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齋藤直人  サイトウ ナオト

教員組織信州大学医学部保健学科応用理学療法学電話番号
教育組織信州大学先鋭領域融合研究群バイオメディカル研究所FAX番号
職名教授・所長メールアドレスsaitoko@shinshu-u.ac.jp
住所〒390-8621 長野県松本市旭3-1-1ホームページURLhttp://www.shinshu-u.ac.jp/institution/ibs/

更新日:2019/05/29

プロフィール

兼担研究科・学部
信州大学大学院博士課程総合医理工学研究科生命医工学専攻
信州大学大学院修士課程総合理工学研究科生命医工学専攻
COE・クラスタ・
研究グループ
生体適合システム学
研究分野
整形外科学
リハビリテーション科学・福祉工学
生体医工学・生体材料学
ナノバイオサイエンス
医化学一般
所属学会
所属学会
American Chemical Society
日本整形外科学会
日本リハビリテーション医学会
日本リウマチ学会
日本バイオマテリアル学会
日本生理学会
日本分子生物学会
レギュラトリーサイエンス学会
炭素材料学会
日本骨代謝学会
日本人工関節学会
日本股関節学会
JOSKAS

所属学会役職担当
日本整形外科学会 , 専門医・代議員
日本リハビリテーション医学会 , 専門医・指導責任者
日本リウマチ学会 , 専門医
日本生体医工学会 , 評議員
学歴
出身学校・専攻等(大学院を除く)
1988 , 信州大学 , 医学部

免許・資格等
199309 , 麻酔科標榜医
19880524 , 医師免許
受賞学術賞
2012 , 信州大学医学科顕彰優秀論文賞
2010 , 信州大学医学科顕彰優秀論文賞
2002 , 日本整形外科学会 学会奨励賞
2002 , 信州大学医学部松医会賞
2001 , 整形災害外科学研究助成財団 アルケア奨励賞
1999 , 信州大学整形外科同門会賞
研究職歴等
研究職歴
2018- , 信州大学大学院博士課程総合医理工学研究科生命医工学専攻 専攻長
2016- , 信州大学大学院修士課程総合理工学研究科生命医工学専攻
2014- , 信州大学先鋭領域融合研究群バイオメディカル研究所 所長
2004- , 信州大学医学部保健学科応用理学療法学 教授
2003- , 信州大学 学校医
2009-2017 , 信州大学大学院医学系研究科博士後期過程医療生命科学 教授
2007-2015 , 信州大学大学院医学系研究科博士前期過程機能障害学 教授
2004-2007 , 信州大学医療技術短期大学部理学療法学科 教授
2001-2003 , 信州大学医学部附属病院整形外科 講師
1999-2001 , 信州大学医学部整形外科学講座 講師
1996-1999 , 信州大学医学部整形外科学講座 助手
1995-1996 , 信州大学医学部附属病院整形外科 医員
1989-1995 , 信州大学医学部 研究生 (整形外科学講座)
1988-1989 , 信州大学医学部附属病院整形外科 医員(研修医)

研究職歴以外の職歴
1990-1995 , 関連病院整形外科 医師
1990-1990 , 長野赤十字病院麻酔科 医師
1989-1990 , 関連病院整形外科 医師

研究活動業績

研究業績(著書・
発表論文等)
著書
Thin carbon fiber web that functions as a scaffold for tissue regeneration
Nova Science Publishers, Inc., New York , Advances in Medicine and Biology , 11:301-310 2011
Author:Saito N, Aoki K, Usui Y, Shimizu M, Hara K, Narita N, Ogihara N, Nakamura K, Ishigaki N, Kato H, Haniu H, Kim C, Taruta S, Kim YA, Endo M


Application of carbon nanotubes on scaffolds for bone tissue regeneration
Nova Science Publishers, Inc., New York , Bone regeneration: growth factors, augmentation procedures and tissue engineering applications , :pp 275-284 2010
Author:Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Haniu H, Taruta S, Endo M


New technology for bone tissue regeneration using cytokines and their drug delivery systems. In: Mashkevich BO (ed), Drug delivery research advances.
Nova Science Publishers, Inc., New York , :pp 227-241 2007
Author:.Saito N, Murakami N, Takaoka K.


New synthetic biodegradable polymers for bone morphogenetic protein delivery systems. Yaszemski MJ, Trantolo DJ, Lewandrowski KU, Hasirci V, Altobelli DE, Wise DL, eds: Tissue engineering and novel delivery systems.
Marcel Dekker inc, New York , :pp 475-482 2004
Author:Saito N, Horiuchi H, Murakami N, Takahashi J, Okada T, Nozaki K, Takaoka


New synthetic degradable polymers as carrier materials for BMP. In Wise DL(ed), Biomaterials engineering and devices: human applications, vol 1.
The Humana Press, New Jersey , :pp 239-249 2000
Author:Takaoka K, Miyamoto S, Saito N, Okada T.


Bone-inducing implants: new synthetic absorbable poly-D,L-lactic acid-polyethylene glycol block copolymers as BMP-carriers. In Ikada Y, Okano T(eds), Tissue engineering for therapeutic use, vol 3.
Elsevier Science B.V., Amsterdam , :pp 141-151 1999
Author:Takaoka K, Saito N, Miyamoto S, Yoshikawa H, Okada T.


論文
Different aggregation and shape characteristics of carbon materials affect biological responses in RAW264 cells
Int J Nanomed 2018
Author:Kuroda C, Ueda K, Haniu H, Ishida H, Okano S, Takizawa T, Sobajima A, Kamanaka H, Yoshida K, Okamoto M, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N


Lateralization of the tibial tubercle in recurrent patellar dislocation: verification using multiple evaluative methods for the tibial tubercle
J Bone Joint Surg Am,100:e58 2018
Author:Tensho K, Shimodaira H, Akaoka Y, Koyama S, Hatanaka D, Ikegami S, Kato H, Saito N


The acetabular fossa may not be located at the true center of the acetabulum: a detailed analysis using preoperative CT images
J Bone Joint Surg Am,100:e27 2018
Author:Shimodaira H, Tensho K, Akaoka Y, Koyama S, Maruyama M, Kato H, Saito N


Titanium fiber plates for bone tissue repair
Adv Mater,30:1703608 2017
Author:Takizawa T, Nakayama N, Haniu H, Aoki K, Okamoto M, Nomura H, Tanaka M, Sobajima A, Yoshida K, Kamanaka T, Ajima K, Oishi A, Kuroda C, Ishida H, Okano S, Kobayashi S, Kato H, Saito N


Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model
Sci Rep-UK,7:8630 2017
Author:Ogasawara T, Okano S, Ichimura H, Kadota S, Tanaka Y, Minami I, Uesugi M, Wada Y, Saito N, Okada K, Kuwahara K, Shiba Y


In vitro and in vivo evaluation of a three-dimensional porous multi-walled carbon nanotube scaffold for bone regeneration
Nanomaterials-Basel,l7:46 2017
Author:Tanaka M, Sato Y, Zhang M, Haniu H, Okamoto M, Aoki K, Takizawa T, Yoshida K, Sobajima A, Kamanaka T, Kato H, Saito N


A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler
PLoS One,12:e0172601 2017
Author:Tanaka M, Sato Y, Haniu H, Nomura H, Kobayashi S, Takanashi S, Okamoto M, Takizawa T, Aoki K, Usui Y, Oishi A, Kato H, Saito N


Physico-chemical, in vitro, and in vivo evaluation of a 3d unidirectional porous hydroxyapatite scaffold for bone regeneration
Materials,10:33 2017
Author:Tanaka M, Haniu H, Kamanaka T, Takizawa T, Sobajima A, Yoshida K, Aoki K, Okamoto M, Kato H, Saito N


The dispersion state of tangled multi-walled carbon nanotubes affects their cytotoxicity.
Nanomaterials-Basel.,6:219 2016
Author:Kuroda C, Haniu H, Ajima K, Tanaka M, Sobajima A, Ishida H, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N.


Remnant-preserving tibial tunnel positioning using anatomical landmarks in double-bundle anterior cruciate ligament reconstruction.
Arthroscopy,32(9):1822-1830 2016
Author:Shimodaira H, Tensho K, Akaoka Y, Takanashi S, Kato H, Saito N.


Differentiation of chemical reaction activity of various carbon nanotubes using redox potential: classification by physical and chemical structures
CARBON,95:302-308 2015(Dec.)
Author:Tsuruoka S, Matsumoto H, Castranova V, Porter DW, Yanagisawa T, Saito N, Kobayashi S, Endo M


Radical scavenging reaction kinetics with multi-walled carbon nanotubes
CARBON,83:232-239 2015(Mar.)
Author:Tsuruoka S, Matsumoto H, Koyama K, Akiba E, Yanagisawa T, Cassee FR, Saito N, Usui Y, Kobayashi S, Porter DW, Castranova V, Endo M


Influence of pmsa-based polymer on the settling velocity of cnt in aqueous media.
Mater Trans,56(12):2006-2009 2015
Author:Nishimura N, Takeda S, Teranishi T, Hayashi H, Saito N, Kishimoto A.


What components comprise the measurement of the tibial tuberosity-trochlear groove distance in a patellar dislocation population?
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME,97(17):1441-1448 2015
Author:Tensho K, Akaoka Y, Shimodaira H, Takanashi S, Ikegami S, Kato H, Saito N


Specific biological responses of the synovial membrane to carbon nanotubes
SCIENTIFIC REPORTS,5:14314 2015
Author:Nomura H, Takanashi S, Tanaka M, Haniu H, Aoki K, Okamoto M, Kobayashi S, Takizawa T, Usui Y, Oishi A, Kato H, Saito N


An advanced in-situ imaging method using heavy metal doped hollow tubes to evaluate the biokinetics of carbon nanotubes in vivo
NPG ASIA MATERIALS,7:e203 2015
Author:Kobayashi S, Tsuruoka S, Usui Y, Haniu H, Aoki K, Takanashi S, Okamoto M, Nomura H, Tanaka M, Aiso S, Saito M, Kato H, Saito N


Endocytosis of multiwalled carbon nanotubes in bronchial epithelial and mesothelial cells
BIOMED RESEARCH INTERNATIONAL,2015:793186 2015
Author:Maruyama K, Haniu H, Saito N, Matsuda Y, Tsukahara T, Kobayashi S, Tanaka M, Aoki K, Takanashi S, Okamoto M, Kato H


Bony Landmarks of the Anterior Cruciate Ligament Tibial Footprint A Detailed Analysis Comparing 3-Dimensional Computed Tomography Images to Visual and Histological Evaluations
AMERICAN JOURNAL OF SPORTS MEDICINE,42(6):1433-1440 2014(Jun.)
Author:Tensho, K; Shimodaira, H; Aoki, T; Narita, N; Kato, H; Kakegawa, A; Fukushima, N; Moriizumi, T; Fujii, M; Fujinaga, Y; Saito, N


Safe Clinical Use of Carbon Nanotubes as Innovative Biomaterials
CHEMICAL REVIEWS,114(11):6040-6079 2014(Jun.)
Author:Saito, N; Haniu, H; Usui, Y; Aoki, K; Hara, K; Takanashi, S; Shimizu, M; Narita, N; Okamoto, M; Kobayashi, S; Nomura, H; Kato, H; Nishimura, N; Taruta, S; Endo, M


Influence of CNF content on microstructure and fracture toughness of CNF/alumina composites
JOURNAL OF THE CERAMIC SOCIETY OF JAPAN,122(1424):292-299 2014(Apr.)
Author:Ueda, N; Yamakami, T; Yamaguchi, T; Usui, Y; Aoki, K; Endo, M; Saito, N; Taruta, S


Noncanonical Wnt5a enhances Wnt/beta-catenin signaling during osteoblastogenesis
SCIENTIFIC REPORTS,4:4493 2014(Mar.)
Author:Okamoto, M; Udagawa, N; Uehara, S; Maeda, K; Yamashita, T; Nakamichi, Y; Kato, H; Saito, N; Minami, Y; Takahashi, N; Kobayashi, Y


Snapping pes syndrome after total knee arthroplasty
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY,22(1):192-194 2014(Jan.)
Author:Tensho K, Aoki T, Morioka S, Narita N, Kato H, Saito N


Early post-operative intra-tunnel migration of the EndoButton after anatomical double-bundle anterior cruciate ligament reconstruction
JBJS CASE CONNECTOR,4(4):e88 2014
Author:Akaoka Y, Tensho K, Shimodaira H, Aoki T, Takanashi S, Kato H, Saito N


Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells
INTERNATIONAL JOURNAL OF NANOMEDICINE,9:1979-1990 2014
Author:Haniu, H; Saito, N; Matsuda, Y; Tsukahara, T; Usui, Y; Maruyama, K; Takanashi, S; Aoki, K; Kobayashi, S; Nomura, H; Tanaka, M; Okamoto, M; Kato, H


Effect of aspect ratio on the internal structure of titanium fiber formed by the compression shearing method at room temperature
JOURNAL OF THE JAPANESE SOCIETY FOR EXPERIMENTAL MECHANICS,13(Special Issue):s126-s130 2013
Author:Nakayama N, Izawa N, Horita M, Saito N, Miki H, Takeishi H


Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response
TOXICOLOGY IN VITRO,27(6):1679-1685 2013
Author:Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Tsukahara, Tamotsu; Maruyama, Kayo; Usui, Yuki; Aoki, Kaoru; Takanashi, Seiji; Kobayashi, Shinsuke; Nomura, Hiroki; Okamoto, Masanori; Shimizu, Masayuki; Kato, Hiroyuki


Effect of shearing strain on mechanical properties of titanium thin plate by compression shearing method at room temperature.
STEEL RESEARCH INTERNATIONAL,Special Edition Metal Forming:803-806 2012
Author:Horita M, Nakayama N, Saito N, Miki H, Miyazaki T, Takeishi H.


Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts
ADVANCED MATERIALS,24:2176-2185 2012
Author:Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N


Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice
SCIENTIFIC REPORTS,2:498 2012
Author:Takanashi S, Hara K, Aoki K, Usui Y, Shimizu M, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Okamoto M, Kobayashi S, Kato H, Sano K, Nishimura N, Tsutsumi H, Machida K Saito N


Microstructure development and fracture toughness of acid-treated carbon nanofibers/alumina composites
JOURNAL OF THE CERAMIC SOCIETY OF JAPAN,120(12):560-568 2012
Author:Ueda N, Yamakami T, Yamaguchi T, Kitajima K, Usui Y, Aoki K, Endo M, Saito N, Taruta S


Basic Potentialof Carbon Nanotubes in Tissue Engineering Applications
JOURNAL OF NANOMATERIALS,2012:34374 2012
Author:Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Tsukahara, Tamotsu; Usui, Yuki; Narita, Nobuyo; Hara, Kazuo; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Takanashi, Seiji; Okamoto, Masanori; Kobayashi, Shinsuke; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki


Carbon nanotubes innovate on medical technology
MEDICINAL CHEMISTRY,2:1-6 2012
Author:Usui Y, Haniu H, Tsuruoka S, Saito N


Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes
NANOMEDICINE,7:981-993 2012
Author:Ogihara N, Usui Y, Aoki K, Shimizu M, Narita N, Hara K, Nakamura K, Ishigaki N, Takanashi S, Okamoto M, Kato H, Haniu H, Ogiwara N, Nakayama N, Taruta S, Saito N.


Manufacturing strategy for multi-walled carbon nanotubes as a biocompatible and innovative material
JOURNAL OF NANOTECHNOLOGY,937819:1-6 2012
Author:Haniu H, Saito N, Matsuda Y, Usui Y, Aoki K, ShimizuM, Ogihara N, Hara K, Takanashi S, Okamoto M, Nakamura K, Ishigaki N, Tsukahara T, Kato H.


Application of carbon fibers to biomaterials: new era of nano-level control of carbon fibers after 30-years of development
CHEMICAL SOCIETY REVIEWS,40(7):3824-3834 2011
Author:Saito N, Aoki K, Usui Y, Shimizu M,Hara K, Narita N, Ogihara N,Nakamura K, Ishigaki N, Kato H, Haniu H, Taruta S, Kim YA, Endo M.


Toxicoproteomic evaluation of carbon nanomaterials in vitro
JOURNAL OF PROTEOMICS,74(12):2703-2712 2011
Author:Haniu H, Matsuda Y, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Okamoto M,Takanashi S, Ishigaki N, Nakamura K, Kato H, Saito N.


Deposition of apatite on carbon nanofibers in simulated body fluid
JOURNAL OF NANOMATERIALS,935320:1-8 2011
Author:Taruta S, Kidokoro K, Yamakami T, Yamaguchi T, Kitajima K, Endo M, Saito N.


Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses
INTERNATIONAL JOURNAL OF NANOMEDICINE,6(1):3295-3307 2011
Author:Haniu H, Saito N, Matsuda Y, Kim YA, Park KC, Tsukahara T, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H.


Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines
INTERNATIONAL JOURNAL OF NANOMEDICINE,6:3487-3497 2011
Author:Haniu H, Saito N, Matsuda Y, Kim YA, Park KC, Tsukahara T, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H.


DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes
INTERNATIONAL JOURNAL OF NANOMEDICINE,6(1):2689-2695 2011
Author:Haniu H, Tsukahara T, Matsuda Y, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H, Saito N.


Evaluation of CNTtoxicity in comparison to tattoo ink nanoparticles for use as a biomaterial
MATERIALS TODAY,14:434-440 2011
Author:Hara K, Aoki K, Usui Y, Shimizu M, Narita N, Ogihara N, Nakamura K, Ishigaki N, Sano K, Haniu H, Kato H, Nishimura N, Kim YA, Taruta S, Saito N.


Analysis of pelvic movement in the elderly duringwalking using a posture monitoring system equipped with a triaxial accelerometer and a gyroscope
JOURNAL OF BIOMECHANICS,44:1788-1792 2011
Author:Ishigaki N, Kimura T, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogihara N, Nakamura K, Kato H, Ohira M, Yokokawa Y, Miyoshi K, Murakami N, Okada S, Nakamura T, Saito N.


Anatomic double-bundle anterior cruciate ligament reconstruction, using CT-based navigation and fiducial markers
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY,19:378–383 2011
Author:Tensho K, Kodaira H, Yasuda G, Yoshimura Y, Narita N, Morioka S, Kato H, Saito N


Fabrication and mechanical properties of high-dispersion-treated carbon nanofiber/alumina composites
JOURNAL OF THE CERAMIC SOCIETY OF JAPAN,118(9):847-854 2010
Author:Ueda N, Yamakami T, Yamaguchi T, Kitajima K, Usui Y, Aoki K, Nakanishi T, Miyaji F, Endo M, Saito N


Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function
NANO LETTERS,9(4):1406-1413 2009
Author:Narita N, Kobayashi Y, Nakamura H, Maeda K, Ishihara A, Mizoguchi T, Usui Y, Aoki K, Shimizu M, Kato H, Ozawa H, Udagawa N, Endo M, Takahashi N, Saito N


Carbon nanotubes: Biomaterial applications
CHEMICAL SOCIETY REVIEWS,38(7):1897-1903 2009
Author:Saito, N; Usui, Y; Aoki, K; Narita, N; Shimizu, M; Hara, K; Ogiwara, N; Nakamura, K; Ishigaki, N; Kato, H; Taruta, S; Endo, M


A Thin Carbon Fiber Web as a Scaffold for Bone Tissue Regeneration
SMALL,5(13):1540-1546 2009
Author:Aoki, K; Usui, Y; Narita, N; Ogiwara, N; Ishigaki, N; Nakamura, K; Kato, H; Sano, K; Ogiwara, N; Kametani, K; Kim, C; Taruta, S; Kim, YA; Endo, M; Saito, N


Carbon nanotubes for biomaterials in contact with bone
CURRENT MEDICINAL CHEMISTRY,15(5):523-527 2008
Author:Saito, N; Usui, Y;Aoki, K; Narita, N; Shimizu, M; Ogiwara, N; Nakamura,K; Ishigaki, N; Kato, H; Taruta, S; Endo, M


Carbon nanotubes with high bone-tissue compatibility and bone-formation acceleration effect
SMALL,4(2):240-246 2008
Author:Usui, Y; Aoki, K; Narita, N; Murakami, N; Nakamura, I; Nakamura, K; Ishigaki, N; Yamazaki, H; Horiuchi, H; Kato, H; Taruta, S; Kim, YA; Endo, M; Saito, N


Brothers with genu recurvatum
KNEE,14(6):500-501 2007
Author:Saito, N; Tensyo, K; Horiuchi, H; Aoki, K; Kobayashi, S; Kato, H; Kosh, T


Coordinate expression of BMP-2, BMP receptors and Noggin in normal mouse spine
JOURNAL OF CLINICAL NEUROSCIENCE,13(2):250-256 2006
Author:Nakamura Y, Nakaya H, Saito N, Wakitani S.


Potentiation of the activity of bone morphogenetic protein-2 in bone regeneration by a PLA-PEG/hydroxyapatite composite
BIOMATERIALS,26(1):73-79 2005
Author:Kaito, T; Myoui, A; Takaoka, K; Saito, N; Nishikawa, M; Tamai, N; Ohgushi, H; Yoshikawa, H


Use of bone morphogenetic protein 2 and diffusion chambers to engineer cartilage tissue for the repair of defects in articular cartilage
ARTHRITIS AND RHEUMATISM,52(1):155-163 2005
Author:Nawata, M; Wakitani, S;Nakaya, H; Tanigami, A; Seki, T; Nakamura, Y; Saito, N; Sano, K; Hidaka, E; Takaoka, K


Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins
ADVANCED DRUG DELIVERY REVIEWS,57(7):1037-1048 2005
Author:Saito N, Murakami N, Takahashi J, Horiuchi H, Ota H, Kato H, Okada T, Nozaki K, Takaoka K.


Expression profiles of BMP-related molecules induced by BMP-2 or-4 in muscle-derived primary culture cells
JOURNAL OF BONE AND MINERAL METABOLISM,23(6):426-434 2005
Author:Nakamura Y, Wakitani S, Saito N, Takaoka K.


The effects of heat on the biological activity of recombinant human bone morphogenetic protein-2
JOURNAL OF BONE AND MINERAL METABOLISM,23(6):420-425 2005
Author:Ohta H,Wakitani S, Tensho K, Horiuchi H, Wakabayashi S, Saito N, Nakamura Y, Nozaki K, Imai Y, Takaoka K.


Heterotopic ossification in the knee following encephalitis: a case report with a 10-year follow-up
KNEE,11(1):63-65 2004
Author:Saito, N; Horiuchi, H; Takahashi, H


Continuous local cooling for pain relief following total hip arthroplasty
JOURNAL OF ARTHROPLASTY,19(3):334-337 2004
Author:Saito, N; Horiuchi, H; Kobayashi, S; Nawata, M; Takaoka, K


Enhancement of recombinant human bone morphogenetic protein-2 (rhBMP-2)-induced new bone formation by concurrent treatment with parathyroid hormone and a phosphodiesterase inhibitor, pentoxifylline
JOURNAL OF BONE AND MINERAL METABOLISM,22(4):329-334 2004
Author:Horiuchi, H; Saito, N; Kinoshita, T; Wakabayashi, S; Tsutsumimoto, T; Otsuru, S; Takaoka, K


Osteonecrosis of the femoral head in Japanese adults after liver transplantation: a preliminary report
JOURNAL OF ORTHOPAEDIC SCIENCE,9(2):119-121 2004
Author:Horiuchi, H; Hashikura, Y; Hisa, K; Saito, N; Ikegami, T; Nakazawa, Y; Karakida, O; Kobayashi, S; Nawata, M; Kawasaki, S; Takaoka, K


Locking of the knee couasedby localized pigmented villonodular synovitis: a case report
MODERN RHEUMATOLOGY,14:184-186 2004
Author:Horiuchi H, Nawata M, Kamijo T, Saito N, Wakitani S, Kobayashi S, Shimizu T, Koto H.


Total hip arthroplasty with bulk femoral head autograft for acetabular reconstruction in DDH: surgical technique
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME,86 Supple 1:11-17 2004
Author:Kobayashi S, Saito N, Nawata M, Horiuchi H, Iorio R, Takaoka K.


Trabecular minimodeling in human iliac bone
BONE,32(2):163-169 2003
Author:Kobayashi, S; Takahashi, HE; Ito, A; Saito, N; Nawata, M; Horiuchi, H; Ohta, H; Ito, A; Iorio, R; Yamamoto, N; Takaoka, K


Total hip arthroplasty with bulk femoral head autograft for acetabular reconstruction in developmental dysplasia of the hip
JOURNAL OF BONE AND JOINT SURGERY-AMERICANVOLUME,85A(4):615-621 2003
Author:Kobayashi, S; Saito, N; Nawata, M; Horiuchi, H; Iorio, R; Takaoka, K


Anterior thoracic spinal fusion in dogs by injection of recombinant human bone morphogenetic protein-2 and a synthetic polymer
JOURNAL OF SPINAL DISORDERS&TECHNIQUES,16(2):137-143 2003
Author:Takahashi, J; Saito, N; Ebara, S; Kinoshita, T; Itoh, H; Okada, T; Nozaki, K; Takaoka, K


New synthetic biodegradable polymers as BMP carriers for bone tissue engineering
BIOMATERIALS,24(13):2287-2293 2003
Author:Saito, N; Takaoka, K


Repair of a proximal femoral bone defect in dogs using a porous surfaced prosthesis in combination with recombinant BMP-2 and a synthetic polymer carrier
BIOMATERIALS,24(13):2153-2159 2003
Author:Murakami, N; Saito, N; Takahashi, J; Ota, H; Horiuchi, H; Nawata, M; Okada, T; Nozaki, K; Takaoka, K


Local bone formation by injection of recombinant human bone morphogenetic protein-2 contained in polymer carriers
BONE,32(4):381-386 2003
Author:Saito, N; Okada, T; Horiuchi, H; Ota, H; Takahashi, J; Murakami, N; Nawata, M; Kojima, S; Nozaki, K; Takaoka, K


Sequential changes in periprosthetic bone mineral density following total hip arthroplasty: a 3-year follow-up
JOURNAL OF BONE AND MINERAL METABOLISM,21(4):229-233 2003
Author:Ohta, H; Kobayashi, S; Saito, N; Nawata, M; Horiuchi, H; Takaoka, K


Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption
ENDOCRINOLOGY,144(12):5441-5449 2003
Author:Nakamura, M; Udagawa, N; Matsuura, S; Mogi, M; Nakamura, H; Horiuchi, H; Saito, N; Hiraoka, BY; Kobayashi, Y; Takaoka, K; Ozawa, H; Miyazawa, H; Takahashi, N


Extraskeletal chondroma of the hand accompanied by proliferating chondroblast-like cells with an eleven-year follow-up
AMERICAN JOURNAL OF CASE REPORTS,4:66-68 2003
Author:Saito N, Horiuchi H, Toriumi H, Miyasaka T.


Effect of phosphodiesterase inhibitor-4, Rolipram, on new bone formations by recombinant human bone morphogenetic protein-2
BONE,30(4):589-593 2002
Author:Horiuchi, H; Saito, N; Kinoshita, T; Wakabayashi, S; Yotsumoto, N; Takaoka, K


Avascular necrosis of the femoral head in a patient with Fabry's disease - Identification of ceramide trihexoside in the bone by delayed-extraction matrix-assisted laser desorption ionization-time-of-flight mass spectrometry
ARTHRITIS AND RHEUMATISM,46(7):1922-1925 2002
Author:Horiuchi, H; Saito, N; Kobayashi, S; Ota, H; Taketomi, T; Takaoka, K


Repair of segmental defects in rabbit humeri with titanium fiber mesh cylinders containing recombinant human bone morphogenetic protein-2 (rhBMP-2) and a synthetic polymer
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,62(2):169-174 2002
Author:Murakami, N; Saito, N; Horiuchi, H; Okada, T; Nozaki, K; Takaoka, K


Three-dimentional computed tomography evaluation of bony birth canal morphologic deformity (small pelvic cavity) after dome pelvic osteotomy for developmental dysplasia of the hip
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY,187:1591-1595 2002
Author:Kojima S, Kobayashi S, Saito N, Nawata M, Horiuchi H, Takaoka K.


Enhancement of bone morphogenetic protein-2-induced new bone formation in mice by the phosphodiesterase inhibitor pentoxifylline
BONE,28(3):290-294 2001
Author:Horiuchi, H; Saito, N; Kinoshita, T; Wakabayashi, S; Tsutsumimoto, T; Takaoka, K


Progressive scoliosis in cri-du-chat syndrome over a 20-year follow-up period - A case report
SPINE,26(7):835-837 2001
Author:Saito, N; Ebara, S; Fukushima, Y; Wakui, K; Takaoka, K


A biodegradable polymer as a cytokine delivery system for inducing bone formation
NATURE BIOTECHNOLOGY,19(4):332-335 2001
Author:Saito, N; Okada,T; Horiuchi, H; Murakami, N; Takahashi, J; Nawata, M; Ota, H; Nozaki, K; Takaoka, K


Biodegradable poly-D,L-lacticacid-polyethylene glycol block copolymers as a BMP delivery system for inducing bone
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME,83A:S92-S98 2001
Author:Saito, N; Okada, T; Horiuchi,H; Murakami, N; Takakashi, J; Nawata, M; Ota, H; Miyamoto, S; Nozaki, K; Takaoka, K


Morphological characteristics of the bony birth canal in patients with developmental dysplasia of the hip (DDH): investigation by three-dimensional CT
JOURNAL OF ORTHOPAEDIC SCIENCE,6:217-222 2001
Author:Kojima S, Kobayashi S, Saito N, Nawata M, Horiuchi H, Takaoka K.


Poor bone quality or hip structure as risk factors affecting survival of total-hip arthroplasty
LANCET,355(9214):1499-1504 2000
Author:Kobayashi S, Saito N, Horiuchi H, Iorio R, Takaoka K.


New synthetic absorbable polymers as BMP carriers: Plastic properties of poly-D,L-lactic acid-polyethylene glycol block copolymers
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,47(1):104-110 1999
Author:Saito N, Okada T, Toba S, Miyamoto S, Takaoka K.


Natural history of scoliosis in spastic cerebral palsy
LANCET,351(9117):1687-1692 1998
Author:Saito N, Ebara S, Ohotsuka K, Kumeta H, Takaoka K.


Long-term bone remodeling around Charnley femoral prostheses: comparison of cementing techniques
ARCHIVES OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS,1:30-33 1997
Author:Kobayashi S, Takaoka K, Saito N, Hisa K.


Factors affecting aseptic failure of fixation after primary charnley totalhip arthroplasty - Multivariate survival analysis
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME,79A(11):1618-1627 1997
Author:Kobayashi S, Takaoka K, Saito N, Hisa K.


Radiographic factors predicting non-union of displaced intracapsular femoral neck fracture
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY,114:183-187 1995
Author:Saito N, Miyasaka T, Toriumi H.

研究費
科学研究費補助金(研究代表者)
2017 - 2020 , 癌転移骨環境を空間的・時間的に制御する生体活性付加カーボンの開発と安全性評価 , 基盤研究(A)
2015 - 2017 , 小骨固定・骨移植・骨再生・エンテーシス再建のためのチタンペーパーの開発 , 挑戦的萌芽研究
2012 - 2016 , CNTを応用した高機能生体材料創製のためのCNT・生体界面技術の構築と安全性 , 基盤研究(A)
2012 - 2014 , 骨組織再生のためのナノカーボンファイバーシートを用いた機能性足場材の開発 , 挑戦的萌芽研究
2012 - 2014 , カーボンナノチューブとPEEK材を複合する技術を活用した脊椎手術のための高機能インプラントの開発 , 厚生労働科学研究費補助金 医療機器開発推進研究事業
2006 - 2009 , 人工関節のための新規生体材料であるカーボンナノチューブ・セラミックス複合体の開発 , 基盤研究(A)
2005 - 2007 , 骨髄単核球細胞移植を用いた大腿骨頭壊死症に対する新しい治療技術の開発 , 萌芽研究
2002 - 2005 , 骨形成タンパク(BMP)による骨修復能力を付加した新しい人工関節の開発 , 基盤研究(B)
2000 - 2001 , 骨形成因子(BMP)による骨修復能力を付加した新しい人工関節の開発 , 基盤研究(C)
1998 - 1999 , 経皮的に生体内に注入できる骨形成因子のための新しい合成担体の開発と応用 , 基盤研究(C)

受託事業
2017 - 2022 , 生理学的データ統合システムの構築による生体埋込型・装着型デバイス開発基盤の創出(JST研究成果展開事業産学共創プラットフォーム共同研究推進プログラム)領域統括
2017 - 2022 , 革新的無機結晶材料技術の産業実装による信州型地域イノベーション・エコシステム(JST地域イノベーション・エコシステム形成プログラム)課題代表
2015 - 2017 , 世界初・日本発のカーボンナノチューブ複合ポリエチレンソケットを使用した人工関節の実用化研究(AMED 医療機器開発推進研究事業)研究代表
2012 - 2013 , 界面制御CNTコンポジット材料を用いた高機能人工関節の安全性の開発(経済産業省 課題解決型医療機器等開発事業)研究代表
2011 - 2015 , ナノ材料の安全・安心確保のための国際先導的安全性評価技術の開発(経済産業省 低炭素社会を実現する超軽量・高強度革新的融合材料プロジェクト)課題リーダー
2011 - 2011 , 界面制御CNTコンポジット材料を用いた高機能人工関節の開発(経済産業省 課題解決型医療機器の開発・改良に向けた病院・企業間の連携支援事業)研究代表
2011 - 2011 , 個人差に対応したカーボンナノチューブの安全性評価システムの開発(JST 研究成果最適展開支援プログラムA-STEP FSステージ探索タイプ)研究代表
2010 - 2013 , エキゾチック・ナノカーボンの創成と応用(JST 地域卓越研究者戦略的結集プログラム)課題リーダー
2007 - 2011 , ナノカーボンを利用したスマートデバイスの研究開発(文部科学省 地域イノベーション戦略支援プログラム)課題リーダー
2007 - 2009 , ナノバイオテクノロジーによる高機能人工関節摺動部材の研究開発 (NEDO  ナノテク・先端部材実用化研究開発)研究代表
2006 - 2007 , 人体姿勢モニタリング装置を用いた転倒予防プログラムの開発(地域産学官共同研究活性化財団版RSP事業 可能性試験)研究代表
2004 - 2004 , 関節穿刺時の疼痛緩和のための局所冷却装置の開発(地域産学官共同研究活性化財団版RSP事業 可能性試験)研究代表

その他公的資金
2004 - 2004 , 骨髄単核球細胞移植による血管再生を用いた骨組織修復技術の開発 (中冨健康科学振興財団 研究助成)
2002 - 2002 , 骨形成因子(BMP)による骨修復能力を付加した新しい人工関節の開発 (財団法人テルモ科学振興財団 一般研究助成)
2001 - 2001 , 高齢者の骨折を早期に骨癒合させるサイトカイン療法の開発(財団法人ノバルテイス科学振興財団 研究奨励金)
2000 - 2001 , 注射が可能な骨形成因子(BMP)のためのDrug Delivery Systemの開発と応用-低侵襲で骨形成を促進する新しい治療手技 (財団法人整形災害外科研究助成財団 研究助成)
2000 - 2000 , 骨形成因子(BMP)による骨修復能力を付加した新しい人工股関節の開発 (財団法人日本股関節研究振興財団 研究助成)
1999 - 1999 , 骨形成因子(BMP)による骨修復能力を付加した新しい人工関節の開発 (財団法人日本リウマチ財団 調査・研究助成)

教育活動実績

授業等
先鋭領域融合研究群最先端研究特講
特別招へい教授グローバル研究特講
社会医工学特論
イノベーションセミナー
運動器生体医工学
ナノ生体材料学
境界生命科学
臨床医学概論
医療倫理学・社会医工学
行政・企業インターンシップ研修
病院インターンシップ研修