatsuo; Atsuta, Yoshiko; Takaori-Kondo, Akifumi;


Breakthrough Candida guilliermondii (Meyerozyma guilliermondii) fungemia after cord blood transplantation for extranodal NK-cell lymphoma with azole prophylaxis
TRANSPLANT INFECTIOUS DISEASE,20(4):- 2018(Aug.)
Author:Nakazawa, Hideyuki; Nishina, Sayaka; Senoo, Yasushi; Sakai, Hitoshi; Ito, Toshiro; Kikuchi, Ken; Ishida, Fumihiro;


Bortezomib maintenance therapy in transplant-ineligible myeloma patients who plateaued after bortezomib-based induction therapy: a multicenter phase II clinical trial
INTERNATIONAL JOURNAL OF HEMATOLOGY,108(1):39-46 2018(Jul.)
Author:Isoda, Atsushi; Murayama, Kayoko; Ito, Shigeki; Kohara, Yoichi; Iino, Masaki; Miyazawa, Yuri; Matsumoto, Morio; Handa, Hiroshi; Imai, Yosuke; Ishiguro, Takuro; Izumita, Wataru; Kitano, Kiyoshi; Hirabayashi, Yukio; Nakazawa, Hideyuki; Ishida, Fumihiro; Mitsumori, Toru; Kirito, Keita; Chou, Takaaki; Murakami, Hirokazu; Kanshinetsu Multiple Myeloma Study;


A novel genetic and morphologic phenotype of ARID2-mediated myelodysplasia
LEUKEMIA,32(3):839-843 2018(Mar.)
Author:Sakai, H.; Hosono, N.; Nakazawa, H.; Przychodzen, B.; Polprasert, C.; Carraway, H. E.; Sekeres, M. A.; Radivoyevitch, T.; Yoshida, K.; Sanada, M.; Yoshizato, T.; Kataoka, K.; Nakagawa, M. M.; Ueno, H.; Nannya, Y.; Kon, A.; Shiozawa, Y.; Takeda, J.; Shiraishi, Y.; Chiba, K.; Miyano, S.; Singh, J.; Padgett, R. A.; Ogawa, S.; Maciejewski, J. P.; Makishima, H.;


剖検時中枢神経系にEBV関連リンパ増殖性疾患の併発を認めた末梢性T細胞リンパ腫の1例
信州医学雑誌,66(4):257-262 2018
Author:小松 登;北野 喜良;川上 史裕;磯部 玲;金子 直也;平林 幸生;伊藤 俊朗;中澤 英之;大谷 真紀;中澤 功
Abstract:A 74-year-old man visited a hospital with complaints of skin diseases, pancytopenia and splenomegaly one year and nine months earlier, when he was diagnosed with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), based on a skin biopsy. The chemotherapies, such as CHOP and GDP, yielded only stable disease. Ten months later he was hospitalized because of a seizure, and MRI revealed a space-occupying lesion in the right occipital lobe and a brain biopsy revealed invasion of PTCL-NOS into the central nervous system (CNS). Although he was treated with dexamethasone, fever, systemic lymphadenopathies, hepatosplenomegaly, seizures, left hemiparesis, visual field defects, prolonged disturbance of consciousness, and deterioration of the pancytopenia and pulmonary infiltrations ensued. The patient died on the 54th hospital day. An autopsy showed systemic infiltration of PTCL-NOS and pulmonary mucormycosis. In addition to the CNS lesion of PTCL-NOS, focal and condensed infiltrations of CD20-, MUM1- and EBER-positive cells were detected around Virchow-Robin spaces in the parietal and occipital lobes, leading to a diagnosis of EBV-related lymphoproliferative disorder (EBV-LPD). The present case suggests that primary CNS EBV-LPD might develop in the presence of an immunocompromised state caused by both PTCL-NOS and its treatments.
Keywords:末梢性T細胞性リンパ腫;EBウイルス関連リンパ増殖性疾患;ムコール症;免疫不全


ビタミンB6が著効したALAS2 R452H変異陽性X連鎖性鉄芽球性貧血
臨床血液,59(4):401-406 2018
Author:川上 徹;小松 通治;梅村 武司;山口 智美;古庄 知己;藤原 亨;張替 秀郎;石田 文宏;中澤 英之;川上 史裕;松澤 周治;須藤 裕里子;酒井 均;仁科 さやか;妹尾 紀子;妹尾 寧
Abstract:

易疲労感と手指関節痛を主訴に受診した45歳男性。18歳時にも鉄芽球性貧血を疑われた既往があるが通院が途絶えていた。受診時小球性貧血と血清フェリチンの著増があり,骨髄検査では環状鉄芽球の増加を認めた。肝生検ではヘモクロマトーシスと肝硬変の所見を認めた。遺伝子検査の結果,ALAS2遺伝子のR452H変異が認められ,X連鎖鉄芽球性貧血(XLSA)と診断した。葉酸,経口ビタミン(Vit)B12製剤の投与では貧血の改善はみられず,経口VitB6製剤を追加することで7 g/dl台だったHbは11 g/dl台まで上昇し,鉄過剰症に伴う臓器障害の改善を図るべく瀉血も可能となった。これまでの報告ではALAS2 R452H変異はVitB6に反応しにくいとされていた。本例のような反応良好例の蓄積によってXLSAの病態および治療法の解明が進むと考えられる。


Keywords:X-linked sideroblastic anemia;ALAS2 R452H;VitB6


Severe Infection of Pseudomonas aeruginosa during Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria
INTERNAL MEDICINE,57(1):127-130 2018
Author:Kawakami, Toru; Nakazawa, Hideyuki; Kurasawa, Yukifumi; Sakai, Hitoshi; Nishina, Sayaka; Senoo, Noriko; Senoo, Yasushi; Ishida, Fumihiro;


Frequent STAT3 Mutations in CD8(+) T Cells from Patients with Pure Red Cell Aplasia
BLOOD,132:- 2018
Author:Kawakami, Toru; Sekiguchi, Nodoka; Kobayashi, Jun; Imi, Tatsuya; Matsuda, Kazuyuki; Yamane, Taku; Nishina, Sayaka; Senoo, Yasushi; Sakai, Hitoshi; Ito, Toshiro; Koizumi, Tomonobu; Hirokawa, Makoto; Nakao, Shinji; Nakazawa, Hideyuki; Ishida, Fumihiro;


Comparison of Efficacy and Safety of Biosimilar CT-P10 to Rituximab in Patients with Previously Untreated Low Tumor Burden Follicular Lymphoma (LTBFL): A Randomized Phase III Study
BLOOD,132:- 2018
Author:Ogura, Michinori; Manuel Sancho, Juan; Cho, Seok-Goo; Nakazawa, Hideyuki; Suzumiya, Junji; Tumyan, Gayane; Kim, Jin Seok; Lennard, Anne; Mariz, Jose Mario; Ilyin, Nikolai; Jurczak, Wojciech; Lopez Martinez, Aurelio; Samoilova, Olga; Zhavrid, Edvard; Yanez Ruiz, Eduardo; Trneny, Marek; Popplewell, Leslie; Coiffier, Bertrand; Buske, Christian; Kim, Won Seog; Lee, SangJoon; Lee, Sungyoung; Bae, Yunju; Kwak, Larry W.;


Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target
NATURE COMMUNICATIONS,9:- 2018
Author:Dufva, Olli; Kankainen, Matti; Kelkka, Tiina; Sekiguchi, Nodoka; Awad, Shady Adnan; Eldfors, Samuli; Yadav, Bhagwan; Kuusanmaki, Heikki; Malani, Disha; Andersson, Emma I.; Pietarinen, Paavo; Saikko, Leena; Kovanen, Panu E.; Ojala, Teija; Lee, Dean A.; Loughran, Thomas P., Jr.; Nakazawa, Hideyuki; Suzumiya, Junji; Suzuki, Ritsuro; Ko, Young Hyeh; Kim, Won Seog; Chuang, Shih-Sung; Aittokallio, Tero; Chan, Wing C.; Ohshima, Koichi; Ishida, Fumihiro; Mustjoki, Satu;


A New Prognostic Index for Waldenstrom Macroglobulinemia Based on a Multicenter Retrospective Study of the Japanese Society of Myeloma
BLOOD,132:- 2018
Author:Saito, Akio; Isoda, Atsushi; Odajima, Takeshi; Itagaki, Mitsuhiro; Yamamoto, Go; Hagiwara, Shotaro; Ohno, Tatsuharu; Fujimoto, Ayumi; Sekiguchi, Naohiro; Sunami, Kazutaka; Yokohama, Akihiko; Kurokawa, Mineo; Tsukune, Yutaka; Nakazawa, Hideyuki; Takamatsu, Hiroyuki; Yagi, Hideo; Fuchida, Shin-Ichi; Ito, Shigeki; Harazaki, Yoriko; Watanabe, Reiko; Koike, Michiaki; Miyazaki, Kanji; Suzuki, Kazuhito; Tamura, Hideto; Kohara, Takae; Ozaki, Shuji; Nakamura, Nobuhiko; Nakamura, Yuichi; Wakayama, Toshio; Sugimori, Hiroki; Murakami, Hirokazu;


Oral cyclophosphamide was effective for Coombs-negative autoimmune hemolytic anemia in CD16+CD56-chronic lymphoproliferative disorder of NK-cells
INTERNATIONAL JOURNAL OF HEMATOLOGY,105(6):854-858 2017(Jun.)
Author:Sekiguchi, Nodoka; Nishina, Sayaka; Kawakami, Toru; Sakai, Hitoshi; Senoo, Noriko; Senoo, Yasushi; Ito, Toshiro; Saito, Hiroshi; Nakazawa, Hideyuki; Koizumi, Tomonobu; Ishida, Fumihiro;


A screening method with lymphocyte percentage and proportion of granular lymphocytes in the peripheral blood for large granular lymphocyte (LGL) leukemia
INTERNATIONAL JOURNAL OF HEMATOLOGY,105(1):87-91 2017(Jan.)
Author:Tanahashi, Takahiro; Sekiguchi, Nodoka; Matsuda, Kazuyuki; Matsumoto, Akihiro; Ito, Toshiro; Nakazawa, Hideyuki; Ishida, Fumihiro;


Recurrent STAT3 Mutations in the Lymphocytes of Pure Red Cell Aplasia without T-Cell Large Granular Lymphocytic Leukemia
BLOOD,130:- 2017
Author:Kawakami, Toru; Sekiguchi, Nodoka; Otsuka, Toshiya; Imi, Tatsuya; Nishina, Sayaka; Senoo, Noriko; Senoo, Yasushi; Sakai, Hitoshi; Ito, Toshiro; Koizumi, Tomonobu; Nakao, Shinji; Nakazawa, Hideyuki; Ishida, Fumihiro;


Cell size variations of large granular lymphocyte leukemia: Implication of a small cell subtype of granular lymphocyte leukemia with STAT3 mutations
LEUKEMIA RESEARCH,45:8-13 2016(Jun.)
Author:Tanahashi, Takahiro; Sekiguchi, Nodoka; Matsuda, Kazuyuki; Takezawa, Yuka; Ito, Toshiro; Kobayashi, Hikaru; Ichikawa, Naoaki; Nishina, Sayaka; Senoo, Noriko; Sakai, Hitoshi; Nakazawa, Hideyuki; Ishida, Fumihiro;


Early detection of Rhizopus DNA in the serum of a patient with rhino-orbital-cerebral mucormycosis following allogeneic hematopoietic stem cell transplantation
INTERNATIONAL JOURNAL OF HEMATOLOGY,103(3):354-355 2016(Mar.)
Author:Shigemura, Tomonari; Nishina, Sayaka; Nakazawa, Hideyuki; Matsuda, Kazuyuki; Yaguchi, Takashi; Nakazawa, Yozo;


Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma
INTERNAL MEDICINE,55(13):1807-1810 2016
Author:Kawakami, Toru; Hirabayashi, Yukio; Kawakami, Fumihiro; Isobe, Rei; Kaneko, Naoto; Mimura, Yuto; Ito, Toshiro; Furuta, Kiyoshi; Shimazaki, Mami; Nakazawa, Hideyuki; Kitano, Kiyoshi;


High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia
BLOOD,128(20):2465-2468 2016
Author:Andersson, Emma I.; Tanahashi, Takahiro; Sekiguchi, Nodoka; Gasparini, Vanessa Rebecca; Bortoluzzi, Sabrina; Kawakami, Toru; Matsuda, Kazuyuki; Mitsui, Takeki; Eldfors, Samuli; Bortoluzzi, Stefania; Coppe, Alessandro; Binatti, Andrea; Lagstrom, Sonja; Ellonen, Pekka; Fukushima, Noriyasu; Nishina, Sayaka; Senoo, Noriko; Sakai, Hitoshi; Nakazawa, Hideyuki; Kwong, Yok-Lam; Loughran, Thomas P.; Maciejewski, Jaroslaw P.; Mustjoki, Satu; Ishida, Fumihiro;


Hematopoietic Stem Cell Transplantation for Diffuse Large B-Cell Lymphoma Harboring a 8q24/MYC Rearrangement: A Retrospective Registry Study from the Japan Society for Hematopoietic Cell Transplantation
BLOOD,128(22):- 2016
Author:Takahashi, Tsutomu; Suzuki, Ritsuro; Izutsu, Koji; Nakazawa, Hideyuki; Suzuki, Sachiko; Kuroda, Junya; Kaida, Katsuji; Ohno, Hitoshi; Fukuda, Takahiro; Ichinohe, Tatsuo; Atsuta, Yoshiko; Suzumiya, Junji;


Exogenous Magnesium Chloride Reduces the Activated Partial Thromboplastin Times of Lupus Anticoagulant-Positive Patients
PLOS ONE,11(6):- 2016
Author:Tokutake, Takayoshi; Baba, Hisami; Shimada, Yuji; Takeda, Wataru; Sato, Keijiro; Hiroshima, Yuki; Kirihara, Takehiko; Shimizu, Ikuo; Nakazawa, Hideyuki; Kobayashi, Hikaru; Ishida, Fumihiro;


Tumor lysis syndrome in a chronic lymphocytic leukemia patient with pleural effusion after oral fludarabine and cyclophosphamide therapy
Int J Hematol,99(6):782-785 2014
Author:Nakazawa H, Nishina S, Mimura Y, Kawakami T, Senoo Y, Sakai K, Nakazawa K, Kitano K


Screening Tests Using Serum Tissue Transglutaminase IgA May Facilitate the Identification of Undiagnosed Celiac Disease among Japanese Population
Int J Med Sci,11(8):819-823 2014
Author:Nakazawa H, Makishima H, Ito T, Ota H, Momose K, Sekiguchi N, Yoshizawa K, Akamatsu T, Ishida F


Development of Primary Central Nervous System Lymphoma Associated with Human Immunodeficiency Virus and JC Virus Infection
J Clin Exp Hematop,54(3):211-217 2014
Author:Kawakami T, Sakai K, Mimura Y, Senoo Y, Hirabayashi Y, Nakazawa H, Koshihara H, Oguchi K, Takei Y, Ohara S, Watanabe N, Nakazawa K, Oyanagi K, Kitano K


Azacitidine Treatment Following Intensive Chemotherapy with Daunorubicin and Cytarabin for Acute Transformation in Myelodysplastic/Myeloproliferative Neoplasms
Shinshu Medical Journal,62(3):167-172 2014
Author:Kawakami T, Sakai K, Nishina S, Mimura Y, Miyahira T, Senoo Y, Nakazawa H, Kitano K


(特集 小腸疾患の臨床 最近の進歩)セリアック病
臨牀消化器内科,28(7):1001-1006 2013
Author:中澤 英之, 石田 文宏


Richter transformation in the brain from chronic lymphocytic leukemia
J Clin Exp Hematol,52(2):157-160 2013
Author:Ishida F, Nakazawa H, Takezawa Y, Matsuda K, Asano N, Sano K, Sakai H, Ito T


Large vessel vasculitis developed early after allogeneic bone marrow transplant for acute erythroid leukemia
Leuk Lymphoma,54(12):2748-2749 2013
Author:Kawakami T, Ito T, Sakai H, Sekiguchi N, Nakazawa H, Senoo N, Nishina S, Ishida F


Torsion analysis in the early detection of anthracycline-mediated cardiomyopathy
Eur Heart J Cardiovasc Imaging,13(1):95-103 2012
Author:Motoki H, Koyama J, Nakazawa H, Aizawa K, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Takahashi M, Ikeda U


Spliceosome-related gene mutations in myelodysplastic syndrome can be used as stable markers for monitoring minimal residual disease during follow-up
Leuk Res,36(11):1393-1397 2012
Author:Matsuda K, Ishida F, Ito T, Nakazawa H, Miura S, Taira C, Sueki A, Kobayashi Y, Honda T


Primary gastric diffuse large B-cell lymphoma with orbital involvement: diagnostic usefulness of 18F-fluorodeoxyglucose positron emission tomography
Intern Med,50(18):1953-1956 2011
Author:Iwaya Y, Takenaka K, Akamatsu T, Yamada Y, Haba S, Matsuda K, Nakazawa H, Muraki T, Kaneko Y, Ito T, Sano K, Arakura N, Tanaka E, Ishida F


Late relapse of extranodal natural killer/T cell lymphoma, nasal type, after more than ten years
Leuk Lymphoma,51(1):171-173 2010
Author:Ishida F, Nishina S, Asano N, Sasaki S, Sekiguchi N, Nakazawa H, Ito T, Shikama N


Cytomegalovirus-induced infectious mononucleosis-like syndrome in a rheumatoid arthritis patient treated with methotrexate and infliximab
Intern Med,19(10):937-940 2010
Author:Shimojima Y1, Ishii W, Matsuda M, Nakazawa H, Ikeda S


悪性リンパ腫に脾破裂を合併するも救命が出来た透析患者の一例
長野県透析研究会誌,31(1):84-86 2008(Sep.)
Author:仁科 さやか; 橋本 幸始; 高橋 京子; 山田 重徳; 塚田 渉; 南 聡; 上条 祐司; 樋口 誠; 中澤 英之; 牧島 秀樹; 伊藤 俊朗; 石田 文宏;


症例 卵巣腫瘍に対してのschizophyllan投与14年後のT細胞性急性リンパ性白血病症例に認めたβ-D-glucan高値
内科,102(2):413-416 2008(Aug.)
Author:関口 和; 牧島 秀樹; 中澤 英之;


骨髄移植後のキメリズム解析を不可能にした再発時付加染色体異常
臨床血液 = The Japanese Journal of Clinical Hematology,49(2):109-114 2008(Feb. 29)
Author:樋口 由美子; 伊藤 俊朗; 松田 和之; 樋口 司; 日高 惠以子; 今川 英里; 宇原 美帆; 中澤 英之; 石田 文宏; 山内 一由; 佐野 健司; 勝山 努;
Abstract:61歳男性。trisomy 8を伴う白血病(M6)に対し,異性間同種末梢血幹細胞移植を施行した。11番染色体短腕上のマイクロサテライト領域を用いたキメリズム解析(PCR-STR)及び,8番染色体FISH法解析にて経過を観察した。移植10か月後に芽球の増加と,FISH法解析でtrisomy 8を示す細胞の増加を認め再発と考えられたが,PCR-STR法では100%ドナータイプであり,再発所見を示さなかった。そこで骨髄標本を用いたXY FISH法解析を行ったところ,芽球はレシピエント由来であることが確認された。この直後の染色体分析において,初発時の異常核型に加えてPCR-STR法で用いたマイクロサテライト領域を含む染色体の部分欠失del (11)(p10)という新たな付加異常が,解析した異常細胞全てに認められ,このことがPCR-STR法で再発を検出できなかった原因であった。
Keywords:Hematopoietic stem cell transplantation; Chimerism; Fluorescence in situ hybridization; FISH; Short tandem repeats; STR;


診断に苦慮したCD4+/CD56+ hematodermic neoplasm (blastic NK cell lymphoma) の1例
Skin Cancer,23(3):410-415 2008
Author:木藤 健治; 鶴田 恭子; 生垣 英之; 塩原 順子; 木庭 幸子; 高沢 裕子; 村田 浩; 太田 桂子; 高田 実; 斎田 俊明; 中澤 英之; 伊藤 俊郎; 石田 文宏; 福島 万奈; 浅野 直子; 中村 栄男;
Abstract:63歳, 男性。初診の4ヵ月前, 腰部に硬結が出現し近医を受診して, 悪性リンパ腫を疑われ, 当科へ紹介された。組織学的には小型~中型の異型リンパ球のび漫性増殖がみられ, cCD3 (+) , CD4 (+) , CD20 (+) の所見よりperipheral T-cell lymphoma, unspecifiedと診断した。CHOP療法6クールにて完全寛解 (CR) となったが, 約11ヵ月後に体幹・四肢に再発してきた。組織学的に初診時に比べて単調な異型リンパ球の増殖であり, CD4 (+) , CD79a (-) , CD56 (+) , CD123 (+) , TdT (-) , MPO (-) , EBV-ISH (-) の所見よりCD4+/CD56+ hematodermic neoplasm (blastic NK cell lymphoma) と診断した。CHOP療法2クールとhyper CVAD療法を1クール施行後, 同種末梢血幹細胞移植を実施し, 約半年間CRを維持している。
Keywords:CD4+/CD56+ hematodermic neoplasm; Blastic NK-cell lymphoma; CD123; Plasmacytoid dendritic cell; Peripheral blood stem cell transplantation;


消化管follicular lymphomaの特徴臨床的立場から内視鏡を中心に
胃と腸,43(2):1059-1066 2008
Author:金子 靖典, 赤松 泰次, 北原 桂, 須澤 兼一, 松田 賢介, 中澤英之, 牧島 秀樹, 五十嵐 亨, 宮田 和信, 福島 万奈, 田中 榮司


卵巣腫瘍に対してのschizophyllan投与14年後のT細胞性急性リンパ性白血病症例に認めたβ-D-glucan高値
内科,102(2):413-416 2008
Author:関口 和, 牧島 秀樹, 中澤 英之, 伊藤 俊朗, 石田 文宏


セリアック病
胃と腸,43(4):651-655 2008
Author:中澤英之, 牧島秀樹, 石田文宏, 太田浩良, 赤松泰次


Promising approach for aggressive NK cell leukaemia with allogeneic haematopoietic cell transplantation
Eur J Haematol,81(2):107-111 2008
Author:Ito T, Makishima H, Nakazawa H, Kobayashi H, Shimodaira S, Nakazawa Y, Kitano K, Matsuda K, Hidaka E, Ishida F


Neutrophilic dermatoses with acute myeloid leukemia associated with an increase of serum colony-stimulating factor
J Am Acad Dermatol,59(2 Suppl 1):S10-S12 2008
Author:Uhara H, Saida T, Nakazawa H, Ito T


Additional chromosomal changes in impaired chimeric analysis of a patient with relapsed leukemia after bone marrow transplantation
Rinsho Ketsueki,49(2):109-114 2008
Author:Higuchi Y, Ito T, Matsuda K, Higuchi T, Hidaka E, Imagawa E, Uhara M, Nakazawa H, Ishida F, Yamauchi K, Sano K, Katsuyama T


Close resemblance between chemokine receptor expression profiles of lymphoproliferative disease of granular lymphocytes and their normal counterparts in association with elevated serum concentrations of IP-10 and MIG
Int J Hematol,86(2):174-179 2007
Author:Momose K, Makishima H, Ito T, Nakazawa H, Shimodaira S, Kiyosawa K, Ishida F


Chemokine system and tissue infiltration in aggressive NK-cell leukemia
Leuk Res,31(9):1237-1245 2007
Author:Makishima H, Ito T, Momose K, Nakazawa H, Shimodaira S, Kamijo Y, Nakazawa Y, Ichikawa N, Ueno M, Kobayashi H, Kitano K, Saito H, Kiyosawa K, Ishida F


Migrating osteoarthralgia: a rare initial manifestation of adult leukemia
Intern Med,45(3):175-176 2006
Author:Fukushima K, Matsuda M, Mitsuhashi S, Gono T, Kaneko K, Nakazawa H, Ito T, Ikeda S


Intestinal diffuse large B-cell lymphoma associated with celiac disease: A Japanese case
INTERNATIONAL JOURNAL OF HEMATOLOGY,83(1):63-65 2006
Author:Makishima, H; Ito, T; Kodama, R; Asano, N; Nakazawa, H; Hirabayashi, K;Nakamura, S; Ota, M; Akamatsu, T; Kiyosawa, K; Ishida, F


Adenovirus fulminant hepatic failure: disseminated adenovirus disease after unrelated allogeneic stem cell transplantation for acute lymphoblastic leukemia
Intern Med,45(16):975-980 2006
Author:Nakazawa H, Ito T, Makishima H, Misawa N, Okiyama W, Uehara T, Hidaka E, Kiyosawa K, Ishida F


Significance of chemokine receptor expression in aggressive NK cell leukemia
LEUKEMIA,19(7):1169-1174 2005
Author:Makishima, H; Ito, T; Asano, N; Nakazawa, H; Shimodaira, S; Kamijo, Y; Nakazawa, Y; Suzuki, T; Kobayashi, H; Kiyosawa, K; Ishida, F


Induction of polyploidization by jaspamide in HL-60 cells
ACTA HAEMATOLOGICA,104(2-3):65-71 2000
Author:Nakazawa, H; Kitano, K; Cioca, DP; Ishikawa, M; Ueno, M; Ishida, F; Kiyosawa, K


MISC
医療の倫理ジレンマ
2003
Author:Bernard Lo(著), 北野喜良(訳), 中澤英之(訳), 小宮良輔(訳)

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