著書 Self-Assembled Receptors for Protein Surface Recognition Elsevier, Oxford , Comprehensive Supramolecular Chemistry II , :351-369 2017 Author:Junko Ohkanda
論文 Fusicoccin: A chemical modulator for 14-3-3 proteins Chemistry Letters,50:57-67 2021 Author:Junko Ohkanda
Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors Chemical Communications,56:11203-11206 2020(Aug. 21) Author:Yusuke Hosoya, Wataru Nojo, Isao Kii, Takanori Suzuki, Miki Imanishi, Junko Ohkanda
A novel condensed heterocyclic quinone with a dibenzofuranobisthiadiazole skeleton Heterocycles,101:99-103 2020 Author:Kazuma Sugawara, Wataru Nojo, Yusuke Ishigaki, Junko Ohkanda, Takanori Suzuki
Copper-Free Huisgen Cycloaddition for the 14-3-3-Templated Synthesis of Fusicoccin-Peptide Conjugates CHEMISTRY-AN ASIAN JOURNAL,15:742-747 2020 Author:Masuda, Ryoma; Kawasaki, Yuuya; Igawa, Kazunobu; Manabe, Yoshiyuki; Fujii, Hiroshi; Kato, Nobuo; Tomooka, Katsuhiko; Ohkanda, Junko;
Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine BIOCONJUGATE CHEMISTRY,30(2):454-460 2019(Feb.) Author:Kawaguchi, Yoshimasa; Ise, Shoko; Azuma, Yusuke; Takeuchi, Toshihide; Kawano, Kenichi; Toan Khanh Le; Ohkanda, Junko; Futaki, Shiroh;
A Guanidyl-Based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-Raf CHEMISTRY-A EUROPEAN JOURNAL,25(59):13531-13536 2019 Author:Tsubamoto, Mai; Toan Khanh Le; Li, Minghua; Watanabe, Taku; Matsumi, Chiemi; Parvatkar, Prakash; Fujii, Hiroshi; Kato, Nobuo; Sun, Jiazhi; Ohkanda, Junko;
Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity CHEMISTRY-A EUROPEAN JOURNAL,24(60):16066-16071 2018 Author:Ohkanda, Junko; Kusumoto, Atsushi; Punzalan, Louvy; Masuda, Ryoma; Wang, Chenyu; Parvatkar, Prakash; Akase, Dai; Aida, Misako; Uesugi, Motonari; Higuchi, Yusuke; Kato, Nobuo;
A Strategy of Designing Mid-sized Synthetic Molecules that Recognize Interfaces of Protein protein Interactions JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN,75(7):735-745 2017(Jul.) Author:Ohkanda, Junko;
Wiberg Bond Index 低原子価有機アルミニウム Ras蛋白 有機スズ高配位化錯体 有機合成化学協会誌,75(7):772-772 2017 Author:河内 敦; 吾郷 友宏; 大神田 淳子; 芝田 育也;
Protein-guided self-assembly for controlling protein-protein interactions Journal of the Society of Japanese Women Scientists,17:1-7 2017 Author:Junko Ohkanda
Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,137(50):15624-15627 2015 Author:Parvatkar, Prakash; Kato, Nobuo; Uesugi, Motonari; Sato, Shin-ichi; Ohkanda, Junko;*
RNA-Directed Amino Acid Coupling as a Model Reaction for Primitive Coded Translation CHEMBIOCHEM,15(6):794-798 2014 Author:Harada, Kazuo*; Aoyama, Shoko; Matsugami, Akimasa; Kumar, Penmetcha K. R.; Katahira, Masato; Kato, Nobuo; Ohkanda, Junko;
Module Assembly for Designing Multivalent Mid-Sized Inhibitors of Protein-Protein Interactions CHEMICAL RECORD,13(6):561-575 2013(Dec.) Author:Ohkanda, Junko;*
Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers ACS CHEMICAL BIOLOGY,8(9):1869-1875 2013(Sep.) Author:Molzan, Manuela; Kasper, Stefan; Roeglin, Lars; Skwarczynska, Malgorzata; Sassa, Takeshi; Inoue, Takatsugu; Breitenbuecher, Frank; Ohkanda, Junko; Kato, Nobuo; Schuler, Martin; Ottmann, Christian;
Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein MOLECULAR BIOSYSTEMS,9(5):940-943 2013 Author:Maki, Toshio; Kawamura, Akie; Kato, Nobuo; Ohkanda, Junko;*
Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase CHEMICAL COMMUNICATIONS,49(49):5535-5537 2013 Author:Hayashi, Daisuke; Kato, Nobuo; Kuzuyama, Tomohisa; Sato, Yasuo; Ohkanda, Junko;*
A Semisynthetic Fusicoccane Stabilizes a Protein-Protein Interaction and Enhances the Expression of K+ Channels at the Cell Surface CHEMISTRY & BIOLOGY,20(4):583-593 2013 Author:Anders, Carolin; Higuchi, Yusuke; Koschinsky, Kristin; Bartel, Maria; Schumacher, Benjamin; Thiel, Philipp; Nitta, Hajime; Preisig-Mueller, Regina; Schlichthoerl, Guenter; Renigunta, Vijay; Ohkanda, Junko; Daut, Juergen; Kato, Nobuo; Ottmann, Christian;
Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for alpha-chymotrypsin and cytochrome c BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(6):2354-2358 2012 Author:Yamaguchi, Yoshinobu; Kato, Nobuo; Azuma, Hideki; Nagasaki, Takeshi; Ohkanda, Junko;*
Bivalent Inhibitors for Disrupting Protein Surface-Substrate Interactions and for Dual Inhibition of Protein Prenyltransferases JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,133(4):958-963 2011 Author:Machida, Shinnosuke; Kato, Nobuo; Harada, Kazuo; Ohkanda, Junko;*
Protein surface recognition by dendritic ruthenium(II) tris(bipyridine) complexes CHEMICAL COMMUNICATIONS,(45):6949-6951 2009 Author:Ohkanda, Junko; Satoh, Ritsuko; Kato, Nobuo;
Structurally Simple Inhibitors of Lanosterol 14 alpha-Demethylase Are Efficacious In a Rodent Model of Acute Chagas Disease JOURNAL OF MEDICINAL CHEMISTRY,52(12):3703-3715 2009 Author:Suryadevara, Praveen Kumar; Olepu, Srinivas; Lockman, Jeffrey W.; Ohkanda, Junko; Karimi, Mandana; Verlinde, Christophe L. M. J.; Kraus, James M.; Schoepe, Jan; Van Voorhis, Wesley C.; Hamilton, Andrew D.; Buckner, Frederick S.; Gelb, Michael H.;
Transannular Proton Transfer in the Cyclization of Geranylgeranyl Diphosphate to Fusicoccadiene, a Biosynthetic Intermediate of Fusicoccins ORGANIC LETTERS,11(14):3044-3047 2009 Author:Toyomasu, Tomonobu; Tsukahara, Mai; Kenmoku, Hiromichi; Anada, Masahide; Nitta, Hajime; Ohkanda, Junko; Mitsuhashi, Wataru; Sassa, Takeshi; Kato, Nobuo;
Design and functional evaluation of dual prenyltransferase inhibitors for simultaneous recognition of active site and exterior protein surface ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,238:- 2009 Author:Machida, Shinnosuke; Kato, Nobuo; Harada, Kazuo; Ohkanda, Junko;
Module assembly for protein-surface recognition: Geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces CHEMISTRY-A EUROPEAN JOURNAL,14(5):1392-1401 2008 Author:Machida, Shinnosuke; Usuba, Kakeru; Blaskovich, Michelle A.; Yano, Akiko; Harada, Kazuo; Sebti, Said M.; Kato, Nobuo; Ohkanda, Junko;
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter ONCOGENE,26(5):633-640 2007(Feb.) Author:Delarue, F. L.; Adnane, J.; Joshi, B.; Blaskovich, M. A.; Wang, D-A; Hawker, J.; Bizouarn, F.; Ohkanda, J.; Zhu, K.; Hamilton, A. D.; Chellappan, S.; Sebti, S. M.;
ORGN 129-Bivalent inhibitors of Type-I geranylgeranyltransferase for simultaneous recognition of interior and exterior protein surfaces ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,234:- 2007 Author:Ohkanda, Junko; Machida, Shinnosuke; Kato, Nobuo; Blaskovich, Michelle A.; Sebti, Saied M.; Harada, Kazuo;
A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,100(25):15149-15153 2003 Author:Buckner, F; Yokoyama, K; Lockman, J; Aikenhead, K; Ohkanda, J; Sadilek, M; Sebti, S; Van Voorhis, W; Hamilton, A; Gelb, MH;
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice CANCER RESEARCH,63(24):8922-8929 2003 Author:Sun, JZ; Ohkanda, J; Coppola, D; Yin, H; Kothare, M; Busciglio, B; Hamilton, AD; Sebti, SM;
The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status CELL DEATH AND DIFFERENTIATION,9(7):702-709 2002(Jul.) Author:Crespo, NC; Delarue, F; Ohkanda, J; Carrico, D; Hamilton, AD; Sebti, SM;
CAAX peptidomimetics: Their farnesyltransferase inhibition activity and antitumor effect SEIKAGAKU,74(1):46-50 2002(Jan.) Author:Ohkanda, J;
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold JOURNAL OF MEDICINAL CHEMISTRY,45(1):177-188 2002 Author:Ohkanda, J; Lockman, JW; Kothare, MA; Qian, YM; Blaskovich, MA; Sebti, SM; Hamilton, AD;
Prenyltransferase inhibitors as antitumor and antiparasitic agents: Rational design based on CAAX peptide and solution phase combinatorial approaches. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,224:U30-U30 2002 Author:Ohkanda, J; Lockman, JW; Carrico, D; Strickland, CL; Sebti, SM; Gelb, MH; Hamilton, AD;
Design, synthesis and evaluation of peptidomimetic farnesyltransferase inhibitor ester pro-drugs as potent antiparasitic agents. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,224:U28-U28 2002 Author:Carrico, D; Ohkanda, J; Gelb, MH; Blaskovich, MA; Sebti, SM; Hamilton, AD;
Toward Chagas disease chemotherapeutics: Development of simple compounds active against Trypanosoma cruzi. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,224:U17-U17 2002 Author:Lockman, JW; Ohkanda, J; Yokoyama, K; Eastman, RT; Buckner, FS; Gelb, MH; Hamilton, AD;
Synthesis of linear and cyclic hexapeptides with N epsilon-(1,2-dihydro-1-hydroxy-2-oxopyrimidin-4-yl)-L-lysyl-beta-alanyl as the repeating unit and properties of their iron(III) complexes HETEROCYCLES,58:371-381 2002 Author:Katoh, A; Inoue, Y; Nagashima, H; Hikita, Y; Ohkanda, J; Saito, R;
The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells JOURNAL OF BIOLOGICAL CHEMISTRY,276(19):16161-16167 2001 Author:Crespo, NC; Ohkanda, J; Yen, TJ; Hamilton, AD; Sebti, SM;
3-hydroxy-4(1H)-pyridinone-containing linear and cyclic hexapeptides and their iron(III) complexes - Synthesis, property, and the growth-promotion activity- HETEROCYCLES,55(11):2171-2187 2001 Author:Katoh, A; Hikita, Y; Harata, M; Ohkanda, J; Tsubomura, T; Higuchi, A; Saito, R; Harada, K;
Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone CARCINOGENESIS,21(1):113-116 2000(Jan.) Author:Lantry, LE; Zhang, ZQ; Yao, RS; Crist, KA; Wang, Y; Ohkanda, J; Hamilton, AD; Sebti, SM; Lubet, RA; You, M;
Synthesis of quinoxaline derivatives bearing the styryl and phenylethynyl groups and application to a fluorescence derivatization reagent HETEROCYCLES,52(2):911-920 2000 Author:Katoh, A; Yoshida, T; Ohkanda, J;
Inhibition of farnesyltransferase increases TGF beta type II receptor expression and enhances the responsiveness of human cancer cells to TGF beta ONCOGENE,19(48):5525-5533 2000 Author:Adnane, J; Bizouarn, FA; Chen, Z; Ohkanda, J; Hamilton, AD; Munoz-Antonia, T; Sebti, SM;
Development of a tripeptide mimetic strategy for the inhibition of protein farnesyltransferase TETRAHEDRON,56(50):9833-9841 2000 Author:Kothare, MA; Ohkanda, J; Lockman, JW; Qian, YM; Blaskovich, MA; Sebti, SM; Hamilton, AD;
Synthesis of 6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline and application to a new fluorescence derivatization reagent of fatty acids for the high-performance liquid chromatographic analysis HETEROCYCLES,50(1):299-308 1999 Author:Katoh, A; Fujimoto, T; Takahashi, M; Ohkanda, J;
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I JOURNAL OF MEDICINAL CHEMISTRY,42(8):1333-1340 1999 Author:Vasudevan, A; Qian, YM; Vogt, A; Blaskovich, MA; Ohkanda, J; Sebti, SM; Hamilton, AD;
Novel nonthiol inhibitors of farnesyl transferase show potent antitumor properties. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,218:U984-U984 1999 Author:Ohkanda, J; Blaskovich, M; Sun, J; Sebti, SM; Hamilton, AD;
Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine CANCER RESEARCH,59(19):4919-4926 1999 Author:Sun, JZ; Blaskovich, MA; Knowles, D; Qian, YM; Ohkanda, J; Bailey, RD; Hamilton, AD; Sebti, SM;
N-hydroxyamide-containing heterocycles: Synthesis, reactivities, and iron(III)-chelating properties REVIEWS ON HETEROATOM CHEMISTRY,18:87-118 1998 Author:Ohkanda, J; Katoh, A;
N-hydroxypyrazinone-bearing homotrioxacalix[3]arene: its cooperative molecular recognition by metal complexation CHEMICAL COMMUNICATIONS,(3):375-376 1998 Author:Ohkanda, J; Shibui, H; Katoh, A;
Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,252(1):111-116 1998 Author:Kucich, U; Rosenbloom, JC; Shen, G; Abrams, WR; Blaskovich, MA; Hamilton, AD; Ohkanda, J; Sebti, SM; Rosenbloom, J;
New hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, alpha,omega-diamine and 1,1,1-tris(carboxyethoxymethyl)-ethane or tri(carboxybutyl)isocyanurate. Synthesis and characterization of their iron(III) complexes JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS,(22):3859-3864 1998 Author:Katoh, A; Hida, Y; Kamitani, J; Ohkanda, J;
Synthesis of 2,2 '-bipyridines bearing amino or carboxyl group at the side chain and physical properties of their ruthenium(II) complexes HETEROCYCLES,49:281-296 1998 Author:Katoh, A; Kitamura, Y; Fujii, H; Horie, Y; Satoh, T; Ohkanda, J; Yokomori, Y;
Functionalized N-hydroxyamide-containing heterocycles - Synthesis, reaction, and metal-chelating property JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN,55(6):524-534 1997(Jun.) Author:Ohkanda, J; Katoh, A;
Structural analysis of N-(omega-phenylalkyl)substituted quinoxalin-2(1H)-ones and -thiones HETEROCYCLES,44:357-366 1997 Author:Katoh, A; Yoshida, T; Ohkanda, J; Nishio, T;
Novel iron sequestering agents: Synthesis and iron-chelating properties of hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, omega-amino carboxylic acid, and tris(2-aminoethyl)amine JOURNAL OF ORGANIC CHEMISTRY,62(11):3618-3624 1997 Author:Ohkanda, J; Kamitani, J; Tokumitsu, T; Hida, Y; Konakahara, T; Katoh, A;
Synthesis of 1,3-linked 1,4-dihydropyridines containing the L-tyrosine residue and the influence of their structures upon the enantioselective reduction HETEROCYCLES,45(8):1441-1446 1997 Author:Katoh, A; Naruse, S; Ohkanda, J; Yamamoto, H;
N-hydroxyamide-containing heterocycles .6. Application of 1-hydroxy-4,6-dimethyl-2(1H)-pyrimidinone to a new benzyloxycarbonylating agent HETEROCYCLIC COMMUNICATIONS,2(2):141-144 1996 Author:Katoh, A; Kondoh, S; Ohkanda, J;
The influence of the chirality of synthetic iron chelators bearing N-hydroxy-2(1H)-pyrazinones and amino acid residues upon iron removal from human transferrin CHEMISTRY LETTERS,(6):423-424 1996 Author:Ohkanda, J; Katoh, A;
Synthesis of 2,3-disubstituted 6-aminoquinoxalines and their application to new fluorescence derivatization reagents for carboxylic acids CHEMISTRY LETTERS,(5):369-370 1996 Author:Katoh, A; Takahashi, M; Ohkanda, J;
Synthesis of novel amphiphilic compounds containing aza-12-crown-4 or D-glucosamine and their ion permeability HETEROCYCLES,43(3):589-599 1996 Author:Katoh, A; Ishida, S; Ohkanda, J; Washizu, M;
N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .4. SYNTHESIS AND FE-III-CHELATING PROPERTIES OF NOVEL HEXADENTATE LIGANDS COMPOSED OF N-HYDROXY-2(1H)-PYRAZINONE, AMINO-ACID-RESIDUES, AND TRIS(2-AMINOETHYL)AMINE JOURNAL OF ORGANIC CHEMISTRY,60(6):1583-1589 1995 Author:OHKANDA, J; KATOH, A;
N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .5. SYNTHESIS OF NOVEL HEXADENTATE LIGANDS COMPOSED OF N-HYDROXY-2(1H)-PYRAZINONE, ALIPHATIC DIAMINE, AND 1,1,1-TRIS(CARBOXYETHOXYMETHYL)ETHANE, AND PROPERTIES OF THEIR FERRIC COMPLEXES TETRAHEDRON,51(47):12995-13002 1995 Author:OHKANDA, J; KATOH, A;
SYNTHESIS OF 2(1H)-PYRIMIDINONE-CONTAINING ALPHA-AMINO-ACID DERIVATIVES BY CHEMICAL MODIFICATION OF L-GLUTAMIC ACID CHEMICAL & PHARMACEUTICAL BULLETIN,42(7):1514-1517 1994(Jul.) Author:KATOH, A; INOKAWA, M; OHKANDA, J; MITSUHASHI, K;
N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .3. THE RING TRANSFORMATION OF 1-BENZYLOXY-2(1H)-PYRIMIDINONES INTO 2-ISOXAZOLINES WITH HYDROXYLAMINE HETEROCYCLES,37(2):1141-1146 1994 Author:KATOH, A; OHKANDA, J; TAMURA, A; YOSHIIKE, Y; MITSUHASHI, K;
N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .2. SYNTHESIS AND IRON(III) COMPLEX-FORMING TENDENCY OF 1-HYDROXY-2(1H)-PYRIMIDINONE AND 1-HYDROXY-2(1H)-PYRAZINONE BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN,66(3):841-847 1993(Mar.) Author:OHKANDA, J; TOKUMITSU, T; MITSUHASHI, K; KATOH, A;
A CONVENIENT SYNTHESIS OF 3-(ARYL)SUBSTITUTED 2,4(1H,3H)-PTERIDINEDIONES AND THEIR ABSORPTION AND FLUORESCENCE SPECTROSCOPIC CHARACTERISTICS HETEROCYCLES,35(2):949-954 1993 Author:KATOH, A; OHKANDA, J; SATO, H; SAKAMOTO, T; MITSUHASHI, K;
N-HYDROXYAMIDE-CONTAINING HETEROCYCLES - NEW EFFECTIVE ADDITIVES FOR PEPTIDE-SYNTHESIS BY THE DICYCLOHEXYLCARBODIIMIDE METHOD CHEMISTRY LETTERS,(10):2009-2012 1992(Oct.) Author:KATOH, A; OHKANDA, J; ITOH, Y; MITSUHASHI, K;
STRUCTURAL ASPECTS OF THE MECHANICAL AND THERMAL-DISSOCIATION OF THE CENTRAL BOND IN 2,2'-BIS(2,3,4-TRIARYLCHROMENYL)S JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2,(1):59-63 1992(Jan.) Author:OHKANDA, J; MORI, Y; MAEDA, K; OSAWA, E;
UNUSUAL SUBSTITUENT EFFECT BY THE ALPHA-ACETYL GROUP ON THE TYPE-II PHOTOREACTION OF VALEROPHENONES - STRONG WAVELENGTH DEPENDENCE OF QUANTUM YIELDS JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,64(3):299-306 1992 Author:HASEGAWA, T; OHKANDA, J; KOBAYASHI, M; YOSHIOKA, M;
ISOLATION OF THE INTERMEDIATES AND IMPROVED SYNTHESIS OF PYRIDO[1',2'/1,2]IMIDAZOL[4,5-B]PYRAZINES AND PYRIDO[1',2'/1,2]IMIDAZOL]4,5-B]QUINOXALINES HETEROCYCLES,34(10):1965-1972 1992 Author:KATOH, A; UEDA, SH; OHKANDA, J; HIROTA, M; KOMINE, H; MITSUHASHI, K;