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吉村 豪兼  ヨシムラ ヒデカネ

教員組織学術研究院(医学系(附属病院))電話番号
教育組織医学部附属病院 耳鼻咽喉科頭頚部外科FAX番号
職名講師メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

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学歴
取得学位
医学博士 , 信州大学
学士(医学) , 信州大学

研究活動業績

研究業績(著書・
発表論文等)
論文
A comparative analysis of genetic hearing loss phenotypes in European/American and Japanese populations
HUMAN GENETICS,139(10):1315-1323 2020(Oct.)
Author:Walls, W. Daniel; Moteki, Hideaki; Thomas, Taylor R.; Nishio, Shin-ya; Yoshimura, Hidekane; Iwasa, Yoichiro; Frees, Kathy L.; Nishimura, Carla J.; Azaiez, Hela; Booth, Kevin T.; Marini, Robert J.; Kolbe, Diana L.; Weaver, A. Monique; Schaefer, Amanda M.; Wang, Kai; Braun, Terry A.; Usami, Shin-ichi; Barr-Gillespie, Peter G.; Richardson, Guy P.; Smith, Richard J.; Casavant, Thomas L.;


Genetic testing has the potential to impact hearing preservation following cochlear implantation.
Acta Otolaryngol.,140(6):438-444 2020(Jun.)
Author:Yoshimura H, Moteki H, Nishio SY, Miyajima H, Miyagawa M, Usami SI.


Cochlear Implantation From the Perspective of Genetic Background
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY,303(3):563-593 2020(Mar.)
Author:Usami, Shin-ichi; Nishio, Shin-ya; Moteki, Hideaki; Miyagawa, Maiko; Yoshimura, Hidekane;
Keywords:cochlear implant; hearing loss; gene; genetic etiology; electric acoustic stimulation;


Cochlear Implantation From the Perspective of Genetic Background.
Anat Rec (Hoboken).,303(3):563-593 2020(Mar.)
Author:Usami SI, Nishio SY, Moteki H, Miyagawa M, Yoshimura H.


Genetic testing has the potential to impact hearing preservation following cochlear implantation
ACTA OTO-LARYNGOLOGICA,140(6):438-444 2020
Author:Yoshimura, Hidekane; Moteki, Hideaki; Nishio, Shin-ya; Miyajima, Hiroki; Miyagawa, Maiko; Usami, Shin-ichi;
Keywords:Hearing preservation; hearing loss; cochlear implant; residual hearing;


Electric-acoustic stimulation with longer electrodes for potential deterioration in low-frequency hearing
ACTA OTO-LARYNGOLOGICA,140(8):632-638 2020
Author:Yoshimura, Hidekane; Moteki, Hideaki; Nishio, Shin-ya; Usami, Shin-ichi;
Keywords:Hearing preservation; electric-acoustic stimulation; hearing loss; cochlear implant; residual hearing;


Hair Cell Transduction Efficiency of Single- and Dual-AAV Serotypes in Adult Murine Cochleae
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT,17:1167-1177 2020
Author:Omichi, Ryotaro; Yoshimura, Hidekane; Shibata, Seiji B.; Vandenberghe, Luk H.; Smith, Richard J. H.;


蝸牛瘻孔を伴う中耳真珠腫に対する水中内視鏡下瘻孔閉鎖術
耳鼻咽喉科臨床,113(6):346-347 2020
Author:吉村 豪兼;宇佐美 真一


巨大口蓋扁桃結石例
耳鼻咽喉科臨床,113(11):707-711 2020
Author:横田 修;吉村 豪兼;安川 梨香;岩谷 舞;茂木 英明;宇佐美 真一
Abstract:

A tonsillolith is derived from chronic tonsillitis. Herein, we report the case of a patient with a "giant" tonsillolith, who was treated by bilateral tonsillectomy.

A 46-year-old female patient presented to our hospital with a history of pharyngeal pain on the right side. Physical examination revealed a whitish firm mass in the right tonsil and soft palate. CT, MRI scan and biopsy were performed, and based on the findings, we diagnosed the patient as having a giant tonsillolith, and not cancer of the oropharynx, as was initially suspected. Since she had chronic tonsillitis, we selected treatment by bilateral tonsillectomy with removal of the giant tonsillolith. Her symptom resolved after the surgery.

In general, a giant tonsillolith is relatively rare, but imaging studies are useful for differentiating it from other pharyngeal diseases and for obtaining a definitive diagnosis. Irrespective of the laterality, bilateral tonsillectomy is an effective treatment for a giant tonsillolith.


Keywords:tonsillolith;tonsillectomy;pharyngeal pain;cancer of the oropharynx


メニエール病非定型例における内リンパ水腫の検討
Equilibrium Research,79(6):535-540 2020
Author:森 健太郎;塚田 景大;福岡 久邦;岩佐 陽一郎;吉村 豪兼;横田 陽;杉山 健二郎;宇佐美 真一
Abstract:

 Objective: The purpose of this study was to investigate the incidence of endolymphatic hydrops (EH) and the clinical features in patients with atypical Ménière's disease (aMD), by 3-T gadolinium-enhanced magnetic resonance imaging (MRI).

 Methods: Thirty-three patients who were diagnosed as having aMD participated in this study. Out of the 33 patients, 23 were classified as having cochlear MD (CMD) and the remaining 10 as having vestibular MD (VMD). 3-T MRI was performed 24 hours after intratympanic injection of gadolinium in 24 patients, and 4 hours after intravenous injection of gadolinium in the remaining 9 patients. We investigated the prevalence rate of EH, the relationship between detection of EH and the duration of illness, and the transition rate to classical MD in the study participants. In addition, in the CMD group, the degree of hearing fluctuation was also evaluated.

 Results and Conclusions: The incidence of EH was 78.3% (18/23) in the CMD group and 40% (4/10) in the VMD group. There was no significant difference in the prevalence of EH in relation to the duration of illness between the two groups. The degree of hearing fluctuation in the patient group with CMD was slightly greater in the patients with EH than in those without EH. It was assumed that patients with other diseases causing episodic vertigo were diagnosed could be misdiagnosed as having VMD, and that 3-T MRI with gadolinium injection could be a good diagnostic tool for confirming the presence of EH.


Keywords:magnetic resonance imaging;atypical Meniere's disease;gadolinium


Insights into the Biology of Hearing and Deafness Revealed by Single-Cell RNA Sequencing.
Cell Rep.,26(11):3160-3171 2019(Mar.)
Author:Ranum PT, Goodwin AT, Yoshimura H, Kolbe DL, Walls WD, Koh JY, He DZZ, Smith RJH.


Targeted Allele Suppression Prevents Progressive Hearing Loss in the Mature Murine Model of Human TMC1 Deafness.
Mol Ther.,27(3):681-690 2019(Mar.)
Author:Yoshimura H, Shibata SB, Ranum PT, Moteki H, Smith RJH.


Targeted Allele Suppression Prevents Progressive Hearing Loss in the Mature Murine Model of Human TMC1 Deafness
MOLECULAR THERAPY,27(3):681-690 2019
Author:Yoshimura, Hidekane; Shibata, Seiji B.; Ranum, Paul T.; Moteki, Hideaki; Smith, Richard J. H.;


Insights into the Biology of Hearing and Deafness Revealed by Single-Cell RNA Sequencing
CELL REPORTS,26(11):3160-+ 2019
Author:Ranum, Paul T.; Goodwin, Alexander T.; Yoshimura, Hidekane; Kolbe, Diana L.; Walls, William D.; Koh, Jin-Young; He, David Z. Z.; Smith, Richard J. H.;


Bilateral delayed endolymphatic hydrops evaluated by bilateral intratympanic injection of gadodiamide with 3T-MRI.
PLoS One.,13(12):e0206891 2018(Dec.)
Author:Iwasa YI, Tsukada K, Kobayashi M, Kitano T, Mori K, Yoshimura H, Fukuoka H, Usami SI.


Enhanced viral-mediated cochlear gene delivery in adult mice by combining canal fenestration with round window membrane inoculation
SCIENTIFIC REPORTS,8 2018
Author:Yoshimura, Hidekane; Shibata, Seiji B.; Ranum, Paul T.; Smith, Richard J. H.;


Bilateral delayed endolymphatic hydrops evaluated by bilateral intratympanic injection of gadodiamide with 3T-MRI
PLOS ONE,13(12) 2018
Author:Iwasa, Yoh-ichiro; Tsukada, Keita; Kobayashi, Masafumi; Kitano, Tomohiro; Mori, Kentaro; Yoshimura, Hidekane; Fukuoka, Hisakuni; Usami, Shin-ichi;


Intravenous rAAV2/9 injection for murine cochlear gene delivery.
Sci Rep,7(1):9609 2017(Aug.)
Author:Shibata SB, Yoshimura H, Ranum PT, Goodwin AT, Smith RJH.


Frequency of Usher syndrome type 1 in deaf children by massively parallel DNA sequencing.
J Hum Genet,61(5):419-22 2016(May)
Author:Yoshimura H, Miyagawa M, Kumakawa K, Nishio SY, Usami S.


【めまい-新しい流れとその周辺-】 新しい検査・解釈 MRIと内リンパ水腫
JOHNS,32(1):37-40 2016(Jan.)
Author:宇佐美 真一, 福岡 久邦, 吉村 豪兼


Novel ABHD12 Mutations in PHARC Patients: The Differential Diagnosis of Deaf-Blindness
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY,124:77S-83S 2015(May)
Author:Yoshimura, Hidekane; Hashimoto, Takao; Murata, Toshinori; Fukushima, Kunihiro; Sugaya, Akiko; Nishio, Shin-ya; Usami, Shin-ichi;


Identification of a Novel CLRN1 Gene Mutation in Usher Syndrome Type 3: Two Case Reports
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY,124:94S-99S 2015(May)
Author:Yoshimura, Hidekane; Oshikawa, Chie; Nakayama, Jun; Moteki, Hideaki; Usami, Shin-ichi;


Gene Expression Profiles of the Cochlea and Vestibular Endorgans: Localization and Function of Genes Causing Deafness
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY,124:6S-48S 2015(May)
Author:Nishio, Shin-ya; Hattori, Mitsuru; Moteki, Hideaki; Tsukada, Keita; Miyagawa, Maiko; Naito, Takehiko; Yoshimura, Hidekane; Iwasa, Yoh-ichiro; Mori, Kentaro; Shima, Yutaka; Sakuma, Naoko; Usami, Shin-ichi;


USH2 Caused by GPR98 Mutation Diagnosed by Massively Parallel Sequencing in Advance of the Occurrence of Visual Symptoms
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY,124:123S-128S 2015(May)
Author:Moteki, Hideaki; Yoshimura, Hidekane; Azaiez, Hela; Booth, Kevin T.; Shearer, A. Eliot; Sloan, Christina M.; Kolbe, Diana L.; Murata, Toshinori; Smith, Richard J. H.; Usami, Shin-ichi;


喉頭截開術にて摘出し脂肪充填を行った喉頭筋上皮腫例
耳鼻咽喉科臨床,108(9):719-723 2015
Author:小林 正史; 吉村 豪兼; 市瀬 彩; 塚田 景大; 海沼 和幸; 岩崎 聡; 宇佐美 真一;
Keywords:myoepithelioma; larynx; laryngofissure;


パッと見てサッと押さえる! 科別で覚える 診る看るカンタン手術イラスト 耳鼻咽喉科
OPE nursing = オペナーシング : the Japanese journal of operating room nursing,29(12):1088-1091 2014(Dec.)
Author:吉村 豪兼; 岩崎 聡; 加我 君孝;


A clinical experience of 'STAMP' plate-guided Bonebridge implantation
ACTA OTO-LARYNGOLOGICA,134(10):1042-1046 2014(Oct.)
Author:Takumi, Yutaka; Matsumoto, Nozomu; Cho, Byunghyun; Ono, Hidenori; Mori, Kentaro; Tsukada, Keita; Ichinose, Aya; Yoshimura, Hidekane; Iwasaki, Satoshi; Komune, Shizuo; Usami, Shin-ichi;


アッシャー症候群の5症例
Otology Japan,24(1):39-43 2014
Author:小林 有美子; 村井 盛子; 佐藤 宏昭; 吉村 豪兼; 宇佐美 真一; 岩崎 聡;
Keywords:遺伝性難聴;


Massively Parallel DNA Sequencing Facilitates Diagnosis of Patients with Usher Syndrome Type 1
PLOS ONE,9(3) 2014
Author:Yoshimura, Hidekane; Iwasaki, Satoshi; Nishio, Shin-ya; Kumakawa, Kozo; Tono, Tetsuya; Kobayashi, Yumiko; Sato, Hiroaki; Nagai, Kyoko; Ishikawa, Kotaro; Ikezono, Tetsuo; Naito, Yasushi; Fukushima, Kunihiro; Oshikawa, Chie; Kimitsuki, Takashi; Nakanishi, Hiroshi; Usami, Shin-ichi;


Deafness Gene Expression Patterns in the Mouse Cochlea Found by Microarray Analysis
PLOS ONE,9(3) 2014
Author:Yoshimura, Hidekane; Takumi, Yutaka; Nishio, Shin-ya; Suzuki, Nobuyoshi; Iwasa, Yoh-ichiro; Usami, Shin-ichi;


Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice
ANTIOXIDANTS & REDOX SIGNALING,20(16):2606-2620 2014
Author:Tian, Geng; Sawashita, Jinko; Kubo, Hiroshi; Nishio, Shin-ya; Hashimoto, Shigenari; Suzuki, Nobuyoshi; Yoshimura, Hidekane; Tsuruoka, Mineko; Wang, Yaoyong; Liu, Yingye; Luo, Hongming; Xu, Zhe; Mori, Masayuki; Kitano, Mitsuaki; Hosoe, Kazunori; Takeda, Toshio; Usami, Shin-ichi; Higuchi, Keiichi;


当科におけるUsher症候群例,難聴遺伝子検査結果の検討
Audiology Japan,56(5):351-352 2013(Sep. 30)
Author:岸本 逸平; 篠原 尚吾; 藤原 敬三; 十名 理紗; 諸頭 三郎; 山本 輪子; 宇佐 美真一; 吉村 豪兼; 内藤 泰;


Usher症候群タイプ1における遺伝子検査と耳鼻咽喉科医の役割
Audiology Japan,56(5):369-370 2013(Sep. 30)
Author:吉村 豪兼; 岩崎 聡; 西尾 信哉; 宇佐美 真一; 熊川 孝三; 東野 哲也; 佐藤 宏昭; 長井 今日子; 石川 浩太郎; 池園 哲郎; 内藤 泰; 福島 邦博; 中西 啓;


Auditory neuropathy spectrum disorderに対する遺伝子診断の有用性および遺伝カウンセリング
Audiology Japan,56(5):371-382 2013(Sep. 30)
Author:岩佐 陽一郎; 吉村 豪兼; 宮川 麻衣子; 西尾 信哉; 工 穣; 宇佐美 真一;


An Usher syndrome type 1 patient diagnosed before the appearance of visual symptoms by MYO7A mutation analysis
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY,77(2):298-302 2013(Feb.)
Author:Yoshimura, Hidekane; Iwasaki, Satoshi; Kanda, Yukihiko; Nakanishi, Hiroshi; Murata, Toshinori; Iwasa, Yoh-ichiro; Nishio, Shin-ya; Takumi, Yutaka; Usami, Shin-ichi;


Usher症候群タイプ1の原因遺伝子と前庭機能評価についての検討
Equilibrium Research,72(6):467-471 2013
Author:吉村 豪兼; 岩崎 聡; 熊川 孝三; 小林 有美子; 佐藤 宏昭; 福島 邦博; 福岡 久邦; 塚田 景大; 工 穣; 宇佐美 真一;
Keywords:Usher syndrome; hearing loss; vestibular dysfunction; retinitis pigmentosa;


Auditory neuropathy spectrum disorderに対する遺伝子診断の有用性および遺伝カウンセリング
AUDIOLOGY JAPAN,56(5):371-372 2013
Author:岩佐 陽一郎; 吉村 豪兼; 宮川 麻衣子; 西尾 信哉; 工 穣; 宇佐美 真一;


OTOF mutation screening in Japanese severe to profound recessive hearing loss patients
BMC MEDICAL GENETICS,14 2013
Author:Iwasa, Yoh-ichiro; Nishio, Shin-ya; Yoshimura, Hidekane; Kanda, Yukihiko; Kumakawa, Kozo; Abe, Satoko; Naito, Yasushi; Nagai, Kyoko; Usami, Shin-ichi;


Usher 症候群の臨床的タイプ分類の問題点
日本耳鼻咽喉科學會會報,115(10):894-901 2012(Oct. 20)
Author:岩崎 聡; 吉村 豪兼; 武市 紀人; 佐藤 宏昭; 石川 浩太郎; 加我 君孝; 熊川 孝三; 長井 今日子; 古屋 信彦; 池園 哲郎; 中西 啓; 内藤 泰; 福島 邦博; 東野 哲也; 君付 隆; 西尾 信哉; 工 穣; 宇佐美 真一;
Keywords:アッシャー症候群; 網膜色素変性症; 感音難聴; タイプ分類;


Usher症候群の臨床的タイプ分類の問題点
日本耳鼻咽喉科学会会報,115(10):894-901 2012(Oct.)
Author:岩崎 聡; 吉村 豪兼; 武市 紀人;
Keywords:アッシャー症候群; 網膜色素変性症; 感音難聴; タイプ分類; Usher syndrome; retinitis pigmentosa; sensorineural hearing loss; type classification;


保険収載となった「先天性難聴の遺伝子診断」の現状について
Audiology Japan,55(5):459-460 2012(Sep. 30)
Author:工 穣; 岩佐 陽一郎; 吉村 豪兼; 矢野 卓也; 内藤 武彦; 宮川 麻衣子; 茂木 英明; 西尾 信哉; 宇佐美 真一;


高度・重度感音難聴患者におけるOTOF遺伝子変異解析
Audiology Japan,55(5):589-590 2012(Sep. 30)
Author:岩佐 陽一郎; 西尾 信哉; 吉村 豪兼; 宇佐美 真一; 神田 幸彦; 阿部 聡子; 熊川 孝三; 内藤 泰;


Usher 症候群の全国アンケート調査結果の検討
Otology Japan,22(1):40-46 2012(Feb. 29)
Author:吉村 豪兼; 岩崎 聡; 中西 啓; 西尾 信哉; 岩佐 陽一郎; 工 穣; 宇佐美 真一;
Keywords:難聴; 網膜色素変性症; 疫学調査;


「脳神経内科」「耳鼻咽喉科」
信州医学雑誌,60(2):97-97 2012
Author:安出 卓司; 吉村 豪兼;


The first report of bilateral retropharyngeal lymph node metastasis from papillary thyroid carcinoma and review of the literature
ACTA OTO-LARYNGOLOGICA,131(12):1341-1348 2011(Dec.)
Author:Kainuma, Kazuyuki; Kitoh, Ryosuke; Yoshimura, Hidekane; Usami, Shin-ichi;


耳下腺内に多発した顔面神経鞘腫例
耳鼻咽喉科臨床,104(11):797-801 2011(Nov. 01)
Author:岩佐 陽一郎; 坂口 正範; 吉村 豪兼; 宇佐美 真一;
Keywords:multiple facial schwannoma; parotid gland; facial nerve;


口蓋扁桃摘出術が有効であったPFAPA症候群例 : 習慣性扁桃炎との相違を中心に
耳鼻咽喉科臨床,104(11):825-828 2011(Nov. 01)
Author:吉村 豪兼; 鬼頭 良輔; 宇佐美 真一;
Keywords:PFAPA syndrome; chronic tonsillitis; tonsillectomy;


先進医療「先天性難聴の遺伝子診断」の現状
Audiology Japan,54(5):595-596 2011(Sep. 30)
Author:工 穣; 岩佐 陽一郎; 吉村 豪兼; 矢野 卓也; 内藤 武彦; 宮川 麻衣子; 茂木 英明; 西尾 信哉; 宇佐美 真一;


めまいを主訴とした多発性硬化症の1例
Equilibrium research,70(4):245-249 2011(Aug. 01)
Author:吉村 豪兼; 坂口 正範; 福岡 久邦; 塚田 景大; 宇佐美 真一;
Keywords:vertigo; facial palsy; MRI; multiple sclerosis;


下咽頭混合型小細胞癌と考えられた1例
耳鼻咽喉科臨床,104(3):199-203 2011(Mar. 01)
Author:吉村 豪兼; 海沼 和幸; 宇佐美 真一;
Keywords:combined small cell carcinoma; hypopharynx; surgery;


耳下腺内に多発した顔面神経鞘腫例
耳鼻咽喉科臨床,104(11):797-801 2011
Author:岩佐 陽一郎; 坂口 正範; 吉村 豪兼; 宇佐美 真一;
Keywords:multiple facial schwannoma; parotid gland; facial nerve;


口蓋扁桃摘出術が有効であったPFAPA症候群例  ‐習慣性扁桃炎との相違を中心に‐:―習慣性扁桃炎との相違を中心に―
耳鼻咽喉科臨床,104(11):825-828 2011
Author:吉村 豪兼; 鬼頭 良輔; 宇佐美 真一;
Keywords:PFAPA syndrome; chronic tonsillitis; tonsillectomy;


講演・口頭発表等
遅発性内リンパ水腫診断における3T-MRIの有用性
Equilibrium Research 75 5 406 2016(Oct.)
Presenter:岩佐 陽一郎, 塚田 景大, 森 健太郎, 吉村 豪兼, 福岡 久邦, 宇佐美 真一


全エキソーム解析で見出された新規難聴原因遺伝子と考えられるCDC14A遺伝子変異症例
Otology Japan 26 4 260 2016(Sep.)
Presenter:吉村 豪兼, 宇佐美 真一


当科における内耳造影MRIによる内リンパ水腫の同定について
Otology Japan 26 4 285 2016(Sep.)
Presenter:塚田 景大, 岩佐 陽一郎, 吉村 豪兼, 小林 正史, 北野 友裕, 宇佐美 真一


好酸球性中耳炎に対する人工内耳埋め込み術の一例
Otology Japan 26 4 549 2016(Sep.)
Presenter:古舘 佐起子, 鈴木 伸嘉, 吉村 豪兼, 岩崎 聡


3T-MRIにて診断された遅発性内リンパ水腫症例の検討
耳鼻咽喉科臨床 補冊 補冊146 90 2016(Jun.)
Presenter:岩佐 陽一郎, 塚田 景大, 森 健太郎, 吉村 豪兼, 宇佐美 真一


当科における指定難病(若年発症型両側性感音難聴、遅発性内リンパ水腫、アッシャー症候群)の現状と問題点
日本耳鼻咽喉科学会会報 119 4 577 2016(Apr.)
Presenter:塚田 景大, 宮川 麻衣子, 吉村 豪兼, 岩佐 陽一郎, 宇佐美 真一

研究費
科学研究費補助金(研究代表者)
2019 - 2022 , 難聴の遺伝子治療に向けたAAVセロタイプ特性に関する研究 , 若手研究
2016 - 2018 , Usher症候群に関する遺伝的背景に関する研究 , 若手研究(B)
2013 - 2015 , 蝸牛の回転ごとに発現する遺伝子スプライシングバリアントの網羅的解析 , 挑戦的萌芽研究