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関口和  セキグチ ノドカ

教員組織電話番号
教育組織医学部 医学科 血液・腫瘍内科学FAX番号
職名特任准教授メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

更新日:2022/07/26

プロフィール

研究分野
血液内科学
キーワード:血液内科
現在の研究課題
NK/T細胞リンパ腫・白血病の病態解明
キーワード:NK/T細胞リンパ腫・白血病
所属学会
所属学会
日本内科学会
日本血液学会
日本臨床腫瘍学会
日本リンパ網内系学会
学歴
出身学校・専攻等(大学院を除く)
2002 , 北里大学

取得学位
医学博士

研究活動業績

研究業績(著書・
発表論文等)
論文
CCR4-positive peripheral T-cell lymphoma presenting as eosinophilic pneumonia and developing from prolonged pustular psoriasis
J Int Med Res,49(2) 2021
Author:Sekiguchi N, Komatsu M, Ichiyama T, Kobayashi A, Gomi D, Fukushima T, Kobayashi T, Noguchi T, Nakazawa H, Asano N, Ishida F, Koizumi T


National incidence and initial therapy for thymic carcinoma in Japan: based on analysis of hospital-based cancer registry data, 2009-2015
Jpn J Clin Oncol,50(4):434-439 2020
Author:Koizumi T, Otsuki K, Tanaka Y, Noguchi T, Fukushima T, Kobayashi T, Ozawa T, Nodoka S, Hamanaka K


A Rare Distant Metastasis of Papillary Cystadenocarcinoma Arising from Maxillary Gingiva
Case Rep Oncol,132(2) 2020
Author:Nishimaki F, Gibo T, Tsukada K, Noguchi T, Fukushima T, Kobayashi T, Nodoka S, Ozawa T, Koizumi T


Giant paratesticular liposarcoma with lung metastases: a case report and review of the literature
J Med Case Rep,14(1):86 2020
Author:Noguchi T, Fukushima T, Hara H, Sekiguchi N, Kobayashi T, Ozawa T, Gomi D, Koizumi T


Experiences of trastuzumab plus paclitaxel combination therapy in metastatic human epidermal growth factor receptor 2-positive extramammary Paget's disease: Four cases and a review
J Dermatol,47:1276-1279 2020
Author:Sekiguchi N, Kubota S, Noguchi T, Fukushima T, Kobayashi T, Kanda S, Koizumi T, Miyake T, Shirai T, Okuyama R


「健康寿命延伸ボックス」を用いたがん化学療法の毒性軽減効果
信州医学雑誌,67(2):105-111 2019(Apr. 10)
Author:宮川 真理子、野口 卓郎、福嶋 敏郎、小沢 岳澄、小林 孝至、関口 和、間宮 敬子、小泉 知展、内川 順子


Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target
Nat Commun,9(1):1567 2018
Author:Dufva O, Kankainen M, Kelkka T, Sekiguchi N, Awad SA, Eldfors S, Yadav B, Kuusanmäki H, Malani D, Andersson EI, Pietarinen P, Saikko L, Kovanen PE, Ojala T, Lee DA, Loughran TP Jr., Nakazawa H, Suzumiya J, Suzuki R, Ko YH, Kim WS, Chuang SS, Aittokallio T, Chan WC, Ohshima K, Ishida F, Mustjoki S


Successful Salvage Chemotherapy with Mediastinal Atypical Carcinoid Tumor Who Had Relapsed after Various Prior Therapies
Case Rep Oncol,11:49-54 2018
Author:Fukushima T, Gomi D, Seno N, Gibo T, Kobayashi T, Sekiguchi N, Matsushita H, Kasahara Y, Mamiya K, Koizumi T


Gastric cancer initially presenting as bone metastasis: Two case reports and a literature review
Oncol Lett,16:5863-5867 2018
Author:Gomi D, Fukushima T, Kobayashi T, Sekiguchi N, Sakamoto A, Mamiya K, Koizumi T


Signet Ring Cell Carcinoma of Unknown Primary Origin Detected Incidentally by Lymph Node Purification for Thyroid Carcinoma
Intern Med,57(1):31-35 2018
Author:Handa H, Gomi D, Fukushima T, Kobayashi T, Sekiguchi N, Sakamoto A, Tsukahara Y, Matsushita H, Sasaki S, Mamiya K, Koizumi T, Ichiyama T


Frequent STAT3 mutations in CD8+ T cells from patients with pure red cell aplasia
Blood Adv,2(20):2704-2712 2018
Author:Kawakami T, Sekiguchi N, Kobayashi J, Imi T, Matsuda K, Yamane T, Nishina S, Senoo Y, Sakai H, Ito T, Koizumi T, Hirokawa M, Nakao S, Nakazawa H, Ishida F


Development of angiosarcoma in a mediastinal non-seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy
Thoracic Cancer,10(1):111-115 2018
Author:Matsuoka S, Koyama T, Takeda T, Yamada K, Hyogotani A, Hamanaka K, Sekiguchi N, Koizumi T


Intradiaphragmatic Bronchogenic Cysts: A Case Report and Literature Review
OMICS J Radiol,7(1):1000289 2018
Author:Sekiguchi N, Gomi D, Noguchi T, Kobayashi T, Koizumi T, Fujita A, Kawakami S


A screening method with lymphocyte percentage and proportion of granular lymphocytes in the peripheral blood for large granular lymphocyte (LGL) leukemia
J Clin Oncol,35(1):32-39 2017
Author:Tanahashi T, Sekiguchi N, Matsuda K, Matsumoto A, Ito T, Nakazawa H, Ishida F


Treatment of metastatic refractory colorectal cancer following regorafenib failure
Mol Clin Oncol,7(2):308-312 2017
Author:Takeuchi N, Koike K, Yoshida S, Kubo A, Sekiguchi N, Nakayama A, Kubota K, Rokuhara T, Kitahara M


Successful treatment with doxorubicin and ifosfamide for mediastinal malignant peripheral nerve sheath tumor with loss of H3K27me3 expression
Thorac Cancer,8(6):720-723 2017
Author:Seno N, Fukushima T, Gomi D, Kobayashi T, Sekiguchi N, Matsushita H, Ozawa T, Tsukahara Y, Mamiya K, Koizumi T, Sano K


Oral cyclophosphamide was effective for Coombs-negative autoimmune hemolytic anemia in CD16+CD56- chronic lymphoproliferative disorder of NK-cells
Int J Hematol,105(6):854-858 2017
Author:Sekiguchi N, Nishina S, Kawakami T, Sakai H, Senoo N, Senoo Y, Ito T, Saito H, Nakazawa H, Koizumi T, Ishida F


Plasma L-carnitine levels in terminally ill cancer patients receiving only palliative care
Ann Palliat Med,6(1):52-57 2017
Author:Sakamoto A, Tsukahara Y, Gomi D, Fukushima T, Kobayashi T, Matsushita H, Sekiguchi N, Mamiya K, Koizumi T


Relapsed and unresectable inflammatory myofibroblastic tumor responded to chemotherapy: A case report and review of the literature
Mol Clin Oncol,7:521-524 2017
Author:Maruyama Y, Fukushima T, Gomi D, Kobayashi T, Sekiguchi N, Sakamoto A, Sasaki S, Mamiya K, Koizumi T


Correlation of early PET findings with tumor response to molecular targeted agents in patients with advanced driver-mutated non-small cell lung cancer
Med Oncol,34(10):169 2017
Author:Koizumi T, Fukushima T, Gomi D, Kobayashi T, Sekiguchi N, Mamiya K, Tateishi K, Katou A, Oguchi K


Successful and long-term response to trastuzumab plus paclitaxel combination therapy in human epidermal growth factor receptor 2-positive extramammary Paget's disease: A case report and review of the literature
Mol Clin Oncol,7:763-766 2017
Author:Ichiyama T, Gomi D, Fukushima T, Kobayashi T, Sekiguchi N, Sakamoto A, Sasaki S, Mamiya K, Koizumi T, Hama Y


Dynamics of L-Carnitine in Plasma and Urine in Patients Undergoing Cisplatin Chemotherapy
Chemotherapy,62(4):225-230 2017
Author:Gomi D, Tanaka A, Fukushima T, Kobayashi T, Matsushita H, Sekiguchi N, Sakamoto A, Sasaki S, Mamiya K, Koizumi T


Effectiveness of Imatinib Mesylate Treatment in a Patient with Dermatofibrosarcoma Protuberans with Pulmonary and Pancreatic Metastases
Intern Med,55(17):2507-2511 2016
Author:Tatai T, Gomi D, Fukushima T, Kobayashi T, Sekiguchi N, Sakamoto A, Sasaki S, Koizumi T, Sano K


Cell size variations of large granular lymphocyte leukemia: Implication of a small cell subtype of granular lymphocyte leukemia with STAT3 mutations
Leukemia Research,45:8-13 2016
Author:Tanahashi T, Sekiguchi N, Matsuda K, Takezawa Y, Ito T, Kobayashi H, Ichikawa N, Nishina S, Senoo N, Sakai H, Nakazawa H, Ishida F


Alectinib-Induced Alopecia in a Patient with Anaplstic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer
Cace Rep Oncol,9:212-215 2016
Author:Koizumi T, Fukushima T, Gomi D, Kobayashi T, Sekiguchi N, Sakamoto A, Sasaki S, Mamiya K


A Case of Olfactory Neuroblastoma (Esthesioneuroblastoma) Presenting with Anemia Due to Nasal Bleeding
Shinshu Medical Journal,64(5):247-252 2016
Author:Gomi D, Sasaki S, Sekiguchi N, Kobayashi T, Sakamoto A, Koizumi T


High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia
Blood,128(20):2465-2468 2016
Author:Andersson EI, Tanahashi T, Sekiguchi N, Gasparini VR, Bortoluzzi S, Kawakami T, Matsuda K, Mitsui T, Eldfors S, Bortoluzzi S, Coppe A, Binatti A, Lagström S, Ellonen P, Fukushima N, Nishina S, Senoo N, Sakai H, Nakazawa H, Kwong YL, Loughran TP, Maciejewski JP, Mustjoki S, Ishida F


赤芽球癆を合併したT-cell large granular lymphocyte leukemia の一例
川崎医学会誌,41(1):19-26 2015
Author:藤原英世、薄聖子、近藤敏範、関口和、石田文宏、岡大五、是澤里紗、和田秀穂、杉原尚、定平吉都


LGL白血病のSTAT3遺伝子変異と併発する赤芽球癆
血液内科,70(1):93-96 2015
Author:石田文宏、関口和


Iris Metastasis of Esophageal Cancer
Intern Med,54:1941 2015
Author:Tatai T, Sasaki S, Sekiguchi N, Koizumi T


Two Cases of Thymic Carcinoma Initially Presenting as Bone Metastasis: A Clinical Report and the Usefulness of CD5 Immunohistochemistry for Assessing Bone Lesions
Internal Medicine,54:1781-1785 2015
Author:Sasaki S, Fukushima T, Maruyama Y, Gomi D, Kobayashi T, Sekiguchi N, Sakamoto A, Koizumi T, Kitano K


Primary Malignant Lymphoma of the Trigeminal Nerve: Case Report and Literature Review
World Neurosurg,84(2):592e3-7 2015
Author:Ogiwara T, Horiuchi T, Sekiguchi N, Kakizawa Y, Hongo K


Successful treatment of crizotinib-induced dysgeusia by switching to alectinib in ALK-positive non-small cell lung cancer
Lung Cancer,88:112-113 2015
Author:Koizumi T, Fukushima T, Tatai T, Kobayashi T, Sekiguchi N, Sakamoto A, Sasaki S


STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia
CANCER SCIENCE,105(3):342-346 2014(Mar.)
Author:Ishida, F; Matsuda, K; Sekiguchi, N; Makishima, H; Taira, C; Momose, K; Nishina, S; Senoo, N; Sakai, H; Ito, T; Kwong, YL


ランダム皮膚生検にて診断し得た血管内大細胞型B細胞リンパ腫の2例
信州医学雑誌,62(5):295-302 2014
Author:関口和、五味大輔、小林孝至、坂本明之、佐々木茂、伊藤俊朗、石田文宏、日根野晃代、小泉知展


Successful Salvage Chemotherapy with Amrubicin for Invasive Thymoma Associated with Myasthenia Gravis
Jpn J Clin Oncol,44(11):1120-1122 2014
Author:Fukushima T, Gomi D, Kobayashi T, Sekiguchi N, Sakamoto A, Sasaki S, Koizumi T


STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia
Cancer Sci,105:342-346 2014
Author:Ishida F, Matsuda K, Sekiguchi N, Makishima H, Taira C, Momose K, Nishina S, Senoo N, Sakai H, Ito T, Kwong Y


Screening Tests Using Serum Tissue Transglutaminase IgA May Facilitate the Identification of Undiagnosed Celiac Disease among Japanese Population
Int J Med Sci,11(8):819-823 2014
Author:Nakazawa H, Makishima H, Ito T, Ota H, Momose K, Sekiguchi N, Yoshizawa K, Akamatsu T, Ishida F


Large vessel vasculitis developed early after allogeneic bone marrow transplant for acute erythroid leukemia
Leuk Lymphoma,54(12):2748-2749 2013
Author:Kawakami T, Ito T, Sakai H, Sekiguchi N, Nakazawa H, Senoo N, Nishina S, Ishida F


Liver Dysfunction and Thrombocytopenia Diagnosed as Intravascular Large B-cell Lymphoma Using a Timely and Accurate Transjugular Liver Biopsy
INTERNAL MEDICINE,52(17):1903-1908 2013
Author:Sekiguchi, N; Joshita, S; Yoshida, T; Kurozumi, M; Sano, K; Nakagawa, M; Ito, T; Matsushita, T; Komatsu, D; Komatsu, M; Ito, T; Umemura, T; Ikeda, S; Kadoya, M; Ishida, F; Tanaka, E


Elevated serum granulysin and its clinical relevance in mature NK-cell neoplasms
Int J Hematol,96:461-468 2012
Author:Sekiguchi N, Asano N, Ito T, Momose K, Ishida F


Late relapse of extranodal natural killer/T cell lymphoma, nasal type, after more than ten years
Leukemia&Lymphoma,51(1):171-173 2010
Author:Ishida F, Nishina S, Asano N, Sasaki S, Sekiguchi N, Nakazawa H, Ito T, Shikama N


卵巣腫瘍に対してのschizophyllan投与14年後のT細胞性急性リンパ性白血病症例に認めたβDグルカン高値
内科,102(2):413-416 2008
Author:関口和、牧島秀樹、中澤英之、伊藤俊朗、石田文宏


講演・口頭発表等
Clinical characteristics of pure red cell aplasia associated with STAT3-mutated LGL Leukemia
The 75th Annual Meeting of the Japanese Society of Hematology 2013
Presenter:Sekiguchi N, Ishida F, Matsuda K Makishima H, Taira C, Nishina S, Senoo N, Sakai H, Ito T, Kwong Y


当院にて同種造血幹細胞移植を施行した悪性リンパ腫症例の検討
第64回長野県医学会 2013
Presenter:妹尾紀子、伊藤俊朗、酒井香生子、酒井均、仁科さやか、田中榮司、関口和、石田文宏


再発・難治多発性骨髄腫に対する当院でのthalidomide使用の検討
第11回日本臨床腫瘍学会 2013
Presenter:関口和、川上徹、妹尾紀子、仁科さやか、酒井均、伊藤俊朗、小泉知展、石田文宏


高齢者に発症した胸壁原発骨外性Ewing肉腫の一治療例
第11回日本臨床腫瘍学会 2013
Presenter:立石一成、福嶋敏郎、市山崇史、花岡正幸、久保惠嗣、和田洋典、佐野健司、関口和、佐々木茂、小泉知展


信州大学緩和ケアチームにおける非がん患者緩和ケアの現状と問題点
第18回日本緩和医療学会 2013
Presenter:坂本明之、関口和、佐々木茂、越由香里、加藤咲子、小泉知展


STAT3 Gene Mutations and the Association with Pure Red Cell Aplasia in Large Granular Lymphocyte Leukemia
54th ASH Annual Meeting and Exposition 2012(Dec. 08)
Presenter:Sekiguchi N, Matsuda K, Momose K, Makishima H, Ito T, Ishida F


Outcomes of patients fifty years or older receiving allogeneic HCT
第74回日本血液学会 2012(Oct. 19)
Presenter:Ito T, Kawakami T, Sakai H, Senoo N, Nishina S, Sekiguchi N, Tanaka E, Ishida F


Limited value of serial EBV viral load monitoring for the prediction of PTLD after allo-HCT with ATG
第74回日本血液学会 2012(Oct. 19)
Presenter:Sakai H, Ito T, Sekiguchi N, Nishina S, Senoo N, Matsuda K, Tanaka E, Ishida F


Characteristic complications of chronic lymphoproliferative disorder of NK-cells
第74回日本血液学会 2012(Oct. 19)
Presenter:Sekiguchi N, Ishida F, Nishina S, Sakai H, Senoo N, Momose K, Kitano K, Ito T, Sato K, Kobayashi H


Approach with L-asparaginase-containing chemotherapies and/or HSCT to NK-cell lymphoma/leukemia
第74回日本血液学会 2012(Oct. 19)
Presenter:Ishida F, Ito T, Sekiguchi N, Sakai H, Senoo N, Nishina S, Ueki T, Kobayashi H


Lytic granule protein profiles of mature NK cell neoplasms
第73回日本血液学会 2011
Presenter:Nodoka Sekiguchi, Naoko Asano, Toshiro Ito, Kiyoshi Kitano, Kayoko Momose, Masanobu Momose, Fumihiro Ishida


成熟NK細胞腫瘍における血清グラニュライシンの意義
第51回日本リンパ網内系学会総会 2011
Presenter:関口和、百瀬佳代子、伊藤俊朗、浅野直子、石田文宏


Profiles of Cytotoxic Molecules In Mature NK Cell Neoplasms
第52回米国血液学会 2010
Presenter:Nodoka Sekiguchi, Naoko Asano, Hideki Makishima, Masanobu Momose, Toshiro Ito,ShigeoNakamura, Fumihiro Ishida