信州大学HOMEENGLISH交通・キャンパス案内

研究者総覧研究者総覧

研究者、研究内容などで検索
項目別検索はこちら

小池健一  コイケ ケンイチ

所属部署名医学部 医学科 小児医学電話番号
職名副学長(教育・学生支援担当) 副理事 高等教育研究センター長FAX番号
住所〒390-8621 長野県松本市旭3-1-1メールアドレス
  ホームページURL

更新日:2014/8/19

プロフィール

研究分野
小児血液腫瘍学
現在の研究課題
小児血液腫瘍疾患の診断、治療

造血幹細胞移植

造血幹細胞の制御機構の解析

肥満細胞の増殖分化の解析と新しい抗アレルギー療法の開発

所属学会
所属学会
日本小児科学会
日本臨床血液学会
日本血液学会
日本小児血液学会
日本小児がん学会
日本産婦人科
新生児血液学会
日本小児感染症学会
学歴
出身学校・専攻等(大学院を除く)
1975 , 信州大学 , 医学部 , 卒業

取得学位
医学博士
研究職歴等
研究職歴
2000 - , 信州大学(大学院医学研究科) 助教授
2000 - , 信州大学 助教授
1993 - , 信州大学(医学部) 助教授
1991 - , 信州大学(医学部) 講師
1981 - , 信州大学(医学部) 助手
1993 - 2000 , 信州大学 助教授
1991 - 1993 , 信州大学 講師
1981 - 1991 , 信州大学 助手

研究活動業績

研究業績(著書・
発表論文等)
論文
Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia
LEUKEMIA , 28(7):1545-1548 2014(Jul.)
Author:Matsuda, K; Nakazawa, Y; Iwashita, C; Kurata, T; Hirabayashi, K; Saito, S; Tanaka, M; Yoshikawa, K; Yanagisawa, R; Sakashita, K; Sasaki, S; Honda, T; Koike, K


Cytomegalovirus retinitis during maintenance therapy for T-cell acute lymphoblastic leukemia.
J Pediatr Hematol Oncol. , 35:162-3. 2013
Author:Wakai K, Sano H, Shimada A, Shiozawa Y, Park MJ, Sotomatsu M, Yanagisawa R, Koike K, Kozawa K, Ryo A, Tsukagoshi H, Kimura H, Hayashi Y.


Successful ganciclovir therapy in a patient with human herpesvirus-6 encephalitis after unrelated cord blood transplantation: usefulness of longitudinal measurements of viral load in cerebrospinal fluid.
Infection. , 41:219-23 2013
Author:Hirabayashi K, Nakazawa Y, Katsuyama Y, Yanagisawa T, Saito S, Yoshikawa K, Shigemura T, Sakashita K, Ichikawa M, Koike K.


Recipient seropositivity for adenovirus type 11 (AdV11) is a highly predictive factor for the development of AdV11-induced hemorrhagic cystitis after allogeneic hematopoietic SCT.
Bone Marrow Transplant. , 48:737-9 2013
Author:Nakazawa Y, Saito S, Yanagisawa R, Suzuki T, Ito T, Ishida F, Muramatsu H, Matsumoto K, Kato K, Ishida H, Umeda K, Adachi S, Nakahata T, Koike K.


Replaced platelet concentrates containing a new additive solution, M-sol: safety and efficacy for pediatric patients.
Transfusion. , 53:2053-60. 2013
Author:Yanagisawa R, Shimodaira S, Kojima S, Nakasone N, Ishikawa S, Momose K, Honda T, Yoshikawa K, Saito S, Tanaka M, Nakazawa Y, Sakashita K, Shiohara M, Akino M, Hirayama J, Azuma H, Koike K.


Successful cord blood transplantation after repeated transfusions of unmobilized neutrophils in addition to antifungal treatment in an infant with chronic granulomatous disease complicated by invasive pulmonary aspergillosis. Transfusion.
Transfusion. 2013
Author:Shigemura T, Nakazawa Y, Yoshikawa K, Hirabayashi K, Saito S, Kobayashi N, Sakashita K, Shiohara M, Wada T, Shimodaira S4, Agematsu K and Koike K.


Usefulness of allogeneic hematopoietic stem cell transplantation in first complete remission for pediatric blastic plasmacytoid dendritic cell neoplasm with skin involvement: a case report and review of literature.
Pediatr Blood Cancer, , 60(E):140-2 2013
Author:Sakashita K, Saito S, Yanagisawa R Miyuki Tanaka M, Yoshikawa K, Hirabayashi K, Tsukahara K, Motobayashi M, Nakazawa Y, Koike K.


Neurologically normal development of a patient with severe methionine adenosyltransferase I/III deficiency after continuing dietary methionine restriction.
Gene. , 530:104-8 2013
Author:Hirabayashi K, Shiohara M, Yamada K, Sueki A, Ide Y, Takeuchi K, Hagimoto R, Kinoshita T, Yabuhara A, Mudd SH, Koike K.


Critical illness polyneuropathy and myopathy caused by bacillus cereus sepsis in acute lymphoblastic leukemia.
J Pediatr Hematol Oncol , 34(e):110-3 2012
Author:Hirabayashi K, Shiohara M, Suzuki T, Saito S, Tanaka M, Yanagisawa R, Tsuruta G, Fukuyama T, Hidaka Y, Nakazawa Y, Shimizu T, Sakashita K, Koike K.


Recessive RYR1 mutations in a patient with severe congenital nemaline myopathy with ophthalomoplegia identified through massively parallel sequencing.
Am J Med Genet A. , 158A:772-8 2012
Author:Kondo E, Nishimura T, Kosho T, Inaba Y, Mitsuhashi S, Ishida T, Baba A, Koike K, Nishino I, Nonaka I, Furukawa T, Saito K.


Neurodevelopmental features in 2q23.1 microdeletion syndrome: report of a new patient with intractable seizures and review of literature.
Am J Med Genet A. , 158A(4):861-8 2012
Author:Motobayashi M, Nishimura-Tadaki A, Inaba Y, Kosho T, Miyatake S, Niimi T, Nishimura T, Wakui K, Fukushima Y, Matsumoto N, Koike K.


Long-term haematological improvement after non-intensive or no chemotherapy in juvenile myelomonocytic leukaemia and poor correlation with adult myelodysplasia spliceosome-related mutations.
Br J Haematol. , 157:647-50 2012
Author:Matsuda K, Yoshida N, Miura S, Nakazawa Y, Sakashita K, Hyakuna N, Saito M, Kato F, Ogawa A, Watanabe A, Sotomatsu M, Kobayashi C, Ito T, Ishida F, Manabe A, Kojima S, Koike K.


Genetic evaluation of childhood acute lymphoblastic leukemia in Iraq using FTA cards.
Pediatr Blood Cancer. , 59:461-7. 2012
Author:Al-Kzayer LF, Sakashita K, Matsuda K, Al-Hadad SA, Al-Jadiry MF, Abed WM, Abdulkadhim JM, Al-Shujairi TA, Hasan JG, Al-Abdullah HM, Al-Ani MH, Saber PA, Inoshita T, Kamata M, Koike K.


Food allergy after cord blood transplantation in children.
Br J Haematol. , 158:672-6. 2012
Author:Sakashita K, Nakazawa Y, Yanagisawa R, Tanaka M, Saito S, Yoshikawa K, Hirabayashi K, Kusakari M, Kato S, Hidaka N, Nakayama Y, Shigemura T, Kobayashi N, Kobayashi M, Shiohara M, Koike K.


Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia.
Blood. , 120:1485-8. 2012
Author:Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Mori-Ezaki M, Sato M, Kawaguchi H, Kinoshita A, Sotomatsu M, Hayashi Y, Furukawa-Hibi Y, Yamada K, Hoshino H, Kiyoi H, Yoshida N, Sakaguchi H, Narita A, Wang X, Ismael O, Xu Y, Nishio N, Tanaka M, Hama A, Koike K, Kojima S.


Genetic evaluation of childhood acute lymphoblastic leukemia in Iraq using FTA cards.
Pediatr Blood Cancer. , :1002 2012
Author:Al-Kzayer LF, Sakashita K, Matsuda K, Al-Hadad SA, Al-Jadiry MF, Abed WM, Abdulkadhim JM, Al-Shujairi TA, Hasan JG, Al-Abdullah HM, Al-Ani MH, Saber PA, Inoshita T, Kamata M, Koike K.


Long-term haematological improvement after non-intensive or no chemotherapy in juvenile myelomonocytic leukaemia and poor correlation with adult myelodysplasia spliceosome-related mutations.
Br J Haematol. , 157:647-50 2012
Author:Matsuda K, Yoshida N, Miura S, Nakazawa Y, Sakashita K, Hyakuna N, Saito M, Kato F, Ogawa A, Watanabe A, Sotomatsu M, Kobayashi C, Ito T, Ishida F, Manabe A, Kojima S, Koike K.


Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome
PEDIATRIC RHEUMATOLOGY , 9:15 2011(Jul.)
Author:Shigemura, T; Yamazaki, T; Hara, Y; Ou, JN; Stevens, AM; Ochs, HD; Koike, K; Agematsu, K


Disappearance of minimal residual disease after the early withdrawal of immunosuppressants in a patient with juvenile myelomonocytic leukemia.
Pediatr Blood Cancer. , 56:501-2 2011
Author:Yanagisawa R, Matsuda K, Sakashita K, Nakazawa Y, Tanaka M, Saito S, Yoshikawa K, Kamijo T, Shiohara M, Koike K.


Engraftment syndrome, but not acute graft-versus-host disease, younger age, CYP3A5 or MDR1 polymorphisms, increases tacrolimus clearance in pediatric hematopoietic stem cell transplantation.
Bone Marrow Transplantation , 46:90-97 2011
Author:Yanagisawa R, Katsuyama Y, Shigemura T, Saito S, Tanaka M, Nakazawa Y, Sakashita K, Shiohara M, Koike K.


Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation.
Blood , 117:2887-90 2011
Author:Takagi M, Shinoda K, Piao J, Mitsuiki N, Takagi M, Matsuda K, Muramatsu H, Doisaki S, Nagasawa M, Morio T, Kasahara Y, Koike K, Kojima S, Takao A, Mizutani.


Genetic analysis of TP53 in childhood myelodysplastic syndrome and juvenile myelomonocytic leukemia
Leuk Res , 35:1578-84 2011
Author:Saito S, Matsuda K, Taira C, Sano K, Tanaka-Yanagisawa M, Yanagisawa R, Nakazawa Y, Sakashita K, Shiohara M, Koike K.


Long-term survival after nonintensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of healthy persons with the mutations
BLOOD , 115(26):5429-5431 2010(Jul.)
Author:Matsuda, Kazuyuki; Taira, Chiaki; Sakashita, Kazuo; Saito, Shoji; Tanaka-Yanagisawa, Miyuki; Yanagisawa, Ryu; Nakazawa, Yozo; Shiohara, Masaaki; Fukushima, Keitaro; Oda, Megumi; Honda, Takayuki; Nakahata, Tatsutoshi; Koike, Kenichi


Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia
BRITISH JOURNAL OF HAEMATOLOGY , 148(4):593-599 2010(Feb.)
Author:Matsuda, Kazuyuki; Sakashita, Kazuo; Taira, Chiaki; Tanaka-Yanagisawa, Miyuki; Yanagisawa,Ryu; Shiohara, Masaaki; Kanegane, Hirokazu; Hasegawa, Daiichiro; Kawasaki, Keiichiro; Endo, Mikiya; Yajima, Shuhei; Sasaki, Shinya; Kato, Keisuke; Koike, Kazutoshi; Kikuchi, Akira; Ogawa, Atsushi; Watanabe, Akihiro; Sotomatsu, Manabu; Nonoyama, Shigeaki; Koike, Kenichi


Long-term survival after non-intensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of normal individuals with the mutations.
Blood , 115:5429-31 2010
Author:Matsuda K, Taira C, Sakashita K, et al.


Low toxicity of a conditioning with 8-Gy total body irradiation, fludarabine and cyclophosphamide as preparative regimen for allogeneic hematopoietic stem cell transplantation in pediatric hematological malignancies
PEDIATRIC TRANSPLANTATION , 13(6):737-745 2009(Sep.)
Author:Yanagisawa, Ryu; Nakazawa, Yozo; Sakashita, Kazuo; Tanaka, Miyuki; Shikama, Naoto; Kamijo, Takehiko; Shiohara, Masaaki; Koike, Kenichi


Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia.
Pediatr Res. , 65:334-40 2009
Author:Yoshida N, Yagasaki H, Xu Y, Matsuda K, Yoshimi A, Takahashi Y, Hama A, Nishio N, Muramatsu H, Watanabe N, Matsumoto K, Kato K, Ueyama J, Inada H, Goto H, Yabe M, Kudo K, Mimaya J, Kikuchi A, Manabe A, Koike K


Cryptic insertion into 11q23 of MLLT10 on 10p12 not involved in t(1;15;11;10)(p36;q11;q23;q24) generated MLL/MLLT10 fusion transcript in infant acute biphenotypic leukemia: application of genomic MLL rearrangement to quantification of minimal residual disease.
Cancer Genet Cytogenet , 190:113-20 2009
Author:Matsuda K, Tanaka M, Araki S, Yanagisawa R, Yamauchi K, Koike K.


Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia.
Br J Haematol , 141:567-75 2009
Author:Matsuda K, Sakashita K, Taira C, Tanaka-Yanagisawa M, Yanagisawa R, Shiohara M, Kanegane H, Hasegawa D, Kawasaki K, Endo M, Yajima S, Sasaki S, Kato K, Koike K, Kikuchi A, Ogawa A, Watanabe A, Sotomatsu M, Nonoyama S, Koike K


Acquisition of loss of the wild-type NRAS locus with aggressive disease progression in a patient with juvenile myelomonocytic leukemia and a heterozygous NRAS mutation
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL , 92(11):1576-1578 2007
Author:Matsuda, K; Nakazawa, Y; Sakashita, K; Shiohara, M; Yamauchi, K; Koike, K


Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations
BLOOD , 109(12):5477-5480 2007
Author:Matsuda, K; Shimada, A; Yoshida, N; Ogawa, A; Watanabe, A; Yajima, S; Iizuka, S; Koike, K; Yanai, F; Kawasaki, K; Yanagimachi, M; Kikuchi, A; Ohtsuka, Y; Hidaka, E; Yamauchi, K; Tanaka, M; Yanagisawa, R; Nakazawa, Y; Shiohara, M; Manabe, A; Kojima, S; Koike, K


Chromosomal change during 6-mercaptopurine (6-MP)therapy in juvenile myelomonocytic leukemia: the growth of a 6-MP-refractory clone that already exists at onset
LEUKEMIA , 20(3):485-490 2006
Author:Matsuda, K; Matsuzaki, S; Miki, J; Hidaka, E; Yanagisawa, R; Nakazawa, Y; Sakashita, K; Kamijo, T; Asami, K; Sano, K; Koike, K
Keywords:二相性インスリンアナログ製剤


Dysregulation of histone modification and DNA methylation in acute myeloid leukemia.
CLINICAL IMMUNOLOGY , 115:S171-S172 2005
Author:Ogawa, M; Sakashita, K; Koike, K
Keywords:QOL


【MDSとMPDをめぐる最近の進歩】小児MDS/MPDの臨床的特異性と病態解明の進歩
血液・腫瘍科 , 50:258-264 2005
Author:田中美幸,小池健一


チェルノブイリ原発事故後のベラルーシ共和国に対する医療協力
日本産婦人科・新生児血液学会誌 , 14:68-75 2005
Author:小池健一


Methylation status of the p15 and p16 genes in paediatricmyelodysplastic syndrome and juvenile myelomonocytic leukaemia
Br J Haematol , 128(6):805-812 2005
Author:Hasegawa D, Manabe A, Kubota T, Kawasaki H, Hirose I, Ohtsuka Y, Tsuruta T, Ebihara Y, Goto Y, Zhao XY, Sakashita K, Koike K, Isomura M, Kojima S, Hoshika A, Tsuji K, Nakahata T


Granulocyte-macrophage colony-stimulating factor induces de novo methylation of the p15 CpG island in hematopoietic cells
Cytokine , 31(3):203-212 2005
Author:Zhao XY, Sakashita K, Kamijo T, Hidaka E, Sugane K, Kubota T, Koike K


Development of two cytogenetically abnormal clones from multipotential hematopoietic stem cells in a patient with juvenile myelomonocytic leukemia
Leuk Res , 29(9):1069-1072 2005
Author:Matsuzaki S, Matsuda K, Miki J, Nakazawa Y, Sakashita K, Kamijo T, Hidaka E, Koike K


Regulation of mast cell development
Chem Immunol Allergy , 87:1-21 2005
Author:Shiohara M, Koike K


Viral infections in juvenile myelomonocytic leukemia: Prevalence and clinical implications
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY , 26(10):636-641 2004
Author:Manabe, A; Yoshimasu, T; Ebihara, Y; Yagasaki, H; Wada, M; Ishikawa, K; Hara, J; Koike, K; Moritake, H; Park, YD; Tsuji, K; Nakahata, T


Successful unrelated cord blood transplantation using a reduced-intensity conditioning regimen in a 6-month-old infant with congenital neutropenia complicated by severe pneumonia
Int J Hematol , 80(3):287-290 2004
Author:Nakazawa Y, Sakashita K, Kinoshita M,Saida K, Shigemura T, Yanagisawa R, Shikarna N, Kamijo T, Koike K


Bilineage acute leukemia of T-lymphoid and myeloid lineages
Haematologica , 89(9):1139-1141 2004
Author:Kobayashi N, Matsuda K, Sakashita K, Matsuzaki S, Iwasaki R, Koike K


多施設国際遠隔医療ネットワークを用いたチェルノブイリ原発事故後のベラルーシ共和国に対する医療支援
医学物理 , 23:44-50 2003
Author:小池健一,小宮山 淳,滝沢正臣,中井桂司,村瀬澄夫,神谷さだ子,鎌田 實,オリガ・ビテリエブナ・アレイニコワ,ミハエル・ボガチェンコ


Serum inhibitors for human mast cell growth: possible role of retinol
Allergy , 58(10):1044-1052 2003
Author:Ishida S, Kinoshita T, Sugawara N, Yamashita T, Koike K


STI571 inhibits growth and adhesion of human mast cells in culture
JOURNAL OF LEUKOCYTE BIOLOGY , 74(6):1026-1034 2003
Author:Takeuchi K, Koike K, Kamijo T, Ishida S, Nakazawa Y, Kurokawa Y, Sakashita K, Kinoshita T, Matsuzawa S, Shiohara M, Yamashita T, Nakajima M, Komiyama A


Serologic analysis of three cases of neonatal alloimmune thrombocytopenia associated with HLA antibodies
Transfusion , 43(7):908-917 2003
Author:Saito S, Ota M, Komatsu Y, Ota S, Aoki S, Koike K, Tokunaga I, Tsuno T, Tsuruta G, Kubo T, Fukushima H


IL-9 enhances the growth of human mast cell progenitors under stimulation with stem cell factor
J Immunol , 170(7):3461-3467 2003
Author:Matsuzawa S, Sakashita K, Kinoshita T, Ito S, Yamashita T, Koike K


Allogeneic hematopoietic stem cell transplantation for 27 children with juvenile myelomonocytic leukemia diagnosed based on the criteria of the International JMML Working Group
Leukemia , 16:645-649 2002
Author:Manabe A, Okamura J, Yumura-Yagi K, Akiyama Y, Sako M, Uchiyama H, Kojima S, Koike K, Saito T, Nakahata T


IL-6 enhances IgE-dependent histamine release from human peripheral blood-derived cultured mast cells
Cytokine , 20(5):200-209 2002
Author:Kikuchi T, Ishida S, Kinoshita T, Sakuma S, Sugawara N, Yamashita T, Koike K


Synergism between stem cell factor and granulocyte-macrophage colony-stimulating factor on cell proliferation by induction of cyclins
Cytokine , 19(6):267-275 2002
Author:Kamijo T, Koike K, Nakazawa Y, Takeuchi K, Ishii E, Komiyama A


A possible role for maternal HLA antibody in a case of alloimmune neonatal neutropenia
TRANSFUSION , 41(5):615-620 2001
Author:Hagimoto, R; Koike, K; Sakashita, K; Ishida, T; Nakazawa, Y; Kurokawa, Y; Kamijo, T; Saito, S; Hiraoka, A; Kobayashi, M; Komiyama, A


An increase in circulating mast cell colony-forming cells in asthma. 共著, Mwamtemi HH, Koike K, 他18名 J Immunol. 166:4672-7 (2001).
JOURNAL OF IMMUNOLOGY , 166(7):4672-4677 2001


Dynamic DNA methylation change in the CpG island region of p15 during human myeloid development.共著, Sakashita K, Koike K, 他5名J Clin Invest. 108:1195-204 (2001).
JOURNAL OF CLINICAL INVESTIGATION , 108(8):1195-1204 2001


Quantitative and qualitative differences in thrombopoietin-dependent hematopoietic progenitor development between cord blood and bone marrow
TRANSPLANTATION , 69(8):1645-1654 2000
Author:Mwamtemi, HH; Higuchi, T; Sawai, N; Hidaka, E; Koike, K


Thrombopoietin enhances neutrophil production by bone marrow hematopoietic progenitors with the aidof stem cell factor in congenital neutropenia
JOURNAL OF LEUKOCYTE BIOLOGY , 68(1):137-143 2000
Author:Sawai, N; Koike, K; Mwamtemi, HH; Ito, S; Kurokawa, Y; Sakashita, K; Kinoshita, T; Higuchi, T; Takeuchi, K; Shiohara, M; Kamijo, T; Higuchi, Y; Miyazaki, H; Kato, T; Kobayashi, M; Miyake, M; Yasui, K; Komiyama, A


Retinoic acid is a negative regulator for the differentiation of cord blood-derived human mast cell progenitors
BLOOD , 95(9):2821-2828 2000
Author:Kinoshita, T; Koike, K; Mwamtemi, HH; Ito, S; Ishida, S; Nakazawa, Y; Kurokawa, Y; Sakashita, K; Higuchi, T; Takeuchi, K; Sawai, N; Shiohara, M; Kamijo, T; Kawa, S; Yamashita, T; Komiyama, A


Apoptosis of erythroid precursors under stimulation with thrombopoietin: Contribution to megakaryocytic lineage choice
STEM CELLS , 17(1):45-53 1999
Author:Sawai, N; Koike, K; Ito, S; Kurokawa, Y; Mwamtemi, HH; Kinoshita, T; Sakashita, K; Higuchi, T; Takeuchi, K; Shiohara, M; Ogami, K; Komiyama, A


Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro
BLOOD , 93(6):2057-2066 1999
Author:Shiohara, M; Dawson, MI; Hobbs, PD; Sawai, N; Higuchi, T; Koike, K; Komiyama, A; Koeffler, HP


Chemokine production by human megakaryocytes derived from CD34-positive cord blood cells
CYTOKINE , 11(6):424-434 1999
Author:Takeuchi, K; Higuchi, T; Yamashita, T; Koike, K


A missense mutation in glycoprotein (GP) Ib beta causes Bernard-Soulier syndrome and critical for expression of GPIX.
BLOOD , 94(10):451A-451A 1999
Author:Kurokawa, Y; Ishida, F; Koike, K; Ito, S; Furihata, K; Kitano, K; Kiyosawa, K; Komiyama, A


Neutrophilic cell production by combination of stem cell factor and thrombopoietin from CD34(+) cord blood cells in long-term serum-deprived liquid culture
BLOOD , 93(2):509-518 1999
Author:Sawai, N; Koike, K; Ito, S; Mwamtemi, HH; Kurokawa, Y; Kinoshita, T; Sakashita, K; Higuchi, T; Takeuchi, K; Shiohara, M; Miyazaki, H; Kato, T; Komiyama, A


Thrombopoietin augments stem cell factor-dependent growth of human mast cells from bone marrow multipotential hematopoietic progenitors
BLOOD , 93(11):3703-3712 1999
Author:Sawai, N; Koike, K; Mwamtemi, HH; Kinoshita, T; Kurokawa, Y; Sakashita, K; Higuchi, T; Takeuchi, K; Shiohara, M; Kamijo, T; Ito, S; Kato, T; Miyazaki, H; Yamashita, T; Komiyama, A


Interleukin-6 directly modulates stem cell factor-dependent development of human mast cells derived from CD34(+) cord blood cells
BLOOD , 94(2):496-508 1999
Author:Kinoshita,T; Sawai, N; Hidaka, E; Yamashita, T; Koike, K


Establishment of a GM-CSF-dependent megakaryoblastic cell line with the potential to differentiate into an eosinophilic lineage in response to retinoic acids
BRITISH JOURNAL OF HAEMATOLOGY , 100(2):427-435 1998
Author:Ma, F; Koike, K; Higuchi, T; Kinoshita, T; Takeuchi, K; Mwamtemi, HH; Sawai, N; Kamijo, T; Shiohara, M; Horie, S; Kawa, S; Sasaki, Y; Hidaka, E; Yamagami, O; Yamashita, T; Koike, T; Ishii, E; Komiyama, A


Thrombopoietin enhances the production of myeloid cells, but not megakaryocytes, in juvenile chronic myelogenous leukemia
BLOOD , 91(11):4065-4073 1998
Author:Sawai, N; Koike, K; Higuchi, T; Ogami, K; Oda, M


Cytogenetic clonality analysis in monosomy 7 associated with juvenile myelomonocytic leukemia: clonality in B and NK cells, but not in T cells
LEUKEMIA RESEARCH , 22(10):887-892 1998
Author:Nakazawa, T; Koike, K; Agematsu, K; Itoh, S; Hagimoto, R; Kitazawa, Y; Higuchi, T; Sawai, N; Matsui, H; Komiyama, A


Thrombopoietin enhances the production of myeloid cells, but not megakaryocytes, in juvenile chronic myelogenous leukemia
Blood , 91(11):4065-73 1998
Author:Sawai N, Koike K, 他3名


Proliferative and differentiative potential of thrombopoietin-responsive precursors: Expression of megakaryocytic and erythroid lineages
EXPERIMENTAL HEMATOLOGY , 25(6):463-470 1997
Author:Higuchi, T; Koike, K; Sawai, N; Koike, T


Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro.
BLOOD , 90(10):1468-1468 1997
Author:Shiohara, M; Koike, K; Gombart, AF; Dawson, M; Komiyama, A; Koeffler, HP


Megakaryocytes derived from CD34-positive cord blood cells produce interleukin-8
BRITISH JOURNAL OF HAEMATOLOGY , 99(3):509-516 1997
Author:Higuchi, T; Koike, K; Sawai, N; Mwamtemi, HH; Takeuchi, K; Shiohara, M; Kikuchi, T; Yasui, K; Ito, S; Yamagami, O; Sasaki, Y; Okumura, N; Kato, T; Miyazaki, H; Ikeda, M; Yamada, M; Komiyama, A


Human cultured megakaryocytes produce interleukin-8.
BLOOD , 88(10):226-226 1996
Author:Koike, K; Higuchi, T; Komiyama, A; Kato, T; Miyazaki, H


SYNERGISM OF INTERFERON-GAMMA AND STEM-CELL FACTOR ON THE DEVELOPMENT OF MURINE HEMATOPOIETIC PROGENITORS IN SERUM-FREE CULTURE
BLOOD , 81(6):1435-1441 1993
Author:SHIOHARA, M; KOIKE, K; NAKAHATA, T


STIMULATION OF MOUSE CONNECTIVE TISSUE-TYPE MAST-CELLS BY HEMATOPOIETIC STEM-CELL FACTOR, A LIGAND FOR THE C-KIT RECEPTOR
JOURNAL OF IMMUNOLOGY , 148(11):3446-3453 1992
Author:TAKAGI, M; NAKAHATA, T; KUBO, T; SHIOHARA, M; KOIKE, K; MIYAJIMA, A; ARAI, KI; NISHIKAWA, SI; ZSEBO, KM; KOMIYAMA, A


STEM-CELL FACTOR ENHANCES PROLIFERATION, BUT NOT MATURATION, OF MURINE MEGAKARYOCYTIC PROGENITORS IN SERUM-FREE CULTURE
BLOOD , 80(7):1743-1749 1992
Author:TANAKA, R; KOIKE, K; IMAI,T; SHIOHARA, M; KUBO, T; AMANO, Y; KOMIYAMA, A; NAKAHATA, T


INTERFERON-GAMMA INHIBITS PROLIFERATION, BUT NOT COMMITMENT, OF MURINE GRANULOCYTE-MACROPHAGE PROGENITORS
JOURNAL OF CELLULAR PHYSIOLOGY , 153(3):528-533 1992
Author:KOIKE, K; MA, F; SHIOHARA, M; KUBO, T; TAKAGI, M; AMANO, Y; NAKAHATA, T; KOMIYAMA, A


INTERLEUKIN-6 SUPPORTS HUMAN MEGAKARYOCYTIC PROLIFERATION AND DIFFERENTIATION INVITRO
BLOOD , 78(8):1969-1974 1991
Author:IMAI, T; KOIKE, K; KUBO, T; KIKUCHI, T; AMANO, Y; TAKAGI, M; OKUMURA, N; NAKAHATA, T


Successful bone marrow transplantation in a patient with severe pretransplant pneumonia
Transplantation , 50:326-327 1990
Author:K. Agematsu 他6名

教育活動実績

授業等
2002 , 小児科学
2002 , 腫瘍血液学
2002 , 小児科学
2002 , 腫瘍血液学