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小栁 清光  オヤナギ キヨミツ

教員組織電話番号
教育組織医学部 医学科 神経難病学(寄附講座)FAX番号
職名特任教授メールアドレスk123ysm@shinshu-u.ac.jp
住所〒114-0003 東京都北区豊島8-27-3-705ホームページURL

プロフィール

研究分野
神経解剖学・神経病理学
キーワード:神経 , 病理
現在の研究課題
筋萎縮性側索硬化症
キーワード:運動ニューロン
パーキンソン病
キーワード:黒質 , ドパミン
病巣修復
キーワード:神経細胞 , 脊髄
認知症
キーワード:タウ
所属学会
所属学会
日本神経病理学会
米国神経学会
日本神経学会

所属学会役職担当
日本神経病理学会 , 名誉会員
学歴
出身大学院
1980 , 新潟大学大学院

出身学校・専攻等(大学院を除く)
1976 , 新潟大学

取得学位
医学博士 , 新潟大学
受賞学術賞
2016 , 信州大学医学部長顕彰
2002 , 米国神経病理学会ワイル賞(Weil Award)
2002 , 東京都知事表彰
1996 , 「生命の彩」ALS研究助成基金
1993 , 新潟県医師会学術奨励賞
研究職歴等
研究職歴
2015- , 信州大学医学部特任教授
2010- , 信州大学医学部教授
2003- , 東京都神経科学総合研究所参事
1996- , 東京都神経科学総合研究所副参事
1989- , 新潟大学脳研究所助教授
1980- , 新潟大学脳研究所助手

留学歴
1980- , 米国国立衛生研究所研究科学員

研究活動業績

研究業績(著書・
発表論文等)
書籍等出版物
B.中枢神経の所見の取り方, 病理と臨床(臨時増刊) 30 , 149-157
2012
Author:橋本智代、小柳清光


Parkinsonism-Dementia Complex of Guam, Neurodegeneration the molecular pathology of dementia and movement disorders , 171-178
Wiley-Blackwell 2011
Author:Kiyomitsu Oyanagi, Tomoyo Hashimoto, Mineo Yamazaki


Magnesium in Parkinson's disease: an update in clinical and basic aspects, Magnesium in the Central Nervous System , 229-236
University of Adelaide Press 2011
Author:Oyanagi K, Hashimoto T


論文
Dysfunction of protein quality control in parkinsonism-dementia compex of Guam
Froniiers of Neurology,9:173 2018(Mar.)
Author:Verheijen BM, Oyanagi K, van Leeuwen FW


Atypical lower motor neuron disease with enlargement of Nissl substance: report of an autopsy case
Clinical Neuropathology,37(2):74-81 2018(Feb.)
Author:Shintaku M, Kaneda D, Oyanagi K


Deposition of mutant ubiquitin in parkinsonism-dementia complex of Guam
Acta Neuropathologica Communications,5:82 2017
Author:Verheijen BM, Hashimoto T, Oyanagi K, van Leeuwen FW


Novel intracytoplasmic inclusions immunopositive for phosphorylated-TDP43 and cystatin C in anterior horn cells in a case of sporadic amyotrophic lateral sclerosis
Neuropathology,37:526-534 2017
Author:Shintaku M, Kaneda D, Oyanagi K


An autopsy case of respiratory failure induced by repetitive cervical spinal cord damage due to abnormal movement of the neck in athetoid palsy
Internal Medicine,56:1425-1430 2017
Author:Takei Y, Koshihara H, Oguchi K, Oyanagi K, Ohara S


Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and Nasu-Hakola disease: Lesion staging and dynamic changes of axons and microglial subsets.
Brain Pathol,27:748-769 2017
Author:Oyanagi K, Kinoshita M, Suzuki-Kouyana E, Inoue T, Nakahara A, Tokiwai M, Arai N, Satoh JI, Aoki N, Jinnai K, Yazawa I, Arai K, Ishihara K, Kawamura M, Ishizawa K, Hasegawa K, Yagisita S, Amano N, Yoshida K, Terada S, Yoshida M, Akiyama H, Mitsiyama Y, Ikeda S.


Shinshu Brain Resource Net.
Neuropathology,36(6):600-601 2016(Dec.)
Author:Oyanagi K, Yamada M, Hineno A, Yahikozawa H, Ushiyama M, Miki J, Kanno H, Nakayama J, Makishita H, Inoue K, Ohara S, Hayashida K, Kayanuma K, Yamamoto K, Yasude T, Hashimoto T, Yoshida K, Ikeda SI.


Axonal TDP-43 aggregates in sporadic amyotrophic lateral sclerosis.
Neuropathol Appl Neurobiol,42(6):561-72 2016(Oct.)
Author:Onozato T, Nakahara A, Suzuki-Kouyama E, Hineno A, Yasude T, Nakamura T, Yahikozawa H, Watanabe M, Kayanuma K, Makishita H, Ohara S, Hashimoto T, Higuchi K, Sakai T, Asano K, Hashimoto T, Kanno H, Nakayama J, Oyanagi K.


Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication Stage V).
Acta Neuropathol Commun,4(1):107 2016(Sep.)
Author:Hayashi K, Mochizuki Y, Takeuchi R, Shimizu T, Nagao M, Watabe K, Arai N, Oyanagi K, Onodera O, Hayashi M, Takahashi H, Kakita A, Isozaki E.


【認知症の診断・臨床・治療とケア、認知症の人のWell-being】 アルツハイマー病診療のスキルアップを考える この症例をどう診るか2015
老年精神医学雑誌,27(増刊I):7-30 2016(Mar.)
Author:笠貫浩史, 上村直人, 柳川まどか, 唐木千穂, 小柳清光, 山崎峰雄, 梅垣宏行, 繁田雅弘


SOD1遺伝子L106V変異家族性筋萎縮性側索硬化症における下部尿路機能障害の発現時期と排尿神経機構の病理所見
臨床神経学,56(2):69-76 2016(Feb.)
Author:日根野晃代, 小柳清光, 中村昭則, 下島吉雄, 吉田邦広, 池田修一


多数のびまん性老人斑とpretangle、neuropil threadを合併した、認知症をともなう筋萎縮性側索硬化症の1剖検例
臨床神経学,55(5):362-363 2015(May)
Author:青木寧子, 望月葉子, 磯崎英治, 板東充秋, 小柳清光, 水谷俊雄


【神経病理診断の標準化I】 基本的な評価法 神経細胞とその突起の変化について
病理と臨床,33(3):234-241 2015(Mar.)
Author:小柳清光, 橋本智代, 中原亜紗, 山崎峰雄


臨床診断 脊髄小脳変性症(SCA6)、口唇ジスキネジア、卵巣癌
信州医学雑誌,63(1):41-46 2015(Feb.)
Author:吉田邦広, 北沢邦彦, 岩谷舞, 小柳清光, 木下朋実, 中村勝哉, 関島良樹, 清水雄策, 高昌星, 水澤英洋


臨床診断 脊髄小脳変性症(SCA31)
信州医学雑誌,63(1):46-49 2015(Feb.)
Author:吉田邦広, 酒井寿明, 小見山祐一, 小柳清光, 清水雄策, 水澤英洋, 中村勝哉


Hippocampal sclerosis in the parkinsonism-dementia complex of Guam: quantitative examination of neurons, neurofibrillary tangles, and TDP-43 immunoreactivity in CA1.
Neuropathology,35(3):224-35 2015(Jan.)
Author:Oyanagi K, Yamazaki M, Hashimoto T, Asakawa M, Wakabayashi K, Takahashi H.


Predictors of impaired communication in amyotrophic lateral sclerosis patients with tracheostomy-invasive ventilation.
Amyotroph Lateral Scler Frontotemporal Degener,17(1-2):38-46 2015
Author:Nakayama Y, Shimizu T, Mochizuki Y, Hayashi K, Matsuda C, Nagao M, Watabe K, Kawata A, Oyanagi K, Isozaki E, Nakano I.


Development of primary central nervous lymphoma associated with human immunodeficiency virus and JC virus infection.
J Clin Exp Hematopathol 2014
Author:Kawakami T, Sakai K, Mimura Y, Senoo Y, et al.


Zinc Transporters (ZnT3 and 6) Are Downregulated in the Spinal Cords of Patients with Sporadic Amyotrophic Lateral Sclerosis.
J Neurosci Res,93(2):370-379 2014
Author:Kaneko M, Noguchi T, Ikegami S, Oyanagi K, Inuzuka T, Takahashi H, Hozumi I.


Hippocampal sclerosis in the parkinsonism-dementia complex of Guam: quantitative examination of neurons, neurofibrillary tangles, and TDP-43 immunoreactivity in CA1.
Neuropathology 2014
Author:Oyanagi K, Yamazaki M, Hashimoto T, Asakawa M, Wakabayashi K, Takahashi H.


Mannitol infusion immediately after reperfusion suppresses the development of focal cortical infarction after temporary cerebral ischemia in gerbils.
Neuropathology,34(4):360-369 2014
Author:Ito U, Hakamata Y, Watabe K, Oyanagi K


Distinctive features of degenerating Purkinje cells in spinocerebellar ataxia type 31.
Neuropathology,34:261-267 2014
Author:Yoshida K, Asakawa M, Suzuki-Kouyama E, Tabata K, Shintaku M, Ikeda S, Oyanagi K


Comparative study of fibrin and chemical synthetic sealant on dural regeneration and brain damage.
Neurosurg 2014
Author:Ito K, Horiuchi T, Oyanagi K, Nomiyama T, Hongo K


An autopsy case of familial amyotrophic lateral sclerosis with FUS R521G mutation.
Amyotroph Lateral Scler Frontotemporal Degener,15:305-308 2014
Author:Mochizuki Y, Kawata A, Hashimoto T, Akiyama H, Kawakami H, Komori T, Oyanagi K, Mizutani T, Matsubara S


“Gliomatosis encephali” as s novel category of brain tumor by the first autopsy case report of gliomatosis cerebelli.
Neuropathology,34:295-303 2014
Author:Nakahara A, Yoshida T, Yazawa M, Ehara T, Nakayama J, Kakita A, Ogura R, Asakawa M, Suzuki-Kouyama E, Oyanagi K


Pathological features of FTLD-FUS in a Japanese population: analyses of nine cases
J Neurol Sci,335:89-95 2013
Author:Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H


Distinctive clinicopathological features of 2 large families with amyotrophic lateral sclerosis having L106V mutation in SOD1 gene
J Neurol Sci,319:63-74 2012
Author:Hineno A, Nakamura A, Shimojima Y, Yoshida K, Oyanagi K, Ikeda S


Familial ALS with FUS P525L mutation: two Japanese sisters with multiple system involvement
J Neurol Sci,323:85-92 2012
Author:Mochizuki Y, Isozaki E, Takao M, Hashimoto T, Shibuya M, Arai M, Hosokawa M, Kawata A, Oyanagi K, Mihara B, Mizutani T


Hereditary diffuse leukoencephalopathy with axonal spheroids caused by R782H mutation in CSF1R: Case report
J Neurol Sci,318:115-118 2012
Author:Kinoshita, M., Yoshida, K., Oyanagi, K., Hashimoto, T., Ikeda, S


異常TDP-43蓄積と神経細胞死:筋萎縮性側索硬化症(ALS)と前頭側頭葉変性症(FTLD)における観察と考察
信州医誌,59(2):63-73 2011
Author:小柳清光、橋本智代


先行感染後に発症した抗AQP4抗体陽性の視神経脊髄炎84歳男性剖検例
臨床神経学,51:583-589 2011
Author:佐藤俊一、星研一、渡辺正秀、日根野晃代、小柳清光、矢彦沢裕之


Temporary focal cerebral ischemia results in swollenn astrocytic end-feet that compress microvessels and lead to focal cortical infarction
Journal of Cerebral Blood Flow and Metabolism,31:328-338 2011
Author:Ito U, Hakamata Y, Kawakami E, Oyanagi K


Radiologic and neuropathologic findings in patients in afamily with dentatorubral-pallidoluysian atrophy
Ameerican Journal of Neuroradiology,32:109-114 2011
Author:Sunami Y, Koide R, Arai N, Yamada M, Mizutani T, Oyanagi K


Survival motor neuron (SMN) protein in the spinal anterior horn cells of patients with sporadic amyotrophic lateral sclerosis
Brain Research,1372:152-159 2011
Author:Piao Y, Hashimoto T, Takahama S, Kakita A, Komori T, Morita T, Takahashi H, Mizutani T, Oyanagi K


Distinctive expression of midkine in the repair period of rat brain during neurogenesis : Immunohistochemical and immunoelectron microscopic observations
J.Neurosci Res,75(5):678-687 2004
Author:Kikuchi-Horie, K; Kawakami, E; Kamata, M; Wada, M; Hu, JG; Nakagawa, H; Ohara, K; Watabe, K; Oyanagi, K


Temporal profile of experimental ischemic edema after threshold amount of insult to induce infarction-ultrastructure, gravimetry and Evans' blue extravasation
Acta Neurochir,86(Suppl):131-135 2003
Author:Ito U, Kuroiwa T, Hanyu S, Hatanaka Y, Kawakami E, Nakano I, Oyanagi K


Pathological involvement of the motor neuron system and hippocampal formation in motor neuron disease -inclusion dementia
Acta Neuropathologica ,106(1):50-56 2003
Author:Toyoshima, Y; Piao, YS; Tan, CF; Morita, M; Tanaka, M; Oyanagi, K; Okamoto, K; Takahashi, H


Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein
J Neurochemistry ,87(1):257-267 2003
Author:Hoshino, M; Tagawa, K; Okuda, T; Murata, M; Oyanagi, K; Arai, N; Mizutani, T; Kanazawa, I; Wanker, EE; Okazawa, H


Widespread vertebral and venous plexus metastasis of prostatic carcinoma presenting wedge-shaped radial lesions in the spinal cord
Neuropathology,23(4):296-300 2003
Author:Oyanagi, K; Ogata, K; Takeda, S; Horikawa, Y; Kawakami, E; Morita, T


Topical instillation of ciliary neurotrophic factor inhibits retinal degeneration in streptozotocin -induced diabetrc rats
Neuro Report ,14(16):2067-2071 2003
Author:Aizu, Y; Katayama, H; Takahama, S; Hu, JG; Nakagawa, H; Oyanagi, K


Neuropathology with clinical correlations of sporadic amyotrophic lateval sclerosis: 102 autopsy cases examined between 1962 and 2000
Brain Pathology ,12:10-22 2003
Author:Piao, YS; Wakabayashi, K; Kakita, A; Yamada, M; Hayashi, S; Morita, T; Ikuta, F; Oyanagi, K; Takahashi, H


Enhanced SUMOylation in Polyglutamine disease
BBRC,293(1):307-313 2002
Author:Ueda, H; Goto, J; Hashida, H; Lin, X; Oyanagi, K; Kawano, H; Zoghbi, HY; Kanazawa, I; Okazawa, H


Alteration of midkine expressim in the isehemic brain of humans
J Neurological Sciences,200(1-2):67-73 2002
Author:Wada, M; Kamata, M; Aizu, Y; Morita, T; Hu, JG; Oyanagi, K


Degeneration of retinal neuronal processes and pigment epithelium in the early stage of the streptozotocirl-diabetic rats
Neuropathology,22(3):161-170 2002
Author:Aizu, Y; Oyanagi, K; Hu, JG; Nakagawa, H


Neuronal nuclear alterations in dentatorubural-pallidoluysian atrophy:ultrastructural and morphometric studies of the cerebellar granule cells
Brain Research,919(1):12-19 2001
Author:Takahashi, H; Egawa, S; Piao, YS; Hayashi, S; Yamada, M; Shimohata, T; Oyanagi, K; Tsuji, S


Progressive supranuclear palsy on Guam,
Acta Neuropathologica,102(5):510-514 2001
Author:Yamazaki,M., Makifuchi,T., Chen, K-M., Mori,O., Katayama,Y., Takahashi,H., Oyanagi,K.,


Distribution of basal ganglia lesions in generalized variant of Pick's disease: a clinicopathological study of four autopsy cases,
Acta Neuropathologica,102(5):441-448 2001
Author:Tsuchiya,K., Ishizu,H., Nakano,I., Kita,Y., Sawabe,M.,Haga,K., Kuyama,K., Nishinaka,T., Oyanagi,K., Ikeda,K., kuroda,S.,


Expression of calbindin D-28k and parvalbumin in cerebral cortical dysgenesis induced by administration of ethylnitrosourea to rats at the stage of neurogenesis,
Acta Neuropathologica,101(4):375-382 2001
Author:Oyanagi,K., Kakita,A., Kawasaki,K., Hayashi,S., Yamada,M.,


Substantia nigra in progressive supranuclear palsy, corticobasal degeneration, and parkinsonism-dementia complex of Guam: specific pathological features.,
J Neuropathol Exp Neurol,60(4):393-402 2001
Author:Oyanagi,K., Tsuchiya,K., Yamazaki,M., I,keda,K.,


Adenoviral gene transfer of glial cell line-derived neurotrophic factor to injured adult motoneurons.,
Hum Cell,14:7-15 2001
Author:Watabe,K., Sakamoto,T., Ohashi,T., Kawazoe,Y., Oyanagi,K., Takeshima,T., Inoue,K., Eto,Y., Kim,S.U.,


Establishment and characterization of immortalized Schwann cells from murine model of Niemann-Pick disease type C (spm/spm).,
J Peripher Nerv Syst,6(2):85-94 2001
Author:Watabe,K., Ida,H., Uehara,K., Oyanagi,K., Sakamoto,T., Tanaka,J., Garver,W.S., Miyawaki,S., Ohno,K., Eto,Y.,


Parkinsonism, dementia and vertical gaze palsy in a Guamanian with atypical neuroglial degeneration
Acta Neuropathol,99(1):73-80 2000
Author:Oyanagi, K., Chen, K-M., Craig, U.K., Yamazaki, M., Perl, D.P.,


alpha-synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam
J Neuropathol Exp Neurol,59(7):585-591 2000
Author:Yamazaki, M., Arai, Y., Baba, M., Iwatsubo, T., Mori, O., Katayama, Y., Oyanagi, K.,


Endothelin-1 in the brain of patients with galactosialidosis: its abnormal increase and distribution pattern
Annals of Neurol,47(1):122-126 2000
Author:Itoh, K., Oyanagi, K., Takahashi, H., Sato, T., Hashizume, N., ShimmOtO, M., SakUraba, H.,


Amyotrophic lateral sclerosis: increased hyaluronic acid in the media of the basilar artery
J Neurol Sci,167(2):112-116 1999
Author:Oyanagi, K., Nagao, K., Ono, S.,


Pursuit of the origin of the large myelinated tibers of the anterolateral funiculus in the spinal cord in humans in relation to the pathomechanism in amyotrophic lateral sclerosis
Acta Neuropathologica,98(6):635-640 1999
Author:Oyanagi, K., Kawakami, E., Morita, T., Takahashi, H.


Variant Gerstmann-Straussler syndrome with the P1O5L pion gene mutation: an unusual case with nigral degeneration and widespread neurofibrillary tan・・・
Acta Neuropathologica,98(5):506-511 1999
Author:Yamazaki, M., Oyanagi, K., Mori, O., Kitamura, S., Ohyama, M., Terashi, A., Kitamoto, T., Katayama, Y.,


Bunina bodies in amyotrophic lateral sclerosis on Guam: a histochemical, immunohistochemical and ultrastructural investigation
Acta Neuropathologica,98(2):150-156 1999
Author:Wada,M.,Uchihara,T.,Nakamura,A.,Oyanagi,K.,


講演・口頭発表等
完全閉じ込め状態に至った筋萎縮性側索硬化症患者の中枢体性感覚路の生理学的・放射線学的・病理学的検討
臨床神経生理学 44 5 400 2016(Oct.)
Presenter:清水俊夫, 林健太郎, 長尾雅裕, 中山優季, 望月葉子, 木田耕太, 小柳清光, 小森隆司, 川田明広, 磯崎英治


小脳失調を来たし、神経細胞胞体内ポリグルタミン顆粒を脳内に広範に認めた一剖検例
The Kitakanto Medical Journal 66 2 174-175 2016(May)
Presenter:小柳清光, 中原亜紗, 北澤邦彦, 吉田邦広, 岩谷舞, 佐野健司, 石川欽也, 山田光則


臨床的に視神経脊髄炎(NMO)と診断し脊髄と大脳中心灰白質に広汎な壊死性病変を認めた一剖検例
The Kitakanto Medical Journal 66 2 176 2016(May)
Presenter:宮平鷹揚, 武井洋一, 腰原啓史, 小口賢哉, 大原慎司, 菅野裕幸, 小柳清光, 柿田明美


家族歴があり、数年の経過で認知機能障害・歩行障害が進行した56歳女性脳生検例
諏訪赤十字医学雑誌 9 50-51 2016(Mar.)
Presenter:木下通亨, 池田修一, 小柳清光


完全閉じ込め状態にある筋萎縮性側索硬化症患者におけるSEPとVEPの乖離
臨床神経生理学 43 5 423 2015(Oct.)
Presenter:清水俊夫, 中山優季, 望月葉子, 林健太郎, 木田耕太, 木村英紀, 長尾雅裕, 川田明広, 磯崎英治, 小柳清光


クモ膜下出血と脊髄壊死を来した一剖検例
信州医学雑誌 63 1 69-70 2015(Feb.)
Presenter:中原亜紗, 橋本隆男, 樋口佳代子, 菅野祐幸, 小柳清光


MISC
疾患特異的蛋白はシナプスを越えるのか:筋萎縮性側索硬化症のTDP-43を中心に
細胞,50(6):336-339 2018
Author:小柳清光


白質に強い組織崩壊を呈し、皮質にも病変が及んだ進行性多巣性白質脳症(PML)の1例
信州医誌,60(1):55-56 2012
Author:木下通亨、永松清四郎、宍戸-原由紀子、池田修一、小柳清光


構音障害、運動失調、認知症状を呈し、胸髄クラーク柱神経細胞脱落と脳幹に多数のレビー小体とを呈したポリグルタミン免疫染色陽性85歳剖検例
信州医誌,60(1):52-53 2012
Author:小柳清光、山本寛二、保坂典子


臨床診断で苦慮した、脳マンソン孤虫症の1例
信州医誌,60(1):57-58 2012
Author:中川道隆、大野和幸、田澤浩一、池田修一、小柳清光、後藤哲哉、高本雅哉、吉澤明彦


神経病理入門 1.基本的な脳標本の作製法
Medical Technology,39(9):939-946 2011
Author:橋本智代、小柳清光