信州大学HOMEENGLISH交通・キャンパス案内

研究者総覧研究者総覧

研究者、研究内容などで検索
項目別検索はこちら

石田文宏  イシダ フミヒロ

教員組織学術研究院(保健学系)電話番号
教育組織医学部 保健学科 病因・病態検査学FAX番号
職名教授メールアドレス
住所〒39008621 長野県松本市旭3-1-1ホームページURL

更新日:2019/05/29

プロフィール

研究分野
血液病学・血液検査学
キーワード:リンパ腫 , 大顆粒リンパ球 , 赤芽球癆
現在の研究課題
NK細胞リンパ腫・白血病の病態解明と治療法の開発

血小板減少症の病態解析

顆粒リンパ球増殖機構

赤芽球癆を含めた骨髄不全症候群の分子病態
キーワード:骨髄不全症候群 , T細胞
所属学会
所属学会
日本内科学会
日本血液学会
日本造血細胞移植学会
日本血栓止血学会
日本リンパ網内系学会
American College of Physicians
American Society of Hematology
学歴
出身大学院
1994 , 信州大学 , 医学研究科

出身学校・専攻等(大学院を除く)
1985 , 信州大学 , 医学部
受賞学術賞
1996 , 松医会賞受賞
研究職歴等
研究職歴
2012- , 信州大学医学部保健学系検査技術科学専攻病因・病態検査学領域(教授)

研究活動業績

研究業績(著書・
発表論文等)
著書
血小板膜糖蛋白
文光堂,東京 , Medical Practice編集委員会編:臨床検査ガイド2005~2006 , :pp 590-592 2005
Author:牧島秀樹,石田文宏


血小板 GPIb b遺伝子異常とBernard-Soulier症候群・大血小板
中外医学社,東京 , 高久史麿,溝口秀昭,小宮山 淳,坂田洋一編:Annual Review血液2003 , :pp 146-152 2003
Author:石田文宏


論文
Aggressive NK-Cell Leukemia
FRONTIERS IN PEDIATRICS,6:1-5 2018(Oct.)
Author:Ishida, Fumihiro;


Frequent STAT3 mutations in CD8+ T cells from patients with pure red cell aplasia
BLOOD ADVANCES,2:2704-2712 2018(Oct.)
Author:Toru Kawakami, Nodoka Sekiguchi, Jun Kobayashi, Tatsuya Imi, Kazuyuki Matsuda, Taku Yamane, Sayaka Nishina, Yasushi Senoo, Hitoshi Sakai, Toshiro Ito, Tomonobu Koizumi, Makoto Hirokawa, Shinji Nakao, Hideyuki Nakazawa, Fumihiro Ishida


Breakthrough Candida guilliermondii (Meyerozyma guilliermondii) fungemia after cord blood transplantation for extranodal NK-cell lymphoma with azole prophylaxis
TRANSPLANT INFECTIOUS DISEASE,20(4):- 2018(Aug.)
Author:Nakazawa, Hideyuki; Nishina, Sayaka; Senoo, Yasushi; Sakai, Hitoshi; Ito, Toshiro; Kikuchi, Ken; Ishida, Fumihiro;


Bortezomib maintenance therapy in transplant-ineligible myeloma patients who plateaued after bortezomib-based induction therapy: a multicenter phase II clinical trial
INTERNATIONAL JOURNAL OF HEMATOLOGY,108(1):39-46 2018(Jul.)
Author:Isoda, Atsushi; Murayama, Kayoko; Ito, Shigeki; Kohara, Yoichi; Iino, Masaki; Miyazawa, Yuri; Matsumoto, Morio; Handa, Hiroshi; Imai, Yosuke; Ishiguro, Takuro; Izumita, Wataru; Kitano, Kiyoshi; Hirabayashi, Yukio; Nakazawa, Hideyuki; Ishida, Fumihiro; Mitsumori, Toru; Kirito, Keita; Chou, Takaaki; Murakami, Hirokazu; Kanshinetsu Multiple Myeloma Study;


Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target
NATURE COMMUNICATIONS,9:1-12 2018(Apr.)
Author:Dufva, Olli; Kankainen, Matti; Kelkka, Tiina; Sekiguchi, Nodoka; Awad, Shady Adnan; Eldfors, Samuli; Yadav, Bhagwan; Kuusanmaki, Heikki; Malani, Disha; Andersson, Emma I.; Pietarinen, Paavo; Saikko, Leena; Kovanen, Panu E.; Ojala, Teija; Lee, Dean A.; Loughran, Thomas P., Jr.; Nakazawa, Hideyuki; Suzumiya, Junji; Suzuki, Ritsuro; Ko, Young Hyeh; Kim, Won Seog; Chuang, Shih-Sung; Aittokallio, Tero; Chan, Wing C.; Ohshima, Koichi; Ishida, Fumihiro; Mustjoki, Satu;


Prognostic analysis according to the 2017 ELN risk stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 study
LEUKEMIA RESEARCH,66:20-27 2018(Mar.)
Author:Harada, Yasuhiko; Nagata, Yasunobu; Kihara, Rika; Ishikawa, Yuichi; Asou, Norio; Ohtake, Shigeki; Miyawaki, Shuichi; Sakura, Toru; Ozawa, Yukiyasu; Usui, Noriko; Kanamori, Heiwa; Ito, Yoshikazu; Imai, Kiyotoshi; Suehiro, Youko; Kobayashi, Shinichi; Kitamura, Kunio; Sakaida, Emiko; Onizuka, Makoto; Takeshita, Akihiro; Ishida, Fumihiro; Suzushima, Hitoshi; Ishizawa, Kenichi; Naoe, Tomoki; Matsumura, Itaru; Miyazaki, Yasushi; Ogawa, Seishi; Kiyoi, Hitoshi; Japan Adult Leukemia Study Grp;


Severe Infection of Pseudomonas aeruginosa during Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria
INTERNAL MEDICINE,57(1):127-130 2018
Author:Kawakami, Toru; Nakazawa, Hideyuki; Kurasawa, Yukifumi; Sakai, Hitoshi; Nishina, Sayaka; Senoo, Noriko; Senoo, Yasushi; Ishida, Fumihiro;


大顆粒リンパ球増多症 (特集 リンパ球の増減を正しく評価するために)
臨床検査 = Journal of clinical laboratory medicine,61(8):976-982 2017(Aug.)
Author:石田 文宏;
Keywords:大顆粒リンパ球(LGL)白血病; 細胞傷害性T細胞; NK細胞; STAT;


Oral cyclophosphamide was effective for Coombs-negative autoimmune hemolytic anemia in CD16+CD56-chronic lymphoproliferative disorder of NK-cells
INTERNATIONAL JOURNAL OF HEMATOLOGY,105(6):854-858 2017(Jun.)
Author:Sekiguchi, Nodoka; Nishina, Sayaka; Kawakami, Toru; Sakai, Hitoshi; Senoo, Noriko; Senoo, Yasushi; Ito, Toshiro; Saito, Hiroshi; Nakazawa, Hideyuki; Koizumi, Tomonobu; Ishida, Fumihiro;


A screening method with lymphocyte percentage and proportion of granular lymphocytes in the peripheral blood for large granular lymphocyte (LGL) leukemia
INTERNATIONAL JOURNAL OF HEMATOLOGY,105(1):87-91 2017(Jan.)
Author:Tanahashi, Takahiro; Sekiguchi, Nodoka; Matsuda, Kazuyuki; Matsumoto, Akihiro; Ito, Toshiro; Nakazawa, Hideyuki; Ishida, Fumihiro;


Cell size variations of large granular lymphocyte leukemia: Implication of a small cell subtype of granular lymphocyte leukemia with STAT3 mutations
LEUKEMIA RESEARCH,45:8-13 2016(Jun.)
Author:Tanahashi, Takahiro; Sekiguchi, Nodoka; Matsuda, Kazuyuki; Takezawa, Yuka; Ito, Toshiro; Kobayashi, Hikaru; Ichikawa, Naoaki; Nishina, Sayaka; Senoo, Noriko; Sakai, Hitoshi; Nakazawa, Hideyuki; Ishida, Fumihiro;


A prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment: a multicentre, retrospective analysis
LANCET ONCOLOGY,17(3):389-400 2016(Mar.)
Author:Kim, Seok Jin; Yoon, Dok Hyun; Jaccard, Arnaud; Chng, Wee Joo; Lim, Soon Thye; Hong, Huangming; Park, Yong; Chang, Kian Meng; Maeda, Yoshinobu; Ishida, Fumihiro; Shin, Dong-Yeop; Kim, Jin Seok; Jeong, Seong Hyun; Yang, Deok-Hwan; Jo, Jae-Cheol; Lee, Gyeong-Won; Choi, Chul Won; Lee, Won-Sik; Chen, Tsai-Yun; Kim, Kiyeun; Jung, Sin-Ho; Murayama, Tohru; Oki, Yasuhiro; Advani, Ranjana; d'Amore, Francesco; Schmitz, Norbert; Suh, Cheolwon; Suzuki, Ritsuro; Kwong, Yok Lam; Lin, Tong-Yu; Kim, Won Seog;


Exogenous Magnesium Chloride Reduces the Activated Partial Thromboplastin Times of Lupus Anticoagulant-Positive Patients
PLOS ONE,11(6):- 2016
Author:Tokutake, Takayoshi; Baba, Hisami; Shimada, Yuji; Takeda, Wataru; Sato, Keijiro; Hiroshima, Yuki; Kirihara, Takehiko; Shimizu, Ikuo; Nakazawa, Hideyuki; Kobayashi, Hikaru; Ishida, Fumihiro;


High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia
BLOOD,128(20):2465-2468 2016
Author:Andersson, Emma I.; Tanahashi, Takahiro; Sekiguchi, Nodoka; Gasparini, Vanessa Rebecca; Bortoluzzi, Sabrina; Kawakami, Toru; Matsuda, Kazuyuki; Mitsui, Takeki; Eldfors, Samuli; Bortoluzzi, Stefania; Coppe, Alessandro; Binatti, Andrea; Lagstrom, Sonja; Ellonen, Pekka; Fukushima, Noriyasu; Nishina, Sayaka; Senoo, Noriko; Sakai, Hitoshi; Nakazawa, Hideyuki; Kwong, Yok-Lam; Loughran, Thomas P.; Maciejewski, Jaroslaw P.; Mustjoki, Satu; Ishida, Fumihiro;


NK細胞腫瘍の診断と治療における最近の進歩 (第76回日本血液学会学術集会) -- (Symposium : Advances in the treatment of NK-cell malignancies)
臨床血液,56(6):645-650 2015(Jun.)
Author:石田 文宏;
Keywords:Mature NK cell neoplasm; L-asparaginase; Hematopoietic stem cell transplantation; Epstein-Barr virus;


LGL白血病のSTAT3遺伝子変異と併発する赤芽球癆
血液内科,70(1):93-96 2015(Jan.)
Author:石田 文宏; 関口 和;
Keywords:LGL leukemia; cytotoxic T cell; NK cell; STAT3; pure red cell aplasia;


NK細胞腫瘍の診断と治療における最近の進歩
臨床血液,56(6):645-650 2015
Author:石田 文宏;
Abstract:アグレッシブNK細胞白血病(ANKL)は成熟NK細胞の白血病で,生存期間中央値が3か月以内と予後不良である。東アジアに多く,8割以上がEBウイルスと関連する。最近実施した34例のANKL07研究では年齢中央値40歳で2相性分布を示した。ANKLの細胞はLGL様から高度異型まで多彩であり,また,三分の一の例では末梢血・骨髄の腫瘍細胞が20%未満であり,診断に留意する必要がある。臨床所見として発熱,肝障害,血球貪食症候群と進行性の経過を認めた。一部の症例ではL-アスパラギナーゼを含む化学療法と同種造血幹細胞移植(HSCT)が有効で治癒可能性が示唆された。節外性NK/T細胞リンパ腫,鼻型(ENKL)に対するHSCTは臨床病期II期以上の症例で完全奏効時に施行された場合には生存期間の延長や治癒につながる可能性があるが,至適な幹細胞ソース,実施時期,前処置等今後更に検討する必要がある。
Keywords:Mature NK cell neoplasm; L-asparaginase; Hematopoietic stem cell transplantation; Epstein-Barr virus;


EBV核酸増幅検査用第一次国際標準品(1st WHO International Standard)に基づく二次標準物質を用いた末梢血中Epstein-Barr virus(EBV)DNA量の評価
医学検査,64(1):48-53 2015
Author:岩下 千奈美; 末木 茜; 松田 和之; 井出 裕一郎; 菅野 光俊; 石田 文宏; 本田 孝行;
Abstract:Epstein-Barr virus(EBV)DNA定量検査は,EBV感染症および関連疾患において疾患の発見や予防のために重要な検査である。EBV DNA量の定量には,標準物質を用いたReal-time PCR法が用いられているが,使用される標準物質は各施設さまざまであり,施設間で定量値を比較できないという問題がある。本研究では,EBV DNA定量検査の第一次国際標準品1st WHO International Standardを用いて,二次標準物質を作製した。また,過去に測定したEBV DNA定量値を,二次標準物質に基づく定量値に換算するための変換係数を求めた。EBV関連造血幹細胞移植後リンパ球増殖性疾患(post-transplant lymphoproliferative disorder: PTLD)疑い症例及びEBV関連血球貪食性リンパ組織球症(EBV-related hemophagocytic lymphohistiocytosis: EBV-HLH)症例について,新規検体は二次標準物質を,過去測定済み検体は換算係数を用いて末梢血中EBV DNA定量値を求めた。それぞれ8.74 × 102~1.51 × 104 IU/μg DNA,1.58 × 104~1.33 × 106 IU/μg DNAであった。多施設で利用可能な二次標準物質が普及することで,EBV関連疾患毎の診断基準となるEBV DNA定量値が設定できると考えられる。
Keywords:EBウイルス; リアルタイムPCR; 第一次国際標準品; 移植後リンパ球増殖性疾患; EBV関連血球貪食性リンパ組織球症;


Prognostic significance of pleural or pericardial effusion and the implication of optimal treatment in primary mediastinal large B-cell lymphoma: a multicenter retrospective study in Japan
HAEMATOLOGICA,99(12):1817-1825 2014(Dec.)
Author:Aoki, Tomohiro; Izutsu, Koji; Suzuki, Ritsuro; Nakaseko, Chiaki; Arima, Hiroshi; Shimada, Kazuyuki; Tomita, Akihiro; Sasaki, Makoto; Takizawa, Jun; Mitani, Kinuko; Igarashi, Tadahiko; Maeda, Yoshinobu; Fukuhara, Noriko; Ishida, Fumihiro; Niitsu, Nozomi; Ohmachi, Ken; Takasaki, Hirotaka; Nakamura, Naoya; Kinoshita, Tomohiro; Nakamura, Shigeo; Ogura, Michinori;


STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia
CANCER SCIENCE,105(3):342-346 2014(Mar.)
Author:Ishida, F; Matsuda, K; Sekiguchi, N; Makishima, H; Taira, C; Momose, K; Nishina, S; Senoo, N; Sakai, H; Ito, T; Kwong, YL


アグレッシブNK細胞白血病の臨床病態と治療
血液内科,68(1):124-128 2014(Jan.)
Author:石田 文宏;
Keywords:natural killer cell; large granular lymphocyte; Epstein-Barr virus; L-asparaginase; allogeneic hematopoietic cell transplantation;


Screening Tests Using Serum Tissue Transglutaminase IgA May Facilitate the Identification of Undiagnosed Celiac Disease among Japanese Population
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES,11(8):819-823 2014
Author:Nakazawa, Hideyuki; Makishima, Hideki; Ito, Toshiro; Ota, Hiroyoshi; Momose, Kayoko; Sekiguchi, Nodoka; Yoshizawa, Kaname; Akamatsu, Taiji; Ishida, Fumihiro;


Large vessel vasculitis developed early after allogeneic bone marrow transplant for acute erythroid leukemia
LEUKEMIA & LYMPHOMA,54(12):2748-2749 2013(Dec.)
Author:Kawakami, Toru; Ito, Toshiro; Sakai, Hitoshi; Sekiguchi, Nodoka; Nakazawa, Hideyuki; Senoo, Noriko; Nishina, Sayaka; Ishida, Fumihiro;


CD56 expression is an independent prognostic factor for relapse in acute myeloid leukemia with t(8;21)
LEUKEMIA RESEARCH,37(9):1021-1026 2013(Sep.)
Author:Iriyama, Noriyoshi; Hatta, Yoshihiro; Takeuchi, Jin; Ogawa, Yoshiaki; Ohtake, Shigeki; Sakura, Toru; Mitani, Kinuko; Ishida, Fumihiro; Takahashi, Masatomo; Maeda, Tomoya; Izumi, Tohru; Sakamaki, Hisashi; Miyawaki, Shuichi; Honda, Sumihisa; Miyazaki, Yasushi; Taki, Tomohiko; Taniwaki, Masafumi; Naoe, Tomoki;


Liver Dysfunction and Thrombocytopenia Diagnosed as Intravascular Large B-cell Lymphoma Using a Timely and Accurate Transjugular Liver Biopsy
INTERNAL MEDICINE,52(17):1903-1908 2013
Author:Sekiguchi, N; Joshita, S; Yoshida, T; Kurozumi, M; Sano, K; Nakagawa, M; Ito, T; Matsushita, T; Komatsu, D; Komatsu, M; Ito, T; Umemura, T; Ikeda, S; Kadoya, M; Ishida, F; Tanaka, E


Splicesome-related gene mutations in myelodysplastic syndrome can be used as stable markers for monitoring minimal residual disease during follow-up
Leukemia Res 2012
Author:Matsuda K, Ishida F, Ito T, Nakazawa H, Miura S, Taira C, Sueki A, Kobayashi Y, Honda T


Aggressive NK-cell leukemia: Therapeutic potentialsof L-asparaginase and allogeneic hematopoietic stem cell transplantation.
Cancer Science,103(6):1079-83 2012
Author:Ishida, F, Ko, Y H, Kim, W S, Suzumiya J, Isobe Y, Oshimi K, Nakamura S, Suzuki R


Donor lymphocyte infusion for extranodal NK/T cell lymphoma, nasal type, relapsed after allogeneic hematopoietic stem cell transplantation
Bone Marrow Transplantation.,46:1270-71 2011
Author:Ito T, Makishima H, Nakazawa H, Senoo Y, Senoo N, Ishida F.


Phase II study of SMILE chemotherapy for newly-diagnosed stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type: the NK-cell Tumor Study Group (NKTSG) study.
J Clin Oncol,29:4410-4416 2011
Author:Yamaguchi M, Kwong YL, Kim, WS, Maeda Y, Hashimoto C, Suh C, Izutu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R Nakamura S, Oshimi K, Suzuki R


Quantitative monitoring of single nucleotidemutations by allele-specific quantitative PCR can be used for the assessment of minimal residual disease in patients with hematological malignancies throughout their clinical cours
Clinica Chimica Acta,412:53-8 2011
Author:Taira C, Matsuda K, Kamijyo Y, Sakashita K, Ishida F, Kumagai T, Yamauchi K, Okumura N, Honda T


A C-terminal amino acid substitution in the gamma-chain caused by a novel heterozygous frameshift mutation (Fibrinogen Matsumoto VII) results in hypofibrinogenaemia
THROMBOSIS AND HAEMOSTASIS,104(2):213-223 2010(Aug.)
Author:Fujihara, Noriko; Haneishi, Ayumi; Yamauchi, Kazuyoshi; Terasawa, Fumiko; Ito, Toshiro; Ishida, Fumihiro; Okumura, Nobuo


Late relapse of extranodal natural killer/T cell lymphoma, nasal type, after more than ten years
LEUKEMIA&LYMPHOMA,51(1):171-173 2010(Jan.)
Author:Ishida, Fumihiro; Nishina, Sayaka; Asano, Naoko; Sasaki, Shigeru; Sekiguchi, Nodoka; Nakazawa, Hideyuki; Ito, Toshiro; Shikama, Naoto


The diagnosis and management of natural killer cell malignancies.
Expert Review of Hematology,3:593-602 2010
Author:Ishida F, Kwong YL


Spontaneous regression of the inhibitor against the coagulation factor XIII A subunit in acquired factor XIII deficiency
Thromb and Haemost,104:1284-5 2010
Author:Ishida F. Okubo K, Ito T, Okumura N, Souri M, Ichinose A


Age-ralated Epstein-Barr virus(EBV) associated B-cell lymphoproliferative disorders:comparison with EBV-positive classic Hodgkin lymphoma in elderly patients
BLOOD,113:2629-2636 2009
Author:Asano N, Yamamoto K, Tamaru J, Oyama T, Ishida F, Oshima K, Yoshino T, Nakumara N, Mori S, Yoshie O,Shimoyama Y, Morishima Y, Kinoshita T, Nakamura S


Promising approach for aggressive NK cell leukaemia with allogeneic haematopoietic cell transplantation
Eur J Haemat,81:107-111 2008
Author:Ito T, Makishima H, Nakazawa H, Kobayashi H, Shimodaira S, Nakazawa Y, Kitano K, Matsuda K, Hidaka E,  Ishida F


Zygomycosis presenting as acute myocardial infarction during hematological malignancies
INTERNAL MEDICINE,47(9):839-842 2008
Author:Joshita, Satoru; Kitano, Kiyoshi; Nagaya, Tadanobu; Kamijo, Atsushi; Nakazawa, Koh; Ishida, Fumihiro


Chemokine system and tissue infiltration in aggressive NK-cell leukemia.
Leukemia Res,31:1245-1253 2007
Author:Makishima H, Ito T, Momose K, Nakazawa H, Shimodaira S, Kamijo Y, Nakazawa Y, Ichikawa N, Ueno M, Kobayashi H, Kitano K, Saito H, Kiyosawa K, Ishida F.


Prognostic significance of T-cell or cytotoxic molecules phenotype in classical Hodgkin’s lymphoma: a clinicopathologic study
J Clin Oncol,24:2646-2633 2006
Author:Asano N, Oshiro A, Matsuo K, Kagami Y, Ishida F, Suzuki R, Kinoshita T, Shimoyama Y, Tamaru J, Yoshino T, Kitamura K, Fukutani H, Morishima Y, Nakamura S.


Intestinal diffuse large B cell lymphoma associated with celiac disease -a Japanesecase
Int J Hematol,83(1):63-65 2006
Author:Makishima H, Ito T, Kodama R, Asano N, Nakazawa H, Hirabayashi K, Nakamura S, Ota M, Akamatsu T, Kiyosawa K, Ishida F.


Thrombotic thrombocytopenic purpura associated with pegylated-interferon alpha-2a by an ADAMTS13 inhibitor in a patient with chronic hepatitis C
Haematologica,91:ECR34 2006
Author:Kitano K, Gibo Y, Kamijo A, Furuta K, Oguchi S, Joshita S, Takahashi Y, Ishida F, Matsumoto M, Uemura M, Fujimura Y


A case of acute myelogenous leukemia with MLL-AF10 fusion caused by insertion of 5’ MLL into 10p12, with concurrent 3’ MLL deletion
Cancer Genet Cytogenet,171(1):24-30 2006
Author:Matsuda K, Hidaka E, Ishida F, Yamauchia K, Makishima H, Ito T, Suzuki T, Imagawa E, Sano K, Katsuyama T, Ota H


Adenovirus fulminant hepatic failure after unrelated allogeneic stem cell transplantation for acute lymphoblastic leukemia
Internal Med,4:975-980 2006
Author:Nakazawa H, Ito T, Makishima H, Misawa N, Okiyama W, Uehara T, Hidaka E, Kiyosawa K, Ishida F


Significance of chemokine receptor expression in aggressive NK cell leukemia
Leukemia,19(7):1169-1174 2005
Author:Makishima H, Ito T, Asano N, Nakazawa H, Shimodaira S, Kamijo Y, Nakazawa Y, Suzuki T, Kobayashi H, Kiyosawa K, Ishida F


Clinicopathologic and prognostic significance of cytotoxic molecule expression in nodal peripheral T-cell lymphoma, unspecified
Am J Surg Pathol,29(10):1284-1293 2005
Author:Asano N, Suzuki R, Kagami Y, Ishida F, Kitamura K, Fukutani H, Morishima Y, Takeuchi K,Nakamura S


Ribavirin-induced pure red-cell aplasia during treatment of chronic hepatitis C
N Engl J Med,350(12):1264-1265 2004
Author:Tanaka .N, Ishida F, Tanaka E


DNA microarray analysis of natural kller cell-type lymphoproliferative disease of granular lymphocytes with purified CD3-CD56+ fractions
Leukemia,18(3):556-565 2004
Author:Choi YL, Makishima H, Ohashi J, Yamashita Y, Ohki R, Koinuma K, Ota J, Isobe Y, Ishida F, Oshimi K, Mano H


抗血小板自己抗体測定法 (第2世代の方法と第3世代の方法)
日本臨床,61:564-568 2003
Author:石田文宏;


Idiopathic myelofibrosis with refractory massive ascites
Intern Med,42(6):525-528 2003
Author:Yotsumoto M, Ishida F, Ito T, Ueno M, Kitano K, Kiyosawa K


Lymphoproliferative disease of granular lymphocytes with T-cell receptor gamma delta-positive phenotype: restricted usage of T-cell receptor gamma and delta subunit genes
Eur J Haematol,70(4):212-218 2003
Author:Makishima H, Ishida F, Saito H, Ichikawa N, Ozaki Y, Ito S, Ota M, Katsuyama Y, Kiyosawa K


Human factor VII deficiency caused by S339C mutation located adjacent to the specificity pocket of the catalytic domain
Clin Lab Haematol,24(4):233-238 2002
Author:Takamiya O, Seta M, Tanaka K, Ishida F


DNA microarray analysis of T cell-type lymphoproliferative disease of granular lymphocytes
Br J Haematol,118(2):462-469 2002
Author:Makishima H, Ishida F, Ito T, Kitano K, Ueno S, Ohmine K, Yamashita Y, Ota J, Ota M, Yamauchi K, Mano H


t (8;21;14) (q22;q22;q24) is a novel variant of t (8;21) with chimeric transcripts of AML1-ETO in acute myelogenous leukemia
Cancer Genet Cytogenet,132(2):133-135 2002
Author:Ishida F, Ueno M, Tanaka H, Makishima H, Suzawa K, Hosaka S, Hidaka E, Ishikawa M, YamauchiK, Kitano K, Kiyosawa K


Fibrinogen Matsumoto V: a variant with a alpha 19 Arg ->Gly (AGG ->GGG) - Comparison between fibrin polymerization stimulated by thrombin or reptilase and fibrin monomer polymerization
THROMBOSIS AND HAEMOSTASIS,85(1):108-113 2001
Author:Tanaka, H; Terasawa, F; Ito, T; Tokunaga, S; Ishida, F; Kitano, K; Kiyosawa, K; Okumura, N


Abnormal proliferation of CD4(-) CD8(+) gamma delta(+) T cells with chromosome 6 anomaly: Role of fas ligand expression in spontaneous regression of the cells
AMERICAN JOURNAL OF HEMATOLOGY,60(4):305-308 1999
Author:Ichikawa, N; Kitano, K; Ito, T; Nakazawa, T; Shimodaira, S; Ishida, F; Kiyosawa, K


Fibrinogen Matsumoto III: a variant with gamma 275 Arg ->Cys (CGC ->TGC) - Comparison of fibrin polymerization properties with those of Matsumoto I (gamma 364 Asp ->His) and Matsumoto II (gamma 308 Asn ->Lys)
THROMBOSIS AND HAEMOSTASIS,81(5):763-766 1999
Author:Terasawa, F; Okumura, N; Higuchi, Y; Ishikawa, S; Tozuka, M; Ishida, F; Kitano, K; Katsuyama, T


Hairy cell leukemia with translocation (11;20)(q13;q11) and overexpression of cyclin D1
LEUKEMIA RESEARCH,23(8):763-765 1999
Author:Ishida, F; Kitano, K; Ichikawa, N; Ito, T; Kohara, Y; Taniguchi, T; Motokura, T; Kiyosawa, K


Elliptocytosis in myelodysplastic syndrome associated with translocation (1;5)(p10;q10) and deletion of 20q
Cancer Genet Cytogenet,108(2):162-165 1999
Author:Ishida, F; Shimodaira, S; Kobayashi, H; Saito, H; Kako, M; Kanzaki, A; Yawata, Y; Kitano, K; Kiyosawa, K


フローサイトメトリーによるBtk蛋白欠損にて診断し得た伴性劣性無ガンマグロブリン血症孤発例 (本邦最高齢症例)
臨床血液,39(1):44-47 1998(Jan. 30)
Author:石田 文宏; 小林 光; 斉藤 博; 二谷 武; 宮脇 利男; 清澤 研道;
Abstract:症例は39歳,男性。幼児期より気道の易感染傾向があり,4歳時ポリオ生ワクチン接種後左上下肢の不全麻痺となっている。22歳時IgG, IgA, IgMの著減,抗原刺激に対する抗体反応の欠如を認めlate onset hypo-γ-globulinemiaでvariable immunodeficiencyと診断された(袖山ほか,日内会誌71: 84∼90, 1982)。その後γ-グロブリン補充療法を受けていたが数度の上気道感染,肺炎で入院している。今回再検討し末梢血中のB細胞が1%以下と減少し,フローサイトメトリーで単球上のBruton型チロシンキナーゼ欠損が証明され伴性劣性無ガンマグロブリン血症(XLA)孤発例と診断した。母親は保因者であった。本例はわれわれの知る限り,XLAの本邦最高齢である。
Keywords:X-linked agammaglobulinemia; Bruton-type tyrosine kinase; flow cytometry;


Cold agglutinin disease by autoanti-i blood type antibody associated with B cell chronic lymphocytic leukemia
INTERNATIONAL JOURNAL OF HEMATOLOGY,67(1):69-73 1998
Author:Ishida, F; Saito, H; Kitano, K; Kiyosawa, K


Associations between polymorphism of platelet membrane glycoprotein Ib alpha, plasma von Willebrand factor antigen and coronary artery disease.
BLOOD,92(10):191A-191A 1998
Author:Ito, T; Ishida, F; Shimodaira, S; Takei, M; Kitano, K; Kiyosawa, K


東アジアにおけるAPCレジスタンス測定の意義
臨床血液 = The Japanese Journal of Clinical Hematology,38(4):316-318 1997(Apr. 30)
Author:石田 文宏; 高宮 脩;
Keywords:APC resistance; Factor V; easten Asia;


Resistance to activated protein C and Arg 506 Gln factor V mutation are uncommon in eastern Asian populations
ACTA HAEMATOLOGICA,98(1):22-25 1997
Author:Kodaira, H; Ishida, F; Shimodaira, S; Takamiya, O; Furihata, K; Kitano, K


Eosinophilia associated with clonal T-cell proliferation
LEUKEMIA&LYMPHOMA,27(3-4):335-342 1997
Author:Kitano, K; Ichikawa, N; Shimodaira, S; Ito, T; Ishida, F; Kiyosawa, K


Elevated IgG4 levels in a case with multicentric Castleman's disease
BRITISH JOURNAL OF HAEMATOLOGY,99(4):981-982 1997
Author:Ishida, F; Kitano, K; Kobayashi, H; Saito, H; Kiyosawa, K


Eosinophilia associated with proliferation of CD3(+)4(-)8(-) alpha beta(+) T cells with chromosome 16 anomalies
BRITISH JOURNAL OF HAEMATOLOGY,92(2):315-317 1996
Author:Kitano, K; Ichikawa, N; Mahbub, B; Ueno, M; Ito, T; Shimodaira, S; Kodaira, H; Ishida, F; Kobayashi, H; Saito, H; Okubo, Y; Enokihara, H; Kiyosawa, K


Serum thrombopoietin (c-mpl ligand) levels in patients with liver cirrhosis
BRITISH JOURNAL OF HAEMATOLOGY,93:1033-1033 1996
Author:Kitano, K; Shimodaira, S; Ishida, F; Ichikawa, N; Kodaira, H; Ito, T; Tahara, T; Kato, T; Kiyosawa, K


Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anemia and idiopathic thrombocytopenic purpura.
EXPERIMENTAL HEMATOLOGY,24(9):428-428 1996
Author:Ichikawa, N; Ishida, F; Shimodaira, S; Ito, T; Tahara, T; Kato, T; Kitano, K


Serum thrombopoietin (c-Mpl ligand) levels in patients with liver cirrhosis
THROMBOSIS AND HAEMOSTASIS,76(4):545-548 1996
Author:Shimodaira, S; Ishida, F; Ichikawa, N; Tahara, T; Kato, T; Kodaira, H; Ito, T; Tanaka, E; Sodeyama, T; Kiyosawa, K; Kitano, K


The largest isoform of platelet membrane glycoprotein Ib?lpha is commonly distributed in eastern Asian populations
Thromb Haemost,76:245-247 1996
Author:Ishida F/ Furihata K


Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenic purpura
Thromb Haemost,76(2):156-160 1996
Author:Ichikawa N/ Ishida F


Serum thrombopoietin(C-Mpl ligand) levels in patients with liver cirrhosis
Thromb Haemost,76:545-548 1996
Author:Shimodaira S/ Ishida F


血小板膜糖蛋白 (GP) Ibαの多型
日本血栓止血学会誌 = The Journal of Japanese Society on Thrombosis and Hemostasis,6(6):442-452 1995(Dec. 01)
Author:石田 文宏; 降旗 謙一;
Keywords:glycoprotein Ibα; polymorphism; HPA-2; tandem repeat; linkage disequilibrium;


THE DETECTION OF CLONAL PROLIFERATION IN GRANULAR LYMPHOCYTE-PROLIFERATIVE DISORDERS OF NATURAL-KILLER-CELL LINEAGE
BRITISH JOURNAL OF HAEMATOLOGY,90(3):578-584 1995
Author:SHIMODAIRA, S; ISHIDA, F; KOBAYASHI, H; MAHBUB, B; KAWAHA, K; KITANO, K


THE LARGEST VARIANT OF PLATELET GLYCOPROTEIN IB-ALPHA HAS 4 TANDEM REPEATS OF 13 AMINO-ACIDS IN THE MACROGLYCOPEPTIDE REGION AND A GENETIC-LINKAGE WITH METHIONINE
BLOOD,86(4):1356-1360 1995
Author:ISHIDA, F; FURIHATA, K; ISHIDA, K; YAN, J; KITANO, K; KIYOSAWA, K; FURUTA, S


APC-RESISTANCE AND MNL-I GENOTYPE (GLN-506) OF COAGULATION-FACTOR-V ARE RARE IN JAPANESE POPULATION
THROMBOSIS AND HAEMOSTASIS,74(3):996-996 1995
Author:TAKAMIYA, O; ISHIDA, F; KODAIRA, H; KITANO, K


Arg 506 Gln factor V mutation is uncommon in eastern Asian populations.
BLOOD,86(10):3658-3658 1995
Author:Kodaira, H; Ishida, F; Ito, T; Ichikawa, N; Shimofaira, S; Takamiya, O; Furihata, K; Kiyosawa, K; Kitano, K


TRANSFUSION-ASSOCIATED GRAFT-VERSUS-HOST DISEASE IN AN IMMUNOCOMPETENT PATIENT FOLLOWING ACCIDENTAL INJURY
AMERICAN JOURNAL OF HEMATOLOGY,43(1):51-53 1993
Author:KOBAYASHI, H; KITANO, K; KISHI, E; HARA, K; ISHIDA, F; SAITO, H; OTA, M; FURUTA, S


EOSINOPHILIA IN MYELODYSPLASTIC SYNDROME WITH A (12 21)(Q23 Q22) TRANSLOCATION
CANCER GENETICS AND CYTOGENETICS,68(2):95-98 1993
Author:KOBAYASHI, H; KITANO, K; SHIMODAIRA, S; ISHIDA, F; SAITO, H; SONOYAMA, M; ENOKIHARA, H; FURUTA, S


APLASTIC-ANEMIA AND IDIOPATHIC THROMBOCYTOPENIC PURPURA WITH ANTIBODY TO PLATELET GLYCOPROTEIN IIB/IIIA FOLLOWING RESECTION OF MALIGNANT THYMOMA
ACTA HAEMATOLOGICA,90(1):42-45 1993
Author:KOBAYASHI, H; KITANO, K; ISHIDA, F; SAITO, H; MIYABAYASHI, H; YONEZAWA, T; INADA, H; SUZUKI, A; FURUTA, S


GENETIC AND STRUCTURAL CHARACTERIZATION OF AN AMINO-ACID DIMORPHISM IN GLYCOPROTEIN IB-ALPHA INVOLVED IN PLATELET TRANSFUSION REFRACTORINESS
BLOOD,79(11):3086-3090 1992
Author:MURATA, M; FURIHATA, K; ISHIDA, F; RUSSELL, SR; WARE, J; RUGGERI, ZM


HUMAN PLATELET-SPECIFIC ANTIGEN, SIBA, IS ASSOCIATED WITH A STRUCTURAL POLYMORPHISM OF GLYCOPROTEIN IB-ALPHA
THROMBOSIS AND HAEMOSTASIS,65(6):796-796 1991
Author:ISHIDA, F; SAJI, H; MARUYA, E; FURUTA, S; FURIHATA, K


HUMAN PLATELET-SPECIFIC ANTIGEN, SIB(A), IS ASSOCIATED WITH THE MOLECULAR-WEIGHT POLYMORPHISM OF GLYCOPROTEIN-IB-ALPHA
BLOOD,78(7):1722-1729 1991
Author:ISHIDA, F; SAJI, H; MARUYA, E; FURIHATA, K


Modified antigen‐capture ELISAによる血小板同種抗原Br`a´/Br`b´の検出
日本輸血学会雑誌,36(6):713-716 1990
Author:石田 文宏; 緒方 洪之; 古田 精市; 降旗 謙一;
Abstract:A platelet alloantigen system, Bra/Brb, is defined recently and is implicated in several cases of neonatal alloimmune thrombocytopenic purpura (NATP) in Europe. Since each platelet has only 1, 000-2, 000 molecules of BraBrb antigens, it is very hard to phenotype platelets by methods in which whole platelets are used as antigens. In this study, we employed modified antigen-capture ELISA (MACE) to phenotype platelets for Bra/Brb. Platelets were easily phenotyped qualitatively and semiquantitatively by MACE in which a murine monoclonal anti-glycoprotein (GP) IIa (4B4; CD29) was used to capture GP Ia-IIa complex. Phenotypic frequencies of Bra and Brb among 67 Japanese were 11.7% and over 98.3%, respectively. Their frequencies among Japanese were significantly differed from those among Caucasians and chilean Indians. Bra/Brb antigen system would be responsible for some cases of NATP and platelet transfusion refractoriness in Japan. MACE would be extremely useful to identify Bra/Brb incompatibility in those cases.


IL-2添加による染色体分析で47XY, +8の異常を認めたnatural killer細胞型granular lymphocyte leukemia
臨床血液,31(10):1711-1715 1990
Author:石田 文宏; 斉藤 博; 降旗 謙一; 古田 精市; 園山 政行; 押味 和夫;
Abstract:A 28-year-old male was admitted to our hospital because of hepatosplenomegaly and granular lymphocytosis. His peripheral leukocyte count was 3,000/μl with 43% of granular lymphocytes (GL). These GLs were immunologically phenotyped as CD2+CD3-CD4-CD8-CD16+CD56+HLA-DR+ and were found that TcR genes coding beta and gamma chains were not rearranged. Chromosomal analysis of his GLs stimulated with IL-2 showed 47 XY, +8. This patient was diagnosed as a granular lymphocyte leukemia of natural killer cell type. Blood chemistry showed elevation of serum GOT, GPT and LDH values. The fever persisted until administration of prednisolone was initiated. But 40 days after, high fever appeared again and the liver and spleen were extremely enlarged. Combined chemotherapy was then started but resulted in no effects. He died of hepatic failure on the 77th day from admission. 47 XY, +8, that has been reported in acute non-lymphocytic leukemia and myelodysplastic syndrome, may be related to the pathogenesis in some cases of granular lymphocyte leukemia.
Keywords:granular lymphocyte leukemia; natural killer cell; 47 XY; +8;


A Missense Mutation (Tyr88 to Cys) in the Platelet Membrane Glycoprotein Ib?eta gene affects the expression of GPIb/IX complex expression
Thromb Haemost
Author:Kurokawa Y/ Ishida F

研究費
科学研究費補助金(研究代表者)
2015 - , アグレッシブNK細胞白血病の発症関連遺伝子異常の同定と新規治療法開発

教育活動実績

授業等
2018 , ユニット講義 血液
2018 , 血液検査学
2018 , 血液検査学実習II
2018 , 血液検査学実習I
2018 , 後期 , 分子血液学

社会活動実績

社会活動等
出前講座
血液検査ってなにするの?

講演会
第37回グループ・ネクサス・ジャパン リンパ腫医療セミナー , T細胞およびNK細胞リンパ腫の病態と治療