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藤田佳子  フジタ ヨシコ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 生理学FAX番号
職名講師メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

プロフィール

研究分野
分子病態学
所属学会
所属学会
日本薬理学会
日本循環薬理学会
日本生理学会
日本動脈硬化学会
日本心血管内分泌代謝学会
日本薬学会
高血圧関連疾患モデル学会
学歴
出身大学院
2006 , 徳島大学大学院
受賞学術賞
2015 , 第23回バイエル循環器病研究助成受賞
2010 , 第14回国際SHRシンポジウム SHR学会賞
2010 , 第83回日本薬理学会年会優秀発表賞
2009 , 第45回高血圧関連疾患モデル学会梶原賞
2008 , 第18回日本循環薬理学会Young Investigator's Award
2005 , 第14回徳島医学会賞
研究職歴等
研究職歴
2005-2015 , 国立循環器病研究センター 血管生理学部 研究員

研究活動業績

研究業績(著書・
発表論文等)
論文
High Levels of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Stroke: An Age- and Sex-Matched Cross-Sectional Study.
J Atheroscler Thromb.,23(10):1222-1226 2016
Author:Yokota C, Sawamura T, Watanabe M, Kokubo Y, Fujita Y, Kakino A, Nakai M, Toyoda K, Miyamoto Y, Minematsu K.


Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin.
PLoS One.,11(5):e0154994 2016
Author:Yokoyama C, Aoyama T, Ido T, Kakino A, Shiraki T, Tanaka T, Nishigaki K, Hasegawa A, Fujita Y, Sawamura T, Minatoguchi S.


Developmental Endothelial Locus-1 (Del-1) Inhibits Oxidized Low-Density Lipoprotein Activity by Direct Binding, and Its Overexpression Attenuates Atherogenesis in Mice.
Circ J.,80(12):2541 2016
Author:Kakino A, Fujita Y, Nakano A, Horiuchi S, Sawamura T.


Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
FASEB J.,29(8):3342-3356 2015
Author:Yamamoto K, Kakino A, Takeshita H, Hayashi N, Li L, Nakano A, Hanasaki-Yamamoto H, Fujita Y, Imaizumi Y, Toyama-Yokoyama S, Nakama C, Kawai T, Takeda M, Hongyo K, Oguro R, Maekawa Y, Itoh N, Takami Y, Onishi M, Takeya Y, Sugimoto K, Kamide K, Nakagami H, Ohishi M, Kurtz TW, Sawamura T, Rakugi H.


Lectin-like oxidized low-density lipoprotein receptor-1 plays an important role in vascular inflammation in current smokers.
J Atheroscler Thromb.,20(6):585-590 2013
Author:Takanabe-Mori R, Ono K, Wada H, Takaya T, Ura S, Yamakage H, Satoh-Asahara N, Shimatsu A, Takahashi Y, Fujita M, Fujita Y, Sawamura T, Hasegawa K.


LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men.
Atherosclerosis.,229(1):240-245 2013
Author:Okamura T, Sekikawa A, Sawamura T, Kadowaki T, Barinas-Mitchell E, Mackey RH, Kadota A, Evans RW, Edmundowicz D, Higashiyama A, Nakamura Y, Abbott RD, Miura K, Fujiyoshi A, Fujita Y, Murakami Y, Miyamatsu N, Kakino A, Maegawa H, Murata K, Horie M, Mitsunami K, Kashiwagi A, Kuller LH, Ueshima H; ERA JUMP Study Group.


Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.
Arthritis Rheum.,64(4):1024-1034 2012
Author:Ishikawa M, Ito H, Akiyoshi M, Kume N, Yoshitomi H, Mitsuoka H, Tanida S, Murata K, Shibuya H, Kasahara T, Kakino A, Fujita Y, Sawamura T, Yasuda T, Nakamura T.


Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox.
Proc Jpn Acad Ser B Phys Biol Sci.,87(3):104-113 2011
Author:Nishizuka T, Fujita Y, Sato Y, Nakano A, Kakino A, Ohshima S, Kanda T, Yoshimoto R, Sawamura T.


An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) - utilization of anti-LOX-1 single- chain antibody fused to apoB fragment.
J Atheroscler Thromb.,18(9):818-828 2011
Author:Iwamoto S, Fujita Y, Kakino A, Yanagida K, Matsuda H, Yoshimoto R, Sawamura T.


Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation.
Clin Chem.,57(10):1398-1405 2011
Author:Fujita Y, Yamaguchi S, Kakino A, Iwamoto S, Yoshimoto R, Sawamura T.


C-reactive protein uptake by macrophage cell line via class-A scavenger receptor.
Clin Chem.,56(3):478-481 2010
Author:Fujita Y, Kakino A, Harada-Shiba M, Sato Y, Otsui K, Yoshimoto R, Sawamura T.


LOX index, a novel predictive biochemical marker for coronary heart disease and stroke.
Clin Chem.,56(4):550-558 2010
Author:Inoue N, Okamura T, Kokubo Y, Fujita Y, Sato Y, Nakanishi M, Yanagida K, Kakino A, Iwamoto S, Watanabe M, Ogura S, Otsui K, Matsuda H, Uchida K, Yoshimoto R, Sawamura T.


Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts.
Circ J.,74(4):723-729 2010
Author:Takaya T, Wada H, Morimoto T, Sunagawa Y, Kawamura T, Takanabe-Mori R, Shimatsu A, Fujita Y, Sato Y, Fujita M, Kimura T, Sawamura T, Hasegawa K.


LOX-1 mediates vascular lipid retention under hypertensive state.
J Hypertens.,28(6):1273-1280 2010
Author:Nakano A, Inoue N, Sato Y, Nishimichi N, Takikawa K, Fujita Y, Kakino A, Otsui K, Yamaguchi S, Matsuda H, Sawamura T.


Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans.
Lipids.,45(4):329-335 2010
Author:Matsumoto T, Fujita M, Sawamura T, Kakino A, Sato Y, Fujita Y, Matsuda H, Nakanishi M, Uchida K, Nakae I, Kanda H, Yoshida A, Miwa K, Hayashi H, Mitsunami K, Horie M.


Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects.
Clin Chem.,55(2):285-294 2009
Author:Fujita Y, Kakino A, Nishimichi N, Yamaguchi S, Sato Y, Machida S, Cominacini L, Delneste Y, Matsuda H, Sawamura T.


LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells.
Cardiovasc Res.,84(1):127-136 2009
Author:Sugimoto K, Ishibashi T, Sawamura T, Inoue N, Kamioka M, Uekita H, Ohkawara H, Sakamoto T, Sakamoto N, Okamoto Y, Takuwa Y, Kakino A, Fujita Y, Tanaka T, Teramoto T, Maruyama Y, Takeishi Y.


LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice.
J Mol Cell Cardiol.,44(1):76-83 2008
Author:Hu C, Chen J, Dandapat A, Fujita Y, Inoue N, Kawase Y, Jishage K, Suzuki H, Li D, Hermonat PL, Sawamura T, Mehta JL.


LOX-1 deletion alters signals of myocardial remodeling immediately after ischemia-reperfusion.
Cardiovasc Res.,76(2):292-302 2007
Author:Hu C, Dandapat A, Chen J, Fujita Y, Inoue N, Kawase Y, Jishage K, Suzuki H, Sawamura T, Mehta JL.


Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model.
Cardiovasc Res.,69(1):263-271 2006
Author:Hinagata J, Kakutani M, Fujii T, Naruko T, Inoue N, Fujita Y, Mehta JL, Ueda M, Sawamura T.