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花岡 正幸  ハナオカ マサユキ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 内科学第一FAX番号
職名教授 副病院長メールアドレス
住所ホームページURL

更新日:2021/03/10

プロフィール

研究分野
閉塞性肺疾患
薬剤性肺障害
臨床遺伝学
高地医学
肺循環障害
キーワード:呼吸器内科学
現在の研究課題
慢性閉塞性肺疾患の病態解明と治療戦略の構築
キーワード:慢性閉塞性肺疾患
動物モデルを用いた肺気腫の発症機序の解明
キーワード:肺気腫
第3群肺高血圧症の病態と治療
キーワード:肺高血圧症
薬剤性肺障害の分子遺伝学的検討
キーワード:薬剤性肺障害
高地肺水腫の病態生理と発症機序
キーワード:高山病
所属学会
所属学会
日本内科学会
日本呼吸器学会
日本アレルギー学会
日本感染症学会
日本肺癌学会
日本呼吸器内視鏡学会
日本呼吸ケア・リハビリテーション学会
日本禁煙学会
日本臨床生理学会
日本登山医学会
日本肺高血圧・肺循環学会
American Thoracic Society
Asian Pacific Society of Respirology
International Society of Mountain Medicine
学歴
出身学校・専攻等(大学院を除く)
1989 , 信州大学 , 医学部

取得学位
医学博士 , 信州大学
受賞学術賞
2001 , 日本呼吸器学会奨励賞
1999 , 日本登山医学会奨励賞
研究職歴等
研究職歴
2001- , 信州大学医学部附属病院第一内科 助手

研究職歴以外の職歴
2014- , 信州大学学術研究院医学系医学部内科学第一教室 教授
2013- , 信州大学医学部内科学第一講座 教授
2008- , 信州大学医学部内科学第一講座 准教授
2003- , 信州大学医学部内科学第一講座 講師

研究活動業績

研究業績(著書・
発表論文等)
論文
Myeloperoxidase (MPO) Gene Polymorphisms are not Associated with Japanese Patients with COPD
信州医学雑誌,68(1):41-48 2020(Feb.)
Author:Ito, Michiko; Yasuo, Masanori; Droma, Yunden; Kobayashi, Nobumitsu; Hanaoka, Masayuki


Peripherally acting mu-opioid antagonist for the treatment of opioid-induced constipation: Systematic review and meta-analysis
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,34(5):818-829 2019(May)
Author:Nishie, Kenichi; Yamamoto, Shuhei; Yamaga, Takayoshi; Horigome, Naoto; Hanaoka, Masayuki;


急速に普及する加熱式たばこ・電子たばこに対する職場の対応について
信州公衆衛生雑誌,13(1):1-8 2018(Aug.)
Author:松澤幸範、花岡正幸


Usefulness of the forced oscillation technique in assessing the therapeutic result of tracheobronchial central airway obstruction
RESPIRATORY INVESTIGATION,34(5):818-829 2018(May)
Author:Yasuo, Masanori; Kitaguchi, Yoshiaki; Kinota, Fumiya; Kosaka, Makoto; Urushihata, Kazuhisa; Ushiki, Atsuhito; Yamamoto, Hiroshi; Kawakami, Satoshi; Hanaoka, Masayuki


Bevacizumab-induced tracheoesophageal fistula in a patient suffering from lung cancer with bulky subcarinal lymph node: a case report
NAGOYA JOURNAL OF MEDICAL SCIENCE,80(1):129-134 2018(Feb.)
Author:Nishie, Kenichi; Yasuo, Masanori; Kitaguchi, Yoshiaki; Kobayashi, Nobumitsu; Tateishi, Kazunari; Ushiki, Atsuhito; Urushihata, Kazuhisa; Yamamoto, Hiroshi; Ideura, Gen; Hanaoka, Masayuki;


Diversity of respiratory impedance based on quantitative computed tomography in patients with COPD
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,13:1841-1849 2018
Author:Wada, Yosuke; Kitaguchi, Yoshiaki; Yasuo, Masanori; Ueno, Fumika; Kawakami, Satoshi; Fukushima, Kiyoyasu; Fujimoto, Keisaku; Hanaoka, Masayuki;


Electron Microscopy Observation of Human Pulmonary Ultrastructure in Two Patients with High-Altitude Pulmonary Edema
HIGH ALTITUDE MEDICINE & BIOLOGY,18(3):288-291 2017(Sep. 01)
Author:Droma, Yunden; Kato, Akane; Ichiyama, Takashi; Kobayashi, Nobumitsu; Honda, Takayuki; Uehara, Takeshi; Hanaoka, Masayuki


Lack of Association of Serotonin 2A Receptor Gene in Japanese Patients with Obstructive Sleep Apnea Syndrome
信州医学雑誌,65(3):153-162 2017(Jun. 10)
Author:Ikegawa K, Ota M, Kobayashi N, Droma Yunden, Yaegashi H, Nishizawa M, Yasuo M, Urushihata K, Yamamoto H, Hanaoka M


Self-assessment of allergic rhinitis and asthma (SACRA)questionnaire-based allergic rhinitis treatment improves asthma control in asthmatic patients with allergic rhinitis.
Internal Medicine ,56:31-39 2017
Author:Yasuo M, Kitaguchi Y, Komatsu Y, Hama M,Koizumi T, Agatsuma T, Ichiyama T, Kato A,Moteki H and Hanaoka M


Gene-gene Interaction Between EPAS1 and EGLN1 in Patients with High-Altitude Pulmonary Edema
信州医学雑誌,63(3):157-165 2015(Jun. 10)
Author:HORIUCHI, Toshimichi; OTA, Masao; DROMA, Yunden; KOBAYASHI, Nobumitsu; HANAOKA, Masayuki


Pediatric Pulmonary Tuberculoma with a Solid Pulmonary Nodule Detected on Chest Computed Tomography
Intern Med,53(8):913-916 2014
Author:Ushiki, A; Yamazaki, Y; Ideura, G; Shinbo, T; Sugawara, M; Hama, M; Hanaoka, M


Primary malignant sarcomatoid mesothelioma in the pericardium
Intern Med,52:249-53 2013
Author:Tateishi K, Ikeda M, Yokoyama T, Urushihata K, Yamamoto H, Hanaoka M, Kubo K, Sakai Y, Nakayama J, Koizumi T


Additive efficacy of short-acting bronchodilators on dynamic hyperinflation and exercise tolerance in stable COPD patients treated with long-acting bronchodilators
Respir Med,107(3):394-400 2013
Author:Kitaguchi Y, Fujimoto K, Komatsu Y, Hanaoka M, Honda T, Kubo K


Clinical characteristics and outcomes of patients with small cell lung cancer detected by CT screening
MEDICAL ONCOLOGY,30(3):623 2013
Author:Fukushima, T; Tateishi, K; Yamamoto, H; Hanaoka, M; Kubo, K; Koizumi, T


Synchronous gastrointestinal stromal tumor and primary lung adenocarcinoma
Intern Med,51:2407-10 2012
Author:Wada Y, Koizumi T, Yokoyama T, Urushihata K, Yamamoto H, Hanaoka M, Kubo K


Genetic variants in EPAS1 contribute to adaptation to high-altitude hypoxia in Sherpas
PLoS One,7:e50566 2012
Author:Hanaoka M, Droma Y, Basnyat B, Ito M, Kobayashi N, Katsuyama Y, Kubo K, Ota M


Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma
Int J Chron Obstruct Pulmon Dis,7:283-9 2012
Author:Kitaguchi Y, Komatsu Y, Fujimoto K, Hanaoka M, Kubo K


IgG4-Related Pleural Disease Diagnosed by a Re-Evaluation of Chronic Bilateral Pleuritis in a Patient Who Experienced Occasional Acute Left Bacterial Pleuritis
Intern Med,50(8):893-897 2011
Author:Yamamoto, H; Suzuki, T; Yasuo, M; Kobayashi, O; Tsushima, K; Ito, M; Urushihata, K; Yamazaki, Y; Hanaoka, M; Koizumi, T; Uehara, T; Kawakami, S; Hamano, H; Kawa, S; Kubo, K


IgG4-Related Airway Involvement Which Developed in a Patient Receiving Corticosteroid Therapy for Autoimmune Pancreatitis
Intern Med,50(24):3023-3026 2011
Author:Yamamoto, H; Yasuo, M; Nomura, Y; Agatsuma, T; Ushiki, A; Yokoyama, T; Urushihata, K; Hanaoka, M; Koizumi, T; Iwaya, M; Yoshizawa, A; Kawakami, S; Hamano, H; Kawa, S; Kubo, K


A Case of Organizing Pneumonia Induced by Tocilizumab
Intern Med,50(19):2191-2193 2011
Author:Ikegawa, K; Hanaoka, M; Ushiki, A; Yamamoto, H; Kubo, K


Myocardial performance index in subjects susceptible to high-altitude pulmonary edema
Internal Medicine,50:2967-2973 2011
Author:Hanaoka M, Kogashi K, Droma Y, Urushihata K, Kubo K


Carbocisteine protects against emphysema induced by cigarette smoke extract in rats
Chest,139:1101-1108 2011
Author:Hanaoka M, Droma Y, Chen Y, Agatsuma T, Kitaguchi Y, Voelkel NF, Kubo K


Iodine-123 metaiodobenzylguanidine scintigraphic assessment of pulmonary vascular status in patients with chronic obstructive pulmonary disease
RESPIROLOGY,15(8):1215-1219 2010(Nov.)
Author:Koizumi, Tomonobu; Urushihata, Kazuhisa; Hanaoka, Masayuki; Tsushima, Kenji; Fujimoto, Keisaku; Fujii, Tadashige; Kubo, Keishi


Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats
EUROPEAN RESPIRATORY JOURNAL,35(4):904-912 2010(Apr.)
Author:Chen, Y.; Hanaoka, M.; Droma, Y.; Chen, P.; Voelkel, N. F.; Kubo, K.


Clinical characteristics of combined pulmonary fibrosis and emphysema
RESPIROLOGY,15(2):265-271 2010(Feb.)
Author:Kitaguchi, Yoshiaki; Fujimoto, Keisaku; Hanaoka, Masayuki; Kawakami, Satoshi; Honda, Takayuki; Kubo, Keishi


Evaluation of Respiratory Impedance in Asthma and COPD by an Impulse Oscillation System
Intern Med,49(1):23-30 2010
Author:Kanda, Shintarou; Fujimoto, Keisaku; Komatsu, Yoshimichi; Yasuo, Masanori; Hanaoka, Masayuki; Kubo, Keishi


Gradual Progression of Interstitial Pneumonia Induced by Bepridil
Intern Med,48(23):2033-2035 2009
Author:Suzuki, Toshiro; Hanaoka, Masayuki; Yokoyama, Toshiki; Koizumi, Tomonobu; Kubo, Keishi


孤立性肺腫瘤陰影を呈しCA19-9が高値を示した 非結核性抗酸菌症の1例
信州医学雑誌,56(6):365-370 2008
Author:中川佐和子,吾妻俊彦,横山俊樹,牛木淳人,田名部毅,安尾将法,山本洋,花岡正幸,小泉知展,藤本圭作,久保惠嗣,椎名隆之,近藤竜一,吉田和夫,浅野功治,山﨑善隆
Keywords:solitary pulmonary mass shadow,CA19-9,nontuberculous,mycobacterial disease,孤立性肺腫瘤影,非結核性抗酸菌症


長野県中学校集団登山における疾病発生状況
信州医学雑誌,56(3):133-140 2008
Author:花岡正幸,浅川俊,西村良平,川崎洋一郎,漆畑一寿,久保惠嗣
Keywords:acute mountain sickness,group mountain climbing,junior high school,Lake Louise scoring system,questionnaire,急性高山病,集団登山,中学校,レイク・ルイーズスコア,質問票


Pulmonary haemodynamic changes in patients with severe COPD
RESPIROLOGY,13(6):919-922 2008
Author:Hanaoka, M; Ideura, G; Ito, M; Urushihata, K; Koizumi, T; Fujimoto, K; Kubo, K


Adaptation with the to high altitude in sherpas: Association insertion/deletion polymorphism in the angiotensin-converting enzyme gene
WILDERNESS&ENVIRONMENTAL MEDICINE,19(1):22-29 2008
Author:Droma, Y; Hanaoka, M; Basnyat, B; Arjyal, A; Neupane, P; Pandit, A; Sharma, D; Ito, M; Miwa, N; Katsuyama, Y; Ota, M; Kubo, K


えのき栽培従事者に発症した培地が原因と考えられた過敏性肺臓炎の1例
信州医学雑誌,53(2):73-75 2005(Apr.)
Author:竹内崇博,笹林万里,津島健司,漆畑一寿,花岡正幸,小泉知展,藤本圭作,久保惠嗣
Keywords:hypersensitivity pneumonitis, culture medium of enoki mushrooms, 過敏性肺臓炎, えのき培地


高地肺生理学とわが国の高地肺水腫
日本胸部臨床,60:242-253 2001
Author:花岡正幸/久保惠嗣


Hypoxia-induced pulmonary blood redistribution in subjects with a history of high-altitude pulmonary edema
CIRCULATION,101(12):1418-1422 2000
Author:M. Hanaoka/ M. Tanaka/ R. Ge


ARDSとその周辺 高地肺水腫
救急医学,23:981-983 1999
Author:花岡正幸/久保惠嗣


Interferon-alpha elevates pulmonary blood pressure in sheep - the roleof thromboxane cascade
EUROPEAN JOURNAL OF PHARMACOLOGY,370(2):145-151 1999
Author:M. Hanaoka/ K. Kubo, T/ T. Hayano


Effect of post-treatment with granulocyte colony-stimulating factor on endotoxin-induced lung injury in sheep
EXPERIMENTAL LUNG RESEARCH,24(1):15-25 1998
Author:M. Hanaoka/ K. Kubo, T/ T.Miyahara


Association of high-altitude pulmonary edema with the major histocompatibility complex
CIRCULATION,97(12):1124-1128 1998
Author:M. Hanaoka/ K. Kubo, T/ Y. Yamazaki

研究費
科学研究費補助金(研究代表者)
2019 - 2021 , 動物モデルを用いた第3群肺高血圧症の治療戦略の構築 , 基盤研究(B)

教育活動実績

授業等
2002~ , ユニット講義(呼吸器)