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羽二生久夫  ハニウ ヒサオ

教員組織学術研究院(医学系)電話番号0263-37-3555
教育組織先鋭領域融合研究群 バイオメディカル研究所 バイオテクノロジー・生体医工学部門FAX番号0263-37-3549
職名准教授メールアドレスhhaniu@shinshu-u.ac.jp
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

更新日:2019/08/09

プロフィール

研究分野
生体医工学・生体材料学
ナノバイオサイエンス
放射線・化学物質影響科学
環境影響評価
現在の研究課題
カーボンナノチューブの安全性評価
キーワード:カーボンナノチューブ , プロテオミクス , 細胞毒性 , 2005
所属学会
所属学会
日本バイオマテリアル学会
日本ヒトプロテオーム学会
日本トキシコロジー学会
日本レギュラトリーサイエンス学会
学歴
出身大学院
1993 , 北里大学 , 衛生学研究科 , 臨床化学

出身学校・専攻等(大学院を除く)
1991 , 北里大学 , 衛生学部 , 衛生技術学科

取得学位
医学博士 , 信州大学
研究職歴等
研究職歴
2015- , 信州大学先鋭領域融合研究群バイオメディカル研究所 准教授
2013- , 信州大学 医学部 講師
2012- , 信州大学 医学部 助教
2009-2011 , 信州大学 カーボン科学研究所 助教
2007-2009 , 信州大学 医学部 助教
1995-2007 , 信州大学 医学部 助手
1993-1995 , 山梨医科大学 教務職員

研究職歴以外の職歴
1998-2000 , 信州大学付属短期大学 非常勤講師

留学歴
2002-2005 , オクラホマ大学ヘルスサイエンスセンター アシスタントリサーチャー

研究活動業績

研究業績(著書・
発表論文等)
著書
Thin Carbon Fiber Web that Functions as a Scaffold for Tissue Regeneration.
Nova Science Publishers Inc , In Advances in Medicine&Biology , 11:301-310 2011
Author:Saito N, Aoki K, Usui Y, Shimizu M, Hara K, Narita N, Ogihara N, Nakamura K, Ishigaki N,Kato H, Haniu H, Kim C, Taruta S, Kim YA, Endo M.


カーボンナノチューブ・グラフェンハンドブック
コロナ社 , :282-289 2011
Author:薄井雄企, 青木薫, 羽二生久夫 他


Application of carbon nanotubes on scaffolds for bone tissue regeneration.
Nova Science Publishers , Bone Regeneration: Growth Factors, Augmentation Procedures and Tissue Engineering Applications , :275-284 2010
Author:Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogihara N, Nakamura K, Ishigaki N, Kato H, Haniu H, Taruta S, Endo M.


人体の働きと医薬品. 登録販売者標準テキスト
薬事日報社 2010
Author:小野寺憲治,松田佳和 他


コメディカルによるバイタル異常・急変・ME機器でのアラームサインへのアプローチ
薬事日報社 2010
Author:小野寺憲治 他


論文
Different aggregation and shape characteristics of carbon materials affect biological responses in RAW264 cells
INTERNATIONAL JOURNAL OF NANOMEDICINE,13:6079-6088 2018(Oct. 05)
Author:Kuroda Chika, Ueda Katsuya, Haniu Hisao, Ishida Haruka, Okano Satomi, Takizawa Takashi, Sobajima Atsushi, Kamanaka Takayuki, Yoshida Kazushige, Okamoto Masanori, Tsukahara Tamotsu, Matsuda Yoshikazu, Aoki Kaoru, Kato Hiroyuki, Saito Naoto


The AGP-PPARγ axis promotes oxidative stress and diabetic endothelial cell dysfunction.
Mol Cell Endocrinol.,473:100-113 2018
Author:Tsukahara R, Haniu H, Matsuda Y, Tsukahara T.


Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPARγ activation in human umbilical vein endothelial cells.
Biomed Pharmacother.,106:686-691 2018
Author:Tsukahara T, Yamagishi S, Matsuda Y, Haniu H.


Titanium fiber plates for bone tissue repair.
Adv Mater.,30:1703608 2018
Author:Takizawa T, Nakayama N, Haniu H, Aoki K, Okamoto M, Nomura H, Tanaka M, Sobajima A, Yoshida K, Kamanaka T, Ajima K, Oishi A, Kuroda C, Ishida H, Okano S, Kobayashi S, Kato H, Saito N.


Lysophospholipid-related diseases and PPARγ signaling pathway.
Int J Mol Sci.,18:2730 2017
Author:Tsukahara T, Matsuda Y, Haniu H.


Lysophosphatidic acid signaling regulates the KLF9-PPARγ axis in human induced pluripotent stem cell-derived neurons.
Biochem Biophys Res Commun.,491:223-227 2017
Author:Tsukahara T, Yamagishi S, Matsuda Y, Haniu H.


In Vitro and In Vivo Evaluation of a Three-Dimensional Porous Multi-Walled Carbon Nanotube Scaffold for Bone Regeneration.
Nanomaterials,7:46 2017
Author:Tanaka M, Sato Y, Zhang M, Haniu H, Okamoto M, Aoki K, Takizawa T, Yoshida K, Sobajima A, Kamanaka T, Kato H, Saito N.


A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler.
PLoS One,12:e0172601 2017
Author:Tanaka M, Sato Y, Haniu H, Nomura H, Kobayashi S, Takanashi S, Okamoto M, Takizawa T, Aoki K, Usui Y, Oishi A, Kato H, Saito N.


Physico-Chemical, in vitro, and in vivo evaluation of a 3D unidirectional porous hydroxyapatite scaffold for bone regeneration.
Materials,10:33 2017
Author:Tanaka M, Haniu H,Kamanaka T,Takizawa T, Sobajima A, Yoshida K, Aoki K, Okamoto M, Kato H, Saito N.


ブタ肝臓分解物のヒト認知機能改善効果.
医学と薬学,73:1057-1066 2016
Author:松田佳和, 羽二生久夫, 塚原完, 井上俊夫, 佐古兼一, 杉田和夫, 馬渕知子, 江水保, 佐藤和三郎.


ラットの空間認知記憶に及ぼすコリン塩化物長期摂取の影響.
医学と薬学,73:1009-1016 2016
Author:井上俊夫, 松田佳和, 佐藤卓美, 櫻田誓, 羽二生久夫, 塚原完, 杉田和夫, 馬渕知子, 江水保, 佐藤和三郎.


The dispersion state of tangled multi-walled carbon nanotubes affects their cytotoxicity.
Nanomaterials,6 2016
Author:Kuroda C, Haniu H, Ajima K, Tanaka M, Sobajima A, Ishida H, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N.


Short-term treatment with a 2-carba analog of cyclic phosphatidic acid induces lowering of plasma cholesterol levels in ApoE-deficient mice.
Biochem Biophys Res Commun.,473:107-113 2016
Author:Tsukahara T, Haniu H, Matsuda Y, Murakami-Murofushi K.


An advanced in situ imaging method using heavy metal-doped hollow tubes to evaluate the biokinetics of carbon nanotubes in vivo
NPG ASIA MATERIALS,7:- 2015(Jul.)
Author:Kobayashi, Shinsuke; Tsuruoka, Shuji; Usui, Yuki; Haniu, Hisao; Aoki, Kaoru; Takanashi, Seiji; Okamoto, Masanori; Nomura, Hiroki; Tanaka, Manabu; Aiso, Shigetoshi; Saito, Misae; Kato, Hiroyuki; Saito, Naoto;


CYCLIC PHOSPHATIDIC ACID INDUCES G(0/)G(1) ARREST, INHIBITS AKT PHOSPHORYLATION, AND DOWNREGULATES CYCLIN D1 EXPRESSION IN COLORECTAL CANCER CELLS
CELLULAR & MOLECULAR BIOLOGY LETTERS,20(1):38-47 2015(Mar.)
Author:Tsukahara, T; Haniu, H; Matsuda, Y


The Role of Autophagy as a Mechanism of Toxicity Induced by Multi-Walled Carbon Nanotubes in Human Lung Cells
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,16(1):40-48 2015(Jan.)
Author:Tsukahara, Tamotsu; Matsuda, Yoshikazu; Haniu, Hisao


Cyclic phosphatidic acid inhibits the secretion of vascular endothelial growth factor from diabetic human coronary artery endothelial cells through peroxisome proliferator-activated receptor gamma.
Mol Cell Endocrinol.,412:320-329 2015
Author:Tsukahara T, Tsukahara R, Haniu H, Matsuda Y, Murakami-Murofushi K.


Specific biological responses of the synovial membrane to carbon nanotubes
SCIENTIFIC REPORTS,5:- 2015
Author:Nomura, Hiroki; Takanashi, Seiji; Tanaka, Manabu; Haniu, Hisao; Aoki, Kaoru; Okamoto, Masanori; Kobayashi, Shinsuke; Takizawa, Takashi; Usui, Yuki; Oishi, Ayumu; Kato, Hiroyuki; Saito, Naoto;


Two-Dimensional Gel-Based Protein Standardization Verified by Western Blot Analysis
Methods in Molecular Biology ,1312:473-479 2015
Author:Haniu, Hisao; Watanabe, Daisuke; Kawashima, Yusuke; Matsumoto, Hiroyuki


Endocytosis of Multiwalled Carbon Nanotubes in Bronchial Epithelial and Mesothelial Cells
BIOMED RESEARCH INTERNATIONAL,2015:793186 2015
Author:Maruyama, K; Haniu, H; Saito, N; Matsuda, Y; Tsukahara, T; Kobayashi, S; Tanaka, M; Aoki, K; Takanashi, S; Okamoto, M; Kato, H


Cyclic Phosphatidic Acid Inhibits Alkyl-Glycerophosphate-Induced Downregulation of Histone Deacetylase 2 Expression and Suppresses the Inflammatory Response in Human Coronary Artery Endothelial Cells
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES,11(9):955-961 2014
Author:Tsukahara, Tamotsu; Haniu, Hisao; Matsuda, Yoshikazu


Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells
FEBS OPEN BIO,4:947-951 2014
Author:Tsukahara, Ryoko; Haniu, Hisao; Matsuda, Yoshikazu; Tsukahara, Tamotsu


Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells
INTERNATIONAL JOURNAL OF NANOMEDICINE,9:1979-1990 2014
Author:Haniu, H; Saito, N; Matsuda, Y; Tsukahara, T; Usui, Y; Maruyama, K; Takanashi, S; Aoki, K; Kobayashi, S; Nomura, H; Tanaka, M; Okamoto, M; Kato, H


Cyclic Phosphatidic Acid Stimulates cAMP Production and Inhibits Growth in Human Colon Cancer Cells
PLOS ONE,8(11):e81139 2013(Nov.)
Author:Tsukahara, T; Matsuda, Y; Haniu, H


Highly purified, multi-wall carbon nanotubes induce light-chain 3B expression in human lung cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,440(2):348-353 2013(Oct. 18)
Author:Tsukahara Tamotsu, Matsuda Yoshikazu, Usui Yuki, Haniu Hisao


Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response
Toxicology in Vitro,27(6):1679-1685 2013(Sep.)
Author:Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Tsukahara, Tamotsu; Maruyama, Kayo; Usui, Yuki; Aoki, Kaoru; Takanashi, Seiji; Kobayashi, Shinsuke; Nomura, Hiroki; Okamoto, Masanori; Shimizu, Masayuki; Kato, Hiroyuki


PSF Knockdown Enhances Apoptosis via Downregulation of LC3B in Human Colon Cancer Cells
BIOMED RESEARCH INTERNATIONAL,2013:204973 2013
Author:Tsukahara, T; Matsuda, Y; Haniu, H


Effect of alkyl glycerophosphate on the activation of peroxisome proliferator-activated receptor gamma and glucose uptake in C2C12 cells.
Biochem Biophys Res Commun.,433:281-285 2013
Author:Tsukahara T, Haniu H, Matsuda Y.


PTB-associated splicing factor (PSF) is a PPARγ-binding protein and growth regulator of colon cancer cells.
PLoS One,8:e58749 2013
Author:Tsukahara T, Haniu H, Matsuda Y.


Carbon Nanotubes Innovate on Medical Technology.
Med Chem.,2:105 2012
Author:Usui Y, Haniu H, Tsuruoka S, Saito N.


Lysophosphatidic Acid Stimulates MCP-1 Secretion From C2C12 Myocytes.
ISRN Inflamm.,2012:983420 2012
Author:Tsukahara T, Haniu H.


Peroxisome proliferator-activated receptor gamma overexpression suppresses proliferation of human colon cancer cells.
Biochem Biophys Res Commun.,424:524-529 2012
Author:Tsukahara T, Haniu H.


Two-dimensional gel electrophoresis: glass tube-based IEF followed by SDS-PAGE.
Methods Mol Biol.,869:267-273 2012
Author:Matsumoto H, Haniu H, Kurien BT, Komori N.


Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice.
Sci Rep.,2:498 2012
Author:Takanashi S, Hara K, Aoki K, Usui Y, Shimizu M, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Okamoto M, Kobayashi S, Kato H, Sano K, Nishimura N, Tsutsumi H, Machida K, Saito N.


Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts.
Adv Mater.,24:2176-2185 2012
Author:Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N.


Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes.
Nanomedicine (Lond).,7:981-993 2012
Author:Ogihara N, Usui Y, Aoki K, Shimizu M, Narita N, Hara K, Nakamura K, Ishigaki N, Takanashi S, Okamoto M, Kato H, Haniu H, Ogiwara N, Nakayama N, Taruta S, Saito N.


Basic Potential of Carbon Nanotubes in Tissue Engineering Applications
Journal of Nanomaterials,2012:343747 2012
Author:Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Tsukahara, Tamotsu; Usui, Yuki; Narita, Nobuyo; Hara, Kazuo; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Takanashi, Seiji; Okamoto, Masanori; Kobayashi, Shinsuke; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki


Manufacturing Strategy for Multiwalled Carbon Nanotubes as a Biocompatible and Innovative Material
Journal of Nanotechnology,2012:937819 2012
Author:Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Nakamura, Koichi; Ishigaki, Norio; Tsukahara, Tamotsu; Kato, Hiroyuki


Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines
International Journal of Nanomedicine,6(1):3487-3497 2011(Dec.)
Author:Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Kim, Yoong-Ahm; Park, Chul Ki; Tsukahara, Tamotsu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki


Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses
International Journal of Nanomedicine,6(1):3295-3307 2011(Dec.)
Author:Haniu, Hisao; Saito, Naoto;Matsuda, Yoshikazu; Kim, Yoong-Ahm; Park, Chul Ki; Tsukahara, Tamotsu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki


DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes
International Journal of Nanomedicine,6(1):2689-2695 2011(Nov.)
Author:Haniu, Hisao; Tsukahara, Tamotsu; Matsuda, Yoshikazu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki; Saito, Naoto


Toxicoproteomic evaluation of carbon nanomaterials in vitro
Journal of Proteomics,74(12):2703-2712 2011(Nov.)
Author:Haniu, Hisao; Matsuda, Yoshikazu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Okamoto, Masanori; Takanashi, Seiji; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki; Saito, Naoto


Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells
Molecular and Cellular Biochemistry,352(1-2):57-63 2011(Jun.)
Author:Tsukahara, Tamotsu; Haniu, Hisao


Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,406(4):558-563 2011(Mar.)
Author:Tsukahara, Tamotsu; Haniu, Hisao


Evaluation of CNT toxicity in comparison to tattoo ink nanoparticles for use as a biomaterial.
Mater Today.,14:434-440 2011
Author:Hara K, Kaoru Aoki K, Usui Y, Shimizu M, Narita N, Ogihara N, Nakamura K, Ishigaki N, Sano K, Haniu H, Kato H, Nishimura N, Kim YA, Taruta S, Saito N.


The Application of Proteomics to PK-PD Modeling and Simulation.
J Bioequiv Availab,2011:S2-002 2011
Author:Sako K, Haniu H, Hasegawa M, et al


Application of carbon fibers to biomaterials: A new era of nano-level control of carbon fibers after 30-years of development
CHEMICAL SOCIETY REVIEWS,40(7):3824-3834 2011
Author:Saito, Naoto; Aoki, Kaoru; Usui, Yuki; Shimizu, Masayuki; Hara, Kazuo; Narita, Nobuyo; Ogihara, Nobuhide; Nakamura, Koichi; Ishigaki, Norio; Kato, Hiroyuki; Haniu, Hisao; Taruta, Seiichi; Kim, Yoong Ahm; Endo, Morinobu


Proteomics-based safety evaluation of multi-walled carbon nanotubes
Toxicology and Applied Pharmacology,242(3):256-262 2010(Feb.)
Author:Haniu, H; Matsuda, Y; Takeuchi, K; Kim, YA; Hayashi, T; Endo, M


Effect of Lecithin: Cholesterol Acyltransferase on the Formation of Cross-linked Apolipoprotein AI.
J Ana Bio-Sci,33:151-160 2010
Author:Kurosaki Y, Ikeya H, Haniu H, et al


Potential of a Novel Safety Evaluation of Nanomaterials Using a Proteomic Approach
Journal of health science,55(3):428-434 2009(Jun.)
Author:Haniu,Hisao; Matsuda,Yoshikazu; Takeuchi,Kenji


タンパク質発現軌跡地図
比較生理生化学,25:139-146 2008
Author:松本博行, 羽二生久夫, 武森 信暁, 小森直香


Proteome Profiling of Vitreoretinal Diseases by Cluster Analysis.
Proteomics Clin Appl,2:1265-1280 2008
Author:Shitama, T; Hayashi, H; Noge, S; Uchio, E; Oshima, K; Haniu, H;Takemori, N; Komori, N; Matsumoto, H


比較生理生化学における共時態と通時態 プロテオミクトラジェクトリマッピングの意義.
比較生理生化学,24:73-76 2007
Author:松本博行, 羽二生久夫


Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration.
Free Radic Biol Med,41:1847-1859 2006
Author:Tanito, M; Haniu, H; Elliott,MH; Singh, AK; Matsumoto, H; Anderson, RE


Role of systemic T-cells and histopathological aspects after subcutaneous implantation of various carbon nanotubes in mice
CARBON,44(6):1079-1092 2006
Author:Koyama, S; Endo, M; Kim, YA; Hayashi, T; Yanagisawa, T; Osaka, K; Koyama, H; Haniu, H; Kuroiwa, N


Proteomic trajectory mapping of biological transformation: Application to developmental mouse retina
PROTEOMICS,6(11):3251-3261 2006
Author:Haniu, H; Komori, N; Takemori, N; Singh, A; Ash, JD; Matsumoto, H


Medical application of carbon-nanotube-fitted nanocomposites: The microcatheter
SMALL,2(12):1406-1411 2006
Author:Koyama, S; Haniu, H; Osaka, K; Koyama, H; Kuroiwa, N; Endo, M; Kim, YA; Hayashi, T


Developmental proteomics of mouse retina.
INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE,45:U318-U318 2004
Author:Haniu, H; Singh, A; Komori, N; Ash, JD; Koyama, S; Matsumoto, H


Different tissue reactions to activated carbon fivers - Pathological and immunological findings after subcutaneous implantation
Mol Cryst Liq Cryst,388:109-115 2002
Author:Koyama S, Tanaka S, Yamaguchi Y, Haniu H, Konishi G, Koyama H


Inhibition of cell cycle and induction of apoptosis due to modified C60 on HL-60 promyelocytic leukemic cells and it's macrophage-like cells
Mol Cryst Liq Cryst,386:21-24 2002
Author:Koyama S, Haniu H, Tanaka S, Yamaguchi Y, Konishi G, Koyama H


Cell growing with activated carbon fivers - Significances of porous size
Mol Cryst Liq Cryst,388:173-176 2002
Author:Koyama S, Haniu H, Takeichi T, Tanaka S, Yamaguchi Y, Konishi G, Koyama H


Effect of ONO-5046, a specific neutrophil elastase inhibitor, on the phorbol myristate acetate-induced injury in isolated dog lung
EXPERIMENTAL LUNG RESEARCH,25(1):55-67 1999
Author:Wang, HG; Shibamoto, T; Miyahara, T; Haniu, H; Tanaka, S; Fujimoto, K; Honda, T; Kubo, K; Koyama, S


In vitro and in vivo antiturnor activity of Yoshixol(TR) against murine L1210 leukemic cells
GENERAL PHARMACOLOGY,33(2):179-186 1999
Author:Tanaka, S; Koyama, S; Haniu, H; Yamaguchi, Y; Motoyoshiya, J


Yoshixol(TR) inhibits B16 melanoma cell growth in vivo and induces apoptosis-like (quantum thermodynamic) cell death
GENERAL PHARMACOLOGY,33(2):161-172 1999
Author:Koyama, S; Tanaka, S; Haniu, H; Yamaguchi, Y; Motoyoshiya, J


Presinusoidal vessels predominantly contract in response to norepinephrine, histamine, and KC1 in rabbit Liver
JOURNAL OF APPLIED PHYSIOLOGY,87(4):1404-1412 1999
Author:Shibamoto, T; Wang, HG; Miyahara, T; Tanaka, S; Haniu, H; Koyama, S

共同研究等希望テーマ
プロテオミクスを用いたナノマテリアルの新規安全性評価法の開発 , 毒性学
プロテオミクスを用いたナノマテリアルの品質管理法の開発 , 毒性学
研究費
共同研究
2007 - 2011 , ナノカーボン生体応用研究開発
2006 - 2006 , ナノ構造評価・機能評価
2006 - 2006 , 網膜血管の再生機序のプロテオミクスによる解析

科学研究費補助金(研究代表者)
2013 - 2015 , カーボンナノチューブによる骨芽細胞の石灰化促進メカニズムの解明 , 基盤研究(C)
2007 - 2008 , ROPマウス網膜のプロテオミクストラジェクトリの構築と毛細血管再形成機序の解明 , 基盤研究(C)

科学研究費補助金(研究分担者)
2014 - 2016 , 思春期特発性側弯症患者に対する後方矯正固定術に必要なスクリューの数の最適化 , 基盤研究(C)
2014 - 2015 , 多層カーボンナノチューブブロックを用いたin vitroでの骨形成再現実験 , 挑戦的萌芽研究
2013 - 2015 , ナノマテリアルに対する特異的受容体の同定 , 基盤研究(C)
2013 - 2015 , 環状ホスファチジン酸による抗動脈硬化作用を利用した治療創薬の基盤開発 , 基盤研究(B)
2007 - 2008 , 気相法カーボンナノチューブの選択成長とナノ構造制御ならびに機能評価に関する研究 , 特別推進研究

その他公的資金
2012 - , カーボンナノチューブとPEEK材を複合する技術を活用した脊椎手術のための高機能インプラントの開発
2012 - , 界面制御CNTコンポジット材料を用いた高機能人工関節の開発
2007 - 2007 , 網膜血管新生におけるNDRG1の役割

教育活動実績

授業等
2002 , 生理学