医学博士, 信州大学

ライフサイエンス, 生体医工学 , 生体医工学

ナノテク・材料, ナノバイオサイエンス , ナノバイオサイエンス

ライフサイエンス, 整形外科学 , 整形外科学

ライフサイエンス, 薬系化学、創薬科学 , 薬系化学、創薬科学

2015年
信州大学先鋭領域融合研究群バイオメディカル研究所　准教授

2013年
信州大学　医学部　講師

2012年
信州大学 医学部　助教

2009年 - 2011年
信州大学 カーボン科学研究所　助教

2007年 - 2009年
信州大学 医学部　助教

1998年 - 2000年
信州大学付属短期大学　非常勤講師

1995年 - 2007年
信州大学 医学部　助手

1993年 - 1995年
山梨医科大学 教務職員

2002年 - 2005年, オクラホマ大学ヘルスサイエンスセンター　アシスタントリサーチャー

1993年, 北里大学, 衛生学研究科, 臨床化学

1991年, 北里大学, 衛生学部, 衛生技術学科

Three-Dimensional Modeling with Osteoblast-like Cells under External Magnetic Field Conditions Using Magnetic Nano-Ferrite Particles for the Development of Cell-Derived Artificial Bone.
Ma C, Izumiya M, Nobuoka H, Ueno R, Mimura M, Ueda K, Ishida H, Tomotsune D, Johkura K, Yue F, Saito N, Haniu H.
Nanomaterials (Basel)., 14, 251, 2024年
責任著者

Pork Liver Decomposition Product May Improve Frontal Lobe Function in Humans-Open Trial.
Suzuki M, Sato I, Sato M, Iwasaki H, Saito T, Kimura M, Sako K, Maeda T, Haniu H, Tsukahara T, Matsuda Y.
Brain Sci, 14, 586, 2024年

Lysophospholipids transport across blood-brain barrier in an in vitro reconstruction model.
Tsukahara T, Sasaki M, Haniu H, Matsuda Y.
Biochem Biophys Res Commun., 676, 91-96, 2023年10月

Biocompatibility Evaluation of Carbon Nanohorns in Bone Tissues.
Ueda K, Ma C, Izumiya M, Kuroda C, Ishida H, Uemura T, Saito N, Aoki K, Haniu H.
Nanomaterials (Basel), 13(2), 244, 2023年01月

Lysophospholipids: A Potential Drug Candidates for Neurodegenerative Disorders.
Karaki T, Haniu H, Matsuda Y. Tsukahara T,
BIOMEDICINES, 10(12), 3126, 2022年12月

Lysophospholipids–potent candidates for brain food, protects neuronal cells against α-Synuclein aggregation.
Karaki T, Haniu H, Matsuda Y, Tsukahara T.
Biomed Pharmacother, 156, 113891, 2022年12月

Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes.
Saito N, Haniu H, Aoki K, Nishimura N, Uemura T.
Adv Sci (Weinh), 9(24), e2201214, 2022年08月

Current Methods in the Study of Nanomaterials for Bone Regeneration.
Tanaka M, Izumiya M, Haniu H, Ueda K, Ma C, Ueshiba K, Ideta H, Sobajima A, Uchiyama S, Takahashi J, Saito N.
Nanomaterials (Basel)., 12(7), 1195, 2022年04月

異分野融合を活かした特色あるバイオマテリアル研究を目指して.
馬闖, 上田勝也, 泉谷惇, 羽二生久夫.
信州医学雑誌, 70, 247-249, 2022年

リゾリン脂質経口摂取による神経変性疾患の新規創薬基盤開発.
塚原完, 唐木達哉, 羽二生久夫, 上芝洸貴, 松田佳和.
Medical Science Digest, 48, 47-49, 2022年

Biokinetic Evaluation of Contrast Media Loaded Carbon Nanotubes Using a Radiographic Device.
Takasaka M, Kobayashi S, Usui Y, Haniu H, Tsuruoka S, Aoki K, Saito N.
Toxics, 9(12), 331, 2021年12月

Antitumor Effect of Sclerostin against Osteosarcoma.
Ideta H, Yoshida K, Okamoto M, Sasaki J, Kito M, Aoki K, Yoshimura Y, Suzuki S, Tanaka A, Takazawa A, Haniu H, Uemura T, Takizawa T, Sobajima A, Kamanaka T, Takahashi J, Kato H, Saito N.
Cancers (Basel), 13, 6015, 2021年11月

The Combined Effects of Lysophospholipids against Lipopolysaccharide-induced Inflammation and Oxidative Stress in Microglial Cells.
Tsukahara T, Hara H, Haniu H, Matsuda Y.
J Oleo Sci., 70, 947-954, 2021年07月

Evaluation of MC3T3-E1 Cell Osteogenesis in Different Cell Culture Media
Izumiya M, Haniu M, Ueda K, Ishida H, Ma C, Ideta H, Sobajima A, Ueshiba K, Uemura T, Saito N, Haniu H.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14), 7752, 2021年07月
責任著者

Abundant oleoyl-lysophosphatidylethanolamine in brain stimulates neurite outgrowth and protects against glutamate toxicity in cultured cortical neurons.
69. Hisano K, Yoshida H, Kawase S, Mimura T, Haniu H, Tsukahara T, Kurihara T, Matsuda Y, Saito N, Uemura T.
J Biochem., 2021年04月

Isolated lymphatic vessel lumen perfusion system for assessing nanomaterial movements and nanomaterial-induced responses in lymphatic vessels.
Kuroda C, Ajima K, Ueda K, Sobajima A, Yoshida K, Kamanaka T, Sasaki J, Ishida H, Haniu H, Okamoto M, Aoki K. Kato H, Saito N.
Nano Today., 36(101018), 2021年02月

Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades.
Hisano K, Kawase S, Mimura T, Yoshida H, Yamada H, Haniu H, Tsukahara T, Kurihara T, Matsuda Y, Saito N, Uemura T.
Biochem Biophys Res Commun., 534, 179-185, 2021年01月

Multiwall Carbon Nanotube Composites as Artificial Joint Materials.
Sobajima A, Okihara T, Moriyama S, Nishimura N, Osawa T, Miyamae K, Haniu H, Aoki K, Tanaka M, Usui Y, Sako K, Kato H, Saito N.
ACS Biomater. Sci. Eng., 6, 7032-7040, 2020年12月

Oral administration of porcine liver decomposition product for 4 weeks enhances visual memory and delayed recall in healthy adults over 40 years of age: A randomized, double-blind, placebo-controlled study.
Matsuda Y, Haniu H, Tsukahara T, Uemura T, Inoue T, Sako KI, Kojima J, Mori T, Sato K.
Exp Gerontol., 141, 111064, 2020年11月

Therapeutic Potential of Porcine Liver Decomposition Product: New Insights and Perspectives for Microglia-Mediated Neuroinflammation in Neurodegenerative Diseases.
Tsukahara T, Haniu H, Uemura T, Matsuda Y.
Biomedicines., 8, 446, 2020年10月

Carbon nanotube-based biomaterials for orthopaedic applications.
Aoki K, Ogihara N, Tanaka M, Haniu H, Saito N.
J Mater Chem B., 8, 9227-9238, 2020年10月

Carbon fibers for treatment of cancer metastasis in bone.
Kamanaka T, Haniu H, Tanaka M, Takizawa T, Aoki K, Okamoto M, Sobajima A, Yoshida K, Ideta H, Mimura T, Ishida H, Ueda K, Uemura T, Kim JH, Kim YA, Kato H, Saito N.
RSC Adv., 10, 33071-33079, 2020年09月

Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro.
Tsukahara T, Haniu H, Uemura T, Matsuda Y.
Sci Rep., 10, 3748, 2020年

Anti-PD-1 antibody decreases tumor-infiltrating regulatory T cells.
Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Tanaka M, Aoki K, Uemura T, Kato H, Haniu H, Saito N.
BMC CANCER, 20, 25, 2020年

The Use of Electrospun Organic and Carbon Nanofibers in Bone Regeneration.
Aoki K, Haniu H, Kim YA, Saito N.
Nanomaterials (Basel)., 10, 562, 2020年

Applications of Carbon Nanotubes in Bone Regenerative Medicine.
Tanaka M, Aoki K, Haniu H, Kamanaka T, Takizawa T, Sobajima A, Yoshida K, Okamoto M, Kato H, Saito N.
Nanomaterials (Basel)., 10, 659, 2020年

Cellular Responses of Human Lymphatic Endothelial Cells to Carbon Nanomaterials.
Sano M, Izumiya M, Haniu H*, Ueda K, Konishi K, Ishida H, Kuroda C, Uemura T, Aoki K, Matsuda Y, Saito N.
Nanomaterials (Basel)., 10, 1374, 2020年

Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers.
Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Okano S, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Kito M, Aoki K, Uemura T, Haniu H, Kato H, Saito N.
Oncotargets Ther., 12, 2513-2518, 2019年

In Vitro and In Vivo Evaluation of Starfish Bone-Derived β-Tricalcium Phosphate as a Bone Substitute Material.
Ishida H, Haniu H, Takeuchi A, Ueda K, Sano M, Tanaka M, Takizawa T, Sobajima A, Kamanaka T, Saito N.
Materials (Basel)., 12, E1881, 2019年

Organ accumulation and carcinogenicity of highly dispersed multi-walled carbon nanotubes administered intravenously in transgenic rasH2 mice.
Sobajima A, Haniu H, Nomura H, Tanaka M, Takizawa T, Kamanaka T, Aoki K, Okamoto M, Yoshida K, Sasaki J, Ajima K, Kuroda C, Ishida H, Okano S, Ueda K, Kato H, Saito N.
Int J Nanomedicine., 14, 6465-80, 2019年

Different aggregation and shape characteristics of carbon materials affect biological responses in RAW264 cells
Kuroda Chika, Ueda Katsuya, Haniu Hisao, Ishida Haruka, Okano Satomi, Takizawa Takashi, Sobajima Atsushi, Kamanaka Takayuki, Yoshida Kazushige, Okamoto Masanori, Tsukahara Tamotsu, Matsuda Yoshikazu, Aoki Kaoru, Kato Hiroyuki, Saito Naoto
International Journal of Nanomedicine, 13, 6079-6088, 2018年10月05日

Titanium fiber plates for bone tissue repair.
Takizawa T, Nakayama N, Haniu H, Aoki K, Okamoto M, Nomura H, Tanaka M, Sobajima A, Yoshida K, Kamanaka T, Ajima K, Oishi A, Kuroda C, Ishida H, Okano S, Kobayashi S, Kato H, Saito N.
Adv Mater., 30, 1703608, 2018年

Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPARγ activation in human umbilical vein endothelial cells.
Tsukahara T, Yamagishi S, Matsuda Y, Haniu H.
Biomed Pharmacother., 106, 686-691, 2018年

The AGP-PPARγ axis promotes oxidative stress and diabetic endothelial cell dysfunction.
Tsukahara R, Haniu H, Matsuda Y, Tsukahara T.
Mol Cell Endocrinol., 473, 100-113, 2018年

Physico-Chemical, in vitro, and in vivo evaluation of a 3D unidirectional porous hydroxyapatite scaffold for bone regeneration.
Tanaka M, Haniu H,Kamanaka T,Takizawa T, Sobajima A, Yoshida K, Aoki K, Okamoto M, Kato H, Saito N.
Materials (Basel)., 10, 33, 2017年

A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler.
Tanaka M, Sato Y, Haniu H, Nomura H, Kobayashi S, Takanashi S, Okamoto M, Takizawa T, Aoki K, Usui Y, Oishi A, Kato H, Saito N.
PLOS ONE, 12, e0172601, 2017年

In Vitro and In Vivo Evaluation of a Three-Dimensional Porous Multi-Walled Carbon Nanotube Scaffold for Bone Regeneration.
Tanaka M, Sato Y, Zhang M, Haniu H, Okamoto M, Aoki K, Takizawa T, Yoshida K, Sobajima A, Kamanaka T, Kato H, Saito N.
Nanomaterials, 7, 46, 2017年

Lysophosphatidic acid signaling regulates the KLF9-PPARγ axis in human induced pluripotent stem cell-derived neurons.
Tsukahara T, Yamagishi S, Matsuda Y, Haniu H.
Biochem Biophys Res Commun., 491, 223-227, 2017年

Lysophospholipid-related diseases and PPARγ signaling pathway.
Tsukahara T, Matsuda Y, Haniu H.
Int J Mol Sci., 18, 2730, 2017年

ラットの空間認知記憶に及ぼすコリン塩化物長期摂取の影響.
井上俊夫, 松田佳和, 佐藤卓美, 櫻田誓, 羽二生久夫, 塚原完, 杉田和夫, 馬渕知子, 江水保, 佐藤和三郎.
医学と薬学, 73, 1009-1016, 2016年

ブタ肝臓分解物のヒト認知機能改善効果.
松田佳和, 羽二生久夫, 塚原完, 井上俊夫, 佐古兼一, 杉田和夫, 馬渕知子, 江水保, 佐藤和三郎.
医学と薬学, 73, 1057-1066, 2016年

Short-term treatment with a 2-carba analog of cyclic phosphatidic acid induces lowering of plasma cholesterol levels in ApoE-deficient mice.
Tsukahara T, Haniu H, Matsuda Y, Murakami-Murofushi K.
Biochem Biophys Res Commun., 473, 107-113, 2016年

The dispersion state of tangled multi-walled carbon nanotubes affects their cytotoxicity.
Kuroda C, Haniu H, Ajima K, Tanaka M, Sobajima A, Ishida H, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N.
Nanomaterials, 6, 2016年, 査読有り

An advanced in situ imaging method using heavy metal-doped hollow tubes to evaluate the biokinetics of carbon nanotubes in vivo
Kobayashi, Shinsuke; Tsuruoka, Shuji; Usui, Yuki; Haniu, Hisao; Aoki, Kaoru; Takanashi, Seiji; Okamoto, Masanori; Nomura, Hiroki; Tanaka, Manabu; Aiso, Shigetoshi; Saito, Misae; Kato, Hiroyuki; Saito, Naoto;
NPG Asia Materials, 7, 2015年07月

CYCLIC PHOSPHATIDIC ACID INDUCES G(0/)G(1) ARREST, INHIBITS AKT PHOSPHORYLATION, AND DOWNREGULATES CYCLIN D1 EXPRESSION IN COLORECTAL CANCER CELLS
Tsukahara, T; Haniu, H; Matsuda, Y
CELLULAR & MOLECULAR BIOLOGY LETTERS, 20(1), 38-47, 2015年03月

The Role of Autophagy as a Mechanism of Toxicity Induced by Multi-Walled Carbon Nanotubes in Human Lung Cells
Tsukahara, Tamotsu; Matsuda, Yoshikazu; Haniu, Hisao
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 16(1), 40-48, 2015年01月

Cyclic phosphatidic acid inhibits the secretion of vascular endothelial growth factor from diabetic human coronary artery endothelial cells through peroxisome proliferator-activated receptor gamma.
Tsukahara T, Tsukahara R, Haniu H, Matsuda Y, Murakami-Murofushi K.
Mol Cell Endocrinol., 412, 320-329, 2015年

Specific biological responses of the synovial membrane to carbon nanotubes
Nomura, Hiroki; Takanashi, Seiji; Tanaka, Manabu; Haniu, Hisao; Aoki, Kaoru; Okamoto, Masanori; Kobayashi, Shinsuke; Takizawa, Takashi; Usui, Yuki; Oishi, Ayumu; Kato, Hiroyuki; Saito, Naoto;
SCIENTIFIC REPORTS, 5, 2015年

Endocytosis of Multiwalled Carbon Nanotubes in Bronchial Epithelial and Mesothelial Cells
Maruyama, K; Haniu, H; Saito, N; Matsuda, Y; Tsukahara, T; Kobayashi, S; Tanaka, M; Aoki, K; Takanashi, S; Okamoto, M; Kato, H
BioMed Research International, 2015, 793186, 2015年

Two-Dimensional Gel-Based Protein Standardization Verified by Western Blot Analysis
Haniu, Hisao; Watanabe, Daisuke; Kawashima, Yusuke; Matsumoto, Hiroyuki
Methods in Molecular Biology, 1312, 473-479, 2015年

Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells
Haniu, H; Saito, N; Matsuda, Y; Tsukahara, T; Usui, Y; Maruyama, K; Takanashi, S; Aoki, K; Kobayashi, S; Nomura, H; Tanaka, M; Okamoto, M; Kato, H
International Journal of Nanomedicine, 9, 1979-1990, 2014年

Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells
Tsukahara, Ryoko; Haniu, Hisao; Matsuda, Yoshikazu; Tsukahara, Tamotsu
FEBS Open Bio, 4, 947-951, 2014年

Cyclic Phosphatidic Acid Inhibits Alkyl-Glycerophosphate-Induced Downregulation of Histone Deacetylase 2 Expression and Suppresses the Inflammatory Response in Human Coronary Artery Endothelial Cells
Tsukahara, Tamotsu; Haniu, Hisao; Matsuda, Yoshikazu
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 11(9), 955-961, 2014年

Cyclic Phosphatidic Acid Stimulates cAMP Production and Inhibits Growth in Human Colon Cancer Cells
Tsukahara, T; Matsuda, Y; Haniu, H
PLOS ONE, 8(11), e81139, 2013年11月

Highly purified, multi-wall carbon nanotubes induce light-chain 3B expression in human lung cells
Tsukahara Tamotsu, Matsuda Yoshikazu, Usui Yuki, Haniu Hisao
Biochemical and biophysical research communications, 440(2), 348-353, 2013年10月18日

Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response
Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Tsukahara, Tamotsu; Maruyama, Kayo; Usui, Yuki; Aoki, Kaoru; Takanashi, Seiji; Kobayashi, Shinsuke; Nomura, Hiroki; Okamoto, Masanori; Shimizu, Masayuki; Kato, Hiroyuki
Toxicology in Vitro, 27(6), 1679-1685, 2013年09月

PTB-associated splicing factor (PSF) is a PPARγ-binding protein and growth regulator of colon cancer cells.
Tsukahara T, Haniu H, Matsuda Y.
PLOS ONE, 8, e58749, 2013年

Effect of alkyl glycerophosphate on the activation of peroxisome proliferator-activated receptor gamma and glucose uptake in C2C12 cells.
Tsukahara T, Haniu H, Matsuda Y.
Biochem Biophys Res Commun., 433, 281-285, 2013年

PSF Knockdown Enhances Apoptosis via Downregulation of LC3B in Human Colon Cancer Cells
Tsukahara, T; Matsuda, Y; Haniu, H
BioMed Research International, 2013, 204973, 2013年

Two-dimensional gel electrophoresis: glass tube-based IEF followed by SDS-PAGE.
Matsumoto H, Haniu H, Kurien BT, Komori N.
Methods Mol Biol., 869, 267-273, 2012年

Lysophosphatidic Acid Stimulates MCP-1 Secretion From C2C12 Myocytes.
Tsukahara T, Haniu H.
ISRN Inflamm., 2012, 983420, 2012年

Carbon Nanotubes Innovate on Medical Technology.
Usui Y, Haniu H, Tsuruoka S, Saito N.
Med Chem., 2, 105, 2012年

Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts.
Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N.
Adv Mater., 24, 2176-2185, 2012年

Peroxisome proliferator-activated receptor gamma overexpression suppresses proliferation of human colon cancer cells.
Tsukahara T, Haniu H.
Biochem Biophys Res Commun., 424, 524-529, 2012年

Manufacturing Strategy for Multiwalled Carbon Nanotubes as a Biocompatible and Innovative Material
Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Nakamura, Koichi; Ishigaki, Norio; Tsukahara, Tamotsu; Kato, Hiroyuki
Journal of Nanotechnology, 2012, 937819, 2012年

Basic Potential of Carbon Nanotubes in Tissue Engineering Applications
Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Tsukahara, Tamotsu; Usui, Yuki; Narita, Nobuyo; Hara, Kazuo; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Takanashi, Seiji; Okamoto, Masanori; Kobayashi, Shinsuke; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki
Journal of Nanomaterials, 2012, 343747, 2012年

Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes.
Ogihara N, Usui Y, Aoki K, Shimizu M, Narita N, Hara K, Nakamura K, Ishigaki N, Takanashi S, Okamoto M, Kato H, Haniu H, Ogiwara N, Nakayama N, Taruta S, Saito N.
Nanomedicine (Lond)., 7, 981-993, 2012年

Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice.
Takanashi S, Hara K, Aoki K, Usui Y, Shimizu M, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Okamoto M, Kobayashi S, Kato H, Sano K, Nishimura N, Tsutsumi H, Machida K, Saito N.
Sci Rep., 2, 498, 2012年

Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines
Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Kim, Yoong-Ahm; Park, Chul Ki; Tsukahara, Tamotsu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki
International Journal of Nanomedicine, 6(1), 3487-3497, 2011年12月

Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses
Haniu, Hisao; Saito, Naoto;Matsuda, Yoshikazu; Kim, Yoong-Ahm; Park, Chul Ki; Tsukahara, Tamotsu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki
International Journal of Nanomedicine, 6(1), 3295-3307, 2011年12月

Toxicoproteomic evaluation of carbon nanomaterials in vitro
Haniu, Hisao; Matsuda, Yoshikazu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Okamoto, Masanori; Takanashi, Seiji; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki; Saito, Naoto
JOURNAL OF PROTEOMICS, 74(12), 2703-2712, 2011年11月

DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes
Haniu, Hisao; Tsukahara, Tamotsu; Matsuda, Yoshikazu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki; Saito, Naoto
International Journal of Nanomedicine, 6(1), 2689-2695, 2011年11月

Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells
Tsukahara, Tamotsu; Haniu, Hisao
Molecular and Cellular Biochemistry, 352(1-2), 57-63, 2011年06月

Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation
Tsukahara, Tamotsu; Haniu, Hisao
Biochemical and biophysical research communications, 406(4), 558-563, 2011年03月

The Application of Proteomics to PK-PD Modeling and Simulation.
Sako K, Haniu H, Hasegawa M, et al
J Bioequiv Availab, 2011, S2-002, 2011年

Application of carbon fibers to biomaterials: A new era of nano-level control of carbon fibers after 30-years of development
Saito, Naoto; Aoki, Kaoru; Usui, Yuki; Shimizu, Masayuki; Hara, Kazuo; Narita, Nobuyo; Ogihara, Nobuhide; Nakamura, Koichi; Ishigaki, Norio; Kato, Hiroyuki; Haniu, Hisao; Taruta, Seiichi; Kim, Yoong Ahm; Endo, Morinobu
CHEMICAL SOCIETY REVIEWS, 40(7), 3824-3834, 2011年

Evaluation of CNT toxicity in comparison to tattoo ink nanoparticles for use as a biomaterial.
Hara K, Kaoru Aoki K, Usui Y, Shimizu M, Narita N, Ogihara N, Nakamura K, Ishigaki N, Sano K, Haniu H, Kato H, Nishimura N, Kim YA, Taruta S, Saito N.
Mater Today., 14, 434-440, 2011年

Proteomics-based safety evaluation of multi-walled carbon nanotubes
Haniu, H; Matsuda, Y; Takeuchi, K; Kim, YA; Hayashi, T; Endo, M
Toxicology and Applied Pharmacology, 242(3), 256-262, 2010年02月

Effect of Lecithin: Cholesterol Acyltransferase on the Formation of Cross-linked Apolipoprotein AI.
Kurosaki Y, Ikeya H, Haniu H, et al
J Ana Bio-Sci, 33, 151-160, 2010年

Potential of a Novel Safety Evaluation of Nanomaterials Using a Proteomic Approach
Haniu,Hisao; Matsuda,Yoshikazu; Takeuchi,Kenji
Journal of health science, 55(3), 428-434, 2009年06月

Proteome Profiling of Vitreoretinal Diseases by Cluster Analysis.
Shitama, T; Hayashi, H; Noge, S; Uchio, E; Oshima, K; Haniu, H;Takemori, N; Komori, N; Matsumoto, H
Proteomics Clin Appl, 2, 1265-1280, 2008年

タンパク質発現軌跡地図
松本博行, 羽二生久夫, 武森 信暁, 小森直香
比較生理生化学, 25, 139-146, 2008年

比較生理生化学における共時態と通時態　プロテオミクトラジェクトリマッピングの意義.
松本博行, 羽二生久夫
比較生理生化学, 24, 73-76, 2007年

Role of systemic T-cells and histopathological aspects after subcutaneous implantation of various carbon nanotubes in mice
Koyama, S; Endo, M; Kim, YA; Hayashi, T; Yanagisawa, T; Osaka, K; Koyama, H; Haniu, H; Kuroiwa, N
Carbon, 44(6), 1079-1092, 2006年

Medical application of carbon-nanotube-fitted nanocomposites: The microcatheter
Koyama, S; Haniu, H; Osaka, K; Koyama, H; Kuroiwa, N; Endo, M; Kim, YA; Hayashi, T
SMALL, 2(12), 1406-1411, 2006年

Proteomic trajectory mapping of biological transformation: Application to developmental mouse retina
Haniu, H; Komori, N; Takemori, N; Singh, A; Ash, JD; Matsumoto, H
PROTEOMICS, 6(11), 3251-3261, 2006年

Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration.
Tanito, M; Haniu, H; Elliott,MH; Singh, AK; Matsumoto, H; Anderson, RE
Free Radic Biol Med, 41, 1847-1859, 2006年

Developmental proteomics of mouse retina.
Haniu, H; Singh, A; Komori, N; Ash, JD; Koyama, S; Matsumoto, H
INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE, 45, U318-U318, 2004年

Cell growing with activated carbon fivers - Significances of porous size
Koyama S, Haniu H, Takeichi T, Tanaka S, Yamaguchi Y, Konishi G, Koyama H
Mol Cryst Liq Cryst, 388, 173-176, 2002年

Inhibition of cell cycle and induction of apoptosis due to modified C60 on HL-60 promyelocytic leukemic cells and it's macrophage-like cells
Koyama S, Haniu H, Tanaka S, Yamaguchi Y, Konishi G, Koyama H
Mol Cryst Liq Cryst, 386, 21-24, 2002年

Different tissue reactions to activated carbon fivers - Pathological and immunological findings after subcutaneous implantation
Koyama S, Tanaka S, Yamaguchi Y, Haniu H, Konishi G, Koyama H
Mol Cryst Liq Cryst, 388, 109-115, 2002年

Presinusoidal vessels predominantly contract in response to norepinephrine, histamine, and KC1 in rabbit Liver
Shibamoto, T; Wang, HG; Miyahara, T; Tanaka, S; Haniu, H; Koyama, S
JOURNAL OF APPLIED PHYSIOLOGY, 87(4), 1404-1412, 1999年

Yoshixol(TR) inhibits B16 melanoma cell growth in vivo and induces apoptosis-like (quantum thermodynamic) cell death
Koyama, S; Tanaka, S; Haniu, H; Yamaguchi, Y; Motoyoshiya, J
GENERAL PHARMACOLOGY, 33(2), 161-172, 1999年

In vitro and in vivo antiturnor activity of Yoshixol(TR) against murine L1210 leukemic cells
Tanaka, S; Koyama, S; Haniu, H; Yamaguchi, Y; Motoyoshiya, J
GENERAL PHARMACOLOGY, 33(2), 179-186, 1999年

Effect of ONO-5046, a specific neutrophil elastase inhibitor, on the phorbol myristate acetate-induced injury in isolated dog lung
Wang, HG; Shibamoto, T; Miyahara, T; Haniu, H; Tanaka, S; Fujimoto, K; Honda, T; Kubo, K; Koyama, S
EXPERIMENTAL LUNG RESEARCH, 25(1), 55-67, 1999年

カーボンナノチューブ・グラフェンハンドブック
薄井雄企, 青木薫, 羽二生久夫　他
コロナ社, 282-289 2011年

In Advances in Medicine&Biology 11
Saito N, Aoki K, Usui Y, Shimizu M, Hara K, Narita N, Ogihara N, Nakamura K, Ishigaki N,Kato H, Haniu H, Kim C, Taruta S, Kim YA, Endo M., Thin Carbon Fiber Web that Functions as a Scaffold for Tissue Regeneration.
Nova Science Publishers Inc, 301-310 2011年

コメディカルによるバイタル異常・急変・ME機器でのアラームサインへのアプローチ
小野寺憲治 他
薬事日報社, 2010年

人体の働きと医薬品. 登録販売者標準テキスト
小野寺憲治,松田佳和　他
薬事日報社, 2010年

Bone Regeneration: Growth Factors, Augmentation Procedures and Tissue Engineering Applications
Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogihara N, Nakamura K, Ishigaki N, Kato H, Haniu H, Taruta S, Endo M., Application of carbon nanotubes on scaffolds for bone tissue regeneration.
Nova Science Publishers, 275-284 2010年

生理学
信州大学

2016年
日本バイオマテリアル学会

2012年 - 2018年
日本レギュラトリーサイエンス学会

2009年
日本プロテオーム学会

2009年
日本毒性学会

思春期特発性側弯症患者に対する後方矯正固定術に必要なスクリューの数の最適化
科学研究費補助金, 基盤研究（C)
2014年 - 2016年

多層カーボンナノチューブブロックを用いたin vitroでの骨形成再現実験
科学研究費補助金, 挑戦的萌芽研究
2014年 - 2015年

カーボンナノチューブによる骨芽細胞の石灰化促進メカニズムの解明
科学研究費補助金, 基盤研究（C)
2013年 - 2015年

ナノマテリアルに対する特異的受容体の同定
科学研究費補助金, 基盤研究（C)
2013年 - 2015年

環状ホスファチジン酸による抗動脈硬化作用を利用した治療創薬の基盤開発
科学研究費補助金, 基盤研究（B)
2013年 - 2015年

カーボンナノチューブとPEEK材を複合する技術を活用した脊椎手術のための高機能インプラントの開発
2012年

界面制御CNTコンポジット材料を用いた高機能人工関節の開発
2012年

ナノカーボン生体応用研究開発
共同研究
2007年 - 2011年

ＲＯＰマウス網膜のプロテオミクストラジェクトリの構築と毛細血管再形成機序の解明
科学研究費補助金, 基盤研究（Ｃ）
2007年 - 2008年

気相法カーボンナノチューブの選択成長とナノ構造制御ならびに機能評価に関する研究
科学研究費補助金, 特別推進研究
2007年 - 2008年

網膜血管新生におけるNDRG1の役割
2007年 - 2007年

ナノ構造評価・機能評価
共同研究
2006年 - 2006年

網膜血管の再生機序のプロテオミクスによる解析
共同研究
2006年 - 2006年

ナノマテリアルの安全性評価

ナノマテリアルの医療応用

培養細胞による人工骨の作製

脊髄損傷の治癒薬の開発