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上條 祐司  カミジヨウ ユウジ

教員組織学術研究院(医学系(附属病院))電話番号0263-37-2634
教育組織医学部附属病院 腎臓内科、血液浄化療法部FAX番号0263-32-9412
職名診療教授メールアドレスyujibeat@shinshu-u.ac.jp
住所〒3908621 松本市旭3-1-1ホームページURLhttp://www.shinshu-jinzou.ac.jp/

更新日:2021/08/22

プロフィール

兼担研究科・学部
信州大学 腎臓内科
COE・クラスタ・
研究グループ
信州大学腎臓内科 , 信州大学医学部代謝制御学
研究分野
腎臓学
自己免疫性疾患
透析学
分子生物学
腎薬理学
腎病理学
キーワード:腎 , 尿細管 , 糸球体 , 脂質代謝 , 腎病理
現在の研究課題
腎脂質代謝とautophagy連関変調と腎臓病との関連性について
キーワード:脂質代謝異常 , ペルオキシソーム増殖剤活性化受容体 , 不飽和脂肪酸 , オートファジー , 蛋白尿
PPARαを利用した腎疾患治療法の開発
キーワード:PPARα , 脂肪酸 , 尿細管 , 糸球体
腎疾患におけるスルファタイドの役割の解明
キーワード:sulfatides , 血液透析 , 末期腎不全 , 慢性腎臓病
所属学会
所属学会
日本内科学会
日本腎臓学会
日本透析学会
日本リウマチ学会
アフェレシス学会
日本移植学会
臨床腎移植学会
脂質生化学会
アメリカ腎臓学会
国際腎臓学会
ヨーロッパ腎臓学会
日本医工学治療学会
日本腎不全外科研究会
日本透析アクセス医学会

所属学会役職担当
2018- , 長野県透析研究会 , 会長
日本腎臓学会 , 評議員
日本透析医学会 , 評議員
日本アフェレシス学会 , 評議員
日本透析アクセス医学会 , 評議員
学歴
出身大学院
2001 , 信州大学医学部大学院

出身学校・専攻等(大学院を除く)
1994 , 新潟大学

取得学位
医学博士 , 信州大学医学部大学院
受賞学術賞
2018 , 第二回太田和夫賞
2008 , CKD award2008 奨励賞
2008 , 第13回有壬記念学術奨励賞
研究職歴等
研究職歴
2003-2006 , 信州大学大学院医学研究科助手(代謝制御学)
2002-2003 , 信州大学医学部附属加齢適応研究センター研究機関研究員

研究職歴以外の職歴
2014- , 信州大学医学部附属病院腎臓内科診療教授,血液浄化療法部准教授
2013- , 信州大学医学部附属病院准教授(学部内)
2012- , 信州大学医学部附属病院講師(腎臓内科)
2006- , 信州大学医学部附属病院助教(腎臓内科)
2001- , 信州大学医学部附属病院医員(第二内科)
1995- , 国立東信病院内科レジデント
1994- , 信州大学医学部附属病院研修医

研究活動業績

研究業績(著書・
発表論文等)
書籍等出版物
【"なぜ?""なに?"がサクッとわかる!新人スタッフのための血液透析のぎもんQ&A40~治療・原理編~】 血液透析とその原理にまつわるQ&A ECUMって何?どんな患者に行うの?(Q&A/特集), 透析ケア 24 4, 321
2018
Author:上條 祐司


【"なぜ?""なに?"がサクッとわかる!新人スタッフのための血液透析のぎもんQ&A40~治療・原理編~】 血液透析とその原理にまつわるQ&A 血液透析時に抗凝固薬を使うのはどうして?(Q&A/特集), 透析ケア 24 4, 322
2018
Author:上條祐司


理想的な腎代替療法バランスは…?, 臨床透析 34 , 965-966
2018
Author:上條祐司


難治性腹水症治療におけるCART(Cell-free and Concentrated ascites reinfusion Therapy)の現状, 信州医学雑誌 64 3, 159-160
2016
Author:山田洋輔、橋本幸始、上條祐司


慢性腎臓病とPPARα, The Lipid 27 , 61-67
2016
Author:上條祐司、青山俊文上條祐司、青山俊文


糖尿病性腎症患者におけるバスキュラーアクセスの問題点, 腎と透析 78 , 467-470
2015
Author:橋本 幸始, 上條 祐司, 神應 裕


脂質代謝異常と関連疾患-疾患モデルの作成と利用 担当:第1章「転写調節因子」第5節「PPARα」, 72~79
エル・アイ・シー 2015
Author:中嶌岳郎上條祐司、田中直樹、青山俊文中嶌岳郎、上條祐司、田中直樹、青山俊文


腎とミネラルウォーター, 腎臓内科・泌尿器 l2 , 623-628
2015
Author:上條祐司


透析中の合併症 VAトラブル, 腎と透析 76 , 418-422
2014
Author:橋本 幸始, 上條 祐司, 神應 裕


論文
Pemafibrate Protects against Fatty Acid-Induced Nephropathy by Maintaining Renal Fatty Acid Metabolism
METABOLITES,11(6) 2021(Jun.)
Author:Aomura, Daiki; Harada, Makoto; Yamada, Yosuke; Nakajima, Takero; Hashimoto, Koji; Tanaka, Naoki; Kamijo, Yuji;
Keywords:pemafibrate; peroxisomal proliferator-activated receptor alpha; renal fatty acid metabolism; lipotoxicity; nephrology;


Prevalence of latent tuberculosis infection and its risk factors in Japanese hemodialysis patients
CLINICAL AND EXPERIMENTAL NEPHROLOGY 2021
Author:Ogawa, Yohei; Harada, Makoto; Hashimoto, Koji; Kamijo, Yuji;
Keywords:Latent tuberculosis infection; Dialysis; Interferon-gamma release assay (IGRA); QuantiFERON;


Efficacy of plasma exchange for antineutrophil cytoplasmic antibody-associated systemic vasculitis: a systematic review and meta-analysis
ARTHRITIS RESEARCH & THERAPY,23(1) 2021
Author:Yamada, Yosuke; Harada, Makoto; Hara, Yuuta; Iwabuchi, Ryohei; Hashimoto, Koji; Yamamoto, Shuhei; Kamijo, Yuji;
Keywords:Microscopic polyangiitis; Churg-Strauss syndrome; Granulomatosis with polyangiitis; Plasma exchange; Meta-analysis;


Relationship between serum uric acid level and vascular injury markers in hemodialysis patients.
Int Urol Nephrol,52:1581-1591 2020(Aug.)
Author:Harada M, Fujii K, Yamada Y, Tsukada W, Tsukada M, Hashimoto K, Kamijo Y


Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation.
FASEB J.,34:9594-9614 2020(Jul.)
Author:Wang Y, Nakajima T, Diao P, Yamada Y, Nakamura K, Nakayama J, Tanaka N, Aoyama T, Kamijo Y


QUESTIONNARIE-BASED SURVEY ON PRACTICE PATTERNS OF INPATIENTS WITH HEMODIALYSIS AT ALL 42 NATIONAL HOSPITALS IN JAPAN
NEPHROLOGY DIALYSIS TRANSPLANTATION,35:1871-1871 2020(Jun.)
Author:Nakata, Takeshi; Kamijo, Yuji; Konta, Tsuneo;


POSTOPERATIVE MATURATION AND CHANGES IN CARDIAC FUNCTION DIFFER BETWEEN TYPES OF VASCULAR ACCESS
NEPHROLOGY DIALYSIS TRANSPLANTATION,35:1675-1675 2020(Jun.)
Author:Hashimoto, Koji; Kanno, Taro; Kamijo, Yuji; Kanno, Yutaka;


CLINICAL SIGNIFICANCE AND RELATED FACTORS OF GFR SLOPE IN A LARGE MULTICENTER OBSERVATIONAL STUDY IN JAPAN
NEPHROLOGY DIALYSIS TRANSPLANTATION,35:1114-1114 2020(Jun.)
Author:Kamijo, Yuji; Hashimoto, Koji; Yamada, Yosuke; Harada, Makoto; Aida, Masatsugu; Yamauchi, Shitotomo;


Cholesterol Emboli Co-Existing with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis in a 76-Year-Old Woman
Tohoku J Exp Med.,251:61-68 2020(May)
Author:Kojima R, Harada M, Yamaguchi A, Hashimoto K, Kamijo Y


A Case of Acute Kidney Injury in a Patient with Renal Hypouricemia without Intense Exercise
Case Rep Nephrol Dial,10:26-34 2020(Mar. 30)
Author:Aomura D, Sonoda K, Harada M, Hashimoto K, Kamijo Y


Thrombotic Thrombocytopenic Purpura Treated with Rituximab Associated with Primary Sjögren's Syndrome and Primary Hypothyroidism
Intern Med.,59:715-719 2020(Mar. 01)
Author:Okumura T, Hashimoto K, Aomura D, Kurasawa Y, Hara Y, Fujii K, Masuda T, Sonoda K, Yamaguchi A, Ogawa Y, Kamijo Y


Adequacy of decision-making based on each kidney function estimation method for Japanese living kidney donor candidates: a retrospective observational study
Renal Replacement Therapy,6 2020
Author:Koji Hashimoto, Makoto Harada, Yosuke Yamada, Mitsutoshi Sugano, Tomonori Minagawa, Teruyuki Ogawa, Osamu Ishizuka and Yuji Kamijo


Verification of serum albumin elevating effect of cell-free and concentrated ascites reinfusion therapy for ascites patients: a retrospective controlled cohort study.
Sci Rep.,9(1):10195 2019(Jul.)
Author:Yamada Y, Inui K, Hara Y, Fuji K, Sonoda K, Hashimoto K, Kamijo Y.


腎移植ドナー適応判定におけるクレアチニンクリアランスの妥当性について
2019(Jun.)
Author:上條祐司、橋本幸始、川崎健治、菅野光俊、皆川倫範、小川輝之、石塚修、神應裕


Features of high flow access in the elderly.
J Vasc Access.,20:71-75 2019(May)
Author:Kanno T, Kanno Y, Shiroi K, Kobayashi N, Matsushita N, Kamishima K, Hashimoto K, Kamijo Y.


Effects of hypertension and antihypertensive treatments on sulfatide levels in serum and its metabolism.
Hypertens Res.,42(5):598-609 2019(May)
Author:Guo R, Hu X, Yamada Y, Harada M, Nakajima T, Kashihara T, Yamada M, Aoyama T, Kamijo Y.


Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice.
Glycoconj J,36(1):1-11 2019(Feb.)
Author:Yamada Y, Harada M, Hashimoto K, Guo R, Nakajima T, Kashihara T, Yamada M, Aoyama T, Kamijo Y.


Peroxisome proliferator-activated receptor attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice
ARCHIVES OF TOXICOLOGY,93(1):149-161 2019(Jan.)
Author:Lu, Yu; Harada, Makoto; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kyogashima, Mamoru; Gonzalez, Frank J.; Aoyama, Toshifumi;
Keywords:High-cholesterol diet; Peroxisome proliferator-activated receptor (PPAR); Coagulation factors; Cardiovascular diseases; Sulfatides;


Influence of arteriovenous fistula on daily living behaviors involving the upper limbs in hemodialysis patients: a cross-sectional questionnaire study.
BMC Nephrol.,19:284 2018(Oct. 22)
Author:Hara Y, Sonoda K, Hashimoto K, Fuji K, Yamada Y, Kamijo Y.


難治性腹水を伴つた透析困難症に対して腹膜透析が有用であった一例.
長野県透析研究会誌,41:10-13 2018
Author:藤田識志, 鈴木智大, 原悠太, 藤井一聡, 山田洋輔, 園田光佑, 増田知恵, 山口晃典, 山田愛子, 小川洋平, 橋本幸始, 上條祐司


献腎登録システム変更に対する当院の取り組みと課題
長野県透析研究会誌,41:51-53 2018
Author:百瀬美希, 橋本幸始, 小川洋平, 藤田識志, 園田光佑, 増田知恵, 山口晃典, 山田愛子, 上條祐司


Technical Performance and Clinical Effectiveness of Drop Type With Adjustable Concentrator-Cell Free and Concentrated Ascites Reinfusion Therapy.
Artif Organs.,41:1135-1144 2017
Author:Yamada Y, Harada M, Yamaguchi A, Kobayashi Y, Chino T, Minowa T, Kosuge T, Tsukada W, Hashimoto K, Kamijo Y.


Protein Concentration of Refractory Ascites in Cancer Patients is Reflected by the Presence and Severity of Peritoneal and Liver Metastasis.
Ther Apher Dial.,21:263-269. 2017
Author:Yamada Y, Yamaguchi A, Harada M, Kurasawa Y, Hara Y, Yamazaki D, Fujita S, Sonoda K, Masuda T, Yamada A, Ogawa Y, Hashimoto K, Kamijo Y.


Identification of chronic kidney disease patient characteristics influencing the renoprotective effects of febuxostat therapy: a retrospective follow-up study.
BMC Nephrol.,18 2017
Author:Yamaguchi A, Harada M, Yamada Y, Hashimoto K, Kamijo Y.


Decreased Fatty Acid β-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice.
Tohoku J Exp Med.,242:229-239 2017
Author:Nakajima T, Yang Y, Lu Y, Kamijo Y, Yamada Y, Nakamura K, Koyama M, Yamaguchi S, Sugiyama E, Tanaka N, Aoyama T.


PPAR alpha-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice
ARCHIVES OF TOXICOLOGY,90(12):3061-3071 2016(Dec.)
Author:Harada, Yukiko; Tanaka, Naoki; Ichikawa, Motoki; Kamijo, Yuji; Sugiyama, Eiko; Gonzalez, Frank J.; Aoyama, Toshifumi;
Keywords:2,4-dichlorophenoxyacetic acid; PPAR alpha; Cholesterol; Leydig cell; Testosterone; Testicular toxicity;


Pure red cell aplasia induced by anti-erythropoietin antibodies, well-controlled with tacrolimus
INTERNATIONAL JOURNAL OF HEMATOLOGY,104(4):502-505 2016(Oct.)
Author:Hashimoto, Koji; Harada, Makoto; Kamijo, Yuji;


Activation of PPAR alpha by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE,240(2):113-122 2016(Oct.)
Author:Yang, Yang; Feng, Yuyao; Zhang, Xiaowei; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Aoyama, Toshifumi;


The Optimal Cut-offValue of Ankle Brachial Index for Screening Cardiovascular Disease Risk in Hemodialysis Patients
信州医学雑誌,64(3):135-146 2016(Jun.)
Author:HARADA Makoto, TSUKADA Wataru, TSUKADA Osamu, HASHIMOTO Koji, KAMIJO Yuji


Peroxisome proliferator-activated receptor α-dependent renoprotection of murine kidney by irbesartan.
Clin Sci (Lond).,130:1969-1981 2016
Author:Harada M, Kamijo Y, Nakajima T, Hashimoto K, Yamada Y, Shimojo H, Gonzalez FJ, Aoyama T.


Age-dependent PPARα activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene.
Glycoconj J 2016
Author:Tian Y, Yang Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Lu Y, Moriya K, Koike K, Gonzalez FJ, Aoyama T.


Acute Phosphate Nephropathy with Diffuse Tubular Injury Despite Limited Calcium Phosphate Deposition
INTERNAL MEDICINE,55(16):2229-2235 2016
Author:Yamada, Yosuke; Harada, Makoto; Yamaguchi, Akinori; Sugiyama, Mai; Kanno, Taro; Hashimoto, Koji; Ehara, Takashi; Shimojo, Hisashi; Shigematsu, Hidekazu; Kamijo, Yuji;


Outcomes of blood flow suppression methods of treating high flow access in hemodialysis patients with arteriovenous fistula
JOURNAL OF VASCULAR ACCESS,16:S28-S33 2015(Nov.)
Author:Kanno, Taro; Kamijo, Yuji; Hashimoto, Koji; Kanno, Yutaka;


Serum sulfatide abnormality is associated with increased oxidative stress in hemodialysis patients
HEMODIALYSIS INTERNATIONAL,19(3):429-438 2015(Jul.)
Author:Yuzhe, Huang; Kamijo, Yuji; Hashimoto, Koji; Harada, Makoto; Kanno, Taro; Sugiyama, Eiko; Kyogashima, Mamoru; Oguchi, Tomomasa; Nakajima, Takero; Kanno, Yutaka; Aoyama, Toshifumi;


Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice
ARCHIVES OF TOXICOLOGY,88(2):367-379 2014(Feb.)
Author:Kanbe, Hiroki; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Wang, Lixuan; Fang, Zhong-Ze; Hara, Atsushi; Gonzalez, Frank J.; Aoyama, Toshifumi;


A case of podocytic infolding glomerulopathy with multiple myeloma
BMC NEPHROLOGY,15 2014
Author:Harada, Makoto; Kamijo, Yuji; Ehara, Takashi; Shimojo, Hisashi; Shigematsu, Hidekazu; Higuchi, Makoto;


A case of adult Dent disease in Japan with advanced chronic kidney disease
CEN Case Rep,3:132-138 2014
Author:Ken S, Kamijo Y, Matsuoka D, Noda S, Hidaka Y, Mori T, Shimojo H, Ehara T, Miura K, Takita J, Sekine T, Igarashi T, Koike K


Peroxisome proliferator-activated receptor alpha mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
GLYCOCONJUGATE JOURNAL,30(6):553-560 2013(Aug.)
Author:Nakajima, Takero; Kamijo, Yuji; Huang Yuzhe; Kimura, Takefumi; Tanaka, Naoki; Sugiyama, Eiko; Nakamura, Kozo; Kyogashima, Mamoru; Hara, Atsushi; Aoyama, Toshifumi;
Keywords:CST; Fenofibrate; PPAR alpha; Sphingoglycolipid; Sulfoglycolipid;


最新のトピックス イヌリンクリアランスと推算糸球体ろ過量
信州医学雑誌 = The Shinshu medical journal,61(5):343-346 2013
Author:上條 祐司;


イヌリンクリアランスと推算糸球体ろ過量
信州医学雑誌,61(5):343-346 2013
Author:上條 祐司;


Peroxisome proliferator-activated receptor α mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs.
Glycoconj J.,30(6):553-560 2013
Author:Nakajima T, Kamijo Y, Yuzhe H, Kimura T, Tanaka N, Sugiyama E, Nakamura K, Kyogashima M, Hara A, Aoyama T.


Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010.
Clin Exp Nephrol,17:155-73 2013
Author:Sugiyama H, Yokoyama H, Sato H, Saito T, Kohda Y, Nishi S, Tsuruya K, Kiyomoto H, Iida H, Sasaki T, Higuchi M, Hattori M, Oka K, Kagami S, Kawamura T, Takeda T, Hataya H, Fukasawa Y, Fukatsu A, Morozumi K, Yoshikawa N, Shimizu A, Kitamura H, Yuzawa Y, Matsuo S, Kiyohara Y, Joh K, Nagata M, Taguchi T, Makino H; Committee for Standardization of Renal Pathological Diagnosis; Committee for Kidney Disease Registry; Japanese Society of Nephrology.


マウス protein-overload nephropathy に生じる腎機能障害は、肝臓スルファチド合成酵素の発現低下を介して、血清スルファチド値を低下させる
脂質生化学研究,54:200-203 2012(May 28)
Author:中嶌 岳郎; 上條 祐司; 杉山 英子; 生 暁娜; 張 暁〓; 高橋 京子; 京ヶ島 守; 青山 俊文; 原 厚;


Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR).
Clin Exp Nephrol,16:903-20 2012
Author:Yokoyama H, Sugiyama H, Sato H, Taguchi T, Nagata M, Matsuo S, Makino H, Watanabe T, Saito T, Kiyohara Y, Nishi S, Iida H, Morozumi K, Fukatsu A, Sasaki T, Tsuruya K, Kohda Y, Higuchi M, Kiyomoto H, Goto S, Hattori M, Hataya H, Kagami S, Yoshikawa N, Fukasawa Y, Ueda Y, Kitamura H, Shimizu A, Oka K, Nakagawa N, Ito T, Uchida S, Furuichi K, Nakaya I, Umemura S, Hiromura K, Yoshimura M, Hirawa N, Shigematsu T, Fukagawa M, Hiramatsu M, Terada Y, Uemura O, Kawata T, Matsunaga A, Kuroki A, Mori Y, Mitsuiki K, Yoshida H; Committee for the Standardization of Renal Pathological Diagnosis and for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology, and the Progressive Renal Disease Research of the Ministry of Health, Labour and Welfare of Japan.


Pharmacological and Toxicological Advances in PPAR-Related Medicines.
PPAR Res.,940964:1-2 2012
Author:Kamijo Y, Nicol CJ, Alexson SE.


PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling.
PPAR Res.,976089:1-11 2012
Author:Hashimoto K, Kamijo Y, Nakajima T, Harada M, Higuchi M, Ehara T, Shigematsu H, Aoyama T.


Long-term improvement of oxidative stress via kidney transplantation ameliorates serum sulfatide levels.
Clin Exp Nephrol.,16:959-967 2012
Author:Kamijo Y, Wang L, Matsumoto A, Nakajima T, Hashimoto K, Higuchi M, Kyogashima M, Aoyama T, Hara A.


Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice.
PPAR Res.,174932:1-10 2012
Author:Kimura T, Nakajima T, Kamijo Y, Tanaka N, Wang L, Hara A, Sugiyama E, Tanaka E, Gonzalez FJ, Aoyama T.


Hemodialysis-induced P-wave signal-averaged electrocardiogram alterations are indicative of vulnerability to atrial arrhythmias.
Circ J,76:612-617 2012
Author:Shimada K, Tomita T, Kamijo Y, Higuchi M, Ito K, Koizumi Y, Yamamoto K, Aizawa K, Koshikawa M, Kasai H, Izawa A, Miyashita Y, Kumazaki S, Koyama J, Ikeda U.


Fatty Acid Accumulation and Resulting PPARα Activation in Fibroblasts due to Trifunctional Protein Deficiency.
PPAR Res.,371691:1-7 2012
Author:Wakabayashi M, Kamijo Y, Nakajima T, Tanaka N, Sugiyama E, Yangyang T, Kimura T, Aoyama T.


Attenuation of kidney injuries maintains serum sulfatide levels dependent on hepatic synthetic ability: a possible involvement of oxidative stress.
Tohoku J Exp Med,227:1-12 2012
Author:Sheng X, Nakajima T, Wang L, Zhang X, Kamijo Y, Takahashi K, Tanaka N, Sugiyama E, Kyogashima M, Aoyama T, Hara A.


Treatment with cyclosporine A improves SLE disease activity of Japanese patients with diffuse proliferative lupus nephritis.
Clin Nephrol,76:136-143 2011
Author:Kamijo Y, Hashimoto K, Takahashi K, Ehara T, Shigematsu H, Higuchi M.


Pretreatment by low-dose fibrates protects against acute free fatty acid-induced renal tubule toxicity by counteracting PPARα deterioration.
Toxicol Appl Pharmacol,252:237-249 2011
Author:Takahashi K, Kamijo Y, Hora K, Hashimoto K, Higuchi M, Nakajima T, EharaT, Shigematsu H, Gonzalez FJ, Aoyama T


Pink urine syndrome.
Intern Med,50:2057 2011
Author:Okubo K, Okubo H, Kamijo Y, Higuchi M.


Kidney transplantation recovers the reduction level of serum sulfatide in ESRD patients via processes correlated to oxidative stress and platelet count.
Glycoconj J,28(3-4):125-135 2011
Author:Wang L, Kamijo Y, Matsumoto A, Nakajima T, Higuchi M, Kannagi R, Kyogashima M, Aoyama T, Hara A.


Multiple roles of PPARalpha in brown adipose tissue under constitutive and cold conditions.
Genes Cells,15:91-100 2010
Author:Komatsu M, Tong Y, Li Y, Nakajima T, Li G, Hu R, Sugiyama E, Kamijo Y, Tanaka N, Hara A, Aoyama T.


Effect of bezafibrate on hepatic oxidative stress: comparison between conventional experimental doses and clinically-relevant doses in mice.
Redox Rep,15:123-130 2010
Author:Nakajima T, Tanaka N, Li G, Hu R, Kamijo Y, Hara A, Aoyama T


Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,390(4):1382-1388 2009(Dec.)
Author:Zhang, Xiaowei; Nakajima, Takero; Kamijo, Yuji; Li, Gang; Hu, Rui; Kannagi, Reiji; Kyogashima, Mamoru; Aoyama, Toshifumi; Hara, Atsushi


Eicosapentaenoic acid lowers plasma and liver cholesterol levels in the presence of peroxisome proliferator-activated receptor alpha
CHEMISTRY AND PHYSICS OF LIPIDS,160:S21-S21 2009(Aug.)
Author:Sugiyama, Eiko; Li, Yufeng; Ishikawa, Tomoko; Tanaka, Naoki; Kamijo, Yuji; Yokoyama, Shin; Hara, Atsushi; Aoyama, Toshi-fumi;


PPAR{alpha} attenuates the proinflammatory response in activated mesangial cells.
Am J Physiol Renal Physiol.,296:F328-336 2009
Author:Kono K, Kamijo Y, Hora K, Takahashi K, Higuchi M, Kiyosawa K, Shigematsu H, Gonzalez FJ, Aoyama T.


Kidney dysfunction induced by protein overload nephropathy reduces serum sulfatide levels in mice.
Nephrology (Carlton),14:658-662 2009
Author:Li G, Hu R, Kamijo Y, Nakajima T, Aoyama T, Ehara T, Shigematsu H, Kannagi R, Kyogashima M, Hara A.


Bezafibrate at clinically relevant doses decreases serum/liver triglycerides via down-regulation of sterol regulatory element-binding protein-1c in mice: a novel peroxisome proliferator-activated receptor alpha-independent mechanism.
Mol Pharmacol,75:782-792 2009
Author:Nakajima T, Tanaka N, Kanbe H, Hara A, Kamijo Y, Zhang X, Gonzalez FJ, Aoyama T.


Eicosapentaenoic acid lowers plasma and liver cholesterol levels in the presence of peroxisome proliferators-activated receptor alpha.
Life Sci,83:19-28 2008
Author:Sugiyama E, Ishikawa Y, Li Y, Kagai T, Nobayashi M, Tanaka N, Kamijo Y, Yokoyama S, Hara A, Aoyama T.


Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice.
Biochem Pharmacol.,76:108-119 2008
Author:Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Hara A, Hu R, Li G, Li Y, Nakamura K, Gonzalez FJ, Aoyama T


PPAR alpha protects proximal tubular cells from acute fatty acid toxicity
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,18(12):3089-3100 2007(Dec.)
Author:Kamijo, Yuji; Hora, Kazuhiko; Kono, Keiichi; Takahashi, Kyoko; Higuchi, Makoto; Ehara, Takashi; Kiyosawa, Kendo; Shigematsu, Hidekazu; Gonzalez, Frank J.; Aoyama, Toshifumi;


Chemokine system and tissue infiltration in aggressive NK-cell leukemia
LEUKEMIA RESEARCH,31(9):1237-1245 2007(Sep.)
Author:Makishima, Hideki; Ito, Toshiro; Momose, Kayoko; Nakazawa, Hideyuki; Shimodaira, Shigetaka; Kamijo, Yuji; Nakazawa, Yozo; Ichikawa, Naoaki; Ueno, Mayumi; Kobayashi, Hikaru; Kitano, Kiyoshi; Saito, Hiroshi; Kiyosawa, Kendo; Ishida, Fumihiro;
Keywords:aggressive NK-cell leukemia; chemokine system; CCR5 ligand;


Serum sulfatides as a novel biomarker for cardiovascular disease in patients with end-stage renal failure.
Glycoconj J,24:565-571 2007
Author:Hu R, Li G, Kamijo Y, Aoyama T, Nakajima T, Inoue T, Node K, Kannagi R, Kyogashima M, Hara A.


Relationship between effluent levels of beta(2)-microglobulin and peritoneal injury markers in 7.5% icodextrin-based peritoneal dialysis solution.
Ther Apher Dial,11:296-300 2007
Author:Minami S, Hora K, Kamijo Y, Higuchi M.


Peroxisome proliferator-activated receptor alpha protects against glomerulonephritis induced by long-term exposure to the plasticizerdi-(2-ethylhexyl)phthalate.
J Am Soc Nephrol,18:176-188 2007
Author:Kamijo Y, Hora K, Nakajima T, Kono K, Takahashi K, Ito Y, Higuchi M, Kiyosawa K, Shigematsu H, Gonzalez FJ, Aoyama T.


Establishment of a quantitative, qualitative, and high-throughput analysis of sulfatides from small amounts of sera by matrix-assisted laser desorption ionization-time of flight mass spectrometry.
Anal Biochem,362:1-7 2007
Author:Li G, Hu R, Kamijo Y, Nakajima T, Aoyama T, Inoue T, Node K, Kannagi R, Kyogashima M, Hara A.


Peroxisome proliferator-activated receptor alpha-independent peroxisome proliferation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,346(4):1307-1311 2006
Author:Zhang, XG; Tanaka, N; Nakajuna, T; Kamijo, Y; Gonzalez, FJ; Aoyama, T


Haploinsufficiency in the PPAR alpha and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,350(2):370-376 2006
Author:Sugiyama, E; Tanaka, N; Nakajima, T; Kamijo, Y; Yokoyama, S; Li, YF; Gonzalez, FJ; Aoyama, T


難治性水疱性類天疱瘡に対して免疫吸着療法が有効であった1症例
長野県透析研究会誌,28:87-89 2005
Author:村木真紀子,高橋京子,林 布紀子,南 聡,河野啓一,上條浩司,市川 透,上條祐司,樋口 誠,白澤喜久子,新倉秀雄,洞 和彦


【透析患者の合併症】C型肝炎・肝硬変,便秘
医薬ジャーナル,41:2682-2685 2005
Author:上條祐司,樋口 誠,洞 和彦


Suppression of expression of muscle-associated proteins by PPARalpha in brown adipose tissue
Biochem Biophys Res Commun,336:76-83 2005
Author:Tong Y, Hara A, Komatsu M, Tanaka N, Kamijo Y, Gonzalez FJ, Aoyama T


Significance of chemokine receptor expression in aggressive NK cell leukemia
Leukemia,19:1169-1174 2005
Author:Makishima H, Ito T, Asano N, Nakazawa H, Shimodaira S, Kamijo Y, Nakazawa Y, Suzuki T, Kobayashi H, KiyosawaK, Ishida F


Epstein-Barr virus-related primary central nervous system lymphoma after cadaveric renal transplantation improved by treatment with high-dose methotrexate followed by irradiation
Nephrology,10:321-324 2005
Author:Higuchi M, HataT, Furuya S, Hosaka S, Kamijo Y, Kiyosawa K, Ishizuka O, Nishizawa O, Hora K


A case of drug-induced hypersensitivity syndrome with multiple organ involvement treated with plasma exchange
Ther Apher Dial,9:412-416 2005
Author:Higuchi M, Agatsuma T, Iizima M, Yamazaki Y, Saita T, Ichikawa T, Kamijo Y, Arakura H, Hora K, Kiyosawa K


Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage
Hepatology,40(4):972-980 2004
Author:Nakajima T, Kamijo Y, Tanaka N, Sugiyama E, Tanaka E, Kiyosawa K, Fukushima Y, Peters JM, Gonzalez FJ, Aoyama T


Granulocytaheresis with adacolumn in the treatment of four patients with intractable ulcerative colitis
Jpn J Apheresis,23:189-195 2004
Author:Higuchi M, Shinji A, Nakamura N, Akamatsu T, Arakura H, Ichikawa T, Hora K, Kamijo Y, Kaneko Y, Kakegawa T, Kiyosawa K


CAPD施行中のサルコイドーシス患者に発症した壊死性胆嚢炎の1例
長野県透析研究会誌,27:95-97 2004
Author:林 布紀子,南 聡,高橋京子,河野啓一,上條浩司,掛川哲司,金子洋子,市川 透,上條祐司,樋口 誠,清澤研道,新倉秀雄,白澤喜久子,洞 和彦


血奨交換(PE)が著効したMPO-ANCA関連肺腎症候群の1例
長野県透析研究会会誌,26:51-54 2003
Author:南 聡,河野啓一,上條浩司,掛川哲司,小林信彦,市川 透,金子洋子,上條祐司,樋口 誠,清澤研道,平田聖文,新倉秀雄,白澤喜久子,洞 和彦


経過中多彩なアレルギー症状を伴い,多発血栓症を合併したheparin起因性血小板減少症の1例
日本透析医学会雑誌,36:1343-1348 2003
Author:小山貴之,南 聡,河野啓一,掛川哲司,上條浩司,小林信彦,市川 透,金子洋子,上條祐司,樋口 誠,清澤研道,平田聖文,新倉秀雄,洞 和彦


Younger onset myeloperoxidase-specific antineutrophil cytoplasmic antibody-(MPO-ANCA) related glomerulonephritis accompanied with nephrotic syndrome
Clin Nephrol,60:275-278 2003
Author:Kaneko Y, Kamijo Y, Kobayashi N, Higuchi M, Ehara T, Hora K, Shigematsu S, Kiyosawa K


Structural and phenotypic changes of podocyte in puromycin aminonucleosisde and protamine sulfate intermittent treated rat model.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,14:155A-155A 2003
Author:Ichikawa, T; Shimojo, H; Kaneko, Y; Kamijo, Y; Higuchi, M; Hora, K; Kiyosawa, K; Otani, M; Ehara, T; Shigematsu, H


Renal constitutive expression of fatty acid-metabolizing enzymes and adaptive response to starvation in peroxisome proliferator-activated receptor alpha-null mice.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,14:72A-72A 2003
Author:Kamijo, Y; Hora, K; Kiyosawa, K; Gonzalez, FJ; Aoyama, T


POEMS syndrome caused refractory ascites in a polycystic disease patient undergoing hemodialysis
Clin Exp Nephrol,7:301-305 2003
Author:Higuchi M, Kamijo H, Koyama T, Kaneko Y, Kamijo Y, Shirakawa H, Hora K, Kiyosawa K


In vivo stabilization of nuclear retinoid X receptor α in the presence of peroxisome proliferator-activated receptor α
FEBS Lett,543:120-124 2003
Author:Tanaka N, Hora K, Makishima H, Kamijo Y, Kiyosawa K, Gonzalez FJ, Aoyama T


Expression of hepatocyte growth factor is induced by the interaction between human mesangial cells and monocytes
Nephron Exp Nephrol,94:146-153 2003
Author:Koyama T, Hora K, Ako S, Kamijo Y, Higuchi M


Effect of long-term administration of cyclosporin aon young adult patients with carried over IgA nephropathy.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,14:796A-796A 2003
Author:Higuchi, M; Kaneko, Y; Kamijo, H; Kamijo, Y; Kiyosawa, K; Shigematsu, H; Hora, K


Chronic inhibition of nitric oxide production deteriorated diabetic nephropathy in Otsuka-Long-Evans Tokushima Fatty rats.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,14:905A-905A 2003
Author:Kamijo, H; Higuchi, M; Kaneko, Y; Kamijo, Y; Hora, K; Kiyosawa, K


腎生検で診断し得たコレステロール塞栓症の2例-腎組織に出現した炎症細胞についての検討-
信州医学雑誌,50:361-369 2002
Author:江原孝史,上條祐司,金子洋子,中沢功,重松秀一


抗GBM抗体及びMPO-ANCAが陽性であった半月体形成性腎炎の一例
日本腎臓学会誌,44:632 2002
Author:河野啓一,上條裕司,掛川哲司,小林信彦,小山貴之,上條浩司,金子洋子,市川 透,樋口 誠,清澤研道,重松秀一,平田聖之,洞 和彦


中性液への変更によって腹膜刺激症状が消失したCAPDの1例
長野県透析研究会誌,25:97-98 2002
Author:平田聖文,洞 和彦,小林信彦,上條浩司,小山貴之,掛川哲司,金子洋子,市川 透,上條祐司,樋口 誠,清澤研道


Persistent contact of macrophages with transformed mesangial cells is an important factor for inducing glomerulosclerosis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,13:134A-134A 2002
Author:Kaneko, Y; Nakazawa, K; Shiozawa, S; Yamamoto, M; Kamijo, Y; Higuchi, M; Hora, K; Kiyosawa, K; Shigematsu, H


Novel function of peroxisome proliferator-activated, receptor a in glomerular filtrate reabsorption.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,13:493A-493A 2002
Author:Kamijo, Y; Hora, K; Tanaka, N; Kiyosawa, K; Gonzalez, FJ; Aoyama, T


Muenchausen syndromeの1例
日本内科学会雑誌,91:3289-3291 2002
Author:上條祐司,須澤兼一,北野喜良,川 茂幸,清澤研道


Identification of functions of peroxisome proliferator-activated receptor alpha in proximal tubules
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,13(7) 2002
Author:Kamijo, Y; Hora, K; Tanaka, N; Usuda, N; Kiyosawa, K; Nakajima, T; Gonzalez, FJ; Aoyama, T


A case of nephrotic syndrome due to lupus nephritis which was controlled with low-density lipoprotein apheresis
THERAPEUTIC APHERESIS,6(6):459-462 2002
Author:Kamijo, Y; Kaneko, Y; Ichikawa, T; Kobayashi, N; Koyama, T; Kakegawa, T; Kamijo, H; Kono, K; Minami, S; Tanaka, N; Arakura, H; Hirata, M; Higuchi, M; Kiyosawa, K; Hora, K


Sex-dependent regulation of hepatic peroxisome proliferation in mice by trichloroethylene via peroxisome proliferator-activated receptor alpha (PPAR alpha)
CARCINOGENESIS,21(4):677-682 2000
Author:Nakajima, T; Kamijo, Y; Usuda, N; Liang, Y; Fukushima, Y; Kametani, K; Gonzalez, FJ; Aoyama, T


Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity
JOURNAL OF BIOLOGICAL CHEMISTRY,275(29):22293-22299 2000
Author:Watanabe, K; Fujii, H; Takahashi, T; Kodama, M; Aizawa, Y; Ohta, Y; Ono, T; Hasegawa, G; Naito, M; Nakajima, T; Kamijo, Y; Gonzalez, FJ;Aoyama, T


講演・口頭発表等
内科入院患者における窓際病床への入院とせん妄発症率の関連性の検討
第117回日本内科学会総会 2020
Presenter:青村大輝、山田洋輔、原田真、原悠太、藤井一聡、園田光佑、橋本幸始、上條祐司


ABO不適合移植後にpassengrer lymphocyte syndromeを発症した一例
第53回 日本臨床腎移植学会
Presenter:松井大介、原悠太、山口晃典、橋本幸始、皆川倫範、鈴木都史郎、小川輝之、石塚修、上條祐司


トシリズマブ治療中にネフローゼ症候群を認めた関節リウマチの一例
第64回日本リウマチ学会学術集会


多施設共同研究によるGFR slopeの重要性と関連因子の解析
Presenter:上條祐司、橋本幸始、山田洋輔、原田真


Dialysis-requiring AKIにおける循環血漿量を意識したナトリウム補充
第63回日本腎臓学会学術総会


腎移植後の移植腎動脈硬化病変の推移と関連因子の検討
第63回日本腎臓学会学術総会
Presenter:原悠太、山口晃典、青村大輝、岩渕良平、藤井一聡、山田洋輔、園田光佑、増田知恵、原田真、橋本幸始、上條祐司


著明な腎機能の改善が得られた抗GBM抗体型腎炎の一例
第50回日本腎臓学会東部学術大会
Presenter:浅井麻理子、原田真、山口晃典、藤井一聡、岩渕良平、原悠太、横田杏理、増田知恵、園田光佑、橋本幸始、上條祐司


ANCA関連血管炎に対する血漿交換療法:系統的レビュー・メタアナリシス
Presenter:山田洋輔、原田真、橋本幸一始、上條祐司


落差式CARTにおけるポリエーテルスルホン濾過膜とポリエチレン濾過膜の性能比較
第41回日本アフェレシス学会学術大会
Presenter:犬井啓太、山田洋輔、原田真、橋本幸始、上條祐司


透析患者の治療の歴史
第65回日本透析医学会学術集会・総会
Presenter:上條祐司


献腎移植待機患者の透析施設での管理
第65回日本透析医学会学術集会・総会
Presenter:上條祐司


腸管出血性大腸炎O157による溶血性尿毒症症候群に対し血液透析,血漿交換療法を要した成人女性の一例
第65回日本透析医学会学術集会・総会
Presenter:岩渕良平、原田真、山口晃典、青村大輝、藤井一聡、山田洋輔、園田光佑、増田知恵、橋本幸始、上條祐司


落差式CARTにおけるポリスルホン濾過膜とポリエチレン濾過膜の性能比較
Presenter:上條祐司、山田洋輔、犬井啓太、原田真、橋本幸始


心不全合併CRRT患者に対する高張Na輸液/経管栄養を併用した除水方法
第65回日本透析医学会学術集会・総会
Presenter:山口晃典、園田光佑、青村大輝、岩渕良平、原悠太、藤井一聡、山田洋輔、増田知恵、原田真、橋本幸始、上條祐司


バスキュラーアクセス術前因子と術後経過に関する検討
第65回日本透析医学会学術集会・総会
Presenter:橋本幸始、上條祐司、神應太郎、神應裕


シャントアクセスの術後経過に関する検討
第24回日本透析アクセス医学会学術集会
Presenter:橋本幸始、上條祐司、神應太朗、神應裕

特許等知的財産
登録済特許
血栓傾向データ収集方法
研究費
受託研究
2010 - 2015 , ARB 製剤のPPARα活性化作用に関する検討

科学研究費補助金(研究代表者)
2018 - 2020 , 慢性腎臓病における血清スルファチド異常の臨床的重要性と機序の解明 , 基盤研究(C)(一般)
2013 - 2015 , PPARα活性化による腎実質細胞保護を目的とした新たな慢性腎臓病治療法の開発 , 基盤研究(C)
2010 - 2012 , PPARαアゴニストを利用した新たな慢性腎臓病治療法の開発 , 基盤研究(C)

その他
心臓血管病における血清スルファチド異常の意義解明を目的とした臨床、基礎的研究

教育活動実績

授業等
ユニット講義(尿量の異常、尿の性状の異常)
ユニット講義(一次性糸球体病変)
ユニット講義(二次性糸球体病変)
ユニット講義(血液浄化と透析合併症)
ユニット講義(膠原病―腎病変)
腎移植-内科系
前期 , ユニット講義(腎の構造と機能)
後期 , 腎生理学
留学生受入
前期人数:5 , 後期人数:5

管理運営実績

管理運営実績
学内兼務職
血液浄化療法部長 , 血液浄化マネージメント
材料部副部長
腎臓内科診療教授

学部内委員会等
IRB , 委員長
材料小委員会 , 議長
新内科専門医プログラム委員会 , 委員
准講会 , 幹事