田中 沙智 (タナカ サチ)
学術研究院(農学系)
農学部 農学生命科学科 動物資源生命科学コース
准教授
研究者情報
研究キーワード
- 食品免疫
メールアドレス
- tanakasa★shinshu-u.ac.jp
ホームページURL
経歴
研究活動情報
受賞
論文
- Mechanisms of interleukin-10 induction in murine spleen and RAW264 cells by Latilactobacillus curvatus K4G4 isolated from fermented Brassica rapa L.
Okano A, Tanaka S, Yamada K, Hashimoto N, Watanabe J.
Biosci Microbiota Food Health., 43(3), 227-233, 2024年05月 - Heat-killed Lactiplantibacillus plantarum Shinshu N-07 exerts antiobesity effects in western diet-induced obese mice.
Tanaka Y, Inaba C, Sawa T, Endo K, Saiki T, Haga H, Niitsuma F, Kawahara T, Watanabe J, Tanaka S.
J Appl Microbiol., 135(5), lxae119, 2024年05月 - Characterization and anti-tumor activities of polysaccharide isolated from Brassica rapa L. via activation of macrophages through TLR2-and TLR4-Dependent pathways.
Matsui R, Endo K, Saiki T, Haga H, Shen W, Wang X, Yamazaki S, Katayama S, Nagata K, Kitamura H, Tanaka S.
Arch Biochem Biophys., 752, 109879, 2024年02月 - Oral administration of procyanidin B2 3,3"-di-O-gallate ameliorates experimental autoimmune encephalomyelitis through immunosuppressive effects on CD4+ T cells by regulating glycolysis.
Endo K, Sawa T, Tanaka Y, Saiki T, Haga H, Rizeq L, Aso H, Isono M, Niitsuma F, Masaki A, Makabe H, Tanaka S.
European Journal of Pharmacology, 954, 175879, 2023年07月 - Brassica rapa L. prevents Western diet-induced obesity in C57BL/6 mice through its binding capacity of cholesterol and fat.
Tanaka Y, Inaba C, Sawa T, Endo K, Saiki T, Haga H, Tanaka S.
Biomed Pharmacother., 86, 2023年06月 - Procyanidin B2 3,3''-di-O-gallate ameliorates imiquimod-induced skin inflammation by suppressing TLR7 signaling through the inhibition of endosomal acidification in dendritic cells.
Sawa T, Endo K, Nakashima A, Tanaka Y, Makabe H, Tanaka S
International Immunopharmacology., 121, 110444, 2023年06月 - Modulation of immune function and changes in intestinal flora by Brassica rapa L. (Nozawana).
Sashi Tanaka
Biosci Biotechnol Biochem., 87(5), 465-472, 2023年04月 - Procyanidin B2 3,3″-di-O-gallate suppresses IFN-γ production in murine CD4+ T cells through the regulation of glutamine influx via direct interaction with ASCT2.
Endo K, Sawa T, Kitamura H, Umezawa K, Makabe H, Tanaka S.
International Immunopharmacology., 115, 109617, 2022年12月 - Long-term caloric restriction ameliorates T cell immunosenescence in mice.
Asami T, Endo K, Matsui R, Sawa T, Tanaka Y, Saiki T, Tanba N, Haga H, Tanaka S.
Mech Ageing Dev., 206, 111710, 2022年07月20日 - Metabolomic evaluation of different starter culture effects on water-soluble and volatile compound profiles in nozawana pickle fermentation.
Tomita S, Watanabe J, Kuribayashi T, Tanaka S, Kawahara T.
Food Chemistry: Molecular Sciences., 2, 100019, 2022年07月 - Dietary Supplementation with Fermented Brassica rapa L. Stimulates Defecation Accompanying Change in Colonic Bacterial Community Structure.
Tanaka S, Yamamoto K, Hamajima C, Takahashi F, Endo K, Uyeno Y.
Nutrients, 13(6), 1847, 2021年05月 - Brassica rapa L. activates macrophages via Toll-like receptors.
Takahashi F, Endo K, Matsui R, Yamamoto K, Tanaka S.
Biosci Biotechnol Biochem., 85(3), 656-665, 2021年02月24日 - The suppression of IL-17 production from T cells by gallate-type procyanidin is mediated by selectively inhibiting cytokine production from dendritic cells.
Endo K, Matsui R, Asami T, Sawa T, Nakashima A, Tanaka Y, Makabe H, Tanaka S.
Biomed Pharmacother., 137, 111346, 2021年02月05日 - MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages.
Yamada K, Takizawa S, Ohgaku Y, Asami T, Furuya K, Yamamoto K, Takahashi F, Hamajima C, Inaba C, Endo K, Matsui R, Kitamura H, Tanaka S.
GENE, 725, 144191, 2020年01月 - Transcriptome analysis of the effect of C-C chemokine receptor 5 deficiency on cell response to Toxoplasma gondii in brain cells.
Kobayashi K, Umeda K, Ihara F, Tanaka S, Yamagishi J, Suzuki Y, Nishikawa Y.
BMC Genomics., 20, 705, 2019年09月 - Involvement of Toll-like receptor 2 in the cerebral immune response and behavioral changes caused by latent Toxoplasma infection in mice.
Ihara F, Tanaka S, Fereig RM, Nishimura M, Nishikawa Y.
PLoS One., 14, e0220560, 2019年08月 - Characterization of Microbiota that Influence Immunomodulatory Effects of Fermented Brassica rapa L.
Bayanjargal Sandagdorj, Chisato Hamajima, Takeshi Kawahara, Jun Watanabe, Sachi Tanaka
Microbes and Environments, 34, 206-214, 2019年06月 - Enhanced Anti-Allergic Activity of Milk Casein Phosphopeptide by Additional Phosphorylation in Ovalbumin-Sensitized Mice.
Lebetwa N, Suzuki Y, Tanaka S, Nakamura S, Katayama S.
MOLECULES, 24, E738, 2019年02月 - Soybean-Derived Glycine-Arginine Dipeptide Administration Promotes Neurotrophic Factor Expression in the Mouse Brain.
Shimizu A, Mitani T, Tanaka S, Fujii H, Maebuchi M, Amiya Y, Tanaka M, Matsui T, Nakamura S, Katayama S.
J Agric Food Chem., 66(30), 7935-7941, 2018年08月01日 - Enhancement of natural killer activity and IFN-γ production in an IL-12-dependent manner by a Brassica rapa L.
Yamamoto K, Furuya K, Yamada K, Takahashi F, Hamajima C, and Tanaka S.
Bioscience, Biotechnology, and Biochemistry., 82, 654-668, 2018年04月 - Transcriptional profiling 1 of Toll-like receptor 2-deficient primary murine brain cells during Toxoplasma gondii infection.
Umeda K, Tanaka S, Ihara F, Yamagishi J, Suzuki Y, and Nishikawa Y.
PLoS One., 12, e0187703, 2017年11月06日 - Changes in Gut Microbial Ecology and Immunological Responses of Mice Fed the Insoluble Fraction of Brassica rapa L. that was Fermented or Not.
Tanaka S, Furuya K, Yamamoto K, Yamada K, Ichikawa M, Suda M, Makabe H.
Microbes and Environments, 32, 268-274, 2017年09月 - Procyanidin B2 gallates inhibit IFN-γ and IL-17 production in T cells by suppressing T-bet and RORγt expression.
Tanaka S, Furuya K, Yamamoto K, Yamada K, Ichikawa M, Suda M, Makabe H.
International Immunopharmacology., 44, 87-96, 2017年03月 - Relationship of enhanced butyrate production by colonic butyrate-producing bacteria and immunomodulatory effects in normal mice fed insoluble fraction of Brassica rapa L..
Tanaka S, Yamamoto K, Yamada K, Furuya K, Uyeno Y.
Applied and Environmental Microbiology., 82, 2693-2699, 2016年04月 - Transcriptome and Histopathological Changes in Mouse Brain Infected with Neospora caninum.
Nishimura M, Tanaka S, Ihara F, Muroi Y, Yamagishi J, Furuoka H, Suzuki Y, Nishikawa Y.
Scientific Reports., 5, 7936, 2015年01月 - Antioxidant and cytoprotective activities of extracts prepared from fruit and vegetable wastes and by-products.
Kabir F, Tow WW, Hamauzu Y, Katayama S, Tanaka S, Nakamura S,
Food Chemistry, 15, 358-362, 2015年01月 - Role of the chemokine receptor CCR5-dependent host defense system in Neospora caninum infections.
Abe C, Tanaka S, Nishimura M, Ihara F, Xuan X, Nishikawa Y.
Parasites & Vectors., 8, 5, 2015年01月 - Inhibitory/suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice.
Wang Y, Yamamoto Y, Shigemori S, Watanabe T, Oshiro K, Wang X, Wang P, Sato T, Yonekura S, Tanaka S, Kitazawa H, Shimosato T.
Molecular Therapy., 23(2), 297-309, 2015年 - Plasmodium berghei circumsporozoite protein encapsulated in oligomannose-coated liposomes confers protection against sporozoite infection in mice.
Terkawi MA, Kuroda Y, Fukumoto S, Tanaka S, Kojima N, Nishikawa Y.
Malaria Journal., 13, 426, 2014年11月 - Macrophage depletion prior to Neospora caninum infection results in severe neosporosis in mice.
Abe C, Tanaka S, Ihara F, Nishikawa Y,
Clinical and Vaccine Immunology, 21, 1185-1188, 2014年08月 - Vaccination with profilin encapsulated in oligomannose-coated liposomes induces significant protective immunity against Toxoplasma gondii
Tanaka S, Kuroda Y, Ihara F, Nishimura M, Hiasa J, Kojima N, Nishikawa Y.
Vaccine, 32, 1781-1785, 2014年04月 - Overproduction of Toxoplasma gondii cyclophilin-18 regulates host cell migration and enhances parasite dissemination in a CCR5-independent manner
Ibrahim HM, Nishimura M, Tanaka S, Awadin W, Furuoka H, Xuan X, Nishikawa Y.
BMC Microbiology, 14, 76, 2014年03月 - Transcriptome Analysis of Mouse Brain Infected with Toxoplasma gondii
Tanaka S, Nishimura M, Ihara F, Yamagishi J, Suzuki Y, Nishikawa Y
Infection and Immunity, 81(10), 3609-3619, 2013年10月 - Oligomannose-coated liposome-entrapped dense granule protein 7 induces protective immune response to Neospora caninum in cattle
Nishimura M, Kohara J, Kuroda Y, Hiasa J, Tanaka S, Muroi Y, Kojima N, Furuoka H, Nishikawa Y
Vaccine, 31(35), 3528-3535, 2013年08月 - Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner
Koizumi SI, Masuko K, Wakita D, Tanaka S, Mitamura R, Kato Y, Tabata H, Nakahara M, Kitamura H, Nishimura T
CELLULAR IMMUNOLOGY, 276, 153-161, 2012年04月 - Toll-like receptor-dependent IL-12 production by dendritic cells is required for activation of natural killer cell-mediated Type-1 immunity induced by Chrysanthemum coronarium L.
Tanaka S, Koizumi S, Masuko K, Makiuchi N, Aoyagi Y, Quivy E, Mitamura R, Kano T, Ohkuri T, Wakita D, Chamoto K, Kitamura H, Nishimura T
International Immunopharmacology, 11, 226-232, 2011年 - The extract of Japanese soybean, Kurosengoku activates the production of IL-12 and IFN-γ by DC or NK1.1(+) cells in a TLR4- and TLR2-dependent manner
Tanaka S, Koizumi S, Makiuchi N, Aoyagi Y, Quivy E, Mitamura R, Kano T, Wakita D, Chamoto K, Kitamura H, Nishimura T
CELLULAR IMMUNOLOGY, 266, 135-142, 2011年 - Intrauterine administration of peripheral blood mononuclear cells enhances early development of the pre-implantation bovine embryo
Ideta A, Hayama K, Nakamura Y, Sakurai T, Tsuchiya K, Tanaka S, Yamaguchi T, Fujiwara H, Imakawa K, Aoyagi Y
Molecular Reproduction and Development, 77, 954-962, 2010年 - Transcytosis of murine-adapted bovine spongiform encephalopathy agents in an in vitro bovine M cell model
Miyazawa K, Kanaya T, Takakura I, Tanaka S, Hondo T, Watanabe H, Rose MT, Kitazawa H, Yamaguchi T, Katamine S, Nishida N, Aso H
Journal of Virology, 84, 12285-12291, 2010年 - Characterization of newly established bovine intestinal epithelial cell line
Miyazawa K, Hondo T, Kanaya T, Tanaka S, Takakura I, Itani W, Rose MT, Kitazawa H, Yamaguchi T, Aso H
HISTOCHEMISTRY AND CELL BIOLOGY, 133, 125-134, 2010年 - Differential responses between monocytes and monocyte-derived macrophages for lipopolysaccharide stimulation of calves
Guo Y, Zhao G, Tanaka S, Yamaguchi T
Cellular&Molecular Immunology, 6, 223-229, 2009年 - Expression of hyaluronan synthase 1 and distribution of hyaluronan during follicular atresia in pig ovaries
Miyake Y, Sakurai M, Tanaka S, Tunjung WA, Yokoo M, Matsumoto H, Aso H, Yamaguchi T, Sato E
BIOLOGY OF REPRODUCTION, 80, 249-257, 2009年 - Anterior pituitary progenitor cells express costimulatory molecule 4Ig-B7-H3
Nagai Y, Aso H, Ogasawara H, Tanaka S, Taketa Y, Watanabe K, Ohwada S, Rose MT, Kitazawa H, Yamaguchi T
JOURNAL OF IMMUNOLOGY, 181, 6073-6081, 2008年 - Presence of neuropeptide Y in somatotrophs of cattle
Ogasawara H, Aso H, Nagai Y, Matsumoto K, Okumura H, Tanaka S, Watanabe K, Ohwada S, Yamaguchi T
DOMESTIC ANIMAL ENDOCRINOLOGY, 35, 274-280, 2008年 - Differential cytokine expression in T cell subsets from bovine peripheral blood
Tanaka S, Nagai Y, Noguchi Y, Miyake M, Watanabe K, Ohwada S, Aso H, Yamaguchi T
ANIMAL SCIENCE JOURNAL, 79, 597-604, 2008年 - Localization of leptin and leptin receptor in the bovine adenohypophysis
Ogasawara H, Ohwada S, Nagai Y, Taketa Y, Matsuzaki M, Tanaka S, Watanabe K, Aso H, Yamaguchi T
DOMESTIC ANIMAL ENDOCRINOLOGY, 35, 8-15, 2008年 - Differential expression of myostatin and its receptor in the porcine anterior pituitary gland
Taketa Y, Nagai Y, Ogasawara H, Hayashi S, Miyake M, Tanaka S, Watanabe K, Ohwada S, Aso H, Yamaguchi T
ANIMAL SCIENCE JOURNAL, 79, 382-390, 2008年 - Age-related changes in leukocytes and T cell subsets in peripheral blood of Japanese Black cattle
Tanaka S, Miyazawa K, Kuwano A, Watanabe K, Ohwada S, Aso H, Nishida S, Yamaguchi T
ANIMAL SCIENCE JOURNAL, 79, 368-374, 2008年 - Myostatin and MyoD family expression in skeletal muscle of IGF-1 knockout mice
Miyake M, Hayashi S, Sato T, Taketa Y, Watanabe K, Hayashi S, Tanaka S, Ohwada S, Aso H, Yamaguchi T
CELL BIOLOGY INTERNATIONAL, 3, 1274-1279, 2007年 - Differential cytokine gene expression in CD4+ and CD8+ T cell subsets of calves
Tanaka S, Aso H, Miyazawa K, Nagai Y, Watanabe K, Ohwada S, Kobayashi J, Yamaguchi T
Veterinary Immunology and Immunopathology, 118, 84-91, 2007年 - 黒毛和種体細胞クローン牛の末梢血におけるT細胞サブセットの解析
田中沙智、宮澤光太郎、永井康裕、桑野敦子、渡邊康一、大和田修一、麻生久、西田茂、児玉英樹、吉川恵郷、笠井幸治、山口高弘
東北畜産学会報, 57, 13-18, 2007年 - Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and mice
Miyazawa K, Kanaya T, Tanaka S, Takakura I, Watanabe K, Ohwada S, Kitazawa H, Rose MT, Sakaguchi S, Katamine S, Yamaguchi T, Aso H
HISTOCHEMISTRY AND CELL BIOLOGY, 127, 291-301, 2007年 - Comparison of T cell subsets between somatic cloned and normal cow
Tanaka S, Miyazawa K, Watanabe K, Ohwada S, Aso H, Yonai M, Saito N, Yamaguchi T
American Journal of Reproductive Immunology, 55, 28-35, 2006年
書籍等出版物
講演・口頭発表等
- Extract of Japanese soybean, Kurosengoku (Glycine max), activates Type-1 immunity via IL-12 production in a Toll-like receptor 2- and 4-dependent manner
Tanaka S, Koizumi S, Makiuchi N, Aoyagi Y, Masuko K, Quivy E, Mitamura R, Wakita D, Kitamura H and Nishimura T
14th International Congress of Immunology, 2010年
共同研究・競争的資金等の研究課題
- プロシアニジンガレートによるTLR7制御メカニズムの解明と皮膚炎予防効果の検証
科学研究費補助金, 基盤研究(C)
2022年 - 2024年 - 免疫-代謝制御を介したプロシアニジン化合物の慢性炎症に対する抑制効果の解明
科学研究費補助金, 基盤研究(C)
2019年04月01日 - 2022年03月31日 - 食事制限による炎症性腸疾患の予防・改善メカニズムの解明と応用に向けた研究
科学研究費補助金, 若手研究(B)
2016年04月01日 - 2018年03月31日 - カロリー制限食の摂取に伴うマイクロRNAを介した免疫増強メカニズムの解明
科学研究費補助金, 若手研究(B)
2014年04月01日 - 2016年03月31日 - トキソプラズマ感染における中枢神経系障害の発症メカニズムの解明
科学研究費補助金, 研究活動スタート支援
2012年08月31日 - 2014年03月31日 - 食品由来成分の免疫機能制御因子の探索とその応用に関する研究