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西井 良典  ニシイ ヨシノリ

教員組織学術研究院(繊維学系)電話番号
教育組織繊維学部 化学・材料学科 応用分子科学コースFAX番号
職名教授メールアドレス
住所ホームページURL

更新日:2022/12/14

プロフィール

兼担研究科・学部
大学院総合工学系研究科
研究分野
有機化学
シクロプロパン化学
有機合成化学
天然物有機化学
キーワード:有機合成化学 , 有機化学 , 天然物有機化学 , 生物活性化合物
現在の研究課題
新規高選択的有機不斉反応の開発と生物活性化合物および機能性物質の合成
キーワード:光学活性有機化合物 不斉反応 不斉合成 , 2002-
学歴
出身大学院
1998 , 関西学院大学 , 理学研究科 , 化学

出身学校・専攻等(大学院を除く)
1993 , 関西学院大学 , 理学部

取得学位
博士(理学) , 関西学院大学
受賞学術賞
2005 , 有機合成化学協会東海支部奨励賞
研究職歴等
研究職歴
2018- , 教授
2007-2018 , 准教授
2003-2007 , 信州大学 助手
2002-2003 , 関西学院大学 博士研究員
2000-2002 , 理化学研究所 基礎科学特別研究員
1998-2000 , ピッツバーグ大学 博士研究員
1997-1999 , 日本学術振興会 特別研究員

研究活動業績

研究業績(著書・
発表論文等)
論文
From Enantioenriched Donor–Acceptor Cyclopropylcarbinols to Axially Chiral Arylnaphthalenes via Aryldihydronaphthalenes: Central-to-Axial Chirality Exchange
Eur. J. Org. Chem.,:e202101213 2022
Author:Taichi Saito, Yuka Shimizu, Yusuke Araki, Yoshino Ohgami, Yu Kitazawa, Yoshinori Nishii*
Abstract:Transformations of enantioenriched donor–acceptor (D–A) cyclopropylcarbinols to enantioenriched 1-arylnaphthalenes that bear an ortho -substituent on a benzene ring provided a successful chirality-exchange method with a high level of stereoinduction. A central-to-central chirality-transfer step, i.e., a Lewis-acid-mediated ring-opening cyclization of enantioenriched D–A cyclopropylcarbinols (97 to >99% ee), afforded 1-aryl-1,2-dihydronaphthalenes with an ortho -substituent (Me, Br, OMe, OBn, or OiPr) on the benzene ring with high enantioselectivity (97 to >99% ee). The central-to-axial chirality-exchange step, i.e., the dehydrogenation of the obtained enantioenriched 1-aryl-1,2-dihydronaphthalenes using DDQ, furnished the axially chiral 1-arylnaphthalenes with high enantioselectivity (97 to >99% ee). Importantly, we developed a highly enantioselective synthesis of a 1-arylnaphthalene with an ortho -alkoxy group on the benzene ring. Moreover, we improved the chirality exchange to furnish a 1-arylnaphthalene with an ortho ­–alkoxy-substituted benzene ring in high yield with high ee. In addition, we also elucidated the reaction mechanism based on the determination of the absolute configuration, spectral data using NOE, and theoretical calculations.


Asymmetric total synthesis of four bioactive lignans using donor–acceptor cyclopropanes and bioassay of (-)- and (+)-niranthin against hepatitis B and influenza viruses
RSC Advances,12:4635-4639 2022
Author:Ryotaro Ota, Daichi Karasawa, Mizuki Oshima, Koichi Watashi, Noriko Shimasaki, and Yoshinori Nishii*
Abstract:The asymmetric total synthesis of four lignans, dimethylmatairesinol, matairesinol, (-)-niranthin, and (+)-niranthin has been achieved using reductive ring-opening of cyclopropanes. Moreover, we performed bioassays of the synthesized (+)- and (-)-niranthins using hepatitis B and influenza viruses, which revealed the relationship between the enantiomeric structure and the anti-viral activity of niranthin.


Asymmetric Total Synthesis of a Bioactive Lignanamide Using a 5-endo-tet-type Cyclization of Activated Cyclopropylcarbinols and Synthetic Support for the Reaction Mechanism
Eur. J. Org. Chem.,:e202200563 2022
Author:Taichi Saito, Kazuki Shibata, Ryohei Takagi, Yuka Shimizu, Naoya Takaki, and Yoshinori Nishii*
Abstract:This full paper is accepted as 'Very Important Paper' in EurJOC. The first enantioselective total synthesis of a bioactive lignanamide was achieved with high enantiomeric excess. Key synthetic steps include an organocatalytic enantioselective cyclopropanation and a Lewis-acid-mediated chirality-transferring 5-endo-tet-type cyclization that proceeds with a very high degree of stereoinduction. The proposed mechanism of the key reaction is supported by the experimental results. Based on these experimental results, the 5-endo-tet-type cyclization of a cyclopropylcarbinol proceeds predominantly via an SN1 mechanism with high trans-selectivity, which arises from the steric hindrance of the neighboring substituent. Minor pathways include the anchimeric participation of (i) the oxygen atom of the benzoyl group in an SN2 mechanism and/or (ii) a benzene-coordinated transition state in an SN1-like mechanism.


ドナー・アクセプター置換シクロプロパンの環開裂を伴う分子内環化と分子間付加:SN1およびSN2機構を利用する高立体選択的合成
有機合成化学協会誌,76(9):922-937 2018
Author:西井良典


ポドフィリックアルデヒドの全合成における中間体の反応性の計算化学的考察
J. Comput. Chem. Jpn.,16(4):102-105 2017
Author:三原陽子, 森川大*, 野村泰志, 西井良典


An asymmetric total synthesis of tupichilignan A using donor-acceptor cyclopropanes: a structural revision of tupichilignan A
Asian J. Org. Chem.,6:977-980 2017
Author:Yumi Kimura, Yoshitomo Sone, Taichi Saito, Takehito Mochizuki, and Yoshinori Nishii*


Catalytic hydrogenolysis of enantioenriched donor-acceptor cyclopropanes using H2 and Palladium on charcoal
Eur. J. Org. Chem.,:2842-2847 2017
Author:Yoshitomo Sone, Yumi Kimura, Ryotaro Ota, Takehito Mochizuki, Junki Ito and Yoshinori Nishii*


A formal homo-Nazarov cyclization of enantioenriched donor-acceptor cyclopropanes and following transformations: asymmetric synthesis of multi-substituted dihydronaphthalenes
Org. Biomol. Chem.,15:2443-2449 2017
Author:Seijiro Takada, Naoya Takaki, Kenta Yamada, and Yoshinori Nishii*


Stereochemical courses and mechanisms of ring-opening cyclization of donor-acceptor cyclopropylcarbinols and cyclization of 7-benzyloxy dibenzyl lignan lactones
Chem. Lett.,46:524-527 2017
Author:Takada, seijiro; Sasazawa, Kazuya; Yubune, Toshihide; Takaki, Naoya; Ota, Ryotaro; Nishii, Yoshinori*


Cu-catalyzed 1,5-addition of Grignard reagents to enantioenriched donor-acceptor cyclopropanes with inversion
Asian J. Org. Chem.,5:1225-1229 2016
Author:S. Takada, T. Saito, K. Iwata, Y. Nishii*
Keywords:cyclopropane


Stereoselective oxy-homo-Michael reactions of enantioenriched bicyclic donor–acceptor cyclopropanes to afford optically active trans-α,β-disubstituted γ-butyrolactones possessing three serial chiral centers
Tetrahedron Lett.,57:2422-2425 2016
Author:Seijiro Takada, Kiitsu Iwata, Toshihide Yubune, and Yoshinori Nishii*


多置換シクロプロパンの高立体選択的合成と不斉伝搬環拡大反応
有機合成化学協会誌,73(7):701-712 2015
Author:西井良典


Highly Stereoselective C-C Bond-Forming Reactions on Cyclopropane Rings using 1-(Methoxycarbonyl)cyclopropylzinc bromides
Chem. Lett.,44:818-820 (open access) 2015
Author:D. Sakuma, K. Yamada, K. Sasazawa and Y. Nishii*


First Total Synthesis of(+)-Podophyllic Aldehydes
Chem. Lett.,44:297-299 (open access article) 2015
Author:Junki Ito, Daichi Sakuma, and Yoshinori Nishii*


Total Synthesis of (±)-Cyclogalgravin and its Dicarboxyl Analog Using Sc(OTf)3-Mediated Highly Diastereoselective Ring Expansion of 1-(Arylhydroxymethyl)cyclopropanecarboxylates
Chem. Lett.,43:610-611 (open access article) 2014
Author:Daichi Sakuma, Junki Ito, Ryo Sakai, Ryota Taguchi, Yoshinori Nishii*


First Total Synthesis of (±)-6'-Methoxyretrojusticidin B Using Regiocontrolled Benzannulation: structural Inconsistency with Procumphthalide A and Its Revisionto 5'-Methoxyretrochinensin
Synlett,15:2275-2278 2010
Author:Yoshida, E.; Yamashita, D.;Sakai, R.; Tanabe, Y.; and Nishii, Y*.


Lewis Acid-mediated Highly Regioselective Ring-expansion of Methyl 2-Phenyl-1-(arylhydroxymethyl)cyclopropanecarboxylates
Chem. Lett.,39:194-195 (open access article) 2010
Author:E. Yoshida, K. Nishida, K. Toriyabe, R.Taguchi, J. Motoyoshiya, Y. Nishii*


Chemiluminescence of 9-benzylidene-10-methylacridans with electron-donating groups by chemically generated singlet oxygen- Application to metal ion sensing usingazacrowned compound
Bioluminescence and Chemiluminescence,:237-240 2009
Author:J. Motoyoshiya, T. Tanaka, M. Kuroe, Y. Nishii.


First total synthesis of theopederin B
Tetrahedron Lett.,50:3597-3600 2009
Author:Y. Nishii, T. Higa, S. Takahashi, T. Nakata


Toward a Chemiluminescent Molecular Device: Metal Ion-Enhanced Chemiluminescence of Benzylidenacridan with 15-Monoazacrown-5
J. Org. Chem.,74(3):1014-1018 2009
Author:Motoyoshiya, J.; Tanaka,T.; Kuroe, M.; and Nishii, Y.


Highly Stereoselective C-Silylation and Alkylation of 1-Chlorocyclopropanecarboxylic Ester Using SmI2
Chem. Lett.,38:1078-1079 2009
Author:E. Yoshida, T. Nagano, J. Motoyoshiya, Y. Nishii*


Fluorescence quenching of versatile fluorescent probes based on strongly electron-donating distyrylbenzenes responsive to aromatic chlorinated and nitro compounds, boronic acid and Ca2+
Spectrochimica Acta part A:,69:167-173 2008
Author:J. Motoyoshiya, Z. Fengqiang, Y. Nishii, H. Aoyama


SmI2-Promoted Reformatsky-Type Reaction and Acylation of Alkyl 1-Chlorocyclopropancarboxylates
Org. Lett.,10:5453-5456 2008
Author:T. Nagano, J. Motoyoshiya, A. Kakehi, Y. Nishii*


Practical, general, and systematic method for optical resolution of gem-dihalo- and monohalo cyclopropanecarboxylic acids utilizing chiral 1,1’-binaphtholmonomethyl ethers: Application to the synthesis of three chiral pesticides
Org. Biomol. Chem.,6:540-547 2008
Author:H. Yasukochi, T. Atago, A. Tanaka, H. Nakatsuji, E. Yoshida, A. Kakehi, Y. Nishii, Y. Yanabe


Chemiluminescence of 4-styrylphthalhydrazides with crown etheras ionophore
Luminescence,23:37-41 2008
Author:J. Motoyoshiya, M. Hotta, Y. Nishii, H. Aoyama


Synthesis of Hypericin via Emodin Anthrone Derived from a Two-fold Diels-Alder Reaction of 1,4-Benzoquinone
Natural Prod. Commun.,2:67-70 2007
Author:J. Motoyoshiya, Y. Masue, Y. Nishi, H. Aoyama


Highly Stereoselective Radical Carbonylations of gem-Dihalocyclopropnane Derivatives with CO
Org. Lett.,9:563-566 2007
Author:Yoshinori Nishii*, Takao Nagano, Hideki Gotoh, Ryohei Nagase, Jiro Motoyoshiya, Hiromu Aoyama, Yoo Tanabe*


Synthesis of Unsymmetrically and Highly Substituted Thiophenes Utilizing Regioselective Ring-expansion of gem-Dichlorocyclopropyl Ketones with Lawesson's Reagent
Chem. Lett.,36(1):62-63 2007
Author:Takao Nagano, Hiroki Kimoto, Hidefumi Nakatsuji, Jiro Motoyoshiya, Hiromu Aoyama, Yoo Tanabe,* Yoshinori Nishii*


A 1,4-distyrylbenzene Bearing Donor-Acceptor Substituent as a fluorescence Probe Responsive to Protic Solvents
ITE Letters,7:593-596 2006
Author:J. Motoyoshiya, T. Yokozeki, Z. Fengqiang, Y. Nishii, H. Aoyama


Unprecedented chemiluminescence behaviour during peroxyoxalate chemiluminescence of oxalates with fluorescent or electron-donating aryloxy groups
LUMINESCENCE,21(3):164-173 2006
Author:Koike, R; Kato, Y; Motoyoshiya, J; Nishii, Y; Aoyama, H


Different photochemical behavior of bis(biphenyl)ethylenes and ethenes in solution and in the solid-state: Structurally controlled Z/E-photoisomerization in the solid-state
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,184(1-2):44-49 2006
Author:Zhu, FQ; Motoyoshiya, J; Nishii, Y; Aoyama, H; Kakehi, A; Shiro, M


Photochemical behavior of some p-styryistilbenes and related compounds: Spectral properties and photoisomerizationin solution and in solid state
PHOTOCHEMISTRY AND PHOTOBIOLOGY,82(6):1645-1650 2006
Author:Zhu, FQ; Motoyoshiya, J; Nakamura, J; Nishii, Y; Aoyama, H


Synthesis of 4-Styrylphthalhydrazides and Their Chemiluminescence Reaction. Emitters and Chemiluminescence Efficiency Highly Dependent on Electronic Nature of Styryl Goups
J. Heterocyclic Chem.,42:1063-1068 2005
Author:Jiro Motoyoshiya, Kazuya Yokota, Takuro Fukami, Shoji Konno, AyaYamamoto, Masanori Hotta, Ryu Koike, Sachiko Yoshioka, Yoshinori Nishii, and Hiromu Aoyama


Regiocontrolled benzannulation of diaryl (gem-dichlorocyclopropyl)methanols for the synthesis of unsymmetrically substituted alpha-arylnaphthalenes: Application to total synthesis of natural lignan lactones
JOURNAL OF ORGANIC CHEMISTRY,70(7):2667-2678 2005
Author:Nishii, Y; Yoshida, T; Asano, H; Wakasugi, K; Morita, J; Aso, Y; Yoshida, E; Motoyoshiya, J; Aoyama, H; Tanabe, Y


Poly(benzyl ether) dendrimers with strongly fluorescent distyrylbenzene cores as the fluorophores for peroxyoxalate chemiluminescence: insulating effect of dendritic structures on fluorescent sites
TETRAHEDRON,61(46):11020-11026 2005
Author:Koike, R; Katayose, Y; Ohta, A; Motoyoshiya, J; Nishii, Y; Aoyama, H


エステル化・スルホニル化・アミド化・シリル化:汎用反応の実用的合理化
有機合成化学協会誌,62:1249-1259 2004(Dec.)
Author:田辺陽,御前智則,飯田聖,西井良典


中心不斉から軸不斉への転写と変換
化学と工業,57:1212 2004(Nov.)
Author:西井良典


Chemiluminescent Autoxidation of alpha-Silyl Carbanios Derived From 9-Silyl-10-Methylacridanes
Heterocycles,:1667-1672 2004
Author:Jiro Motoyoshiya, Kunihiko Tokutake, Motoki Kuroe, Sachiko Yoshioka, Yoshinori Nishii, and Hiromu Aoyama


A Facile Synthesis of the Angucyclinone Antibiotic (+)-Rubiginone B2 Involving the BF3-Mediated Diels-Alder Reaction of Juglone
Synthesis,:2099-2102 2004
Author:Jiro Motoyoshiya, Yusuke Masue, Gento Iwayama, Sachiko Yoshioka, Yoshinori Nishii, and Hiromu Aoyama


Chirality Exchange from sp3 Central Chirality to Axial Chirality: Benzannulation of Optically Active Diaryl-2,2-dichlorocyclopropylmethanols to Axially Chiral alpha-Arylnaphthalenes
J. Am. Chem. Soc.,126:5358-5359 2004
Author:Yoshinori Nishii, Kazunori Wakasugi, Keisuke Koga, Yoo Tanabe


Reactions of 9-Phosphorylacridines with Aqueous Hydrogen Peroxide Accompained by Weak Chemiluminescence: Remarkable Substituent Effect on Emission Efficiency
Heterocycles,60:2543-2549 2003
Author:Jiro Motoyoshiya, Rie Shima, Yutaka Takaguchi, Yoshinori Nishii, and Hiromu Aoyama


Simple, Mild, and Practical Esterification, Thioesterification, and Amide Formation Utilizing p-Toluenesulfonyl Chloride and N-Methylimidazole
Adv. Synth. Catal.,345:1209-1214 2003
Author:K. Wakasugi, Akira Iida, T. Misaki, Y. Nishii, Y. Tanabe


Novel and efficient method for esterification, amidation between carboxylic acids and equimolar amounts of alcohols, and amines utilizing Me2NSO2Cl and N,N-dimethylamines; Its application to the synthesis of coumaperine, a natural chemopreventivedieneamide
Tetrahedron,59:5337-5345 2003
Author:K. Wakasugi, A. Nakamura, A. Iida, Y. Nishii, N. Nakatani, S. Fukushima, and Y. Tanabe


Practical Short-step Synthesis of 1b?Methylcarbapenem Utilizing a New Dehydration Ti-Dieckmann Condensation
Adv. Synth. Catal.,345:967-970 2003
Author:Y. Tanabe, N. Manta, R. Nagase, T. Misaki, Y. Nishii, M. Sunagawa, and A. Sasaki


Efficient One-step Synthesis of Trialkylsubstituted 2(5H)-Furanone Utilizing Direct Ti-Crossed Aldol Condensation and Its Application to the Straightforward Synthesis of (R)-Mintlactone and (R)-Menthofuran
Chem. Commun.,:2542-2545 2002
Author:Y. Tanabe, K. Mitarai, T. Higashi, T. Misaki and Y. Nishii


Direct, Practical, and Powerful Crossed Aldol Additions between Ketones and Ketones or Aldehydes Utilizing Environmentally Benign TiCl4 - Bu3N Reagent
Tetrahedron (Symposium-in-print),58:8269 2002
Author:Y. Tanabe, N. Matsumoto, T. Higashi, T. Misaki, T. Itoh, M. Yamamoto, K. Mitarai, and Y. Nishii


Total synthesis of pederin, an insect toxin: an efficient synthesis of the right half, (+)-benzoylpedamide
Tetrahedron (Symposium-in-print),58:6359 2002
Author:T. Takemura, Y. Nishii, S Takahasi, J. Kobayashi, and T. Nakata


Silazanes / catalytic bases: Mild, powerful and chemoselective agents for the preparation of enol silyl ethers from ketones and aldehydes
Chem. Commn.,:1628 2002
Author:Yoo Tanabe, T. Misaki, M. Kurihara, A. Iida, and Y. Nishii


Stereoselective Bifurcating-type Radical Cyclization of gem-Dibromocyclopropanes for the Synthesis of Uniquely Fused 5-3-5-Type Tricyclic Compounds
Chem. Lett.,:30-31 2002
Author:Y. Nishii, A. Fujiwara, K. Wakasugi, K. Yanagi, M. Miki, and Y. Tanabe


ピレスロイド殺虫剤:ミステリアスな立体構造活性相関
化学と生物,39:782 2001
Author:田辺 陽・西井良典


Synthesis and Stereostructure-Activity Relationship of Three Asymmetric Center Pyrethroids: 2-Methyl-3-phenylcyclopropyl-methyl 3-Phenoxybenzyl Ether and Cyanohydrin Ester
Bioorg. Med. Chem.,9:33 2001
Author:Y. Nishii, N. Maruyama, K. Wakasugi and Y. Tanabe


Cyclopropane-shift type reaction of diaryl(2-halogenocyclopropyl)methanols promoted by Lewis acids
Tetrahedron Lett.,41:5937 2000
Author:K. Wakasugi, Y. Nishii, and Y. Tanabe


Does the Facile Reductive Rearrangement of 2-Allyloxycyclohexenone with Bu3SnH Occur by a Radical-Accelerated Claisen Rearrangement or an Stannyloxy-Accelerated Claisen Rearrangement?
J. Am. Chem. Soc.,121:8955-8956 1999
Author:D. P. Curran and Y. Nishii


gem-ジハロシクロプロパンの特徴を生かした反応と合成:カチオン的ベンズアヌレーション
有機合成化学協会誌,57:170-180 1999
Author:田辺 陽, 西井 良典


Dimethylation and Hydrodechlorination of gem-Dihalocyclopropaneswith Grignard Reagents Promoted by Fe(III) or Co(II) Catalysts
Synlett,:67-69 1998
Author:Y. Nishii, K. Wakasugi, and Y. Tanabe


Total Synthesis of (-)-Periplanones C and D. Their Pheromonal Activities against Three Periplaneta Species
Tetrahedron,53:7209 1997
Author:Y. Nishii, K. Watanabe, T. Yoshida, T. Okayama, S. Takahashi, and Y. Tanabe


Enantiomeric Resolution of a Germacrene-D Derivative by Chiral High-performance Liquid Chromatography
Biosci. Biotech. Biochem,61:547 1997
Author:Y. Nishii, T. Yoshida, and Y. Tanabe


Sequential and Regioselective Friedel-Crafts Reactions of gem-Dihalocyclopropanecarbonyl Chlorides with Benzenes for the Synthesis of 4-Aryl-1-naphthol Derivatives
J. Chem. Soc., Perkin Trans. 1,:477-486 1997
Author:Y. Nishii and Y. Tanabe


Regiocontrolled Benzannulation of Diaryl(gem-dichlorocyclopropyl)methanols for the Synthesis of "Unsymmetrically" Substituted a-Arylnaphthalenes
Tetrahedron Lett.,38:7195-7198 1997
Author:Y. Nishii, T. Yoshida, and Y. Tanabe


Novel Method for the Synthesis of a- and b-Halonaphthalenes via Regioselective Ring Cleavage of Aryl (gem-dihalocyclopropyl)methanols. Application to Total Synthesis of Lignan Lactones, Justicidin E and Taiwanin C
J. Chem. Soc., Perkin Trans. 1,:2157 1996
Author:Y. Tanabe, S. Seko, Y. Nishii, T. Yoshida, N, Utsumi, and G, Suzukamo


Synthesis and Stereostructure-activity Relationship of a Synthetic pyrethroid, 2-Chloro-1-methyl-3-phenylcyclopropylmethyl 3-Phenoxybenzyl Ether
J. Chem. Soc., Perkin Trans. 1,:1243-1249 1996
Author:Y. Nishii, K. Wakimura, T. Tsuchiya, S. Nakamura and Y. Tanabe


Sequential and Highly Stereoselective Intermolecular Radical Additions of 2,3-cis-Disubstituted 1,1-Dibromo- and 1-Bromocyclopropanes to Electron-Deficient Olefins
Tetrahedron Lett.,37:1837-1840 1996
Author:Y. Tanabe, K. Wakimura and Y. Nishii


Synthesis of 2,5-Diaryl-3-halofurans via Regioselective Ring Cleavage of 2-Aryl-3,3-dihalocyclopropyl Aryl Ketones
Synthesis,:338 1996
Author:Y, Tanabe, K. Wakimura, Y, Nishii, and Y, Muroya


Regioselective Cyclocondensation of Chlorocarbonylsulfenyl Chloride with Hydrazones: Efective Synthesis of a Class of Sulfur and Nitrogen Containing Heterocycles with -COS- Linkage
Heterocycles,43:141 1996
Author:Y. Tanabe, K. Mori, and Y. Nishii


Synthesis of Perhydoro-1,3,4-thiadiazin-5-ones and 3-Arylaminothiazolidin-4-ones by the Regioselective Cyclocondensation of 2-Sulfanylalkanoic Acids or Their Silyl Esters with Methyl and Aryl hydrazones
Heterocycles,41:2033 1995
Author:Y. Tanabe, M. Nagaosa, Y. Nishii, and Y, Muroya


Sequential and Regioselective Friedel-Crafts Reaction of gem-Dihalocyclopropanecarbonyl Chlorides with Benzenes for the Synthesis of 4-Aryl-1-naphthol Derivatives
Tetrahedron Lett.,36:8803-8806 1995
Author:Y. Nishii and Y. Tanabe


Synthetic Pyrethroid Containing Halocyclopropane Structure
Biosci. Biotech. Biochem.,59:1335-1336 1995
Author:Y. Nishii, H. Matsumura,Y. Muroya, T. Tsuchiya, Y. Tanabe


A Novel and Regioselective Radical Cyclization of gem- Dihalocyclopropyl Substituted Alkenes and Alkynes
Chem. Lett.,:1757-1760 1994
Author:Y. Tanabe, Y. Nishii, and K. Wakimura,


講演・口頭発表等
シクロプロパンの特性を生かした高選択的合成法の開発と生理活性物質合成への応用
第27回農薬デザイン研究会 2012
Presenter:西井良典


Organic synthesis of biologically active compounds toward the chemical protection of textile
2nd Asian Protective Clothing Conference 2011
Presenter:Yoshinori NISHII, Ryo SAKAI, Eri YOSHIDA, Yoo TANABE


SmI2-Promoted Reformatsky-Type Reaction of Alkyl 1-Chlorocyclopropanecarboxylates
5th International Conference on Adovanced Fiber/Textile Materials 2009 in Ueda. 2009
Presenter:E. Yoshida, T. Nagano, Y. Nishii, J. Motoyoshiya


Chemiluminescence contolled by interaction of ligands and metal ions
18th International Symposium on the Photochemistry and Photophysics of Coordination Compounds 2009
Presenter:J. Motoyoshiya, T. Maruyama, R. Arai, Y. Nishii


Chemiluminescence of 9-benzylidene-N-methylacridans with electron-donating groups by chemically generated singlet oxygen. Application to metal ion sensing using azacrowned compound
15th International symposium on Bioluminescence and chemiluminescence 2009
Presenter:J. Motoyoshiya, T. Tanaka, M. Korue, Y. Nishii


Synthetic Studies utilizing Cyclopropanes,
3rd International Symposium on High-Tech Fiber Engineering 2009 2009
Presenter:Y. Nishii


SmI2-Promoted Reformatsky-Type Reaction of Alkyl 1-Chlorocyclopropanecarboxylates
15th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS15) 2009
Presenter:Y. Nishii, E. Yoshida, T. Nagano, J. Motoyoshiya


Synthetic study for novel biologically active compounds aiming to functionalized fibers (2) : Highly regiocontrolled ipso-type and chirality exchange benzannulation of chiral diaryl gem-dichlorocycro­propylmethanols and its application to total synthesis of axially chiral natural lignan lactones (antiviral, anti-HIV and antidepressant activity)
4th International Conference on Advanced Fiber/Textile Materials 2007 in Ueda (ICAFTM2007) 2007
Presenter:E. Yoshida, D. Yamashita, J. Motoyoshiya, Y. Nishii


Synthetic study for novel biologically active compounds aiming to functionalized fibers (1) :Radical carbonylation and ring-expansion of gem-dichlorocyclopropanes for the synthesis of pyrethroids and b-amyloid plaque imaging reagent
4th International Conference on Advanced Fiber/Textile Materials 2007 in Ueda (ICAFTM2007) 2007
Presenter:T. Nagano, H. Kimoto, Y. Yamanaka, J. Motoyoshiya,Y. Nishii


MISC
ドナー・アクセプター型シクロプロパンの高立体択的反応の開発とリグナン全合成への応用
理研シンポジウム 第18回分析・解析技術の最先端 2017( 2月)
Author:西井良典

共同研究等希望テーマ
医農薬リード化合物の合成と構造活性相関
生理活性有機化合物の全合成 , 有機合成 , 生理活性有機化合物の合成
高選択的有機合成反応の開発 , 有機反応 , 効率的・高選択的有機合成反応の開発
研究費
共同研究
2020 - , 抗ウィルス活性化合物の探索と防護服への応用
2016 - , サクラマスフェロモンとその類縁体を用いる構造活性相関研究

受託研究
2015 - 2016 , 壁剤の有機物質吸着効果
2009 - 2011 , 新規農薬の合成と探索
2007 - 2008 , 農業用殺菌剤の創製

科学研究費補助金(研究代表者)
2018 - 2020 , 多置換 D-A シクロプロパンの不斉合成と環開裂を鍵とする高選択的有機合成 , 基盤研究 (C)
2015 - 2017 , 四置換シクロプロパンの不斉合成と不斉伝搬を鍵とする高選択的有機合成 , 基盤研究 (C)
2011 - 2013 , シクロプロパン開裂を鍵とする高選択的有機合成反応の開発 , 基盤研究 (C)
2008 - 2010 , 炭素ー塩素結合切断を鍵とする高選択的有機合成反応の開発 , 基盤研究 (C)
2005 - 2007 , 光学活性 gem-ジハロシクロプロパンの構築とその特徴を生かした不斉反応の開発 , 若手研究 (B)

教育活動実績

授業等
2016 , 前期 , 有機化学 I
2016 , 前期 , 応用化学実験 III
2016 , 前期 , 機器分析化学
2016 , 後期 , 有機反応化学特論
2016 , 後期 , 有機化学 IV
2011 , 前期 , 有機化学 II