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上原剛  ウエハラ タケシ

教員組織学術研究院(医学系)電話番号0263-37-2805
教育組織医学部 医学科 病態解析診断学FAX番号0263-34-5316
職名准教授メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

更新日:2019/08/30

プロフィール

研究分野
人体病理学
病態検査学
現在の研究課題
消化管腫瘍の発癌
キーワード:診断病理
IgG4関連疾患の病理
キーワード:診断病理
所属学会
所属学会
日本病理学会
日本臨床細胞学会
日本臨床検査医学会
日本消化器病学会
日本膵臓学会
日本乳癌学会
国際病理アカデミー日本支部

所属学会役職担当
日本病理学会 , 学術評議員
日本臨床細胞学会 , 評議員
日本臨床検査医学会 , 評議員
学歴
出身学校・専攻等(大学院を除く)
1997 , 信州大学

取得学位
博士(医学) , 信州大学

免許・資格等
200409 , 検査専門医
200207 , 病理専門医
受賞学術賞
2014 , ホクト生物科学振興財団 平成26年度研究奨励賞
2004 , 長尾武難病研究基金
研究職歴等
研究職歴
2014- , 信州大学(医学部) 准教授
2009- , 信州大学(医学部) 講師
2005- , 信州大学(医学部) 助教

留学歴
2010-2012 , ペンシルバニア大学 客員講師

研究活動業績

研究業績(著書・
発表論文等)
著書
IgG4-Related Kidney Disease, Other Urogenital Lesions (Testis, Paratesticular Lesion, Bladder, Prostate etc.)
Springer 2016
Author:Takeshi Uehara, Yasunari Fujinaga, Teruyuki Ogawa, Shigeyuki Kawa


Molecular Pathology of Neoplastic Gastrointestinal Diseases, 10. Molecular Pathology of Inflammatory Bowel Disease Associated Neoplasia
Springer 2013
Author:Takeshi Uehara, Deqin Ma, and Antonia R. Sepulveda


論文
Comparison of the chemokine profiles in the bronchoalveolar lavage fluid between IgG4-related respiratory disease and sarcoidosis: CC-chemokine ligand 1 might be involved in the pathogenesis of sarcoidosis
CYTOKINE,120:125-129 2019(Aug.)
Author:Yamamoto, Hiroshi; Yasuo, Masanori; Komatsu, Masamichi; Ushiki, Atsuhito; Hamano, Hideaki; Hori, Atsushi; Nakajima, Tomoyuki; Uehara, Takeshi; Fujinaga, Yasunari; Matsui, Shoko; Hanaoka, Masayuki;


Correlation of clinicopathological features and LGR5 expression in colon adenocarcinoma
ANNALS OF DIAGNOSTIC PATHOLOGY,40:161-165 2019(Jun.)
Author:Sato, Koichi; Uehara, Takeshi; Iwaya, Mai; Nakajima, Tomoyuki; Miyagawa, Yusuke; Suga, Tomoaki; Ota, Hiroyoshi; Tanaka, Eiji;


Image quantification technology of the heterochromatin and euchromatin region for differential diagnosis in the lobular endocervical glandular hyperplasia
Diagn Cytopathol 2019(Feb. 13)
Author:Kimura F, Kobayashi T, Kanai R, Kobayashi Y, Yuhi O, Ota H, Yamaguchi M, Yokokawa Y, Uehara T, Ishii K


Trefoil factor family 2 protein: a potential immunohistochemical marker for aiding diagnosis of lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix
VIRCHOWS ARCHIV,474(1):79-86 2019(Jan.)
Author:Asaka, Shiho; Nakajima, Tomoyuki; Momose, Masanobu; Miyamoto, Tsutomu; Uehara, Takeshi; Ota, Hiroyoshi;


Intestinal Injury by Heat Conduction from Surgical Sealing Devices
JSLS-JOURNAL OF THE SOCIETY OF LAPAROENDOSCOPIC SURGEONS,23(1):- 2019
Author:Suzuki, Toshiro; Hattori, Ryouhei; Minagawa, Tomonori; Uehara, Takeshi; Ogawa, Teruyuki; Ishizuka, Osamu;


Upregulation of osteopontin expression via the interaction of macrophages and fibroblasts under IL-1b stimulation
CYTOKINE,110:63-69 2018(Oct.)
Author:Shimodaira, Takahiro; Matsuda, Kazuyuki; Uchibori, Takaaki; Sugano, Mitsutoshi; Uehara, Takeshi; Honda, Takayuki;


Leucine-rich repeat-containing G-protein-coupled receptor 5 expression and clinicopathological features of colorectal neuroendocrine neoplasms
PATHOLOGY INTERNATIONAL,68(8):467-472 2018(Aug.)
Author:Nakajima, Tomoyuki; Uehara, Takeshi; Kobayashi, Yukihiro; Kinugawa, Yasuhiro; Yamanoi, Kazuhiro; Maruyama, Yasuhiro; Suga, Tomoaki; Ota, Hiroyoshi;


Gastrointestinal manifestation of immunoglobulin G4-related disease: clarification through a multicenter survey
JOURNAL OF GASTROENTEROLOGY,53(7):845-853 2018(Jul.)
Author:Notohara, Kenji; Kamisawa, Terumi; Uchida, Kazushige; Zen, Yoh; Kawano, Mitsuhiro; Kasashima, Satomi; Sato, Yasuharu; Shiokawa, Masahiro; Uehara, Takeshi; Yoshifuji, Hajime; Hayashi, Hiroko; Inoue, Koichi; Iwasaki, Keisuke; Kawano, Hiroo; Matsubayashi, Hiroyuki; Moritani, Yukitoshi; Murakawa, Katsuhiko; Oka, Yoshio; Tateno, Masatoshi; Okazaki, Kazuichi; Chiba, Tsutomu;


Promoter hypomethylation of SKI in autoimmune pancreatitis
PATHOLOGY RESEARCH AND PRACTICE,214(4):492-497 2018(Apr.)
Author:Kinugawa, Yasuhiro; Uehara, Takeshi; Matsuda, Kazuyuki; Kobayashi, Yukihiro; Nakajima, Tomoyuki; Hamano, Hideaki; Kawa, Shigeyuki; Higuchi, Kayoko; Hosaka, Noriko; Shiozawa, Satoshi; Ishigame, Hiroki; Nakamura, Toshitsugu; Maruyama, Yasuhiro; Nakazawa, Koh; Nakaguro, Masato; Sano, Kenji; Ota, Hiroyoshi;


Evaluation of hemodynamic imaging findings of hypervascular hepatocellular carcinoma: comparison between dynamic contrast-enhanced magnetic resonance imaging using radial volumetric imaging breath-hold examination with k-space-weighted image contrast reconstruction and dynamic computed tomography during hepatic arteriography
JAPANESE JOURNAL OF RADIOLOGY,36(4):295-302 2018(Apr.)
Author:Kurozumi, Masahiro; Fujinaga, Yasunari; Kitou, Yoshihiro; Yamada, Akira; Ohya, Ayumi; Adachi, Yasuo; Tsukahara, Yoshinori; Nickel, Marcel D.; Maruyama, Katsuya; Uehara, Takeshi; Miyagawa, Shin-ichi; Kadoya, Masumi;


Degranulation and shrinkage of dark cells in eccrine glands and elevated serum carcinoembryonic antigen in patients with acquired idiopathic generalized anhidrosis
MODERN PATHOLOGY,31:209-209 2018(Mar.)
Author:Sano, Kenji; Uehara, Takeshi;


Pancreatobiliary Maljunction-Associated Gallbladder Cancer is as Common in the West as in the East, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Reflux-Associated Physio-Chemical Carcinogenesis
MODERN PATHOLOGY,31:683-684 2018(Mar.)
Author:Muraki, Takashi; Pehlivanoglu, Burcin; Memis, Bahar; Reid, Michelle; Uehara, Takeshi; Basturk, Olca; Klimstra, David; Jarnagin, William R.; Pernicka, Jennifer S. Golia; Ito, Tetsuya; Hasebe, Osamu; Okaniwa, Shinji; Horigome, Naoto; Hisa, Takeshi; Mittal, Pardeep; Maithel, Shishir; Sarmiento, Juan M.; Krasinskas, Alyssa; Koshiol, Jill; Lomberk, Gwen; Urrutia, Raul; Tsai, Susan; Christians, Kathleen K.; Evans, Douglas; Adsay, N. Volkan;


Rapid ABO genotyping by high-speed droplet allele-specific PCR using crude samples
JOURNAL OF CLINICAL LABORATORY ANALYSIS,32(1):- 2018(Jan.)
Author:Taira, Chiaki; Matsuda, Kazuyuki; Takeichi, Naoya; Furukawa, Satomi; Sugano, Mitsutoshi; Uehara, Takeshi; Okumura, Nobuo; Honda, Takayuki;


Characterization of clinically isolated thymidine-dependent small-colony variants of Escherichia coli producing extended-spectrum beta-lactamase
JOURNAL OF MEDICAL MICROBIOLOGY,67(1):33-39 2018(Jan.)
Author:Negishi, Tatsuya; Matsumoto, Takehisa; Horiuchi, Kazuki; Kasuga, Eriko; Natori, Tatsuya; Matsuoka, Mina; Ogiwara, Naoko; Sugano, Mitsutoshi; Uehara, Takeshi; Nagano, Noriyuki; Honda, Takayuki;


A Novel Mutation in the Fibrinogen B Chain (c.490G > A; End of Exon 3) Causes a Splicing Abnormality and Ultimately Leads to Congenital Hypofibrinogenemia
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(11):- 2017(Nov.)
Author:Taira, Chiaki; Matsuda, Kazuyuki; Arai, Shinpei; Sugano, Mitsutoshi; Uehara, Takeshi; Okumura, Nobuo;


Reflux-Associated Cholecystopathy Analysis of 76 Gallbladders From Patients With Supra-Oddi Union of the Pancreatic Duct and Common Bile Duct (Pancreatobiliary Maljunction) Elucidates a Specific Diagnostic Pattern of Mucosal Hyperplasia as a Prelude to Carcinoma
AMERICAN JOURNAL OF SURGICAL PATHOLOGY,41(9):1167-1177 2017(Sep.)
Author:Muraki, Takashi; Memis, Bahar; Reid, Michelle D.; Uehara, Takeshi; Ito, Tetsuya; Hasebe, Osamu; Okaniwa, Shinji; Horigome, Naoto; Hisa, Takeshi; Mittal, Pardeep; Freedman, Alexa; Maithel, Shishir; Sarmiento, Juan M.; Krasinskas, Alyssa; Koshiol, Jill; Adsay, Volkan;


Electron Microscopy Observation of Human Pulmonary Ultrastructure in Two Patients with High-Altitude Pulmonary Edema
HIGH ALTITUDE MEDICINE & BIOLOGY,18(3):288-291 2017(Sep.)
Author:Droma, Yunden; Kato, Akane; Ichiyama, Takashi; Kobayashi, Nobumitsu; Honda, Takayuki; Uehara, Takeshi; Hanaoka, Masayuki;


Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4
JOURNAL OF PATHOLOGY,242(1):16-23 2017(May)
Author:Hosoda, Waki; Chianchiano, Peter; Griffin, James F.; Pittman, Meredith E.; Brosens, Lodewijk A. A.; Noe, Michael; Yu, Jun; Shindo, Koji; Suenaga, Masaya; Rezaee, Neda; Yonescu, Raluca; Ning, Yi; Albores-Saavedra, Jorge; Yoshizawa, Naohiko; Harada, Kenichi; Yoshizawa, Akihiko; Hanada, Keiji; Yonehara, Shuji; Shimizu, Michio; Uehara, Takeshi; Samra, Jaswinder S.; Gill, Anthony J.; Wolfgang, Christopher L.; Goggins, Michael G.; Hruban, Ralph H.; Wood, Laura D.;


IL-6 trans-signaling is another pathway to upregulate Osteopontin
CYTOKINE,90:88-95 2017(Feb.)
Author:Uchibori, Takaaki; Matsuda, Kazuyuki; Shimodaira, Takahiro; Sugano, Mitsutoshi; Uehara, Takeshi; Honda, Takayuki;


PATZ1 knockdown enhances malignant phenotype in thyroid epithelial follicular cells and thyroid cancer cells
ONCOTARGET,8(47):82754-82772 2017
Author:Iesato, Asumi; Nakamura, Teruo; Izumi, Hiroto; Uehara, Takeshi; Ito, Ken-Ichi;


Methylation of Tumor Suppressor Genes in Autoimmune Pancreatitis
PANCREAS,46(5):614-618 2017
Author:Kinugawa, Yasuhiro; Uehara, Takeshi; Sano, Kenji; Matsuda, Kazuyuki; Maruyama, Yasuhiro; Kobayashi, Yukihiro; Nakajima, Tomoyuki; Hamano, Hideaki; Kawa, Shigeyuki; Higuchi, Kayoko; Hosaka, Noriko; Shiozawa, Satoshi; Ishigame, Hiroki; Ota, Hiroyoshi;


Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma
LABORATORY INVESTIGATION,96(12):1246-1255 2016(Dec.)
Author:Hoshino, Hitomi; Ohta, Makoto; Ito, Makoto; Uchimura, Kenji; Sakai, Yasuhiro; Uehara, Takeshi; Low, Shulin; Fukushima, Mana; Kobayashi, Motohiro;


Distribution of Lgr5-positive cancer cells in intramucosal gastric signet-ring cell carcinoma
PATHOLOGY INTERNATIONAL,66(9):518-523 2016(Sep.)
Author:Nakajima, Tomoyuki; Uehara, Takeshi; Maruyama, Yasuhiro; Iwaya, Mai; Kobayashi, Yukihiro; Ota, Hiroyoshi;


Human 3 beta-hydroxysteroid dehydrogenase type 1 in human breast cancer: clinical significance and prognostic associations
CANCER MEDICINE,5(7):1405-1415 2016(Jul.)
Author:Hanamura, Toru; Ito, Tokiko; Kanai, Toshiharu; Maeno, Kazuma; Shimojo, Yasuyo; Uehara, Takeshi; Suzuki, Takashi; Hayashi, Shin-ichi; Ito, Ken-ichi;


Evaluation of saliva as diagnostic materials for influenza virus infection by PCR-based assays
CLINICA CHIMICA ACTA,453:71-74 2016
Author:Sueki, Akane; Matsuda, Kazuyuki; Yamaguchi, Akemi; Uehara, Masayuki; Sugano, Mitsutoshi; Uehara, Takeshi; Honda, Takayuki;


Rapid diagnosis of acute promyelocytic leukemia with the PML-RARA fusion gene using a combination of droplet-reverse transcription-polymerase chain reaction and instant-quality fluorescence in situ hybridization
CLINICA CHIMICA ACTA,453:38-41 2016
Author:Shigeto, Shohei; Matsuda, Kazuyuki; Yamaguchi, Akemi; Sueki, Akane; Uehara, Masayuki; Sugano, Mitsutoshi; Uehara, Takeshi; Honda, Takayuki;


Neutrophil left shift and white blood cell count as markers of bacterial infection
CLINICA CHIMICA ACTA,457:46-53 2016
Author:Honda, Takayuki; Uehara, Takeshi; Matsumoto, Go; Arai, Shinpei; Sugano, Mitsutoshi;


Clinicopathological characterisation of duodenal adenocarcinoma with high CD44 variant 9 expression
PATHOLOGY,47(7):647-652 2015(Dec.)
Author:Maruyama, Yasuhiro; Uehara, Takeshi; Daikuhara, Seiichi; Kobayashi, Yukihiro; Nakajima, Tomoyuki; Matsumoto, Akihiro; Tanaka, Eiji; Ota, Hiroyoshi;


Evaluation of Mutational Testing of Preneoplastic Barrett's Mucosa by Next-Generation Sequencing of Formalin-Fixed, Paraffin-Embedded Endoscopic Samples for Detection of Concurrent Dysplasia and Adenocarcinoma in Barrett's Esophagus
JOURNAL OF MOLECULAR DIAGNOSTICS,17(4):412-419 2015(Jul.)
Author:Del Portillo, Armando; Lagana, Stephen M.; Yao, Yuan; Uehara, Takeshi; Jhala, Nirag; Ganguly, Tapan; Nagy, Peter; Gutierrez, Jorge; Luna, Aesis; Abrams, Julian; Liu, Yang; Brand, Randall; Sepulveda, Jorge L.; Falk, Gary W.; Sepulveda, Antonia R.;


Principal cells in gastric neoplasia of fundic gland (chief cell predominant) type show characteristics of immature chief cells
PATHOLOGY INTERNATIONAL,65(4):202-204 2015(Apr.)
Author:Ota, Hiroyoshi; Yamaguchi, Dai; Iwaya, Mai; Kobayashi, Mikiko; Tateiwa, Nobuyuki; Iwaya, Yugo; Momose, Masanobu; Uehara, Takeshi;


Three-Dimensional Analysis of Alveolar Wall Destruction in the Early Stage of Pulmonary Emphysema
CLINICAL ANATOMY,28(2):227-234 2015(Mar.)
Author:Kobayashi, Yukihiro; Uehara, Takeshi; Kawasaki, Kenji; Sugano, Mitsutoshi; Matsumoto, Takehisa; Matsumoto, Gou; Honda, Takayuki;


Cytokine profiles in the BAL fluid of IgG4-related respiratory disease compared with sarcoidosis
ERJ Open Res,1 2015
Author:Yamamoto H, Yasuo M, Ichiyama T, Ushiki A, Hanaoka M, Hamano H, Uehara T, Kawakami S, Matsui S, Kubo K


Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) as a Useful Immunohistochemical Marker for the Diagnosis of Adenocarcinoma of Small Intestine
ACTA HISTOCHEMICA ET CYTOCHEMICA,48(6):193-204 2015
Author:Daikuhara, Seiichi; Uehara, Takeshi; Higuchi, Kayoko; Hosaka, Noriko; Iwaya, Mai; Maruyama, Yasuhiro; Matsuda, Kazuyuki; Arakura, Norikazu; Tanaka, Eiji; Ota, Hiroyoshi;


Extracorporeal shock wave lithotripsy treatment of pancreatic stones complicated with advanced stage autoimmune pancreatitis
BMC GASTROENTEROLOGY,15:- 2015
Author:Maruyama, Masahiro; Watanabe, Takayuki; Kanai, Keita; Oguchi, Takaya; Asano, Jumpei; Ito, Tetsuya; Muraki, Takashi; Hamano, Hideaki; Arakura, Norikazu; Uehara, Takeshi; Kawa, Shigeyuki;


Signal intensity of the pancreas on magnetic resonance imaging: Prediction of postoperative pancreatic fistula after a distal pancreatectomy using a triple-row stapler
PANCREATOLOGY,15(4):380-386 2015
Author:Arai, Takuma; Kobayashi, Akira; Yokoyama, Takahide; Ohya, Ayumi; Fujinaga, Yasunari; Shimizu, Akira; Motoyama, Hiroaki; Furusawa, Norihiko; Sakai, Hiroshi; Uehara, Takeshi; Kadoya, Masumi; Miyagawa, Shin-ichi;


HER2 status in lung adenocarcinoma: A comparison of immunohistochemistry, fluorescence in situ hybridization (FISH), dual-ISH, and gene mutations
LUNG CANCER,85(3):373-378 2014(Sep.)
Author:Yoshizawa, Akihiko; Sumiyoshi, Shinji; Sonobe, Makoto; Kobayashi, Masashi; Uehara, Takeshi; Fujimoto, Masakazu; Tsuruyama, Tatsuaki; Date, Hiroshi; Haga, Hironori;


Comparison of histopathological features of pancreatic carcinoma and type 1 autoimmune pancreatitis
PATHOLOGY INTERNATIONAL,64(2):51-57 2014(Feb.)
Author:Uehara, Takeshi; Hamano, Hideaki; Kawa, Shigeyuki; Kobayashi, Yukihiro; Yoshizawa, Akihiko; Oki, Keiko; Nakata, Rie; Kobayashi, Akira; Sano, Kenji; Ota, Hiroyoshi;


Inflammation of colon adenoma in the setting of type 1 autoimmune pancreatitis
PATHOLOGY INTERNATIONAL,64(2):67-74 2014(Feb.)
Author:Uehara, Takeshi; Hamano, Hideaki; Suga, Tomoaki; Kawa, Shigeyuki; Yoshizawa, Akihiko; Kobayashi, Yukihiro; Murata, Kazuya; Oki, Keiko; Sano, Kenji; Onodera, Rie; Ota, Hiroyoshi;


IgG4-related disease-like fibrosis as an indicator of IgG4-related lymphadenopathy
ANNALS OF DIAGNOSTIC PATHOLOGY,17(5):416-420 2013(Oct.)
Author:Uehara, Takeshi; Masumoto, Junya; Yoshizawa, Akihiko; Kobayashi, Yukihiro; Hamano, Hideaki; Kawa, Shigeyuki; Oki, Keiko; Oikawa, Nao; Honda, Takayuki; Ota, Hiroyoshi;


H. pylori Infection Is Associated with DNA Damage of Lgr5-Positive Epithelial Stem Cells in the Stomach of Patients with Gastric Cancer
DIGESTIVE DISEASES AND SCIENCES,58(1):140-149 2013(Jan.)
Author:Uehara, Takeshi; Ma, Deqin; Yao, Yuan; Lynch, John P.; Morales, Knashawn; Ziober, Amy; Feldman, Michael; Ota, Hiroyoshi; Sepulveda, Antonia R.;


A phase II trial of gemcitabine, irinotecan, and panitumumab in advanced cholangiocarcinoma, with correlative analysis of EGFR, KRAS, and BRAF: An interim report
JOURNAL OF CLINICAL ONCOLOGY,30(15):- 2012
Author:Sohal, Davendra; Teitelbaum, Ursina R.; Uehara, Takeshi; Mykulowycz, Kristine; Watt, Christopher D.; Damjanov, Nevena; Giantonio, Bruce J.; Carberry, Mary; Wissel, Paul Stephen; Jacobs-Small, Mona; O'Dwyer, Peter J.; Sepulveda, Antonia; Sun, Weijing;


Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,109(21):8253-8258 2012
Author:McAfee, Quentin; Zhang, Zhihui; Samanta, Arabinda; Levi, Samuel M.; Ma, Xiao-Hong; Piao, Shengfu; Lynch, John P.; Uehara, Takeshi; Sepulveda, Antonia R.; Davis, Lisa E.; Winkler, Jeffrey D.; Amaravadi, Ravi K.;


Liquid-Based Thin-Layer Cytology Can Be Routinely Used in Samples Obtained via Fiberoptic Bronchoscope
ACTA CYTOLOGICA,55(1):69-78 2011
Author:Kobayashi, Yukihiro; Uehara, Takeshi; Ota, Hiroyoshi;


Radiologic Findings of IgG4-Related Disease
Current Immunology Reviews,7(2):186-203 2011
Author:Fujinaga, Y; Kadoya, M; Hamano, H; Kawa, S; Momose, M; Kawakami, S; Watanabe, T; Sugiyama, Y; Uehara, T


IgG4-Related Pleural Disease Diagnosed by a Re-Evaluation of Chronic Bilateral Pleuritis in a Patient Who Experienced Occasional Acute Left Bacterial Pleuritis
INTERNAL MEDICINE,50(8):893-897 2011
Author:Yamamoto, H; Suzuki, T; Yasuo, M; Kobayashi, O; Tsushima, K; Ito, M; Urushihata, K; Yamazaki, Y; Hanaoka, M; Koizumi, T; Uehara, T; Kawakami, S; Hamano, H; Kawa, S; Kubo, K


IgG4-related chronic rhinosinusitis: a new clinical entity of nasal disease
Acta Otolaryngol,131:518-526 2011
Author:Moteki H, Yasuo M, Hamano H, Uehara T, Usami S


Aberrant expression of TTF1, TTF2, and PDX1 and their diagnostic value in lobular endocervical glandular hyperplasia
Am J Clin Pathol,135:253-261 2011
Author:Ota H, Harada O, UeharaT, Hayama M, Ishii K.


Clinical features of central airway involvement in autoimmune pancreatitis
Eur Respir J,38:1233-1236 2011
Author:Yamamoto H, Yasuo M, Ito M, Yokoyama T, Hamano H, Uehara T, Kawakami S, Kubo K.


Impact of high-consistency area evaluated under hand-operated transrectal compression using a sonographic probe on prostate cancer detection: Clinicopathological analysis
INTERNATIONAL JOURNAL OF UROLOGY,17(10):876-880 2010(Oct.)
Author:Minagawa, Tomonori; Murata, Yasushi; Uehara, Takeshi; Imamura, Tetsuya; Ishizuka, Osamu;


Chronic Gastritis in the Setting of Autoimmune Pancreatitis
AMERICAN JOURNAL OF SURGICAL PATHOLOGY,34(9):1241-1249 2010(Sep.)
Author:Uehara, Takeshi; Hamano, Hideaki; Kawa, Shigeyuki; Sano, Kenji; Oki, Keiko; Kobayashi, Yukihiro; Nagaya, Tadanobu; Akamatsu, Taiji; Kurozumi, Masahiro; Fujinaga, Yasunori; Tanaka, Eiji; Honda, Takayuki; Ota, Hiroyoshi;


Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: an immunohistochemical approach
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES,17(3):211-222 2010(May)
Author:Nakanuma, Yasuni; Zen, Yoh; Harada, Kenichi; Ikeda, Hiroko; Sato, Yasunori; Uehara, Takeshi; Sasaki, Motoko;


Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement
PATHOLOGY INTERNATIONAL,60(3):167-174 2010(Mar.)
Author:Nakanuma, Yasuni; Zen, Yoh; Harada, Kenichi; Sasaki, Motoko; Nonomura, Akitaka; Uehara, Takeshi; Sano, Kenji; Kondo, Fukuo; Fukusato, Toshio; Tsuneyama, Koichi; Ito, Masahiro; Wakasa, Kenichi; Nomoto, Minoru; Minato, Hiroshi; Haga, Hironori; Kage, Masayoshi; Yano, Hirohisa; Haratake, Joji; Aishima, Shinichi; Masuda, Tomoyuki; Aoyama, Hajime; Miyakawa-Hayashino, Aya; Matsumoto, Toshiharu; Sanefuji, Hayato; Ojima, Hidenori; Chen, Tse-Ching; Yu, Eunsil; Kim, Ji-Hun; Park, Young Nyun; Tsui, Wilson;


Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease
J Gastroenterol,45:1263-1271 2010
Author:Hatta T, Fujinaga Y, Kadoya M, Ueda H, Murayama H, Kurozumi M, UedaK, Komatsu M, Nagaya T, Joshita S, Kodama R, Tanaka E, Uehara T, Sano K, Tanaka N


Distinct Expression of KL-6 Mucin in Chromophobe Renal Cell Carcinoma Compared with Other Renal Epithelial Cell Tumors
GLYCOBIOLOGY,19(11):1323-1323 2009(Nov.)
Author:Fukushima, Mana; Higuchi, Kayoko; Uehara, Takeshi; Honda, Takayuki; Ota, Hiroyoshi;


Clinical and pathological features of primary carcinoma of the cystic duct
JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY,16(1):75-82 2009(Jan.)
Author:Nakata, Takenari; Kobayashi, Akira; Miwa, Shiro; Soeda, Junpei; Uehara, Takeshi; Miyagawa, Shinichi;


Pulmonary involvement of autoimmune pancreatitis
Eur J Clin Invest,39:714-722 2009
Author:Tsushima K, Tanabe T, Yamamoto H, Koizumi T, Kawa S, Hamano H, Honda T, Uehara T, Kawakami S, Kubo K


Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver
MODERN PATHOLOGY,21(2):125-130 2008(Feb.)
Author:Fujii, Takahiko; Zen, Yoh; Sato, Yasunori; Sasaki, Motoko; Enomae, Mio; Minato, Hiroshi; Masuda, Shinji; Uehara, Takeshi; Katsuyama, Tsutomu; Nakanuma, Yasuni;


Autoimmune pancreatitis-associated prostatitis: Distinct clinicopathological entity
PATHOLOGY INTERNATIONAL,58(2):118-125 2008(Feb.)
Author:Uehara, Takeshi; Hamano, Hideaki; Kawakami, Masako; Koyama, Masamichi; Kawa, Shigeyuki; Sano, Kenji; Honda, Takayuki; Oki, Keiko; Ota, Hiroyoshi;


Liver function tests in patients with bacteremia
JOURNAL OF CLINICAL LABORATORY ANALYSIS,22(1):66-69 2008
Author:Kanai, Shinichiro; Honda, Takayuki; Uehara, Takeshi; Matsumoto, Takehisa;


Hyperplastic polyps and sessile serrated 'adenomas' of the colon and rectum display gastric pyloric differentiation
HISTOCHEMISTRY AND CELL BIOLOGY,128(5):445-455 2007(Nov.)
Author:Mochizuka, Akiyoshi; Uehara, Takeshi; Nakamura, Takamichi; Kobayashi, Yukihiro; Ota, Hiroyoshi;


Heterogeneous proliferation of type II pneumocytes in usual interstitial pneumonia
PATHOLOGY,38(5):433-436 2006(Oct.)
Author:Honda, Takayuki; Uehara, Takeshi; Sano, Kenji;


Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct
MODERN PATHOLOGY,19(9):1243-1254 2006(Sep.)
Author:Zen, Yoh; Fujii, Takahiko; Itatsu, Keita; Nakamura, Koichi; Konishi, Fumio; Masuda, Shinji; Mitsui, Takeshi; Asada, Yasuyuki; Miura, Shouji; Miyayama, Shiro; Uehara, Takeshi; Katsuyama, Tsutomu; Ohta, Tetsuo; Minato, Hiroshi; Nakanuma, Yasuni;


Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct
MODERN PATHOLOGY,19(9):1243-1254 2006
Author:Zen, Y; Fujii, T; Itatsu, K; Nakamura, K; Konishi, F; Masuda, S; Mitsui, T; Asada, Y; Miura, S; Miyayama, S; Uehara, T; Katsuyama, T; Ohta, T; Minato, H; Nakanuma, Y


Recurrence potential of diffuse-type giant cell tumor in the foot: radiologic and pathologic features
Foot Ankle Int,26:474-478 2005
Author:Shimizu T, Uehara T, Akahane T, Isobe K, Arai H


Distinct clinicopathological entity 'autoimmune pancreatitis-associated sclerosing cholangitis'
PATHOLOGY INTERNATIONAL,55(7):405-411 2005
Author:Uehara, T; Hamano, H; Kawa, S; Sano, K; Honda, T; Ota, H


Immunoglobulin G4-related lymphoplasmacytic sclerosing cholangitis that mimics infiltrating hilar cholangiocarcinoma: part of a spectrum of autoimmune pancreatitis?
GASTROINTESTINAL ENDOSCOPY,62(1):152-157 2005
Author:Hamano, H; Kawa, S; Uehara, T; Ochi, Y; Takayama, M; Komatsu, K; Muraki, T; Umino, J; Kiyosawa, K; Miyagawa, S


A three-dimensional analysis of blood vessels in bronchioloalveolar carcinoma
LUNG,182(6):343-353 2004
Author:Uehara, T; Honda, T; Sano, K; Hachiya, T; Ota, H


Cell lineage specificity of newly raised monoclonal antibodies against gastric mucins in normal, metaplastic, and neoplastic human tissues and their application to pathology diagnosis
AMERICAN JOURNAL OF CLINICAL PATHOLOGY,115(1):69-79 2001
Author:Ota, H; Hayama, M; Nakayama, J; Hidaka, H; Honda, T; Ishii, K; Fukushima, M; Uehara, T; Kurihara, M; Ishihara, K; Hotta, K; Katsuyama, T


学会発表
Immunophenotypic Classification of Endocervical Adenocarcinoma in situ Based on Comprehensive Immunohistochemical Markers: Gastric-Type, Gastrointestinal-Type, IntestinalType, and Müllerian-Type
The United States and Canadian Academy of Pathology Annual Meeting 2019 2019(Mar. 20)
Author:Shiho Asaka, Tomoyuki Nakajima, Takeshi Uehara, Hiroyoshi Ota


Correlation of Clinicopathological Features and LGR5 Expression in Colon Adenocarcinoma
The United States and Canadian Academy of Pathology Annual Meeting 2019 2019(Mar. 20)
Author:Koichi Sato, Takeshi Uehara, Tomoyuki Nakajima, Hiroyoshi Ota


Degranulation and shrinkage of dark cells in eccrine glands and elevated serum carcinoembryonic antigen in patients with acquired idiopathic generalized anhidrosis
United States and Canadian Academy of Pathology , The United States and Canadian Academy of Pathology Annual Meeting 2018(Mar. 21)
Author:Kenji Sano, Takeshi Uehara


Pancreatobiliary Maljunction-Associated Gallbladder Cancer is as common in the West as in the East, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Reflux-Associated Physio-Chemical Carcinogenesis
United States&Canadian academy of Pathology , The United States and Canadian Academy of Pathology Annual Meeting 2018(Mar. 19)
Author:Takashi Muraki, Burcin Pehlivanoglu, Bahar Memis, Michelle Reid, Takeshi Uehara, Olca Basturk, David Klimstra, William R Jarnagin, Jennifer S Golia Pernicka, Tetsuya Ito, Osamu Hasebe, Shinji Okaniwa, Naoto Horigome, Takeshi Hisa, Pardeep Mittal, Shishir Maithel, Juan M Sarmiento, Alyssa Krasinskas, Jill Koshiol, Gwen Lomberk, Raul Urrutia, Susan Tsai, Kathleen K Christians, Douglas Evans, N. Volkan Adsay


Characterization of Lgr5 Expression in Colorectal Neuroendocrine Tumor
The United States and Canadian Academy of Pathology , The United States and Canadian Academy of Pathology Annual Meeting 2017(Mar. 07)
Author:Tomoyuki Nakajima, Takeshi Uehara, Yasuhiro Maruyama, Yukihiro Kobayashi, Hiroyoshi Ota, Takayuki Honda


Cholecystopathy of PancreatoBiliary Maljunction (PBM): Analysis of 75 Gallbladders from Patients with PBM Elucidates a Diagnostic Pattern of Mucosal Hyperplasia
The United States and Canadian Academy of Pathology , The United States and Canadian Academy of Pathology Annual Meeting 2017(Mar. 07)
Author:Bahar Memis, Takashi Muraki, Michelle D Reid, Takeshi Uehara, Tetsuya Ito, Osamu Hasebe, Shinji Okaniwa, Naoto Horigome, Takeshi Hisa, Pardeep Mittal, Juan M Sarmiento, Alyssa Krasinskas, Volkan Adsay


Use of immunohistochemistry with antibody cocktail of IgG subclasses instead of IgG in IgG4-related diseases
The 32nd World Congress of the International Federation of Biomedical Laboratory Science 2016
Author:Rie Nakata, Takeshi Uehara, Yui Nakashima, Tomoyuki Nakajima, Yasuhiro Kinugawa, Yasuhiro Maruyama, Yukihiro Kobayashi, Takayuki Honda


Assessment of leucine-rich repeat-containing G-protein-coupled receptor 5 expression in colorectal neuroendocrine tumor
The 32nd World Congress of the International Federation of Biomedical Laboratory Science 2016
Author:Tomoyuki Nakajima, Takeshi Uehara, Yuko Otani, Yasuhiro Maruyama, Yukihiro kobayashi, Takayuki Honda


Type 1 autoimmune pancreatitis (AIP) confined to the pancreatic duct system with massive lobular effacement: A type of AIP that causes pancreatic atrophy after steroid treatment ?
United States&Canadian academy of Pathology(USCAP) 2016
Author:Kenji Notohara, Takahiro Nakazawa, Takeshi Uehara, Shigeyuki Kawa


Clinicopathological Characterization of Duodenal Carcinoma With High CD44 Variant 9 Expression
2015 Digestive Disease Week 2015(May)
Author:Maruyama, Yasuhiro; Uehara, Takeshi; Tomoyuki, Nakajima; Ota, Hiroyoshi;


Spatial Distribution of LGR5-Positive Cancer Cells in Mucosal Gastric Signet-Ring Cell Carcinoma
2015 Digestive Disease Week 2015(May)
Author:Tomoyuki, Nakajima; Uehara, Takeshi; Maruyama, Yasuhiro; Ota, Hiroyoshi;


CD44v9 Is Expressed in Human Duodenal Carcinoma and CD44v9-Positive Cancer Cells Exhibit Stem Cell-Like Features
United States&Canadian academy of Pathology(USCAP) 2015
Author:Maruyama, Yasuhiro; Uehara, Takeshi; Daikuhara, Seiichi; Ota, Hiroyoshi;


Next-Generation Sequencing Mutational Analysis of Intestinal Metaplasia and Neoplastic Lesions in Barrett's Esophagus from Endoscopic Samples
United States&Canadian academy of Pathology(USCAP) 2014 2014
Author:Armando Del Portillo, Yuan Yuan, Takeshi Uehara, Nirag Jhala, Tapan Ganguly, Stephen Lagana, Jorge L Gutierrez-Pajares, Jorge L Sepulveda, Yang Liu, Randall Brand, Gary W Falk, Antonia R Sepulveda


Mutational Analys is by Next - Generation Sequencing of Pre - Neoplastic Intestinal Metaplasia and Neoplastic Lesions in Barrett's Esophagus From Endoscopic Samples
2013 Digestive Disease Week 2013(May 20)
Author:Antonia R. Sepulveda, Yuan Yao, Takeshi Uehara, Nirag Jhala, Tapan Ganguly, Jorge Sepulveda, Yang Liu, Randall Brand , Gary W. Falk


Sensitive Quantitative CpGMethylation Testing in Random Colonic Biopsies for Risk Assessmen t of Coexisting Dysplasia in Ulcerative Colitis Patients
2013 Digestive Disease Week 2013(May 20)
Author:Antonia R. Sepulveda, Takeshi Uehara, Dara L. Aisner, Yuan Yao, Miguel Regueiro , Wen Yan, Junya Masumoto, John W. Tobias, Khushboo Jhala, Roger Day , Franz Fogt, Hiroyoshi Ota, Jorge Sepulv eda


DNA damage of Lgr5-positive Stem Cell Population in human stomach
United States&Canadian academy of Pathology(USCAP) 2012 2012(Mar. 21)
Author:Uehara T. Ma D. Yao Y.Lynch JP. Morales K. Ziober A. Feldman M. Ota H. Sepulveda AR.


Identification of CpG Promoter Methylation Gene Targets in Gastrointestinal Stromal Tumors(GISTs)
Association for Molecular Pathology 2011
Author:Aisner DL, Yao Y, Easler J, Harada S, Uehara T, Zhang P, Ahmad N, Sepulveda AR


Sensitive Quantitative Methylation Analyses for Risk Assessment of Coexisting Dysplasia in Ulcerative Colitis Patients
Association for Molecular Pathology 2011
Author:Uehara, T., Aisner, DL, Yao, Y., Yen, W., Regueiro, M., Fogt, F., Sepulveda JL., Sepulveda, AR.


Autoimmune Pancreatitis: West vs. East
United States&Canadian academy of Pathology(USCAP) 2008
Author:Mino-Kenudson, M., Smyrk, TC., Deshpande, V., Fujisawa, M., Shimizu, M., Uehara,T., Nakazawa, T., Kobashi, Y., Louwers, GY., Notohara, K

研究費
科学研究費補助金(研究代表者)
2017 - 2019 , 自己免疫性膵炎からの発癌責任分子の同定と病理診断への応用 , 基盤研究(C)
2013 - 2015 , 自己免疫性膵炎のDNAメチレーション異常についての検討 , 基盤研究(C)
2009 - 2010 , IgG4関連硬化性疾患の分子病理学的解明 , 若手研究(B)

科学研究費補助金(研究分担者)
2017 - 2019 , 脂質メタボローム解析のための臨床検査法の構築とその臨床応用 , 基盤研究(C)
2013 - 2014 , コムギ胚芽無細胞蛋白質合成によるIgG4関連腎疾患の抗原同定と腎病理形態の解析 , 挑戦的萌芽研究
2009 - 2011 , 気管支肺胞上皮癌線維化巣におけるリンパ管のリモデリング , 基盤研究(C)
2005 - 2007 , ピロリ菌発現ベクターを利用した病原性毒素の生細胞モニタリング解析 , 萌芽研究