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青山俊文  アオヤマ トシフミ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 代謝制御学FAX番号
職名教授メールアドレス
住所ホームページURL

更新日:2018/09/25

プロフィール

研究分野
生化学
現在の研究課題
肝臓解毒酵素(P450)の精製

肝臓解毒酵素(P450)遺伝子のクローニング

ワクシニアウイルス法による遺伝子発現の解毒酵素への応用

長鎖脂肪酸酸化酵素の精製

長鎖脂肪酸酸化酵素欠損症の病因遺伝子解析

核内受容体(PPAR)ノックアウトマウスの解析

C型肝炎ウイルス発癌機構の解析

アルコール依存症性障害の成因解析

糖尿病治療薬の開発

肥満化機構の解析

C型肝炎ウイルス発癌機構の解析と防御法の開発解明

除草剤による生殖毒性の成因解明

プラスチック可塑剤(環境ホルモン)による生殖毒性の機構解明と防御法の開発

所属学会
所属学会
日本生化学会
日本脂質生化学研究会
環境科学会
日本分子生物学会
日本未病システム学会
International Conference on the Bioscience of Lipids(ICBL)
学歴
出身大学院
1983 , 大阪大学 , 理学
1980 , 大阪大学 , 理学

出身学校・専攻等(大学院を除く)
1978 , 上智大学 , 理工学部

取得学位
理学博士
研究職歴等
研究職歴
1990-1998 , 信州大学医学部 助教授
1985-1990 , アメリカ国立衛生研究所 Visiting Associate
1983-1985 , 日本学術振興会 特定領域奨励研究員

研究活動業績

研究業績(著書・
発表論文等)
論文
PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca(2+) channels with full-length Ca(V)1.2 C-terminus.
Pflugers Arch,470(6):909-921 2018(Jun.)
Author:Guo X, Kashihara T, Nakada T, Aoyama T, Yamada M.


Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet.
Biochim Biophys Acta Mol Basis Dis,1863(12):3170-3182 2017(Dec.)
Author:Tanaka N, Takahashi S, Hu X, Lu Y, Fujimori N, Golla S, Fang ZZ, Aoyama T, Krausz KW, Gonzalez FJ.


Targeting nuclear receptors for the treatment of fatty liver disease.
Pharmacol Ther,179:142-157 2017(Nov.)
Author:Tanaka N, Aoyama T, Kimura S, Gonzalez FJ.


Decreased Fatty Acid β-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice.
Tohoku J Exp Med,242(3):229-239 2017(Jul.)
Author:Nakajima T, Yang Y, Lu Y, Kamijo Y, Yamada Y, Nakamura K, Koyama M, Yamaguchi S, Sugiyama E, Tanaka N, Aoyama T.


PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis.
J Nutr Biochem,39:77-85 2017(Jan.)
Author:Hu X, Tanaka N, Guo R, Lu Y, Nakajima T, Gonzalez FJ, Aoyama T.


Association between endotoxemia and histological features of nonalcoholic fatty liver disease.
World J Gastroenterol,23(4):712-722 2017(Jan.)
Author:Kitabatake H, Tanaka N, Fujimori N, Komatsu M, Okubo A, Kakegawa K, Kimura T, Sugiura A, Yamazaki T, Shibata S, Ichikawa Y, Joshita S, Umemura T, Matsumoto A, Koinuma M, Sano K, Aoyama T, Tanaka E.


PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis.
J Nutr Biochem,39:77-85 2017(Jan.)
Author:Hu X, Tanaka N, Guo R, Lu Y, Nakajima T, Gonzalez FJ, Aoyama T.


PPAR alpha-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice
ARCHIVES OF TOXICOLOGY,90(12):3061-3071 2016(Dec.)
Author:Harada, Yukiko; Tanaka, Naoki; Ichikawa, Motoki; Kamijo, Yuji; Sugiyama, Eiko; Gonzalez, Frank J.; Aoyama, Toshifumi;


Age-dependent PPAR alpha activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene
GLYCOCONJUGATE JOURNAL,33(6):927-936 2016(Dec.)
Author:Tian, Yangyang; Yang, Yang; Zhang, Xiaowei; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Lu, Yu; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifumi;


Age-dependent PPARα activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene.
Glycoconj J,33(6):927-936 2016(Dec.)
Author:Tian Y, Yang Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Lu Y, Moriya K, Koike K, Gonzalez FJ, Aoyama T.


PPARα-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice.
Arch Toxicol,90(12):3061-3071 2016(Dec.)
Author:Harada Y, Tanaka N, Ichikawa M, Kamijo Y, Sugiyama E, Gonzalez FJ, Aoyama T.


Peroxisome proliferator-activated receptor α-dependent renoprotection of murine kidney by irbesartan.
Clin Sci (Lond),130(21):1969-1981 2016(Nov.)
Author:Harada M, Kamijo Y, Nakajima T, Hashimoto K, Yamada Y, Shimojo H, Gonzalez FJ, Aoyama T.


Activation of PPAR alpha by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE,240(2):113-122 2016(Oct.)
Author:Yang, Yang; Feng, Yuyao; Zhang, Xiaowei; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Aoyama, Toshifumi;


【PPARα revisit】 PPARαと疾患 NASHとPPARα
The Lipid,27(4):336-342 2016(Oct.)
Author:田中直樹, 木村岳史, 長屋匡信, 小松通治, 青山俊文


【PPARα revisit】 PPARαと疾患 慢性腎臓病とPPARα
The Lipid,27(4):357-363 2016(Oct.)
Author:上條祐司, 青山俊文


Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE,53(1):581-590 2016(Jan.)
Author:Nakamura, Kozo; Koyama, Masahiro; Ishida, Ryuya; Kitahara, Takashi; Nakajima, Takero; Aoyama, Toshifumi;


Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs.
J Food Sci Technol,53(1):581-90 2016(Jan.)
Author:Nakamura K, Koyama M, Ishida R, Kitahara T, Nakajima T, Aoyama T.


Peroxisome proliferator-activated receptor alpha-dependent renoprotection of murine kidney by irbesartan
CLINICAL SCIENCE,130(21):1969-1981 2016
Author:Harada, Makoto; Kamijo, Yuji; Nakajima, Takero; Hashimoto, Koji; Yamada, Yosuke; Shimojo, Hisashi; Gonzalez, Frank J.; Aoyama, Toshifumi;


Activation of PPARα by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis.
Tohoku J Exp Med,240(2):113-22 2016
Author:Yang Y, Feng Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Aoyama T.


Serum sulfatide abnormality is associated with increased oxidative stress in hemodialysis patients.
Hemodial Int,19(3):429-38 2015(Jul.)
Author:Yuzhe H, Kamijo Y, Hashimoto K, Harada M, Kanno T, Sugiyama E, Kyogashima M, Oguchi T, Nakajima T, Kanno Y, Aoyama T.


Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARα.
Biochim Biophys Acta,1852(3):473-81 2015(Mar.)
Author:Komatsu M, Kimura T, Yazaki M, Tanaka N, Yang Y, Nakajima T, Horiuchi A, Fang ZZ, Joshita S, Matsumoto A, Umemura T, Tanaka E, Gonzalez FJ, Ikeda S, Aoyama T.


Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy.
BBA Clin,3:168-74 2015(Feb.)
Author:Nagaya T, Tanaka N, Kimura T, Kitabatake H, Fujimori N, Komatsu M, Horiuchi A, Yamaura T, Umemura T, Sano K, Gonzalez FJ, Aoyama T, Tanaka E.


One-pot esterification and amidation of phenolic acids.
Tetrahedron,70(3):8097-8107 2014
Author:Kozo Nakamura, Takero Nakajima, Toshifumi Aoyama, Sho Okitsu
Keywords:caffeic acid phenethyl ester


Chronic ethanol consumption decreases sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice.
Arch Toxicol,88(4):367-379 2014
Author:Hiroki Kanbe, Yuji Kamijo, Takero Nakajima, Naoki Tanaka, Eiko Sugiyama, Lixuan Wang, Zhong-Ze Fang, Atsushi Hara, Frank J Gonzalez, Toshifumi Aoyama
Keywords:sulfatides, ethanol, cerebroside sulfotransferase


Peroxisome proliferator-activated receptor alpha mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
GLYCOCONJUGATE JOURNAL,30(6):553-560 2013
Author:Nakajima, T; Kamijo, Y; Huang, YZ; Kimura, T; Tanaka, N; Sugiyama, E; Nakamura, K; Kyogashima, M; Hara, A; Aoyama, T


Two mechanistically distinct effects of dihydropyridine nifedipine on Ca(V)1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation
EUROPEAN JOURNAL OF PHARMACOLOGY,685(1-3):15-23 2012(Jun.)
Author:Sheng, Xiaona; Nakada, Tsutomu; Kobayashi, Motohiro; Kashihara, Toshihide; Shibazaki, Toshihide; Horiuchi-Hirose, Miwa; Gomi, Simmon; Hirose, Masamichi; Aoyama, Toshifumi; Yamada, Mitsuhiko


Fatty acid accumulation and resulting PPARalpha activation in fibroblasts due to trifunctional protein deficiency.
PPAR Research,2012:371691 2012
Author:Masato Wakabayashi, Yuji Kamijo, Takero Nakajima, Naoki Tanaka, Eiko Sugiyama, Tian Yangyung, Takefumi Kimura, Toshifumi Aoyama


Kidney transplantation recovers the reduction level of serum sulfatide in ESRD patients via processes correlated to oxidative stress and platelet count
GLYCOCONJUGATE JOURNAL,28(3-4):125-135 2011
Author:Wang, LX; Kamijo, Y; Matsumoto, A; Nakajima, T; Higuchi, M; Kannagi, R; Kyogashima, M; Aoyama, T; Hara, A


Serum Fragmented Cytokeratin 18 Levels Reflect the Histologic Activity Score of Nonalcoholic Fatty Liver Disease More Accurately Than Serum Alanine Aminotransferase Levels
JOURNAL OF CLINICAL GASTROENTEROLOGY,44(6):440-447 2010(Jul.)
Author:Tsutsui, Masaru; Tanaka, Naoki; Kawakubo, Masatomo; Sheena, Yo; Horiuchi, Akira; Komatsu, Michiharu; Nagaya, Tadanobu; Joshita, Satoru; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Tanaka, Eiji; Sano, Kenji


Nonalcoholic fatty liver disease in Japanese junior high school students: its prevalence and relationship to lifestyle habits
JOURNAL OF GASTROENTEROLOGY,45(6):666-672 2010(Jun.)
Author:Tsuruta, Goro; Tanaka, Naoki; Hongo, Minoru; Komatsu, Michiharu; Horiuchi, Akira; Hamamoto, Kaeko; Iguchi, Chieko; Nakayama, Yoshiko; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Tanaka, Eiji


Multiple roles of PPAR alpha in brown adipose tissue under constitutive and cold conditions
GENES TO CELLS,15(2):91-100 2010(Feb.)
Author:Komatsu, Makiko; Tong, Yuhong; Li, Yufeng; Nakajima, Takero; Li, Gang; Hu, Rui; Sugiyama, Eiko; Kamijo, Yuji; Tanaka, Naoki; Hara, Atsushi; Aoyama, Toshifumi


DOWN-REGULATION OFSREBP-1C IS ASSOCIATED WITH THE DEVELOPMENT OF BURNED-OUT NASH
JOURNAL OF HEPATOLOGY,52(Suppl. 1):S373-S374 2010
Author:Nagaya, T.; Tanaka, N.; Komatsu, M.; Joshita, S.; Umemura, T.; Ichijo, T.; Matsumoto, A.; Yoshizawa, K.; Aoyama, T.; Tanaka, E.


Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,390(4):1382-1388 2009(Dec.)
Author:Zhang, Xiaowei; Nakajima, Takero; Kamijo, Yuji; Li, Gang; Hu, Rui; Kannagi, Reiji; Kyogashima, Mamoru; Aoyama, Toshifumi; Hara, Atsushi


Kidney dysfunction induced by protein overload nephropathy reduces serum sulfatide levels in mice
NEPHROLOGY,14(7):658-662 2009(Oct.)
Author:Li, Gang; Hu, Rui; Kamijo, Yuji; Nakajima, Takero; Aoyama, Toshifumi; Ehara, Takashi; Shigematsu, Hidekazu; Kannagi, Reiji; Kyogashima, Mamoru; Hara, Atsushi


α型ペルオキシソーム増殖剤活性化受容体(PPARα): 脂肪肝疾患との関連
信州医学雑誌,56(6):347-358 2008(Dec.)
Author:田中直樹,青山俊文
Keywords:nuclear receptor,mitochondrial β-oxidation,oxidative stress,steatohepatitis,hepatitis C virus,核内受容体,ミトコンドリアβ酸化,酸化ストレス,脂肪肝炎,C型肝炎ウイルス


学会発表
イルベサルタンはマウス腎においてペルオキシソーム増殖剤活性化受容体alphaを介した腎保護作用を有する
日本腎臓学会誌 , 58(3):305 2016(May)
Author:原田真, 橋本幸始, 山田洋輔, 中嶌岳郎, 青山俊文, 上條祐司

教育活動実績

授業等
2002 , 生化学