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宮川眞一  ミヤガワ シンイチ

教員組織電話番号
教育組織医学部 医学科 外科学第一FAX番号
職名特任教授メールアドレスshinichi@shinshu-u.ac.jp
住所ホームページURL

更新日:2019/09/25

プロフィール

研究分野
肝胆膵外科学
移植外科学
現在の研究課題
肝胆膵領域再生医療

肝癌

免疫寛容

胆道癌

膵臓癌

所属学会
所属学会
日本外科学会
日本消化器外科学会
日本消化器病学会
日本肝胆膵外科学会
日本移植学会
日本癌学会
日本臨床外科学会
日本ヘルニア学会
学歴
出身学校・専攻等(大学院を除く)
1982 , 金沢大学

取得学位
医学博士 , 信州大学

研究活動業績

研究業績(著書・
発表論文等)
論文
Adjuvant Chemotherapy with Gemcitabine for Resected Biliary Tract Cancer: A Single-Arm Phase 2 Study
信州医学雑誌,65(2):99-111 2017(Apr. 10)
Author:Kitagawa, Noriyuki; Motoyama, Hiroaki; Kobayashi, Akira; Yokoyama, Takahide; Shimizu, Akira; Notake, Tsuyoshi; Fukushima, Kentaro; Masuo, Hitoshi; Yoshizawa, Takahiro; Tsukahara, Teruomi; Miyagawa, Shin-ichi


Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection.
,47(5):405-418 2017
Author:Kimura T, Kobayashi A, Tanaka N, Sano K, Komatsu M, Fujimori N, Yamazaki T, Shibata S, Ichikawa Y, Joshita S, Umemura T, Matsumoto A, Horiuchi A, Mori H, Wada S, Kiyosawa K, Miyagawa SI, Tanaka E.


ASC Induces Apoptosis via Activation of Caspase-9 by Enhancing Gap Junction-Mediated Intercellular Communication.
,12(1):e0169340 2017
Author:Kitazawa M, Hida S, Fujii C, Taniguchi S, Ito K, Matsumura T, Okada N, Sakaizawa T, Kobayashi A, Takeoka M, Miyagawa SI.


Surgery for chronic mesh infection occurred 10 years after sacrectomy - Mesh resection and mesentric leaf repair: A case report.
,30(1):215-217 2017
Author:Koyama M, Miyagawa Y, Yamamoto Y, Kitazawa M, Suzuki A, Ishizone S, Miyagawa S.


Adjuvant Oral Uracil-Tegafur with Leucovorin for Colorectal Cancer Liver Metastases: A Randomized Controlled Trial.
Plos One,11(9):e0162400 2016
Author:Hasegawa K, Saiura A, Takayama T, Miyagawa S, Yamamoto J, Ijichi M, Teruya M, Yoshimi F, Kawasaki S, Koyama H, Oba M, Takahashi M, Mizunuma N, Matsuyama Y, Watanabe T, Makuuchi M, Kokudo N.


Correlation between the serum levels of type IV collagen 7s domain and the risk of intractable ascites following liver resection for hepatocellular carcinoma: A propensity score-matched analysis.
Surgery,160(5):1244-1255 2016
Author:Shimizu A, Kobayashi A, Yokoyama T, Motoyama H, Sakai H, Kitagawa N, Notake T, Shirota T, Fukushima K, Miyagawa SI.


Neuroendocrine tumor of the common bile duct.
Surgery,160(2):525-526 2016
Author:Hosoda K, Kobayashi A, Shimizu A, Kitagawa N, Ito T, Yamada A, Miyagawa S.


Contrast-enhancement ratio on multiphase enhanced computed tomography predicts recurrence of pancreatic neuroendocrine tumor after curative resection.
Pancreatology,16(3):397-402 2016
Author:Arai T, Kobayashi A, Fujinaga Y, Yokoyama T, Shimizu A, Motoyama H, Kitagawa N, Notake T, Shirota T, Fukushima K, Masuo H, Kadoya M, Miyagawa S.


Effect of Application of Subcutaneous Suction Drainage with Subcuticular Sutures for Wound Closure on the Incidence of Incisional Surgical Site Infection following Elective General Abdominal Surgery : A Randomized Controlled Trial
信州医学雑誌,63(2):91-101 2015(Apr. 10)
Author:SHIMIZU, Akira; KOBAYASHI, Akira; KOIDE, Naohiko; SUZUKI, Akira; TAKEUCHI, Daisuke; YOKOYAMA, Takahide; MOTOYAMA, Hiroaki; FURUSAWA, Norihiko; TSUKAHARA, Teruomi; MIYAGAWA, Shin-ichi


Prevalence and management of colorectal neoplasia in surgically treated esophageal cancer patients.
Int J Surg. ,17:60-6 2015
Author:Takeuchi D, Koide N, Komatsu D, Suzuki A, Miyagawa S.


Postoperative complications in elderly patients with gastric cancer.
J Surg Res.,198(2):317-26 2015
Author:Takeuchi D, Koide N, Suzuki A, Ishizone S, Shimizu F, Tsuchiya T, Kumeda S, Miyagawa S.


Successful living donor liver transplantation for acute liver failure after acetylsalicylic acid overdose.
Clin J Gastroenterol. ,8(2):97-102 2015
Author:Shirota T, Ikegami T, Sugiyama S, Kubota K, Shimizu A, Ohno Y, Mita A, Urata K, Nakazawa Y, Kobayashi A, Iwaya M, Miyagawa S.


Biliary tract variations of the left liver with special reference to the left medial sectional bile duct in 500 patients.
Am J Surg. ,210(2):351-6 2015
Author:Furusawa N, Kobayashi A, Yokoyama T, Shimizu A, Motoyama H, Kanai K, Arakura N, Yamada A, Kitou Y, Miyagawa S.


Features of acute liver congestion on gadoxetate disodium-enhanced MRI in a rat model: Role of organic anion-transporting polypeptide 1A1.
J Magn Reson Imaging. ,42(3):823-36 2015
Author:Shimizu A, Kobayashi A, Motoyama H, Sakai H, Yamada A, Yoshizawa A, Momose M, Kadoya M, Miyagawa S.


Signal intensity of the pancreas on magnetic resonance imaging: Prediction of postoperative pancreatic fistula after a distal pancreatectomy using a triple-row stapler.
Pancreatology,15(4):380-6 2015
Author:Arai T, Kobayashi A, Yokoyama T, Ohya A, Fujinaga Y, Shimizu A, Motoyama H, Furusawa N, Sakai H, Uehara T, Kadoya M, Miyagawa S.


Heat Shock Protein 90 Is a Potential Therapeutic Target in Cholangiocarcinoma.
Mol Cancer Ther,14(9):1985-93 2015
Author:Shirota T, Ojima H, Hiraoka N, Shimada K, Rokutan H, Arai Y, Kanai Y, Miyagawa S, Shibata T.


Genomic spectra of biliary tract cancer.
Nat Genet.,47(9):1003-1010 2015
Author:Nakamura H, Arai Y, Totoki Y, Shirota T, Elzawahry A, Kato M, Hama N, Hosoda F, Urushidate T, Ohashi S, Hiraoka N, Ojima H, Shimada K, Okusaka T, Kosuge T, Miyagawa S, Shibata T.


Living-Donor Liver Transplantation for Hepatic Metastasis From Meningeal Hemangiopericytoma: A Case Report.T
Transplant Proc,47(7):2274-2277 2015
Author:Urata K, Ikegami T, Nakazawa Y, Ohno Y, Kobayashi A, Mita A, Sano K, Kurozumi M, Miyagawa S.


Laparoscopic repair for a previously unreported form of ventral hernia on the right iliac fossa in an elderly emaciated woman.
Hernia,19(5):841-843 2015
Author:Yokoyama T, Kobayashi A, Shimizu A, Motoyama H, Miyagawa S.


Impact of advanced age on the short- and long-term outcomes in patients undergoing hepatectomy for hepatocellular carcinoma: a single-center analysis over a 20-year period.
Am. J Surg,209(4):733-741 2015
Author:Motoyama H, Kobayashi A, Yokoyama T, Shimizu A, Sakai H, Furusawa N, Notake T, Kitagawa N, Arai T, Yokoi K, Okubo Y, Miyagawa S.


Prevalence of synchronous colorectal neoplasms in surgically treated gastric cancer patients and significance of screening colonoscopy
DIGESTIVE ENDOSCOPY,26(3):396-402 2014(May)
Author:Suzuki, A; Koide, N; Takeuchi, D; Okumura, M; Ishizone, S; Suga, T; Miyagawa, S


Optimal Initial Dose of Orally Administered Once-daily Extended-release Tacrolimus Following Intravenous Tacrolimus Therapy After Liver Transplantation
TRANSPLANTATION PROCEEDINGS,46(3):794-796 2014(Apr.)
Author:Mita, A; Ikegami, T; Masuda, Y; Katsuyama, Y; Ohno, Y; Urata, K; Nakazawa, Y; Kobayashi, A; Miyagawa, S


Liver failure after hepatocellular carcinoma surgery.
Langenbecks Arch Surg,399(8):1047-1055 2014
Author:Motoyama H, Kobayashi A, Yokoyama T, Shimizu A, Furusawa N, Sakai H, Kitagawa N, Ohkubo Y, Tsukahara T, Miyagawa S.


A combination of oral uracil-tegafur plus leucovorin (UFT + LV) is a safe regimen for adjuvant chemotherapy after hepatectomy in patients with colorectal cancer: Safety report of the UFT/LV study.
Drug Discov Ther,8(1):48-56 2014
Author:Saiura A, Yamamoto J, Hasegawa K, Oba M, Takayama T, Miyagawa S, Ijichi M, Teruya M, Yoshimi F, Kawasaki S, Koyama H, Makuuchi M, Kokudo N.


Successful active immunization using a hepatitis B virus vaccination protocol for a recipient with hepatitis B core antibody-positive liver graft.
Transplant Proc,46(3):721-5 2014
Author:Ohno Y, Mita A, Ikegami T, Masuda Y, Urata K, Nakazawa Y, Kobayashi A, Miyagawa S.


Relationships of obesity and diabetes mellitus to other primary cancers in surgically treated gastric cancer patients.
Int J Surg,12(6):587-93 2014
Author:Takeuchi D, Koide N, Komatsu D, Okumura M, Suzuki A, Miyagawa S.


Proposal to modify the International Union Against Cancer staging system for perihilar cholangiocarcinomas.
Br J Surg,101(2):79-88 2014
Author:Ebata T, Kosuge T, Hirano S, Unno M, Yamamoto M, Miyazaki M, Kokudo N, Miyagawa S, Takada T, Nagino M.


Surgical treatment of 144 cases of hilar cholangiocarcinoma without liver-related mortality.
World J Surg,38(5):1164-76 2014
Author:Furusawa N, Kobayashi A, Yokoyama T, Shimizu A, Motoyama H, Miyagawa S.


Assessment of treatment outcomes based on tumor marker trends in patients with recurrent hepatocellular carcinoma undergoing trans-catheter arterial chemo-embolization.
Int J Clin Oncol,19(5):871-9 2014
Author:Arai T, Kobayashi A, Ohya A, Takahashi M, Yokoyama T, Shimizu A, Motoyama H, Furusawa N, Notake T, Kitagawa N, Sakai H, Imamura H, Kadoya M, Miyagawa SI.


Regulation of Adrenomedullin and its Family Peptide by RAMP System - Lessons from Genetically Engineered Mice
CURRENT PROTEIN & PEPTIDE SCIENCE,14(5):347-357 2013
Author:Shindo, T; Sakurai, T; Kamiyoshi, A; Ichikawa-Shindo, Y; Shimoyama, N; Iinuma, N; Arai, T; Miyagawa, S


Treatment of a GIST patient with modified dose of sunitinib by measurement of plasma drug concentrations
ONCOLOGY LETTERS,4(3):501-504 2012
Author:Hashita, T; Katsuyama, Y; Nakamura, K; Momose, Y; Komatsu, D; Koide, N; Miyagawa, S; Nakamura, T; Yamamoto, K; Ohmori, S


Evaluation of Viable β-cell Mass is Useful for Selecting Collagenase for Human Islet Isolation: Comparison of Collagenase NB1 and Liberase HI.
Cell Transplant,21(1):39-47 2012
Author:Misawa R, Ricordi C, Miki A, Barker S, Molano RD, Khan A, Miyagawa S, Inverardi L, Alejandro R, Pileggi A, Ichii H


Pseudo-Meigs syndrome caused by sigmoid colon cancer metastasis to the ovary.
Am J Surg,203(1):e1-e3 2012
Author:Saito H, Koide N, Miyagawa S.


Transabdominal preperitoneal repair for obturator hernia.
World J Surg,35(10):2323-1327 2011
Author:Yokoyama T, Kobayashi A, Kikuchi T, Hayashi K, Miyagawa S


Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling.
Peptides,32(9):1856-1866 2011
Author:Arai T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Iesato Y, Koyama T, Yoshizawa T, Uetake R, Yamauchi A, Yang L, Kawate H, Ogawa S, Kobayashi A, Miyagawa S, Shindo T.


Portal blood flow via the peribiliary vascular plexus demonstrated by contrast-enhanced ultrasonography with Sonazoid.
J Hepatobiliary Pancreat Sci.,18(4):615-620 2011
Author:Uchikawa Y, Kitamura H, Miyagawa SI.


COP35, a Cholangiocarcinoma-Binding Oligopeptide, Interacts with the Clathrin Heavy Chain Accompanied by GRP78.
Mol Cancer Res,9(6):688−701 2011
Author:Kitahara H, Masumoto J, Parker AL, Maruta F, Kubo N, Shimizu A, Akita N, Miwa S, Kobayashi N, Nakayama J, Miyagawa S


Clinical characteristics of de novo nonalcoholic fatty liver disease following pancreaticoduodenectomy.
Gastroenterol,46(6):758-768 2011
Author:Tanaka N, Horiuchi A, Yokoyama T, Kaneko G, Horigome N, Yamaura T, Nagaya T, Komatsu M, Sano K, Miyagawa S, Aoyama T, Tanaka


Proapoptotic action of p53-Tom5 in p53-resistant A549 human non-small cell lung cancer cells through direct mitochondrial dysfunction.
Biol Pharm Bul,34(4):551-554 2011
Author:Umemoto T, Asai T, Hirashima K, Shimizu K, Mihara M, Yamamoto K, Kubota K, Miyagawa S, Oku N


Clinicopathological features of hepatitis C virus disease after living donor liver transplantation: relationship with in situ hybridisation data.
Pathology,43(2):156-160 2011
Author:Masuda Y, Nakazawa Y, Matsuda K, Sano K, Mita A, Ohno Y, Urata K, Ikegami T, Miwa S, Miyagawa S


Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver
PEPTIDES,31(5):865-871 2010(May)
Author:Iinuma, Nobuyoshi; Sakurai, Takayuki; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Arai, Takuma; Yoshizawa, Takahiro; Koyama, Teruhide; Uetake, Ryuichi; Kawate, Hisaka; Muto, Shin-ichi; Tagawa, Yoh-ichi; Miyagawa, Shinichi; Shindo, Takayuki


Disease recurrence patterns after R0 resection of hilar cholangiocarcinoma
BRITISH JOURNAL OF SURGERY,97(1):56-64 2010(Jan.)
Author:Kobayashi, A.; Miwa, S.; Nakata, T.; Miyagawa, S.


Advances in therapeutics for liver metastasis from colorectal cancer.
World J Gastrointest Oncol,2(10):380-389 2010
Author:Kobayashi A, Miyagawa S


Prognosis of Adult Patients Transplanted with Liver Grafts < 35% of Their Standard Liver Volume
LIVER TRANSPLANTATION,15(11):1622-1630 2009(Nov.)
Author:Ikegami, Toshihiko; Masuda, Yuichi; Ohno, Yasunari; Mita, Atsushi; Kobayashi, Akira; Urata, Koichi; Nakazawa, Yuichi; Miwa, Shirou; Hashikura, Yasuhiko; Miyagawa, Shinichi


A case of well-differentiated cholangiolocellular carcinoma visualized with contrast-enhanced ultrasonography using Sonazoid
HEPATOLOGY RESEARCH,39(2):207-212 2009(Feb.)
Author:Joshita, Satoru; Ichijo, Tetsuya; Suzuki, Fumitaka; Yokoyama, Takahide; Sugiyama, Yukiko; Fukushima, Mana; Kamijo, Atsushi; Komatsu, Michiharu; Umemura, Takeji; Yoshizawa, Kaname; Miyagawa, Shinichi; Tanaka, Eiji


虫垂粘液嚢胞腺腫の1例
信州医学雑誌,54(5):269-273 2006(Oct.)
Author:田中秀典, 小出直彦, 斉藤拓康, 鈴木彰, 高橋千治, 持塚章芳, 宮川眞一
Keywords:mucinous cystadenoma of the appendix, CEA, 虫垂粘液嚢胞腺腫, CEA, CA19-9


呼吸不全を伴った食道癌術後カイローマの1例
信州医学雑誌,54(4):197-201 2006(Aug.)
Author:鬼頭宗久, 小出直彦, 斉藤拓康, 鈴木彰, 花村徹, 吉田和夫, 宮川眞一
Keywords:chylothorax, chyloma, esophagectomy, 乳び胸, カイローマ, 食道切除術

研究費
共同研究
組織幹細胞と胚性幹細胞の2実験系による肝・膵細胞の分化誘導と膵β細胞への分化転換
肝臓門脈結紮(塞栓)後の代償性肝再生を応用した組織特異的肝細胞の単離とその解析
新規ペプチドを用いた胆管癌治療法の開発
ヒト成体肝幹細胞の分化・増殖に関する因子の同定と機能解析
肝細胞癌特異的結合ペプチド付加抗癌剤の開発
癌特異的結合ペプチドを用いた消化器癌に対する標的化治療
膵臓内・外分泌前駆細胞間相互作用を応用した細胞裏プログラミングとその解析
肝幹細胞を用いたインスリン産生細胞分化誘導による膵切除後無い分泌機能不全治療戦略
組織幹細胞を用いた胆汁ドレナージシステムを有する肝様組織構築と術後肝不全への応用
特異的細胞表面マーカーびよる、切除肝からの内在性幹細胞の単離
ALPPS手術後観再生促進因子の同定と機能解析

教育活動実績

授業等
2002 , 消化器外科学