医学博士, 信州大学（日本）

膠原病、アレルギー内科学, 膠原病・アレルギー内科学

Efficacy of tocilizumab for interstitial lung disease associated with polyarticular juvenile idiopathic arthritis
Maruyama Y, Shigemura T, Kobayashi N, Nakazawa Y.
Pediatr Int ., 64(1), e14737, 2022年01月

Clinical impact of myositis-specific autoantibodies on long-term prognosis of juvenile idiopathic inflammatory myopathies: multicentre study
Yamasaki Y, Kobayashi N, Akioka S, Yamazaki K, Takezaki S, Nakaseko H, Ohara A, Nishimura K, Nishida Y, Sato S, Kishi T, Hashimoto M, Mori M, Okazaki Y, Kuwana M, Ohta A.
Rheumatology (Oxford) ., 60(10), 4821-4831, 2021年10月

Clinical practice guidance for juvenile dermatomyositis (JDM) 2018-Update.
Kobayashi I, Akioka S, Kobayashi N, Iwata N, Takezaki S, Nakaseko H, Sato S, Nishida Y, Nozawa T, Yamasaki Y, Yamazaki K, Arai S, Nishino I, Mori M.
Mod Rheumatol., 30(3), 411-423, 2020年05月

Clinical features and new diagnostic criteria for the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis.
Takeuchi Y, Shigemura T, Kobayashi N, Nagumo H, Furumoto M, Ogasawara K, Fujii H, Takizawa M, Soga T, Matoba H, Masumoto J, Fukushima K, Migita K, Ojima T, Umeda Y, Agematsu K.
Int J Rheum Dis., 22(8), 1489-1497, 2019年08月

Mosaicism of an ELANE Mutation in an Asymptomatic Mother
Shigemura T, Kobayashi N, Agematsu K, Ohara O, Nakazawa Y.
J Clin Immunol., 39(1), 106-111, 2019年01月

Analysis of biomarker serum levels in IVIG and infliximab refractory Kawasaki disease patients.
Hachiya A, Kobayashi N, Matsuzaki S, Takeuchi Y, Akazawa Y, Shigemura T, Motoki N, Masumoto J, Agematsu K.
Clin Rheumatol., 37(7), 1937, 2018年

Characteristics and outcome of intractable vasculitis syndrome in children: Nation-wide survey in Japan.
Nakano N, Mori M, Umebayashi H, Iwata N, Kobayashi N, Masunaga K, Imagawa T, Murata T, Kinjo N, Nagai K, Miyoshi M, Takei S, Yokota S, Ishii E.
28(4), 697, 2018年

Heterozygous Mutations in OAS1 Cause Infantile-Onset Pulmonary Alveolar Proteinosis with Hypogammaglobulinemia.
Cho K, Yamada M, Agematsu K, Kanegane H, Miyake N, Ueki M, Akimoto T, Kobayashi N, Ikemoto S, Tanino M, Fujita A, Hayasaka I, Miyamoto S, Tanaka-Kubota M, Nakata K, Shiina M, Ogata K, Minakami H, Matsumoto N, Ariga T.
Am J Hum Genet., 102(3), 480, 2018年

Infliximab versus intravenous immunoglobulin for refractory Kawasaki disease: a phase 3, randomized, open-label, active-controlled, parallel-group, multicenter trial.
Mori M, Hara T, Kikuchi M, Shimizu H, Miyamoto T, Iwashima S, Oonishi T, Hashimoto K, Kobayashi N, Waki K, Suzuki Y, Otsubo Y, Yamada H, Ishikawa C, Kato T, Fuse S.
Sci Rep., 8(1), 2018年

A Pediatric Case of Relapsing-Remitting Multiple Sclerosis Onset following Varicella Zoster Ophthalmicus with Optic Neuritis.
Shiba N, Inaba Y, Motobayashi M, Nishioka M, Kawasaki Y, Noda S, Matsuura H, Kobayashi N, Matsuoka T, Nakamura A, Nakazawa Y.
Case Rep Pediatr, 2018年

Analysis of serum IL-38 in juvenile-onset systemic lupus erythematosus. Agematsu K.
Takeuchi Y, Seki T, Kobayashi N, Sano K, Shigemura T, Shimojo H, Matsumoto K, Agematsu K.
Mod Rheumatol., 2018年

Early diagnosis of early-onset sarcoidosis: a case report with functional analysis and review of the literature.
Takeuchi Y, Shigemura T, Kobayashi N, Kaneko N, Iwasaki T, Minami K, Kobayashi K, Masumoto J, Agematsu K.
Clin Rheumatol., 36(5), 1189, 2017年, 査読有り

IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10.
Chen L, Al-Kzayer LF, Liu T, Kobayashi N, Nakazawa Y, Koike K.
Pediatr Blood Cancer, 64(2), 311, 2017年, 査読有り

Acute Myeloid Leukemia in a Patient With X-linked Severe Combined Immunodeficiency.
Shigemura T, Motobayashi M, Matsuda K, Shimodaira T, Kurata T, Kobayashi N, Agematsu K, Nakazawa Y.
J Pediatr Hematol Oncol., 2017年, 査読有り

Markedly elevated CD64 expression on neutrophils and monocytes as a biomarker for diagnosis and therapy assessment in Kawasaki disease
Hokibara, Sho; Kobayashi, Norimoto; Kobayashi, Keiko; Shigemura, Tomonari; Nagumo, Haruo; Takizawa, Masahiro; Yamazaki, Takashi; Agematsu, Kazunaga;
INFLAMMATION RESEARCH, 65(7), 579-585, 2016年07月

Immune Complex-Mediated Glomerulonephritis in a Patient with Wiskott-Aldrich Syndrome
Shigemura, Tomonari; Nakazawa, Yozo; Shimojo, Hisashi; Kobayashi, Norimoto; Agematsu, Kazunaga;
JOURNAL OF CLINICAL IMMUNOLOGY, 36(4), 357-359, 2016年05月

A novel surfactant protein C L55F mutation associated with interstitial lung disease alters subcellular localization of proSP-C in A549 cells
Liu, Tingting; Sano, Kenji; Ogiwara, Naoko; Kobayashi, Norimoto;
PEDIATRIC RESEARCH, 79(1), 27-33, 2016年01月

Novel heterozygous C243Y A20/TNFAIP3 gene mutation is responsible for chronic inflammation in autosomal-dominant Behçet's disease.
Shigemura T, Kaneko N, Kobayashi N, Kobayashi K, Takeuchi Y, Nakano N, Masumoto J, Agematsu K.
RMD open, 2(1), 2016年, 査読有り

IL-18 serum concentration is markedly elevated in typical familial Mediterranean fever with M694I mutation and can distinguish it from atypical type
Yamazaki, Takashi; Shigemura, Tomonari; Kobayashi, Norimoto; Honda, Kimiko; Yazaki, Masahide; Masumoto, Junya; Migita, Kiyoshi; Agematsu, Kazunaga;
MODERN RHEUMATOLOGY, 26(2), 315-317, 2016年

Increased Serum B Cell Activating Factor and a Proliferation-inducing Ligand Are Associated with Interstitial Lung Disease in Patients with Juvenile Dermatomyositis
Kobayashi, Norimoto; Kobayashi, Ichiro; Mori, Masaaki; Sato, Shinji; Iwata, Naomi; Shigemura, Tomonari; Agematsu, Kazunaga; Yokota, Shumpei; Koike, Kenichi;
JOURNAL OF RHEUMATOLOGY, 42(12), 2412-2418, 2015年12月

Cytomegalovirus Encephalitis in a Patient with Severe Combined Immunodeficiency
Motobayashi, Mitsuo; Shigemura, Tomonari; Tanaka, Miyuki; Kurata, Takashi; Kobayashi, Norimoto; Agematsu, Kazunaga; Amano, Yoshiro; Inaba, Yuji; Koike, Kenichi; Nakazawa, Yozo;
JOURNAL OF CLINICAL IMMUNOLOGY, 35(8), 689-691, 2015年11月

若年性皮膚筋炎における間質性肺病変 (特集 小児リウマチ性疾患の最新治療) -- (その他の膠原病)
小林 法元;
小児科診療, 78(8), 1109-1114, 2015年08月

Clinical and laboratory features of fatal rapidly progressive interstitial lung disease associated with juvenile dermatomyositis
Kobayashi, Norimoto; Takezaki, Shunichiro; Kobayashi, Ichiro; Iwata, Naomi; Mori, Masaaki; Nagai, Kazushige; Nakano, Naoko; Miyoshi, Mari; Kinjo, Noriko; Murata, Takuji; Masunaga, Kenji; Umebayashi, Hiroaki; Imagawa, Tomoyuki; Agematsu, Kazunaga; Sato, Shinji; Kuwana, Masataka; Yamada, Masafumi; Takei, Shuji; Yokota, Shumpei; Koike, Kenichi; Ariga, Tadashi;
RHEUMATOLOGY, 54(5), 784-791, 2015年05月

Clinical and laboratory features of fatal rapidly progressive interstitial lung disease associated with juvenile dermatomyositis
Kobayashi, Norimoto; Takezaki, Shunichiro; Kobayashi, Ichiro; Iwata, Naomi; Mori, Masaaki; Nagai, Kazushige; Nakano, Naoko; Miyoshi, Mari; Kinjo, Noriko; Murata, Takuji; Masunaga, Kenji; Umebayashi, Hiroaki; Imagawa, Tomoyuki; Agematsu, Kazunaga; Sato, Shinji; Kuwana, Masataka; Yamada, Masafumi; Takei, Shuji; Yokota, Shumpei; Koike, Kenichi; Ariga, Tadashi;
RHEUMATOLOGY, 54(5), 784-791, 2015年05月

An Increase in Circulating B Cell-Activating Factor in Childhood-Onset Ocular Myasthenia Gravis
Motobayashi, Mitsuo; Inaba, Yuji; Nishimura, Takafumi; Kobayashi, Norimoto; Nakazawa, Yozo; Koike, Kenichi;
PEDIATRIC NEUROLOGY, 52(4), 404-409, 2015年04月

Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes
Nakagawa, Kenji; Gonzalez-Roca, Eva; Souto, Alejandro; Kawai, Toshinao; Umebayashi, Hiroaki; Maria Campistol, Josep; Canellas, Jeronima; Takei, Syuji; Kobayashi, Norimoto; Luis Callejas-Rubio, Jose; Ortego-Centeno, Norberto; Ruiz-Ortiz, Estibaliz; Rius, Fina; Anton, Jordi; Iglesias, Estibaliz; Jimenez-Trevino, Santiago; Vargas, Carmen; Fernandez-Martin, Julian; Calvo, Inmaculada; Hernandez-Rodriguez, Jose; Mendez, Maria; Teresa Dordal, Maria; Basagana, Maria; Bujan, Segundo; Yashiro, Masato; Kubota, Tetsuo; Koike, Ryuji; Akuta, Naoko; Shimoyama, Kumiko; Iwata, Naomi; Saito, Megumu K.; Ohara, Osamu; Kambe, Naotomo; Yasumi, Takahiro; Izawa, Kazushi; Kawai, Tomoki; Heike, Toshio; Yaguee, Jordi; Nishikomori, Ryuta; Arostegui, Juan I.;
ANNALS OF THE RHEUMATIC DISEASES, 74(3), 603-610, 2015年03月

Successful treatment for West syndrome with severe combined immunodeficiency
Motobayashi, Mitsuo; Inaba, Yuji; Fukuyama, Tetsuhiro; Kurata, Takashi; Niimi, Taemi; Saito, Shoji; Shiba, Naoko; Nishimura, Takafumi; Shigemura, Tomonari; Nakazawa, Yozo; Kobayashi, Norimoto; Sakashita, Kazuo; Agematsu, Kazunaga; Ichikawa, Motoki; Koike, Kenichi;
BRAIN & DEVELOPMENT, 37(1), 140-144, 2015年01月

Dramatic Improvement in the Multifocal Positron Emission Tomography Findings of a Young Adult with Chronic Granulomatous Disease Following Allogeneic Hematopoietic Stem Cell Transplantation
Shigemura, Tomonari; Nakazawa, Yozo; Hirabayashi, Koichi; Kobayashi, Norimoto; Sakashita, Kazuo; Agematsu, Kazunaga; Koike, Kenichi;
JOURNAL OF CLINICAL IMMUNOLOGY, 35(1), 84-86, 2015年01月

Dramatic Improvement in the Multifocal Positron Emission Tomography Findings of a Young Adult with Chronic Granulomatous Disease Following Allogeneic Hematopoietic Stem Cell Transplantation
Shigemura, Tomonari; Nakazawa, Yozo; Hirabayashi, Koichi; Kobayashi, Norimoto; Sakashita, Kazuo; Agematsu, Kazunaga; Koike, Kenichi;
JOURNAL OF CLINICAL IMMUNOLOGY, 35(1), 84-86, 2015年01月

Clinical Course in a Patient With Neutrophil-Specific Granule Deficiency and Rapid Detection of Neutrophil Granules as a Screening Test
Shigemura, Tomonari; Yamazaki, Takashi; Shiohara, Masaaki; Kobayashi, Norimoto; Naganuma, Kuniaki; Koike, Kenich; Agematsu, Kazunaga;
JOURNAL OF CLINICAL IMMUNOLOGY, 34(7), 780-783, 2014年10月

Serial monitoring of Mucorales DNA load in serum samples of a patient with disseminated mucormycosis after allogeneic bone marrow transplantation
Shigemura, Tomonari; Nakazawa, Yozo; Matsuda, Kazuyuki; Sano, Kenji; Yaguchi, Takashi; Motobayashi, Mitsuo; Saito, Shoji; Noda, Shunsuke; Kobayashi, Norimoto; Agematsu, Kazunaga; Honda, Takayuki; Koike, Kenichi;
INTERNATIONAL JOURNAL OF HEMATOLOGY, 100(2), 206-209, 2014年08月

Successful cord blood transplantation after repeated transfusions of unmobilized neutrophils in addition to antifungal treatment in an infant with chronic granulomatous disease complicated by invasive pulmonary aspergillosis
Shigemura, Tomonari; Nakazawa, Yozo; Yoshikawa, Kentaro; Hirabayashi, Koichi; Saito, Shoji; Kobayashi, Norimoto; Sakashita, Kazuo; Shiohara, Masaaki; Wada, Taizo; Shimodaira, Shigetaka; Agematsu, Kazunaga; Koike, Kenichi;
TRANSFUSION, 54(3), 516-521, 2014年03月

Clinical Utility of Anti-CADM-140/Melanoma Differentiation-Associated Gene 5 Autoantibody Titers in Patients with Juvenile Dermatomyositis and Rapidly Progressive Interstitial Lung Disease
Sato, Shinji; Kobayashi, Norimoto; Yamazaki, Kazuko; Suzuki, Yasuo;
ARTHRITIS AND RHEUMATISM, 64(10), S128-S128, 2012年10月

Food allergy after cord blood transplantation in children.
Sakashita K, Nakazawa Y, Yanagisawa R, Tanaka M, Saito S, Yoshikawa K, Hirabayashi K, Kusakari M, Kato S, Hidaka N, Nakayama Y, Shigemura T, Kobayashi N, Kobayashi M, Shiohara M, Koike K.
Br J Haematol, 158(5), 1365, 2012年09月

TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells.
Albacker LA, Karisola P, Chang YJ, Umetsu SE, Zhou M, Akbari O, Kobayashi N, Baumgarth N, Freeman GJ, Umetsu DT, DeKruyff RH.
J Immunol, 185(11), 6839-49, 2010年

Distinct response in maintenance of human naive and memory B cells via IL-21 receptor and TCL1/Akt pathways.
Nagumo H, Abe J, Kano H, Taki S, Yamazaki K, Yamazaki T, Kobayashi N, Koike K, Sugane K, Saito H, Agematsu K.
Cell Immunol, 256(1-2), 56, 2009年

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.
Kobayashi N, Karisola P, Peña-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ
Immunity, 27(6), 927-40, 2007年

Differential effects of short-acting beta(2)-agonists on human granulocyte functions
Yasui, K; Kobayashi, N; Yamazaki, T; Agematsu, K; Matsuzaki, S; Nakata, S; Baba, A
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 139(1), 1-8, 2006年

Successful treatment with methotrexate of a child with atlantoaxial subluxation from enthesitis-related arthritis
Kobayashi, N; Yasui, K; Nagumo, H; Agematsu, K; Koike, K
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 24(2), 211-212, 2006年

CD30+anaplastic large cell lymphoma complicated by pyoderma gangrenosum with increased levels of serum cytokines
Saito, S; Yasui, K; Hosoda, W; Ogawa, M; Kobayashi, N; Sakashita, K; Koike, K
EUROPEAN JOURNAL OF HAEMATOLOGY, 77(3), 251-254, 2006年

Polarization of Th1/Th2 in human CD4+ T cells separated by CD62L: analysis by transcription factors
Matsuzaki S, Shinozaki K, Kobayashi N, Agematsu K
ALLERGY, 60, 780-787, 2005年

Superoxide dismutase (SOD) as a potential inhibitory mediator ofinflammation via neutrophil apoptosis
Yasui K, Kobayashi N, Yamazaki T, Agematsu K, Matsuzaki S, Ito S, Nakata S, Baba A, Koike K
Free Radic Res, 39, 755-762, 2005年

Neutrophilic inflammation in childhood bronchial asthma
Yasui K, Kobayashi N, Yamazaki T, Koike K, Fukushima K, Taniuchi S, Kobayashi Y
Thorax, 60, 704-705, 2005年

Neutrophil-mediated inflammation in respiratory syncytial viral bronchiolitis
Yasui K, Baba A, Iwasaki Y, Kubo T, Aoyama K, Mori T, Yamazaki T, Kobayashi N, Ishiguro A
Pediatr Int, 47, 190-195, 2005年

Effective combination therapy using interferon-gamma and interleukin-2 for disseminated Mycobacterium avium complexinfection in a pediatric patient with AIDS
Sekiguchi Y, Yasui K, Yamazaki T, Agematsu K, Kobayashi N, Koike K
Clin Infect Dis, 41, e104-e106, 2005年

Thalidomide as an immunotherapeutic agent: The effects on neutrophil-mediated inflammation
Yasui, K; Kobayashi, N; Yamazaki, T; Agematsu, K
Current Pharmaceutical Design, 11(3), 395-401, 2005年

Bilineage acute leukemia of T-lymphoid and myeloid lineages
Kobayashi N, Matsuda K, Sakashita K, Matsuzaki S, Iwasaki R, Koike K
Haematologica, 89, 1139-1141, 2004年

Expansion of clonotype-restricted HLA-identical maternal CD4+ T cells in a patient with severe combined immunodeficiency and a homozygous mutation in the Artemis gene
Kobayashi N, Agematsu K, Nagumo H, Yasui K, Katsuyama Y, Yoshizawa K, Ota M, Yachie A, Komiyama A
Clin Immunol, 108, 159-166, 2003年

Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families
Kobayashi N, Agematsu K, Sugita K, Sako M, Nonoyama S, Yachie A, Kumaki S, Tsuchiya S, Ochs HD, Sugita K, Fukushima Y, Komiyama A
Hum Genet, 112, 348-352, 2003年

IL-10 enhances B-cell IgE synthesis by promoting differentiation into plasma cells, a process that is inhibited by CD27/CD70 interaction
Kobayashi N, Nagumo H, Agematsu K
Clin Exp Immunol, 129, 446-452, 2002年

Absence of memory B cells in patients with common variable immunodeficiency
Agematsu K, Futatani T, Hokibara N, Kobayashi H, Takamoto M, Tsukada S, Suzuki H, Koyasu S, Miyawaki T, Sugane K, Komiyama A, Ochs HD
Clin Immunol, 103, 34-42, 2002年

Interferon-gamma and interteukin-2 combination therapy for a AIDS girl with mycobacterium avium-intracellulare complex infection.
Sekiguchi, Y; Kobayashi, N; Nagumo, H; Agematsu, K; Komiyama, A
Clinical Immunology, 103(3), S78-S78, 2002年

The different process of class switching and somatic hypermutation; a novel analysis by CD27(-) naive B cells
Nagumo, H; Agematsu, K; Kobayashi, N; Shinozaki, K; Hokibara, S; Nagase, H; Takamoto, M; Yasui, K; Sugane, K; Komiyama, A
BLOOD, 99(2), 567-575, 2002年

日本小児科学会

日本リウマチ学会

日本小児リウマチ学会

日本アレルギー学会

MDA5,抗MDA5抗体の機能解析による重症間質性肺障害発症機構の解明
科学研究費補助金, 基盤研究(C)
2016年 - 2018年

日本小児リウマチ学会誌, 2020年