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下平 滋隆  シモダイラ シゲタカ

教員組織電話番号
教育組織医学部附属病院 先端細胞治療センターFAX番号
職名特任教授メールアドレス
住所ホームページURL

更新日:2020/10/26

プロフィール

兼担研究科・学部
台湾高雄医学大学医学系大学院
金沢医科大学 再生医療学
研究分野
がん樹状細胞療法
再生医療
キーワード:細胞治療 , 再生医療 , 腫瘍免疫 , 樹状細胞療法 , がん免疫療法 , 橋渡し研究 , 精密医療
現在の研究課題
再生医療
キーワード:再生医療 , 2004-
樹状細胞療法
キーワード:がん免疫療法 , 樹状細胞 , 2008-2018 , がん樹状細胞療法の安全性・有効性に関する研究
所属学会
所属学会
国際幹細胞研究会議
英国王立医学会
日本血液学会
日本再生医療学会
日本癌治療学会
日本内科学会

所属学会役職担当
細胞治療認定管理師制度審議会 , 細胞治療認定管理師試験委員長
日本輸血・細胞治療学会
学歴
出身大学院
1997 , 信州大学大学院医学研究科

出身学校・専攻等(大学院を除く)
1990 , 信州大学医学部医学科

取得学位
博士(医学) , 信州大学
受賞学術賞
2108 , A Lifetime Achievement by Marquis Who's Who 2018
2019 , Who's Who in the World® 2019ー2020
2019 , 2019 国際高雄がんシンポジウム 講演賞
2017 , Who's Who in the World® 2018
2017 , 北辰同窓会賞
2017 , Who's Who in the World® 2017
2017 , A Lifetime Achievement by Marquis Who's Who 2017
2016 , 2017 Who's Who in Asia® , Marquis Who's Who
2016 , 全台湾小児アレルギー喘息免疫アカデミー表彰 , Dendritic cell–based Cancer Immunotherapy
2016 , The Best Doctors in Japan 2016-2017
2016 , 2000 Outstanding Intellectuals of the 21th Century
2016 , TOP100 Professionals‐2016
2016 , Cambridge Certificate for Outstanding Medical Achievement
2015 , Who's Who in the World® 2016 , Marquis Who's Who
2014 , The Best Doctors in Japan 2014-2015
2012 , 感謝状
2010 , 日本ロボット学会実用化技術賞 「細胞自動培養システム」
研究職歴等
研究職歴
2016- , 金沢医科大学 主任教授

留学歴
1999-2001 , 米国 南カリフォルニア大学(分子微生物・免疫学講座 研究員)

研究活動業績

研究業績(著書・
発表論文等)
著書
Dendritic Cell-Based Cancer Immunotherapy Targeting Wilms’ Tumor 1 for Pediatric Cancer.
Codon Publications (Brisbane) , van den Heuvel-Eibrink MM (ed.) Wilms Tumor , :Chapter 8 2016(Mar.)
Author:Shimodaira S, Hirabayashi K, Yanagisawa R, Higuchi Y, Sano K, Koizumi T.


安全な輸血療法ガイド
日本輸血・細胞治療学会 2012(Mar. 31)
Author:藤井康彦,下平滋隆,田崎哲典,星順隆,浅井隆善,松﨑浩史


院内製剤による輸血・細胞医療の安全性に関する検討
岩橋印刷株式会社 , 血液事業の課題.北海道輸血シンポジウム 2011(Apr.)
Author:柳沢龍,下平滋隆


樹状細胞療法の実際
文光堂 , 1冊でわかる皮膚がん 斎田俊明,宮地良樹,清水 宏 編 , :253-255 2011(Feb. 01)
Author:下平滋隆


輸血副作用対応ガイド
日本輸血・細胞治療学会 2011(Jan. 31)
Author:藤井康彦,下平滋隆,田崎哲典,星順隆,浅井隆善,松﨑浩史


論文
In Vivo Administration of Recombinant Human Granulocyte Colony-Stimulating Factor Increases the Immune Effectiveness of Dendritic Cell-Based Cancer Vaccination.
Vaccines,7(3):120 2019(Sep. 19)
Author:Shimodaira S, Yanagisawa R, Koya T, Hirabayashi K, Higuchi Y, Sakamoto S, Togi T, Kato T Jr, Kobayashi T, Koizumi T, Koido S, and Sugiyama H;


Investigation of factors associated with allergic transfusion reaction due to platelet transfusion and the efficacy of platelets resuspended in BRS-A in adult patients.
,Transfusion 2019(Sep. 18)
Author:Yamanaka M, Yanagisawa R, Kojima S, Nakazawa H, Shimodaira S;


Predicted Markers of Overall Survival in Pancreatic Cancer Patients Receiving Dendritic Cell Vaccinations Targeting WT1
ONCOLOGY,97(3):135-148 2019
Author:Ito, Zensho; Kan, Shin; Bito, Tsuuse; Horiuchi, Sankichi; Akasu, Takafumi; Yoshida, Sayumi; Kajihara, Mikio; Hokari, Atsushi; Saruta, Masayuki; Yoshida, Noriyuki; Kobayashi, Masanori; Ohkusa, Toshifumi; Shimodaira, Shigetaka; Okamoto, Masato; Sugiyama, Haruo; Koido, Shigeo;


Comparison of administration of platelet concentrates suspended in M-sol or BRS-A for pediatric patients
TRANSFUSION,58(12):2952-2958 2018(Dec.)
Author:Kojima, Shunsuke; Yanagisawa, Ryu; Tanaka, Miyuki; Nakazawa, Yozo; Shimodaira, Shigetaka;


Feasibility and immune response of WT1 peptide vaccination in combination with OK-432 for paediatric solid tumors
Anticancer Res,38(4):2227 2018
Author:Hirabayashi K, Yanagisawa R, Saito S, Higuchi Y, Koya T, Sano K, Koido S, Okamoto M, Sugiyama H, Nakazawa Y, Shimodaira S


WT1-pulsed dendritic cell vaccine combined with chemotherapy for resected pancreatic cancer in a phase I study
Anticancer Res,38(4):2217 2018
Author:Yanagisawa R, Koizumi T, Koya T, Sano K, Koido S, Nagai K, Kobayashi M, Okamoto M, Sugiyama H, Shimodaira S


Prognostic significance of Wilms' tumor 1 expression in patients with pancreatic ductal adenocarcinoma
Oncol Lett,16(2):2682 2018
Author:Kanai T, Ito Z, Oji Y, Suka M, Nishida S, Takakura K, Kajihara M, Saruta M, Fujioka S, Misawa T, Akiba T, Yanagisawa H, Shimodaira S, Okamoto M, Sugiyama H, Koido S


Evaluation of Gelatin-Hybridized Chelate-Setting Calcium Phosphate Cements in Alveolar Bone Defects of Canine Mandible
Biomed J Sci & Tech Res,3(4) 2018
Author:Matsumoto G, Sugita Y, Kubo K, Yoshida W, Maeda H, Aizawa M, Shimodaira S, Kinoshita Y


Administration of platelet concentrates suspended in bicarbonated Ringer's solution in children who had platelet transfusion reactions
Vox Sang,113(2):128 2018
Author:Kobayashi J, Yanagisawa R, Ono T, Tatsuzawa Y, Tokutake Y, Kubota N, Hidaka E, Sakashita K, Kojima S, Shimodaira S, Nakamura T


Interferon-alpha-inducible Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas Ligand Pathway-mediated Killer Activity
SCIENTIFIC REPORTS,7:- 2017
Author:Koya, Terutsugu; Yanagisawa, Ryu; Higuchi, Yumiko; Sano, Kenji; Shimodaira, Shigetaka;


Significance of Wilms' tumor 1 antigen as a cancer vaccine for pancreatic cancer
Discov Med,24(130):41 2017
Author:Koido S, Okamoto M, Kobayashi M, Shimodaira S, Sugiyama H


私立大学医学部のResilienceから学ぶこと
信州医学雑誌,65(1):1-2 2017
Author:下平 滋隆;


Clinical effect and immunological response in patients with advanced malignant glioma treated with WT1-pulsed dendritic cell-based immunotherapy: A report of two cases
Interdisciplinary Neurosurgery,9:24 2017
Author:Sakai K, Shimodaira S, Maejima S, Sano K, Higuchi Y, Koya T, Sugiyama H, Hongo K


Wilms' tumor 1 (WT1)-targeted cancer vaccines to extend survival for patients with pancreatic cancer.
Immunotherapy,8(11):1309-1320 2016(Nov.)
Author:Koido S, Okamoto M, Shimodaira S, Sugiyama H.


Wilms' tumor 1 (WT1)-targeted cancer vaccines to extend survival for patients with pancreatic cancer
IMMUNOTHERAPY,8(11):1309-1320 2016(Nov.)
Author:Koido, Shigeo; Okamoto, Masato; Shimodaira, Shigetaka; Sugiyama, Haruo;


Lung adenocarcinoma may be a more susceptive subtype to a dendritic cell-based cancer vaccine than other subtypes of non-small cell lung cancers: a multicenter retrospective analysis
CANCER IMMUNOLOGY IMMUNOTHERAPY,65(9):1099-1111 2016(Sep.)
Author:Takahashi, Hidenori; Shimodaira, Shigetaka; Ogasawara, Masahiro; Ota, Shuichi; Kobayashi, Masanori; Abe, Hirofumi; Morita, Yuji; Nagai, Kazuhiro; Tsujitani, Shunichi; Okamoto, Masato; Suzuki, Yukio; Nakanishi, Yoichi; Yonemitsu, Yoshikazu; Japanese Soc Immunotherapy Cell;


Lung adenocarcinoma may be a more susceptive subtype to a dendritic cell-based cancer vaccine than other subtypes of non-small cell lung cancers: a multicenter retrospective analysis.
Cancer Immunol Immunother,65(9):1099-111 2016(Sep.)
Author:Takahashi H, Shimodaira S, Ogasawara M, Ota S, Kobayashi M, Abe H, Morita Y, Nagai K, Tsujitani S, Okamoto M, Suzuki Y, Nakanishi Y, Yonemitsu Y; DC Vaccine Study Group at the Japanese Society of Immunotherapy and Cell Therapy..


Transfusion-related acute lung injury in an infant.
Pediatr Int,58(6):543-4 2016(Jun.)
Author:Yanagisawa R, Takeuchi K, Kurata T, Sakashita K, Shimodaira S, Ishii E.


Transfusion-related acute lung injury in an infant
PEDIATRICS INTERNATIONAL,58(6):543-544 2016(Jun.)
Author:Yanagisawa, Ryu; Takeuchi, Kouichi; Kurata, Takashi; Sakashita, Kazuo; Shimodaira, Shigetaka; Ishii, Eizaburo;


Advances in inducing adaptive immunity using cell-based cancer vaccines: Clinical applications in pancreatic cancer.
World J Gastroenterol,22(18):4446-58 2016(May)
Author:Kajihara M, Takakura K, Kanai T, Ito Z, Matsumoto Y, Shimodaira S, Okamoto M, Ohkusa T, Koido S.


Dendritic cell-based cancer immunotherapy for colorectal cancer.
World J Gastroenterol,22(17):4275-86 2016(May)
Author:Kajihara M, Takakura K, Kanai T, Ito Z, Saito K, Takami S, Shimodaira S, Okamoto M, Ohkusa T, Koido S.


Intrathecal donor lymphocyte infusion for isolated leukemia relapse in the central nervous system following allogeneic stem cell transplantation: a case report and literature review
INTERNATIONAL JOURNAL OF HEMATOLOGY,103(1):107-111 2016(Jan.)
Author:Yanagisawa, Ryu; Nakazawa, Yozo; Sakashita, Kazuo; Saito, Shoji; Tanaka, Miyuki; Shiohara, Masaaki; Shimodaira, Shigetaka; Koike, Kenichi;


Intrathecal donor lymphocyte infusion for isolated leukemia relapse in the central nervous system following allogeneic stem cell transplantation: a case report and literature review.
Int J Hematol,103(1):107-11 2016(Jan.)
Author:Yanagisawa R, Nakazawa Y, Sakashita K, Saito S, Tanaka M, Shiohara M, Shimodaira S, Koike K.


小児同種骨髄移植後possible TRALI
日本輸血細胞治療学会誌,62(3):439-440 2016
Author:柳沢 龍; 村田 マサ子; 坂下 一夫; 下平 滋隆; 石井 栄三郎;
Keywords:輸血関連急性肺障害; 敗血症; 造血幹細胞移植; 小児血液悪性疾患; 白血病;


Wilms Tumor Chapter 8
信州医学雑誌,64(5):323-323 2016
Author:下平 滋隆;


Advances in inducing adaptive immunity using cell-based cancer vaccines: clinical applications in pancreatic cancer
WORLD JOURNAL OF GASTROENTEROLOGY,22(18):4446-4458 2016
Author:Kajihara, Mikio; Takakura, Kazuki; Kanai, Tomoya; Ito, Zensho; Matsumoto, Yoshihiro; Shimodaira, Shigetaka; Okamoto, Masato; Ohkusa, Toshifumi; Koido, Shigeo;


Dendritic cell-based cancer immunotherapy for colorectal cancer
WORLD JOURNAL OF GASTROENTEROLOGY,22(17):4275-4286 2016
Author:Kajihara, Mikio; Takakura, Kazuki; Kanai, Tomoya; Ito, Zensho; Saito, Keisuke; Takami, Shinichiro; Shimodaira, Shigetaka; Okamoto, Masato; Ohkusa, Toshifumi; Koido, Shigeo;


【移植医療を支える臨床検査】 移植医療を支える臨床検査室・臨床検査技師
臨床検査,59(13):1470-1475 2015(Dec.)
Author:下平滋隆


Dendritic Cell-Based Adjuvant Vaccination Targeting Wilms' Tumor 1 in Patients with Advanced Colorectal Cancer.
Vaccines (Basel),3(4):1004-18 2015(Dec.)
Author:Shimodaira S, Sano K, Hirabayashi K, Koya T, Higuchi Y, Mizuno Y, Yamaoka N, Yuzawa M, Kobayashi T, Ito K, Koizumi T.


Efficacy of Erythropoietin-Beta Injections During Autologous Blood Donation Before Spinal Deformity Surgery in Children and Teenagers.
Spine (Phila Pa 1976),40(21):E1144-9 2015(Nov.)
Author:Ikegami S, Takahashi J, Kuraishi S, Shimizu M, Futatsugi T, Uehara M, Horiuchi K, Shimodaira S, Kato H.


Repeated exposure rather than the total volume of transfused components may influence the incidence of allergic transfusion reactions.
Transfusion,55(11):2576-81 2015(Nov.)
Author:Kato H, Nakayama T, Uruma M, Okuyama Y, Handa M, Tomiyama Y, Shimodaira S, Takamoto S.


Dendritic cell-based immunotherapy targeting Wilms' tumor 1 in patients with recurrent malignant glioma.
J Neurosurg,123(4):989-97 2015(Oct.)
Author:Sakai K, Shimodaira S, Maejima S, Udagawa N, Sano K, Higuchi Y, Koya T, Ochiai T, Koide M, Uehara S, Nakamura M, Sugiyama H, Yonemitsu Y, Okamoto M, Hongo K.


Rh血液型表記に関する問題 本学会関東甲信越支部アンケート調査結果より
日本輸血細胞治療学会誌,61(3):427-432 2015(Jun.)
Author:長谷川雄一, 浅井隆善, 稲葉頌一, 岩尾憲明, 大坂顯通, 奥山美樹, 岸野光司, 下平滋隆, 高橋孝喜, 田崎哲典, 中島一格, 半田誠, 布施一郎, 牧野茂義, 室井一男


Safety and tolerability of allogeneic dendritic cell vaccination with induction of Wilms tumor 1-specific T cells in a pediatric donor and pediatric patient with relapsed leukemia: a case report and review of the literature.
Cytotherapy,17(3):330-5 2015(Mar.)
Author:Saito S, Yanagisawa R, Yoshikawa K, Higuchi Y, Koya T, Yoshizawa K, Tanaka M, Sakashita K, Kobayashi T, Kurata T, Hirabayashi K, Nakazawa Y, Shiohara M, Yonemitsu Y, Okamoto M, Sugiyama H, Koike K, Shimodaira S.


Mobile ICUおよびair transportを利用した人工呼吸器管理下の海外患者搬送
日本集中治療医学会雑誌,22(1):47-48 2015(Jan.)
Author:道永祐希, 望月憲招, 下平滋隆, 堂籠博, 岡元和文


Smoking influences the yield of dendritic cells for cancer immunotherapy
Pharmaceutical Regulatory Affairs,4(1):133 2015
Author:Shimodaira, S; Higuchi, Y; Koya, T; Kobayashi, T; Yanagisawa, R; Hirabayashi, K; Ito, K; Koizumi, T; Maejima, S; Udagawa, N


Successful cord blood transplantation after repeated transfusions of unmobilized neutrophils in addition to antifungal treatment in an infantwith chronic granulomatous disease complicated byinvasive pulmonary aspergillosis.
Transfusion,54(3):516-21. 2014
Author:Shigemura T, Nakazawa Y, Yoshikawa K, Hirabayashi K, Saito S, Kobayashi N, Sakashita K, Shiohara M, Wada T, Shimodaira S, Agematsu K, Koike K.


Incidence of transfusion-related adverse reactions per patient reflects the potential risk of transfusion therapy in Japan.
Am J Clin Pathol,140(2):219-24. 2013
Author:Kato H, Uruma M, Okuyama Y, Fujita H, Handa M, Tomiyama Y, Shimodaira S, Kurata Y, Takamoto S.


Dendritic cell-based immunotherapy targeting synthesized peptides for advanced biliary tract cancer.
J Gastrointest Surg,17(9):1609-17. 2013
Author:Kobayashi M, Sakabe T, Abe H, Tanii M, Takahashi H, Chiba A, Yanagida E, Shibamoto Y, Ogasawara M, Tsujitani S, Koido S, Nagai K, Shimodaira S, Okamoto M, Yonemitsu Y, Suzuki N, Nagaya M; DC-vaccine study group at the Japan Society of Innovative Cell Therapy (J-SICT).


Immunochemoradiotherapy for patients with oral squamous cell carcinoma: augmentation of OK-432-induced helper T cell 1 responseby 5-FU and X-ray irradiation.
Neoplasia,15(7):805-14. 2013
Author:Tano T, Okamoto M, Kan S, Bando T, Goda H, Nakashiro K, Shimodaira S, Koido S, Homma S, Fujita T, Sato M, Yamashita N, Hamakawa H, Kawakami Y. 


Prognostic impact of expression of Bcl-2 and Bax genes in circulating immune cells derived from patients with head and neck carcinoma.
Neoplasia,15(3):305-14. 2013
Author:Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Koido S, Homma S, Sato M, Fujita T, Kawakami Y, Hamakawa H.


Replaced platelet concentrates containinga new additive solution, M-sol: safety and efficacy for pediatric patients. Transfusion.
53,9:2053-60. 2013
Author:Yanagisawa R, Shimodaira S, Kojima S, Nakasone N, Ishikawa S, Momose K, Honda T, Yoshikawa K, Saito S, Tanaka M, Nakazawa Y, Sakashita K, Shiohara M, Akino M, Hirayama J, Azuma H, Koike K.


Impact of dendriticcell vaccines pulsed with Wilms'tumour-1 peptide antigen on the survival of patients with advanced non-small cell lung cancers.
Eur J Cancer,49(4):852-9. 2013
Author:Takahashi H, Okamoto M, Shimodaira S, Tsujitani S, Nagaya M, Ishidao T, Kishimoto J, Yonemitsu Y; DC-vaccine study group at the Japan Society of Innovative Cell Therapy (J-SICT).


Clinical and immunologic evaluation of dendritic cell-based immunotherapy in combination with gemcitabine and/or S-1 in patients with advanced pancreatic carcinoma.
Pancreas,41:205 2012
Author:Kimura Y, Tsukada J, Tomoda T, Takahashi H, Imai K, Shimamura K, Sunamura M, Yonemitsu Y, Shimodaira S, Koido S, Homma S, Okamoto M


Growth inhibition and apoptosis by an active component of OK-432, a streptococcal agent, via Toll-like receptor 4 in human head and neck cancer cell lines.
Oral Oncol,48:678 2012
Author:Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Yamashita N, Kawakami Y, Hamakawa H


細胞自動培養システム
日本ロボット学会誌,29:43∼44 2011(Jan.)
Author:中嶋 勝己,上田 澄広,櫻井. 隆,蓮沼 仁志,羽畑. 修,金澤 秀和,脇谷 滋之,田原 秀晃,下平 滋隆,植村 壽公


置換液M-sol を用いた置換血小板(R-PC)調製のプロセスバリデーションに関する検討
日本輸血・細胞治療学会誌,57(5):379-385 2011
Author:小嶋俊介,柳沢龍, 石川伸介,中曽根允彦,中澤希世子,長谷川康久,小林孝至,平山順一,秋野光明,東寛,下平滋隆


The clinical characteristics of CD7+ CD56+ acute myeloid leukemias other than M0.
Int J Hematol,91:303-9 2010
Author:Suzuki R, Ohtake S, Takeuchi J, Nagai M, Kodera Y, Hamaguchi M, Miyawaki S, Karasuno T, Shimodaira S, Ohno R, Nakamura S, Naoe T


The usefulness of pathogen inactivation during an outbreak of the new strain of influenza (H1N1).
TransfusMed Rev,24:151-2 2010
Author:Narimatsu H, Yuji K, Shimodaira S, Kami M


がんの免疫細胞療法の進歩
信州医学雑誌,55(3):113-120 2007(Jun.)
Keywords:cell transfer immunotherapy, regulatory T cell, cytokine, dendritic cell, リンパ球移入療法, 制御性T細胞, サイトカイン, 樹状細胞


Therapeutic angiogenesis by bone marrow implantation for critical hand ischemia in patients with peripheral arterial disease: a pilot study
CURRENT MEDICAL RESEARCH AND OPINION,22(4):793-798 2006
Author:Koshikawa, M; Shimodaira, S; Yoshioka, T; Kasai, H; Watanabe, N; Wada, Y; Seto, T; Fukui, D; Amano, J; Ikeda, U


四肢虚血性疾患に対する自己骨髄細胞移植とその臨床効果
治療学,39:101-104 2005
Author:福井大祐,天野 純,下平滋隆,池田宇一


四肢虚血性疾患に対する自己骨髄細胞移植とその臨床効果
治療学,39:765-768 2005
Author:福井大祐,天野 純,下平滋隆,池田宇一


TACT (Therapeutic Angiogenesis by Cell Transplantation)
脈管学,45:161-165 2005
Author:吉岡 徹,高橋将文,笠井宏樹,福井大祐,下平慈隆,池田宇一


High-dose melphalan followed by autologous stem cell support in primary systemic AL amyloidosis with multiple organ involvement
Intern Med,4:484-489 2005
Author:Shimojima Y, Matsuda M, Ishii W, Koyama J, Yamamoto K, Shimodaira S, Sakashita K, Koike K, Ikeda S


Significance of chemokine receptor expression in aggressive NK cell leukemia
Leukemia,19:1169-1174 2005
Author:Makishima H, Ito T, Asano N, Nakazawa H, Shimodaira S, Kamijo Y, Nakazawa Y, Suzuki T, Kobayashi H, Kiyosawa K, Ishida F


Effect of Helicobacter pylori eradication on ongoing mutation of immunoglobulin genes in gastric MALT lymphoma
British Journal of Cancer,92:312-319 2005
Author:K Fujimori, S Shimodaira, T Akamatsu, K Furihata, T Katsuyama, S Hosaka


末梢性血管疾患への血管再生医療
日本移植学会雑誌,39:509-514 2004
Author:笠井宏樹,福井大祐,下平滋隆,木下 修,天野 純,池田宇一


Hepatitis C virus induces a mutator phenotype: Enhancedmutations of immunoglobulin and protooncogenes
Proc Natl Acad Sci USA,101:4262-4267 2004
Author:Machida K, Cheng KT, Sung VM, Shimodaira S, Lindsay KL, Levine AL, Lai MY, Lai MMC


Expression levels of CXCR1 and CCR5 on natural killer (NK) cells in aggressive NK cell leukemia and chronic NK cell lymphocytosis.
BLOOD,102(11):604A-604A 2003
Author:Makishima, H; Ishida, F; Ito, T; Shimodaira, S; Kiyosawa, K


Treatment of HCV-related mantle-cell lymphoma with ribavirin and pegylated interferon Alfa
N Engl J Med,349:2078-2079 2003
Author:Levine AM, Shimodaira S, Lai MM


Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: the apoptotic effects of virus infection
J Virol,77:2134-2146 2003
Author:Sung VM, Shimodaira S, Doughty AL, Picchio GR, Can H, Yen TS, Lindsay KL, Levine AM, Lai MM


自家末梢血幹細胞移植を施行した多発性骨髄腫7例の検討
長野県医学会雑誌,32:20-22 2002
Author:伊藤俊朗,北野喜良,石田文宏,下平滋隆,牧島秀樹,百瀬佳代子,清澤研道


Competitive reverse transcription-polymerase chain reaction assay for quantification of human multidrug resistance 1 (MDR1) gene expression in fresh leukemic cells
JOURNAL OF LABORATORY AND CLINICAL MEDICINE,135(2):199-209 2000
Author:Kobayashi, H; Takemura, Y; Kawai, Y; Miyachi, H; Kawabata, M; Matsumura, T; Yamashita, T; Mori, S; Furihata, K; Shimodaira, S; Motoyoshi, K; Hotta, T; Sekiguchi, S; Ando, Y; Watanabe, K


Development ofhigh speed skating rink by the control of crystallographic plane of ice
JOURNAL OF JAPANESE SOCIETY OF TRIBOLOGISTS,45(1):72-78 2000
Author:Tusima, K; Yuki, M; Kiuchi, T; Shimodaira, S


Clonal identity of nodular lymphocyte-predominant Hodgkin's disease and T-cell-rich B-cell lymphoma
NEW ENGLAND JOURNAL OF MEDICINE,343(15):1124-1125 2000
Author:Shimodaira, S; Hidaka, E; Katsuyama, T


Skewed T cell receptor repertoires with oligoclonal profiles in patients with CD8-positive T cell lymphoproliferative disease of granular lymphocytes.
BLOOD,96(11):545 - 2000
Author:Makishima, H; Ishida, F; Ito, T; Ota, M; Katsuyama, Y; Ueno, M; Shimodaira, S; Kitano, K; Kiyosawa, K


Genetic linkage of Kozak sequence polymorphism of the platelet glycoprotein Ib alpha with human platelet antigen-2 and variable number of tandem repeats polymorphism, and its relationship with coronary artery disease
BRITISH JOURNAL OF HAEMATOLOGY,111(4):1247-1249 2000
Author:Ishida, F; Ito, T; Takei, M; Shimodaira, S; Kitano, K; Kiyosawa, K


Elliptocytosis in myelodysplastic syndrome associated with translocation (1;5)(p10;q10) and deletion of 20q
CANCER GENETICS AND CYTOGENETICS,108(2):162-165 1999
Author:Ishida, F; Shimodaira, S; Kobayashi, H; Saito, H; Kako, M; Kanzaki, A; Yawata, Y; Kitano, K; Kiyosawa, K


Abnormal proliferation of CD4(-) CD8(+) gamma delta(+) T cells with chromosome 6 anomaly: Roleof fas ligand expression in spontaneous regression of the cells
AMERICAN JOURNAL OF HEMATOLOGY,60(4):305-308 1999
Author:Ichikawa, N; Kitano, K; Ito, T; Nakazawa, T; Shimodaira, S; Ishida, F; Kiyosawa, K


Acute myelogenous leukemia with a t(2;17;4)(p13;q21;p16) aberration: Effective treatment with all-trans retinoic acid and granulocyte colony-stimulating factor
INTERNAL MEDICINE,38(2):150-154 1999
Author:Shimodaira, S; Kitano, K; Nishizawa, Y; Ichikawa, N; Ishida, F; Kamino, I; Matsui, H; Kiyosawa, K


Distinct association of HLA class-I and-II antigens with idiopathic thrombocytopenic purpura.
BLOOD,94(10):66 - 1999
Author:Ueno, M; Ishida, F; Katsuyama, Y; Shimodaira, S; Saito, S; Ota, M;Kitano, K; Kiyosawa, K


Liver cirrhosis with marked thrombocytopenia and highly elevated serum thrombopoietin levels
INTERNATIONAL JOURNAL OF HEMATOLOGY,70(1):52-55 1999
Author:Kitano, K; Shimodaira, S; Ito, T; Ichikawa, N; Kodaira, H;Kohara, Y; Ueno, M; Tahara, T; Kato, T; Ishida, F; Kiyosawa, K


Polymorphisms of platelet membrane glycoprotein Ib alpha and plasma von Willebrand factor antigen in coronary artery disease
INTERNATIONAL JOURNAL OF HEMATOLOGY,70(1):47-51 1999
Author:Ito, T; Ishida, F; Shimodaira, S; Kitano, K


CD56(+) acute myeloid leukemia with monosomy 7
INTERNATIONAL JOURNAL OF HEMATOLOGY,69(3):211-212 1999
Author:Shimodaira, S; Narita, A; Kobayashi, H; Aoki, K; Saito, H; Kiyosawa, K


Immunoglobulinheavy chain gene sequences and treatment outcome for Helicobacter pylori in gastric MALT lymphomas.
GASTROENTEROLOGY,114(4):G2653 - 1998
Author:Miyabayashi, H; Fujimori, K; Shimodaira, S; Akamatsu, T; Furihata, K; Kiyosawa, K; Katsuyama, T


Associations between polymorphism of platelet membrane glycoprotein Ib alpha, plasma von Willebrand factor antigen and coronary artery disease.
BLOOD,92(10):773 - 1998
Author:Ito, T; Ishida, F; Shimodaira, S; Takei, M; Kitano, K; Kiyosawa, K


Changes in serum thrombopoietin levels after splenectomy
ACTA HAEMATOLOGICA,100(3):137-141 1998
Author:Ichikawa, N; Kitano, K; Shimodaira, S; Ishida, F; Ito, T; Kajikawa, S; Tahara, T; Kato, T; Kiyosawa, K


Resistance to activated protein C and Arg 506 Gln factor V mutation are uncommon in eastern Asian populations
ACTA HAEMATOLOGICA,98(1):22-25 1997
Author:Kodaira, H; Ishida, F; Shimodaira, S; Takamiya, O; Furihata, K; Kitano, K


Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia
LEUKEMIA,11(9):1447-1452 1997
Author:Kiyoi, H; Naoe, T; Yokota, S; Nakao, M; Minami, S; Kuriyama, K; Takeshita, A; Saito, K; Hasegawa, S; Shimodaira, S; Tamura, J; Shimazaki, C; Matsue, K; Kobayashi, H; Arima, N; Suzuki, R; Morishita, H; Saito, H; Ueda, R; Ohno, R


2-bromopropane-induced hypoplasia of bone marrow in male rats
JOURNAL OF OCCUPATIONALHEALTH,39(3):228-233 1997
Author:Nakajima, T; Shimodaira, S; Ichihara, G; Asaeda, N; Kumazawa, T; Iwai, H; Ichikawa, I; Kamijima, M; Yu, XZ; Xie, ZL; Kondo, H; Takeuchi, Y


Histopathologic findings of bone marrow induced by 2-bromopropane in male rats
JOURNAL OF OCCUPATIONAL HEALTH,39(2):81-82 1997
Author:Nakajima, T; Shimodaira, S; Ichihara, G; Asaeda, N; Kumazawa, T; Iwai, H; Ichikawa, I; Kamijima, M; Yu, XZ; Xie, ZL; Kondo, H; Takeuchi, Y


Eosinophilia associated with clonal T-cell proliferation
LEUKEMIA&LYMPHOMA,27(3-4):335-342 1997
Author:Kitano, K; Ichikawa, N; Shimodaira, S; Ito, T; Ishida, F; Kiyosawa, K


Serum thrombopoietin levels during the long-term clinical course ofhaemophiliacs with hepatitis C virus and HIV-1 CO-infection who died of hepatic failure and AIDS.
BLOOD,90(10):3089-3089 1997
Author:Kitano, K; Shimodaira, S; Ichikawa, N; Ishida, F; Ito, T; Tahara, T; Kato, T; Kiyosawa, K


Delayed and low elevation of serum thrombopoietin levels followed by slight thrombocytosis in splenectomised patients with liver cirrhosis.
BLOOD,90(10):3085-3085 1997
Author:Ichikawa, N; Kitano, K; Shimodaira, S; Ishida, F; Ito, T; Tahara, T; Kato, T; Kiyosawa, K


Eosinophilia associated with proliferation of CD3(+)4(-)8(-) alpha beta(+) T cells with chromosome 16 anomalies
BRITISH JOURNAL OF HAEMATOLOGY,92(2):315-317 1996
Author:Kitano, K; Ichikawa, N; Mahbub, B; Ueno, M; Ito, T; Shimodaira, S; Kodaira, H; Ishida, F; Kobayashi, H; Saito, H; Okubo, Y; Enokihara, H; Kiyosawa, K


Serum thrombopoietin (c-mpl ligand) levels in patients with liver cirrhosis
BRITISH JOURNAL OF HAEMATOLOGY,93:1033-1033 1996
Author:Kitano, K; Shimodaira, S; Ishida, F; Ichikawa, N; Kodaira, H; Ito, T; Tahara, T; Kato, T; Kiyosawa, K


Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anemia and idiopathic thrombocytopenic purpura.
EXPERIMENTAL HEMATOLOGY,24(9):428-428 1996
Author:Ichikawa, N; Ishida, F; Shimodaira, S; Ito, T; Tahara, T; Kato, T; Kitano, K


Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenic purpura
THROMBOSIS AND HAEMOSTASIS,76(2):156-160 1996
Author:Ichikawa, N; Ishida, F; Shimodaira, S; Tahara, T; Kato, T; Kitano, K


Serum thrombopoietin (c-Mpl ligand) levels in patients with liver cirrhosis
THROMBOSIS AND HAEMOSTASIS,76(4):545-548 1996
Author:Shimodaira, S; Ishida, F; Ichikawa, N; Tahara, T; Kato, T; Kodaira, H; Ito, T; Tanaka, E; Sodeyama, T; Kiyosawa, K; Kitano, K


The detection of clonal proliferation in granular lymphocyte-proliferative disorders of natural killer cell lineage.
Br J Haematol,90(3):578-584 1995
Author:48. Shimodaira S, Ishida F, Kobayashi H, Mahbub B, Kawa-Ha K, Kitano K.


Serum thrombopoietin (c-Mpl ligand) levels in patients with liver cirrhosis
BLOOD,86(10):3621-3621 1995
Author:Shimodaira, S; Ishida, F; Ichikawa, N; Tahara, T; Kato, T; Kodaira, H; Ito, T; Tanaka, E; Sodeyama, T; Kiyosawa, K; Kitano, K


DAF-deficient erythrocytes during the longterm clinical course of patients with paroxysmal nocturnal haemoglobinuria.
BLOOD,86(10):2535-2535 1995
Author:Mahbub, B; Kitano, K; Shimodaira, S; Ishida, F; Kiyosawa, K; Nishimura, J; Kitani, T


EOSINOPHILIA ASSOCIATED WITH PROLIFERATION OF CD3+4-8-ALPHA-BETA+ T-CELLS WITH CHROMOSOME-16 ANOMALIES
BLOOD,84(10):A136-A136 1994
Author:KITANO, K; MAHBUB, B; SHIMODAIRA, S; ICHIKAWA, N; KODAIRA, H; ISHIDA, F; OKUBO, Y; FURUTA, S


Eosinophilia in myelodysplastic syndrome with a (12;21)(q23;q22) translocation.
Cancer Genet Cytogenet,68(2):95-98 1993
Author:Kobayashi H, Kitano K, Shimodaira S, Ishida F, Saito H, Sonoyama M, Enokihara H, Furuta S.


DETECTION OF CLONAL PROLIFERATION OF LARGE GRANULAR LYMPHOCYTE PROLIFERATIVE DISORDERS
BLOOD,82(10):A579-A579 1993
Author:SHIMODAIRA, S; KITANO, K; MAHBUB, B; TERADA, N; KOBAYASHI, H; FURUTA, S


AGGRESSIVE GRANULAR LYMPHOCYTE LEUKEMIA OF NATURAL-KILLER-CELL TYPE IN AN ELDERLY PATIENT
INTERNAL MEDICINE,32(11):882-885 1993
Author:ICHIKAWA, N; KITANO, K; HIGUCHI, M; KOBAYASHI, H; TERADA, N; SHIMODAIRA, S;SONOYAMA, M; INOUE, M; KAWA, K; FURUTA, S


学会発表
IFN-α inducible dendritic cells matured with OK-432 exhibit professional antigen-presentation and anti-tumor activity
The International Cytokine & Interferon Society , 5th Annual Meeting 2017(Oct. 29)
Author:Koya T, Shimodaira S


Dendritic cell-based cancer immunotherapy
the 20th Annual Meeting of TAPAAI: New Era of Precision Medicien on Allergy and Immunology 2016(Sep. 25)
Author:Shimodaira S


金沢医科大学再生医療学と再生医療センター 再生医療・細胞治療拠点構築戦略
金沢医科大学雑誌 , 41(2):51 2016(Sep.)
Author:下平滋隆


平成27年度長野県献血推進協議会輸血療法部会の活動報告
血液事業 , 39(2):399 2016(Aug.)
Author:平林盛人, 渡邉満, 大田智, 五味高志, 小池敏幸, 齊藤敏, 佐藤博行, 佐伯成規, 斉藤邦昭, 下平滋隆


小規模医療機関対象に開催した輸血検査実技研修について
血液事業 , 39(2):469 2016(Aug.)
Author:大田智, 平林盛人, 渡邉満, 五味高志, 齊藤敏, 佐藤博行, 佐伯成規, 斉藤邦昭, 下平滋隆


BRS-AおよびM-solを用いて調製した置換血小板の比較検討
日本輸血細胞治療学会誌 , 62(3):507 2016(Jun.)
Author:小島聖美, 小嶋俊介, 竹村佳代, 赤羽由貴, 堀内香与, 下平滋隆


小児輸血医療における輸血副反応頻度の検討
日本輸血細胞治療学会誌 , 62(2):180 2016(Apr.)
Author:柳沢龍, 坂下一夫, 西島史恵, 下平滋隆


造血幹細胞移植・細胞治療における品質管理に関する遵守事項
日本輸血細胞治療学会誌 , 62(2):255 2016(Apr.)
Author:小嶋俊介, 下平滋隆


免疫チェックポイント分子と樹状細胞ワクチン療法の治療効能との関連性の検討
日本輸血細胞治療学会誌 , 62(2):293 2016(Apr.)
Author:湯沢美紀, 樋口由美子, 小屋照継, 山岡直子, 水野由美子, 石川伸介, 堀内香与, 吉江恵, 平林耕一, 小林孝至, 下平滋隆


樹状細胞療法による抗原特異的T細胞の誘導と疾患との関連性の検討
日本輸血細胞治療学会誌 , 62(2):293 2016(Apr.)
Author:水野由美子, 樋口由美子, 小屋照継, 湯沢美紀, 山岡直子, 石川伸介, 堀内香与, 吉江恵, 平林耕一, 小林孝至, 下平滋隆


幼児自己血採血時に生ずる心理的ストレスの評価および不安に対する意識を分散化させる関わりの検討
日本輸血細胞治療学会誌 , 62(2):334 2016(Apr.)
Author:塩崎暁子, 柳沢龍, 坂下一夫, 小野貴子, 立澤有香, 下平滋隆


小児輸血アレルギー反応に関連する患者背景の検討
日本輸血細胞治療学会誌 , 62(2):341 2016(Apr.)
Author:柳沢龍, 坂下一夫, 小野貴子, 立澤有香, 下平滋隆


3ヵ月児に発症した輸血関連急性肺障害の1例
日本輸血細胞治療学会誌 , 62(2):342 2016(Apr.)
Author:柳沢龍, 坂下一夫, 小野貴子, 立澤有香, 下平滋隆


当院におけるアルブミン製剤一元管理による適正使用の推進
日本輸血細胞治療学会誌 , 62(2):378 2016(Apr.)
Author:赤羽由貴, 小嶋俊介, 竹村佳代, 古川聖美, 堀内香与, 下平滋隆


学会認定・看護師制度から5年 横断的な輸血療法として 輸血に関わる地域包括ケアに向けた看護師の役割と活動
日本輸血細胞治療学会誌 , 61(5):巻末27 2015(Oct.)
Author:堀内香与, 小嶋俊介, 竹村佳代, 赤羽由貴, 小島聖美, 下平滋隆


長野県内における医療機関の危機管理体制の実態調査について
血液事業 , 38(2):409 2015(Aug.)
Author:平林盛人, 渡邉満, 大田智, 五味高志, 小池敏幸, 齊藤敏, 佐藤博行, 山崎光隆, 中村一彦, 小嶋俊介, 下平滋隆


輸血医療における看護師の役割 適正な輸血療法に向けた学会認定・臨床輸血看護師の役割
日本輸血細胞治療学会誌 , 61(2):216 2015(Apr.)
Author:堀内香与, 小嶋俊介, 竹村佳代, 赤羽由貴, 石川伸介, 下平滋隆


新規がん免疫細胞製剤の確立に向けた検討
日本輸血細胞治療学会誌 , 61(2):293 2015(Apr.)
Author:湯沢美紀, 樋口由美子, 小屋照継, 水野由美子, 山岡直子, 曾根田美樹, 堀内香与, 平林耕一, 小林孝至, 下平滋隆


樹状細胞ワクチン療法後の免疫モニタリングにおいて、高頻度に抗原特異的細胞傷害性T細胞が検出された膵癌の症例
日本輸血細胞治療学会誌 , 61(2):294 2015(Apr.)
Author:樋口由美子, 小屋照継, 湯沢美紀, 山岡直子, 水野由美子, 吉澤清司, 高橋香織, 曽根田美紀, 堀内香与, 平林耕一, 齋藤章治, 小林孝至, 下平滋隆


小児輸血医療における輸血副反応頻度の検討
日本輸血細胞治療学会誌 , 61(2):348 2015(Apr.)
Author:柳沢龍, 坂下一夫, 西島史恵, 下平滋隆


Cancer treatment with dendritic cells for patients visited from Kuwait.
The Forum of the Japan-UAE Joint Meeting for Cooperative promotion of Life Science-2013 in Tokyo 2013(Apr. 13)
Author:ShimodairaS


Harvesting the seeds of translational research: A clinical trial of dendritic cell–based vaccination.
12th International Symposium on dendritic cells. 2012(Oct. 09)
Author:Shimodaira S


WT1- and MUC1-pulsed DC vaccination against advanced cancers: Today and tomorrow.
1st ISCT Asia-Pacific Regional Meeting in Miyazaki 2010(Oct. 19)
Author:Shimodaira S


MISC
小児同種骨髄移植後possible TRALI
日本輸血細胞治療学会誌,62(3):439-440 2016(Jun.)
Author:柳沢龍, 村田マサ子, 坂下一夫, 下平滋隆, 石井栄三郎


WT1ペプチドパルス樹状細胞療法後に検出されたWT1特異的細胞傷害性T細胞
日本輸血細胞治療学会誌,61(3):401-402 2015(Jun.)
Author:樋口由美子, 小屋照継, 湯沢美紀, 山岡直子, 水野由美子, 吉澤清司, 高橋香織, 曽根田美樹, 堀内香与, 平林耕一, 齋藤章治, 小林孝至, 下平滋隆

特許等知的財産
登録済特許
分離装置
IFNを用いた非接着培養による樹状細胞の調製方法
G-CSFを用いた樹状細胞の調製方法
共同研究等希望テーマ
樹状細胞療法 , がん免疫療法
研究費
科学研究費補助金(研究代表者)
2012 - 2014 , 形質細胞様キラー樹状細胞の製造技術に関する研究 , 基盤研究(C)
研究諸活動
学術専門雑誌等編集
2012- , 日本輸血・細胞治療学会