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田中沙智  タナカ サチ

教員組織学術研究院(農学系)電話番号
教育組織農学部 農学生命科学科 動物資源生命科学コースFAX番号
職名准教授メールアドレス
住所〒399-4598 長野県上伊那郡南箕輪村8304ホームページURL

プロフィール

研究分野
免疫学
現在の研究課題
食品由来免疫バランス制御因子の探索とその応用に関する研究
キーワード:免疫バランス , インターフェロン , T細胞
所属学会
所属学会
日本食品免疫学会
日本農芸化学会
学歴
出身大学院
2009 , 東北大学大学院 , 農学研究科 , 応用生命科学専攻
2006 , 東北大学大学院 , 農学研究科 , 応用生命科学専攻

出身学校・専攻等(大学院を除く)
2004 , 東北大学 , 農学部 , 生物生産科学科

取得学位
博士(農学) , 東北大学大学院農学研究科
受賞学術賞
2017 , 農芸化学若手女性研究者賞
2015 , 日本食品免疫学会ポスター賞
2009 , 日本畜産学会奨励賞
2008 , 東北畜産学会奨励賞
2006 , 東北大学大学院農学研究科長賞
研究職歴等
研究職歴
2018- , 信州大学農学部 准教授
2013-2018 , 信州大学農学部 助教(テニュアトラック)
2012-2013 , 帯広畜産大学原虫病研究センター 特任研究員
2009-2012 , 北海道大学遺伝子病制御研究所 日本学術振興会特別研究員

研究活動業績

研究業績(著書・
発表論文等)
著書
牛の免疫の基礎
乳房炎防除・乳質向上・免疫力アップ , Dairy Japan 2012年2月臨時増刊号:2-9 2012(Feb.)
Author:田中沙智


論文
MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages.
Gene,725:144191 2020(Jan.)
Author:Yamada K, Takizawa S, Ohgaku Y, Asami T, Furuya K, Yamamoto K, Takahashi F, Hamajima C, Inaba C, Endo K, Matsui R, Kitamura H, Tanaka S.


Transcriptome analysis of the effect of C-C chemokine receptor 5 deficiency on cell response to Toxoplasma gondii in brain cells.
BMC Genomics.,20:705 2019(Sep.)
Author:Kobayashi K, Umeda K, Ihara F, Tanaka S, Yamagishi J, Suzuki Y, Nishikawa Y.


Involvement of Toll-like receptor 2 in the cerebral immune response and behavioral changes caused by latent Toxoplasma infection in mice.
PLoS One.,14:e0220560 2019(Aug.)
Author:Ihara F, Tanaka S, Fereig RM, Nishimura M, Nishikawa Y.


Characterization of Microbiota that Influence Immunomodulatory Effects of Fermented Brassica rapa L.
Microbes and Environments,34:206-214 2019(Jun.)
Author:Bayanjargal Sandagdorj, Chisato Hamajima, Takeshi Kawahara, Jun Watanabe, Sachi Tanaka


Enhanced Anti-Allergic Activity of Milk Casein Phosphopeptide by Additional Phosphorylation in Ovalbumin-Sensitized Mice.
Molecules,24:E738 2019(Feb.)
Author:Lebetwa N, Suzuki Y, Tanaka S, Nakamura S, Katayama S.


Soybean-Derived Glycine-Arginine Dipeptide Administration Promotes Neurotrophic Factor Expression in the Mouse Brain.
J Agric Food Chem.,66(30):7935-7941 2018(Aug. 01)
Author:Shimizu A, Mitani T, Tanaka S, Fujii H, Maebuchi M, Amiya Y, Tanaka M, Matsui T, Nakamura S, Katayama S.


Enhancement of natural killer activity and IFN-γ production in an IL-12-dependent manner by a Brassica rapa L.
Bioscience, Biotechnology, and Biochemistry.,82:654-668 2018(Apr.)
Author:Yamamoto K, Furuya K, Yamada K, Takahashi F, Hamajima C, and Tanaka S.


Transcriptional profiling 1 of Toll-like receptor 2-deficient primary murine brain cells during Toxoplasma gondii infection.
PLoS One.,12:e0187703 2017(Nov. 06)
Author:Umeda K, Tanaka S, Ihara F, Yamagishi J, Suzuki Y, and Nishikawa Y.


Changes in Gut Microbial Ecology and Immunological Responses of Mice Fed the Insoluble Fraction of Brassica rapa L. that was Fermented or Not.
Microbes and Environments,32:268-274 2017(Sep.)
Author:Tanaka S, Furuya K, Yamamoto K, Yamada K, Ichikawa M, Suda M, Makabe H.


Procyanidin B2 gallates inhibit IFN-γ and IL-17 production in T cells by suppressing T-bet and RORγt expression.
International Immunopharmacology. ,44:87-96 2017(Mar.)
Author:Tanaka S, Furuya K, Yamamoto K, Yamada K, Ichikawa M, Suda M, Makabe H.


Relationship of enhanced butyrate production by colonic butyrate-producing bacteria and immunomodulatory effects in normal mice fed insoluble fraction of Brassica rapa L..
Applied and Environmental Microbiology. ,82:2693-2699 2016(Apr.)
Author:Tanaka S, Yamamoto K, Yamada K, Furuya K, Uyeno Y.


食品成分による免疫制御メカニズム.
信州大学農学部紀要.,51:1-8 2015(Mar.)
Author:田中沙智


Role of the chemokine receptor CCR5-dependent host defense system in Neospora caninum infections.
Parasites & Vectors. ,8:5 2015(Jan.)
Author:Abe C, Tanaka S, Nishimura M, Ihara F, Xuan X, Nishikawa Y.


Antioxidant and cytoprotective activities of extracts prepared from fruit and vegetable wastes and by-products.
Food Chemistry,15:358-362 2015(Jan.)
Author:Kabir F, Tow WW, Hamauzu Y, Katayama S, Tanaka S, Nakamura S,


Transcriptome and Histopathological Changes in Mouse Brain Infected with Neospora caninum.
Scientific Reports. ,5:7936 2015(Jan.)
Author:Nishimura M, Tanaka S, Ihara F, Muroi Y, Yamagishi J, Furuoka H, Suzuki Y, Nishikawa Y.


Inhibitory/suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice.
Molecular Therapy.,23(2):297-309 2015
Author:Wang Y, Yamamoto Y, Shigemori S, Watanabe T, Oshiro K, Wang X, Wang P, Sato T, Yonekura S, Tanaka S, Kitazawa H, Shimosato T.


Plasmodium berghei circumsporozoite protein encapsulated in oligomannose-coated liposomes confers protection against sporozoite infection in mice.
Malaria Journal.,13:426 2014(Nov.)
Author:Terkawi MA, Kuroda Y, Fukumoto S, Tanaka S, Kojima N, Nishikawa Y.


Macrophage depletion prior to Neospora caninum infection results in severe neosporosis in mice.
Clinical and Vaccine Immunology,21:1185-1188 2014(Aug.)
Author:Abe C, Tanaka S, Ihara F, Nishikawa Y,


Vaccination with profilin encapsulated in oligomannose-coated liposomes induces significant protective immunity against Toxoplasma gondii
Vaccine,32:1781-1785 2014(Apr.)
Author:Tanaka S, Kuroda Y, Ihara F, Nishimura M, Hiasa J, Kojima N, Nishikawa Y.


Overproduction of Toxoplasma gondii cyclophilin-18 regulates host cell migration and enhances parasite dissemination in a CCR5-independent manner
BMC Microbiology,14:76 2014(Mar.)
Author:Ibrahim HM, Nishimura M, Tanaka S, Awadin W, Furuoka H, Xuan X, Nishikawa Y.


Transcriptome Analysis of Mouse Brain Infected with Toxoplasma gondii
Infection and Immunity,81(10):3609-3619 2013(Oct.)
Author:Tanaka S, Nishimura M, Ihara F, Yamagishi J, Suzuki Y, Nishikawa Y


Oligomannose-coated liposome-entrapped dense granule protein 7 induces protective immune response to Neospora caninum in cattle
Vaccine,31(35):3528-3535 2013(Aug.)
Author:Nishimura M, Kohara J, Kuroda Y, Hiasa J, Tanaka S, Muroi Y, Kojima N, Furuoka H, Nishikawa Y


Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner
Cellular Immunology,276:153-161 2012(Apr.)
Author:Koizumi SI, Masuko K, Wakita D, Tanaka S, Mitamura R, Kato Y, Tabata H, Nakahara M, Kitamura H, Nishimura T


The extract of Japanese soybean, Kurosengoku activates the production of IL-12 and IFN-γ by DC or NK1.1(+) cells in a TLR4- and TLR2-dependent manner
Cellular Immunology,266:135-142 2011
Author:Tanaka S, Koizumi S, Makiuchi N, Aoyagi Y, Quivy E, Mitamura R, Kano T, Wakita D, Chamoto K, Kitamura H, Nishimura T


Toll-like receptor-dependent IL-12 production by dendritic cells is required for activation of natural killer cell-mediated Type-1 immunity induced by Chrysanthemum coronarium L.
International Immunopharmacology,11:226-232 2011
Author:Tanaka S, Koizumi S, Masuko K, Makiuchi N, Aoyagi Y, Quivy E, Mitamura R, Kano T, Ohkuri T, Wakita D, Chamoto K, Kitamura H, Nishimura T


Characterization of newly established bovine intestinal epithelial cell line
Histochemistry and Cell Biology,133:125-134 2010
Author:Miyazawa K, Hondo T, Kanaya T, Tanaka S, Takakura I, Itani W, Rose MT, Kitazawa H, Yamaguchi T, Aso H


Transcytosis of murine-adapted bovine spongiform encephalopathy agents in an in vitro bovine M cell model
Journal of Virology,84:12285-12291 2010
Author:Miyazawa K, Kanaya T, Takakura I, Tanaka S, Hondo T, Watanabe H, Rose MT, Kitazawa H, Yamaguchi T, Katamine S, Nishida N, Aso H


Intrauterine administration of peripheral blood mononuclear cells enhances early development of the pre-implantation bovine embryo
Molecular Reproduction and Development,77:954-962 2010
Author:Ideta A, Hayama K, Nakamura Y, Sakurai T, Tsuchiya K, Tanaka S, Yamaguchi T, Fujiwara H, Imakawa K, Aoyagi Y


Expression of hyaluronan synthase 1 and distribution of hyaluronan during follicular atresia in pig ovaries
Biology of Reproduction,80:249-257 2009
Author:Miyake Y, Sakurai M, Tanaka S, Tunjung WA, Yokoo M, Matsumoto H, Aso H, Yamaguchi T, Sato E


Differential responses between monocytes and monocyte-derived macrophages for lipopolysaccharide stimulation of calves
Cellular&Molecular Immunology,6:223-229 2009
Author:Guo Y, Zhao G, Tanaka S, Yamaguchi T


Age-related changes in leukocytes and T cell subsets in peripheral blood of Japanese Black cattle
Animal Science Journal,79:368-374 2008
Author:Tanaka S, Miyazawa K, Kuwano A, Watanabe K, Ohwada S, Aso H, Nishida S, Yamaguchi T


Differential expression of myostatin and its receptor in the porcine anterior pituitary gland
Animal Science Journal,79:382-390 2008
Author:Taketa Y, Nagai Y, Ogasawara H, Hayashi S, Miyake M, Tanaka S, Watanabe K, Ohwada S, Aso H, Yamaguchi T


Localization of leptin and leptin receptor in the bovine adenohypophysis
Domestic Animal Endocrinology,35:8-15 2008
Author:Ogasawara H, Ohwada S, Nagai Y, Taketa Y, Matsuzaki M, Tanaka S, Watanabe K, Aso H, Yamaguchi T


Differential cytokine expression in T cell subsets from bovine peripheral blood
Animal Science Journal,79:597-604 2008
Author:Tanaka S, Nagai Y, Noguchi Y, Miyake M, Watanabe K, Ohwada S, Aso H, Yamaguchi T


Presence of neuropeptide Y in somatotrophs of cattle
Domestic Animal Endocrinology,35:274-280 2008
Author:Ogasawara H, Aso H, Nagai Y, Matsumoto K, Okumura H, Tanaka S, Watanabe K, Ohwada S, Yamaguchi T


Anterior pituitary progenitor cells express costimulatory molecule 4Ig-B7-H3
Journal of Immunology,181:6073-6081 2008
Author:Nagai Y, Aso H, Ogasawara H, Tanaka S, Taketa Y, Watanabe K, Ohwada S, Rose MT, Kitazawa H, Yamaguchi T


Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and mice
Histochemistry and Cell Biology,127:291-301 2007
Author:Miyazawa K, Kanaya T, Tanaka S, Takakura I, Watanabe K, Ohwada S, Kitazawa H, Rose MT, Sakaguchi S, Katamine S, Yamaguchi T, Aso H


黒毛和種体細胞クローン牛の末梢血におけるT細胞サブセットの解析
東北畜産学会報,57:13-18 2007
Author:田中沙智、宮澤光太郎、永井康裕、桑野敦子、渡邊康一、大和田修一、麻生久、西田茂、児玉英樹、吉川恵郷、笠井幸治、山口高弘


Differential cytokine gene expression in CD4+ and CD8+ T cell subsets of calves
Veterinary Immunology and Immunopathology,118:84-91 2007
Author:Tanaka S, Aso H, Miyazawa K, Nagai Y, Watanabe K, Ohwada S, Kobayashi J, Yamaguchi T


Myostatin and MyoD family expression in skeletal muscle of IGF-1 knockout mice
Cell Biology International,3:1274-1279 2007
Author:Miyake M, Hayashi S, Sato T, Taketa Y, Watanabe K, Hayashi S, Tanaka S, Ohwada S, Aso H, Yamaguchi T


Comparison of T cell subsets between somatic cloned and normal cow
American Journal of Reproductive Immunology,55:28-35 2006
Author:Tanaka S, Miyazawa K, Watanabe K, Ohwada S, Aso H, Yonai M, Saito N, Yamaguchi T


学会発表
Extract of Japanese soybean, Kurosengoku (Glycine max), activates Type-1 immunity via IL-12 production in a Toll-like receptor 2- and 4-dependent manner
14th International Congress of Immunology , (Aug. 22-27) 2010
Author:Tanaka S, Koizumi S, Makiuchi N, Aoyagi Y, Masuko K, Quivy E, Mitamura R, Wakita D, Kitamura H and Nishimura T


Bovine γδ T cells display cytotoxic activity following IL-2 stimulation
The 4th Congress of the Federation of Immunology Societies of Asia-Oceania (FIMSA 2008) , (Oct. 17-20) 2008
Author:Tanaka S, Noguchi Y, Guo Y, Abe H, Suzuki R, Watanabe K, Ohwada S, Aso H, Yamaguchi T


Comparative expression of activin receptor type IIB in bovine peripheral blood mononuclear cells
2007 ADSA-PSA-AMPA-ASAS Joint Annual Meeting (American Society of Animal Science, American Dairy Science Association, and Canadian Society of Animal Science) , (Jul. 8-12) 2007
Author:Tanaka S, Hayashi S, Taketa Y, Miyake M, Watanabe K, Ohwada S, Aso H, Yamaguchi T


Age-related changes of leukocytes and T cell subsets in peripheral blood of Japanese Black cattle
12th AAAP Animal Science Congress , (Sep. 18-22) 2006
Author:Tanaka S, Miyazawa K, Watanabe K, Ohwada S, Aso H, Nishida S, Yamaguchi T


Cytokine expression of T cell subsets in bovine peripheral blood
2005 ADSA-ASAS-CSAS Joint Annual Meeting (American Society of Animal Science, American Dairy Science Association, and Canadian Society of Animal Science) , (Jul. 24-28) 2005
Author:Tanaka S, Miyazawa K, Watanabe K, Ohwada S, Aso H, Yamaguchi T

研究費
科学研究費補助金(研究代表者)
2016 - 2017 , 食事制限による炎症性腸疾患の予防・改善メカニズムの解明と応用に向けた研究 , 若手研究(B)
2014 - 2015 , カロリー制限食の摂取に伴うマイクロRNAを介した免疫増強メカニズムの解明 , 若手研究(B)
2012 - 2013 , トキソプラズマ感染における中枢神経系障害の発症メカニズムの解明 , 研究活動スタート支援