α1,4-linked N-acetylglucosamine suppresses gastric cancer development by inhibiting Mucin-1-mediated signaling. Cancer Sci.,in press 2022 Author:Fujii C (corresponding author), Harumiya S, Sato Y, Kawakubo M, Matoba H, Nakayama J.
MUC6 expression is a preferable prognostic marker for invasive mucinous adenocarcinoma of the lung. Histochem. Cell Biol.,157:671-684 2022 Author:Yamanoi K, Fujii C (co-first author), Yuzuriha H, Kumazawa M, Shimoda M, Emoto K, Asamura H, Nakayama J.
Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy. Cancer Sci.,113:576-586 2022 Author:Yuki A, Fujii C (co-first author, corresponding author), Yamanoi K, Matoba H, Harumiya S, Kawakubo M, Nakayama J.
Cholestenone functions as an antibiotic against Helicobacter pylori by inhibiting biosynthesis of the cell wall component CGL Proc. Natl. Acad. Sci. USA,118:e2016469118 2021 Author:Kobayashi J, Kawakubo M, Fujii C, Arisaka N, Miyashita M, Sato Y, Komura H, Matoba H, and Nakayama J
Cecal tumorigenesis in Aryl hydrocarbon receptor-deficient mice depends on cecum-specific mitogen-activated protein kinase pathway activation and inflammation Am. J. Pathol.,190:253-268 2020 Author:Matoba H, Takamoto M*, Fujii C*,Kawakubo M, Kasuga E, Matsumura T, Natori T,Misawa K, Taniguchi S, and Nakayama J (*: Corresponding author)
Analysis of A4gnt knockout mice reveals an essential role for gastric sulfomucins in preventing gastritis cystica profunda J. Histtochem. & Cytochem.,67:759-770 2019 Author:Kawakubo M, Komura H, Goso Y, Okumura M, Sato Y, Fujii C, Miyashita M, Arisaka N, Harumiya S, Yamanoi K, Yamada S, Kakuta S, Kawashima H, Fukuda MN, Fukuda M, and Nakayama J
Annexin A1 expression is correlated with malignant potential of renal cell carcinoma Int. J. Urol.,26:284-290 2019 Author:Yamanoi M, Yamanoi K1, Fujii C1,2, Fukuda MN, and Nakayama J (1: Contributed equally, 2: Corresponding author)
Fascin1 suppresses RIG-I-like receptor signaling and interferon-β production by associating with IκB kinase ϵ (IKKϵ) in colon cancer J. Bilo. Chem.,293:6329-6336 2018 Author:Matsumura T, Hida S, Kitazawa M, Fujii C, Kobayashi A, Takeoka M, Taniguchi SI, Miyagawa SI
Potential Role of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells Tohoku J Exp Med,244:133-144 2018 Author:Sakaizawa T, Matsumura T, Fujii C, Hida S, Toishi M, Shiina T, Yoshida K, Hamanaka K, Ito KI, Taniguchi S
Gastric gland mucin-specific O-glycan expression decreases with tumor progression from precursor lesions to pancreatic cancer. Cancer Sci,108:1897-1902 2017 Author:Ohya A, Yamanoi K, Shimojo H, Fujii C, Nakayama J
ASC induces apoptosis via activation of caspase-9 by enhancing gap junction-mediated intercellular communication. PLoS ONE,12:e0169340 2017 Author:Kitazawa M, Hida S, Fujii C, Taniguchi S, Ito K, Matsumura T, Okada N, Sakaizawa T, Kobayashi A, Takeoka M, and Miyagawa S
Novel role of ASC as a regulator of metastatic phenotype. Cancer Med.,5:2487-2500 2016 Author:Okada N1, Fujii C1,2, Matsumura T, Kitazawa M, Okuyama R, Taniguchi S, and Hida S. (1: Contributed equally, 2: Corresponding author)
NFkB2 gene as a novel candidate that epigenetically responds to interval walking training. Int. J. Sports. Med.,36:769-775 2015 Author:Y. Zhang, S. Hashimoto, C. Fujii, S. Hida, K. Ito, T. Matsumura, T. Sakaizawa, M. Morikawa, S. Masuki, H. Nose, K. Higuchi, K. Nakajima, S. Taniguchi
Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver. Oncogene,29:2228-2237 2010 Author:Y. Wu, Y. Y. Wang, Y. Nakamoto, Y-Y. Li, T. Baba, S. Kaneko, C. Fujii, and N. Mukaida
In vivo immunological toxicity in mice of carbon nanotubes with impurities. Carbon,47:1365-1372 2009 Author:S. Koyama, Y. A. Kim, T. Hayashi, K. Takeuchi, C. Fujii, N. Kuroiwa, H. Koyama, T. Tsukahara, and M. Endo
Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression. J. Cancer Res. Clin. Oncol.,134:481-488 2008 Author:H. C. Zheng, K. Tsuneyama, H. Takahashi, S. Miwa, T, Sugiyama, B. K. Popivanova, C. Fujii, K. Nomoto, N. Mukaida, and Y. Takano
Blocking TNF-a in mice reduces colorectal carcinogenesis associated with chronic colitis. J. Clin. Invest.,118:560-570 2008 Author:B. K. Popivanova, K. Kitamura, Y. Wu, T. Kondo, T. Kagaya, S. Kaneko, M. Oshima, C. Fujii, and N. Mukaida
Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis. Cancer Sci.,98:321-328 2007 Author:B. K. Popivanova, Y-Y Li, H. Zheng, K. Omura, C. Fujii, K. Tsuneyama, and N. Mukaida
Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages, and neovascularization. Int. J. Cancer,118:335-345 2006 Author:X. Yang, P. Lu, Y. Ishida, W. A. Kuziel, C. Fujii, and N. Mukaida
Esssential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression. Int. J. Cancer,118:1869-1876 2006 Author:X. Yang, P. Lu, C. Fujii, Y. Nakamoto, J. Gao, S. Kaneko, P. M. Murphy, and N. Mukaida
Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates Bad to block Bad-mediated apoptosis in human pancreatic cancer cell lines. Cancer Res.,66:6741-6747 2006 Author:Y-Y. Li, B. K. Popivanova, Y. Nagai, H. Ishikura, C. Fujii, and N. Mukaida
Implication of ‘Down syndrome cell adhesion molecule’ in the hippocampal neurogenesis of ischemic monkeys. Hippocampus,16:924-935 2006 Author:T. Yamashima, B. K. Popivanova, J. Guo, S. Kotani, T. Wakayama, S. Iseki, K. Sawamoto, H. Okano, C. Fujii, N. Mukaida, and A. B. Tonchev
Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. Int. J. Cancer,114:209-218 2005 Author:C. Fujii, Y. Nakamoto, P. Lu, K. Tsuneyama, B. K. Popivanova, S. Kaneko, and N. Mukaida
hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitize cervical cancer cells to a low dose of cisplatin. Cancer Gene Ther.,11:1-7 2004 Author:M. Nakamura, S. Kyo, T. Kanaya, N. Yatabe, Y. Maida, M. Tanaka, Y. Ishida, C. Fujii, T. Kondo, M. Inoue, and N. Mukaida
Spontaneous regression of lung metastasis in the absence of tumor necrosis factor receptor p55. Int. J. Cancer,112:927-933 2004 Author:Y. Tomita, X. Yang, Y. Ishida, Y. Nemoto-Sasaki, T. Kondo, M. Oda, G. Watanabe, G. N. Chaldakov, C. Fujii, and N. Mukaida
Potential interaction between CCR1 and its ligand, CCL3, induced by endogenously produced interleukin-1 in human hepatomas. Am. J. Pathol.,162:1249-1258 2003 Author:P. Lu, Y. Nakamoto, Y. Nemoto-Sasaki, C. Fujii, H. Wang, M. Hashii, Y. Ohmoto, S. Kaneko, K. Kobayashi, and N. Mukaida
Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis. Lab. Invest.,82:571-583 2002 Author:K. Kitamura, Y. Nakamoto, M. Akiyama, C. Fujii, T. Kondo, K. Kobayashi, S. Kaneko, and N. Mukaida
Difference in the way of macrophage recognition of target cells depending on their apoptotic states. Cell Death Differ.,8:1113-1122 2001 Author:C. Fujii, A. Shiratsuchi, J. Manaka, S. Yonehara, and Y. Nakanishi
Essential tyrosine residues in 3-ketosteroid-Δ1-dehydrogenase from Rhodococcus rhodochrous. J. Biochem.,126:662-667 1999 Author:C. Fujii, S. Morii, M. Kadode, S. Sawamoto, M. Iwami, and E. Itagaki
3-Ketosteroid-Δ1-dehydrogenase of Rhodococcus rhodochrous：Sequencing of the genomic DNA and hyperexpression, purification, and characterization of the recombinant enzyme. J. Biochem.,124:1026-1032 1998 Author:S. Morii, C. Fujii, T. Miyoshi, M. Iwami, and E. Itagaki
Role of gastric gland mucin-specific O-glycan GlcNAc in gastric cancer development ASCB|EMBO meeting 2018(San Diego, USA) 2018(Dec.) Presenter:Chifumi Fujii, Atsuko Yuki, Satoru Harumiya, Kazuhiro Yamanoi, Masatomo Kawakubo, and Jun Nakayama
The roles of ASC in cancer cell metastasis 15th International Biennial Congress Metastasis Research Society (Germany) 2014(Jun.) Presenter:Chifumi Fujii, Tomio Matshmura, Takao Sakaizawa, Shigeaki Hida, and Shun’ichiro Taniguchi.
Actin binding protein fascin1 regulates innate immune responses in tumor cells 日本免疫学会総会・学術集会 2013(Dec.) Presenter:松村富穂、藤井千文、谷口俊一郎、肥田重明
Potential involvement of ASC in cancer progression and metastasis. 14th International Biennial Congress of the Metastasis Research Society (Australia) 2012(Sep. 02) Presenter:Chifumi Fujii, Shigeaki Hida, Masato Kitazawa, Kensuke Ito, and Shun’ichiro Taniguchi.
マクロファージの抗腫瘍作用におけるApoptosis-associated speck-like protein containing a CARD(ASC)の役割 第70回日本癌学会学術総会（名古屋） 2011(Oct.) Presenter:岡田なぎさ、北沢将人、藤井千文、肥田重明、谷口俊一郎
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