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金山直樹  カナヤマ ナオキ

教員組織電話番号
教育組織大学院総合医理工学研究科FAX番号
職名准教授(特定雇用)メールアドレスnkanayama[at]shinshu-u.ac.jp
住所〒380-8553 長野県長野市若里4-17-1ホームページURL

プロフィール

研究分野
生体関連高分子
コロイド・界面化学
バイオマテリアル
所属学会
所属学会
高分子学会
日本化学会
日本バイオマテリアル学会
日本分析化学会
日本核酸化学会
学歴
出身大学院
2002 , 東京工業大学、総合理工学研究科

出身学校・専攻等(大学院を除く)
1997 , 富山大学、工学部(化学生物工学科)

取得学位
博士(工学) , 東京工業大学
受賞学術賞
2018 , 第79回応用物理学会秋季学術講演会 ポスター賞(共同)
2017 , Inside Front Cover (Wiley-VCH, Small 2017, 13, 1702137)
2016 , Front Cover (Wiley-VCH, ChemistryOPEN 2016, 5, 508)
2016 , ACS Editor’s Choice (American Chemical Society, Langmuir 2016, 32, 13296)
2015 , Front Cover (Wiley-VCH, Small 2015, 11, 3153)
2014 , Front Cover (Royal Society of Chemistry, Biomaterials Science, 2014, 2, 819)
2013 , Frontispiece (Wiley-VCH, Chemistry –A European Journal, 2013, 19, 10794)
2012 , 高分子表面研究討論会 優秀発表賞
2011 , Cover Picture (Wiley-VCH, Macromolecular Bioscience 2011, 11, 187)
2010 , Editor’s Choice (Chemical Society of Japan, Chemistry Letters 2010, 39, 1008)
2006 , Cover Picture (Wiley-VCH, ChemMedChem 2006, 1, 439)
2001 , 2001 年日本液晶学会討論会 虹彩賞
研究職歴等
研究職歴
2016- , 信州大学大学院総合工学系研究科・准教授
2016- , 理化学研究所・客員研究員(兼務)
2012-2016 , 理化学研究所 前田バイオ工学研究室・研究員
2011-2012 , 理化学研究所 前田バイオ工学研究室・協力研究員
2008-2011 , 筑波大学大学院数理物質科学研究科 学際物質科学研究センター・講師(常勤)
2005-2008 , 理化学研究所 前田バイオ工学研究室・協力研究員
2004-2005 , 名古屋大学大学院工学研究科マテリアル理工学専攻・助手
2002-2004 , 科学技術振興事業団 CREST研究員

研究職歴以外の職歴
2015- , 東洋大学理工学部応用化学科・非常勤講師(兼務)

研究活動業績

研究業績(著書・
発表論文等)
著書
Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanoparticles for Gene Diagnosis and Directed Assembly
American Chemical Society , Targeted Nanosystems for Therapeutic Applications: New Concepts, Dynamic Properties, Efficiency, and Toxicity (ACS books) 2019
Author:Guoqing Wang, Yoshitsugu Akiyama, Naoki Kanayama, Tohru Takarada, Mizuo Maeda


「見て・診る」ための金ナノ粒子
ファルマシア , 54(1):31-35 2018
Author:金山直樹


医療応用を目指したナノ粒子型DNAハイブリット材料
工業材料 , 65(7):43-49 2017
Author:金山直樹


ナノ粒子上のDNAブラシ層が示す特異な性質
高分子 , 66(3):110-112 2017
Author:金山直樹、前田瑞夫


「診る」バイオマテリアル-情報を収集し,自律的にシグナル変換・出力する材料-
バイオマテリアル , 34:180-184 2016
Author:金山直樹


ナノバイオエンジニアリング
人工臓器 , 44:182-185 2015
Author:金山直樹、前田瑞夫


DNA密生層でみられる特異な界面現象
バイオマテリアル , 32:95-101 2014
Author:金山直樹、前田瑞夫


DNAコンジュゲート・ナノ粒子を利用した高性能バイオ診断
エヌ・ティー・エス出版 , 先端バイオマテリアルハンドブック , :418-422 2012
Author:金山直樹、前田瑞夫


DNA担持ナノ粒子 ~その奇妙な性質とバイオ応用~
CSJ CurrentReview09 金属および半導体ナノ粒子の科学(日本化学会編) , :124-132 2012
Author:金山直樹、前田瑞夫


ポリマーの生長・分解を利用するシグナル増幅
ぶんせき , 450:307-311 2012
Author:金山直樹、前田瑞夫


DNAコンジュゲート材料によるバイオ計測法の開発
ファルマシア , 46(4):317-322 2010
Author:金山直樹、前田瑞夫


第5章 バイオ計測技術 2. DNAコンジュゲートポリマーによるバイオ計測
シーエムシー出版 , 次世代医療のための高分子材料工学 , :252-262 2008
Author:金山直樹、前田瑞夫


Development of Supramolecular Nanocarrier for Gene Delivery Based on Cationic Block Copolymers
Springer , Non-viral Gene Therapy , :51-62 2005
Author:Yuichi Yamasaki, Woo-Dong Jang, Nobuhiro Nishiyama, Naoki Kanayama, Kazunori Kataoka


機能性有機超薄膜
高分子加工 , 49(6):242-250 2000
Author:金山直樹、池田富樹


DNA の相補的結合作用を利用したナノ粒子の構造化
高分子 , 46(2):86 1997
Author:金山直樹、北野博巳


論文
Stochastic Binding Process of Blunt-End Stacking of DNA Molecules Observed by Atomic Force Microscopy
Langmuir 2018
Author:Taito Sekine, Naoki Kanayama*, Kazunari Ozasa, Takashi Nyu, Tomohiro Hayashi*, Mizuo Maeda


Cross-Linking versus Non-Cross-Linking Aggregation of Gold Nanoparticles Induced by DNA Hybridization: A Comparison of the Rapidity of Solution Color Change
Bioconjugate Chemistry,28:270-277 2017
Author:Guoqing Wang, Yoshitsugu Akiyama, Shota Shiraishi, Naoki Kanayama, Tohru Takarada, Mizuo Maeda


Directed Assembly of Gold Nanorods by Terminal-Base Pairing of Surface-Grafted DNA
Small,13:1702137 2017
Author:Guoquin Wang, Yoshitsugu Akiyama, Naoki Kanayama, Tohru Takarada, Mizuo Maeda


Rapid Naked-Eye Discrimination of Cytochrome P450 Genetic Polymorphism via Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanoparticles
ChemistryOPEN,5:508-512 2016
Author:Yoshitsugu Akiyama, Guoqing Wang, Shota Shiraishi, Naoki Kanayama, Tohru Takarada, Mizuo Maeda


Terminal-Specific Interaction between Double-Stranded DNA Layers: Colloidal Dispersion Behavior and Surface Force
Langmuir,32:13296-13304 2016
Author:Naoki Kanayama, Taito Sekine, Kazunari Ozasa, Satomi Kishi, Takashi Nyu, Tomohiro Hayashi, Mizuo Maeda


Modulation of Interparticle Distance in Discrete Gold Nanoparticle Dimers and Trimers by DNA Single-Base Pairing
Small,11:11425-11433 2015
Author:Yoshitugu Akiyama, Hiroto Shikagawa, Naoki Kanayama, Tohru Takarada, Mizuo Maeda


Sulfobetaine-terminated PEG improves the qualities of an immunosensing surface
Biomaterials Science,2:819-826 2014
Author:Yukichi Horiguchi, Naoki Nakayama, Naoki Kanayama, Yukio Nagasaki


DNA dangling-end-induced colloidal stabilization of gold nanoparticles for colorimetric single-nucleotide polymorphism genotyping
Chemistry –A European Journal,20:17420-17425 2014
Author:Yoshitugu Akiyama, Hiroto Shikagawa, Naoki Kanayama, Tohru Takarada, Mizuo Maeda


Thermodynamics-Based Rational Design of DNA Block Copolymers for Quantitative Detection of Single-Nucleotide Polymorphisms by Affinity Capillary Electrophoresis
Analytical Chemistry,85:3153-3161 2014
Author:Ayumi Kimura, Naoki Kanayama, Atsushi Ogawa, Hideaki Shibata, Hideo Nakashita, Tohru Takarada, and Mizuo Maeda


Quantitative single-nucleotide polymorphism analysis in secondary-structured DNA by affinity capillary electrophoresis using a polyethylene glycol–peptide nucleic acid block copolymer
Analytical Biochemistry,433:150-152 2013
Author:Harumi Tsukada, Lal Mohan Kundu, Yukiharu Matsuoka, Naoki Kanayama, Tohru Takarada, Mizuo Maeda


Dumbbell-shaped DNA analytes amplified by polymerase chain reaction for robust single-nucleotide polymorphism genotyping by affinity capillary electrophoresis
Analytical Chemistry,85:5347-5352 2013
Author:Hideaki Shibata, Atsushi Ogawa, Naoki Kanayama, Tohru Takarada, Mizuo Maeda


DNA terminal breathing regulated by metal ions for colloidal logic gates
Chemistry –A European Journal,19:10794-10798 2013
Author:Naoki Kanayama, Tohru Takarada, Masahiro Fujita, Mizuo Maeda


DNA terminal mismatch-induced stabilization of polymer micelles from RAFT-generated poly(N-isopropyl acrylamide)-DNA block copolymers
Chemistry –An Asian Journal,8:3079-3084 2013
Author:Kyousuke Isoda, Naoki Kanayama, Masahiro Fujita, Tohru Takarada, Mizuo Maeda


Structural study on non-crosslinking aggregation of gold nanoparticles with DNA
Journal of Colloid and Interface Science,369:629-635 2012
Author:Masahiro Fujita, Yoshizumi Katafuchi, Kazuki Ito, Naoki Kanayama, Toru Takarada, Mizuo Maeda


Structural characterization of nanoparticles from thermoresponsive poly(N-isopropylacrylamide)-DNA conjugate
Journal of Colloid and Interface Science,374:315-320 2012
Author:Wei-Yang OOI, Masahiro Fujita, Pengju Pan, Hui-Ying Tang, Kumar Sudesh, Kazuki Ito, Naoki Kanayama, Tohru Takarada, Mizuo Maeda


Highly quantitative SNP genotyping by affinity capillary zone electrophoresis using PEG-oligodeoxyribonucleotide block copolymers
Electrophoresis,33:2122-2129 2012
Author:Harumi Tsukada, Takashi Watanabe, Naoki Kanayama, Tohru Takarada, Mizuo Maeda


Preparation and evaluation of highly dispersible and Ca2+ level responsive PEGylated calcium phosphate nanoparticle with PEG-block-poly(4-vinylbenzylphosphonate) for the application of drug carrier
Transactions of the Materials Research Society of Japan,37:337-340 2012
Author:Kei Asai, Naoki Kanayama, Yukio Nagasaki


Estimation of binding constants of PNA and secondary-structured DNA by affinity capillary electrophoresis
Analytical Chemistry,84:5204-5209 2012
Author:Lal Kundu, Harumi Tsukada, Yukiharu Matsuoka, Naoki Kanayama, Tohru Takarada, Mizuo Maeda


Polymer brush with pendent glucosylurea groups constructed on a glass substrate by RAFT polymerization
European Polymer Journal,48:1875-1882 2012
Author:Hiromi Kitano, Yan Liu, Ken-ichi Tokuwa, Lifu Li, Shintarou Iwanaga, Masato Nakamura, Naoki Kanayama, Kohji Ohno, Yoshiyuki Saruwatari


Enzymatic synthesis of poly(β-ethyl aspartate) by polyethylene glycol modified poly(aspartic acid) hydrolase-1
Macromolecular Bioscience,11:187-191 2011
Author:Tomohiro Hiraishi, Eriko Masuda, Daisuke Miyamoto, Naoki Kanayama, Hideki Abe, Mizuo Maeda


RAFT-generated poly(N-isopropylacrylamide)-DNA block copolymers for temperature-responsive formation of polymer micelles
Reactive and Functional Polymers,71:367-371 2011
Author:Kyosuke Isoda, Naoki Kanayama, Tohru Takarada, Mizuo Maeda


Rapid naked-eye detection of mercury ion based on non- crosslinking aggregation of double-stranded DNA carrying gold nanoparticles
Chemical Communications,47:2077-2079 2011
Author:Naoki Kanayama, Tohru Takarada, Mizuo Maeda


In vivo near-infrared bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-block- poly(4-vinylbenzyl phosphonate)
Nanoscale,3:3705-3713 2011
Author:Masao Kamimura, Naoki Kanayama, Kimikazu Tokuzen, Kohei Soga, Yukio Nagasaki


Preparation of highly dispersible and tumor-accumulative, iron oxide nanoparticles: multi-point anchoring of PEG-b-poly(4-vinylbenzylphosphonate) improves performance significantly
Colloids and Surfaces B: Biointerfaces,88:771-778 2011
Author:Kodai Ujiie, Naoki Kanayama, Kei Asai, Mikio Kishimoto, Yusuke Ohara, Yoshimasa Akashi, Keiichi Yamada, Shinji Hashimoto, Tatsuya Oda, Nobuhiro Ohkohchi, Hideto Yanagihara, Eiji Kita, Masayuki Yamaguchi, Hirofumi Fujii, Yukio Nagasaki,


Binding of β-Secretase to a Peptide Inhibitor-Carrying SAM
Colloid and Surfaces B, Biointerface,78:155-162 2010
Author:Hiromi Kitano, Yasuhiro Kondo, Daisuke Saito, Makoto Genmei-Ide, Hiroyuki Morita, Naoki Kanayama


Facile Creation of Biointerface on Commodity Plastic Surface by Combination of Atmospheric Plasma and Reactive Polymer Coating
Journal of Photopolymer Science and Technology,23:579-583 2010
Author:Naoki Kanayama, Swapan Kumar Saha, Naoki Nakayama, Jun Nakanishi, Katsuhisa Kitano, Satoshi Hamaguchi, Yukio Nagasaki


PEGylated polymer micelle-based nitric oxide (NO) photodonor with NO-mediated antitumor activity
Chemistry Letters,39:1008-1009 2010
Author:Naoki Kanayama, Kazuhiro Yamaguchi, Yukio Nagasaki


Cloning of Poly(Aspartic Acid) (PAA) Hydrolase-1 Gene from Pedobacter sp. KP-2 and Hydrolysis of Thermally Synthesized PAA by Its Gene Product
Macromolecular Bioscience,9:10-19 2009
Author:Tomohiro Hiraishi, Eriko Masuda, Madoka Nagata, Naoki Kanayama, Hideki Abe, Yoshiharu Doi, Mizuo Maeda


RAFT-Generated Polyacrylamide-DNA Block Copolymers for Single-Nucleotide Polymorphism Genotyping by Affinity Capillary Electrophoresis
Biomacromolecules,10:805-813 2009
Author:Naoki Kanayama, Ayumi Kimura, Hideaki Shibata, Daisuke Miyamoto, Tohru Takarada, Mizuo Maeda


Anti-Biofouling Property of a Telomer Brush with Pendent Glucosylurea Groups
Langmuir,25:9361-9368 2009
Author:Hiromi Kitano, Atsushi Hayashi, Hajime Takakura, Hisatomo Suzuki, Naoki Kanayama, Yoshiyuki Saruwatari


Affinity Capillary Electrophoretic DNA Separation Using PEG-Oligodeoxyribonucleotide Block Copolymers: Relationship between Peak Resolution and Affinity Strength
Journal of Separation Science,31:837-844 2008
Author:Naoki Kanayama, Tohru Takarada, Ayumi Kimura, Hideaki Shibata, Mizuo Maeda


Evaluation of Single-Base Substitution Rate in DNA by Affinity Capillary Electrophoresis
Analytica Chimica Acta,619:101-109 2008
Author:Naoki Kanayama, Tohru Takarada, Hideaki Shibata, Ayumi Kimura, Mizuo Maeda


Poly(Ethylene Glycol)-oligodeoxyribonucleotide Block Copolymers for Affinity Capillary Electrophoretic Separation of Single-stranded DNAs with a Single-base Difference
Reactive and Functional Polymers,67:1373-1380 2007
Author:Naoki Kanayama, Ayumi Kimura, Hideaki Shibata, Tohru Takarada, Mizuo Maeda


Cyclic RGD Peptide-Conjugated Polyplex Micelles as a Targetable Gene Delivery System Directing to Cells Possessing αvβ3 and αvβ5 Integrins
Bioconjugate Chemistry,18:1415-1423 2007
Author:Makoto Oba, Shigeto Fukushima, Naoki Kanayama, Kazuhiro Aoyagi, Nobuhiro Nishiyama, Hiroyuki Koyama, Kazunori Kataoka


Detection of base pairing of an oxidatively damaged guanine using colloidal stability change of DNA-linked polymer micelles
Nucleic Acids Symp. Series,51:305-306 2007
Author:Tohru Takarada, Emi Imaizumi, Katsuhito Kino, Keitaro Yoshimoto, Shinzi Ogasawara, Naoki Kanayama, Mizuo Maeda


Point Mutation Assay by Affinity Capillary Electrophoresis Using Poly(ethylene glycol)- oligodeoxyribonucleotide block copolymers
Nucleic Acids Symp. Series,51:337-338 2007
Author:Ayumi Kimura, Tohru Takarada, Naoki Kanayama, Hideaki Shibata, Mizuo Maeda


SAXS Measurement of Aggregate of DNA Modified Gold Nanoparticles
Nucleic Acids Symp. Series,51:335-336 2007
Author:Shizuto Yamakoshi, Yasuhiro Sakai, Yuuya Shinohara, Yoshiyuki Amemiya, Naoki Kanayama, Tohru Takarada, Mizuo Maeda, Kohzo Ito


A PEG-Based Biocompatible Block Catiomer with High Buffering Capacity for the Construction of Polyplex Micelles Showing Efficient Gene Transfer toward Primary Cells
ChemMedChem,1:439-444 2006
Author:Naoki Kanayama, Shigeto Fukushima, Nobuhiro Nishiyama, Keiji Itaka, Woo-Dong Jang, Kanjiro Miyata, Yuichi Yamasaki, Ung-il Chung, Kazunori Kataoka


PEGylated Gene Nanocarriers Based on Block Catiomers Bearing Ethylenediamine Repeating Units Directed to Remarkable Enhancement of Photochemical Transfection
Journal of Controlled Release,115:208-215 2006
Author:Arnida, Nobuhiro Nishiyama, Naoki Kanayama, Woo-Dong Jang, Yuichi Yamasaki, Kazunori Kataoka


PEGlated Polyplex Micelles from Triblock Catiomers with Spatially Ordered Layering of Condensed pDNA and Buffering Units for Enhanced Intracellular Gene Delivery
Journal of The American Chemical Society,127:2810-2811 2005
Author:Shigeto Fukushima, Kanjiro Miyata, Nobuhiro Nishiyama, Naoki Kanayama, Yuichi Yamasaki, Kazunori Kataoka


Lactose-Conjugated Polyion Complex Micelles Incorporating Plasmid DNA as a Targetable Gene Vector System: Their Preparation and Gene Transfecting Efficiency Against HepG2 Cells
Journal of Controlled Release,95:653-664 2004
Author:Daisuke Wakebayashi, Nobuhiro Nishiyama, Yuichi Yamasaki, Keiji Itaka, Naoki Kanayama, Atsushi Harada, Yukio Nagasaki, Kazunori Kataoka


Supramolecular Nanocarrier of siRNA from PEG-Based Block Catiomer Carrying Diamine Side Chain with Distinctive pKa Directed to Enhance Intercellular Silencing
Journal of The American Chemical Society,126:13612-13613 2004
Author:Keiji Itaka, Naoki Kanayama, Nobuhiro Nishiyama, Woo-Dong Jang, Yuichi Yamasaki, Kozo Nakamura, Hiroshi Kawaguchi, Kazunori Kataoka


Substrate Monolayers as Electrochemical Sensing Elements for α-Chymotrypsin
Journal of Colloid and Interface Science,250:134-141 2002
Author:Hiromi Kitano, Toshitaka Saito, Naoki Kanayama


Distinct Thermodynamic Behaviour of a Mesomorphic Gold Nanoparticle Covered with a Liquid-Crystalline Compound
Chemical Communications,:2640-2641 2001
Author:Naoki Kanayama, Osamu Tsutsumi, Akihiko Kanazawa, Tomiki Ikeda


Interfacial Recognition of Sugars by Boronic Acid Carrying Self-Assembled Monolayer
Langmuir,16:577-583 2000
Author:Naoki Kanayama, Hiromi Kitano


Complexation of Porphyrin with a Pyridine Moiety in Self-Assembled Mnolayers on Metal Surfaces
The Journal of Physical Chemistry B,104:271-278 2000
Author:Naoki Kanayama, Takaki Kanbara, Hiromi Kitano


Self-Assembled Monolayer of Sugar-Carrying Polymer Chain: Sugar Balls from 2-Methacryloyloxyethyl D-Glucopyranoside
Langmuir,15:482-488 1999
Author:Akira Yoshizumi, Naoki Kanayama, Yukari Maehara, Makoto Ide, Hiromi Kitano


Interfacial Recognition of Sugars by Novel Boronic Acid-Carrying Amphiphiles Prepared With a Lipophilic Radical Initiator
Langmuir,14:165-170 1998
Author:Hiromi Kitano, Mai Kuwayama, Naoki Kanayama, Kohji Ohno

研究費
共同研究
2018 - , 機能性新高分子テープの開発・実用化研究

科学研究費補助金(研究代表者)
2017 - , DNAブラシ界面間力の表層構造依存性に基づく「水和スイッチ」の創出 , 基盤研究C
2014 - 2017 , DNAブラシ界面間における特異な相互作用の発現に対する水和状態の寄与評価 , 基盤研究C
2012 - 2013 , 界面特性の異なる高密度DNAブラシを担持したナノ粒子の創製と細胞との相互作用評価 , 若手研究B
2009 - 2010 , 機能性微小空間を付与したDNAナノ粒子を用いる有害金属イオンの簡便・迅速検出 , 若手研究B
2007 - 2008 , DNA担持ポリマーナノミセルの精密構造制御と高感度センシングデバイスへの応用 , 若手研究B

科学研究費補助金(研究分担者)
2017 - , 固液界面現象解明のための溶液化学反応における電子状態ダイナミクス計測開発 , 基盤研究B
2013 - 2017 , DNAソフト界面の特性を活かしたバイオマテリアルの創製 , 基盤研究S

その他公的資金
2017 - 2017 , CpGオリゴDNA複合化ポリマーの構造と免疫賦活効果の相関評価(平成29年度 生体医歯工学共同研究拠点共同研究プロジェクト)

その他
2004 - 2004 , 「トロイの木馬」方式による高分子ナノコンポジット材料の簡便・安価な製造プロセスの開発に関する研究(平成16年度 小笠原科学技術振興財団研究助成金)

教育活動実績

授業等
前期 , 先進生命化学特論(分担)
前期 , 生命工学特論(分担)
後期 , 環境と生命の基礎化学
後期 , 科学リテラシー入門ゼミ
後期 , バイオ・プロセス工学演習(分担)
通年 , 研究者・技術者を目指す大学院生のキャリア設計