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牛木 淳人  ウシキ アツヒト

教員組織学術研究院(医学系(附属病院))電話番号0263-37-2631
教育組織医学部附属病院 医療情報部FAX番号0263-36-3722
職名准教授メールアドレスatsuhito@shinshu-u.ac.jp
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

更新日:2022/12/14

プロフィール

研究分野
呼吸器感染症
非結核性抗酸菌症
薬剤性肺障害
日和見感染症
キーワード:非結核性抗酸菌症 , 薬剤性間質性肺炎 , 日和見感染症
現在の研究課題
薬剤性間質性肺炎の臨床背景の検討
キーワード:薬剤性間質性肺炎 , 臨床背景
日和見感染症の臨床研究
キーワード:日和見感染症
所属学会
所属学会
日本医療情報学会
日本呼吸ケア・リハビリテーション学会
日本内科学会
日本呼吸器学会
日本感染症学会
日本呼吸器内視鏡学会
日本肺癌学会
日本結核・日結核性抗酸菌症学会
日本エイズ学会
日本化学療法学会
学歴
出身学校・専攻等(大学院を除く)
2002 , 信州大学医学部医学科

取得学位
博士 , 信州大学(日本)
研究職歴等
研究職歴
2015- , 信州大学医学部附属病院 呼吸器・感染症・アレルギー内科 講師
2014-2015 , 信州大学医学部附属病院 呼吸器・感染症内科 講師
2012-2014 , 信州大学医学部付属病院 呼吸器・感染症内科 助教
2011-2011 , 信州大学医学部付属病院 呼吸器・感染症内科 助教(特定雇用)
2010-2011 , 信州大学医学部附属病院呼吸器感染症内科 助教(診療)

研究活動業績

研究業績(著書・
発表論文等)
書籍等出版物
「一目瞭然!目で診る症例」解答, 日本内科学会雑誌 98 11, 2924-2925
日本内科学会 2009(Nov. 10)
Author:牛木 淳人,久保 惠嗣


論文
ニューモシスチス肺炎
呼吸器内科 = Respiratory medicine / 呼吸器内科編集委員会 編,41(3):256-261 2022(Mar.)
Author:牛木 淳人


Successful Rescue of Life-threatening Hemoptysis Caused by Pulmonary Tuberculosis Bridging with Extracorporeal Membrane Oxygenation: A Case Report
INTERNAL MEDICINE,advpub 2022
Author:Araki Taisuke;Uehara Naoya;Kamijo Hiroshi;Suzuki Yusuke;Komatsu Masamichi;Machida Ryosuke;Wada Yosuke;Ichiyama Takashi;Ushiki Atsuhito;Hanaoka Masayuki


Obstructive Pneumonia Associated with Endobronchial Aspergilloma: Successful Treatment with Interventional Bronchoscopy and Antifungals
INTERNAL MEDICINE,advpub 2022
Author:Komatsu Masamichi;Yasuo Masanori;Wada Yosuke;Takata Munetake;Azuhata Hisanori;Ikuyama Yuichi;Akahane Jumpei;Sonehara Kei;Ushiki Atsuhito;Yamamoto Hiroshi;Hanaoka Masayuki


The usefulness of a combination of age, body mass index, and blood urea nitrogen as prognostic factors in predicting oxygen requirements in patients with coronavirus disease 2019
JOURNAL OF INFECTION AND CHEMOTHERAPY,27(12):1706-1712 2021(Dec.)
Author:Goto, Norihiko; Wada, Yosuke; Ikuyama, Yuichi; Akahane, Jumpei; Kosaka, Makoto; Ushiki, Atsuhito; Kitaguchi, Yoshiaki; Yasuo, Masanori; Yamamoto, Hiroshi; Matsuo, Akemi; Hachiya, Tsutomu; Ideura, Gen; Yamazaki, Yoshitaka; Hanaoka, Masayuki;
Keywords:Aged; Body mass index; Blood urea nitrogen; COVID-19; Diabetes mellitus; Nomograms;


Blood urea nitrogen-to-serum albumin ratio and A-DROP are useful in assessing the severity of Pneumocystis pneumonia in patients without human immunodeficiency virus infection
JOURNAL OF INFECTION AND CHEMOTHERAPY,27(5):707-714 2021(May)
Author:Akahane, Jumpei; Ushiki, Atsuhito; Kosaka, Makoto; Ikuyama, Yuichi; Matsuo, Akemi; Hachiya, Tsutomu; Yoshiike, Fumiaki; Koyama, Shigeru; Hanaoka, Masayuki;
Keywords:Pneumocystis pneumonia; Prognostic factors; A-DROP; Blood urea nitrogen-to-serum albumin ratio;


Isolated splenic Mycobacterium tuberculosis complex infection in an immunocompetent individual with FDG-PET positive mass
JOURNAL OF INFECTION AND CHEMOTHERAPY,27(2):354-358 2021(Feb.)
Author:Nishina, Sayaka; Sakai, Hitoshi; Kawakami, Toru; Kanai, Shinichiro; Ushiki, Atsuhito; Natori, Tatsuya; Igarashi, Yuriko; Mitarai, Satoshi; Yoshiyama, Takashi; Ishida, Fumihiro; Nakazawa, Hideyuki;
Keywords:Mycobacterium tuberculosis complex; Extrapulmonary; Spleen; FDG-PET; IS6110;


Clinical characteristics of non-idiopathic pulmonary fibrosis, progressive fibrosing interstitial lung diseases A single-center retrospective study
MEDICINE,100(13):e25322 2021
Author:Komatsu, Masamichi; Yamamoto, Hiroshi; Kitaguchi, Yoshiaki; Kawakami, Satoshi; Matsushita, Mina; Uehara, Takeshi; Kinjo, Takumi; Wada, Yosuke; Ichiyama, Takashi; Urushihata, Kazuhisa; Ushiki, Atsuhito; Yasuo, Masanori; Hanaoka, Masayuki;
Keywords:idiopathic pulmonary fibrosis; interstitial lung disease; progressive fibrosing interstitial lung disease;


The utility of serum C-C chemokine ligand 1 in sarcoidosis: A comparison to IgG4-related disease (vol 133, 155123, 2020)
CYTOKINE,133:155171 2020(Sep.)
Author:Komatsu, Masamichi; Yamamoto, Hiroshi; Yasuo, Masanori; Ushiki, Atsuhito; Nakajima, Tomoyuki; Uehara, Takeshi; Kawakami, Satoshi; Hanaoka, Masayuki;


Association of HLA-DRB1*04:05 allele with drug-induced interstitial lung disease in Japanese population
PHARMACOGENOMICS JOURNAL,20(6):823-830 2020(May 28)
Author:Takuya Imatoh;Atsuhito Ushiki;Masao Ota;Michiko Ito;Akihiro Sekine;Taiki Yamashita;Yoichi Mashimo;Ryosuke Nakamura;Kosuke Saito;Yoshiro Saito;Masayuki Hanaoka


A comparison of the features of fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between IgG4-related disease with bilateral hilar lymphadenopathy and sarcoidosis
NAGOYA JOURNAL OF MEDICAL SCIENCE,82(1):101-111 2020(Feb.)
Author:Ozawa, Yoko; Yamamoto, Hiroshi; Yasuo, Masanori; Komatsu, Masamichi; Ushiki, Atsuhito; Hamano, Hideaki; Uehara, Takeshi; Kawakami, Satoshi; Fujita, Akira; Fujinaga, Yasunari; Oguchi, Kazuhiro; Kawa, Shigeyuki; Hanaoka, Masayuki;
Keywords:bilateral hilar lymphadenopathy (BHL); Fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET); Immunoglobulin G4-related disease (IgG4-RD); Sarcoidosis; maximum standardized uptake value (SUVmax);


Successful recovery from critical COVID-19 pneumonia with extracorporeal membrane oxygenation: A case report
Respiratory Medicine Case Reports,30:101113 2020
Author:Yuichi Ikuyama;Yosuke Wada;Kazunari Tateishi;Yoshiaki Kitaguchi;Masanori Yasuo;Atsuhito Ushiki;Kazuhisa Urushihata;Hiroshi Yamamoto;Hiroshi Kamijo;Atsuyoshi Mita;Hiroshi Imamura;Masayuki Hanaoka


Differences Between Central Airway Obstruction and Chronic Obstructive Pulmonary Disease Detected with the Forced Oscillation Technique
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,15:1425-1434 2020
Author:Yasuo, Masanori; Kitaguchi, Yoshiaki; Tokoro, Yayoi; Kosaka, Makoto; Wada, Yosuke; Kinjo, Takumi; Ushiki, Atsuhito; Yamamoto, Hiroshi; Hanaoka, Masayuki;
Keywords:forced oscillation technique; pulmonary function test; quality of life; central airway obstruction; COPD;


ペムブロリズマブ投与中に発症した水疱性類天疱瘡の1例
Skin Cancer,35(1):6-11 2020
Author:佐竹 宏介;諏訪 学;面高 俊和;佐藤 勇樹;三宅 知美;牛木 淳人;木庭 幸子;奥山 隆平


Prognosis of patients with acute exacerbation of combined pulmonary fibrosis and emphysema: a retrospective single-centre study
BMC PULMONARY MEDICINE,20(1):144 2020
Author:Ikuyama, Yuichi; Ushiki, Atsuhito; Kosaka, Makoto; Akahane, Jumpei; Mukai, Yuichi; Araki, Taisuke; Kitaguchi, Yoshiaki; Tateishi, Kazunari; Urushihata, Kazuhisa; Yasuo, Masanori; Yamamoto, Hiroshi; Hanaoka, Masayuki;
Keywords:Acute exacerbation; Combined pulmonary fibrosis and emphysema; Idiopathic pulmonary fibrosis; Prognosis; Emphysema;


原発不明癌による食道狭窄,気管食道瘻に対し気管ステント,食道ステントを留置し,経口摂取が可能となった1例
気管支学,42(2):188-192 2020
Author:生山 裕一;安尾 将法;曽根原 圭;平林 太郎;後藤 憲彦;野沢 修平;牛木 淳人;山本 洋;花岡 正幸


日本人の薬剤性肺障害 : 概論
呼吸器内科 = Respiratory medicine / 呼吸器内科編集委員会 編,36(6):597-603 2019(Dec.)
Author:牛木 淳人;ウシキ アツヒト;花岡 正幸;ハナオカ マサユキ


Probe-based optical fiberscopy for the direct observation of peripheral pulmonary lesions
Respiratory Investigation,57(5):481-489 2019(Sep.)
Author:Makoto Kosaka;Masanori Yasuo;Fumiya Kinota;Ryosuke Machida;Yoshiaki Kitaguchi;Atsuhito Ushiki;Hiroshi Yamamoto;Takeshi Uehara;Kazutoshi Hamanaka;Satoshi Kawakami;Masayuki Hanaoka


Comparison of the chemokine profiles in the bronchoalveolar lavage fluid between IgG4-related respiratory disease and sarcoidosis: CC-chemokine ligand 1 might be involved in the pathogenesis of sarcoidosis
CYTOKINE,120:125-129 2019(Aug.)
Author:Yamamoto, Hiroshi; Yasuo, Masanori; Komatsu, Masamichi; Ushiki, Atsuhito; Hamano, Hideaki; Hori, Atsushi; Nakajima, Tomoyuki; Uehara, Takeshi; Fujinaga, Yasunari; Matsui, Shoko; Hanaoka, Masayuki;
Keywords:Bronchoalveolar lavage; Chemokines; IgG4-related respiratory disease; Sarcoidosis; CC-chemokine ligand 1;


診断に難渋し外科的腹膜生検により診断した肺結核・結核性腹膜炎の1例
結核,94(2):45-50 2019(Feb.)
Author:荒木 太亮;アラキ タイスケ;岩波 直弥;イワナミ ナオヤ;濱 峰幸;ハマ ミネユキ;牛木 淳人;ウシキ アツヒト;山﨑 善隆;ヤマザキ ヨシタカ


Evaluation of respiratory airway impedance in patients with OSA during awakening
EUROPEAN RESPIRATORY JOURNAL,54 2019
Author:Machida, Ryosuke; Nozawa, Syuhei; Urushihata, Kazuhisa; Ushiki, Atsuhito; Yasuo, Masanori; Yamamoto, Hiroshi; Hanaoka, Masayuki;
Keywords:Apnoea / Hypopnea;


Twenty-year Follow-up of the First Bilateral Living-donor Lobar Lung Transplantation in Japan
INTERNAL MEDICINE,58(21):3133-3137 2019
Author:Komatsu, Masamichi; Yamamoto, Hiroshi; Shomura, Toshitaka; Sonehara, Kei; Ichiyama, Takashi; Urushihata, Kazuhisa; Ushiki, Atsuhito; Yasuo, Masanori; Wakamatsu, Toshihide; Sugimoto, Seiichiro; Oto, Takahiro; Date, Hiroshi; Koizumi, Tomonobu; Hanaoka, Masayuki; Kubo, Keishi;
Keywords:living-donor lobar lung transplantation; primary ciliary dyskinesia; cadaveric lung transplantation; long-term outcomes;


抗酸菌感染症(結核,非結核性抗酸菌症)について
信州医学雑誌,67(1):37-47 2019
Author:牛木 淳人


Virtual bronchoscopic navigation as an aid to CT-guided transbronchial biopsy improves the diagnostic yield for small peripheral pulmonary lesions
RESPIROLOGY,23(11):1049-1054 2018(Nov.)
Author:Kato, Akane; Yasuo, Masanori; Tokoro, Yayoi; Kobayashi, Takashi; Ichiyama, Takashi; Tateishi, Kazunari; Ushiki, Atsuhito; Urushihata, Kazuhisa; Yamamoto, Hiroshi; Hanaoka, Masayuki;
Keywords:bronchoscopy and interventional techniques; clinical trials; histology; cytology; lung cancer; radiology and other imaging;


CLINICAL PROGNOSIS OF ACUTE EXACERBATION OF COMBINED PULMONARY FIBROSIS AND EMPHYSEMA
RESPIROLOGY,23:272-272 2018(Nov.)
Author:Ikuyama, Yuichi; Ushiki, Atsuhito; Kosaka, Makoto; Jumpei, Akahane; Kitaguchi, Yoshiaki; Tateishi, Kazunari; Urushihata, Kazuhisa; Yasuo, Masanori; Yamamoto, Hiroshi; Hanaoka, Masayuki;


RISK FACTORS OF DISCONTINUATION OF MULTIPLE DRUGS TREATMENT OF MAC LUNG DISEASE
RESPIROLOGY,23:187-187 2018(Nov.)
Author:Ushiki, Atsuhito; Akahane, Junpei; Ikuyama, Yuichi; Kosaka, Makoto; Kitaguchi, Yoshiaki; Tateishi, Kazunari; Urushihata, Kazuhisa; Yasuo, Masanori; Yamamoto, Hiroshi; Hanaoka, Masayuki;


薬剤性肺障害の治療と予後,医薬品副作用被害救済制度 (特集 薬剤性肺障害 : 病態・診断・治療のUpdate)
最新醫學 = The medical frontline,73(7):905-909 2018(Jul.)
Author:牛木 淳人;ウシキ アツヒト;花岡 正幸;ハナオカ マサユキ


Usefulness of the forced oscillation technique in assessing the therapeutic result of tracheobronchial central airway obstruction
RESPIRATORY INVESTIGATION,56(3):222-229 2018(Mar.)
Author:Yasuo, Masanori;Kitaguchi, Yoshiaki;Kinota, Fumiya;Kosaka, Makoto;Urushihata, Kazuhisa;Ushiki, Atsuhito;Yamamoto, Hiroshi;Kawakami, Satoshi;Hanaoka, Masayuki
Abstract:Background: Pulmonary function tests (PFTs) comprise the traditional method for detecting central airway obstruction (CAO) and evaluating therapeutic effects, but are effort dependent. By contrast, the forced oscillation technique (FOT) is performed during tidal breathing in an effort-independent mode and is universally used to assess respiratory function in patients with chronic obstructive pulmonary disease (COPD) and asthma. We used the FOT to measure airway resistance and reactance in patients with CAO before and after interventional bronchoscopy and compared the results to data obtained using PFTs. Methods: Twelve patients with CAO were recruited from December 2013 to July 2016. The FOT, PFTs, chest computed tomography (CT), COPD Assessment Test (CAT), and the modified Medical Research Council (mMRC) dyspnea scale were employed before and after interventional bronchoscopy. The minimum airway cross-sectional area (MACSA) was calculated using a CT image calculator. Results: Of the 12 patients, 6 had tracheal obstruction and 6 had bronchial obstruction. All FOT measurements, except Delta XS, were significantly improved after interventional bronchoscopy in all cases. The significance of the improvement was greater with the FOT than PFTs. The MACSA, CAT, and mMRC dyspnea scale scores also significantly improved in all cases. Furthermore, only alteration of resistance at 20 Hz (R20) significantly correlated with the alteration of the MACSA after intervention. No significant correlations were found for PFTs. Conclusions: The FOT is suitable and convenient for assessing therapeutic results in patients with tracheobronchial CAO. The alteration of R20 is useful for estimating the airway dilation of CAO after interventional bronchoscopy. (C)2018 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.


Bevacizumab-induced tracheoesophageal fistula in a patient suffering from lung cancer with bulky subcarinal lymph node: a case report
NAGOYA JOURNAL OF MEDICAL SCIENCE,80(1):129-134 2018(Feb.)
Author:Nishie, Kenichi; Yasuo, Masanori; Kitaguchi, Yoshiaki; Kobayashi, Nobumitsu; Tateishi, Kazunari; Ushiki, Atsuhito; Urushihata, Kazuhisa; Yamamoto, Hiroshi; Ideura, Gen; Hanaoka, Masayuki;
Keywords:bevacizumab; non-small-cell lung cancer; tracheoesophageal fistula;


高周波スネアにより切除した気管支内神経鞘腫の1例
気管支学,40(3):206-210 2018
Author:曽根原 圭;安尾 将法;堀内 俊道;加藤 あかね;小林 信光;牛木 淳人;山本 洋;花岡 正幸


A Four-Center Retrospective Study of the Efficacy and Toxicity of Low-Dose Trimethoprim-Sulfamethoxazole for the Treatment of Pneumocystis Pneumonia in Patients without HIV Infection
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,61(12):e01173-17 2017(Dec.)
Author:Kosaka, Makoto; Ushiki, Atsuhito; Ikuyama, Yuichi; Hirai, Kazuya; Matsuo, Akemi; Hachiya, Tsutomu; Hanaoka, Masayuki;
Keywords:low dose; Pneumocystis pneumonia; renal impairment; trimethoprim-sulfamethoxazole;


Two patients with TAFRO syndrome exhibiting strikingly similar anterior mediastinal lesions with predominantly fat attenuation on chest computed tomography
RESPIRATORY INVESTIGATION,55(2):176-180 2017(Mar.)
Author:Yoko Ozawa;Hiroshi Yamamoto;Masanori Yasuo;Hidekazu Takahashi;Kazunari Tateishi;Atsuhito Ushiki;Satoshi Kawakami;Yasunari Fujinaga;Shiho Asaka;Kenji Sano;Hiroshi Takayama;Hiroshi Imamura;Masayuki Hanaoka


Associations between the distance covered in the incremental shuttle walk test and lung function and health status in patients with chronic obstructive pulmonary disease
RESPIRATORY INVESTIGATION,55(1):33-38 2017(Jan.)
Author:Ushiki, Atsuhito;Nozawa, Shuhei;Yasuo, Masanori;Urushihata, Kazuhisa;Yamamoto, Hiroshi;Hanaoka, Masayuki;Fujimoto, Keisaku
Abstract:Background: Field walk tests such as the incremental shuttle walk test (ISWT) are simple tests for assessing the degree of disability in individuals with chronic obstructive pulmonary disease (COPD). In the present study, the correlations between exercise performance in the ISWT, lung function, and health status were examined in patients with COPD of varying seventies. Methods: A retrospective examination of 277 COPD patients was performed using the ISWT and lung function tests along with assessment of health status using St. George's Respiratory Questionnaire (SGRQ). In addition, we assessed the correlations between the walking distance, lung function parameters, and SGRQ scores. Results: ISWT distances were poorly correlated with lung function parameters and SGRQ scores in mild COPD patients. In contrast, ISWT distances were significantly correlated with pulmonary function parameters, such as vital capacity (%predicted) and forced expiratory volume in one second, and SGRQ scores in moderate and severe COPD patients. Conclusions: The ISWT is more independent of health status and pulmonary function in patients with mild COPD compared to moderate or severe cases. Therefore, the exercise capacity of patients with mild COPD should be estimated by the ISWT. (C) 2016 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.


An Unusual Case of Multicentric Castleman's Disease, Complicated by Pleural Effusion
信州医学雑誌,65(1):51-56 2017
Author:NOZAWA Shuhei;YASUO Masanori;YAMAMOTO Hiroshi;HAMA Mineyuki;TATEISHI Kazunari;USHIKI Atsuhito;HANAOKA Masayuki


The Complete Remission of Acquired Immunodeficiency Syndrome-associated Isolated Central Nervous System Lymphomatoid Granulomatosis: A Case Report and Review of the Literature
INTERNAL MEDICINE,56(18):2497-2501 2017
Author:Kano, Yasuhiro; Kodaira, Minori; Ushiki, Atsuhito; Kosaka, Makoto; Yamada, Mitsunori; Shingu, Kunihiko; Nishihara, Hiroshi; Hanaoka, Masayuki; Sekijima, Yoshiki;
Keywords:lymphomatoid granulomatosis; central nervous system; acquired immunodeficiency syndrome; anti-retroviral therapy; Epstein-Barr virus;


Intractable Cutaneous Nontuberculous Mycobacteriosis (Mycobacterium abscessus) during Treatment for Systemic Lupus Erythematosus
INTERNAL MEDICINE,56(10):1253-1257 2017
Author:Kishida, Dai; Sato, Mitsuto; Kobayashi, Chinatsu; Ueno, Ken-ichi; Kinoshita, Tomomi; Kodaira, Minori; Shimojima, Yasuhiro; Ishii, Wataru; Ushiki, Atsuhito; Ikeda, Shu-ichi;
Keywords:Mycobacterium abscessus; systemic lupus erythematosus; cutaneous lesion; clarithromycin; resistance;


薬剤性肺障害の臨床像
呼吸器内科 = Respiratory medicine / 呼吸器内科編集委員会 編,30(4):330-335 2016(Oct.)
Author:牛木 淳人;ウシキ アツヒト;花岡 正幸;ハナオカ マサユキ


A case of pulmonary Mycobacterium avium infection in an immunocompetent patient who showed a huge consolidation with a high FDG uptake on PET/CT
Respiratory Medicine Case Reports,19:49-52 2016
Author:Akane Kato;Hiroshi Yamamoto;Mariko Ikeda;Kazunari Tateishi;Atsuhito Ushiki;Masanori Yasuo;Satoshi Kawakami;Shiho Asaka;Kazuhiro Oguchi;Masayuki Hanaoka


Cytokine profiles in the BAL fluid of IgG4-related respiratory disease compared with sarcoidosis
ERJ Open Research,1(2):00009-2015 2015(Oct.)
Author:Hiroshi Yamamoto;Masanori Yasuo;Takashi Ichiyama;Atsuhito Ushiki;Masayuki Hanaoka;Hideaki Hamano;Takeshi Uehara;Satoshi Kawakami;Shoko Matsui;Keishi Kubo


日本における薬剤性肺障害の臨床像 (特集 薬剤性肺障害のとらえ方)
月刊薬事 = The pharmaceuticals monthly,57(2):191-195 2015(Feb.)
Author:牛木 淳人;


気管支結核加療後,長期経過を経て気管支狭窄をきたした1例
気管支学,37(1):28-32 2015
Author:小松 雅宙;安尾 将法;濱 峰幸;立石 一成;伊東 理子;牛木 淳人;漆畑 一寿;山本 洋;花岡 正幸


Hypertrophic Pulmonary Osteoarthropathy in Anaplastic Lymphoma Kinase (ALK)-positive Lung Cancer
INTERNAL MEDICINE,54(16):2045-2049 2015
Author:Komatsu, Masamichi; Yasuo, Masanori; Kobayashi, Nobumitsu; Tateishi, Kazunari; Ushiki, Atsuhito; Urushihata, Kazuhisa; Yamamoto, Hiroshi; Hanaoka, Masayuki; Matoba, Hisanori; Honda, Takayuki; Ichikawa, Kosuke;
Keywords:non-small-cell lung cancer; hypertrophic pulmonary osteoarthropathy; anaplastic lymphoma kinase; vascular endothelial growth factor;


Late-onset Rejection of a Unilateral Donor Lung with Vascular C4d Deposition in Bilateral Living-donor Lobar Lung Transplantation: An Autopsy Case Report
INTERNAL MEDICINE,53(15):1645-1650 2014
Author:Yamamoto, Hiroshi; Yoshida, Kazuo; Koizumi, Tomonobu; Tokoro, Yayoi; Fukushima, Toshiro; Tateishi, Kazunari; Ushiki, Atsuhito; Yokoyama, Toshiki; Yasuo, Masanori; Urushihata, Kazuhisa; Hanaoka, Masayuki; Shingu, Kunihiko; Shimojo, Hisashi; Kanno, Hiroyuki; Yoshizawa, Akihiko; Kawakami, Satoshi; Miyagawa-Hayashino, Aya; Date, Hiroshi; Kubo, Keishi;
Keywords:idiopathic pulmonary arterial hypertension (IPAH); living-donor lobar lung transplantation (LDLLT); C4d; antibody-mediated lung rejection (AMR);


Pediatric Pulmonary Tuberculoma with a Solid Pulmonary Nodule Detected on Chest Computed Tomography
INTERNAL MEDICINE,53(8):913-916 2014
Author:Ushiki, Atsuhito; Yamazaki, Yoshitaka; Ideura, Gen; Shinbo, Takashi; Sugawara, Mariko; Hama, Mineyuki; Hanaoka, Masayuki;
Keywords:pulmonary tuberculosis; latent tuberculosis infection; interferon; gamma release assay; chest computed tomography;


Generalized pustulosis associated with disseminated Mycobacterium avium infection in a non-AIDS patient
EUROPEAN JOURNAL OF DERMATOLOGY,24(3):402-403 2014
Author:Asai, Yuko; Kiniwa, Yukiko; Okada, Nagisa; Futatsugi, Toshimasa; Ushiki, Atsuhito; Uhara, Hisashi; Okuyama, Ryuhei;


Comparison of Distance of 6-min Walk Test and the Incremental Shuttle Walk Test with Lung Function or Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
信州医学雑誌,61(2):57-64 2013
Author:USHIKI Atsuhito;FUJIMOTO Keisaku;ITO Michiko;YASUO Masanori;URUSHIHATA Kazuhisa;HANAOKA Masayuki;KUBO Keishi


Antimicrobial and anti-inflammatory effects of clarithromycin on Mycobacterium avium complex replication in cultured human bronchial epithelial cells
JOURNAL OF INFECTION AND CHEMOTHERAPY,18(5):683-688 2012(Oct.)
Author:Yamazaki, Yoshitaka; Ushiki, Atsuhito; Tanabe, Yoshinari; Koyama, Sekiya; Kubo, Keishi;
Keywords:MAC; IL-8; BEAS-2B cell;


重症呼吸器感染症に対するステロイド療法の位置づけ (特集 重症呼吸器感染症に対する集学的治療の方向性)
呼吸器内科 = Respiratory medicine / 呼吸器内科編集委員会 編,21(4):337-342 2012(Apr.)
Author:牛木 淳人; 山本 洋; 久保 惠嗣;


Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for the Diagnosis of Intrathoracic Lesions : Experience of a Single Academic Medical Center
信州医学雑誌,60(5):249-255 2012
Author:YASUO Masanori;HANAOKA Masayuki;TOKORO Yayoi;HORIUCHI Toshimichi;ITO Michiko;KOJIMA Kazushi;IKEGAWA Kayoko;USHIKI Atsuhito;YAMAMOTO Hiroshi;YOSHIZAWA Akihiko;HONDA Takayuki;KUBO Keishi
Abstract:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been recognized as a minimally-invasive and effective method for the diagnosis and nodal staging of lung cancer.
We describe our initial experience with this method, including diagnostic sensitivity, safety, importance of obtaining histological samples, and diagnostic pitfalls. We retrospectively studied 100 patients (108 consecutive procedures) with radiologically suspicious intrathoracic lesions who were investigated by EBUS-TBNA.
The procedures were performed between January 2005 and December 2011 at our institute. Adequate sampling value was 91.7%. Total diagnostic yield was 68.5% (74/108). In diagnosed subjects, malignancy and benign disease were identified in 68 and 6 cases, respectively. Diagnostic yield was relatively high in malignancy (88.3%), and poor in benign (19.4%). In the subgroup of malignant subjects, the diagnostic yield was higher in lung cancer (96.2%) than in other malignancies (72.0%) but, the difference disappeared if malignant lymphoma was excluded. No major complications were associated with the procedure.
EBUS-TBNA is useful in accessing the circumference of the central airway tumor for diagnosis. Compared with previous studies, the diagnostic yield of mediastinal lymphoma and benign lesions is worse in our laboratory. Adequate tissue sampling and preparation are needed for the definitive diagnosis of malignant lymphoma and benign lesions.


IgG4-Related Airway Involvement Which Developed in a Patient Receiving Corticosteroid Therapy for Autoimmune Pancreatitis
INTERNAL MEDICINE,50(24):3023-3026 2011
Author:Yamamoto, H; Yasuo, M; Nomura, Y; Agatsuma, T; Ushiki, A; Yokoyama, T; Urushihata, K; Hanaoka, M; Koizumi, T; Iwaya, M; Yoshizawa, A; Kawakami, S; Hamano, H; Kawa, S; Kubo, K
Keywords:airway involvement; bilateral hilar lymphadenopathy (BHL); lymphoplasmacytic; IgG4; autoimmune pancreatitis (AIP);


A Case of Organizing Pneumonia Induced by Tocilizumab
INTERNAL MEDICINE,50(19):2191-2193 2011
Author:Ikegawa, K; Hanaoka, M; Ushiki, A; Yamamoto, H; Kubo, K
Keywords:tocilizumab; drug-induced pneumonia; organizing pneumonia;


Bronchoscopic Microsampling for Bacterial Colony Counting in Relevant Lesions in Patients with Pulmonary Mycobacterium avium Complex Infection
INTERNAL MEDICINE,50(12):1287-1292 2011
Author:Ushiki Atsuhito,Yamazaki Yoshitaka,Koyama Sekiya,Tsushima Kenji,Yamamoto Hiroshi,Hanaoka Masayuki,Kubo Keishi
Keywords:non-tuberculous mycobacteriosis; Mycobacterium avium complex; bronchoscopic microsampling; endobronchial ultrasonography;


Acute Lung Injury with Alveolar Hemorrhage Due to a Novel Swine-Origin Influenza A (H1N1) Virus
INTERNAL MEDICINE,49(5):427-430 2010
Author:Yokoyama, Toshiki; Tsushima, Kenji; Ushiki, Atsuhito; Kobayashi, Nobumitsu; Urushihata, Kazuhisa; Koizumi, Tomonobu; Kubo, Keishi;
Keywords:influenza; H1N1; alveolar hemorrhage; acute lung injury;


エタネルセプト使用中に発症した間質性肺炎の1例
日本呼吸器学会雑誌,47(10):870-874 2009(Oct. 10)
Author:横山 俊樹;山本 洋;福嶋 敏郎;吾妻 俊彦;牛木 淳人;松原 美佳子;小林 孝至;田名部 毅;安尾 将法;漆畑 一寿;花岡 正幸;小泉 知展;藤本 圭作;久保 恵嗣


An AIDS patient with immune reconstitution inflammatory syndrome due to pulmonary Mycobacterium kansasii infection during antiretroviral therapy
JOURNAL OF INFECTION AND CHEMOTHERAPY,15(5):331-334 2009(Oct.)
Author:Ito, Michiko; Komatsu, Yoshimichi; Ushiki, Atsuhito; Yamazaki, Yoshitaka; Kubo, Keishi;
Keywords:HIV; Immune reconstitution inflammatory syndrome; Mycobacterium kansasii;


Salvage chemotherapy with amrubicin and platinum for relapsed thymic carcinoma - experience in six cases
JOURNAL OF THORACIC ONCOLOGY,4(9):S750-S750 2009(Sep.)
Author:Agatsuma, Toshihiko; Koizumi, Tomonobu; Ichiyama, Takashi; Yokoyama, Toshiki; Ushiki, Atsuhito; Komatsu, Yoshimichi; Yoshikawa, Sumiko; Kobayashi, Takashi; Tanabe, Tsuyoshi; Yamamoto, Hiroshi; Kubo, Keishi; Hachiya, Tsutomu;


Genetic Heterogeneity of EGFR Mutation in Pleomorphic Carcinoma of the Lung: Response to Gefitinib and Clinical Outcome
JAPANESE JOURNAL OF CLINICAL ONCOLOGY,39(4):267-270 2009(Apr.)
Author:Ushiki, Atsuhito; Koizumi, Tomonobu; Kobayashi, Nobumitsu; Kanda, Shintarou; Yasuo, Masanori; Yamamoto, Hiroshi; Kubo, Keishi; Aoyagi, Daiju; Nakayama, Jun;
Keywords:EGFR; T790M; pulmonary pleomorphic carcinoma;


長時間作用型気管支拡張薬にて加療中のCOPDに対する短時間作用型β2刺激薬のadd-on効果
日本呼吸ケア・リハビリテーション学会誌,19(1):64-70 2009
Author:藤本 圭作;牛木 淳人;小松 佳道;吾妻 俊彦;吉川 純子;久保 惠嗣


「一目瞭然!目で診る症例」
日本内科学会雑誌,98(11):2923-2925 2009
Author:牛木 淳人; 久保 惠嗣;


L-Carbocisteine reduces neutrophil elastase-induced mucin production
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY,167(2):214-216 2009
Author:Yasuo, Masanori; Fujimoto, Keisaku; Imamura, Hitomi; Ushiki, Atsuhito; Kanda, Shintaro; Tsushima, Kenji; Kubo, Hiroshi; Yamaya, Mutsuo; Kubo, Keishi;
Keywords:L-Carbocisteine; Human neutrophil elastase; Oxidative stress; Antioxidant; Mucin production;


Colonic Sarcoidosis Presenting Multiple Submucosal Tumor-Like Lesions
INTERNAL MEDICINE,48(20):1813-1816 2009
Author:Ushiki Atsuhito,Koizumi Tomonobu,Kubo Keishi,Suzawa Kenichi,Arakura Norikazu,Suzawa Hirokazu
Keywords:colon; sarcoidosis; submucosal tumor;


孤立性肺腫瘤陰影を呈しCA19-9が高値を示した非結核性抗酸菌症の1例
信州医学雑誌,56(6):365-370 2008
Author:中川 佐和子; 吾妻 俊彦; 横山 俊樹; 牛木 淳人; 田名部 毅; 安尾 将法; 山本 洋; 花岡 正幸; 小泉 知展; 藤本 圭作; 久保 惠嗣; 椎名 隆之; 近藤 竜一; 吉田 和夫; 浅野 功治; 山崎 善隆;


A Rare Case of a Tracheal Fibroepithelial Polyp Treated by an Endobronchial Resection
INTERNAL MEDICINE,47(19):1723-1726 2008
Author:Ushiki Atsuhito,Yasuo Masanori,Tanabe Tsuyoshi,Urushihata Kazuhisa,Yamamoto Hiroshi,Hanaoka Masayuki,Koizumi Tomonobu,Fujimoto Keisaku,Kubo Keishi,Yamazaki Yoshitaka,Asano Koji
Keywords:fibroepithelial polyp; tracheobronchial tumor; endobronchial resection; electrosurgical snare;


肺コクシジオイデス症の1例
日本呼吸器学会雑誌,45(2):180-184 2007(Feb. 10)
Author:南澤 綾子;降旗 兼行;牛木 淳人;若松 俊秀;小山 茂


講演・口頭発表等
P-453 gefitinib投与前後のEGFR遺伝子変異を検索しえた肺多形癌の1剖検例(分子標的治療4,第49回日本肺癌学会総会号)
肺癌 48 5 603 2008(Oct. 05)
Presenter:牛木 淳人,小泉 知展,小林 信光,吾妻 俊彦,安尾 将法,漆畑 一寿,山本 洋,花岡 正幸,藤本 圭作,久保 惠嗣,山崎 善隆


1. 人工透析中にカルボプラチンとエトポシドの併用療法を施行した肺小細胞癌の1例(第85回肺癌学会中部支部会)
肺癌 44 7 800 2004(Dec. 20)
Presenter:牛木 淳人,降旗 兼行,南澤 綾子,若松 俊秀,小山 茂


92) 重症心不全を呈する心サルコイドーシスに, 両室ペーシングを施行した一例(第189回日本循環器学会関東甲信越地方会)
Circulation journal : official journal of theJapanese Circulation Society 68 769 2004(Apr. 20)
Presenter:牛木 淳人,横関 整,矢崎 善一,花岡 健,甲斐 龍一,古樫 薫,内川 慎一郎,筒井 浩,木下 修,久保 恵嗣,小山 潤,今村 浩

研究費
科学研究費補助金(研究代表者)
2021 - 2023 , 薬剤性間質性肺炎のスコアリングシステムによる診断基準の構築とバイオマーカーの同定 , 基盤研究(C)
2015 - 2016 , 質量分析によるM.avium complexの同定および肺MAC症増悪因子の検討 , 若手研究(B)
研究諸活動
学術論文査読件数
日本内科学会

教育活動実績

授業等
前期 , ユニット講義(呼吸器)
前期 , ユニット講義(感染症)
通年 , 臨床実習